}
}
@inproceedings{ISMRM2018_3529,
annote={ISMRM2018_3529},
pages={3529},
file={ISMRM2018_3529.pdf:ISMRM2018_3529.pdf:PDF},
title={Joint Reconstruction of Images with Different Temporal Basis in Carotid Vessel Wall Imaging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3529.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Nan Wang and Anthony Christodoulou and Yibin Xie and Zixin Deng and Zhaoyang Fan and Debiao Li},
abstract={We recently proposed two techniques, qMATCH and DCE, based on Low Rank Tensor (LRT) framework. qMATCH is a single 8-min scan for carotid T1 T2 mapping and LRT DCE is a 10-min scan evaluating inflammatory status of carotid atherosclerosis. The LRT DCE has many advantages over conventional DCE protocols, but has a scan time longer than typical 5-6 minutes. In this work, we proposed a new protocol combining qMATCH and 5-min DCE. In vivo studies have demonstrated the feasibility of the joint reconstruction. Results of joint reconstruction showed improved image quality with shortened scan time.}
}
@inproceedings{ISMRM2018_3530,
annote={ISMRM2018_3530},
pages={3530},
file={ISMRM2018_3530.pdf:ISMRM2018_3530.pdf:PDF},
title={Accelerated Localized Correlated Spectroscopy with Compressed Sensing Reconstruction Using Joint Hankel Low Rank Regularization and Group Sparsity},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3530.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Andres Saucedo and Manoj K. Sarma and M. Albert Thomas},
abstract={Compressed sensing (CS) combined with non-uniform undersampling, such as the low-rank Hankel matrix completion method, have accelerated the acquisition time of 2D magnetic resonance spectroscopy (MRS). This technique relies on reconstructing the vector of all t
point. We introduce a CS-based method that implements joint Hankel low rank regularization, which enforces the low-rankness of all Hankel matrices formed from the entire F
data simultaneously. We compare this method with group sparsity CS reconstruction of retrospectively undersampled localized correlated spectroscopy (COSY) acquisitions in a brain phantom and calf muscle.}
}
@inproceedings{ISMRM2018_3531,
annote={ISMRM2018_3531},
pages={3531},
file={ISMRM2018_3531.pdf:ISMRM2018_3531.pdf:PDF},
title={Patch-Tensor Low-n-Rank Reconstruction for Oscillating Steady State f{MRI} Acceleration},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3531.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Shouchang Guo and Douglas C. Noll},
abstract={Oscillating steady-state imaging is a new acquisition method for T2*-weighted functional MRI that offers very high SNR, but longer acquisition times. The oscillations are highly reproducible, which make low-rank models suitable. In this work, a sparse sampling scheme combined with a patch-based low-rank tensor reconstruction is introduced to speed the image acquisitions. The low-n-rank algorithm was applied to oscillating steady state data to demonstrate the utility of this approach for functional MRI, demonstrating a 17-fold speed up with error levels less than 3\%.}
}
@inproceedings{ISMRM2018_3532,
annote={ISMRM2018_3532},
pages={3532},
file={ISMRM2018_3532.pdf:ISMRM2018_3532.pdf:PDF},
title={Gini reweighted ℓ1 minimization for rapid {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3532.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Carlos Castillo-Passi and Claudia Prieto and Gabriel Varela-Mattatall and Carlos Sing-Long and Pablo Irarrazaval},
abstract={Under-sampling acquisition is oftenly used to reduce the scan time. Compressed Sensing allows the reconstruction of these data by solving a convex optimization problem. This is done to exploit the sparsity of the signals using the ℓ1-norm. We propose to use the Gini Index as a sparsity measure. In this work we demonstrate that this index allow to further increase the under-sampling factor. Interestingly this non-linear index can be computed by solving iteratively reweighted ℓ1 problems, without excessive computational load.}
}
@inproceedings{ISMRM2018_3533,
annote={ISMRM2018_3533},
pages={3533},
file={ISMRM2018_3533.pdf:ISMRM2018_3533.pdf:PDF},
title={Robust Autocalibrated {LORAKS} for Improved {EPI} Ghost Correction with Structured Low-Rank Matrix Models},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3533.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Rodrigo A Lobos and Ahsan Javed and Krishna S Nayak and W Scott Hoge and Justin P Haldar},
abstract={The presence of ghost artifacts is a recurrent problem in EPI images, which has been recently addressed using structured low-rank matrix (SLM) methods. In this work we propose a new SLM ghost correction method called Robust Autocalibrated LORAKS (RAC-LORAKS). RAC-LORAKS considers autocalibrated k-space constraints (similar to GRAPPA) to deal with the ill-posedness of existing SLM EPI ghost correction methods. RAC-LORAKS additionally adapts these constraints to enable robustness to possible imperfections in the autocalibration data. We illustrate the capabilities of RAC-LORAKS in two challenging scenarios: highly accelerated EPI of the brain and cardiac EPI with double-oblique slice orientation.}
}
@inproceedings{ISMRM2018_3534,
annote={ISMRM2018_3534},
pages={3534},
file={ISMRM2018_3534.pdf:ISMRM2018_3534.pdf:PDF},
title={Compressive Sensing Reconstruction for Multi-Contrast Data with Unequal Acceleration Rates},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3534.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Emre Kopanoglu and Alper Güngör and Toygan Kilic and Emine Ulku Saritas and Tolga Çukur and H. Emre Guven},
abstract={In multi-contrast acquisitions, a critical concern is whether to distribute undersampling uniformly or unequally across contrasts, as scan times and SNR typically vary among sequences. This study investigates a compressive sensing framework in jointly reconstructing multi-contrast data with unequal acceleration rates. Using in-vivo and numerical datasets, the total scan time was fixed and acceleration factors were varied between protocols. The results suggest using lower acceleration rates for protocols with higher-SNR and shorter duration and higher rates for protocols with lower-SNR and longer duration improves image quality, even in the highly accelerated contrast. The method was also compared to seven state-of-the-art methods from the literature.}
}
@inproceedings{ISMRM2018_3535,
annote={ISMRM2018_3535},
pages={3535},
file={ISMRM2018_3535.pdf:ISMRM2018_3535.pdf:PDF},
title={Joint Sparse Reconstruction of Multi-contrast {MRI} Images with Graph Wavelets},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3535.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Zongying Lai and Xinlin Zhang and Di Guo and Xiaofeng Du and Zhong Chen and Xiaobo Qu},
abstract={Multi-contrast images in magnetic resonance imaging (MRI) are widely applied in clinical applications, since an abundant contrast information reflects the characteristics of the internal tissue of human body, providing an effective reference for clinical diagnosis. However, long acquisition time limits the application of magnetic resonance multi contrast imaging. Under-sampling the k-space data and reconstructing images with sparsity constraint is one efficient way to accelerate magnetic resonance imaging sampling. In this work, multi-contrast undersampled MRI images are jointly reconstructed under the sparse representation using graph wavelets. Experiment results demonstrate that the proposed method outperforms the compared state-of-the-art methods.}
}
@inproceedings{ISMRM2018_3536,
annote={ISMRM2018_3536},
pages={3536},
file={ISMRM2018_3536.pdf:ISMRM2018_3536.pdf:PDF},
title={Feasibility of High Spatial and Temporal Resolution Breast {DCE}-{MRI} using Radial Acquisition with Data-Driven Model Consistency Condition Reconstruction},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3536.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Pingni Wang and Roberta M Strigel and Julia V Velikina and Alexey A Samsonov and Leah C Henze Bancroft and Kang Wang and Ty A Cashen and Kevin M Johnson and James H Holmes},
abstract={Dynamic contrast-enhanced (DCE) MRI using conventional Cartesian sampling is used in routine clinical practice due to its high sensitivity for breast cancer. However, ghosting artifacts caused by cardiac motion can obscure the axilla, making interpretation of this area more difficult and potentially obscuring findings. Radial acquisitions are less motion sensitive due to more frequent sampling of the center of k-space and prior work has suggested these methods for breast MRI. In this study, we report results from a reader study to assess image quality of a 3D stack-of-stars radial acquisition compared with Cartesian imaging for breast MRI.}
}
@inproceedings{ISMRM2018_3537,
annote={ISMRM2018_3537},
pages={3537},
file={ISMRM2018_3537.pdf:ISMRM2018_3537.pdf:PDF},
title={The influence of Sampling on Compressed Sensing accelerated high resolution Vessel Wall Imaging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3537.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Sen Jia and Jing Cheng and Lei Zhang and Xin Liu and Dong Liang},
abstract={This study aims to accelerate high resolution whole brain and neck vessel wall imaging using combined Compressed Sensing and Parallel Imaging. The influence of sampling choices with different control of sampling density and randomness on CSPI reconstruction were investigated on retrospectively and prospectively accelerated in vivo datasets, with emphasis on the sharpness of vessel wall borders which was critically demanded by detecting potential vessel wall thickening and atherosclerotic plaques for ischemic stroke patients.}
}
@inproceedings{ISMRM2018_3538,
annote={ISMRM2018_3538},
pages={3538},
file={ISMRM2018_3538.pdf:ISMRM2018_3538.pdf:PDF},
title={Evaluation of Sparse Sampling for Improved Image Quality of 19F Fluorinated Gas Lung Ventilation {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3538.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Adam Maunder and Guilhem Collier and Fraser Robb and Madhwesha Rao and Jim Wild},
abstract={In an effort to improve image SNR per unit time and effective resolution in
F-fluorinated gas ventilation imaging the application of compressed sensing was investigated. Simulations of sparse sampling were performed using a 3D
He ventilation imaging dataset as a gold standard. Sparse and fully sampled image fidelity was quantified by the mean-square error and coefficient of variation of signal intensity. Simulations of low resolution and sparsely sampled images with equivalent acceleration factor were also compared. Based on the simulations prospective lung images using sparse sampling with C
gas were then acquired in a healthy volunteer with acceleration factor of 4.}
}
@inproceedings{ISMRM2018_3539,
annote={ISMRM2018_3539},
pages={3539},
file={ISMRM2018_3539.pdf:ISMRM2018_3539.pdf:PDF},
title={On the importance of adapting compressed sensing for images with significant spatial phase variations},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3539.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jérémie P. Fouquet and Michael Paquette and Réjean Lebel and Maxime Descoteaux and Martin Lepage},
abstract={We explore the limits of compressed sensing (CS) in the practical setting of T2*-weighted imaging of the brain. Surprisingly, those limits are rapidly reached due in part to the presence of spatial phase variations. While conventional CS performs well for synthetic phase-free images, it is equally performant to or even outperformed by a simple zero-padding of the k-space center for acquired complex-valued images. Clearly, CS must be adapted to images including spatial phase variations and our results point toward new solutions to achieve this adaptation.}
}
@inproceedings{ISMRM2018_3540,
annote={ISMRM2018_3540},
pages={3540},
file={ISMRM2018_3540.pdf:ISMRM2018_3540.pdf:PDF},
title={Evaluating the Normalised Iterative Hard Thresholding Algorithm for Compressed Sensing Reconstruction on 7T Cardiac cine {MRI}.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3540.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Sofia Dimoudi and Matthew D Robson and Jared Tanner and Aaron T Hess},
abstract={We present our updated results in the evaluation of the Normalised Iterative Hard Thresholding Algorithm (NIHT) for parallel imaging and compressed sensing reconstructions of highly accelerated Cardiac cine MRI at 7 Tesla. We compare imaging performance with three other parallel imaging and compressed sensing methods, including regularisation in the temporal dimension.}
}
@inproceedings{ISMRM2018_3541,
annote={ISMRM2018_3541},
pages={3541},
file={ISMRM2018_3541.pdf:ISMRM2018_3541.pdf:PDF},
title={3D Real-Time {MRI} of Vocal Tract Shaping},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3541.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yongwan Lim and Yinghua Zhu and Sajan Goud Lingala and Dani Byrd and Shrikanth S Narayanan and Krishna S Nayak},
abstract={We demonstrate a new three-dimensional (3D) real-time MRI technique for the study of dynamic vocal tract shaping during human speech production. This, for the first time, enables a comprehensive assessment of vocal tract area function dynamics. We used a minimum-phase 3D slab excitation, stack-of-spirals gradient echo sequence, pseudo golden-angle view order in kx-ky, linear Cartesian order along kz and sparse SENSE image reconstruction with spatiotemporal finite difference constraints. This provides 2.4 x 2.4 x 5.8 mm
field-of-view, which covers the entire adult human vocal tract.}
}
@inproceedings{ISMRM2018_3542,
annote={ISMRM2018_3542},
pages={3542},
file={ISMRM2018_3542.pdf:ISMRM2018_3542.pdf:PDF},
title={Accelerated volumetric renal perfusion using pseudo-continuous {ASL} and a 3D Fast-Spin-Echo readout with Compressed Sensing},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3542.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Manuel Taso and Li Zhao and Arnaud Guidon and Daniel V. Litwiller and David C. Alsop},
abstract={While ASL is a promising technique to measure renal perfusion in multiple applications, its translation into clinical practice is still challenged by its motion-sensitivity and limited spatial coverage. In the current work, we propose an implementation of an undersampled Cartesian 3D-FSE readout with pseudo-continuous ASL labeling and Compressed-sensing reconstruction for fast whole kidney perfusion measurement. Results show that even at high acceleration factors (≈15), acceptable quality whole kidney ASL images could be obtained in less than a minute with increased motion-robustness. Furthermore, the CS acceleration enables acquiring multiple averages, providing increased coverage with similar SNR than mostly used 2D readouts.}
}
@inproceedings{ISMRM2018_3543,
annote={ISMRM2018_3543},
pages={3543},
file={ISMRM2018_3543.pdf:ISMRM2018_3543.pdf:PDF},
title={Rapid Parallel {MRI} Reconstruction Utilizing the Wavelet Filter Bank},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3543.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Efrat Shimron and Andrew G. Webb and Haim Azhari},
abstract={A novel method for reconstruction from highly undersampled parallel MRI data is proposed. The method computes the Stationary Wavelet Transform (SWT) of the unknown MR image directly from sub-sampled k-space measurements and then recovers the image using the Inverse SWT filter bank. Experiments with in-vivo data show that this method produces high quality reconstructions, comparable to Compressed Sensing (CS) reconstructions. However, unlike CS, the proposed method is non-iterative. Moreover, it is simple, fast and allows flexible (random or ordered) k-space undersampling schemes.}
}
@inproceedings{ISMRM2018_3544,
annote={ISMRM2018_3544},
pages={3544},
file={ISMRM2018_3544.pdf:ISMRM2018_3544.pdf:PDF},
title={Accelerating Compressed Sensing in Cartesian Parallel Imaging Reconstructions using an Efficient and Effective Circulant Preconditioner},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3544.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jeroen van Gemert and Kirsten Koolstra and Peter Börnert and Andrew Webb and Rob Remis},
abstract={Reconstruction methods in parallel imaging and compressed sensing problems are generally very time consuming, especially for a large number of coil elements. In this work, the image is reconstructed using the Split Bregman algorithm (SB). We present an efficient and effective preconditioner that reduces the number of iterations in the linear least squares step of SB by almost a factor of 5 as alternative to extra variable splitting. The designed preconditioner works for Cartesian sampling schemes and for different coil configurations. It has negligible initialization time and leads to an overall speedup factor of 2.5.}
}
@inproceedings{ISMRM2018_3545,
annote={ISMRM2018_3545},
pages={3545},
file={ISMRM2018_3545.pdf:ISMRM2018_3545.pdf:PDF},
title={Synergistic reconstruction of undersampled multi-contrast {MRI} using weighted quadratic priors},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3545.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={ABOLFAZL MEHRANIAN and Claudia Prieto and Radhouene Neji and Colm J. McGinnity and Alexander J. Hammers and Andrew J. Reader},
abstract={We propose a simple and robust methodology for synergistic multi-contrast MR image reconstruction to improve image quality of undersampled MR data beyond what is achieved from conventional independent reconstruction methods. The advantages of the proposed methodology are threefold: i) it exploits quadratic priors that are mutually weighted using all available MR images, leading to preservation of unique features, ii) the weighting coefficients are independent of the relative signal intensity and contrast of different MR images and iii) the algorithm is based on a well-established parallel imaging iterative reconstruction, which makes the synergistic reconstruction of undersampled MR data clinically feasible}
}
@inproceedings{ISMRM2018_3546,
annote={ISMRM2018_3546},
pages={3546},
file={ISMRM2018_3546.pdf:ISMRM2018_3546.pdf:PDF},
title={Parallel imaging compressed sensing for {MRI}-only radiation dosimetry of post-implant prostate cancer brachytherapy},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3546.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jeremiah Sanders and Steven Frank and Hao Song and Paula Berner and Aradhana Venkatesan and Jingfei Ma},
abstract={Researchers recently demonstrated that both anatomical structures and implanted radioactive seeds can be visualized with high-resolution balanced steady-state free precession (bSSFP) imaging using positive-MRI-signal seed markers and an endorectal coil (ERC). However, ERC use is limited by cost, patient intolerance and low clinical throughput. A previous preliminary study demonstrated that imaging without an ERC resulted in reduced image signal-to-noise ratio and reduced seed detection. In the current study, we investigated the feasibility of using parallel imaging compressed sensing to substantially accelerate the bSSFP acquisition and potentially enable MRI-only dosimetry of post-implant prostate cancer brachytherapy without an ERC.}
}
@inproceedings{ISMRM2018_3547,
annote={ISMRM2018_3547},
pages={3547},
file={ISMRM2018_3547.pdf:ISMRM2018_3547.pdf:PDF},
title={Self-calibrating nonlinear {MR} image reconstruction algorithms for variable density sampling and parallel imaging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3547.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Loubna EL GUEDDARI and Carole LAZARUS and Hanaé CARRIE and Alexandre VIGNAUD and Philippe CIUCIU},
abstract={Compressed Sensing has allowed a significant reduction of acquisition times in MRI. However, to maintain high signal-to-noise ratio during acquisition, CS is usually combined with parallel imaging (PI). Here, we propose a new self-calibrating MRI reconstruction framework that handles non-Cartesian CS and PI. Sensitivity maps are estimated from the data in the center of k-space while MR images are iteratively reconstructed by minimizing a nonsmooth criterion using the proximal optimized gradient method, which converges faster than FISTA. Comparison with L1-ESPIRiT suggests that our approach performs better both visually and numerically on 8-fold accelerated Human brain data collected at 7 Tesla.}
}
@inproceedings{ISMRM2018_3548,
annote={ISMRM2018_3548},
pages={3548},
file={ISMRM2018_3548.pdf:ISMRM2018_3548.pdf:PDF},
title={Locally Low Rank Regularization for Magnetic Resonance Fingerprinting},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3548.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Gastao Cruz and Aurelien Bustin and Olivier Jaubert and Torben Schneider and René M Botnar and Claudia Prieto},
abstract={Magnetic Resonance Fingerprinting (MRF) estimates simultaneous, multi-parametric maps from a dynamic series of highly undersampled time-point images. At very high undersampling factors, some of these artefacts may propagate into the parametric maps leading to errors. Here we propose the use of locally low rank regularization for a low rank approximation reconstruction to enable highly accelerated MRF. The proposed approach was evaluated in simulations and in-vivo brain acquisitions. Results show that the proposed approach enables accurate MRF reconstructions from ~600 time-point images with one radial spoke per time-point.}
}
@inproceedings{ISMRM2018_3549,
annote={ISMRM2018_3549},
pages={3549},
file={ISMRM2018_3549.pdf:ISMRM2018_3549.pdf:PDF},
title={Accelerating T2 Mapping Using a Self-trained Kernel {PCA} Model},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3549.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Chaoyi Zhang and Ukash Nakarmi and Hongyu Li and Yihang Zhou and Dong Liang and Leslie Ying},
abstract={Kernel Principal component analysis(KPCA) model has recently been proposed to accelerate dynamic cardiac imaging. In this abstract, we study the effectiveness of KPCA for MR T2 mapping from highly under-sampled data acquired at different echo time. Different from dynamic cardiac imaging where only morphological information is needed, the quantitative values are highly important in parameter mapping. Here we use a self-trained KPCA model to guarantee the accuracy of the reconstructed T2 maps. The experimental results show that the proposed method can recover the T2 map with high fidelity at high acceleration factors.}
}
@inproceedings{ISMRM2018_3550,
annote={ISMRM2018_3550},
pages={3550},
file={ISMRM2018_3550.pdf:ISMRM2018_3550.pdf:PDF},
title={Accelerated real-time spiral {MRI} for high-resolution velum imaging using low rank and sparse decomposition and Chebyshev based off-resonance correction},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3550.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Xue Feng and Catherine M Pelland and Silvia S Blemker and Craig H Meyer},
abstract={In this study, an accelerated real-time spoiled spiral GRE sequence was developed for high-resolution velum imaging during speech to evaluate VPI. The low rank plus sparse decomposition was used to reconstruction highly undersampled (6x) dynamic image series. Chebysheve based off-resonance correction was used to reduce local blurring around velum after L+S reconstruction. The developed method generated high quality dynamic images with minimal temporal blurring and reduced blurring at 1.5 T, which can then be used to track velum movements for further analysis.}
}
@inproceedings{ISMRM2018_3551,
annote={ISMRM2018_3551},
pages={3551},
file={ISMRM2018_3551.pdf:ISMRM2018_3551.pdf:PDF},
title={Highly Accelerated 3D Chemical-Shift Magnetic Resonance Imaging Using 4D Compressed Sensing},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3551.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jian-xiong Wang and Xiaodong Wen and Crystal Harrison and A Dean Sherry and Craig R Malloy},
abstract={Compressed Sensing method using 4D operators and functions to treat the entire 4D data as unity can perform high reduction rate of acceleration and preserve excellent data fidelity. This work demonstrated its effectiveness on 3D chemical-shift-imaging with reduction rate R=16 or 6.25\% sampling ratio and up to R=32 or 3.125\% sampling ratio. The method has been implemented onto MRI scanner for real-time sparse 3D CSI acquisition. The excellent data fidelity are demonstrated with 3D CSI images of phantom and in-vivo hyperpolarized [1-
C]pyruvate and its production metabolites.}
}
@inproceedings{ISMRM2018_3552,
annote={ISMRM2018_3552},
pages={3552},
file={ISMRM2018_3552.pdf:ISMRM2018_3552.pdf:PDF},
title={{MR} image reconstruction using the Chambolle-Pock algorithm},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3552.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jing Cheng and Sen Jia and Haifeng Wang and Dong Liang},
abstract={The combination of Parallel imaging (PI) and compressed sensing (CS) allow high quality MR image reconstruction from partial k-space data. However, most CS-PI MRI methods suffer from detail loss with large acceleration and complicated parameter selection. In this work, we describe and evaluate an efficient and robust algorithm to overcome these limitations. The experimental results on in vivo data show that, the proposed method using a first-order primal-dual algorithm can successfully remove undersampling artifacts while keeping the details with little parameter tuning compared with the existing advanced method.
}
}
@inproceedings{ISMRM2018_3553,
annote={ISMRM2018_3553},
pages={3553},
file={ISMRM2018_3553.pdf:ISMRM2018_3553.pdf:PDF},
title={A Late-Stage Deuteration Method for T1 Prolongation and Enhanced In Vivo Signal to Noise Ratio of Hyperpolarized 13C Substrates},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3553.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Céline Taglang and David E. Korenchan and Cornelius von Morze and Chloé Najac and Joseph E. Blecha and Justin Yu and Sukumar Subramaniam and Robert Bok and Henry VanBrocklin and Renuka Sriram and John Kurhanewicz and David M. Wilson and Robert R. Flavell},
abstract={One of the fundamental limitations of hyperpolarized
13C technology is the effective lifetime of the signal, which decays in keeping with the spin-lattice relaxation constant T
1. We have developed a robust late stage deuteration methodology which is broadly applicable to amino and alpha hydroxyl acids, including commonly used probes such as alanine and lactate. This methodology enables significant T
1 prolongation, yielding an effective doubling of in vivo signal to noise ratio at relevant imaging time-points. We tested [1-
13C, 2-
2H]alanine prepared via this method both in vitro and in vivo. This broadly applicable methodology may facilitate implementation and translation of hyperpolarized
13C MRI probes.}
}
@inproceedings{ISMRM2018_3554,
annote={ISMRM2018_3554},
pages={3554},
file={ISMRM2018_3554.pdf:ISMRM2018_3554.pdf:PDF},
title={Spiral-In/Out Multi Spin-Echo Acquisitions for Increased {SNR} in Dynamic Hyperpolarized
13C {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3554.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Shuyu Tang and Robert Bok and Eugene Milshteyn and Daniel Vigneron and Peder Larson},
abstract={The long T2 relaxation time of hyperpolarized
13C-labeled metabolites at 3T allows efficient use of hyperpolarized signal by multi spin-echo readouts. This work presents a novel
13C sequence that uses spiral in/out acquisitions at multiple spin echoes, each formed by a single adiabatic pulse to improve signal-to-noise ratio(SNR) in dynamic hyperpolarized
13C MRI. The proposed sequence was tested in vivo on a normal rat on a clinical 3T scanner. Results show that the proposed method has improved SNR for 15 dynamic acquisitions over 30s.}
}
@inproceedings{ISMRM2018_3555,
annote={ISMRM2018_3555},
pages={3555},
file={ISMRM2018_3555.pdf:ISMRM2018_3555.pdf:PDF},
title={Developing a Regional Bolus Tracking and Real-time B
1 Calibration Method for Hyperpolarized
13C {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3555.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Shuyu Tang and Eugene Milshteyn and Galen Reed and Jeremy Gordon and Robert Bok and Daniel B. Vigneron and Peder Larson},
abstract={Acquisition timing and B
1 calibration are two key factors that affect the quality and accuracy of hyperpolarized
13C MRI. This project developed a new approach using regional bolus tracking to trigger Bloch-Siegert B
1 mapping and real-time regional RF power compensation, followed by dynamic imaging of hyperpolarized
13C metabolites. The feasibility of applying the proposed framework for in vivo hyperpolarized
13C imaging was demonstrated on healthy rats and tumor-bearing mice on a clinical 3T scanner. This proposed method was designed to improve efficient use of hyperpolarized magnetization as well as the accuracy and robustness of hyperpolarized
13C MRI.}
}
@inproceedings{ISMRM2018_3556,
annote={ISMRM2018_3556},
pages={3556},
file={ISMRM2018_3556.pdf:ISMRM2018_3556.pdf:PDF},
title={A perfused heart system to simulate first pass observation of rat cardiac metabolism with hyperpolarized [1-¹³C]pyruvate and determination of {LDH} flux using selective excitation},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3556.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Gal Sapir and Talia Harris and Assad Azar and Atara Nardi-Schreiber and Ayelet Gamliel and Jacob Sosna and Moshe J. Gomori and Rachel Katz-Brull},
abstract={Aberrant cardiac metabolism is linked to major health issues in the Western world including diabetes and heart failure. New tools are needed to investigate these conditions and to allow better diagnosis. In this work we used dissolution dynamic nuclear polarization NMR spectroscopy (dDNP-NMR) to investigate [1-
13C]pyruvate metabolism in the isolated rat heart. A perfusion system simulating in vivo first-pass hemodynamics was used to measure the enzymatic flux through lactate dehydrogenase (LDH) using product selective excitation. LDH flux was found to be 52 ± 8 nmol lactate/s/g wet weight (n=3).}
}
@inproceedings{ISMRM2018_3557,
annote={ISMRM2018_3557},
pages={3557},
file={ISMRM2018_3557.pdf:ISMRM2018_3557.pdf:PDF},
title={The effect of ¹H-decoupling on hyperpolarized ¹³C signal decay – a study on choline chloride analogs and comparison to the effect of deuterium substitution of directly bonded protons},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3557.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Sivaranjan Uppala and Gamliel Ayelet and Atara Nardi Schreiber and Talia Harris and Jacob Sosna and J. Moshe Gomori and Rachel Katz-Brull},
abstract={The spin-lattice relaxation time (T
1) of a DNP molecular probe is a key parameter in acquiring NMR signals in dissolution-DNP (d-DNP) experiments. Using molecular probes with long T
1, NMR spin signals can survive for a duration sufficient for the study of metabolism (1-3 min). Deuteration of directly bonded
13C protonated positions has been useful in prolonging the visibility of hyperpolarized labeled
13C sites that are otherwise protonated. Here, we sought to investigate whether proton irradiation could affect the T
1 of such
13C nuclei when such positions are in their naturally abundant form, i.e. directly bonded to protons.}
}
@inproceedings{ISMRM2018_3558,
annote={ISMRM2018_3558},
pages={3558},
file={ISMRM2018_3558.pdf:ISMRM2018_3558.pdf:PDF},
title={Optimizing signal-to-noise ratio for hyperpolarized carbon-13 magnetic resonance imaging using a hybrid flip angle scheme},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3558.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Lauren Smith and Trevor Wade and Alireza Akbari and Conrad Rockel and Lanette Friesen-Waldner and Charles McKenzie},
abstract={Hyperpolarized 13C imaging can provide useful metabolic information; however, rapid decay of hyperpolarized signal leads to reduced signal-to-noise ratio (SNR) images. We demonstrate an RF excitation scheme that dynamically changes the RF spectral profile and amplitude to achieve flip angles that vary throughout the acquisition independently for each metabolite. This preserves signal during a dynamic imaging experiment maintaining more signal for later time-points than using a constant RF pulse. Increased in vivo SNR at later time points of [1-13C]pyruvate and its metabolites was shown by dynamic imaging experiments in guinea pigs with both constant and variable flip angle schemes.}
}
@inproceedings{ISMRM2018_3559,
annote={ISMRM2018_3559},
pages={3559},
file={ISMRM2018_3559.pdf:ISMRM2018_3559.pdf:PDF},
title={Optimized Single Shot 3D Sequence for High Resolution Hyperpolarized 13C Imaging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3559.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jiazheng Wang and Richard L Hesketh and Alan J Wright and Kevin M Brindle},
abstract={We have developed a single-shot 3D sequence for hyperpolarized
13C MRI, which uses a spatial-spectral (SpSp) pulse for excitation, a train of adiabatic pulses for refocusing and a stack-of-spirals acquired through a fast-spin-echo train. The sequence achieved an isotropic image resolution of 1.25x1.25x1.25 mm
3 in vivo on a 7 T animal system, where hyperpolarized [1-
13C]pyruvate and [1-
13C]lactate were imaged alternately at a frame rate of 2 s per metabolite. Signals from extra spirals acquired from later spin echoes were averaged with those from the early echoes to give a high signal-to-noise ratio (SNR) as well as high spatial resolution.}
}
@inproceedings{ISMRM2018_3560,
annote={ISMRM2018_3560},
pages={3560},
file={ISMRM2018_3560.pdf:ISMRM2018_3560.pdf:PDF},
title={Multichannel Hyperpolarized 13C {MRI} in a Patient with Liver Metastases using Multi-slice {EPI} and an Alternating Projection Method for Denoising},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3560.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Rie B Hansen and Jeremy W Gordon and Peter J Shin and Zihan Zhu and Daniele Mammoli and Pamela N Munster and Rahul Aggarwal and Michael A Ohliger and Peder EZ Larson and Lars G Hanson and Jan H Ardenkjær-Larsen and Daniel B Vigneron},
abstract={Hyperpolarized
13C-pyruvate for monitoring metabolism of liver metastases in vivo is being investigated for clinical trials of new therapeutics. This study applied advances in multichannel receive arrays and sequence design for human
13C liver imaging and investigated a new denoising method. The method is based on an alternating projection method to enforce structuredness and low-rankness and is applied with automatic threshold estimation. In vivo data demonstrate improved quality of kinetic modeling after denoising. However, simulations revealed certain unresolved pitfalls.}
}
@inproceedings{ISMRM2018_3561,
annote={ISMRM2018_3561},
pages={3561},
file={ISMRM2018_3561.pdf:ISMRM2018_3561.pdf:PDF},
title={Slice Profile Induced Errors in Metabolic Quantification of Hyperpolarized Pyruvate.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3561.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Christopher M Walker and James A Bankson},
abstract={Hyperpolarized pyruvate is being explored as a quantitative imaging biomarker of metabolism. Non-ideal slice excitation of hyperpolarized magnetization can result in temporally evolving slice profiles. This work evaluates the impact of slice profile on quantitative analysis of hyperpolarized pyruvate using a perfused Bloch-McConnell simulator. Results indicate that the slice profile can cause significant bias in the measured apparent metabolic exchange constant. Primary sources of bias are excesssignal from the slice penumbra and the offset between metabolite slices. Therefore, it will be critical to properly account for the slice profile when attempting to quantify hyperpolarized signal using slice selective excitations.}
}
@inproceedings{ISMRM2018_3562,
annote={ISMRM2018_3562},
pages={3562},
file={ISMRM2018_3562.pdf:ISMRM2018_3562.pdf:PDF},
title={Improving robustness of hyperpolarized
13C {MRSI} using k-t spiral acquisitions},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3562.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Erin Adamson and Benjamin Cox and Sean Fain},
abstract={Hyperpolarized
13C MRSI with chemical shift encoding relies on a priori knowledge of the N
13C-labeled metabolite resonances and N+1 echoes to fully determine the reconstruction. However, the a priori frequencies may shift due to B
0 inhomogeneity, local susceptibilities, or motion, causing spectral leakage, blurring and biased quantitative measures. To address these uncertainties, we apply IDEAL-based k-t spiral imaging with field-of-view oversampling to further constrain the signal model-based reconstruction in situations where the echo-spacing may be suboptimal and we test the results in digital simulations, phantom experiments and in vivo studies of murine renal metabolism. Results support improved metabolic quantification.}
}
@inproceedings{ISMRM2018_3563,
annote={ISMRM2018_3563},
pages={3563},
file={ISMRM2018_3563.pdf:ISMRM2018_3563.pdf:PDF},
title={Mitigating Chemical Exchange Effects in Advanced Pulse Sequences for pH Imaging with Hyperpolarized [13C]bicarbonate},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3563.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={David E Korenchan and Jeremy W Gordon and Sukumar Subramaniam and Renuka Sriram and Peder E Z Larson and Robert R Flavell and John Kurhanewicz},
abstract={Imaging extracellular acidification in tumors will likely lead to better characterization of tumor aggressiveness and treatment efficacy. Hyperpolarized (HP) [
13C]bicarbonate magnetic resonance spectroscopic imaging (MRSI) can map pH in murine tumors, but images generally suffer from low signal-to-noise ratio (SNR) and coarse spatial resolution. Although sophisticated pulse sequences can boost SNR, pH accuracy can be compromised due to bidirectional [
13C]bicarbonate <->
13CO
2 chemical exchange during imaging. We investigated several pulse sequences and excitation/refocusing schemes and a modified 2D echo-planar imaging sequence with spectral-spatial excitation demonstrated the best combination of spatial resolution, pH accuracy and potential for future clinical implementation.}
}
@inproceedings{ISMRM2018_3564,
annote={ISMRM2018_3564},
pages={3564},
file={ISMRM2018_3564.pdf:ISMRM2018_3564.pdf:PDF},
title={Modeling In Vivo Metabolism of Hyperpolarized Pyruvate in Human Brain Tumor Patients.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3564.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Daniele Mammoli and Jeremy Gordon and Adam Autry and Peder EZ Larson and Hsin-Yu Chen and Mark Van Criekinge and Lucas Carvajal and Ilwoo Park and James B Slater and Robert Bok and Jason Crane and Markus Ferrone and John Kurhanewicz and Susan Chang and Daniel B Vigneron},
abstract={We show preliminary results of hyperpolarized [1-
13C]pyruvate injected in 9 patients affected with glioma. Raw data showed excellent SNR. Variable bolus delivery and magnitude images introduced errors in modeling the conversion of pyruvate into lactate: kinetic models were presented and compared quantitatively to address these issues. Finally, reliable and spatially-resolved maps of k
PL rates were obtained, which can be useful in future to assess the clinical relevance of the method for both diagnosis and response to therapy.}
}
@inproceedings{ISMRM2018_3565,
annote={ISMRM2018_3565},
pages={3565},
file={ISMRM2018_3565.pdf:ISMRM2018_3565.pdf:PDF},
title={Comparison between 8- and 32-channel phased-array receive coils for in vivo hyperpolarized C-13 brain imaging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3565.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Adam Autry and Jeremy W Gordon and Lucas Carvajal and Ilwoo Park and Daniele Mammoli and Hsin-Yu Chen and Susan Chang and Yan Li and Duan Xu and Daniel Vigneron and Sarah J Nelson},
abstract={This study sought to evaluate the performance of the first 32-channel head coil for in vivo hyperpolarized
13C brain imaging by comparison against a conventional 8-channel receiver array. Initial phantom experiments characterized the B
1+ homogeneity and SNR profiles associated with each hardware configuration via EPI-based imaging techniques. As part of a clinical trial, in vivo dynamic EPI data were also acquired from patients with brain tumors. Phantom and patient data revealed improved uniformity, coverage and SNR with the 32-channel array that will promote higher resolution and acceleration. In vivo data also demonstrated unprecedented detection of bicarbonate using both hardware platforms.}
}
@inproceedings{ISMRM2018_3566,
annote={ISMRM2018_3566},
pages={3566},
file={ISMRM2018_3566.pdf:ISMRM2018_3566.pdf:PDF},
title={Probing renal pH and aminopeptidase N activity with hyperpolarized [1-13C]alaninamide},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3566.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Alice Radaelli and Hikari Ananda Infinity Yoshihara and Ryunosuke Hata and Shinsuke Sando and Rolf Gruetter},
abstract={The detection of aminopeptidase N (APN) activity can give information on tumor development. Hyperpolarized L-[1-
13C]alaninamide is a specific, sensitive probe of APN activity in kidney homogenate. Here, we characterized its in vivo metabolic response in the rat kidney. In addition to being an APN substrate, L-[1-
13C]alaninamide is sensitive to pH and also reacts with dissolved carbon dioxide. To avoid spectral overlap, alaninamide is best suited as an APN probe in acidic environments and it may have additional applications as a multifunctional sensor of pH and CO
2.}
}
@inproceedings{ISMRM2018_3567,
annote={ISMRM2018_3567},
pages={3567},
file={ISMRM2018_3567.pdf:ISMRM2018_3567.pdf:PDF},
title={Susceptibility-Induced Distortion Correction in Hyperpolarized Echo Planar Imaging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3567.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jack J J J Miller and Angus Z Lau and Damian J Tyler},
abstract={Echo Planar Imaging is an attractive rapid imaging readout that can image hyperpolarized compounds in vivo. By alternating the sign of the phase encoding gradient waveform, spatial offsets arising from uncertain frequency shifts can be determined. We show here that blip-reversed EPI can also be used to correct for susceptibility and $B_0$ inhomogeneity effects that would otherwise produce image-domain distortion in the heart, through the use of an estimated deformation field that is calculated from the acquired data.}
}
@inproceedings{ISMRM2018_3568,
annote={ISMRM2018_3568},
pages={3568},
file={ISMRM2018_3568.pdf:ISMRM2018_3568.pdf:PDF},
title={Extended Signal Modelling and Regularization for Multi-Echo Hyperpolarized Metabolic Image Reconstruction},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3568.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Julia Busch and Valeriy Vishnevskiy and Maximilian Fuetterer and Claudio Santelli and Constantin von Deuster and Sophie Marie Peereboom and Mareike Sauer and Thea Fleischmann and Nikola Cesarovic and Christian Torben Stoeck and Sebastian Kozerke},
abstract={The IDEAL signal model for hyperpolarized metabolic imaging is extended and spatiotemporal regularization and b0-map recalibration is included. The approach is tested on simulated data and in-vivo metabolic imaging data of the heart. Allowing variable b0-fields and including sparsity regularization signal leakage and ghosting can be significantly reduced (average reduction of root-mean-square error (RMSE) by 16\% and 30\%). Spatial and temporal regularization of the metabolite intensities considerably improved accuracy of the estimate in terms of RMSE with additional reductions by 68\% and 20\%, respectively. Thus, the metabolic conversion of [1-13C]pyruvate into [1-13C]lactate and 13C-bicarbonate can be measured with improved accuracy.}
}
@inproceedings{ISMRM2018_3569,
annote={ISMRM2018_3569},
pages={3569},
file={ISMRM2018_3569.pdf:ISMRM2018_3569.pdf:PDF},
title={Combined {FDG}-{PET} and hyperpolarized pyruvate-{MRSI} (hyper{PET}) for cancer metabolic phenotyping – a pilot study},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3569.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Sissel Bisgaard and Andreas Ettrup Clemmensen and Abubakr Eldirdiri and Helle Hjorth Johannesen and Jan Henrik Ardenkjær-Larsen and Adam Espe Hansen and Andreas Kjær},
abstract={Molecular imaging of cancer metabolism in vivo is increasingly employed in clinical settings. Both
18F-FDG PET and hyperpolarized [1-
13C]pyruvate MRSI are sensitive to glucose metabolism but differ in which part of the glycolytic pathway is probed. We hypothesize that hyperPET may improve cancer specific metabolic phenotyping. Simultaneous
18F-FDG PET and hyperpolarized [1-
13C]pyruvate MRSI (hyperPET) was used in a pilot study, examining the metabolic characteristics exhibited by four different cancer cell lines in nude mice. The results indicated that the combined modalities may distinguish between cancer types.}
}
@inproceedings{ISMRM2018_3570,
annote={ISMRM2018_3570},
pages={3570},
file={ISMRM2018_3570.pdf:ISMRM2018_3570.pdf:PDF},
title={Improved Hyperpolarized Cerebral Perfusion Imaging Using a Sucrose/Water Glassing Matrix for tert-Butanol},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3570.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Gopal Varma and Patricia Coutinho de Souza and Cody Callahan and David C Alsop and Aaron K Grant},
abstract={Perfusion imaging is a promising application for hyperpolarized tracers, as they provide high signal with no endogenous background. Hyperpolarized 13C labeled tert-butanol is a freely diffusible perfusion agent with long T1 and T2 relaxation times in vivo. Prior work has shown that tert-butanol can be polarized to 5-10\% using dynamic nuclear polarization through addition of glycerol as a glassing agent. Here we investigate a formulation based on a water/sucrose/tert-butanol mixture that yields a 1.6-fold improvement in polarization and illustrate its use in 3D cerebral perfusion imaging in rats.}
}
@inproceedings{ISMRM2018_3571,
annote={ISMRM2018_3571},
pages={3571},
file={ISMRM2018_3571.pdf:ISMRM2018_3571.pdf:PDF},
title={A robust approach to generate high polarization levels of metabolites within seconds with para-hydrogen},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3571.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Sergey Korchak and Shengjun Yang and Salvatore Mamone and Stefan Glöggler},
abstract={Hyperpolarization of metabolites is a promising approach for in vivo disease detection and observation of treatment responses.1-4 Among hyperpolarization techniques, para-hydrogen induced polarization (PHIP) represents an inexpensive approach to generate polarization within a few seconds.5-11 Here, we are introducing a pulsed magnetic resonance method to polarize metabolites that enables us to efficiently transfer proton polarization to a 13C nucleus of interest. This becomes especially possible by attaching an optimized molecular sidearm to a metabolite of choice (here: acetate, glycine and pyruvate) which is para-hydrogenated and the polarization subsequently transferred. We have achieved high levels of metabolite precursor polarization (P >10\%) with para-hydrogen within 15 seconds. Cleavage of the sidearm yields hyperpolarized metabolites.}
}
@inproceedings{ISMRM2018_3572,
annote={ISMRM2018_3572},
pages={3572},
file={ISMRM2018_3572.pdf:ISMRM2018_3572.pdf:PDF},
title={Hyperpolarization without a polarizer: in vivo 13C-{MRI} using {SAMBADENA}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3572.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Andreas B. Schmidt and Stephan Berner and Moritz Braig and Mirko Zimmermann and Jürgen Hennig and Dominik von Elverfeldt and Jan-Bernd Hövener},
abstract={Hyperpolarization (HP) enhances the sensitivity of MR by several orders of magnitude and allows the detection of metabolism non-invasively and in vivo. However, well-established methods are costly, complex and require a dedicated “polarizer” next to the MRI system. SAMBADENA is, to date, the simplest and most cost-effective method to generate
13C-HP > 20 \% for MRI. Within seconds HP is achieved within the MRI and little additional hardware is required. Here, the first in-vivo applications of SAMBADENA are reported, demonstrating its potential to be a fast, simple, low-cost alternative method for HP-MRI.}
}
@inproceedings{ISMRM2018_3573,
annote={ISMRM2018_3573},
pages={3573},
file={ISMRM2018_3573.pdf:ISMRM2018_3573.pdf:PDF},
title={Considerations for Spin Order Transfer to 13C-labeled pyruvate precursors by Parahydrogen-induced Polarization for in vivo applications},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3573.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Neil James Stewart and Mitsushi Tomohiro and Yoshiki Uchio and Kensuke Takoshima and Shingo Matsumoto},
abstract={The recent achievement of
13C-pyruvate polarization by side-arm para-hydrogen induced polarization (SA-PHIP) in-vitro has renewed interest in PHIP, which has been limited by a lack of biologically-relevant directly-polarizable compounds. To investigate the achievable polarization of
13C-pyruvate by SA-PHIP for in-vivo metabolic MRI, density matrix simulations of polarization transfer by magnetic field cycling (MFC) and spin-order transfer (SOT) pulse sequences were performed for target precursors. MFC-based approaches were confirmed to be suitable for polarization transfer over the long-range J-couplings present in SA-PHIP precursors. Additionally, simulated polarization levels with SOT approaches were reasonable for representative
13C-pyruvate precursors, promising for metabolic MRI.}
}
@inproceedings{ISMRM2018_3574,
annote={ISMRM2018_3574},
pages={3574},
file={ISMRM2018_3574.pdf:ISMRM2018_3574.pdf:PDF},
title={Feasibility of Imaging Lung Cancer Using Hyperpolarized {MRI} Technology},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3574.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Mehrdad Pourfathi and Luis Loza and Stephen Kadlecek and Ian Duncan and Diane Lim and Shampa Chatterjee and Kai Ruppert and Sarmad Siddiqui and Harrilla Profka and Yan Liu and Jessica Kim and Hooman Hamedani and Yi Xin and Faraz Amzajerdian and Maurizio Cereda and Ryan Baron and Mary Spencer and Tahmina Achekzai and Jose Conejo-Garcia and Rahim R. Rizi},
abstract={We demonstrate the feasibility of hyperpolarized MRI technology to image lung cancer in mice. We demonstrated the use of
13C MRSI to detect elevated pyruvate to lactate conversion in the tumor relative to the adjacent non-cancerous lung tissue. We also showed the feasibility of
129Xe imaging to detect non-aerated regions in the lung tissue co-localized with the tumor. The utility of these modalities combined may provide a multi-faceted tool to assess tumor's stage and its response to therapy in lung cancer.}
}
@inproceedings{ISMRM2018_3575,
annote={ISMRM2018_3575},
pages={3575},
file={ISMRM2018_3575.pdf:ISMRM2018_3575.pdf:PDF},
title={Improved Hyperpolarization of Solid and Mesoporous Nanoscale Silicon Particles Using {TEMPO} Radicals Allows In Vivo 29Si {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3575.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Nicholas Whiting and Jingzhe Hu and Shivanand Pudakalakatti and Caitlin McCowan and Hyeonglim Seo and Youngbok Lee and Pratip Bhattacharya},
abstract={Hyperpolarized silicon microparticles have been previously demonstrated as in vivo MRI contrast agents; unfortunately, their large size and decreased mobility present limitations for targeted molecular imaging. While nanoscale silicon particles can also be hyperpolarized, their signal enhancement is typically limited by a low concentration of endogenous electrons. As such, no studies to date have demonstrated in vivo
29Si MRI of hyperpolarized nano-scale silicon. We demonstrate improved
29Si hyperpolarization with the addition of an exogenous radical species to both solid and mesoporous nanoparticle samples (30-300 nm diameter), which increases
29Si hyperpolarization and allows in vivo imaging of silicon nanoparticles.}
}
@inproceedings{ISMRM2018_3576,
annote={ISMRM2018_3576},
pages={3576},
file={ISMRM2018_3576.pdf:ISMRM2018_3576.pdf:PDF},
title={Macrocyclic Xenon hosts: potential inhibitors and reporters for protein aggregation in Hyper-{CEST} {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3576.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jan Oliver Jost and Christopher Witte and Leif Schröder},
abstract={Contrast agents for neurodegenerative diseases such as amyloidosis are challenging for MRI due to sensitivity limitations. Using hyperpolarized Xenon with special Xe hosts in combination with chemical excitation saturation transfer (CEST) has the potential to overcome this issue. It has been demonstrated that Cucurbit[7]uril (CB7) is inhibiting the fibrillation of Aβ40/ Aβ42 by interaction with its Phe residues. In parallel, we have demonstrated that CB7 can be used as a Xe-host. Here we present first results for a concept that uses CB7 as a drug and Xe biosensor simultaneously where binding of CB7 to Aβ40 can be detected by changing the Xe-HyperCEST signal.
}
}
@inproceedings{ISMRM2018_3577,
annote={ISMRM2018_3577},
pages={3577},
file={ISMRM2018_3577.pdf:ISMRM2018_3577.pdf:PDF},
title={First-pass Perfusion {MRI} of Myocardial Infarction Using a Novel Manganese Chelate Contrast Agent in a Rabbit Model},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3577.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Lingyi Wen and Zhigang Yang and Hang Fu and Kun Zhang and Ran Sun and Yingkun Guo},
abstract={First-pass perfusion MRI allows evaluation of myocardial perfusion in myocardial infarction (MI). While Gd
3+-based contrast agents are incompatible with renal compromise, we designed and synthesized a novel manganese (Mn
2+ ) based contrast agents. MI was induced in 4 rabbits, Mn
2+ based and Gd
3+-based first-pass perfusion MRI were performed on a 3.0T MRI scanner. All rabbits survived without significant differences in heart rate and left ventricular function. All the perfusion parameters of infarcted and normal myocardial segments correlated well between Gd-based and Mn-based perfusion imaging. Our novel Mn
2+ contrast agents is safe and reliable to visualize myocardial perfusion in MI.}
}
@inproceedings{ISMRM2018_3578,
annote={ISMRM2018_3578},
pages={3578},
file={ISMRM2018_3578.pdf:ISMRM2018_3578.pdf:PDF},
title={Intracellular Assembly of Olsalazine Nanoparticles for {CEST} {MR} Imaging and Cancer Therapy},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3578.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yue Yuan and Xiaoliang Qi and Jia Zhang and Xiaolei Song and Michael T. McMahon and Jeff W.M. Bulte},
abstract={Based on a biocompatible condensation reaction caused by tumor-related proprotein convertase furin, we developed a novel probe
RRVR-Olsa for tumor-targeted CEST MR imaging and chemotherapy to accomplish theranostics. Our preliminary studies indicated that,
RRVR-Olsa elicited an obvious increase in CEST signal and higher cytotoxicity on furin-overexpressing HCT116 cancer cells than on furin-deficient LoVo cells and on furin inhibitor-treated HCT116 cancer cells. In vivo CEST MRI with the use of
RRVR-Olsa could readily distinguish the difference of furin expression in HCT116 tumor and LoVo tumor, which we attributed to the furin-directed intracellular self-assembly of
RRVR-Olsa to olsalazine nanoparticles with enhanced accumulation.}
}
@inproceedings{ISMRM2018_3579,
annote={ISMRM2018_3579},
pages={3579},
file={ISMRM2018_3579.pdf:ISMRM2018_3579.pdf:PDF},
title={In Vivo i{CEST} {MRI} Detection of Zinc Depletion in an Orthotopic Prostate Cancer Mouse Model},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3579.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yue Yuan and Chengyan Chu and Zhiliang Wei and Xiaolei Song and Jeff W.M. Bulte},
abstract={Prostate cancer is the only known disease of the prostate that displays such a substantial decrease in tissue zinc content and neither prostatitis nor benign prostatic hyperplasia are associated with this phenotype.
19F-based iCEST MRI probe TF-BAPTA was used to show clearly a detectable difference in zinc concentration between normal and malignant prostate cell lines and normal prostate cells with a downregulated ZIP1 transporter. Via an orthotopic prostate cancer mouse model, the feasibility of iCEST MRI to distinguish normal mouse prostate and cancerous prostate has been verified. Hence, iCEST MRI may have potential to non-invasively monitor the early malignant transformation in prostate cancer.}
}
@inproceedings{ISMRM2018_3580,
annote={ISMRM2018_3580},
pages={3580},
file={ISMRM2018_3580.pdf:ISMRM2018_3580.pdf:PDF},
title={Imaging and discrimination of extracellular lactate in vivo using {CEST} and a paramagnetic shift reagent},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3580.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Andre Martins and Lei Zhang and Veronica Clavijo-Jordan and Alexander Funk and Carlos Platas-Iglesias and A. Dean Sherry},
abstract={Glucose taken up by cancer cells is thought to be converted largely to lactate even in the presence of abundant oxygen although the amount of pyruvate diverted into the mitochondria is largely unknown. Hence, a method for imaging actual lactate production by tumors could be highly informative. We report in this work the design of several lanthanide-based shift reagents (SR) that form complexes with lactate and shift the lactate –OH CEST signal to a different frequency far away from water. Given that these SR’s are confined to extracellular space, the resulting lactate –OH CEST signal becomes a specific biomarker of lactate exported from cancer cells. This method offers great promise for imaging lactate production by tumors.}
}
@inproceedings{ISMRM2018_3581,
annote={ISMRM2018_3581},
pages={3581},
file={ISMRM2018_3581.pdf:ISMRM2018_3581.pdf:PDF},
title={Low affinity zinc sensors for improved {MRI} detection of glucose-stimulated zinc({II}) secretion from pancreatic beta-cells in vivo},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3581.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Andre F Martins and Veronica Clavijo-Jordan and Sara Chirayil and Shanrong Zhang and Namini Paranawithana and A. Dean Sherry},
abstract={We report here the design of several gadolinium-based MR contrast agents with different zinc affinities. The zinc sensors increased r
1 in the presence of Zn
2+ ions and more in the presence of serum albumin, only when zinc was present. The sensors with a lower affinity for Zn
2+ enhanced better the MR contrast produced by zinc release in mouse pancreas due to reduced background signal. These lower affinity Zn
2+ agents show great promise for detecting and monitoring the pharmacological effect of drugs in diabetes.}
}
@inproceedings{ISMRM2018_3582,
annote={ISMRM2018_3582},
pages={3582},
file={ISMRM2018_3582.pdf:ISMRM2018_3582.pdf:PDF},
title={An Elastase Activity Reporter for {EPR} and {OMRI} as a Line-Shifting Nitroxide.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3582.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Natacha Jugniot and Indranil Duttagupta and Angélique Rivot and Philippe Massot and Colleen Cardiet and Jean-Michel Franconi and Pierre Voisin and Elodie Parzy and Eric Thiaudière and Sylvain R.A Marque and Abderrazzak Bentaher and Gérard Audran and Philippe Mellet},
abstract={Neutrophils secrete proteases at inflammation sites leading to protease/inhibitor imbalance. Among them, neutrophil elastase (NE) is responsible for lung degradation via elastin fragmentation. Monitoring protease/inhibitor status non-invasively would be an important diagnostic tool. We present Meo-Suc-(Ala)2-Pro-Val-nitroxide, a line-shifting elastase activity probe for Electronic Paramagnetic Resonance (EPR) spectroscopy and Overhauser-enhanced Magnetic Resonance Imaging (OMRI). Fast and sensitive with Km= 15 ± 2.9 µM, kcat/Km= 930000 s-1.M-1, this substrate was assessed with bronchoalveolar lavage samples from Pseudomonas pneumonia mouse model. We observed a clear difference between wild type and NE deficient animals. These results can lead to new in vivo diagnostic methods and lung protection.}
}
@inproceedings{ISMRM2018_3583,
annote={ISMRM2018_3583},
pages={3583},
file={ISMRM2018_3583.pdf:ISMRM2018_3583.pdf:PDF},
title={Using single 19F-probe for multiplexed imaging with 19F-{CEST} {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3583.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ronit Shusterman-Krush and Liat Avram and Bruce C. Gibb and Amnon Bar-Shir},
abstract={Heteronuclear-CEST imaging presents several unique properties when compared to
1H-CEST, which is based on water, including background-free signals, quantifyability and ability to monitor low concentrations of targets. Here we present the performance of the CEST approach in
19F-MRI framework for mapping multiple targets in a “multicolor” fashion. Specifically, the difference in binding kinetics between a
19F-agent and a molecular target (i.e., macrocyclic molecular host) and the different Δw values obtained in
19F-NMR lead to a clear
19F-CEST characteristics. The large
19F-CEST effect obtained and its Δw dependency allow the mapping of two molecular targets simultaneously using single
19F-probe.}
}
@inproceedings{ISMRM2018_3584,
annote={ISMRM2018_3584},
pages={3584},
file={ISMRM2018_3584.pdf:ISMRM2018_3584.pdf:PDF},
title={Calcium-dependent molecular f{MRI} using a magnetic nanosensor},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3584.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Benjamin B Bartelle and Satoshi Okada and Nan Li and Vincent Breton-Provencher and Mriganka Sur and Alan P Jasanoff},
abstract={Superparamagnetic iron oxide nanoparticles are a modular platform technology for sensors with sub nM sensitivity and robust biomedical applications. In this work we engineer nanoparticle sensors that display Ca
2+ dependent aggregation and demonstrate the first functional MRI study of Ca
2+ dynamics as well as the first in vivo demonstration of a dynamic nanosensor.}
}
@inproceedings{ISMRM2018_3585,
annote={ISMRM2018_3585},
pages={3585},
file={ISMRM2018_3585.pdf:ISMRM2018_3585.pdf:PDF},
title={Sensing intracellular calcium ions using a manganese-based {MRI} contrast agent},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3585.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Benjamin B Bartelle and Barandov Ali and Catherine G Williamson and Emily S Loucks and Alan P Jasanoff},
abstract={Inspired by the classical work of R. Tsien on cell-permeable calcium specific chelators using readily cleavable acetomethoxy esters (AM) of BAPTA and taking advantage of our own, novel, cell permeable manganese-based contrast agent, we developed a new MRI contrast that displays membrane permeability, cellular accumulation via cleavable ester groups and physiological sensitivity to calcium. With this breakthrough innovation, we present a series of firsts for functional molecular imaging, reporting chemically and optogenetically induced calcium transients with MRI in living cells.}
}
@inproceedings{ISMRM2018_3586,
annote={ISMRM2018_3586},
pages={3586},
file={ISMRM2018_3586.pdf:ISMRM2018_3586.pdf:PDF},
title={Labelling of collagen type I templates with a novel naturally derived contrast agent for magnetic resonance imaging in soft tissue engineering},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3586.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Heinz Peter Janke and Nihan Güvener and Weiqiang Dou and Jozef Cremers and Paul Borm and Wout Feitz and Arend Heerschap and Fabian Kiessling and Egbert Oosterwijk},
abstract={Contrast agents (CA) need to be applied for monitoring tissue-engineered implants by MR imaging. However, currently used CAs have limitations (i.e. negative contrast, label instability). In this study, Hemin-Lysine complex (HL) -as a naturally derived alternative CA- is used for active labeling of hybrid collagen-based templates. HL-labeled templates are clearly identified because of their bright signal in T1-weighted MR images. The signal of labeled templates and thus their integrity could be followed over time when subcutaneously implanted in a mouse model. Thus, loading collagen-based templates with HL appears to be a promising strategy to localize and monitor its fate upon implantation.}
}
@inproceedings{ISMRM2018_3587,
annote={ISMRM2018_3587},
pages={3587},
file={ISMRM2018_3587.pdf:ISMRM2018_3587.pdf:PDF},
title={The effect of liposomal encapsulation on the chemical exchange properties of diamagnetic {CEST} agents.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3587.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Eleni Demetriou and Harriet Story and Robin Bofinger and Helen Hailes and Alethea Tabor and Xavier Golay},
abstract={Liposome encapsulation of glucose or 2-deoxy-D-glucose (2-DG) may be exploited to enhance the CEST signal by reducing the overall apparent exchange rate. Here we aim to construct a complete theoretical model to measure the exchange properties of diamagnetic CEST agents. Experimentally measured exchange rates of glucose and 2-DG in the liposomal system were found to be reduced by one or two orders of magnitude due to the intermembrane exchange between the intra- and extra-liposomal compartment because of restrictions in water transfer imposed by the lipid membrane. These new theoretical and experimental findings are expected to benefit applications of diamagnetic liposomes to image biological processes.}
}
@inproceedings{ISMRM2018_3588,
annote={ISMRM2018_3588},
pages={3588},
file={ISMRM2018_3588.pdf:ISMRM2018_3588.pdf:PDF},
title={A mannan-based probe for multimodal imaging of cancer and immune cells},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3588.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Daniel Jirak and Andrea Galisova and Marketa Jiratova and Mariia Rabyk and Martin Hruby and Milan Hajek},
abstract={Presented mannan-based polymers have promising properties for tumor and metastasis imaging due to their biocompatibility, nanosize and specificity for the immune cells. In this study, two mannan-based polymers were tested by multimodal imaging (MRI and fluorescence). The polymers showed superior imaging properties compared to a commercially available contrast agent. FLI signal at the liver and higher signal at the injection site in the mouse with MN-Ox suggested slower elimination process due to addition of polyoxazoline chains in its structure. Both probes were visualized by MR and optical imaging modality at the injection sites and in the lymph nodes of the experimental mice suggesting their promising properties for cancer diagnosis.}
}
@inproceedings{ISMRM2018_3589,
annote={ISMRM2018_3589},
pages={3589},
file={ISMRM2018_3589.pdf:ISMRM2018_3589.pdf:PDF},
title={High Temporal Resolution Dynamic {BOLD} {MRI} in Tracking Kidney Response to Hypoxia and Hyperoxia in a Rat {AKI} model at 7T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3589.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Kaixuan Zhao and Yingjie Mei and Guixiang Yang and Yanqiu Feng},
abstract={Blood oxygenation level-dependent magnetic resonance imaging has shown potential to monitoring the tissue oxygenation. However, the absolute T2* value has shown limited usefulness to surrogate the renal microcirculation. This work we monitor the AKI rat renal response to hypoxia and hyperoxia to tracking the hemodynamic changes in the progress of acute kidney injury.}
}
@inproceedings{ISMRM2018_3590,
annote={ISMRM2018_3590},
pages={3590},
file={ISMRM2018_3590.pdf:ISMRM2018_3590.pdf:PDF},
title={A new class of pH-responsive para{CEST} agents for {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3590.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={James S Ratnakar and Sara Chirayil and Alexander M Funk and Zoltan Kovacs and A Dean Sherry},
abstract={Many paraCEST agents have reduced sensitivity in vivo due to the reduction of the T
2 relaxation of bulk water by T
2ex exchange. Phosphonate coordinating side-chains in cyclen-based complexes exclude inner sphere water and this should reduce the interfering T
2ex effects. In the new complexes reported here, a combination of phosphonate and hydroxypropyl pendant arms were incorporated to take advantage of the CEST signal from the Ln-bound OH. Protonation of the coordinating phosphonates results in a shift in the resonance frequency of Ln-bound OH CEST. These agents display several attractive features for imaging tissue pH in vivo by CEST MRI.}
}
@inproceedings{ISMRM2018_3591,
annote={ISMRM2018_3591},
pages={3591},
file={ISMRM2018_3591.pdf:ISMRM2018_3591.pdf:PDF},
title={Relaxation-compensated multi-pool {CEST} signal at 7T {MRI} of {WHO} {IV} gliomas is dependent on the anatomic localization},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3591.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Constantin Dreher and Johanna Oberhollenzer and Johannes Windschuh and Jan-Eric Meißner and Felix Sahm and Martin Bendszus and Andreas Unterberg and Wolfgang Wick and Peter Bachert and Mark E. Ladd and Heinz-Peter Schlemmer and Moritz Zaiss and Alexander Radbruch and Daniel Paech},
abstract={As patients with WHO IV° gliomas are still having a dismal prognosis, further tumor characterization is needed. With prognosis and histopathological parameters being dependent on tumor localization and Chemical-Exchange-Saturation-Transfer(CEST) MRI at 7T being one of the latest advances in tumor imaging, we have prospectively evaluated CEST signals in 21 patients. Amide CEST and ADC parameters are significantly different with regard to brain hemispheres and correlating. CEST NOE(Nuclear Overhauser-Effect) is not different with regard to brain hemispheres, but in case of contact to the subventricular zone, which is accompanied by worse prognosis. NOE is possibly showing complementary information to Amide CEST.}
}
@inproceedings{ISMRM2018_3592,
annote={ISMRM2018_3592},
pages={3592},
file={ISMRM2018_3592.pdf:ISMRM2018_3592.pdf:PDF},
title={Detecting prostatic zinc ({II}) loss in a {TRAMP} prostate cancer model by glucose-stimulated zinc ({II}) secretion in vivo with {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3592.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Veronica Clavijo Jordan and Alia Al-Ebraheem and Su-Tang Lo and Tina Geraki and Andre F. Martins and Sara Chirayil and Neil M. Rofsky and Michael Farquharson and A. Dean Sherry},
abstract={We have previously found that glucose stimulates the secretion of zinc stores from epithelial cells in the prostate gland and that this glucose-stimulated zinc secretion (GSZS) can be detected in vivo by a Gd-based zinc sensor with T
1-weighted MRI. Here we elucidate the mechanisms of enhancement in the healthy prostate and loss of enhancement in the malignant prostate by GSZS MRI and Synchrotron-Radiation X-Ray Fluorescence (SR-XRF). GSZS MRI detects the unique loss of zinc content in the lateral lobe of the malignant prostate as observed by SR-XRF with a Gd-based high affinity Zn
2+ sensor.}
}
@inproceedings{ISMRM2018_3593,
annote={ISMRM2018_3593},
pages={3593},
file={ISMRM2018_3593.pdf:ISMRM2018_3593.pdf:PDF},
title={{MR} and optical imaging study to evaluate effects on bioorthogonal click therapy in prostate cancer mouse models},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3593.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Sudath Hapuarachchige and Colin Huang and Jorge S Flores and Cyril Bařinka and Dmitri Artemov},
abstract={Click therapy is a new therapeutic strategy for cancers minimizing systemic toxicity and enhancing therapeutic efficacy. For this strategy, slow internalization of pretargeted cell surface receptors gives a sufficient window for clearance of the unbound pretargeting component before administration of delivery components. Here, we tested click therapy in PSMA(+) PC3-PIP and PSMA(-) PC3-Flu (control) tumors to evaluate delivery and internalization of components. We observed that internalization of 5D3 antibody is fast, which may interfere with the delivery of therapeutic components. In large tumors with leaky vasculature, 5D3 antibody can effectively extravasate leading to the cluster formation with delivery component in tumor microenvironment.}
}
@inproceedings{ISMRM2018_3594,
annote={ISMRM2018_3594},
pages={3594},
file={ISMRM2018_3594.pdf:ISMRM2018_3594.pdf:PDF},
title={Imaging glucose-stimulated zinc secretion from the prostate and pancreas using a Mn({II})-based zinc sensor},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3594.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Veronica Clavijo Jordan and Sara Chirayil and Andre F Martins and Namini Paranawithana and James S Ratnakar and A. Dean Sherry},
abstract={Imaging glucose-stimulated zinc secretion (GSZS) from secretory tissues has proven useful at assessing organ function and health; current probes to detect zinc secretion by MRI have so far been limited to gadolinium-based sensors. In this work we introduce a manganese-based zinc sensor and show that pancreatic and prostatic zinc detection is not compromised when using Mn instead of Gd for imaging GSZS in vivo. Biodistribution studies indicate that the Mn-based sensor is cleared intact after renal filtration but degraded during hepatobiliary clearance.}
}
@inproceedings{ISMRM2018_3595,
annote={ISMRM2018_3595},
pages={3595},
file={ISMRM2018_3595.pdf:ISMRM2018_3595.pdf:PDF},
title={In Vivo Murine Cardiac 19F {MRI} and Tracking of {PFCE}- and Fu{GENE}-labeled Progenitor Stem Cells in the C57{BL}/6 Mouse},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3595.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Chris Constantinides and Ricardo Carnicer Hijazo and Andrew Shaw and Jyoti Patel and Edyta Swider and Mangala Srinivas and Carolyn Carr},
abstract={Despite advances in the visualization of pre-labeled SCs with perfluorocarbon-ether-nanoparticles (PFCE-NPs) or other MRI contrast agents using 19F MRI, there have been no prior reports on murine cardiac 19F imaging of exogenously administered cardiac SCs following direct, intra-cardiac injections. To-this-date, human or murine in vivo cardiac studies have been limited, while prior reported imaging attempts in rats have been prohibitively lengthy, costly (use of multiple millions of cells/animal) and practically complex to reproduce in mice. We report herein significant enhancements of PFCE-NP label following labeling with the highly efficient agent FuGENE, thereby allowing in vivo murine cardiac 19F MRI visualization with minimal cellular toxicity.}
}
@inproceedings{ISMRM2018_3596,
annote={ISMRM2018_3596},
pages={3596},
file={ISMRM2018_3596.pdf:ISMRM2018_3596.pdf:PDF},
title={A Triple Modality Contrast Agent for Acoustic and Magnetic Particle Imaging ({MPI}) of Stem Cells},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3596.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jeanne Lemaster and Fang Chen and Taeho Kim and Jesse Jokerst},
abstract={Magnetic particle imaging is a novel and background-free imaging technique that offers good depth of penetration and high contrast of iron oxide nanoparticle tracers. Here, we combined MPI with acoustic imaging through multimodal polymeric nanoparticles. We used these nanoparticles for in vivo stem cell tracking.}
}
@inproceedings{ISMRM2018_3597,
annote={ISMRM2018_3597},
pages={3597},
file={ISMRM2018_3597.pdf:ISMRM2018_3597.pdf:PDF},
title={Translating 19F-based cellular {MRI} from 9.4T to 3T: Feasibility of future clinical applications},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3597.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ashley V Makela and Paula J Foster},
abstract={A limitation of
19F-based MRI is low sensitivity; consequently, many studies have been performed at high field strengths with relatively long scan times (ie. 30 minutes). Because of this, human applications have seemed unreasonable. Here, we investigate the feasibility of translating
19F MRI from 9.4T to a 3T clinical scanner. Upon optimization of 3T scan parameters,
19F image quality was similar and
19F spin quantification was not different to a scan performed at 9.4T. Additionally, a 30 second scan produced the same
19F spin quantification as a 30 minute scan at 3T. These findings show promise for future clinical applications.}
}
@inproceedings{ISMRM2018_3598,
annote={ISMRM2018_3598},
pages={3598},
file={ISMRM2018_3598.pdf:ISMRM2018_3598.pdf:PDF},
title={Magnetic Particle Imaging as a tool for cell tracking: filling the voids left by {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3598.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ashley V Makela and Jeffrey M Gaudet and Paula J Foster},
abstract={Magnetic Particle Imaging (MPI) is emerging as a specific, quantitative and sensitive cellular imaging technique. MPI directly detects a SPIO tracer as positive contrast and this signal is linearly quantifiable with zero tissue attenuation. Because of this, MPI is well suited for in vivo cell tracking to image tumor associated macrophages (TAMs). TAM content can be used as a biomarker to predict tumor growth and metastatic potential. Mice bearing 4T1 and 168FARN tumors were imaged post intravenous SPIO injection to investigate for the first time, the application of MRI and MPI to differentiate between murine cancer models with varying metastatic potentials.}
}
@inproceedings{ISMRM2018_3599,
annote={ISMRM2018_3599},
pages={3599},
file={ISMRM2018_3599.pdf:ISMRM2018_3599.pdf:PDF},
title={Novel tracking method for cellular patterns obtained by Laser-Assisted Bioprinting using Magnetic Resonance Imaging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3599.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Olivia Kérourédan and Sylvain Miraux and Raphael Devillard and Emeline J Ribot},
abstract={One major issue of in situ bioprinting is related to cell pattern imaging in vivo. Magnetic Resonance Imaging (MRI) associated with Micron-sized superparamagnetic Iron Oxide (MPIO) particles constitutes a non-invasive method for tracking cells in vivo. In this study, optimal MPIO concentrations for tracking bioprinted cells were determined. Cell densities of patterns and MRI signals were correlated. MRI was used to track cell patterns in vitro and post-mortem, after in situ bioprinting onto a mouse calvaria defect. Results indicate that MRI combined with MPIO cell labeling is a valuable technique to track bioprinted cells with sufficient precision.}
}
@inproceedings{ISMRM2018_3600,
annote={ISMRM2018_3600},
pages={3600},
file={ISMRM2018_3600.pdf:ISMRM2018_3600.pdf:PDF},
title={Cellular {MRI} reveals altered brain arrest of genetically-engineered reporter-expressing metastatic breast cancer cells},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3600.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Katie Parkins and Veronica Dubois and Suzy Wong and Amanda Hamilton and Paula Foster and John Ronald},
abstract={While BLI is very complementary to MRI in evaluating the fate of many different cell populations in vivo, including cancer cells, some considerations for the use of BLI have been reported including an increase in tumor growth variation as well as a change in metastatic pattern following luciferase tagging. The objective of this work was to use cellular and anatomical MRI to characterize the in vivo growth patterns of naive and lentiviral-engineered brain-seeking breast cancer cell lines co-expressing fluorescent and bioluminescent reporters in the mouse brain.
}
}
@inproceedings{ISMRM2018_3601,
annote={ISMRM2018_3601},
pages={3601},
file={ISMRM2018_3601.pdf:ISMRM2018_3601.pdf:PDF},
title={Disrupted topological organization of brain structural network associated with prior overt hepatic encephalopathy in cirrhotic patients},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3601.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Hua-Jun Chen},
abstract={Disrupted topological organization of brain structural network associated with prior overt hepatic encephalopathy}
}
@inproceedings{ISMRM2018_3602,
annote={ISMRM2018_3602},
pages={3602},
file={ISMRM2018_3602.pdf:ISMRM2018_3602.pdf:PDF},
title={Resting-State f{MRI} Low-Frequency Fluctuations in Temporal-Lobe Epilepsy Patients and The Relationship with Hemodynamic Correlates},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3602.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Chantelle Lim and Baxter P Rogers and Victoria L Morgan},
abstract={Amplitudeof low-frequency fluctuations (ALFF) of blood oxygenation is a marker of resting-state functional magnetic resonance imaging (fMRI) used to measure localspontaneous activity of the brain. However, interpretation of ALFF results is still unclear. Comparing ALFF values in left and right temporal-lobeepilepsy (TLE) patients with controls showed an increase in seizure-related regions. Increases in cerebral blood flow (CBF) were also found to be partially responsible for the increase in ALFF in another cohort of controls. Therefore, the development of ALFF measures may potentially provide a non- invasive perfusion measure in the presurgical evaluation of TLE.}
}
@inproceedings{ISMRM2018_3603,
annote={ISMRM2018_3603},
pages={3603},
file={ISMRM2018_3603.pdf:ISMRM2018_3603.pdf:PDF},
title={Effect of repetitive head trauma on diffusion {MRI} derived measures of diffusivity and free water},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3603.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Virendra R Mishra and Zhengshi Yang and Karthik Sreenivasan and Xiaowei Zhuang and Sarah Banks and Dietmar Cordes and Charles Bernick},
abstract={In this study, we utilized the diffusion MRI (dMRI) data of cognitively impaired and nonimpaired active professional fighters from the Professional Fighters Brain Health Study and studied the effect of repeated head trauma on conventional and advanced dMRIderived measures of diffusivity and free-water fraction (fiso). Our study revealed increased fiso and weighted FA in cognitively impaired active fighters, in addition to increased conventional radial and mean diffusivity, which was further associated with years of fighting in impaired fighters. Our study opens new avenues to explore advanced dMRImeasures to understand the effect of repetitive head trauma on cognition.}
}
@inproceedings{ISMRM2018_3604,
annote={ISMRM2018_3604},
pages={3604},
file={ISMRM2018_3604.pdf:ISMRM2018_3604.pdf:PDF},
title={Exploratory Group Independent Components Analysis of resting state f{MRI} data reveals widespread brain function impairments in Gulf War Illness},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3604.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Kaundinya Gopinath and Unal Sakoglu and Bruce Crosson and Robert Haley},
abstract={Around 200,000 veterans (up to 32\% of those deployed) of the 1991 Gulf War (GW) suffer from GW illness (GWI), which is characterized by multiple deficits in cognitive, emotion, sensory and interoception domains. In this study we examined 23 GWI patients and 30 age-matched controls with resting state fMRI (rsFMRI) in order to map impairments in brain function networks in GWI with group independent components analysis. The results show that GWI veterans exhibit impaired, or abnormally increased functional connectivity in a lot of brain function networks consistent with their self-reported symptoms.}
}
@inproceedings{ISMRM2018_3605,
annote={ISMRM2018_3605},
pages={3605},
file={ISMRM2018_3605.pdf:ISMRM2018_3605.pdf:PDF},
title={Measuring the effect of soman, a seizure-inducing chemical warfare nerve agent, with simultaneous perfusion and brain oxygenation measurements},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3605.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Kevin Lee and Sara Bohnert and Matthew Bouchard and Ying Wu and Cory Vair and John Mikler and Jeff F Dunn},
abstract={Chemical warfare nerve agents induce neurological damage through seizures. It is widely accepted in the field of nerve agent research that excitotoxicity is the main contributor to the neuropathology. Growing evidence suggests the involvement of hypoxia in seizure-related neuropathology. However, it is difficult to detect hypoxia without directly measuring oxygenation. We applied a method we developed to simultaneously quantify tissue oxygenation and cerebral blood flow to detect hypoxia following soman-induced seizures.}
}
@inproceedings{ISMRM2018_3606,
annote={ISMRM2018_3606},
pages={3606},
file={ISMRM2018_3606.pdf:ISMRM2018_3606.pdf:PDF},
title={High Resolution 3D T1-weighted Black Blood {MRI} of Human Lenticulostriate Arteries as Biomarker for Small Vessel Diseases},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3606.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Samantha J Ma and Lirong Yan and Lei Cao and Giuseppe Barisano and Marlene Casey and John Ringman and Meng Law and Arthur Toga and Danny JJ Wang},
abstract={The early microvascular changes related to cerebral small vessel disease are still unclear. In this study, we applied a T1-weighted turbo spin echo sequence with variable flip angles for high resolution black-blood MRI to delineate the lenticulostriate arteries (LSA) at 3T. The vessel delineation was rated using a 4-point scale and then correlated with clinical vascular risk factors as well as measures of executive function, cognitive flexibility and attention. LSA ratings were found to be reliable. Subjects with> 4 visible LSA that were minimally tortuous exhibited positive trends with executive function and male subjects tended to have poorer LSA delineation.}
}
@inproceedings{ISMRM2018_3607,
annote={ISMRM2018_3607},
pages={3607},
file={ISMRM2018_3607.pdf:ISMRM2018_3607.pdf:PDF},
title={Investigation of differences in the connectivity between the insular cortex and brain activity and metabolites between male smokers and non-smokers in their 20s},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3607.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Seung-Man Yu},
abstract={The purpose of the experiment was to investigate differences in the connectivity between the insular cortex out of the brain areas and other brain areas and the concentration of neuro-metabolites between male adult smokers and non-smokers in their 20s so that the results can be utilized as basic data for smoking cessation programs. The Cr concentration in the right insular cortex area of non-smokers is higher than that of smokers. In addition, it could be seen that smokers had stronger connectivity between their right insular cortex area and Gyrus Right, Occipital Fusiform and Gurus Right areas than non-smokers and that non-smokers had stronger connectivity between their left insular cortex area and the frontal role right than smokers.}
}
@inproceedings{ISMRM2018_3608,
annote={ISMRM2018_3608},
pages={3608},
file={ISMRM2018_3608.pdf:ISMRM2018_3608.pdf:PDF},
title={Iron accumulation in the striatonigral pathway of patients with Fabry Disease},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3608.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Camilla Russo and Giuseppe Pontillo and Antonio Pisani and Francesco Saccà and Eleonora Riccio and Antonio Macera and Giovanni Rusconi and Arnaldo Stanzione and Pasquale Borrelli and Vincenzo Brescia Morra and Enrico Tedeschi and Arturo Brunetti and Sirio Cocozza and Giuseppe Palma},
abstract={In Fabry Disease (FD) patients, compared to healthy controls, a significant increase in magnetic susceptibility has been observed in the substantia nigra and in the striatum, associated to a significant volume loss limited to the single substantia nigra. These findings probably reflect neurodegenerative phenomena due to pathological iron deposition in these particular extrapyramidal relay stations. This evidence supports the current hypothesis of a permeative cerebral involvement in FD that goes further the pure cerebrovascular association, thus shedding new light on this condition.}
}
@inproceedings{ISMRM2018_3609,
annote={ISMRM2018_3609},
pages={3609},
file={ISMRM2018_3609.pdf:ISMRM2018_3609.pdf:PDF},
title={Pre-operative {DTI} of white matter tracts in patients with idiopathic normal pressure hydrocephalus (i{NPH}) correlates with changes in clinical findings after shunt surgery},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3609.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Johanna Mårtensson and Katarina Laurell and Johan Virhammar and Elna-Marie Larsson},
abstract={Preoperative prediction of shunt surgery outcome is difficult. A test to predict outcome is missing. The use of diffusion tensor imaging (DTI) as a bioimaging marker was investigated. DTI parameters in white matter tracts were compared between patients and healthy controls and also correlated with changes in clinical findings after shunt surgery. Significantly differences between healthy controls and patients were found. Correlations were found between preoperative DTI results and changes in clinical findings after shunt surgery, suggesting DTI to be a supportive tool for prediction of clinical outcomes from shunt surgery in patients with idiopathic normal pressure hydrocephalus (iNPH).}
}
@inproceedings{ISMRM2018_3610,
annote={ISMRM2018_3610},
pages={3610},
file={ISMRM2018_3610.pdf:ISMRM2018_3610.pdf:PDF},
title={Abnormal Gray Matter Structural networks in Idiopathic Normal Pressure Hydrocephalus},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3610.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Lekang Yin and Yanmei Yang and Jianding Ye and Hong Yu},
abstract={Idiopathic normal pressure hydrocephalus (iNPH) is a neurological disorder, the structural networks changes were never studied. We examined changes in gray matter structural network of patients with iNPH comparing with normal elderly people. Global network modularity was significantly larger in the iNPH network compared with the NC network (P<0.05). Eight nodes with significantly decreased betweenness were found in right frontal, temporal, insula lobe and right posterior cingulate region of iNPH network, while only one node was detected with significantly larger betweenness. Hubs of the iNPH network were mostly located in temporal areas and limbic lobe, while hubs of NC network were mainly located in frontal areas. We found some abnormalities in gray matter structural network that may relate to the occurrence of iNPH.}
}
@inproceedings{ISMRM2018_3611,
annote={ISMRM2018_3611},
pages={3611},
file={ISMRM2018_3611.pdf:ISMRM2018_3611.pdf:PDF},
title={Structural and functional assessments of eye, brain and visual field in glaucoma using optical coherence tomography, magnetic resonance imaging and perimetry},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3611.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Vivek Trivedi and Yue Chen and Carlos Parra and Ahmel Arshad and Ji Won Bang and Mengfei Wu and Ian Conner and Kevin Chan},
abstract={We used 3-Tesla anatomical MRI, DTI, optical coherence tomography and perimetry to assess structural and functional changes in the eye and brain in glaucoma patients across disease stages. Both optic nerve and optic chiasm volumes were found to decrease from early to advanced staged glaucoma and were associated with inner retinal thinning and visual field functional loss. Fractional anisotropy, mean diffusivity and radial diffusivity in optic radiation were significantly different from early to advanced staged patients, but not when comparing control to early disease states. These results suggest anatomical MRI and DTI may be useful in monitoring glaucomatous brain damages non-invasively across stages.}
}
@inproceedings{ISMRM2018_3612,
annote={ISMRM2018_3612},
pages={3612},
file={ISMRM2018_3612.pdf:ISMRM2018_3612.pdf:PDF},
title={Dose-dependent effects of citicoline on the visuomotor response and white matter integrity in the visual pathway after chronic intraocular pressure elevation},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3612.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yolandi van der Merwe and William J Kohler and Michael Krawchuk and Xiaoling Yang and Leon C Ho and Yu Yu and Ying Chau and Christopher K Leung and Kevin C Chan},
abstract={Glaucoma is a neurodegenerative disease that can cause irreversible vision loss. Elevated intraocular pressure is a major risk factor for the glaucoma; however, the disease may still progress in some patients after lowering IOP. Citicoline has been suggested as a potential therapeutic to ameliorate damage caused by neurodegenerative diseases, including glaucoma, but its neuroprotective effects remain incompletely studied. In this study, we analyzed the dose-dependent effect of oral citicoline on visual behavior response and white matter integrity in a rodent model of glaucoma. The results show citicoline preserves visual behavior response and visual system integrity in a dose dependent manner.}
}
@inproceedings{ISMRM2018_3613,
annote={ISMRM2018_3613},
pages={3613},
file={ISMRM2018_3613.pdf:ISMRM2018_3613.pdf:PDF},
title={Microstructural and metabolism changes in the longitudinal progression of white matter hyperintensity},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3613.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yeerfan Jiaerken and Xiao Luo and Minming Zhang},
abstract={To evaluate the microstructural and metabolism property in the white matter that later become white matter hyperintensity (WMH) and the property of WMH that later disappeared. And we discovered that there is a dynamic change in microstructural and metabolism in WMH. Metabolism in NAWM will start to decline rapidly to a point where microstructure will then start to deteriorate.}
}
@inproceedings{ISMRM2018_3614,
annote={ISMRM2018_3614},
pages={3614},
file={ISMRM2018_3614.pdf:ISMRM2018_3614.pdf:PDF},
title={Neurological symptoms and pathology in patients with newly-diagnosed, “classical” coeliac disease},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3614.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Iain Croall and Marios Hadjivassiliou and Panagiotis Zis and David S Sanders and Pascale Aeschlimann and Richard A Grünewald and Paul Armitage and Dan Connolly and Daniel Aeschlimann and Nigel Hoggard},
abstract={Coeliac disease is known to cause neurological problems, although these are not well recognised by healthcare professionals. In this prospective study of 100 newly-diagnosed patients with classical coeliac disease, we show 67\% to have neurological symptoms and 46\% to have abnormal NAA/Cr values by MR Spectroscopy investigation. Further, we demonstrate how participants with positivity to transglutaminase 6, an auto-antibody suggested to be involved in neuro-pathology of gluten-related disorders, are more likely to suffer these. Finally, we present a volumetric analysis showing subcortical atrophy in this sub-group. This study highlights the prevalence and potential mechanisms, of neurological involvement in coeliac disease.}
}
@inproceedings{ISMRM2018_3615,
annote={ISMRM2018_3615},
pages={3615},
file={ISMRM2018_3615.pdf:ISMRM2018_3615.pdf:PDF},
title={Paravermal sign: new {MR} imaging features of cerebellum in neuronal intranuclear inclusion disease},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3615.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Noriko Sato and Atsuhiko Sugiyama and Yukio Kimura and Yuko Saito and Hiroshi Matsuda},
abstract={Neuronal intranuclear inclusion disease (NIID) is a neurodegenerative disorder with characteristic high signals along the corticomedullary junction on MR DWI. However, cerebellar findings have not been fully evaluated on MRI and we reviewed them in a series of ten NIID patients. MRI results showed cerebellar atrophy (10/10), high intensity signal on FLAIR images in medial part of the cerebellar hemisphere immediately beside the vermis (paravermal area) (7/10) and in the middle cerebellar peduncle (6/10). The paravermal abnormal signals could be a clue for diagnosis of NIID even in the past MR studies in which DWI was not examined.}
}
@inproceedings{ISMRM2018_3616,
annote={ISMRM2018_3616},
pages={3616},
file={ISMRM2018_3616.pdf:ISMRM2018_3616.pdf:PDF},
title={Regional cortical folding morphometry in Friedreich ataxia using Laplace Beltrami based gyrification index},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3616.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Rosita Shishegar and Imis Dogan and Martin B. Delatycki and Gary F. Egan and Elsdon Storey and Louise A. Corben and Nellie Georgiou-Karistianis},
abstract={Friedreich ataxia (FRDA) is an inherited neurodegenerative disorder mainly affecting the spinal cord and dentate nuclei of the cerebellum. Although there is growing evidence of cerebral atrophy and cortical thinning in FRDA, no research has investigated the pattern of cortical folding (gyrification) in the disorder. We have proposed a new MRI analysis technique, Laplace Beltrami based gyrification index (LB-GI) and validated its use in individuals with FRDA. Preliminary results reveal significantly increased regional gyrification in the motor cortex in individuals with FRDA, compared to healthy controls. Overall, our results demonstrate that LB-GI is a sensitive technique which requires further investigation as a potential neuroimaging marker of disease progression in FRDA.}
}
@inproceedings{ISMRM2018_3617,
annote={ISMRM2018_3617},
pages={3617},
file={ISMRM2018_3617.pdf:ISMRM2018_3617.pdf:PDF},
title={Multi-delay Simultaneous-Multi-Slice p{CASL} Imaging of Acute Treatment Effects of Ketamine in Major Depression},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3617.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Kai Wang and Xingfeng Shao and Katherine Narr and Amber Leaver and Randall Espinoza and Danny Wang},
abstract={Sub-anesthetic dose of ketamine elicit acute and robust antidepressant effects, however the mechanism is still less understood. With a state-of-the-art Simultaneous Multislice EPI pCASL sequence, whole-brain rCBF and Arterial Transit Time (ATT) maps were acquired pre and post intravenous infusion of ketamine. Eight clusters were detected with significant CBF change, two of which (one in left inferior frontal gyrus, the other in right parietal lobe) were significantly correlated ( r=-0.7, p=0.04; r=-0.74, p=0.03 respectively) with Hamilton Depression rating score. This study suggests that possible mechanism of the antidepressant effects of ketamine is to increase CBF of certain mood- and attention-related brain regions.}
}
@inproceedings{ISMRM2018_3618,
annote={ISMRM2018_3618},
pages={3618},
file={ISMRM2018_3618.pdf:ISMRM2018_3618.pdf:PDF},
title={Impaired microstructural integrity of the callosum forceps minor in type 2 diabetes mellitus affect bilateral frontal functional connectivity},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3618.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Xin Wang and Zhou Zhang and Jiaming Lu and Xin Zhang and Zhao Qin and Yan Bi and Bing Zhang},
abstract={Type 2 diabetes mellitus (T2DM) is a risk factor for cognitive impairment. While its mechanism remains to be explored. In this study, using Automating Fiber-Tract Quantification (AFQ) analysis, we found that the fractional anisotropy (FA) in callosum forceps minor decreased in patients with T2DM, which indicated transverse white matter tracts connecting bilateral frontal cortex, was damaged. Meanwhile, functional connectivity between multiple brain regions within bilateral frontal cortex was decreased. The changes in the tract of callosum forceps minor might be the microstructural basis for functional changes of frontal cortex and help us understand the mechanism of T2DM related cognition decline.}
}
@inproceedings{ISMRM2018_3619,
annote={ISMRM2018_3619},
pages={3619},
file={ISMRM2018_3619.pdf:ISMRM2018_3619.pdf:PDF},
title={Quantitative Magnetic Resonance Imaging in diabetes: inflammation, oedema and neurodegeneration},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3619.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ana-Maria Oros-Peusquens and Ricardo Loucao and Elene Iordanishvili and Melissa Schall and Markus Zimmermann and Svenja Caspers and N. Jon Shah},
abstract={Type II diabetes is one of the most important metabolic disorders for public health with around 8\% prevalence in European population (11\% in the US). We report here for the first time a generalized increase in brain water content of ~ 2\% in type II diabetics compared to age- and gender-matched controls, supporting the presence of neuroinflammation in diabetes. Several other quantitative measures are investigated (T1, T2*, MT parameters, magnetic susceptibility and diffusion kurtosis) as well as region-based volume, area and cortical thickness. Regions with significant changes in a large number of quantitative parameters are identified.}
}
@inproceedings{ISMRM2018_3620,
annote={ISMRM2018_3620},
pages={3620},
file={ISMRM2018_3620.pdf:ISMRM2018_3620.pdf:PDF},
title={Perfusion Pattern Scores Associates with Disease Severity in Type 2 Diabetes},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3620.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yuheng Chen and Wenna Duan and Parshant Sehrawat and Vaibhav Chauhan and Freddy J Alfaro and Anna Gavrieli and Vera Novak and Weiying Dai},
abstract={Type 2 diabetes mellitus (T2DM) is associated with alterations in the blood brain barrier, neuronal damage and arterial stiffness, thus affecting cerebral metabolism and brain perfusion. We develop a machine learning method to investigate T2DM-related covariance pattern and its association with cognitive performance/disease severity. Our pipeline is superior to the traditional method and the pattern-related individual scores are associated to diabetes severity variables, mobility and cognitive performance at baseline. Besides, the longitudinal score change is associated with change of HbA1c and baseline cholesterol, indicating that this score is a promising biomarker for tracing the disease progression of individual T2DM patients.}
}
@inproceedings{ISMRM2018_3621,
annote={ISMRM2018_3621},
pages={3621},
file={ISMRM2018_3621.pdf:ISMRM2018_3621.pdf:PDF},
title={Distinct mechanism underlying patients who might benefit from edaravone or those may not - a combined quantitative susceptibility mapping and {DTI} study},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3621.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Qiuli Zhang and Haining Li and Ming Zhang and Dandan Zheng and Lijun Bai},
abstract={The coexistence of multiple complicated pathological mechanisms and lack of valid biomarker for treatment effects, remains to be main challenges that retarded ALS clinical trials. The approve of edaravone in treating ALS confirmed the importance of oxidative stress in ALS pathology. However, only a subgroup of patients would benefit with edaravone. We used QSM and DTI to explore the different mechanism that underlying those two cohorts. Our study revealed that neuroinflammation-prominent pathology and age-dependent oxidative stress might a feature for patients benefit with eradavone. While for patients not fulfill edaravone therapy, iron-mediated injury, like ferroptosis might accelerate disease progression.}
}
@inproceedings{ISMRM2018_3622,
annote={ISMRM2018_3622},
pages={3622},
file={ISMRM2018_3622.pdf:ISMRM2018_3622.pdf:PDF},
title={Structural analysis of m.3243A>G patients using 3D anatomical {MRI} brain scans},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3622.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Catherine Hossain and Julie Hall and Yi Ng and Alexandra Bright and Andrew Blamire and Douglass Turnbull and Robert McFarland and Grainne Gorman},
abstract={Symptoms associated with mitochondrial disease are heterogeneous and unpredictable. 17 m.3243A>G patients and 24 controls had 3D anatomical MRI brain scans, which were analysed to test the hypothesis that there are structural differences in patients that may potentially be used as biomarkers to predict symptoms. Results indicate head size is a possible surrogate biomarker for susceptibility to seizure-mediated strokes, but more detailed analysis did not provide any specific markers. Thinning of the cortex in the temporal poles appears to be directly related to the presence of the m.3243A>G point mutation and is an area to investigate further.}
}
@inproceedings{ISMRM2018_3623,
annote={ISMRM2018_3623},
pages={3623},
file={ISMRM2018_3623.pdf:ISMRM2018_3623.pdf:PDF},
title={{CORRELATION} {OF} {IMMUNE} {ACTIVATION} {BIOMARKERS} {AND} {MRS} {MEASURES} {IN} {ACUTE} {HIV} {INFECTION}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3623.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Napapon Sailasuta and Michelle L. D’Antoni and Philip Chan and Thep Chalermchai and Pasiri Sithinamsuwan and Somporn Tipsuk and Suteeraporn Pinyakorn and Bonnie Slike and Shelly Krebs and Vedbar Khadka and Eugene Kroon and Robert Paul and Serena Spudich and Victor Valcour and Jintanat Ananworanich and Lishomwa Ndhlovu},
abstract={Proton MRS was performed in 51 acute HIV participants. We observed Inverse correlations between sCD163 and markers of neuronal integrity (BG and PCG NAA) in select brain regions suggests regional variability to neuronal injury in AHI. Further, correlations between CSF sCD163 and BG Cho and mI reveal that membrane turnover activity and gliaactivation that occur early in infection remain susceptible to CNS neuroinflammation. Our observation suggests select brain injury linked to myeloid activation persists even early ART in AHI arguing for additional interventions to halt detrimental neuroinflammation.}
}
@inproceedings{ISMRM2018_3624,
annote={ISMRM2018_3624},
pages={3624},
file={ISMRM2018_3624.pdf:ISMRM2018_3624.pdf:PDF},
title={Whole-brain {MRSI} for Quantification of Metabolite Markers of Inflammation and Neuronal Integrity in {HIV}-1 Clade C Infection},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3624.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Varan Govind and Sameer Vyas and Vivek Gupta and Aman Sharma and Sulaiman Sheriff and Mahendra Kumar and Niranjan Khandelwal},
abstract={HIV-1 enters the brain early in the course of infection and its replication continues despite use of combination anti-retrovirals (cART), causing chronic neuroinflammation, resulting in mild-to-moderate HIV-associated neurocognitive disorders in up to 50\% of infected individuals. HIV-1 virus can be found throughout the brain of infected individuals, however, its maximum viral loads were found in the basal ganglia, frontal and medial temporal lobes and hippocampus.
1 We evaluated the use of a whole-brain proton MR spectroscopic imaging (MRSI) method at 3Tesla to better characterize the metabolite changes within the whole brain as a result of HIV infection.
}
}
@inproceedings{ISMRM2018_3625,
annote={ISMRM2018_3625},
pages={3625},
file={ISMRM2018_3625.pdf:ISMRM2018_3625.pdf:PDF},
title={Overlap of R2* map based {SN} and {SN}pc defined by neuromelanin-sensitive {MRI} in Parkinson’s Disease: A promising diagnostic biomarker},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3625.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Naying He and Jason Langley and Shengdi Chen and Chunlei Liu and Yong Zhang and Fuhua Yan and Xiaoping Hu},
abstract={There is an urgent need for developing diagnostic imaging biomarkers for Parkinson’s Disease (PD). In this work, we applied a standardized substantia nigra pars compacta (SNpc) mask based on neuromelanin-sensitive MR images from healthy subjects to investigate the diagnostic performance of the SNpc overlap percentage and R2* in the SNpc overlap in PD. R2* in the SNpc overlap volume was increased in PD patients as compared to controls. Furthermore, it was significantly positively correlated with the disease duration in PD. We found an excellent diagnostic accuracy for the SNpc overlap percentage (AUC, 0.927) in PD.}
}
@inproceedings{ISMRM2018_3626,
annote={ISMRM2018_3626},
pages={3626},
file={ISMRM2018_3626.pdf:ISMRM2018_3626.pdf:PDF},
title={Visualization of Substantia Nigra Pars Compacta: {MPRAGE} vs. {DANTE} T1-{SPACE}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3626.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Sonoko Oshima and Yasutaka Fushimi and Tomohisa Okada and Takuya Hinoda and Takayuki Yamamoto and Hikaru Fukutomi and Yusuke Yokota and Akira Yamamoto and Tsutomu Okada and John Grinstead and Sinyeob Ahn and Kaori Togashi},
abstract={Neuromelanin-sensitive magnetic resonance techniques have been developed for depicting neuromelanin-rich structures such as substantia nigra pars compacta (SNpc). We compared visualization of SNpc between magnetization-prepared rapid gradient-echo imaging (MPRAGE) and delay alternating with nutation for tailored excitation-prepared T1-weighted variable flip angle turbo spin echo (DANTE T1-SPACE) in 21 healthy volunteers. DANTE T1-SPACE provided much better delineation of SNpc and showed higher signal intensity than MPRAGE. DANTE T1-SPACE can be used for evaluating SNpc.}
}
@inproceedings{ISMRM2018_3627,
annote={ISMRM2018_3627},
pages={3627},
file={ISMRM2018_3627.pdf:ISMRM2018_3627.pdf:PDF},
title={Automated White Matter Lesion Quantification Correlates With Gait and Cognitive Dysfunction In Parkinson’s Disease},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3627.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Eric Fang* and Mário João Fartaria* and Chu-Ning Ann and Bénédicte Maréchal and Tobias Kober and Jie-Xin Lim and Celeste Chen and Soo-Lee Lim and Julian Gan and Eng-King Tan and Ling-Ling Chan},
abstract={White matter lesions (WMLs) have an impact on neuronal connectivity; and consequently affect balance, mobility and cognition in both normal aging and disease states. Using a fully automated segmentation algorithm and multi-modal images, we estimated WMLs volumes to predict the clinical severity in a cohort of Parkinson’s disease (PD) patients and healthy controls (HC). Increased WMLs volume is strongly associated with both motor/gait and cognitive dysfunctions in PD. Lobar WMLs are found to have differential impact on distinctive cognitive domains. Automated volumetric quantification of WMLs load, particularly within the frontal and prefrontal regions can predict severity of symptoms in PD.}
}
@inproceedings{ISMRM2018_3628,
annote={ISMRM2018_3628},
pages={3628},
file={ISMRM2018_3628.pdf:ISMRM2018_3628.pdf:PDF},
title={White Matter Alterations in Parkinson’s Disease Analyzed with Combined Diffusion Magnetic Resonance Imaging and Magnetization Transfer Saturation Imaging: A Tract-Based Spatial Statistics Analysis},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3628.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Christina Andica and Koji Kamagata and Taku Hatano and Asami Saito and Yuki Takenaka and Akifumi Hagiwara and Masaaki Hori and Ryusuke Irie and Akihiko Wada and Kanako Kumamaru and Nobutaka Hattori and Shigeki Aoki},
abstract={Our study combined three in-vivo imaging modalities (diffusion tensor imaging, neurite orientation dispersion and density imaging and magnetization transfer saturation imaging) to provide a deeper understanding of white matter (WM) pathologies in Parkinson`s disease (PD). The tract-based spatial statistics analysis showed significantly decreased fractional anisotropy and intracellular volume fraction and increased mean diffusivity, axial diffusivity and radial diffusivity in an extensive area of WM in PD patients. Meanwhile, non-significantly increased myelin volume fraction was observed in limited areas of WM. The findings of this study might indicate that PD predominantly affects axons rather than myelin in WM.}
}
@inproceedings{ISMRM2018_3629,
annote={ISMRM2018_3629},
pages={3629},
file={ISMRM2018_3629.pdf:ISMRM2018_3629.pdf:PDF},
title={Brain Structural Differences in Healthy {LRRK}2 G2019S Mutation Carriers: An {MR} Radiomics Study},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3629.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Moran Artzi and Avner Thaler and Avi Orr Urterger and Talma Hendler and Nir Giladi and Anat Mirelman and Dafna Ben Bashat},
abstract={Structural brain differences in healthy LRRK2-G2019s mutation carriers who are at risk of developing Parkinson's disease (PD) were studied using radiomics analysis of DTI and T1-weighted images. 83 subjects were included: 43 healthy-carriers (HC) and 40 healthy-non-carriers (HNC). 18 statistical parameters were extracted for each modality in 14 subcortical brain regions. Various machine-learning classifiers were tested. The best classification results were obtained using RUSBoosted classifier, with average accuracy 73\%, sensitivity 68\% and specificity 79\%. Radiomics analysis revealed brain differences in HC in comparison to HNC. These results together with the preliminary results among converters support the hypothesis of utilization of structural compensatory mechanisms in this "at risk" cohort.}
}
@inproceedings{ISMRM2018_3630,
annote={ISMRM2018_3630},
pages={3630},
file={ISMRM2018_3630.pdf:ISMRM2018_3630.pdf:PDF},
title={Contribution of basal forebrain damage to cognitive deficits in Parkinson’s disease},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3630.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Fatma Gargouri and Cécile Gallea and Marie Mongin and Nadya Pyatigorskaya and Romain Valabregue and Marie Sarazin and Lydia Yahia-Cherif and Marie Vidailhet and Stéphane Lehéricy},
abstract={We investigated the contribution of basal forebrain damage in the cognitive dysfunction of 52 non-demented patients with Parkinson’s disease (PD) and 25 age-matched healthy controls using diffusion and resting state functional MRI. Patients showed diffusion changes in the basal forebrain and the fornix. They also showed reduced functional connectivity between the septal area and the temporal lobe including the hippocampi and parahippocampal gyri and between the basal nucleus of Meynert and frontal areas and bilateral thalami. Structural and functional changes correlated with memory and executive functions.}
}
@inproceedings{ISMRM2018_3631,
annote={ISMRM2018_3631},
pages={3631},
file={ISMRM2018_3631.pdf:ISMRM2018_3631.pdf:PDF},
title={Automatic analysis of multi-echo {GRE} and {DTI} data of Parkinson’s disease patients and control subjects using atlas-based subcortical regions},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3631.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Gerd Melkus and Santanu Chakraborty and Goncalo Santos and Donghoon Kim and David Grimes and Tiago Mestre},
abstract={Multi-parametric brain MRI longitudinal studies, which result in multiple quantitative parameter maps, can require intense post-processing work and time if several sub-cortical structures need to be analyzed individually on a region of interest (ROI) basis. In this study, we used a brain co-registration process together with a structural subcortical probability atlas for an automated analysis of quantitative MRI data. Patients with a recent diagnosis of Parkinson’s disease (<1 year) and healthy controls underwent brain MRI in a longitudinal study design. Quantitative maps derived from multi-echo GRE and DTI acquisitions were analyzed using this automated post-processing procedure at 3 different time points.}
}
@inproceedings{ISMRM2018_3632,
annote={ISMRM2018_3632},
pages={3632},
file={ISMRM2018_3632.pdf:ISMRM2018_3632.pdf:PDF},
title={Clinical diagnosis based on speech mechanics with dynamic (real time) {MRI}, functional {MRI} and acoustics of speech (spectrogram)},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3632.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Sunita Gudwani and S. Senthil Kumaran and Madhuri Behari},
abstract={In evidence based clinical practice, mapping speech production problems is a challenge, further with cognitive impairment in degenerative disease makes the examination and assessments difficult. Visualization of the flexible vocal tract (dynamic MRI), cognitive planning (BOLD activation) and automated acoustic analysis (spectrogram) of speech production in motor degenerative diseases (like Parkinson’s Disease) might reframe the diagnostic evaluations. Empirically dynamic MRI is important technique for articulatory movements when adjunct with cognitive planning (fMRI) and spectrogram analysis may team as sensitive measures in clinical diagnosis. Thus this pilot study was planned to observe the significance.}
}
@inproceedings{ISMRM2018_3633,
annote={ISMRM2018_3633},
pages={3633},
file={ISMRM2018_3633.pdf:ISMRM2018_3633.pdf:PDF},
title={White Matter Differences in Parkinson’s Disease: a 7Tesla Tract-Based Spatial Statistics Study},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3633.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Remi Patriat and Jacob Jacob Niederer and Sommer Amundsen Huffmaster and Matthew Petrucci and Noam Harel and Colum MacKinnon and Christophe Lenglet},
abstract={We used tract-based spatial statistics (TBBS) of 7Tesla fractional anisotropy (FA) measures to find differences between a cohort of early PD patients (N=30) and healthy controls (N=28). We examined the evolution of these differences by adding a PD cohort with longer disease duration (N=21). TBSS analysis revealed increased FA in the early PD group in the portions of the superior longitudinal fasciculus and the corticospinal tracts near M1, pre-motor and SMA. Subsequent analyses revealed increased FA in both PD groups compared to the control group. Radial diffusivity was significantly lower in the early and late PD groups compared to controls.}
}
@inproceedings{ISMRM2018_3634,
annote={ISMRM2018_3634},
pages={3634},
file={ISMRM2018_3634.pdf:ISMRM2018_3634.pdf:PDF},
title={Investigating differences in laterality and novel diffusion-derived metrics between freezing of gait ({FOG}) and non-{FOG} early Parkinson’s disease patients},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3634.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Virendra R Mishra and Zhengshi Yang and Karthik Sreenivasan and Xiaowei Zhuang and Dietmar Cordes and Brent Bluett},
abstract={In this study, we utilized the diffusion MRI (dMRI) data of self-reported freezing of gait early Parkinson’s disease (PD-FOG) patients and PD-nonFOG patients from the Parkinson’s Progressive Markers Initiative (PPMI) database and investigated laterality along with the sensitivity of the conventional and advanced dMRIderived measures to classify the two groups. Our study revealed an asymmetric left laterality in early PD-FOG and a significant association of weighted fractional anisotropy with UPDRS scores in PD-FOG patients. Our study opens a window to understand disease severity using a potential new imaging biomarker for PD-FOG.}
}
@inproceedings{ISMRM2018_3635,
annote={ISMRM2018_3635},
pages={3635},
file={ISMRM2018_3635.pdf:ISMRM2018_3635.pdf:PDF},
title={Concurrent assessment of perfusion and functional connectivity in Parkinson’s disease},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3635.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Maria Marcella Lagana and Laura Pelizzari and Niels Bergsland and Alice Pirastru and Giuseppe Baselli and Mario Clerici and Pietro Cecconi and Raffaello Nemni and Francesca Baglio},
abstract={We aimed to assess if resting state functional connectivity (FC) changes were related to hypoperfusion in a group of Parkinson’s disease (PD) patients. Independent component analysis was performed to identify common spatial patterns of FC and of arterial spin labeling perfusion separately, in the whole group of PD and healthy controls. Concurrent FC and perfusion group differences were assessed. The observed FC alteration in the visual network may be influenced by the significantly reduced cerebral blood flow in the lateral occipital cortex and vice-versa. The cross-talk between functional and perfusion findings should be considered when interpreting the results.}
}
@inproceedings{ISMRM2018_3636,
annote={ISMRM2018_3636},
pages={3636},
file={ISMRM2018_3636.pdf:ISMRM2018_3636.pdf:PDF},
title={Alteration of brain structure network in Parkinson’s disease with and without rapid eye movement sleep behavior disorder},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3636.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Tao Guo and Xiaojun Guan and Qiaoling Zeng and Min Xuan and Quanquan Gu and Xiaojun Xu and Minming Zhang},
abstract={We detected the alteration of structure correlation network in Parkinson’s disease (PD) patients with and without Rapid eye movement sleep behavior disorder (RBD). 191 PD patients including 51 possible RBD (pRBD) and 140 non-possible RBD (npRBD) and 76 normal controls were included. Structure brain networks were constructed by thresholding gray matter volume correlation matrices and analyzed using graph theoretical approaches. Significant enhanced nodal properties and hub recruitment were found mainly in limbic system while decreased nodal parameters were observed in cerebellum in PD-pRBD. This study may contribute to understand the pathophysiology of PD-RBD.}
}
@inproceedings{ISMRM2018_3637,
annote={ISMRM2018_3637},
pages={3637},
file={ISMRM2018_3637.pdf:ISMRM2018_3637.pdf:PDF},
title={White Matter Property of the Reward Circuits in Impulse Control Disorders in Parkinson’s Disease},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3637.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ru-Jen Lin and Weng-Ming Liu and Yung-Chin Hsu and Yu-Chen Wei and Pin-Yu Chen and Joshua O Goh and Wen-Yih Tseng and Ruey-Meei Wu},
abstract={Approximately 10-20\% of Parkinson’s disease (PD) patients treated with dopamine agonist may develop impulse control disorder (ICD). We aimed to investigate microstructural characteristics of the white matter (WM) tracts in the reward circuits in PD-ICD by DSI images. ReMAP (Mean Apparent Propagator) was used for DSI reconstruction and TBAA (tract-based automatic analysis) for further tract analysis. Among the frontostriatal tracts (FS) and amygdala-related tracts, we found largerAD and/or RD in FS_motor cortex and amygdala-related tracts in ICD subjects, which may indicate a less healthy WM microstructure and may further underlie the vulnerability to dopamine stimulation and result in hyper-gambling behavior.}
}
@inproceedings{ISMRM2018_3638,
annote={ISMRM2018_3638},
pages={3638},
file={ISMRM2018_3638.pdf:ISMRM2018_3638.pdf:PDF},
title={Differential diagnosis in Parkinsonism using diffusion tensor as measured from multiple cortical regions},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3638.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Fan Huang and Sung-han Lin and Chin-Song Lu and Yi-Hsin Weng and Yao-Liang Chen and Shu-Hang Ng and Yi-Ming Wu and Chih-Chien Tsai and Yi-peng Liu and Jiun-Jie Wang},
abstract={Parkinsonism is a long-term degenerative disorder of the central nervous system that mainly affects the motor system. The cortical parcellation algorithm was applied to evaluate the cortical involvement in the patients with PD by using diffusion tensor image. The fractional anisotropy is feasible in the brain of patients with Parkinsonism. Therefore fractional anisotropy could be a potential image based biomarker for monitoring Parkinson progression.}
}
@inproceedings{ISMRM2018_3639,
annote={ISMRM2018_3639},
pages={3639},
file={ISMRM2018_3639.pdf:ISMRM2018_3639.pdf:PDF},
title={Motor compensation in Parkinson’s disease ({PD}): a multimodal neuroimaging study},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3639.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Nicolas Villain and Stéphane Lehéricy and Nadya Pyatigorskaya and Romain Valabrègue and Sara Fernandez-Vidal and Rahul Gaurav and Olivier Jaubert and Marie-Odile Habert and Graziella Mangone and Jean-Christophe Corvol and Marie Vidailhet and David Grabli},
abstract={Motor compensation mechanisms in PD rely on very distinct levels of evidence and have never been assessed altogether. They were tested among 68 early PD patients who underwent dopaminergic imaging and MRI (T1 neuromelanin, fMRI, DTI). We created an adjusted motor severity index (ratio between akinetic motor severity and neuromelanin substantia nigra alteration) and performed correlations between this index and the hypothesized compensation mechanisms. As a result, new dopaminergic synapses or more active dopaminergic synapses, reorganization of motor and cognitive subcortical loops and of the associative areas of the cerebellum are the main motor compensation mechanisms in early PD.}
}
@inproceedings{ISMRM2018_3640,
annote={ISMRM2018_3640},
pages={3640},
file={ISMRM2018_3640.pdf:ISMRM2018_3640.pdf:PDF},
title={The roles of sensorimotor and default mode-memory retrieval networks in staging {PD} cognitive decline},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3640.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Meng-Hsiang Chen and Weiyan Yin and Wei-Che Lin and Weili Lin},
abstract={In addition to motor disability, the development of cognitive decline is one of the most notorious symptoms in Parkinson’s disease (PD). Yet, a biomarker capable of accurately diagnosing cognitive impairments in PD patients remains elusive. Our results, based on resting-state functional MRI, suggested that functional connectivity in sensorimotor together with default mode-memory retrieval networks may serve a promising biomarker either for staging cognitive decline or neuropsychiatric scores.}
}
@inproceedings{ISMRM2018_3641,
annote={ISMRM2018_3641},
pages={3641},
file={ISMRM2018_3641.pdf:ISMRM2018_3641.pdf:PDF},
title={Cerebellum and Sensory Motor Resting State Network Behaviors in tremor- and akinetic rigid -predominant patients with Parkinson’s disease},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3641.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jiaming Lu and Prasanna Karunanayaka and Eunyoung Lee and Qing Yang and Mechelle Lewis and Paul Eslinger and Xuemei Huang},
abstract={The striatal dopamine depletion in Parkinson's disease (PD) explains clinical symptoms such as bradykinesia and rigidity, but not resting tremor thought to be associated with cerebellothalamic (CTC) circuit dysfunction. In this study we used resting state fMRI to investigate differences in the CTC network in akinetic-rigid (PD
AR) and tremor predominant (PD
T) PD patients with closely matched demographic and cognitive variables. The results support a type dependent functional disruption in the cerebellum and SMA rs-networks in PD patients with otherwise comparable disease severity, neurocognitive performance and overall brain morphology.}
}
@inproceedings{ISMRM2018_3642,
annote={ISMRM2018_3642},
pages={3642},
file={ISMRM2018_3642.pdf:ISMRM2018_3642.pdf:PDF},
title={Neuromelanin sensitive {MRI} features of substantia nigra and locus coeruleus in de novo Parkinson’s disease and its phenotypes},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3642.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Lirong Jin and Jian Wang and Yuanfang Li and Zhen Huang and Yong Zhang and Kai Liu and Mengsu Zeng},
abstract={This current study provides in vivo evidence that width and high signal were significantly decreased in SNc and LC of de novo PD patients using NM-MRI, compared with controls. We also observed that the neuromelanin changes in substantia nigra were across both motor phenotypic expressions and non-motor (with vs. without depressive symptoms) subtypes, while LC neuron reduction is more notable in PD with depressive symptoms. Our finding implies that the NM-MR imaging have potential applications to improve the clinical diagnosis and detect the heterogeneityof PD.}
}
@inproceedings{ISMRM2018_3643,
annote={ISMRM2018_3643},
pages={3643},
file={ISMRM2018_3643.pdf:ISMRM2018_3643.pdf:PDF},
title={Deep Learning on Anatomical Brain {MRI} to Classify Motor Dysfunction in Parkinson's Disease},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3643.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yu-Hsueh Wu and Yasi Jiang and Yu-Chun Lo and Yumei Yue and Ting Shen and Fu-Shan Jaw and You-Yin Chen* and Baorong Zhang* and Hsin-Yi Lai*},
abstract={We introduced an innovative two-staged deep artificial neural network (DNN) model focusing on diagnostic prediction of Parkinson’s disease (PD) using T1-weighted images, given a training set consisting of cortical thickness, surface area, grey matter volume and corresponding clinical scales, our proposed model was trained to classify the PD with different motor symptoms and performed the diagnostic prediction on basis of generated clinical scales. Results showed our DNN classifier and generator reached the averaged accuracy of 100\% and 97.9\%, respectively. To our knowledge, our technique was the first to tackle the classification of motor dysfunction in PD from anatomical brain MRI.}
}
@inproceedings{ISMRM2018_3644,
annote={ISMRM2018_3644},
pages={3644},
file={ISMRM2018_3644.pdf:ISMRM2018_3644.pdf:PDF},
title={
1H-[
13C]-{NMR} Evaluation of Neurometabolism in Rotenone Mouse Model of Parkinson’s disease},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3644.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Anant Bahadur Patel and Shoumik Roy and Varadarajan S Komanduri},
abstract={Parkinson’s disease (PD) is a common progressive neurodegenerative disorder, which affects motor coordination and movement. Currently there is no biomarker for the early diagnosis of disease. In the current study we have evaluated the neurometabolism in rotenone mouse model of PD using
1H-[
13C]-NMR NMR spectroscopy in conjunction with an infusion of [1,6-
13C
2]glucose. Our results show that the neurometabolism is compromised in rotenone treated mice suggesting that both the excitatory and inhibitory neurotransmission are impaired in PD.}
}
@inproceedings{ISMRM2018_3645,
annote={ISMRM2018_3645},
pages={3645},
file={ISMRM2018_3645.pdf:ISMRM2018_3645.pdf:PDF},
title={Non-invasive Characterization of the Cerebellar Nuclei in Degenerative Cerebellar Ataxias ({SCA}3, {SCA}6) with Quantitative Susceptibility Mapping ({QSM}) at 3 Tesla},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3645.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Andreas Deistung and Dominik Jäschke and Sophia L Göricke and Dae-In Chang and Katharina M Steiner and Andreas Thieme and Jens Claaßen and Ellen Uslar and Markus Gerwig and Mark E Ladd and Jürgen R Reichenbach and Dagmar Timmann},
abstract={We investigated non-invasively the cerebellar nuclei of spinocerebellar ataxia type 3 (SCA3) and SCA6 patients by using quantitative susceptibility mapping (QSM) at 3 T. Absolute volumes, relative volumes (with respect to the total intracranial volume) and magnetic susceptibilities of the cerebellar nuclei were found to be significantly lower for the dentate between SCA6 patients and healthy controls but did not significantly differ between SCA3 and healthy controls. Univariate linear correlations of relative nuclei volumes with ataxia rating scales revealed statistically significant correlations for the dentate and globose nuclei in SCA6 but not in SCA3.}
}
@inproceedings{ISMRM2018_3646,
annote={ISMRM2018_3646},
pages={3646},
file={ISMRM2018_3646.pdf:ISMRM2018_3646.pdf:PDF},
title={Multi-modal multi-centre {MRI} study of rare spinocerebellar ataxia, type 14},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3646.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Farida Grinberg and Ezequiel Farrher and Peter Pieperhoff and Elena Schlapakow and Vincent Gras and Tanja Schmitz-Hübsch and Silke Lux and Ute Kopp and Hanna Gärtner and Eylem Kirlangic and Dagmar Timmann and Matthis Synofzik and Peter Bauer and Friedemann Paul and Matthias Endres and Thomas Klockgether and N. Jon Shah and Katrin Amunts and Sarah Doss and Martina Minnerop},
abstract={Diffusion MRI studies reveal significant white matter degeneration in cerebellar and cerebral regions of spinocerebellar ataxia patients, however, only common pathology types have been included. Here, we present the first combined deformation-based morphometry (to depict regions of volume loss) and diffusion tensor/kurtosis imagingstudy to analyse microstructural changes in the largest reported sample of rare spinocerebellar ataxia, type 14, enrolled in a coordinated multi-centre study. Beyond expected strong changes observed for all metrics in cerebellar regions, axial diffusion kurtosis exhibited additional extracerebellaralterations in compliance with observed extracerebellarsymptoms. Our results also suggest that patients might develop compensatory mechanisms.}
}
@inproceedings{ISMRM2018_3647,
annote={ISMRM2018_3647},
pages={3647},
file={ISMRM2018_3647.pdf:ISMRM2018_3647.pdf:PDF},
title={Phase Sensitive Inversion Recovery ({PSIR}) spinal cord imaging as a potential biomarker for Motor Neuron Disease},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3647.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Antje Bischof and Nicholas T. Olney and Howard J. Rosen and Eduardo Caverzasi and William A. Stern and Catherine Lomen-Hoerth and Bruce L. Miller and Roland G. Henry and Nico Papinutto},
abstract={With this study we investigated whether spinal cord gray and white matter atrophy could be detected in vivo in patients with a diagnosis within the motor neuron disease spectrum using PSIR imaging. Gray and white matter were successfully delineated in ten patients. Gray and white matter atrophy was detected in the majority of patients even if the lower or upper motor neuron was clinically unaffected. Patients with predominantly bulbar symptoms did not show relevant spinal cord abnormalities. This suggests a possible role of PSIR imaging as a biomarker for the spatial and temporal distribution of pathological changes in motor neuron disease.}
}
@inproceedings{ISMRM2018_3648,
annote={ISMRM2018_3648},
pages={3648},
file={ISMRM2018_3648.pdf:ISMRM2018_3648.pdf:PDF},
title={Intracortical T1-weighted/T2-weighted ratio signal changes in Huntington’s Disease},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3648.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Christopher D Rowley and Sarah J Tabrizi and Blair R Leavitt and Raymund A.C. Roos and Alexandra Durr and Nicholas A Bock},
abstract={Huntington’s disease (HD) is a genetic neurodegenerative disorder that is characterized by motor and cognitive dysfunction. Previous imaging studies have shown cortical thickness is reduced in HD and here we investigated potential changes in cortical tissue composition in Huntington’s based on previously acquired T
1-weighted (T1W) and T
2-weighted (T2W) images. We analyzed T
1W/T
2W ratios formed using images collected in 321 subjects from the TRACK-HD dataset representing various stages of HD and healthy controls. Intracortical T
1W/T
2W signal analysis revealed significant changes in the most advanced HD group. This may reflect HD related increases in myelin and/or iron in the cortex or a change in cytoarchitecture.
}
}
@inproceedings{ISMRM2018_3649,
annote={ISMRM2018_3649},
pages={3649},
file={ISMRM2018_3649.pdf:ISMRM2018_3649.pdf:PDF},
title={Genome-wide association studies of brain structure and function from {UK} Biobank data},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3649.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Gwenaelle Douaud and Lloyd Elliott and Kevin Sharp and Fidel Alfaro-Almagro and Sinan Shi and Karla Miller and Jonathan Marchini* and Steve Smith*},
abstract={The genetic basis of brain structure and function is largely unknown. We carried out genome-wide association studies of 3,144 distinct brain imaging derived phenotypes in UK Biobank. Notable significant associations include: iron-related genes linked to T2* in subcortical regions; extracellular matrix associated with white matter microstructure and lesion volume; genes regulating midline axon guidance related to pontine crossing tract organisation. More broadly, effects were mainly seen in imaging measures associated with genes involved in brain development and transport of nutrients. Genes implicated in neurodegenerative disorders were largely related to iron and cardiovascular traits and to brain development for psychiatric disorders.}
}
@inproceedings{ISMRM2018_3650,
annote={ISMRM2018_3650},
pages={3650},
file={ISMRM2018_3650.pdf:ISMRM2018_3650.pdf:PDF},
title={The Protective Effects of Ultramicronized Palmitoylethanolamide on the glutamatergic system in a triple transgene mouse model of Alzheimer disease},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3650.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Rossella Canese and Giulia Carpinelli and Gianmauro Palombelli and Maria Rosaria Brunzuoli and Silvio Calcagnini and Luca Steardo and Tommaso Cassano and Caterina Scuderi},
abstract={We investigate the effects of a chronic treatment with an endogenous lipid mediator palmitoylethanolamide on the onset and progression of AD in 3xTg-AD mice. Behavioural tests showed improvements in learning and memory and in both the depressive and anhedonia-like phenotype in PEA-treated 3×Tg-AD mice. MRI/MRS in vivo analysis, microdialysis and western blot, RT-PCR and immunofluorescence show that PEA normalizes astrocytic function, rebalances glutamatergic transmission and restrains neuroinflammation. The efficacy of PEA is particularly potent in younger mice, suggesting its potential as an early treatment.}
}
@inproceedings{ISMRM2018_3651,
annote={ISMRM2018_3651},
pages={3651},
file={ISMRM2018_3651.pdf:ISMRM2018_3651.pdf:PDF},
title={Relationship between brain and gut in autism spectrum disorder using diffusion {MRI} and intestinal bacteria gene analysis},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3651.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ting-Chun Lin and Ssu-Ju Li and Ching-Wen Chang and Hui-Ching Lin and Yin-Chieh Liu and Han-Fang Wu and Ming-Chia Chu and You-Yin Chen and Yu-Chun Lo},
abstract={Brain-behavior-gut-microbiome interaction, a bidirectional communication, was proposed as an important role in autism spectrum disorders (ASD). However, the correlation among gut microbiota, behavioral performance and brain microstructure in ASD are remained unclear. We chose a VPA-exposed rat model which performed autistic behaviors to investigate their brain-behavior-gut interaction. Diffusion MRI, behavioral tests and intestinal bacteria gene analysis were applied in this study. The findings implied that the altered brain microstructure and atypical distribution of the gut microbiota associate with the severity of the autistic behavior in ASD compared to the control group.}
}
@inproceedings{ISMRM2018_3652,
annote={ISMRM2018_3652},
pages={3652},
file={ISMRM2018_3652.pdf:ISMRM2018_3652.pdf:PDF},
title={Rapamycin treatment increases cerebral blood flow and attenuates anxiety in pre-symptomatic {APOE}4 mice: effects of sex and {APP} transgene},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3652.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ishita Parikh and David Ma and Jared D. Hoffman and Amy Wang and Ai-Ling Lin},
abstract={APOE4 is the strongest genetic risk factor for Alzheimer’s disease (AD). Pre-symptomatic APOE4 carriers have developed neurovascular deficits decades before amyloid beta (Aβ) aggregation. Here we show that with Rapamycin treatment for 16 weeks, pre-symptomatic APOE4 mice had restored cerebral blood flow (CBF) and attenuated anxiety, compared to those of APOE3 mice. The CBF restorations were particularly significant in female mice or those with APP transgene. As Rapamycin and MRI and are readily to be used in humans, the findings may provide valuable information for future clinical trials to prevent AD for APOE4 carriers.}
}
@inproceedings{ISMRM2018_3653,
annote={ISMRM2018_3653},
pages={3653},
file={ISMRM2018_3653.pdf:ISMRM2018_3653.pdf:PDF},
title={Genetic influence on Brain Microstructure and Cognitive Function and Change in an Ageing Cohort},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3653.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Kiyana Zarnani and Jayachandra Raghava and Naja Hansen and Erik Mortensen and Merete Osler and Martin Lauritzen and Egill Rostrup},
abstract={The notion that the brain’s early-life retains hints to its end is an evolving avenue explored by basic and clinical researchers alike. Implementing neuroimaging, genetics and neuropsychological tests, our focus is to unravel the complex process of brain ageing through characterisation of normal brain development in a longitudinal ageing cohort. This approach has the power to unveil robust candidate determinants responsible for the vulnerability of the ageing brain to late-life pathology. We demonstrate statistically significant correlations between common genetic variants, white-matter integrity and cognitive ability and change, highlighting biological risk-factors as mediators of differential trajectories of ageing.}
}
@inproceedings{ISMRM2018_3654,
annote={ISMRM2018_3654},
pages={3654},
file={ISMRM2018_3654.pdf:ISMRM2018_3654.pdf:PDF},
title={Differences in Metabolite Concentration and f{MRI} Activation in Subjects with Low and High Genetic Risk During Face-Name Paired-Associates Encoding and Retrieval Task in Healthy Adults},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3654.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={H Zhang and PW Chiu and SWH Wong and T Liu and GHY Wong and Q Chan and HKF Mak},
abstract={APOE-ε4 is an important genetic risk factor of early onset of AD. To investigate the possible differences in metabolite concentration and fMRI activation in subjects with high risk of developing AD (APOE-ɛ4 positive) compared to those with low risk, we employed Face-Name Paired-Associates (FN-PA) Encoding and Retrieval Task and evaluated the absolute concentrations of Glx in bilateral hippocampi and whole brain BOLD signal changes. Significant metabolic and activation differences were observed in the left hippocampus of pre-symptomatic subjects with high genetic risk of developing AD compared to subjects with low risk.}
}
@inproceedings{ISMRM2018_3655,
annote={ISMRM2018_3655},
pages={3655},
file={ISMRM2018_3655.pdf:ISMRM2018_3655.pdf:PDF},
title={Deep learning convolutional neural networks accurately classify genetic mutations and survival in gliomas},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3655.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Peter Chang and Melissa Khy and Yang Zhang and Min-Ying Su and Daniel Chow},
abstract={Gliomas represents a heterogeneous group of tumors with variable response to therapy despite sharing overlapping morphologic features. These differing outcomes partly relates to the multiple genetic mutations. For example, mutations in isocitrate dehydrogenase (IDH1) demonstrate significantly better survival compared to their wild counterparts
1,2. Therefore, an obstacle in glioma imaging analysis is that radiographic interpretation fails to account for the tumoral genetic variance, making it difficult to integrate clinically relevant biological activities. The primary objective of this abstract is to use a convolutional neural network (CNN) approach to discover specific imaging patterns predictive of the underlying genetic alterations of gliomas.}
}
@inproceedings{ISMRM2018_3656,
annote={ISMRM2018_3656},
pages={3656},
file={ISMRM2018_3656.pdf:ISMRM2018_3656.pdf:PDF},
title={Mapping the functional and anatomical signatures of chemogenetically modulated neurons in the salience network.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3656.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Joanes Grandjean and Francesca Mandino and Ling Yun Yeow and Teoh Chai Lean and Chris Jun Hui Ho and Amalina B. E. Attia and Lai Guan Ng and Malini Olivo and Fu Yu and Akhila Balachander},
abstract={BOLD functional magnetic resonance imaging (fMRI) provides crucial information about the large-scale organisation and function of the healthy and diseased brain. Despite its widespread use, identifying the neuronal-basis for specific functional imaging-based signatures, identified in human disorders and animal models, remains a mostly unmet challenge. Presently, we combine chemogenetic neuromodulation with whole-brain resting-state mouse fMRI and tissue clearing, to reveal both the functional contribution and spatial localization of a targeted neuronal population on resting-state functional connectivity. This approach enables researchers to examine the functional role played by selected neuronal populations on distributed neuronal networks.}
}
@inproceedings{ISMRM2018_3657,
annote={ISMRM2018_3657},
pages={3657},
file={ISMRM2018_3657.pdf:ISMRM2018_3657.pdf:PDF},
title={Clinico-genetic-anatomical comparisons of paroxysmal kinesigenic dyskinesia with and without {PRRT}2 mutations},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3657.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Lei Li and Xueling Suo and Qiyong Gong},
abstract={Paroxysmal kinesigenic dyskinesia (PKD) is a rare movement disorder characterized by sudden, brief attacks of involuntary movements. This study aims to detect the topological organization of white matter structural connectivity in PKD with and without PRRT2 mutations using graph theoretical approaches. Compared with non-PRRT2 mutation carriers, PRRT2 mutations carriers are significantly associated with a younger age of onset, a complicated form of PKD, combined phenotypes of dystonia and chorea and a tendency for a family history of PKD in our population, as well as showed topological trends for randomization.}
}
@inproceedings{ISMRM2018_3658,
annote={ISMRM2018_3658},
pages={3658},
file={ISMRM2018_3658.pdf:ISMRM2018_3658.pdf:PDF},
title={Neuroimaging based biomarkers for detecting craving and predicting relapse in methamphetamine dependence},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3658.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Chang Qi and Xiaobing Fan and Sean Foxley and Yanhui Liao and Qiuxia Wu and Jingsong Tang and Wei Hao and Tieqiao Liu},
abstract={This study investigates whether insula cortex abnormalities of methamphetamine-dependent subjects (MADs) can detect craving state and predict relapse susceptibility. Voxel based morphometry and statistical parametric mapping were used on structural MRI of MADs. Total 142 MADs were divided into two groups: model-group (n=112) and validation-group (n=30) from follow-up MADs. The results showed that MADs without craving had significantly smaller insula volume. Optimal insula volume determined from Youden index cut-off point on ROC analysis could be used as MRI bio-markers with acceptable accuracy for detecting craving state. Our results could help guide optimally timed intervention, prevention and treatment strategies for MADs.}
}
@inproceedings{ISMRM2018_3659,
annote={ISMRM2018_3659},
pages={3659},
file={ISMRM2018_3659.pdf:ISMRM2018_3659.pdf:PDF},
title={Epileptogenesis Imaging biomarker identification in the Mesial Temporal lobe epilepsy ({MTLE}) mouse model},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3659.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yvan Dietrich and Gabriel Dieuset and Mélanie Lagarrigue and Hervé Saint-Jalmes and Benoit Martin and Charles Pineau and Fabrice Wendling and Pierre-Antoine Eliat},
abstract={This work presents preliminary promising results on Mesial temporal lobe epilepsy (MTLE) mouse model suggesting that MRI/MRS-based biomarkers could be of great interest to detect early changes in the lesioned brain and to characterize epileptogenesis after traumatic brain injury.}
}
@inproceedings{ISMRM2018_3660,
annote={ISMRM2018_3660},
pages={3660},
file={ISMRM2018_3660.pdf:ISMRM2018_3660.pdf:PDF},
title={Quantifying acrolein with {MRS}: a viable biomarker to assess location and severity of {TBI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3660.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Nicole Vike and Jonathan Tang and Riyi Shi and Joseph Rispoli},
abstract={Currently, only invasive methods exist to study the molecular effects of traumatic brain injury (TBI). By instead using magnetic resonance spectroscopy (MRS), a non-invasive, quantitative method can be used to safely assess the severity and location of injury. Acrolein, a biomarker of TBI, increases in rat brain tissue following TBI. Acrolein shows signature peaks downfield of water at 6.5 and 9.4 ppm. We have successfully measured whole-brain phantom-injected acrolein using Bruker 7T MRS sequences and determined T
1 for acrolein, using NMR, so MRS parameters can be adjusted to maximize acrolein signal. Quantifying acrolein with MRS could provide a viable method to assess injury location and severity.}
}
@inproceedings{ISMRM2018_3661,
annote={ISMRM2018_3661},
pages={3661},
file={ISMRM2018_3661.pdf:ISMRM2018_3661.pdf:PDF},
title={{BIO}markers of {DEP}ression ({BIODEP}) study: Raised peripheral inflammation associated with changes in striatal microstructure},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3661.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Charlotte L Clarke and Manfred G Kitzbichler and Gareth J Barker and Marta M Correia and Nick G Dowell and Samuel A Hurley and John Mclean and Tobias Wood and NIMA Consortium and Mara Cercignani and Ed T Bullmore and Neil A Harrison},
abstract={Inflammation is implicated in the aetiology of major depressive disorder (MDD) and is known to affect brain microstructure: e.g. the striatum as found with neurite orientation dispersion and density imaging (NODDI) and quantitative magnetization transfer (qMT) imaging. Further, individuals with high inflammation (C-reactive protein (CRP)>3mg) respond less well to antidepressants. The BIOmarkers of DEPression (BIODEP) multi-centre study is aiming to characterise the inflamed MDD phenotype. We report across-site data harmonization and interim results demonstrating a negative correlation between the water fraction content (NODDI) and CRP within the ventral striatum. Multi-modal imaging results (qMT, multi-component relaxometry) across the full cohort will be reported.}
}
@inproceedings{ISMRM2018_3662,
annote={ISMRM2018_3662},
pages={3662},
file={ISMRM2018_3662.pdf:ISMRM2018_3662.pdf:PDF},
title={A survey of best practice guidelines to harmonize neuroimaging biomarkers for neurodegenerative diseases},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3662.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jorge Jovicich and Frederik Barkhof and Claudio Babiloni and Karl Herholz and Christoph Mullert and Bart N.M. van Berckel and Giovanni B Frisoni and SRA-NED JPND Working Group},
abstract={
Current challenges in neurodegenerative diseases (ND): need for early and accurate markers for differential diagnosis, prognosis, progression tracking and intervention assessments.
Big-data neuroimaging studies might help addressing these challenges. However, large-sample neuroimaging data still lacks standardization (multi-vendor acquisition, analysis) and cross –validation (across markers, across large populations), in particular with state-of-the-art MRI hardware (≥32 head RF channel coils and powerful gradients).
Here we: i) evaluate current barriers perceived by the broad neuroimaging research/clinical/industry communities for the large-scale harmonization of MRI/PET-SPECT/EEG neuroimaging methods in the context of ND studies and ii) propose actions that may help addressing these barriers.}
}
@inproceedings{ISMRM2018_3663,
annote={ISMRM2018_3663},
pages={3663},
file={ISMRM2018_3663.pdf:ISMRM2018_3663.pdf:PDF},
title={Development of an {MR}-based Biomarker of Arteriolar Sclerosis},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3663.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Nazanin Makkinejad and Arnold M. Evia and Ashish Tamhane and Chantal Sopacua and Sue E. Leurgans and Julie A. Schneider and David A. Bennett and Konstantinos Arfanakis},
abstract={Arteriolar sclerosis is often present in the brain of older adults and has been associated with lower cognitive performance and higher risk of dementia. There is currently no standard biomarker for arteriolar sclerosis. Future clinical trials of therapeutic interventions targeting arteriolar sclerosis will require an approach for participant selection with high positive predictive value (PPV). The purpose of this work was to develop a classifier with high PPV for arteriolar sclerosis based on information about regional white matter hyperintensities, magnetic susceptibility, cerebral microbleeds and demographics.}
}
@inproceedings{ISMRM2018_3664,
annote={ISMRM2018_3664},
pages={3664},
file={ISMRM2018_3664.pdf:ISMRM2018_3664.pdf:PDF},
title={Parameters From Dynamic Contrast-Enhanced Magnetic Resonance Imaging Are Biomarkers Predicting Response after Radiotherapy to Brain Metastases},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3664.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Zhuo Shi and Lizhi Xie and Peng Wang and XinMing Zhao and Han Ou-Yang},
abstract={Dynamic contrast-enhanced (DCE) MRI provides additional information regarding blood-brain barrier integrity and Ktrans is directly proportional to the level of permeability of the blood-brain barrier. In our study, we found demonstrates that SRS of cerebral metastasis is associated with a reduction of Ktrans values in the early post-treatment period. DCE-MRI derived parameters of may be a promising imaging biomarker of tumor aggressiveness.}
}
@inproceedings{ISMRM2018_3665,
annote={ISMRM2018_3665},
pages={3665},
file={ISMRM2018_3665.pdf:ISMRM2018_3665.pdf:PDF},
title={23Na-{MRI} demonstrates a sodium gradient within gliomas as a biomarker of tumor heterogeneity},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3665.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Fulvio Zaccagna and Frank Riemer and Mary A McLean and James T. Grist and Joshua Kaggie and Rolf Schulte and Sarah Hilborne and Tomasz Matys and Jonathan H. Gillard and Colin Watts and Stephen J. Price and Martin J. Graves and Ferdia A. Gallagher},
abstract={Glioma grade and the extent of local infiltration are important for guiding management. Imaging tumor heterogeneity may improve diagnosis and therapy planning. 23Na-MRI has been used here to demonstrate a gradient in sodium concentration across gliomas: necrosis > viable tissue > edema. This gradient was evident in all the tumors analyzed and is consistent with the expected underlying cellular microstructure where the sodium concentration is dominated by the extracellular fluid in edema and by an absence of cells in the necrotic core. The study provides evidence that 23Na-MRI represents an imaging biomarker of tumor heterogeneity and tissue microstructure in glioma.}
}
@inproceedings{ISMRM2018_3666,
annote={ISMRM2018_3666},
pages={3666},
file={ISMRM2018_3666.pdf:ISMRM2018_3666.pdf:PDF},
title={Is occipital bending a structural biomarker of risk for depression and sensitivity to treatment?},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3666.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Karen Fullard and Jerome Maller and Thomas Welton and Matthew Lyon and Fraser Callaghan and Leanne Williams and Mayuresh Korgaonkar and A. John Rush and Evian Gordon and Stephen Koslow and Stuart Grieve},
abstract={Occipital Bending (OB) was investigated as an MRI imaging biomarker for major depressive disorder (MDD) using data from large, well characterized, international, randomised study recruiting non-geriatric adult participants (iSPOT-D, n=68 control, 231 MDD). The presence of OB and the angle of occipital bending (OBA) was correlated with a repeated battery of neuropsychiatric assessments and response to 6 weeks of antidepressant treatment. A greater proportion of rightward bending was present in MDD in comparison to control individuals. Underlying association between OB and MDD is likely.}
}
@inproceedings{ISMRM2018_3667,
annote={ISMRM2018_3667},
pages={3667},
file={ISMRM2018_3667.pdf:ISMRM2018_3667.pdf:PDF},
title={Multivariate {MR} Biomarkers Predict Cognitive Decline in Mouse Models of Alzheimer’s Disease},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3667.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Alexandra Badea and Robert J Anderson and Russell Dibb and Yi Qi and Natalie A Delpratt and Hongjiang Wei and Chunlei Liu and William C Wetsel and Brian B Avants and Carol A Colton},
abstract={We propose a multivariate approach for characterizing mouse models of Alzheimer’s disease (AD), which integrates imaging and behavior in a joint analysis. We used manganese enhanced MRI (MEMRI) to identify brain areas associated with reduced performance in a spatial memory task. We quantified genotype differences based on morphometry, T1 weighted (T1W) signal and quantitative susceptibility maps (QSM). We find that the integration of multiple imaging biomarkers is a better predictor of cognitive decline, relative to using single biomarkers in isolation.}
}
@inproceedings{ISMRM2018_3668,
annote={ISMRM2018_3668},
pages={3668},
file={ISMRM2018_3668.pdf:ISMRM2018_3668.pdf:PDF},
title={Is {MRI} all we need? Prediction of conversion between normal cognitive function, mild cognitive impairment and Alzheimer’s disease},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3668.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Shiyang Chen and Ke Qi and Deqiang Qiu},
abstract={. In this study, we aimed to use machine learning methods to establish the quantitative value of MRI alone in the prediction of changes between disease states such as from normal cognitive function (NC) to mild cognitive impairment (MCI) and MCI to AD and compare with the combined predictive power of MRI, PET, neuropsychological evaluations and CSF analysis. Very high overall accuracy can be achieved using both RF and DNN methods. Interestingly, predictive power of MRI features is very close to all features combined, suggesting MRI might contain much of the information provided by neuropsychological evaluations, PET scans among others combined. The methodology adopted in this study also provides a framework for evaluating the value of different imaging techniques in a quantitative manner.}
}
@inproceedings{ISMRM2018_3669,
annote={ISMRM2018_3669},
pages={3669},
file={ISMRM2018_3669.pdf:ISMRM2018_3669.pdf:PDF},
title={Rapid and robust high-resolution mapping of proton pool size ratio in spinal cord after injury in squirrel monkeys},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3669.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Feng Wang and Tung-Lin Wu and Ke Li and Li Min Chen and John C. Gore},
abstract={High-resolution quantitative magnetization transfer (qMT) MRI provides a noninvasive means to detect and characterize myelination before and after neural injury and during repair. This study aims to systematically evaluate the accuracy and precision of pool size ratio (PSR) measurements using either 5-, 2- or 1-parameter modeling for assessing injury-associated changes in spinal cords in squirrel monkeys in order to optimize a rapid, sensitive and high-resolution PSR mapping protocol for applications in primates at high field. In addition, the sensitivity of PSR to demyelination in the dorsal pathway rostral and caudal to an injury site has been evaluated.}
}
@inproceedings{ISMRM2018_3670,
annote={ISMRM2018_3670},
pages={3670},
file={ISMRM2018_3670.pdf:ISMRM2018_3670.pdf:PDF},
title={Time makes the difference: Comparison of {ADC} values obtained with {OGSE} and {PGSE} sequences for differentiation of human head and neck tumors},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3670.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Mami Iima and Akira Yamamoto and Ichiro Tateya and Morimasa Kitamura and Thorsten Feiweier and Koichi Omori and Kaori Togashi},
abstract={The correlation of ADC values with different diffusion times, as obtained from OGSE and PGSE, was investigated in patients with head and neck tumors. A significant decrease of ADC values in head and neck cancers was noted with the increase of diffusion time (p < .0.05). Care needs to be taken when interpreting OGSE-ADC and PGSE-ADC values, as flow effects will contribute to these values, which was suspected in light of the (artefactual) increase of ADC values using PGSE compared to OGSE.}
}
@inproceedings{ISMRM2018_3671,
annote={ISMRM2018_3671},
pages={3671},
file={ISMRM2018_3671.pdf:ISMRM2018_3671.pdf:PDF},
title={Improving classifications of brain tumor tissue with Sparse Dictionary Learning based analysis of dynamic susceptibility contrast enhanced {MRI} data},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3671.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Silun Wang and Shu Zhang and Liya Wang and Bing Ji and Tianming Liu and Hui Mao},
abstract={We analyzed the DSC MRI signals based on patterns of descriptive DSE-MR parameters by using Sparse Dictionary Learning (SDL) coding method. We successfully decomposed DSC MRI signals into linear combinations of multiple components based on sparse representation of DSC MRI signals in the tumor region of tumor core and peritumoral edema which might be represent multiple heterogeneity component in brain tumors. Assessment of diagnostic performance of SVM classification after cross validation revealed that the combination of conventional DSC temporal characteristics and dictionary learning based DSC temporal features would result in the best classification accuracy between tumor core and peritumoral edema (with total diagnostic accuracy of 77\%, AUC 0.78).}
}
@inproceedings{ISMRM2018_3672,
annote={ISMRM2018_3672},
pages={3672},
file={ISMRM2018_3672.pdf:ISMRM2018_3672.pdf:PDF},
title={The effects of {LIS}1 deletion in the adult mouse brain and partial rescue by LiCl: A T2 mapping, magnetization transfer and diffusion {MRI} study},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3672.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Hagit Dafni and Liraz Kaidar and Inbal E Biton and Aditya Kshirsagar and Orly Reiner},
abstract={LIS1, a gene mutated in lissencephaly (“smooth brain”) have been investigated mainly in the developing brain. Initial studies demonstrated distinct ataxia and rapid lethality following Lis1 conditional deletion in adult mice. Therefore, our aim was to investigate the postnatal roles of LIS1 and the underlying mechanism. Conditional Lis1 knockout mice studied by MRI pre and 5 days post, tamoxifen-induced Lis1 deletion, showed increase in T2 and ADC and decrease MTR and FA0, in the lateral ventricles and in brain regions related to motion and auditory functions. These alterations and changes in the Wnt pathway were partially rescued by LiCl treatment.
}
}
@inproceedings{ISMRM2018_3673,
annote={ISMRM2018_3673},
pages={3673},
file={ISMRM2018_3673.pdf:ISMRM2018_3673.pdf:PDF},
title={Stability of silica coating of magnetic nanoparticles for cell tracking},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3673.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Vít Herynek and Lenka Kubíčková and Ondřej Kaman and Pavel Veverka and Milan Hájek},
abstract={Magnetic nanoparticles are broadly used for cell tracking in vivo using magnetic resonance imaging. Silica coating, often used for magnetic nanoparticles, represents an inert and stable barrier between the nanoparticle core and cell environment. However, the coating may disintegrate at high temperatures and expose the core. We monitored this process using dynamic relaxometry and confirmed substantial extend of dissolution by transmission electron microscopy. The process probably reflected the equilibrium of solid silica and soluble silicic species in highly dilute suspensions at higher temperature.}
}
@inproceedings{ISMRM2018_3674,
annote={ISMRM2018_3674},
pages={3674},
file={ISMRM2018_3674.pdf:ISMRM2018_3674.pdf:PDF},
title={Optimized Fluorine-19 {MRI} Quantification and Characterization of Inflammation in Atherosclerotic Plaques in Mice at 3T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3674.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Emeline Darçot and Roberto Colotti and Jérôme Yerly and Maxime Pellegrin and Anne Wilson and Stefanie Siegert and Matthias Stuber and Ruud B. van Heeswijk},
abstract={Establishing a direct quantification and monitoring of inflammation in diseases such as atherosclerosis in a clinical setting is one of the main goals of fluorine-19 (
19F) MRI of perfluorocarbons (PFCs). To this end, with
19F imaging and a denoising algorithm, we demonstrated the feasibility of quantitative
19F MRI in small inflammation sites such as atherosclerotic plaques in mice at 3T (average PFCs concentration per plaque=0.49±0.10mM; average plaque volume=2.8±1.1mm
3). In a second step, with imaging flow cytometry, we characterized and visualized the PFC-incorporating immune cell populations involved in the inflammation process, which were mainly dendritic cells, macrophages and neutrophils (ratio 9:1:1).}
}
@inproceedings{ISMRM2018_3675,
annote={ISMRM2018_3675},
pages={3675},
file={ISMRM2018_3675.pdf:ISMRM2018_3675.pdf:PDF},
title={Contrast Agent Assessment: Comparison of Quantitative Techniques},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3675.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Matthew Tarasek and Jeannette Roberts and Deirdre Cassidy and Jason Castle and Concetta Gringeri and Desmond Yeo and Randall Carter and Brian Bales},
abstract={Contrast agents are widely used in magnetic resonance imaging (MRI) examinations to enhance the visualization of certain pathologies and anatomical structures to improve diagnostic accuracy. Contrast agents shorten the longitudinal relaxation time (T1) of water molecules and subsequent signal enhancement in T1-weighted (T1W) images can be observed. In this work, we compare quantitative T1W imaging and T1 mapping for detection of contrast agent deposition in select rat brain structures. Results are presented for two distinct brain structures in a cohort of six rats: three saline controls and three injected with manganese chloride contrast agent.}
}
@inproceedings{ISMRM2018_3676,
annote={ISMRM2018_3676},
pages={3676},
file={ISMRM2018_3676.pdf:ISMRM2018_3676.pdf:PDF},
title={Including bone in {DIXON}-based {PET}/{MRI} attenuation correction for primary and recurrent prostate cancer},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3676.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Mattijs Elschot and Kirsten M Selnæs and Håkon Johansen and Brage Krüger-Stokke and Helena Bertilsson and Tone F Bathen},
abstract={Accurate correction for bone attenuation may be important for PET/MRI of prostate cancer due to the high bone-density of the pelvis. In this study we evaluated a previously proposed method that includes bone attenuation coefficients in the DIXON-based attenuation map by co-registration with an atlas of the major bones in the body. We found that the inclusion of bone significantly increased the standardized uptake values of soft tissue lesions, but the effect was only in the order of 3\%. In addition, we observed that bone registration errors were present near 31\% of the lesions, which may hamper widespread clinical applicability.}
}
@inproceedings{ISMRM2018_3677,
annote={ISMRM2018_3677},
pages={3677},
file={ISMRM2018_3677.pdf:ISMRM2018_3677.pdf:PDF},
title={Automated tumour definition in diffusion imaging from Gaussian mixture modelling of intrinsically-registered {PET} data in breast cancer: pilot study},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3677.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Maren Marie Andreassen and Tone Bathen and Pål Erik Goa and Steinar Lundgren and Roja Hedayati and Torill Sjøbakk and Hans Petter Eikesdal and Neil P. Jerome},
abstract={Simultaneous positron emission tomography and magnetic resonance imaging (PET/MRI) is an emerging technique in breast cancer practice, allowing collection of morphologic parameters in addition to real-time metabolism. Though feasibility has been demonstrated, the best approach to utilize PET/MRI has not yet been validated. This study focus on evaluating a Gaussian mixture model (GMM) based segmentation technique from PET images with intrinsic MRI registration as a proxy for regions-of-interest (ROIs) manually drawn on post contrast images. The application of the method has been evaluated in a neoadjuvant treatment response assessment setting using apparent diffusion coefficient (ADC) values.}
}
@inproceedings{ISMRM2018_3678,
annote={ISMRM2018_3678},
pages={3678},
file={ISMRM2018_3678.pdf:ISMRM2018_3678.pdf:PDF},
title={Learning-based attenuation correction for Head and Neck {PET}/{MR}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3678.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Maya Khalifé and Romain de Laroche and Sandeep Kaushik and Brian Sgard and Fernando Pérez-García and Melika Sahli Amor and Didier Dormont and Marie-Odile Habert and Florian Wiesinger and Aurélie Kas},
abstract={PET/MR in head and neck cancer lacks accurate attenuation correction (AC). In this work we implemented and tested three PET/MR-AC methods: 1) Dixon-based AC as used in clinical routine ignoring facial and cervical bones (Dixon), 2) Zero TE (ZTE)-based AC for segmenting bone and combined with Dixon-based fat-water separation (hZTE), 3) a deep learning approach (DL), trained on CT-ZTE datasets. PET images were reconstructed on six patients testing three AC methods (Dixon, hZTE, DL) and compared to reference CT-AC. PET comparison showed underestimated SUV with Dixon-AC, decreased error with hZTE-AC compared to CT-AC and the lowest error with DL-AC.}
}
@inproceedings{ISMRM2018_3679,
annote={ISMRM2018_3679},
pages={3679},
file={ISMRM2018_3679.pdf:ISMRM2018_3679.pdf:PDF},
title={Evaluation of Diagnostic Accuracy of Gallium-68 {DOTATATE} {PET}-{MRI} Hybrid Imaging in Staging and Restaging Neuroendocrine Tumors},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3679.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={James Bai and Robert Matthews and Kavitha Yaddanapudi and Rao Chimpiri and Dinko Franceschi},
abstract={The purpose of our study is to evaluate diagnostic accuracy of DOTATATE PET-MR hybrid imaging in detecting neuroendocrine tumor. We demonstrated Ga-68 PET-MRI has high accuracy in detection of NET in the abdomen and pelvis. Lesion characterization with combined MRI helps to distinguish benign lesions from malignant ones.}
}
@inproceedings{ISMRM2018_3680,
annote={ISMRM2018_3680},
pages={3680},
file={ISMRM2018_3680.pdf:ISMRM2018_3680.pdf:PDF},
title={Ultra-low-dose Amyloid {PET} Reconstruction using Deep Learning with Multi-contrast {MRI} Inputs},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3680.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Kevin T Chen and Enhao Gong and Fabiola Bezerra de Carvalho Macruz and Junshen Xu and Mehdi Khalighi and John Pauly and Greg Zaharchuk},
abstract={Simultaneous PET/MRI is a powerful hybrid imaging modality that allows for perfectly correlated morphological and functional information. With deep learning methods, we propose to use multiple MR images and a noisy, ultra-low-dose amyloid PET image to synthesize a diagnostic-quality PET image resembling that acquired with typical injected dose. This technique can potentially increase the utility of hybrid amyloid PET/MR imaging in clinical diagnoses and longitudinal studies.}
}
@inproceedings{ISMRM2018_3681,
annote={ISMRM2018_3681},
pages={3681},
file={ISMRM2018_3681.pdf:ISMRM2018_3681.pdf:PDF},
title={Radial {MS}-{CAIPIRINHA} Efficiently Extends the Anatomical Coverage in {MR} Myocardial Perfusion Studies on {MR}-{PET} Systems},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3681.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Tobias Wech and Karl P. Kunze and Christoph Rischpler and Daniel Stäb and Peter Speier and Herbert Köstler and Stephan G. Nekolla},
abstract={Integrated MR-PET imaging is a versatile tool for the non-invasive characterization of cardiovascular disease. In this work, we developed an MS-CAIPIRINHA-based imaging technique to extend the anatomical coverage of the MRI perfusion assessment to six slices per RR. As a proof of principle, the described approach was combined with simultaneous 18F-FDG viability imaging and Late Gadolinium Enhancement (LGE) imaging investigating improvements in anatomical coverage for a relevant patient cohort.}
}
@inproceedings{ISMRM2018_3682,
annote={ISMRM2018_3682},
pages={3682},
file={ISMRM2018_3682.pdf:ISMRM2018_3682.pdf:PDF},
title={{PET}coil: Elements of an {RF}-penetrable positron emission tomography insert for simultaneous {PET}/{MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3682.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Brian Jun Lee and Chen-Ming Chang and Ilaria Sacco and Ronald Watkins and Craig S Levin},
abstract={A PET insert dedicated to brain PET/MRI offers several advantages compared to the commercial integrated whole-body PET/MRI systems, including better sensitivity, spatial resolution and significantly lower price. We are developing an RF-penetrable PET insert integrated with a custom RX-only phased-array coil, termed collectively as “PETcoil”, dedicated for brain PET/MRI (30 cm diameter, 16 cm axial FOV). In this presentation, we will present the design and preliminary results of the PETcoil with regards to minimizing mutual interference between the PET and MRI while maintaining excellent performance.}
}
@inproceedings{ISMRM2018_3683,
annote={ISMRM2018_3683},
pages={3683},
file={ISMRM2018_3683.pdf:ISMRM2018_3683.pdf:PDF},
title={Optimization of {MR}-Based Attenuation Correction for Cardiac {PET}/{MR} Using Free-Breathing Multi-Echo Golden-Angle Radial Stack-of-Stars {MR}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3683.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Philip Robson and Thomas Benkert and MariaGiovanna Trivieri and Nicolas Karakatsanis and Ronan Abgral and Marc Dweck and Jason Kovacic and Tobias Block and Zahi Fayad},
abstract={Recently hybrid PET/MR has gained much interest for its potential to combine PET imaging of disease activity with the benefits of cardiac MR. MR-based attenuation correction (MRAC) is an important aspect of accurate PET tracer quantification. For imaging the heart, optimal MRAC is required to both compensate for cardiac motion and also to optimize segmentation of tissues for accurate PET reconstruction. In this work we investigate the use of multi-echo golden-angle radial stack-of-stars MR to combine these 2 key attributes.}
}
@inproceedings{ISMRM2018_3684,
annote={ISMRM2018_3684},
pages={3684},
file={ISMRM2018_3684.pdf:ISMRM2018_3684.pdf:PDF},
title={Metabolic reprogramming in the heart and lung in a murine model of pulmonary arterial hypertension},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3684.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jose Luis Izquierdo-Garcia and Teresa Arias and Yeny Rojas and Jesus Ruiz-Cabello},
abstract={Pulmonary Arterial Hypertension is a rare disease of the pulmonary circulation that produces narrowing of small pulmonary arteries, increasing of pulmonary vascular resistance and right ventricular failure. We studied the associated metabolic reprogramming in lung and heart tissues, which is essential for disease progression, in a mouse model of hypoxia induced PAH. Lung and heart metabolism were monitored by HR-MAS NMR spectroscopy and PET imaging. We identified an alteration in energetic and proliferative metabolism of the lungs. We also found a shift in energy metabolism in cardiac tissue.}
}
@inproceedings{ISMRM2018_3685,
annote={ISMRM2018_3685},
pages={3685},
file={ISMRM2018_3685.pdf:ISMRM2018_3685.pdf:PDF},
title={Applications of {ZTE}-derived Attenuation Correction Maps to Neuropediatric Cases: A Preliminary Analysis},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3685.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Brice Fernandez and Gaspar Delso and Gisèle Depas and Maya Khalifé and Irène Buvat and Claude Comtat and Catherine Chiron},
abstract={PET/MR is a promising imaging modality for pediatric applications due to its lower radiation dose compared to PET/CT. However, commonly implemented MR-derived Attenuation Correction (MRAC) methods have not been fully evaluated for pediatrics brain applications. Consequently, we aimed at comparing different MRAC methods (Atlas, ZTE and High-resolution ZTE) on pediatric patients. Since the current gold standard AC data (i.e. CT) is missing, the different MRAC methods are ranked in comparison with the results found in the literature to determine if current knowledge regarding MRAC methods applied on adults might be extended to the considered pediatric population.}
}
@inproceedings{ISMRM2018_3686,
annote={ISMRM2018_3686},
pages={3686},
file={ISMRM2018_3686.pdf:ISMRM2018_3686.pdf:PDF},
title={Joint estimation applied to attenuation correction for quiescent period respiratory gated {PET} data in {PET}/{MR}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3686.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Sangtae Ahn and Jaewon Yang and Jing Liu and Youngho Seo and Thomas A. Hope and Peder E. Z. Larson and Florian Wiesinger},
abstract={Quiescent period gating of PET data reduces respiratory motion artifacts in PET imaging. However, a respiratory phase mismatch between attenuation map and gated PET data results in PET quantitation errors particularly for lesions in the dome of the liver. To address the problem, we apply a joint estimation (JE) technique to attenuation correction for respiratory phase gated PET data. We demonstrate on clinical PET/MR data that the JE method improves PET quantitation accuracy without an additional process of respiratory phase gating of MR data. JE has additional potential to estimate patient-specific lung tissue density and provide robustness to metallic implants.}
}
@inproceedings{ISMRM2018_3687,
annote={ISMRM2018_3687},
pages={3687},
file={ISMRM2018_3687.pdf:ISMRM2018_3687.pdf:PDF},
title={Quantitative Imaging for Development of {PET}/{MRI} phantoms},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3687.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Peder Eric Zufall Larson and Misung Han and Peng Cao and Hongyu An and Kathryn Fowler and Kathryn Keenan and Karl F. Stupic and Richard Laforest and Thomas Hope},
abstract={This project aims to develop PET/MR phantoms to evaluate MR-based attenuation correction (MRAC) methods and allow standardization of PET results across PET/MRI scanners. This will be accomplished using quantitative ultrashort echo-time (UTE) imaging methods for measurement of T1, T2* and proton density of in vivo tissue types and candidate phantom materials, along with CT measurements of attenuation coefficients. UTE methods are required to characterize bone and choose bone mimics, as this is the most challenging tissue type for MRAC methods to capture.}
}
@inproceedings{ISMRM2018_3688,
annote={ISMRM2018_3688},
pages={3688},
file={ISMRM2018_3688.pdf:ISMRM2018_3688.pdf:PDF},
title={{CSF} transport of 18F and 18{FDG} via the brain-wide glymphatic pathway visualized by Integrative {PET}-{MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3688.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Helene Benveniste and Hedok Lee and Michael Budassi and S. David Smith and Mark Schweitzer and Nora Volkow and Maiken Nedergaard and Paul Vaska},
abstract={The glymphatic pathway was recently re-discovered as a CSF transport system for brain waste removal. The peri-vascular space functions as the ”front end” for toxic waste clearance via the ‘glymphatic pathway. To facilitate future translation to the clinic we executed experiments to map glymphatic transport in the live rodent brain using dynamic integrated MRI-PET imaging in combination with CSF administration of a paramagnetic contrast agent and two different 18F-labeled radioisotopes.}
}
@inproceedings{ISMRM2018_3689,
annote={ISMRM2018_3689},
pages={3689},
file={ISMRM2018_3689.pdf:ISMRM2018_3689.pdf:PDF},
title={Quantification of Oxygen Metabolism in Human Brain: Comparison of Direct
17O with Indirect
1H {MR} Method},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3689.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Dmitry Kurzhunov and Jan Sedlacik and Robert Borowiak and Divya Sanam Bolar and Johannes Fischer and Ali Caglar Özen and Michael Bock},
abstract={In this study, quantification of the cerebral metabolic rate of oxygen consumption (CMRO
2) in human brain using direct dynamic
17O-MRI with inhalation of
17O gas was compared to indirect
1H-MRI using QUantitative Imaging of eXtraction of Oxygen and TIssue Consumption (QUIXOTIC) method. The CMRO
2 results of both methods are in a good agreement with
15O-PET studies (
17O-MRI: 0.83–1.09/1.13–1.48 µmol/g
tissue/min in WM/GM regions;
1H-MRI: 0.40–1.45/0.74–1.73 µmol/g
tissue/min in WM/GM regions). QUIXOTIC offers smaller pixels which also results in a higher variation of CMRO
2 values, whereas MRI with the intracellular tracer
17O provides averaged values with less variation due to the lower spatial resolution.}
}
@inproceedings{ISMRM2018_3690,
annote={ISMRM2018_3690},
pages={3690},
file={ISMRM2018_3690.pdf:ISMRM2018_3690.pdf:PDF},
title={Robust {MR}-based attenuation correction for {PET} near metal implants},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3690.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Daehyun Yoon and Mohammad Mehdi Khalighi and Xinwei Shi and Harsh Gandhi and Dawn Holley and Sandip Biswal and Brian Andrew Hargreaves},
abstract={In simultaneous PET/MRI, the reconstruction of PET image uses an MRI-based attenuation coefficient (AC) map for accurate quantization of radiotracer activity. The AC map is typically derived from SPGR images, but these are severely distorted near metallic implants due to strong off-resonance artifacts. We investigated the influence of the metal artifacts in the MR-based AC map upon the PET image accuracy. To correct the metal artifacts in PET, we present the use of multi-spectral imaging with field-map-based determination of meta boundary and type. Our correction result mitigated the signal underestimation near metal in PET images from 50\% to 8\%.}
}
@inproceedings{ISMRM2018_3691,
annote={ISMRM2018_3691},
pages={3691},
file={ISMRM2018_3691.pdf:ISMRM2018_3691.pdf:PDF},
title={Metabolic Interactions of Simultaneous 18F-{FDG} {PET} and Hyperpolarized 13C {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3691.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Mette H. Lauritzen and Milton Merchant and Taichang Jang and Keshav Datta and Ralph E. Hurd and Shie-Chau Liu and Jae Mo Park and Lawrence Recht and Daniel M. Spielman},
abstract={Simultaneous hyperpolarized
13C-pyruvate MRI and
18F-FDG PET imaging have the several potential applications, especially for understanding the complex metabolic processes of cancer. However, we hypothesized the relatively high concentrations of
13C-pyruvate used in hyperpolarized MRI could interfere with the
18F-FDG uptake when administrated simultaneously, because their metabolic products compete for the same pathways. In this study, we examined the effect of injected pyruvate and lactate on
18F-FDG uptake in healthy rats and in rats with implanted C6 gliomas and discuss the metabolic interactions observed.}
}
@inproceedings{ISMRM2018_3692,
annote={ISMRM2018_3692},
pages={3692},
file={ISMRM2018_3692.pdf:ISMRM2018_3692.pdf:PDF},
title={M2 Tumor Associated Macrophage Targeted Magnetic Resonance Imaging Using Mannose Conjugated Anti-Biofouling Iron Oxide Nanoparticle Probes},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3692.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yuancheng Li and Liya Wang and Hui Wu and Weiping Qian and Bing Ji and Lily Yang and Hui Mao},
abstract={By reducing non-specific macrophage uptake, anti-biofouling polymer coated iron oxide nanoparticles (IONPs) conjugated with mannose as the ligand (Man-IONP) was developed for specifically targeting sub-type tumor associated macrophage M2 with mannose receptor 1 expression. This novel MRI probe demonstrated specific M2 macrophage targeting in vitro with M1 and R264.7 macrophages as controls. Immuno-staining of 4T1 breast tumor tissues with Man-IONPs showed the probe targeting M2 similarly to anti-CD206 antibody. NIR and MR imaging of 4T1 tumor-bearing mice showed significant contrast changes after receiving i.v. injection of NIR dye labeled Man-IONP, while little change was observed for mice receiving non-targeted IONP.}
}
@inproceedings{ISMRM2018_3693,
annote={ISMRM2018_3693},
pages={3693},
file={ISMRM2018_3693.pdf:ISMRM2018_3693.pdf:PDF},
title={Manganese Complex of {EDTA}-Ethoxybenzyl Conjugate as a New Hepatobiliary {MRI} Contrast Agent},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3693.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Md Kamrul Islam and Soyeon Kim and Hee-Kyung Kim and Garam Choi and Ah Rum Baek and Taekwan Lee and DongKyu Kim and Hoe Su Jung and Yongmin Chang},
abstract={The purpose of the current study is to design and synthesis of novel Mn
2+ complex as an alternative to well-established Gd
3+ chelates for use as a liver-targeting MR imaging agent. This new complex exhibits high R
1 relaxivity (2.3 mM
−1 s
−1) than clinically approved Mn-DPDP® (1.6 mM
−1 s
−1) at 1.5 T. It is also kinetically much inert than that of Magnevist®. In vivo MRI enhancement pattern compares well with those of liver-specific MRI CAs such as Primovist® and Multihance®. It shows greater tumor detection in a liver tumor model with negligible toxicity in a clinical dose.}
}
@inproceedings{ISMRM2018_3694,
annote={ISMRM2018_3694},
pages={3694},
file={ISMRM2018_3694.pdf:ISMRM2018_3694.pdf:PDF},
title={Gadolinium complexes conjugated with nonsteroidal anti-inflammatory drugs ({NSAID}s) as potential inflammation targeting {MRI} contrast agents.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3694.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Heekyung Kim and Bokyung Sung and Soyeon Kim and Garam Choi and Ah Rum Baek and Md Kamrul Islam and Taekwan Lee and DongKyu Kim and Hoe Su Jung and Yongmin Chang},
abstract={Inflammation targeting MR CAs conjugated with NSAIDs were prepared according to the general synthetic methods and characterized by spectroscopic analysis. The relaxivities of theses gadolinium complexes are slightly higher than those of Gadovist®. From in vivo T
1-weighted MR images, strong enhancement was observed in the inflammatory region. Also our new gadolinium complexes represent high kinetic inertness in chemically competitive environment compared with other clinically used MR CAs.}
}
@inproceedings{ISMRM2018_3695,
annote={ISMRM2018_3695},
pages={3695},
file={ISMRM2018_3695.pdf:ISMRM2018_3695.pdf:PDF},
title={Small CaF2 nanocrystals as nano-sized tracers for in vivo 19F-{MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3695.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Idan Ashur and Hyla Allouche-Arnon and Amnon Bar-Shir},
abstract={In this study we present a novel class of
19F-nanoformulations based on small (<10 nm) fluoride-nanocrystals (specifically CaF
2 nanofluorides) for MRI applications. We show that homonuclear dipolar interactions can be averaged out by the fast tumbling of the PEG-coated nanocrystals thus enabling the acquisition of high-resolution
19F-NMR. Using this feature, we demonstrate that our newly developed nanofluorides could be used as
19F-MRI tracers and present a “hot-spot” mapping in an animal model inflammation. The proposed nanofluorides combine the advantages of using nanocrystals (small, high
19F-equivalency, maximal
19F-density and surface modifiability) with the merits of
19F-MRI tracers.}
}
@inproceedings{ISMRM2018_3696,
annote={ISMRM2018_3696},
pages={3696},
file={ISMRM2018_3696.pdf:ISMRM2018_3696.pdf:PDF},
title={Fluorine labeling and imaging of biomaterial scaffolds for regenerative medicine},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3696.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Marcin Piejko and Piotr Walczak and Xiaowei Li and Jeff W.M. Bulte and Miroslaw Janowski},
abstract={There is growing interest in stem cell-based regenerative medicine. Hydrogels can serve as injectable scaffolds for transplanted stem cells in order to provide mechanical support, as well as to mimic natural 3D tissue composition, while allowing for minimally invasive needle- or catheter-based delivery. However, the precision of hydrogel injections, as well as monitoring of gel biodegradation, remains challenging. We have shown that clinical grade fluorine nanoemulsion effectively and firmly labels hyaluronian-based hydrogel, supports survival of embedded stem cells, while only mildly changing rheological properties. Additionally, 19F MRI is very attractive as it does not interfere with anatomical and functional MRI.
}
}
@inproceedings{ISMRM2018_3697,
annote={ISMRM2018_3697},
pages={3697},
file={ISMRM2018_3697.pdf:ISMRM2018_3697.pdf:PDF},
title={Toward investigating cerebral metabolism using hyperpolarized pyruvate on a human 7T system},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3697.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Sergey Cheshkov and Edward Hackett and Richard Martin and Sandeep Ganji and Ivan Dimitrov and Jae Mo Park},
abstract={Advances in hyperpolarized MR technology and pre-clinical investigations have recently led to translational studies using clinical 3T human systems. While hyperpolarization provides large increase in MR sensitivity, spectral dispersion at 3T is limited which makes assessment of various metabolic pathways difficult. This work demonstrates the feasibility of using hyperpolarized
13C-pyruvate to study brain metabolism in a whole-body human 7T system. In particular, the benefit of increased chemical shift dispersion and
1H-decoupling were tested in phantom and rat brains in vivo using hyperpolarized [1-
13C]- and [2-
13C]-labeled pyruvate. Longitudinal relaxation times of these hyperpolarized substrates at 7T are also reported.}
}
@inproceedings{ISMRM2018_3698,
annote={ISMRM2018_3698},
pages={3698},
file={ISMRM2018_3698.pdf:ISMRM2018_3698.pdf:PDF},
title={Integrated B1+ Mapping for Hyperpolarized 13C {MRI} in a Clinical Setup using Multi-Channel Receive Arrays},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3698.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Rie B Hansen and Peter J Shin and Jeremy W Gordon and Mark Van Criekinge and Lucas Carvajal and Lars G Hanson and Jan H Ardenkjær-Larsen and Daniel B Vigneron},
abstract={For hyperpolarized
13C MRI acquisitions aimed at metabolic rate constant estimation, the Bloch-Siegert shift enables encoding of the transmit field (B
1+-field) amplitude within a single hyperpolarized substrate injection. This ability is needed since most clinical hyperpolarized MRI studies use inhomogeneous transmit coils and because kinetic modeling based on incorrect flip angles can lead to incorrect rate constant estimations. This study demonstrates the feasibility of integrated B
1+ mapping for large volume thermal and hyperpolarized phantoms in a clinical setup using a clamshell transmit coil and a 16-channel receive array and a 3D stack-of-spirals sequence. Phase-sensitive coil-combination was achieved using ESPIRiT.}
}
@inproceedings{ISMRM2018_3699,
annote={ISMRM2018_3699},
pages={3699},
file={ISMRM2018_3699.pdf:ISMRM2018_3699.pdf:PDF},
title={Hyperpolarized [1-13C]pyruvate {MRS} detects dynamic glucose metabolism according to stages of diabetes in mouse model},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3699.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Young-suk Choi and Somang Kang and Hansol Lee and Jae Eun Song and Dong-Hyun Kim and Jong Eun Lee and Ho-Taek Song},
abstract={Recently, diabetes has been suggested as a risk factor for inducing cognitive impairment. Thus, a quantitative imaging method to validate the metabolic status of the brain according to the stages of diabetes may help elucidate the relationship between the development of cognitive impairment and glucose metabolism of the brain. This study performed hyperpolarized [1-13C]pyruvate imaging in the brain of both pre-diabetes (Pre-DM) and type 2 diabetes (T2DM) mouse model. It shows dynamic brain glucose metabolism according to the stages of diabetes with excellent sensitivity.}
}
@inproceedings{ISMRM2018_3700,
annote={ISMRM2018_3700},
pages={3700},
file={ISMRM2018_3700.pdf:ISMRM2018_3700.pdf:PDF},
title={Hyperpolarized carbon-13 {MRS} of liver in a high-fat/high sugar diet guinea pig model},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3700.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Lauren Smith and Lanette Friesen-Waldner and Kevin Sinclair and Trevor Wade and Timothy Regnault and Charles McKenzie},
abstract={Effects of a life long high-fat/high sugar diet (Western diet: WD) upon pyruvate liver metabolism were observed in a group of young adult male guinea pigs (N=26). Proton density fat-fraction images were reconstructed using IDEAL water fat separation. Metabolism data were obtained using dynamic spectroscopy of hyperpolarized carbon-13 enriched pyruvate. Guinea pigs fed a life long WD displayed a significantly higher hepatic fat fraction and a delayed time to peak for the conversion of pyruvate to lactate. These results indicate that life long consumption of a WD in growing animals is associated with markers of dysfunctional hepatic metabolic function.}
}
@inproceedings{ISMRM2018_3701,
annote={ISMRM2018_3701},
pages={3701},
file={ISMRM2018_3701.pdf:ISMRM2018_3701.pdf:PDF},
title={Case Report: Hyperpolarized 13C Metabolic Imaging of a Castration-Resistant Prostate Cancer Patient},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3701.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Casey Y. Lee and Benjamin J. Geraghty and Justin Y. C. Lau and Albert P. Chen and William J. Perks and Masoom A. Haider and Urban Emmenegger and Charles H. Cunningham},
abstract={The feasibility of applying hyperpolarized
13C MRI to acquire metabolic (lactate, pyruvate) images of the vertebral region of a castration-resistant prostate cancer patient was investigated in this pilot study. The lactate and pyruvate signal-to-noise ratios (SNRs) of spine, back muscle, aorta and kidney are reported. The summary of patient’s clinical history is illustrated to aid the understanding of implications of
13C-lactate signals observed in this study.}
}
@inproceedings{ISMRM2018_3702,
annote={ISMRM2018_3702},
pages={3702},
file={ISMRM2018_3702.pdf:ISMRM2018_3702.pdf:PDF},
title={Correlation Between Hyperpolarized 13C-signal and Lactate Concentration in a Human Breast Cancer Xenograft Model},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3702.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Casey Y. Lee and Benjamin J. Geraghty and Justin Y. C. Lau and Albert P. Chen and Yi-Ping Gu and Charles H. Cunningham},
abstract={Hyperpolarized
13C MRI has enabled metabolic (lactate- and pyruvate-) imaging in various clinical and pre-clinical studies to probe the production of lactate in tumours. A number of biological factors has been proposed to influence
13C-signal, with the total lactate pool size thought to be the dominant contributor based on the in vitro cell study by Day et al. In this study, we investigate whether the same relationship holds in a human breast cancer xenograft model in rats, as well as assessing the contributions from other biological components, including the rate of perfusion, transporters and enzymes.}
}
@inproceedings{ISMRM2018_3703,
annote={ISMRM2018_3703},
pages={3703},
file={ISMRM2018_3703.pdf:ISMRM2018_3703.pdf:PDF},
title={Noninvasive assessment of treatment response to histone deacetylase inhibitor and radiation for pediatric diffuse midline glioma using hyperpolarized carbon-13 metabolic imaging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3703.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ilwoo Park and Adam Autry and Xiaodong Yang and Yuying Zhai and Renuka Sriram and Dave Korenchan and John Kurhanewicz and Adam Cunha and I-Chow Hsu and Sabine Mueller},
abstract={Diffuse midline glioma is one of the most difficult pediatric cancers to treat. This study investigated the feasibility of
13C magnetic resonance metabolic imaging of hyperpolarized [1-
13C]pyruvate for monitoring response to novel therapies in diffuse midline glioma. Treatment with panobinostat was associated with a reduction in hyperpolarized lactate and a reduced LDHA activity in an in vitro experiment. Radiotherapy led to a reduction in the ratio of lactate to pyruvate in rats bearing diffuse midline glioma. The results suggest that hyperpolarized
13C metabolic imaging may provide an early noninvasive biomarker to monitor therapy response in diffuse midline glioma.}
}
@inproceedings{ISMRM2018_3704,
annote={ISMRM2018_3704},
pages={3704},
file={ISMRM2018_3704.pdf:ISMRM2018_3704.pdf:PDF},
title={Establishing a Dose-Response Relationship for Lithium-Induced Modulation of [1-13C]Pyruvate Metabolism in the Heart},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3704.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jonas Steinhauser and Patrick Wespi and Grzegorz Kwiatkowski and Sebastian Kozerke},
abstract={Lithium is the first-line drug used in bipolar disorder, a chronic widespread psychiatric disease. Lithium is a narrow therapeutic index drug and shows cardiac side effects. The present work demonstrates the detectability of lithium induced changes of mitochondrial metabolism in cardiomyocytes using hyperpolarized [1-13C]pyruvate magnetic resonance imaging of the in-vivo rat heart. Metabolic and functional response to lithium was examined for different lithium plasma concentrations.}
}
@inproceedings{ISMRM2018_3705,
annote={ISMRM2018_3705},
pages={3705},
file={ISMRM2018_3705.pdf:ISMRM2018_3705.pdf:PDF},
title={In Vivo Imaging with Hyperpolarized Aspirin},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3705.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Argentina Ornelas and Niki Zacharias Millward and Jaehyuk Lee and Jingzhe Hu and David Menter and Eduardo Vilar Sanchez and Pratip K Bhattacharya and Steven Wesley Millward},
abstract={Epidemiological evidence strongly suggests that chronic low-dose aspirin usage leads to a significantly lower incidence of cancer and metastatic disease. Given its emergent role as a chemopreventive, it is highly desirable to develop a method to monitor aspirin pharmacokinetics and metabolism in real time and in vivo. We have recently synthesized and hyperpolarized single and double 13C-labeled aspirin, monitored chemical acetylation in hyperpolarized phantom experiments and determined metabolism and biodistribution of hyperpolarized 13C aspirin in mice.}
}
@inproceedings{ISMRM2018_3706,
annote={ISMRM2018_3706},
pages={3706},
file={ISMRM2018_3706.pdf:ISMRM2018_3706.pdf:PDF},
title={Pulmonary Metabolism and Inflammation During Mechanical Ventilation: A Hyperpolarized Carbon-13 Study},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3706.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Mehrdad Pourfathi and Shampa Chatterjee and Maurizio Cereda and Yi Xin and Stephen Kadlecek and Hooman Hamedani and Ian Duncan and Sarmad Siddiqui and Harrilla Profka and Kai Ruppert and Luis Loza and Faraz Amzajerdian and Ryan Baron and Mary Spencer and Tahmina Achekzai and Rahim R. Rizi},
abstract={We showed that secondary inflammation due to atelectasis increases pulmonary anaerobic metabolism (lactate-to-pyruvate ratio). Recruitment with PEEP limits anaerobic metabolism and contains injury progression. Measuring tissue metabolism with hyperpolarized MRI can disclose novel pathways of tissue damage during lung injury and assess secondary injury progression in ventilated lungs.}
}
@inproceedings{ISMRM2018_3707,
annote={ISMRM2018_3707},
pages={3707},
file={ISMRM2018_3707.pdf:ISMRM2018_3707.pdf:PDF},
title={Imaging Regional Distribution of Metabolic Activity During Progression of Acute Lung Injury using Hyperpolarized Carbon-13 {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3707.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Mehrdad Pourfathi and Maurizio Cereda and Shampa Chatterjee and Yi Xin and Stephen Kadlecek and Hooman Hamedani and Ian Duncan and Sarmad Siddiqui and Harrilla Profka and Kai Ruppert and Luis Loza and Faraz Amzajerdian and Ryan Baron and Mary Spencer and Tahmina Achekzai and Rahim R. Rizi},
abstract={We used hyperpolarized [1-
13C] pyruvate MRI to assess regional alterations in lactate production during progression of acute lung injury. While the average lactate-to-pyruvate ratio and its standard deviation increased globally in lungs ventilated without recruitment, the average ratio increased more significantly in the posterior regions than the average ratio in the anterior region. The average lactate-to-pyruvate remained unchanged in lungs ventilated with recruitment maneuver. Our finding suggests that stretch-induced atelectasis and inflammation are the root of increased lactate-to-pyruvate ratio in the lungs ventilated without recruitment.}
}
@inproceedings{ISMRM2018_3708,
annote={ISMRM2018_3708},
pages={3708},
file={ISMRM2018_3708.pdf:ISMRM2018_3708.pdf:PDF},
title={Evaluating hyperpolarized lactate as a theranostic agent for stroke},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3708.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jean-Noël Hyacinthe and Lara Buscemi and Mario Lepore and Rolf Gruetter and Lorenz Hirt and Mor Mishkovsky},
abstract={Stroke is the leading cause of disability and the third leading cause of death worldwide. Lactate administration into the ischemic brain directly after blood reperfusion was found to be neuroprotective. MR with hyperpolarized (HP) probes enables in vivo real-time measurement of biochemical transformations of HP
13C-labeled precursors, including lactate. The aim of this study was to demonstrate the feasibility of probing HP [1-
13C]L-lactate metabolism in mice brain after ischemic stroke and to study the influence of the time window after reperfusion on its conversion in order to evaluate the potential of HP lactate as a theranostic agent for stroke.}
}
@inproceedings{ISMRM2018_3709,
annote={ISMRM2018_3709},
pages={3709},
file={ISMRM2018_3709.pdf:ISMRM2018_3709.pdf:PDF},
title={Imaging metabolic development of patient-derived glioblastoma xenografts in vivo employing hyperpolarized magnetic resonance},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3709.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Travis Salzillo and Joy Gumin and Jaehyuk Lee and Islam Hassan and Niki Zacharias and Rivka Colen and Frederick Lang and Pratip Bhattacharya},
abstract={Hyperpolarized MRI was employed to non-invasively assess aerobic glycolysis in a well-characterized, patient-derived, orthotopic glioblastoma mouse model which recapitulates the complexity of tumor microenvironment. Aberrant energy metabolism is a hallmark of cancer and in order to understand this metabolic rewiring during the course of tumor development, in vivo hyperpolarized pyruvate metabolic imaging and NMR spectroscopy of ex vivo tumor tissue were performed at three separate time points. A positive correlation of dynamic lactate production with tumor progression was observed. Additionally, NMR metabolomics revealed several key metabolites that are positively or negatively correlated with tumor growth.}
}
@inproceedings{ISMRM2018_3710,
annote={ISMRM2018_3710},
pages={3710},
file={ISMRM2018_3710.pdf:ISMRM2018_3710.pdf:PDF},
title={Hyperpolarized [1-13C] pyruvate as a biomarker for treatment monitoring in lymphoma murine models},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3710.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Brice Tiret and Adam Autry and IlWoo Park and Min Lu and Rana Anjum and Lisa Drew and Sebastien Degorce and Michele Mayo and Keith Dillman and John Kurhanewicz and James Rubenstein and Myriam Chaumeil},
abstract={In primary CNS lymphoma (PCNSL), MYD88 mutation is the most common and induces a constitutive activation of IRAK4 and NF-kB signaling. AZ1495, a IRAK4inhibitor, significantly improved OS in MYD88mut PCNSL models, highlighting the clinical potential of IRAK inhibition. However, monitoring of such targeted therapies remains challenging using conventional imaging. Because NF-kB controls metabolism, we questioned if hyperpolarized 13C MRSI could monitor IRAK inhibition in PCNSL. We show that HP-13C MRSI was able to detect a decreased HP lactate production following IRAK inhibition in MYD88mut tumors, not wild-types, highlighting the potential of metabolic imaging for monitoring therapy response in lymphomas.}
}
@inproceedings{ISMRM2018_3711,
annote={ISMRM2018_3711},
pages={3711},
file={ISMRM2018_3711.pdf:ISMRM2018_3711.pdf:PDF},
title={Hyperpolarized In vivo pH Imaging Reveals Grade-Dependent Interstitial Acidification},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3711.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={David E Korenchan and Robert Bok and Renuka Sriram and Romelyn Delos Santos and Hecong Qin and Daniel B Vigneron and David M Wilson and John Kurhanewicz and Robert R Flavell},
abstract={Changes in cellular metabolism, perfusion and proton export that occur during indolent-to-aggressive transition in prostate cancer (PCa) likely lead to a lower extracellular pH (pH
e) in vivo, promoting an aggressive, treatment-resistant phenotype. To measure this interstitial acidification, we implemented a hyperpolarized (HP) imaging protocol that measured lactate-to-pyruvate ratio, perfusion and pH
e in a murine model of prostate cancer, the TRAMP mouse. Our results indicated higher pyruvate-to-lactate conversion, lower perfusion and lower pH
e in high-grade tumors, suggesting a correlation between the three parameters and implicating low pH
e in the development of aggressive PCa.}
}
@inproceedings{ISMRM2018_3712,
annote={ISMRM2018_3712},
pages={3712},
file={ISMRM2018_3712.pdf:ISMRM2018_3712.pdf:PDF},
title={Characterization of Distinctive in vivo Metabolism between Enhancing and Non-enhancing Brain Tumors Using Hyperpolarized Carbon-13 {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3712.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Seongwoong Kang and Ilwoo Park},
abstract={This study applied
13C MR metabolic imaging with hyperpolarized [1-
13C]pyruvate for the differential characterization of metabolic profiles between enhancing and non-enhancing brain tumors. The levels of lactate, which was normalized by vascular total carbon signal, were significantly different between the contralateral brain, non-enhancing and enhancing tumor, while the levels of pyruvate were similar between these three tissues. The results from this study suggested that this technique may be useful in distinguishing functional characteristics between normal brain tissue and heterogeneous anatomical lesions in brain tumors.}
}
@inproceedings{ISMRM2018_3713,
annote={ISMRM2018_3713},
pages={3713},
file={ISMRM2018_3713.pdf:ISMRM2018_3713.pdf:PDF},
title={Detection of Targeted Therapy Treatment Response using Hyperpolarized Magnetic Resonance Spectroscopy in Breast Cancer Cell Lines},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3713.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Sui Seng Tee and Kristin L Granlund and Roozbeh Eskandari and Sangmoo Jeong and Steven Truong and Kayvan Rahimi Keshari},
abstract={Hyperpolarized magnetic resonance spectroscopy (HP-MRS) allows non-invasive real-time monitoring of cancer metabolism. This unique ability allows investigation of changes in cancer metabolism after therapy. This study demonstrates the utility of this modality to detect lowered conversion of hyperpolarized pyruvate to lactate after targeted therapy against a commonly mutated growth signaling pathway in cancer. We also demonstrate changes in enzyme phosphorylation that may explain changes in HP-MRS.}
}
@inproceedings{ISMRM2018_3714,
annote={ISMRM2018_3714},
pages={3714},
file={ISMRM2018_3714.pdf:ISMRM2018_3714.pdf:PDF},
title={{HP} [1-13C] Pyruvate-derived metabolic biomarkers are an early predictor of lung rejection in the rat lung transplantation model},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3714.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Sarmad Siddiqui and Mehrdad Pourfathi and Andreas Habertheuer and Yi Xin and Hooman Hamedani and Prashanth Vallabhajosyula and Ali Naji and Rahim R. Rizi},
abstract={Post-transplant lungs are clinically monitored using regular radiography and/or CT scans to detect rejection. We proposed that a metabolic biomarker may provide higher sensitivity than conventional tools at the onset of rejection, before permanent structural changes in the lungs. Using HP [1-13C] pyruvate CSI, we found that the HP lactate-to-pyruvate ratio in the transplanted lung was significantly elevated in the rejected cohort (~1.7-fold on day 3, ~2.7-fold on day 7) compared to the non-rejected cohort and can be potentionally used as an early predictor of lung rejection.}
}
@inproceedings{ISMRM2018_3715,
annote={ISMRM2018_3715},
pages={3715},
file={ISMRM2018_3715.pdf:ISMRM2018_3715.pdf:PDF},
title={A Multimodal Imaging Approach to Characterize the Onset of Pulmonary Fibrosis},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3715.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Sarmad Siddiqui and Mehrdad Pourfathi and Stephen Kadlecek and Yi Xin and Harrilla Profka and Rahim R. Rizi},
abstract={Pulmonary fibrosis is typically an progressive, irreversible disease. However, in many cases, the onset of fibrosis is preceded by persistent inflammation; unfortunately, the two presentations are challenging to assess radiologically and misdiagnoses can limit treatment options. In this in vivo rat study, the metabolic state the lung—derived via HP [1-13C]-pyruvate MRSI—and the structural heterogeneity of the lung—imaged via CT—were used in tandem to distinguish healthy lungs, inflamed lungs and lungs with early onset fibrosis, creating an extremely sensitive tool for differentiating between the different phases of pulmonary fibrosis.}
}
@inproceedings{ISMRM2018_3716,
annote={ISMRM2018_3716},
pages={3716},
file={ISMRM2018_3716.pdf:ISMRM2018_3716.pdf:PDF},
title={Investigating Ferumoxytol as a Relaxation Agent for Hyperpolarized 13C Magnetic Resonance},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3716.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Michael A. Ohliger and Cornelius von Morze and Jeremy Gordon and Eugene Milshteyn and Chengcheng Zhu and David Saloner and John Kurhanewicz and Daniel Vigneron},
abstract={Hyperpolarized carbon-13 MRI is a powerful emerging molecular imaging technique but it lacks tissue specificity. Selective relaxation of hyperpolarized signals by targeted gadolinium chelates has been explored to increase specificity. However, gadolinium agents have very low
13C relaxivities. We explore the use of the super paramagnetic iron oxide, ferumoxytol, by measuring the transverse and longitudinal relaxivity for two commonly imaged hyperpolarized
13C metabolites, namely [1-
13C]pyruvate and [1-
13C]lactate in comparison to gadopentetate. Longitudinal relaxivity of ferumoxytol is nearly 30 times higher for 13C compounds than gadopentetate. This enhanced relaxivity is expected to lead to especially low dose requirements in eventual biological translation.}
}
@inproceedings{ISMRM2018_3717,
annote={ISMRM2018_3717},
pages={3717},
file={ISMRM2018_3717.pdf:ISMRM2018_3717.pdf:PDF},
title={Developing a therapeutic strategy for a glycolytic cancer model by monitoring on-target in vivo efficacy of a newly developed {LDH} inhibitor using hyperpolarized 13C Magnetic Resonance Imaging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3717.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Nobu Oshima and Shun Kishimoto and Krisitin Beebe and Dan Crooks and Kazutoshi Yamamoto and Jeffery R. Brender and Ganesha Rai and Daniel Urban and Goria Benavides and Giuseppe Squadrito and Victor Darley-Usmar and Matt Hall and James B. Mitchell and Murali C. Krishna and Leonard M. Neckers},
abstract={This study aimed to develop a new therapeutic strategy with a novel Lactate Dehydrogenase A inhibitor (LDHi) for cancers bearing the Warburg phenotype by monitoring the impact on in vivo metabolic flux of the LDHi using hyperpolarized
13C-MRI.
13C-MRI with hyperpolarized [1-
13C]pyruvate revealed in vivo pharmacodynamics and an effective dose of the LDHi without the need for tissuse sampling. In addition, based on these results, we developed a therapeutic strategy with the LDHi for mice harboring a MiaPaCa-2 (a glycolytic pancreatic cancer cell line) xenograft. This methodology can be a novel approach to treat glycolytic cancers.}
}
@inproceedings{ISMRM2018_3718,
annote={ISMRM2018_3718},
pages={3718},
file={ISMRM2018_3718.pdf:ISMRM2018_3718.pdf:PDF},
title={Esterase-catalyzed production of hyperpolarized 13C carbon dioxide in tissues for measuring pH},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3718.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Nesmine R Maptue and Weina Jiang and Alexander M Funk and Wei Chen and Craig R Malloy and A. Dean Sherry and Chalermchai Khemtong},
abstract={
13C-MRI HP
13C-bicarbonate (H
13CO
3-) and carbon dioxide (
13CO
2) is a novel technique for tissue pH mapping. Here, we report
13C-enriched ethyl acetyl carbonate (
13C-EAC) for esterase-catalyzed production of HP-
13CO
2 and HP-H
13CO
3- for pH measurements. Our results showed that
13C-EAC was rapidly hydrolyzed by esterase to
13C-monoacetyl carbonate, which decomposed to HP-
13CO
2. Equilibrium between the newly produced
13CO
2 and H
13CO
3- was established and the
13C-NMR signals can be quantified for pH measurements. Finally, in vivo pH measurements using H-
13C-EAC was demonstrated in rat livers. These results suggest that HP-
13C-EAC is a novel imaging probe for in vivo pH measurements of tissues.}
}
@inproceedings{ISMRM2018_3719,
annote={ISMRM2018_3719},
pages={3719},
file={ISMRM2018_3719.pdf:ISMRM2018_3719.pdf:PDF},
title={Hyperpolarized [13C,15N2]urea T2 relaxation changes in acute kidney injury},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3719.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Christian Østergaard Mariager and Per Mose Nielsen and Haiyun Qi and Steffen Ringgaard and Christoffer Laustsen},
abstract={BOLD T2* MRI is a surrogate marker of tissue pO2 alterations associated with renal disease, but is limited by perfusion. Hyperpolarized [13C,15N2]urea is an alternative marker of renal function that correlates with normal renal oxygenation. We investigated the correlation between BOLD T2* and 13C-urea T2 in an acute kidney injury (AKI) model. We found that hyperpolarized urea T2 correlates with renal BOLD T2* in the healthy but not in the AKI kidney and that whole kidney T2 is modulated significantly by the blood volume in addition to oxygen availability. 13C-urea T2 mapping therefore has potential to assist the BOLD estimation.}
}
@inproceedings{ISMRM2018_3720,
annote={ISMRM2018_3720},
pages={3720},
file={ISMRM2018_3720.pdf:ISMRM2018_3720.pdf:PDF},
title={Hyperpolarized [1-13C]pyruvate {MRS} reveals early-phase transition of energy metabolism in multicellular spheroid tumors},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3720.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yoichi Takakusagi and Kaori Takakusagi and Kaori Inoue and Kazuhiro Ichikawa},
abstract={Hyperpolarized [1-
13C]pyruvate MRS was conducted to directly monitor the transition of energy metabolism in tiny multicellular tumor spheroids as a model of early tumorigenesis. As compared with normal tumor cells, the lactate formation from pyruvate was significantly amplified in the tumor spheroids, even in a few hundred micrometer i.d. of smaller ones with no blood vessel formation. These results imply that formation of the sterical structure itself causes the transition of energy metabolism from mitochondria to cytoplasm in tumor tissues. HP [1-
13C]pyruvate MRS may thus allow detection of early tumorigenesis by targeting the increased aerobic glycolysis in the initial stage, if much higher performance of HP measurement is realized.
}
}
@inproceedings{ISMRM2018_3721,
annote={ISMRM2018_3721},
pages={3721},
file={ISMRM2018_3721.pdf:ISMRM2018_3721.pdf:PDF},
title={Brain microstructural abnormalities in cirrhotic patients without overt hepatic encephalopathy: A voxel-based diffusional kurtosis imaging study},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3721.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Hua-Jun Chen},
abstract={Brain microstructural change in cirrhotic patients without overt hepatic encephalopathy: A DKI study}
}
@inproceedings{ISMRM2018_3722,
annote={ISMRM2018_3722},
pages={3722},
file={ISMRM2018_3722.pdf:ISMRM2018_3722.pdf:PDF},
title={Altered Dynamic Functional Connectivity in the Default Mode Network in Patients with Cirrhosis and Minimal Hepatic Encephalopathy},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3722.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Hua-Jun Chen},
abstract={Altered Dynamic Functional Connectivity in Default Mode Network in Minimal Hepatic Encephalopathy}
}
@inproceedings{ISMRM2018_3723,
annote={ISMRM2018_3723},
pages={3723},
file={ISMRM2018_3723.pdf:ISMRM2018_3723.pdf:PDF},
title={Quantitative {MRI} comparison of neurological and hepatic forms of Wilson disease},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3723.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Monika Dezortova and Vit Herynek and Petr Dusek and Julio Acosta-Cabronero and Radan Bruha and Filip Jiru and Milan Hajek},
abstract={We examined 40 patients with neurological and hepatic form of Wilson disease by susceptibility mapping at 3T and T1 and T2 relaxometry at 1.5T and 3T. We were able to distinguish patients with neurological form from hepatic form and healthy controls based on quantitative relaxometry and susceptibility mapping. Higher susceptibility observed in the globus pallidus, putamen and caudate nucleus in patients with neurological form corresponds to higher iron content while higher susceptibility in the thalamus corresponds rather to demyelination.}
}
@inproceedings{ISMRM2018_3724,
annote={ISMRM2018_3724},
pages={3724},
file={ISMRM2018_3724.pdf:ISMRM2018_3724.pdf:PDF},
title={Global Cerebral Metabolic Rate of Oxygen in Older People: Gender Differences},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3724.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ana E Rodríguez-Soto and John A Detre and David A Wolk and Joseph E Harrison and Felix W Wehrli},
abstract={Cerebral metabolic rate of oxygen (CMRO
2) has been reported to vary as a function of age and gender. Here, we re-examined possible gender differences as part of an ongoing study in people over the age of 60 years by means whole-brain MR oximetry. Data corroborate earlier findings that cognitively normal females appear to have higher CMRO
2 than their male peers. This difference may be largely due to greater oxygen extraction rather than changes in cerebral blood flow. Possible biological causes of this gender bias will need detailed scrutiny, as do the underlying physiologic assumptions that may impact the results.}
}
@inproceedings{ISMRM2018_3725,
annote={ISMRM2018_3725},
pages={3725},
file={ISMRM2018_3725.pdf:ISMRM2018_3725.pdf:PDF},
title={Tract based spatial statistics analysis of {DKI} metrics in type 2 diabetes patients},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3725.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Zaheer Abbas and Ezequiel Farrher and Elene Iordanishvili and Nino Kobalia and Krzysztof Dzieciol and Farida Grinberg and Nadim Jon Shah},
abstract={
In addition to cardiovascular risk factors, Type 2 diabetes mellitus (T2DM) is associated with microstructural, structural, functional and metabolic changes in the brain. Patients with T2DM tend to develop cognitive impairment and dementia. In this study, we report differences between groups of T2DM patients and age-matched healthy volunteers by comparing diffusion tensor and diffusion kurtosis metrics using the tract-based spatial statistics (TBSS) method. We found that all diffusivities are larger and the axonal water fraction is reduced in the T2DM group compared to the controls. This suggests presence of more water in the extra-axonal space.}
}
@inproceedings{ISMRM2018_3726,
annote={ISMRM2018_3726},
pages={3726},
file={ISMRM2018_3726.pdf:ISMRM2018_3726.pdf:PDF},
title={Gray matter cortical thickness changes in Hypothyroid patients: A study using high-resolution structural imaging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3726.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Mukesh Kumar and Poonam Rana and Pooja Rathore and Deepak Sharma and Prabhjot Kaur and Tarun Sekhri and Subash Khushu},
abstract={The aim of our study was to assess changes in cortical thickness, cortical area and cortical volume of gray matter (GM) for hypothyroid patients. We had acquired high-resolution 3D T1 weighted structural data for both control (24) and hypothyroid subjects (22). Reduced gray matter cortical thickness was observed in lateraloccipital cortex, postcentral gyrus, medialorbitofrontal cortex, lingual gyrus, superior and inferior parietal cortex in hypothyroid patients as compare to controls. These findings of reduced gray matter (CTh) suggest abated activities of motor, attention, working memory and executive cognitive function in hypothyroid patients.}
}
@inproceedings{ISMRM2018_3727,
annote={ISMRM2018_3727},
pages={3727},
file={ISMRM2018_3727.pdf:ISMRM2018_3727.pdf:PDF},
title={On the Importance of Using High-Resolution Atlases for Voxel-Based Morphometry of High-Resolution {MRI} Data: A Case-Control Study on Essential Tremor},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3727.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Eric M Cameron and Jonathan P Dyke and Elan D Louis and Ulrike Dydak},
abstract={The use of a high resolution atlas for segmentation and normalization greatly improves the accuracy of voxel-based morphometry analysis of magnetic resonance images. An adjusted method including the high resolution atlas was compared to the default method with the standard resolution atlas in a case-control study on essential tremor to demonstrate the impact of higher resolution segmentation. After multiple comparison correction using extent cluster thresholding, the adjusted method showed bilaterally consistent results, while the default method showed some false positive results in peripheral regions of the brain. A high resolution atlas should be used to segment equally high resolution images.}
}
@inproceedings{ISMRM2018_3728,
annote={ISMRM2018_3728},
pages={3728},
file={ISMRM2018_3728.pdf:ISMRM2018_3728.pdf:PDF},
title={Developmental alteration of mean diffusivity in striatum of transgenic Huntington’s disease monkey},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3728.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yuguang Meng and Jocelyne Bachevalier and Anthony W.S. Chan and Xiaodong Zhang},
abstract={Huntington Disease (HD) is a neurodegenerative disorder with a primary etiology of striatal pathology. Abnormal mean diffusivity changes have been seen previously in HD patients. However, it remains not fully understood how the diffusivity property of striatum evolves during the development of the disease. This study examined the progressive changes of striatum of rhesus monkey brains with HD gene mutation using diffusion tensor imaging (DTI) and it was found that there was significant MD difference from the control animals in striatum at very early age.}
}
@inproceedings{ISMRM2018_3729,
annote={ISMRM2018_3729},
pages={3729},
file={ISMRM2018_3729.pdf:ISMRM2018_3729.pdf:PDF},
title={Radiological Imaging of Brain Iron Deposits and T1 quantification feasibility using 3D {UTE} Cones.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3729.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Piotr Wielopolski and Elene vroegindeweij and Agnita Boon and Janneke Langendonk and Juan Antonio Hernandez-Tamames},
abstract={In this work, we demonstrate that 3D UTE cones enablesthe possibility of T1 contrast and T1 relaxometry of iron deposits in the brain. We present radiological images of brain iron and T1 quantification of iron deposits in a pathology with an exacerbated amount of iron in the brain. We demonstrate that even for conventional T2 and T2* mapping is challenging to obtain relaxometry. However, it is feasible for a 3D UTE cones sequence.}
}
@inproceedings{ISMRM2018_3730,
annote={ISMRM2018_3730},
pages={3730},
file={ISMRM2018_3730.pdf:ISMRM2018_3730.pdf:PDF},
title={Longitudinal Diffusion Tensor Imaging in the brain in Friedreich’s Ataxia: follow-up at 12 and 24 months},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3730.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Pierre-Gilles Henry and James Joers and Dinesh Deelchand and Diane Hutter and Christophe Lenglet},
abstract={We report 12-month and 24-month longitudinal diffusion tensor imaging (DTI) data in the brain of subjects with Friedreich’s ataxia (FRDA). Significant longitudinal changes were observed in several brain areas (including the corpus callosum, internal capsule and superior corona radiata) in a group of 13 patients over 24 months. Our data suggest that diffusion MRI of the brain could be useful to better understand the impact of FRDA on brain microstructure and connectivity and to assess the effect of potential treatments on neurodegeneration in upcoming clinical trials in FRDA.}
}
@inproceedings{ISMRM2018_3731,
annote={ISMRM2018_3731},
pages={3731},
file={ISMRM2018_3731.pdf:ISMRM2018_3731.pdf:PDF},
title={Magnetic susceptibility of the dentate in a longitudinal study of Friedreich ataxia},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3731.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Phillip G D Ward and Ian H Harding and Parnesh Raniga and Tom G Close and Louise A Corben and Martin B Delatycki and Monique R Stagnitti and Elsdon Storey and Nellie Georgiou-Karistianis and Gary F Egan},
abstract={We performed in-vivo measurements of the magnetic susceptibility in the dentate nucleus in individuals with Friedreich ataxia and healthy controls over a two-year longitudinal study using quantitative susceptibility mapping. The results show a significant susceptibility difference between individuals with Friedreich ataxia and control subjects and a strong correlation with disease severity in the Friedreich ataxia cohort. These findings may lead to the development of a sensitive biomarker of disease severity and progression in Friedreich ataxia.}
}
@inproceedings{ISMRM2018_3732,
annote={ISMRM2018_3732},
pages={3732},
file={ISMRM2018_3732.pdf:ISMRM2018_3732.pdf:PDF},
title={Delivery of m{HTT} to the rhesus macaque brain leads to a reduction in caudate volume in a new monkey model of Huntington’s disease},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3732.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Zheng Liu and Alison R. Weiss and Christopher D. Kroenke and Jodi L. McBride},
abstract={Huntington’s disease (HD) is a genetic, neurodegenerative disorder caused by CAG repeat expansion in mutant huntingtin gene (mHTT) on Chromosome 4 and is characterized by degeneration of several brain regions, with the caudate nucleus and the putamen being the most heavily affected. Structural MRI was used to investigate the longitudinal striatal atrophy in a new rhesus macaque HD model, especially the reduction of rostral caudate volume. According to the longitudinal volumetric analysis, the delivery of 82Q mHTT to rhesus macaque striatum leads to a significant reduction in caudate volume. However, no such significant differences following delivery of 16Q mHTT model was observed. These data indicate that viral delivery of 82Q mHTT serves as a nonhuman primate model of Huntinton’s disease that reproduces neuropathological characteristics of the disease.}
}
@inproceedings{ISMRM2018_3733,
annote={ISMRM2018_3733},
pages={3733},
file={ISMRM2018_3733.pdf:ISMRM2018_3733.pdf:PDF},
title={{MRI} Connectivity Impairment Associated with Timing of Seizure Recurrence After Surgery in Temporal Lobe Epilepsy},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3733.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Victoria L Morgan and Dario J Englot and Baxter P Rogers and Adam W Anderson and Bennett A Landman and Bassel Abou-Khalil},
abstract={Surgical resection of the seizure focus in the mesial temporal lobe is a common treatment of drug-resistant temporal lobe epilepsy (TLE) with an approximately 80\% success rate. Our previous work showed that presurgical MRI-based functional and structural network connectivity can identify those TLE patients with the most unfavorable seizure outcomes. The goal of this work was to increase specificity of our prediction by characterizing those with seizure free and favorable outcomes. The results suggest that when impairment in functional connectivity of the seizure propagation network extends to the contralateral hemisphere, patients will experience rare post-surgical seizures sooner.}
}
@inproceedings{ISMRM2018_3734,
annote={ISMRM2018_3734},
pages={3734},
file={ISMRM2018_3734.pdf:ISMRM2018_3734.pdf:PDF},
title={Vertex-based thalamus morphometry and tract-based spatial statistics of the white matter show differences between patients with chronic low back pain and fibromyalgia},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3734.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Huiling Peng and Alyssa Smith and Kelly Boland and Jason Craggs},
abstract={Chronic low back pain (CLBP) is now considered a disease of the central nervous system. Two-thirds of individuals with CLBP also have fibromyalgia (FM) which is a chronic pain syndrome characterized by widespread deep musculoskeletal pain and cognitive deficits. The aim of this study was to investigate gray and white matter changes between FM and CLBP groups using vertex analysis of thalamus and tract-based spatial statistics (TBSS). Significant surface depression was detected in right thalamus of patients with FM compare to CLBP. TBSS analysis showed significantly reduced FA in several white matter tracts of patients with FM compared to CLBP.}
}
@inproceedings{ISMRM2018_3735,
annote={ISMRM2018_3735},
pages={3735},
file={ISMRM2018_3735.pdf:ISMRM2018_3735.pdf:PDF},
title={The association between brain volumes and physical frailty in older individuals},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3735.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ilse Kant and Jeroen de Bresser and Simone van Montfort and Ellen Aarts and Ilona Bader and Yarit Wiggerts and Georg Winterer and Claudia Spies and Arjen Slooter and Jeroen Hendrikse},
abstract={Physical frailty develops with increasing age and is a chronic state of vulnerability that is associated with disability and cognitive decline. Few studies have assessed the underlying structural brain abnormalities of physical frailty. We therefore examined the association between brain volumes on MRI and physical frailty in a group of 214 non-demented elderly participants. Frail participants showed a lower total brain volume and a lower grey matter volume compared to pre-frail and non-frail participants. Furthermore, pre-frail participants showed more cortical infarcts compared to non-frail participants. These brain abnormalities could be the underlying substrate of the physical frailty phenotype.}
}
@inproceedings{ISMRM2018_3736,
annote={ISMRM2018_3736},
pages={3736},
file={ISMRM2018_3736.pdf:ISMRM2018_3736.pdf:PDF},
title={Changes in brain connectivity of the first-episode idiopathic epilepsy patients before and after treatment: A comparative study of resting-state f{MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3736.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Pengfei Qiao and Guang-ming Niu and Yang Gao and Lizhi Xie},
abstract={This study investigates the fractional amplitude of low frequency fluctuation (fALFF) of the first-episode complex partial seizures epilepsy patients before and after treatment by using resting state fMRI (rfMRI). It is found that fALFF can be used to detect interictal epileptiform change before and after treatment.}
}
@inproceedings{ISMRM2018_3737,
annote={ISMRM2018_3737},
pages={3737},
file={ISMRM2018_3737.pdf:ISMRM2018_3737.pdf:PDF},
title={Investigation of cognition associated cerebral perfusion changes in Alzheimer's disease and mild cognitive impairment using a novel 3D arterial spin labeling technique},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3737.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yong Zhang and Hua-Wei Lin and Bei Ding and Fu-Hua Yan and Bing Wu},
abstract={This preliminary study investigated cognition associated cerebral perfusion changes in Alzheimer’s disease (AD) and mild cognitive impairment (MCI) measured with a novel 3D arterial spin labeling technique. The voxel-wise regression analysis against MMSE scores was performed using whole brain CBF maps. Cognition associated CBF deficits in the hippocampus and insular cortex might cause the typical AD symptoms including memory loss and emotion issues. CBF decrease in MCI patients in the lingual gyrus could affect vision and wording functions. CBF increase in the frontal lobe might serve as an early indicator for high-level cognitive function disturbance.}
}
@inproceedings{ISMRM2018_3738,
annote={ISMRM2018_3738},
pages={3738},
file={ISMRM2018_3738.pdf:ISMRM2018_3738.pdf:PDF},
title={Multi-parametric {MRI} of the Proximal and Distal Nerves of the Leg: Longitudinal Findings in Patients with Inherited Neuropathies},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3738.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Michael Pridmore and Richard Dortch and Jun Li},
abstract={This project proposes a multi-parametric set of MRI tools for assaying human inherited neuropathies in vivo, with the longer-term goal of establishing biomarkers of disease progression for future clinical trials. Previous research shows magnetization transfer ratio (MTR) values, which assay myelin content changes from demyelination and axonal loss, relate to disability in neuropathy patients. Here, we proposed additional fat-water (Dixon) imaging to assay fat replacement following deinnervation. MTR/Dixon data were collected in the sciatic/tibial nerves in patients with primary dysmyelinating inherited neuropathies. Longitudinal results showed lower that MTR/Dixon were responsive to disease progression.}
}
@inproceedings{ISMRM2018_3739,
annote={ISMRM2018_3739},
pages={3739},
file={ISMRM2018_3739.pdf:ISMRM2018_3739.pdf:PDF},
title={Structural remodeling of the sciatic nerve differs between painful and painless diabetic polyneuropathy: an in vivo study using magnetic resonance neurography.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3739.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Johann Malte Enno Jende and Jan B Groener and Stefan Kopf and Tim Hilgenfeld and Sabine Heiland and Mirko Pham and Peter Nawroth and Martin Bendszus and Felix Tobias Kurz},
abstract={Diabetic polyneuropathy (DN) is one of the most severe complications of diabetes. It is yet uncertain why patients either suffer from painful (PDN) or painless (NPDN) diabetic polyneuropathy. We prospectively performed magnetic resonance neurography of the sciatic nerve in 120 patients suffering from DN of varying severity and correlated the results with clinical symptoms and electrophysiological data. We found a higher load of lesions to the sciatic nerve in PDN compared to PDN (p<0.0001), extending over longer distances (p<0.0001). This indicates that proximal nerve damage is one of the main contributors to the development of PDN.}
}
@inproceedings{ISMRM2018_3740,
annote={ISMRM2018_3740},
pages={3740},
file={ISMRM2018_3740.pdf:ISMRM2018_3740.pdf:PDF},
title={Quantitative Susceptibility Mapping of post-mortem {ALS} brains at 7T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3740.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Chaoyue Wang and Benjamin Tendler and Menuka Pallebage-Gamarallage and Olaf Ansorge and Ricarda AL Menke and Martin R Turner and Sean Foxley and Karla L Miller},
abstract={Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease of the motor system and its wider cortical connections. Progress in therapeutic development in ALS is compromised by a lack of specific biomarkers. In this work, we describe a platform for acquiring QSM data in post-mortem brains and propose a protocol for post-mortem QSM reconstruction. Preliminary results have shown that ALS brains had substantially greater mean susceptibility in motor cortex than control brains, which indicates that QSM has the potential to accurately quantify iron concentration and thus serve as an imaging biomarker for ALS.}
}
@inproceedings{ISMRM2018_3741,
annote={ISMRM2018_3741},
pages={3741},
file={ISMRM2018_3741.pdf:ISMRM2018_3741.pdf:PDF},
title={Diffusion Kurtosis Imaging of the Motor Cortex in Amyotrophic Lateral Sclerosis},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3741.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Thomas Welton and Fraser Callaghan and Jerome J Maller and Matthew Middione and R Marc Lebel and Ek T Tan and Dominic B Rowe and Ajit Shankar and Stuart M Grieve},
abstract={Amyotrophic lateral sclerosis (ALS) is characterised by degeneration of the motor neurons. Diffusion kurtosis imaging (DKI) may be a suitable biomarker for neuronal injury in ALS. We imaged 30 people with ALS and 63 controls with a 140-direction DKI protocol and explored group differences diffusion and kurtosis scalar values within the motor cortex. Our preliminary data show that significant microstructural changes are measurable by DKI in people with early ALS. DKI may represent a viable biomarker of early ALS progression.}
}
@inproceedings{ISMRM2018_3742,
annote={ISMRM2018_3742},
pages={3742},
file={ISMRM2018_3742.pdf:ISMRM2018_3742.pdf:PDF},
title={Initial Experience of Cerebral Quantitative Susceptibility Mapping in the {HIV} Neurocognitive Disorder},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3742.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Sara Marie Dupont and Yan Li and Ycheng Chen and Janine Lupo and Felicia Chow and Jared Narvid},
abstract={This study investigates the patterns of tissue susceptibility within brains of older HIV+ participants using quantitative susceptibility mapping (QSM) as marker of iron deposition in the brain. Four HIV+ participants and one healthy control were recruited and QSM and T1w (for cortical parcellation) data were acquired on a 3T MRI scanner. Comparison of QSM values by brain region for each HIV+ participant with the control shows a pattern of increased susceptibility in frontal regions, especially in the frontal medial and subcallosal cortices. Although these results warrant further investigation in a larger cohort, this is the first study investigating changes in QSM in the HIV+ population.}
}
@inproceedings{ISMRM2018_3743,
annote={ISMRM2018_3743},
pages={3743},
file={ISMRM2018_3743.pdf:ISMRM2018_3743.pdf:PDF},
title={The Abnormal Cerebral Perfusion Profile in older adults with {HIV}-Associated Neurocognitive Disorder: Discriminative Power of Arterial Spin Labelling {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3743.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Sara Marie Dupont and David McCoy and Andrew Callen and Duygu Tosun and Joanna Hellmuth and Victor Valcour and Jared Narvid},
abstract={This study aimed at evaluating the pattern of cerebral blood flow (CBF) abnormalities in older adults with HIV-associated neurocognitive disorder (HAND) compared to cognitively healthy controls. Pulsed ASL (for CBF quantification) and T1-weighted images (for registration to cortical parcellation atlas) were collected in a retrospective cohort of 19 HIV+ participants and 15 age and education matched controls. To investigate differences in CBF patterns between HIV+ and controls, CBF values were used to train generalized linear models (GLMnet) to predict patient diagnosis. Older HIV+ exhibited lower CBF values in the temporal and occipital lobes compared to controls suggesting a specific pattern of CBF in individuals aging with HAND.}
}
@inproceedings{ISMRM2018_3744,
annote={ISMRM2018_3744},
pages={3744},
file={ISMRM2018_3744.pdf:ISMRM2018_3744.pdf:PDF},
title={Structural connectivity alterations in amyotrophic lateral sclerosis are modulated by the topology of the anatomical brain connectome},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3744.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Silvia Basaia and Federica Agosta and Nilo Riva and Edoardo G. Spinelli and Yuri Falzone and Adriano Chiò and Andrea Falini and Giancarlo Comi and Massimo Filippi},
abstract={In this study, we used graph theory and connectomics to test whether the spatial patterning of structural brain alterations in amyotrophic lateral sclerosis (ALS) is modulated by the topology of the anatomical brain network. In the healthy subject connectome, brain regions of subsequent stages of ALS pathology are shown to be more closely interconnected (shorter topological distance) with the primary motor cortex (ALS epicenter) than regions of more distant stages. Altered structural connectivity was greater between closely connected regions. Axonal connections may influence the spatial spreading of pathology in ALS.
}
}
@inproceedings{ISMRM2018_3745,
annote={ISMRM2018_3745},
pages={3745},
file={ISMRM2018_3745.pdf:ISMRM2018_3745.pdf:PDF},
title={Evaluation of the Full Z Spectrum Obtained from Demented Patients},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3745.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Geon-Ho Jahng and Bo Guem Choi and Hak Young Rhee and Chang-Woo Ryu and Dal Mo Yang and Wook Jin},
abstract={To evaluate the characteristics of chemical exchange proton pools using a CEST MRI technique in dementia patients, 19 demented and 22 non-demented subjects were scanned a full Z spectrum data using a 3D GRASE sequence. The 6 pool maps with the Lorentzian fitting and MTR asymmetry map pool were calculated and compared between the two groups. The amide, amine, hydroxyl, DWS, NOE, MT and MTR asymmetry values at 1 ppm, 3ppm and 3.5 ppm were higher in the demented group than in the non-demented group.}
}
@inproceedings{ISMRM2018_3746,
annote={ISMRM2018_3746},
pages={3746},
file={ISMRM2018_3746.pdf:ISMRM2018_3746.pdf:PDF},
title={{MRI} based assessment of cerebrovascular pathology in Alzheimer’s disease},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3746.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ying Xia and Nawaf Yassi and Pierrick Bourgeat and Parnesh Raniga and Patricia Desmond and Jurgen Fripp and David Ames and Paul Maruff and Chris Fowler and Ralph Martins and Victor Villemagne and Collin Masters and Christopher Rowe and Olivier Salvado},
abstract={Cerebrovascular disease often coexists with Alzheimer’s disease (AD) and its contribution to the development of AD remains unclear. This study assessed cerebrovascular pathology in terms of brain infarction and white matter hyperintensities (WMH) in the AIBL study and investigated its impact on amyloid deposition. Our data revealed significantly greater WMH burden and higher prevalence of cerebrovascular pathology in AD patients. No correlation was found between amyloid load and WMH in either healthy controls, mild cognitive impairment or AD. Moreover, the presence of cerebrovascular pathology showed no association with amyloid deposition in subjects with or without AD.}
}
@inproceedings{ISMRM2018_3747,
annote={ISMRM2018_3747},
pages={3747},
file={ISMRM2018_3747.pdf:ISMRM2018_3747.pdf:PDF},
title={Assessment of different molecular iron forms in the brain tissue of Alzheimer patients},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3747.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Lucia Bossoni and Marjolein Bulk and Wico H. Breimer and Andrew G. Webb and Jelle Goeman and Martina Huber and Tjerk H. Oosterkamp and Louise van der Weerd},
abstract={Magnetic Resonance Imaging (MRI) has the potential to measure iron accumulation in the brain of Alzheimer patients. However, current MRI techniques cannot differentiate between different molecular iron forms. We have recently developed a combination of MRI, EPR and SQUID magnetometry, to quantify specific molecular iron forms in brain tissue. In this current study of AD patients and controlswe found significant differences in R
2*, ferritin concentration and magnetic moment of magnetite nanoparticles between patients (N=22) and controls (N=14). Additionally, we identified correlations between some iron forms.}
}
@inproceedings{ISMRM2018_3748,
annote={ISMRM2018_3748},
pages={3748},
file={ISMRM2018_3748.pdf:ISMRM2018_3748.pdf:PDF},
title={Oxygen extraction fraction is differentially affected in aging and Alzheimer’s disease: cross-sectional and longitudinal investigations in mice at 11.7T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3748.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Zhiliang Wei and Lin Chen and Zixuan Lin and Jiadi Xu and Siyuan Cheng and Zheyu Wang and Peter van Zijl and Hanzhang Lu},
abstract={Quantification of oxygen extraction fraction (OEF) is traditionally challenging and often requires the use of radiotracers or other invasive procedures, but has become feasible with recent advances in MR oximetry techniques. Here, we investigated the OEF in aging and Alzheimer’s disease (AD) with the T2-Relaxation-Under-Spin-Tagging (TRUST) technique. Based on the cross-sectional and longitudinal investigations, we demonstrated that normal aging and AD have different effects on brain OEF, which may reflect the dynamic nature of changes in brain energy homeostasis during these two processes. TRUST MRI may be a useful tool in elucidating physiological mechanisms of brain diseases in mouse models.}
}
@inproceedings{ISMRM2018_3749,
annote={ISMRM2018_3749},
pages={3749},
file={ISMRM2018_3749.pdf:ISMRM2018_3749.pdf:PDF},
title={The estimation of diagnostic accuracy of {FDG}-{PET}/{MR} imaging for Alzheimer's disease— simulation study using {ADNI}-data},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3749.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Tetsuro Sekine and Alfred Buck and Gaspar Delso and Edwin ter Voert and Martin W Huellner and Patrick Veit-Haibach and Geoffrey Warnock},
abstract={The purpose of this study was to estimate the impact of commercial MRAC on the evaluation of dementia, especially in Alzheimer’s disease (AD). We combined ADNI-data and patients data. We multiplied 14 error map derived from commercial Atlas-based MRAC method and each 203 ADNI data after the same nomalization and smoothing. To clarify the statement of prediction of AD, PET score was calculated by using PALZ. The accuracy, sensitivity and specificity for the discrimination of AD-patients from the normal control was not so impaired by MR-AC (Original vs. Error; 83.2\%, 83.3\% and 83.1\% vs. 81.3\% [range 77.6-83.2], 82.6\% [range 79.2-85.4\%,] and 80.3\% [range71.2-86.4\%]).}
}
@inproceedings{ISMRM2018_3750,
annote={ISMRM2018_3750},
pages={3750},
file={ISMRM2018_3750.pdf:ISMRM2018_3750.pdf:PDF},
title={In-vivo mapping of monoaminergic network disruption in Alzheimer’s disease: implications for neuropsychiatric symptoms},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3750.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Laura Serra and Marcello D'Amelio and Carlotta Di Domenico and Camillo Marra and Nicola Biagio Mercuri and Carlo Caltagirone and Mara Cercignani and Marco Bozzali},
abstract={Some recent animal models and neuropathological evidence highlighted the loss of noradrenergic neurons in the locus coeruleus and dopaminergic neurons in the ventral tegmental area (VTA) as important pathophysiological events in Alzheimer's disease. Here we use resting-state functional MRI to show reductions in VTA connectivity in patients with Alzheimer's disease and mild cognitive impairment, which are more prominent in patients with neuropsychiatric symptoms.}
}
@inproceedings{ISMRM2018_3751,
annote={ISMRM2018_3751},
pages={3751},
file={ISMRM2018_3751.pdf:ISMRM2018_3751.pdf:PDF},
title={Loss of Intra- and Inter-Network Resting State Functional Connectivity in Patients with Mild and Moderate Alzheimer’s Disease},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3751.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yiqiu Liu and Man Sun and Yuanyuan Chen and Xiuwei Fu and Tianyi Qian and Hongyan Ni},
abstract={This study aimed to investigate the differences in the alteration of the entire brain network functional connectivity of mild and moderate AD patients based on fMRI, taking the cerebellum network into consideration. There have seldom been reports regarding the cerebellum and cerebral connectivity alteration during the progression of clinical AD. Moreover, the cerebellum network functional connectivity is significantly changed in moderate AD and we further suspected that the cerebellum network is a pivotal one in the progression to the moderate AD stage.}
}
@inproceedings{ISMRM2018_3752,
annote={ISMRM2018_3752},
pages={3752},
file={ISMRM2018_3752.pdf:ISMRM2018_3752.pdf:PDF},
title={Apolipoprotein E e4 allele is associated with higher structural brain changes in patients with mild cognitive impairment},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3752.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Sheema Hashem and Santosh K Yadav and Asma Al-Sulaiti and Ajaz A Bhat and Tooba Ahmed and Deepak Kaura and Ari Borthakur and Mohammad Haris},
abstract={The aim of this study was to measure the difference in cortical thickness, subcortical volume and CSF biomarkers between MCI patients who carry or lack ApoE ε4 allele. High-resolution T1-weighted images were used for the measurement of cortical thickness and subcortical volume using FreeSurfer. MCI patients who carry ApoE ε4 showed significant reduction in cortical thickness and subcortical volume in multiple brain regions than non-carriers. This suggests that having an ApoE ε4 allele could be a risk factor for the larger tissue damage in the brain of MCI and these patients may have higher chance of developing Alzheimer’s or other dementia.}
}
@inproceedings{ISMRM2018_3753,
annote={ISMRM2018_3753},
pages={3753},
file={ISMRM2018_3753.pdf:ISMRM2018_3753.pdf:PDF},
title={White matter free water content at different stages of Alzheimer’s disease},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3753.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Matthieu Dumont and Koene R. A. Van Dijk and Felix C. Morency and Jean-Christophe Houde and Pierre-Marc Jodoin and Zhiyong Xie and Cici Bauer and Tarek A. Samad and Maxime Descoteaux and James A. Goodman},
abstract={Recent evidence shows that neuroinflammation plays a role in many neurological diseases including Alzheimer’s disease (AD) and that free water (FW) diffusion imaging can be sensitive to this phenomenon. We processed MRI data from the ADNIGO and ADNI2 databases with a state-of-the-art processing pipeline that uses T1 weighted (T1w), diffusion weighted (DW) and fluid-attenuated inversion recovery (FLAIR) scans to extract FW fractional volume in normal appearing white matter. We call this metric relative FW volume (rFW volume). We demonstrate for the first time that rFW volume in white matter is higher for subjects with greater cognitive impairments.}
}
@inproceedings{ISMRM2018_3754,
annote={ISMRM2018_3754},
pages={3754},
file={ISMRM2018_3754.pdf:ISMRM2018_3754.pdf:PDF},
title={Semiautomatic Quantification of Cortical Amyloid with 18F-florbetaben {PET}/{MRI} in Alzheimer's disease and Other Neurodegenerative Disorders},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3754.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={JeeYoung Kim and Audrey P. Fan and Fabiola Bezerra de Carvlho Macruz and Jia Guo and Athanasia Boumis and Michael Greicius and Sharon Sha and Minal Vasanawala and Michael Moseley and Michael Zeineh and Greg Zaharchuk},
abstract={Amyloid PET is a useful quantitative biomaker in patients with dementia. We compared cortical amyloid deposition in Alzheimer’s disease (AD), Parkinson’s disease (PD), mild cognitive impairment (MCI) and cognitively normal elderly subjects and correlated it with cortical CBF and volume using simultaneous 18F-florbetaben PET/MRI. Total cortical SUV is significantly higher in AD than PD and MCI. Precuneus, superior temporal and calcarine cortices were identified as significant regions on amyloid PET to discriminate between AD and other neurodegenerative diseases.}
}
@inproceedings{ISMRM2018_3755,
annote={ISMRM2018_3755},
pages={3755},
file={ISMRM2018_3755.pdf:ISMRM2018_3755.pdf:PDF},
title={Fixel-based fiber-specific analysis of white matter lesions in Binswanger disease},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3755.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Rajikha Raja and Josef Ling and Gary Rosenberg and Arvind Caprihan},
abstract={Binswanger's disease (BD) is a form of vascular dementia which is prevalent in older population. BD is characterized by the presence of white matter lesions due to injured small vessels in the brain. Magnetic resonance imaging findings related to BD reported large white matter lesions in FLAIR and high blood-brain barrier permeability in dynamic contrast enhanced MRI. Changes in water diffusion in white matter lesions and axonal damage were reported using diffusion tensor imaging metrics. While all the studies focused on exploring the voxel level measures as BD markers, we aimed to quantify the WM integrity through measures estimated for fibers within a voxel. In this study, we apply fixel-based analysis (FBA) to multi-shell diffusion data to evaluate the fiber specific measures such as fiber density (FD) and fiber cross-section (FC) in regions of white matter lesions in BD subjects and compared the measures with healthy controls. Reduced FD and FDC are revealed in areas of white matter lesions in BD subjects as compared to those in control group.}
}
@inproceedings{ISMRM2018_3756,
annote={ISMRM2018_3756},
pages={3756},
file={ISMRM2018_3756.pdf:ISMRM2018_3756.pdf:PDF},
title={Non-Invasive Imaging of Brain Clearance Pathways using Multiple Echo Time {ASL}: An Aquaporin-4 Study},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3756.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yolanda Ohene and Ian F Harrison and Payam Nahavandi and Ozama Ismail and Ole P Ottersen and Erlend A Nagelhus and David L Thomas and Mark F Lythgoe and Jack A Wells},
abstract={We have developed the first non-invasive technique that is able to detect changes in brain AQP4-mediated clearance pathways. Our multi-TE ASL technique measures the exchange of vascular water into cortical brain tissue of mouse brain. We report a significant increase in the cortical exchange time between WT (377 ± 89ms) and AQP4-deficient (536 ± 92ms) mice. While measured CBF, ADC and δ
a did not detect differences, suggesting preserved haemodynamic and energetics between groups. This highlights the novelty of the technique being targeted method to assess water transport in brain clearance pathways, to help better understand neurodegenerative diseases.}
}
@inproceedings{ISMRM2018_3757,
annote={ISMRM2018_3757},
pages={3757},
file={ISMRM2018_3757.pdf:ISMRM2018_3757.pdf:PDF},
title={What reference for reference ranges? How scanner and subject data heterogeneity impact {MR} hippocampal volumetry statistics in Alzheimer’s Disease},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3757.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jonas Richiardi and Bénédicte Maréchal and Alexis Roche and Reto Meuli and Tobias Kober},
abstract={The volume of specific brain structures is of clinical interest in many brain diseases. By using a volumetric reference range for healthy subjects, radiologists can contribute to refining diagnosis. However, both scanner and subject characteristics impact the construction and use of these reference ranges. Using a diverse dataset with 80 MRI scanners and 302 subjects, we show Alzheimer’s disease detection from hippocampal volume is robust to mismatch between training (development) and testing (deployment) environments despite showing some influence, but that estimates of atrophy rates can vary considerably depending on the training set used. Radiologists should interpret volumetry statistical results accordingly.}
}
@inproceedings{ISMRM2018_3758,
annote={ISMRM2018_3758},
pages={3758},
file={ISMRM2018_3758.pdf:ISMRM2018_3758.pdf:PDF},
title={Automatic classification of patients with Alzheimer’s disease ({AD}) and mild cognitive impairment ({MCI}) who will convert to {AD} using deep neural networks},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3758.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Federica Agosta and Silvia Basaia and Luca Wagner and Giuseppe Magnani and Massimo Filippi},
abstract={We built and validated a deep learning algorithm that predicts the individual diagnosis of Alzheimer’s disease (AD) and the development of AD in mild cognitive impairment (MCI) patients based on a single cross-sectional brain structural MRI scan. The deep neural network (DNN) procedure discriminated AD and heathy controls with an accuracy up to 98\% and MCI converters and MCI stable with an accuracy up to 75\%. DNNs provide a powerful tool for the automatic classification of AD and MCI prognosis.}
}
@inproceedings{ISMRM2018_3759,
annote={ISMRM2018_3759},
pages={3759},
file={ISMRM2018_3759.pdf:ISMRM2018_3759.pdf:PDF},
title={Quasi-Periodic patterns contribute to rsf{MRI} functional connectivity in a mouse model of Alzheimer’s disease},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3759.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Michaël Eddy F Belloy and Disha Shah and Behnaz Yousefi and Anzar Abbas and Amrit Kayshap and Annemie van Der Linden and Georgios A. Keliris and Shella Keilholz and Marleen Verhoye},
abstract={We show the detection of Quasi-Periodic patterns (QPPs) in a mouse model of Alzheimer’s disease and illustrate that QPP detection was altered between wild-type and transgenic animals. We show that QPPs contributed to BOLD functional connectivity (FC) within groups and to FC differences between groups. Regression of QPPs diminished FC in co-active regions within the QPP, while anti-correlated regions became correlated. Regression of similar QPPs in wild-type and transgenic animals altered between-group FC differences by 30-50\%. These findings shed light on how QPPs contribute to FC and are promising for the application of QPPs as a new pre-clinical tool.}
}
@inproceedings{ISMRM2018_3760,
annote={ISMRM2018_3760},
pages={3760},
file={ISMRM2018_3760.pdf:ISMRM2018_3760.pdf:PDF},
title={Evaluate the Methanol-induced Alzheimer’s Disease Monkey Model by Resting-state Functional {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3760.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yin-Chieh Liu and Chaoyang Tian and Ssu-Ju Li and Xudong Zhao and Ting-Chun Lin and Jianjun Li and Ching-Wen Chang and Kaimin Wang and Yingshan Yang and Yu-Chun Lo and YuanYe Ma and You-Yin Chen* and Feng Chen* and Hsin-Yi Lai*},
abstract={Alzheimer’s disease (AD) is the most comment neurodegenerative disorder that results in the irreversible loss of neurons, especially in the cortex and hippocampus. The aim of this study is to evaluate the changes of brain functional connectivity in methanol-induced AD monkey. To find the corresponding response areas of AD, five brain regions defined by independent component analysis (ICA) were analyzed using seed-based correlation analysis (SCA). Results of resting-sate fMRI showed that the AD Monkey presented abnormal functional connectivity in anterior cingulate cortex (ACC), primary visual cortex (V1) and ventrolateral prefrontal cortex (VLPFC), those were also shown in AD patient.}
}
@inproceedings{ISMRM2018_3761,
annote={ISMRM2018_3761},
pages={3761},
file={ISMRM2018_3761.pdf:ISMRM2018_3761.pdf:PDF},
title={Assessment of cerebrovascular alterations in Alzheimer’s disease with simultaneous multislice Look-Locker arterial spin labeling},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3761.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Tae Kim and Oscar L Lopez and James T Becker},
abstract={The ASL dynamics, the transit time to arterial and capillary, CBVa and CBF, were measured in control and mild cognitive impairment subjects to access cerebrovascular alteration in AD progression. The MCI subjects had prolonged transit time, lower CBVa and CBF in comparison to control subjects. Detailed aseesements of cerebrovascular alterations can provide better characterization of AD pathophysiology.}
}
@inproceedings{ISMRM2018_3762,
annote={ISMRM2018_3762},
pages={3762},
file={ISMRM2018_3762.pdf:ISMRM2018_3762.pdf:PDF},
title={Bilateral salpingo-oophorectomy prior to natural menopause is associated with Alzheimer’s disease-like reductions in gray and white matter},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3762.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Suzanne T Witt and Åsa Rydmark Kersley and Elisabet Classon and Nina Lykke and Magrit Shildrick and Cecilia Åsberg and Cheryl Grady and Elvar Theordorsson and Jan Ernerudh and Elisabeth Åvall Lundqvist and Preben Kjølhede and Gillian Einstein},
abstract={Women with Breast Cancer Gene mutations (BRCAm) are recommended to undergo prophylactic bilateral salpingo-oophorectomy prior to natural menopause (PNM-BSO) in order to reduce the risk of ovarian cancer. This surgery is associated with an increased risk of developing Alzheimer's disease (AD). In comparison with healthy women, BRCAm women who had undergone PNM-BSO exhibited decreased gray matter volume across frontal and medial-temporal regions, as measured using the quantitative QRAPMASTER sequence. These regions included many previously linked with AD including, parahippocampal gyrus, cingulate cortex and inferior temporal gyrus. White matter reductions were only observed in a limited number of superior longitudinal tracts.}
}
@inproceedings{ISMRM2018_3763,
annote={ISMRM2018_3763},
pages={3763},
file={ISMRM2018_3763.pdf:ISMRM2018_3763.pdf:PDF},
title={Deep Learning-based {MRI} Image Analysis for the Prediction of Conversion from Mild Cognitive Impairment to Alzheimer's Disease},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3763.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Weiming Lin and Min Du and Di Guo and Xiaofeng Du and Yonggui Yang and Gang Guo and Xiaobo Qu},
abstract={Accurate prediction of the conversion from mild cognitive impairment (MCI) to Alzheimer’s disease (AD) is critically important to slow down the progression to AD with early clinical trials. In this work, this prediction for 3 years is conducted on MRI images shared in Alzheimer’s Disease Neuroimaging Initiative (ADNI) dataset. Two powerful image analysis tools, including convolutional neural networks in deep learning and FreeSurfer in brain MRI analysis, are introduced to learn image features which are used for further classification. Cross validation results demonstrate that the proposed approach achieves more accurate and robust prediction comparing with the state-of-the-art grading biomarker method.}
}
@inproceedings{ISMRM2018_3764,
annote={ISMRM2018_3764},
pages={3764},
file={ISMRM2018_3764.pdf:ISMRM2018_3764.pdf:PDF},
title={Correlation between Apparent Diffusion Coefficient at Ultrahigh b-values and cognitive impairment: a pilot study in early stage Alzheimer’s disease},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3764.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Qiong Ye and Zhenhua Zhang and Caiyun Wen and Zhao Zhang and Jiance Li},
abstract={Non-Gaussian diffusion showed the potential to advance the understanding of microstructure alternation in Alzheimer’s disease (AD). Apparent Diffusion Coefficient at Ultrahigh b-values (ADC_uh) demonstrated improved sensitivity to white matter degeneration in AD. In this study we compared the quantitative change of diffusion characteristics including conventional ADC, Diffusion Kurtosis Imaging (DKI) and ADC_uh. Moreover the correlation between diffusion characteristic and cognitive impairment was investigated. The results of this pilot study showed a close link between ADC_uh in left thalamus and cognitive impairment in AD patients. But further study with larger sample size is required to draw a clear conclusion.}
}
@inproceedings{ISMRM2018_3765,
annote={ISMRM2018_3765},
pages={3765},
file={ISMRM2018_3765.pdf:ISMRM2018_3765.pdf:PDF},
title={The Application of {NODDI} in Characterizing Brain Microstructural Changes in Type 2 Diabetes with Cognitive Impairment},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3765.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ying Xiong and Qiang Zhang and Yang Fan and Wenzhen Zhu},
abstract={This study aims to investigate brain microstructural changes in white-matter and gray-matter of type 2 diabetes mellitus(T2DM) patients using the NODDI model. Thirty-three T2DM patients were divided into two sub-groups (impaired and normal cognition), together with ten healthy controls, were imaged at a 3T scanner. It was found that the T2DM patients with cognitive impairment had a lower ICVF value compared to healthy controls in WM regions and the thalamus. Decreased ICVF values in the genu of corpus callosum were correlated with HbA1c level. The NODDI model shows potential feasibility in characterizing brain microstructural alterations for patients with T2DM.}
}
@inproceedings{ISMRM2018_3766,
annote={ISMRM2018_3766},
pages={3766},
file={ISMRM2018_3766.pdf:ISMRM2018_3766.pdf:PDF},
title={Subregional structural alterations in deep gray matter structures in alcohol-dependent patients},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3766.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Hyeon-Man Baek and Young-Tae Kim and Jae-Hyuk Shim},
abstract={The aim of this study was to investigate whether the volumes of subcortical gray matter structures in alcohol-dependent patients (ADP) are different and to localize the surface morphometric changes of these subcortical structures. Compared with healthy controls (HC), we found that the bilateral Accu, Hipp, Puta and Thal showed significant atrophy in ADP. We also revealed that vertex analysis directly can measure localized changes in brain structures that showed significant volumetric change. It might have potential to precisely detect regional alterations of the subcortical gray matter structures.}
}
@inproceedings{ISMRM2018_3767,
annote={ISMRM2018_3767},
pages={3767},
file={ISMRM2018_3767.pdf:ISMRM2018_3767.pdf:PDF},
title={Brain Structural Connectome Accurately Classifies Alzheimer’s Disease Related Dementia},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3767.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jiook Cha and Yun Wang and Allen Liu and Jonathan Posner and Jong-Hun Kim and Shinjae Yoo and Hyoung-Seop Kim},
abstract={There is an urgent, unmet need for biomarkers of risk for Alzheimer’s disease related dementia (ADRD) suitable for routine examination in naïve patients. Studies suggest MRI-derived brain connectome may contain salient information about brain health status. However, it has yet to be tested in sufficiently large samples whether connectome can be used to predict reliably diagnosis of ADRD. Here we performed high-throughput computational analysis using structure and diffusion MRI in a clinical cohort (N=211) to estimate morphometry and connectome. Our results show potential utility of data-driven machine learning models using large-scale MRI-derived brain phenotypes in classifying ADRD, particularly structural connectome.
}
}
@inproceedings{ISMRM2018_3768,
annote={ISMRM2018_3768},
pages={3768},
file={ISMRM2018_3768.pdf:ISMRM2018_3768.pdf:PDF},
title={{MR} Spectroscopy Biomarker Discovery Algorithms ({MBDA}) to Discriminate {PTSD} from Blast Exposure and Healthy Controls},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3768.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Nathan Tosh and Laura Mariano and Scott Quadrelli and Graham Galloway and Valerie Graves and Aaron Urquhart and Peter Malycha and Katie Trickey and Lisa Rich and Rosanna Tremewan and John Irvine and Carolyn Mountford},
abstract={Single Voxel Point RESolved Spectroscopy (PRESS) was used to obtain neuro-metabolite and lipid levels from the Posterior Cingulate Gyrus (PCG) of 4 cohorts – Control, Civilian PTSD, Artillery and Close Combat soldiers. Using a wavelet based statistical analysis approach classifiers were developed to objectively diagnose and monitor neuro-deregulation associated with PTSD and blast injury to artillery and to close combat soldiers.}
}
@inproceedings{ISMRM2018_3769,
annote={ISMRM2018_3769},
pages={3769},
file={ISMRM2018_3769.pdf:ISMRM2018_3769.pdf:PDF},
title={{ADHD} and stimulant medication disrupt the temporal lag structure within default mode and salience networks},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3769.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Charlotte Clarke and Arjun Sethi and Mara Cercignani and Neil Harrison},
abstract={Attention Deficit Hyperactivity Disorder (ADHD) is a neurodevelopmental disorder that has been associated with reduced Default Mode (DMN) (precuneus) and salience network (Anterior Cingulate) activity in conventional resting-state fMRI studies (rs-fMRI). However, these studies ignore the significant temporal structure in these data. Thirty ADHD patients and 30 matched controls underwent rs-fMRI on two occasions, 90-minutes after blindly administered stimulant medication and placebo. Using a novel ‘lag-thread’ analysis we demonstrate faster recruitment of the precuneus in ADHD which additionally correlated with severity of inattention. Stimulants slowed ACC recruitment, together suggesting potential importance of temporal activation of these regions in ADHD.}
}
@inproceedings{ISMRM2018_3770,
annote={ISMRM2018_3770},
pages={3770},
file={ISMRM2018_3770.pdf:ISMRM2018_3770.pdf:PDF},
title={{BMI} correlates with tissue stiffness in deep gray matter regions controlling eating behavior},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3770.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Stefan Hetzer and Martin Weygandt and Sebastian Hirsch and Jürgen Braun and Ingolf Sack},
abstract={Cerebral MR elastography was applied to a group of healthy male subjects in the normal weight range up to overweight to explore a potential relationship between the in vivo mechanical properties of brain tissue and body-mass index (BMI). We observed a highly significant negative correlation between tissue stiffness and BMI in the globus pallidus and putamen – two regions identified in the literature as being linked to eating behaviour – while the stiffness of other brain regions did not correlate with BMI. This is the first report on in vivo mechanical properties of brain tissue related to BMI.}
}
@inproceedings{ISMRM2018_3771,
annote={ISMRM2018_3771},
pages={3771},
file={ISMRM2018_3771.pdf:ISMRM2018_3771.pdf:PDF},
title={Fluid and White Matter Suppression sequence for detecting epileptogenic zones of focal cortical dysplasia},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3771.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Xin Chen and Tianyi Qian and Tobias Kober and Nan Chen and Kuncheng Li},
abstract={The aim of this study was to evaluate a novel sequence, called the fluid and white matter suppression (FLAWS) sequence, for detecting focal cortical dysplasia (FCD) lesions. FLAWS provides two sets of 3D contrast images from one acquisition and subsequently calculates another set of images that can suppress the signal from both the cerebral spinal fluid and white matter. The detection rate of the FCD lesions on FLAWS was higher than on the conventional 2D MR scan and 3D fluid-attenuated inversion recovery scan. Additionally, the transmantle sign, which is widely believed to be specific for FCD type II, could also be observed in FCD type I on the FLAWS images.}
}
@inproceedings{ISMRM2018_3772,
annote={ISMRM2018_3772},
pages={3772},
file={ISMRM2018_3772.pdf:ISMRM2018_3772.pdf:PDF},
title={Cortical Cerebral Blood Flow in Aging: Effects of Haematocrit, Sex and Ethnicity.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3772.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Lorna A. Smith and Andrew Melbourne and David Owen and M. Jorge Cardoso and Carole H. Sudre and Therese Tillin and Magdalena Sokolska and David Atkinson and Nish Chaturvedi and Sebastien Ourselin and Alun D. Hughes and Frederik Barkhof and H. R. Jager},
abstract={Cerebral blood flow (CBF) estimates using arterial spin labelling (ASL) show unexplained variability in older populations. We studied the impact of haematocrit (Hct) on CBF quantification in a tri-ethnic elderly population cohort. Hct was measured from blood samples and pseudo-continuous ASL performed on 3T MR. CBF was estimated using a fixed value of 43.5\% (model 1) and individually measured Hct (model 2) to calculate the longitudinal relaxation time of blood in simplified Buxton equations. CBF estimates using individual Hct were lower than CBF estimates using a mean Hct in all ethnic and sex categories except white European men.}
}
@inproceedings{ISMRM2018_3773,
annote={ISMRM2018_3773},
pages={3773},
file={ISMRM2018_3773.pdf:ISMRM2018_3773.pdf:PDF},
title={Predictive value of {QSM} for hippocampal atrophy in pre-clinical Alzheimer’s disease},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3773.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Amir Fazlollahi and Scott Ayton and Ibrahima Diouf and Pierrick Bourgeat and Vincent Dore and Parnesh Raniga and Jurgen Fripp and Patricia Desmond and David Ames and Paul Maruff and Ralph Martins and Chris Fowler and Roger Ordidge and Colin Masters and Christopher Rowe and Victor Villemagne and Ashley Bush and Olivier Salvado and on behalf of the Australian Imaging Biomarkers and Lifestyle (AIBL) Research Group},
abstract={One-third of cognitively normal people over the age of 65 exhibit β-amyloid plaques, a defining pathology of Alzheimer’s disease. The hippocampus also undergoes early and pronounced neurodegeneration in Alzheimer’s disease, which underlies the memory impairment. Cognitively normal people with high β-amyloid pathology are at risk of hippocampal neurodegeneration, but the rate of decline is variable between subjects. Here, we investigate whether the iron load of the hippocampus can be used to stratify risk for future hippocampal atrophy in cognitively normal people with and without β-amyloid. We applied Quantitative Susceptibility Mapping (QSM), a relatively new MRI modality that is sensitive to tissue iron levels, to 70 cognitively normal people who also had a PET scan for β-amyloid and were monitored for brain volume changes in MRI scans performed every 1.5 years for up to 7.5 years. We found that QSM of the hippocampus was strongly predictive of future atrophy of this region in cognitively normal subjects who had high β-amyloid pathology (P=2.3x10-6), but not in cognitively normal subjects with low pathology. These data support a role for iron in contributing to neurodegeneration in Alzheimer’s disease and QSM in combination of β-amyloid PET scans could be used to stratify patients at risk for cognitive decline in the pre-symptomatic phase.}
}
@inproceedings{ISMRM2018_3774,
annote={ISMRM2018_3774},
pages={3774},
file={ISMRM2018_3774.pdf:ISMRM2018_3774.pdf:PDF},
title={Biomarkers of dynamic energy metabolism in Huntington disease},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3774.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Isaac Mawusi Adanyeguh and Francesca Branzoli and Marie-Pierre Luton and Ben Cassidy and Emmanuel Brouillet and Caroline Rae and Pierre-Gilles Henry and Fanny Mochel},
abstract={Huntington disease (HD) is a dominantly inherited neurodegenerative disease characterized by involuntary abnormal movements, cognitive and psychiatric symptoms. Evidence suggests that energy deficit plays a critical role in the disease pathophysiology. There is however a lack of robust biomarkers for testing therapeutic strategies targeting brain energy metabolism. This study aims to measure dynamic parameters of brain energy metabolism and identify novel functional biomarkers of for use in therapeutic trials in HD. This study showed altered creatine kinase rate in patients with HD as well as altered diffusion rates of several metabolites in the corpus callosum of patients with HD.}
}
@inproceedings{ISMRM2018_3775,
annote={ISMRM2018_3775},
pages={3775},
file={ISMRM2018_3775.pdf:ISMRM2018_3775.pdf:PDF},
title={Pitfall of synthetic {MRI}: Effect of gadolinium on the estimation of brain tissue volumes and myelin based on rapid simultaneous relaxometry},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3775.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Tomoko Maekawa and Akifumi Hagiwara and Masaaki Hori and Koji Kamagata and Christina Andica and Takuya Haruyama and Kanako Sato and Saori Koshino and Ryusuke Irie and Akihiko Wada and Shigeki Aoki},
abstract={We investigated the effect of gadolinium on the automatic tissue and myelin volumetry using synthetic MRI. 17 patients with metastases and 19 patients without metastasis were retrospectively analyzed before and after administration of gadolinium. After gadolinium administration, white matter volume (ml), non-white matter/gray matter/cerebrospinal fluid volume (ml), myelin volume (ml) and myelin volume/brain parenchymal volume (\%) were significantly increased, whereas gray matter volume (ml), cerebrospinal fluid volume (ml), brain parenchymal volume (ml) and intracranial volume (ml) were significantly decreased regardless of metastasis. The gadolinium had significant effects on the automatic calculation of tissue and myelin volumes estimated by synthetic MRI.}
}
@inproceedings{ISMRM2018_3776,
annote={ISMRM2018_3776},
pages={3776},
file={ISMRM2018_3776.pdf:ISMRM2018_3776.pdf:PDF},
title={Neuro-anatomical changes in the early blind, late blind during critical developmental time: Voxel Based Morphometry study},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3776.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ankeeta . Ankeeta and Senthil S Kumaran and Rohit Saxena and N R Jagannathan},
abstract={In the early blind individuals, the white matter plasticity during the critical developmental period may compensate for the impairment resulting from the de-afferentation of the visual information that may explain for the early blind subjects show fewer regions with white matter impairments relative to the late blind}
}
@inproceedings{ISMRM2018_3777,
annote={ISMRM2018_3777},
pages={3777},
file={ISMRM2018_3777.pdf:ISMRM2018_3777.pdf:PDF},
title={Increased Deposition of Iron in Deep Cerebral Gray Matter Structures in Hemodialysis Patients: A Longitudinal, Susceptibility-Weighted Image Mapping Study},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3777.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Chao Chai and Saifeng Liu and Huiying Wang and Jinping Li and Tianyi Qian and E. Mark Haacke and Shuang Xia and Wen Shen},
abstract={The aim of this study was to explore the changes in abnormal iron deposition in hemodialysis patients by longitudinal follow-up MR exam with susceptibility-weighted image mapping (SWIM). SWIM was reconstructed from the magnitude and phase data of SWI to quantify the susceptibility of deep gray matter nuclei in patients with a baseline examination and follow-up examination and in healthy controls. The results suggest that iron deposition in the gray matter nuclei in patients increased over time and this process may be a risk factor for neurocognitive dysfunction. The independent risk factors for abnormal iron deposition included the follow-up interval, creatinine and abnormal calcium-phosphorus metabolism.}
}
@inproceedings{ISMRM2018_3778,
annote={ISMRM2018_3778},
pages={3778},
file={ISMRM2018_3778.pdf:ISMRM2018_3778.pdf:PDF},
title={Assessment of white matter de-differentiation in mild cognitive impairment using tract covariance matrix derived from diffusion spectrum imaging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3778.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Tao-Han Hung and Yung-Chin Hsu and Yu-Ling Chang and Isaac Wen-Yih Tseng},
abstract={In this study, we compared the degree of white matter de-differentiation between the patients with mild cognitive impairment (MCI) and normal-aging population using diffusion spectrum imaging (DSI) and whole brain tract-based automatic analysis (TBAA). The degree of de-differentiation, defined as the global level of generalized fractional anisotropy (GFA) covariance between each white matter tract, was found to be significantly higher in the MCI group, as revealed by two-sample T test of partial correlation matrices of the two subject groups. Further analysis showed that covariance was higher among projection tracts.}
}
@inproceedings{ISMRM2018_3779,
annote={ISMRM2018_3779},
pages={3779},
file={ISMRM2018_3779.pdf:ISMRM2018_3779.pdf:PDF},
title={Altered Hippocampal Structure and Functional Connectivity Associated with Memory Impairment in Patients with End-stage Renal Disease},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3779.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Xueying Ma and Dun Ding and Peng Li and Pan Zhang and Ming Zhang},
abstract={Memory impairment was common among ESRD patients, but the physiopathologic mechanisms were largely unclear. Hippocampus and prefrontal cortex played an important role in the human memory. Here we analyzed the structurre and functional connectivity of hippocampus and its correlation with memory scores (AVLT-H). We found that the hippocampal volume and FC between the rostral/caudal hippocampi and ventrolateral prefrontal cortex, dorsolateral prefrontal cortex as well as middle temporal gyrus. Correlations were found between hippocampal changes and memory impairment. Our study indicated that the hippocampus should be taken into consideration in the further mechanism study of neurol damage in ESRD patients.}
}
@inproceedings{ISMRM2018_3780,
annote={ISMRM2018_3780},
pages={3780},
file={ISMRM2018_3780.pdf:ISMRM2018_3780.pdf:PDF},
title={In-vivo Quantitative Structural Imaging of the Superior Colliculus at 9.4T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3780.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Joana Loureiro and Marc Himmelbach and Thomas Ethofer and Rolf Pohmann and Pascal Martin and Jonas Bause and Klaus Scheffler and Gisela E Hagberg},
abstract={We investigated the possibility to observe the anatomical details of the superior colliculus (SC), a layered structure located on the tectum of the midbrain, by in vivo MRI at 9.4T. Through image analysis in native space, several brain structures of the mid brain could be identified. The signal variation of all imaging modalities (T1, R2* and QSM) along and across the superior colliculus consistently highlighted the deep white layer VII, adjacent to the periaqueductal grey; the myelinated fibres in the superficial optic layer (layer III) and an iron-rich layer attributed to the intermediate grey layer (IV).}
}
@inproceedings{ISMRM2018_3781,
annote={ISMRM2018_3781},
pages={3781},
file={ISMRM2018_3781.pdf:ISMRM2018_3781.pdf:PDF},
title={White matter fibre tract changes in patients treated with {MR} imaging-guided focused ultrasound are associated with lesion location and clinical outcome},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3781.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Christian Thaler and Qiyuan Tian and Max Wintermark and Pejman Ghanouni and Casey H. Halpern and Jamie M. Henderson and Raag D. Airan and Michael Zeineh and Kim Butts Pauly and Jennifer A. McNab},
abstract={DTI is sensitive to tract-specific FA changes and thereby can be used to inform on therapeutic mechanisms and optimal targeting strategies for MRI-guided high intensity–focused ultrasound. Here, we used probablilistic tractography to investigate white matter fibre tract changes in essential tremor patients treated with MRIgHIFU. On the treated side, a significant decrease in FA was detected in the tracts projecting between the thalamus and motor cortex and between the dentate nucleus and the thalamus (i.e. the dentato-rubro-thalamic tract). These decreases in FA were correlated with the degree of tract-lesion overlap. Additionally, the post-treatment FA decrease in the tracts projecting between the thalamus and the motor cortex were positively correlated with clinical improvement. Interestingly, tract changes were also observed in the medial lemniscus of the contralesional side, possibly indicating global changes in brain connectivity.}
}
@inproceedings{ISMRM2018_3782,
annote={ISMRM2018_3782},
pages={3782},
file={ISMRM2018_3782.pdf:ISMRM2018_3782.pdf:PDF},
title={Associations between tissue sodium concentration, age and cross-sectional area in the healthy spinal cord},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3782.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Bhavana Shantilal Solanky and Ferran Prados and Marios C Yiannakas and Vanessa Bassan and Baris Kanber and Sebastien Ourselin and Olga Ciccarelli and Claudia Angela Gandini Wheeler-Kingshott},
abstract={Tissue sodium concentration has recently come into the spotlight for a number of neurological conditions, given its potential role in neurodegeneration and due to the advances in MRI technology. This has led to many studies in the brain, but there is a shortage of studies characterising sodium in the spinal cord. Here we use
23Na-MRS to measure sodium in the healthy spinal cord and look at the association between tissue sodium concentrations with age and spinal cord cross sectional area.}
}
@inproceedings{ISMRM2018_3783,
annote={ISMRM2018_3783},
pages={3783},
file={ISMRM2018_3783.pdf:ISMRM2018_3783.pdf:PDF},
title={White matter microstructural maturation in adolescent American Football athletes is affected by history of sport-participation and concussion},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3783.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yukai Zou and Ikbeom Jang and Nicole Vike and Diana Svaldi and Larry Leverenz and Eric Nauman and Thomas Talavage and Joseph Rispoli},
abstract={Concussion is a biomechanically induced brain injury that causes mental health concern for adolescent collision-sport athletes, whose brains are still developing and maturing. These athletes normally continue participating in collision events, regardless of history of concussion and risk for future concussion. Using diffusion tensor imaging, we investigated 93 asymptomatic adolescent athletes who participate in high school American Football. Per developmental expectations, we typically observed increasing fractional anisotropy or decreasing mean diffusivity with increasing years of high school experience, but prior history of concussion reversed this trend in a number of brain regions.}
}
@inproceedings{ISMRM2018_3784,
annote={ISMRM2018_3784},
pages={3784},
file={ISMRM2018_3784.pdf:ISMRM2018_3784.pdf:PDF},
title={Development and Evaluation of a contrast optimized 3D {SHINKEI} {MR} Neurography on patients with Brachial plexus injuries at 1.5T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3784.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Prashant Prabhakaran Nair and Rajagopal Kadavigere and Yogesh Kannan Mariappan and Samir Mustafa Paruthikunnan and Narayana Krishna Rolla and Indrajit Saha},
abstract={The objective of this work is to optimize the 3D nerve-SHeath signal increased with INKed rest-tissue RARE Imaging (SHINKEI) sequence for the best nerve-muscle T2 contrast in 1.5T and evaluate the clinical feasibility of this optimized sequence in 24 patients with brachial plexus injuries. Based on the evaluation by two experienced radiologists and the comparison to surgical observations, the optimized SHINKEI sequence performed better than fat suppressed TSE (STIR TSE) and Diffusion Weighted Imaging with Background Suppression (DWIBS) sequences that are currently widely used in the clinical protocols}
}
@inproceedings{ISMRM2018_3785,
annote={ISMRM2018_3785},
pages={3785},
file={ISMRM2018_3785.pdf:ISMRM2018_3785.pdf:PDF},
title={Melanopsin retinal ganglion cells in {LHON} patients: an f{MRI} study of brain activations under monochromatic light stimulation},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3785.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Stefania Evangelisti and Claudia Testa and Chiara La Morgia and Gilles Vandewalle and Claudio Bianchini and David Neil Manners and Paola Fantazzini and Michele Carbonelli and Alfredo Sadun and Caterina Tonon and Valerio Carelli and Raffaele Lodi},
abstract={We combined light stimulation and fMRI to investigate the contribution of melanopsin-expressing retinal ganglion cells (mRGCs) to visual and non-visual processes in Leber Hereditary Optic Neuropathy (LHON) paradigm of retinal degeneration . Monochromatic visual simulation showed a stronger effect in LHON visual cortex for blue vs red light with relatively long stimuli, supporting the hypothesis of a role for melanopsin in visual processes. When light was combined with a working memory task, blue light modulation of cognitive brain response was maintained in LHON; indeed the effect was stronger than in healthy subjects, probably because of the higher mRGCs/RGCs ratio in LHON retinas.}
}
@inproceedings{ISMRM2018_3786,
annote={ISMRM2018_3786},
pages={3786},
file={ISMRM2018_3786.pdf:ISMRM2018_3786.pdf:PDF},
title={Quantitative Dynamic Susceptibility Contrasted Perfusion in Differential Diagnosis of Recurrence and Radionecrosis for Brain Metastases after Stereotactic Radiotherapy},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3786.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Bao Wang and Tianyi Qian and Bin Zhao and Yingchao Liu and Na Sun},
abstract={Stereotactic radiotherapy (SRS) has become a widely used treatment for patients with brain metastases (BM). However, differential radionecorsis (RN) and tumor recurrence (TR) after SRS for BM by MR images is still challenging. In this study, a quantitative dynamic susceptibility contrasted perfusion weighted imaging (DSC-PWI) technique was applied to solve this problem. The results showed that quantitative DSC-PWI had higher diagnostic efficiency and smaller inter-observer differences than traditional DSC-PWI.}
}
@inproceedings{ISMRM2018_3787,
annote={ISMRM2018_3787},
pages={3787},
file={ISMRM2018_3787.pdf:ISMRM2018_3787.pdf:PDF},
title={Metabolic alterations in {DLPFC} in patients with Subclinical Hypothyroidism : An In-vivo 1H {MRS} study},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3787.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Subash Khushu and Mukesh Kumar Saini and Poonam Rana and Shilpi modi and Tarun Sekhri},
abstract={Altered cognitive performance is well known in both hypothyroidism and hyperthyroidism but little is known about deficits in brain functions in Subclinical hypothyroidism (SCH). Aim of the present study was to investigate the metabolic changes in Dorso-Lateral Pre-Frontal Cortex (DLPFC) of SCH patients using
1H MRS. 19 freshly diagnosed SCH patients and 24 age matched healthy controls were recruited and subjected to MRS. Our result show significantly increased concentrations of GSH (p<0.009) and creatine (p<0.017) in the DLPFC and diminished cognitive performance in SCH compared to controls. The increase in the level of GSH in SCH compared to controls may be indicative of an initial compensatory, neuro-protective response due to oxidative stress.}
}
@inproceedings{ISMRM2018_3788,
annote={ISMRM2018_3788},
pages={3788},
file={ISMRM2018_3788.pdf:ISMRM2018_3788.pdf:PDF},
title={Aberrant Brain Iron Deposition in Gray Matter Nuclei and Hippocampus in Alzheimer Disease with Type 2 Diabetes Mellitus: A Quantitative Susceptibility Mapping Study},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3788.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Xiaoxin Li and Yanwei Miao and Liang Han and Junyi Dong and Qingwei Song},
abstract={In this study, brain iron contents in basal nuclei, thalamus and hippocampus of AD+T2DM patients and AD-T2DM patients was quantified with susceptibility values by QSM and further to explore the correlation between brain iron deposition and cognition level and clinical factors. From the study results, we conclude that the susceptibility values were generally decreased due to aberrant iron deposition in gray matter nuclei in AD+T2DM patients relative to AD-T2DM patients. The susceptibility values of right GP has a better correlation with cognition, which administers to monitor the development of cognitive impairment.}
}
@inproceedings{ISMRM2018_3789,
annote={ISMRM2018_3789},
pages={3789},
file={ISMRM2018_3789.pdf:ISMRM2018_3789.pdf:PDF},
title={Motion of the cerebellum in patients with Chiari malformation compared to healthy subjects: A quantitative study using spiral cine {DENSE} {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3789.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={John Oshinski and Soroush Heidari Pahlavian and Jordan Schuster and Xiaodong Zhong and Rouzbeh Amini and Francis Loth and Daniel Barrow},
abstract={The goal of this study was to acquire mid-sagittal cine DENSE images to quantify displacement and strain over the cardiac cycle in patients with Chiari malformation and age-matched controls. The major finding of this study was that both tissue displacement and tissue strain in the parenchyma of the cerebellum was significantly greater in patients with Chiari malformation than healthy controls.}
}
@inproceedings{ISMRM2018_3790,
annote={ISMRM2018_3790},
pages={3790},
file={ISMRM2018_3790.pdf:ISMRM2018_3790.pdf:PDF},
title={Multi-modal {MRI} investigation of brain plasticity during prolonged Braille learning in sighted subjects – voxel-based morphometry and quantitative T1 mapping approach},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3790.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Bartosz Kossowski and Jacek Matuszewski and Łukasz Bola and Anna Banaszkiewicz and Małgorzata Paplińska and Michał Szczepanik and Marcin Szwed and Katarzyna Jednoróg and Artur Marchewka},
abstract={In order to study structural brain reorganization, multi-modal MRI combining voxel-based morphometry and quantitative T1 mapping was used in longitudinal design on sighted subjects who underwent tactile Braille reading course. Results show that methods are complimentary to each other. Combined approach like that gives insight into different aspects of tissue property changes introducing new opportunities for studying brain plasticity.}
}
@inproceedings{ISMRM2018_3791,
annote={ISMRM2018_3791},
pages={3791},
file={ISMRM2018_3791.pdf:ISMRM2018_3791.pdf:PDF},
title={Atlas-based volumetric assessment of T2 abnormality in acute spinal cord injury predicts motor outcomes: A transforming research and clinical knowledge in spinal cord injury ({TRACK}-{SCI}) pilot study},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3791.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={David B McCoy and Russell Huie and Sara M Dupont and William Whetstone and Sanjay Dhall and Rachel Tsolinas and Xuan Duong-Fernandez and Leigh Thomas and Vineeta Singh and Lisa Pascual and Jared Narvid and Nikolaos Kyritsis and Geoff Manley and Adam R Ferguson and Michael S Beattie and Jacqueline C Bresnahan and Jason F Talbott},
abstract={MR evaluation of intrinsic cord signal abnormality relies on gross morphologic imaging measures such as T2-hyperintense lesion length and subjective patterns of T2 signal abnormality. In the current study, we register T2w images and manually segmented lesions from acute SCI patients to a spinal cord (SC) anatomical template in order to calculate volumes of damaged tissue in 22 probabilistic anatomical subdomains of the SC. We identify specific anatomic subdomains in the SC which serve as MR biomarkers of motor impairment and indirectly support neuro-protective strategies targeting ventral horn and lateral column white matter tissue for maximizing motor function after SCI.
}
}
@inproceedings{ISMRM2018_3792,
annote={ISMRM2018_3792},
pages={3792},
file={ISMRM2018_3792.pdf:ISMRM2018_3792.pdf:PDF},
title={{CT} synthesis for {MR}-only brain radiotherapy treatment planning using convolutional neural networks},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3792.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Anna M. Dinkla and Jelmer M. Wolterink and Matteo Maspero and Mark H.F. Savenije and Joost J.C. Verhoeff and Ivana Isgum and Peter R. Seevinck and Jan J.W. Lagendijk and Cornelis A.T. van den Berg},
abstract={In MR-only radiotherapy, a synthetic CT (sCT) needs to be generated from MR to allow radiation dose planning without CT acquisition. We aim for such an MR-only workflow to decrease radiotherapy preparation time. If we can plan and deliver the dose in a single day, in a ‘one stop shop’ procedure, we prevent treatment delay which is of high importance for patients with fast growing brain metastases. In this study sCTs of the head were generated in a short amount of time, that highly resemble the original CTs and that enable accurate dose calculation.}
}
@inproceedings{ISMRM2018_3793,
annote={ISMRM2018_3793},
pages={3793},
file={ISMRM2018_3793.pdf:ISMRM2018_3793.pdf:PDF},
title={Fast synthetic {CT} generation using a conditional Generative Adversarial Network and Dixon imaging for general pelvis {MR}-based Radiotherapy planning},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3793.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Mark HF Savenije and Matteo Maspero and Anna M Dinkla and Peter R Seevinck and Cornelis AT van den Berg},
abstract={
To enable MR-only radiotherapy planning and accurate MR-based dose calculations, substitutes of CT images, so-called synthetic CT (sCT) images, need to be generated. In this work, we assessed whether sCT images generated by a 2D conditional Generative Adversarial Network (cGAN)using a 3D dual echo SPGR MRsequence were suited for radiation treatment planning for general pelvis cancer patients. Image evaluation showed comparable performance among prostate, rectum and cervix patients. Dose planning calculations demonstrated that accurate MR-based dose calculation on sCT images generated by the cGAN after training is feasible for treatment planning in prostate cancer patients. In addition, the generation of the sCT is fast (< 6 s) and ideally suited for applications where time duration is essential, e.g. MR-guided radiotherapy planning.}
}
@inproceedings{ISMRM2018_3794,
annote={ISMRM2018_3794},
pages={3794},
file={ISMRM2018_3794.pdf:ISMRM2018_3794.pdf:PDF},
title={{MR}-only Radiation Therapy Planning in the pelvis using Zero {TE} and {LAVA}-Flex based pseudo {CT} conversion.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3794.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Cristina Cozzini and Mikael Bylund and Joakim H Jonsson and Josef A Lundman and Fredrik Illerstam and Mathias Engstrom and Tufve Nyholm and Florian Wiesinger},
abstract={In this study, we demonstrate Zero TE (ZTE) and LAVA-Flex based pseudo CT conversion suitable for dose calculation for MR-only Radiation Therapy Planning (RTP) in the Pelvis. The dose planning performance of this method was evaluated in N=11 patients and compared to corresponding CT dose plans.}
}
@inproceedings{ISMRM2018_3795,
annote={ISMRM2018_3795},
pages={3795},
file={ISMRM2018_3795.pdf:ISMRM2018_3795.pdf:PDF},
title={Automated analysis of eye tumor {MR}-images for an improved treatment determination},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3795.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Mohamed Kilany Hassan and Denis Shamonin and Rahil Shahzad and Andrew Webb and Berend Stoel and Jan-Willem Beenakker},
abstract={The optimal treatment for uveal melanoma, the most common primary malignant eye tumor, depends on tumor thickness. Conventionally tumor thickness is determined with 2D ultrasound, but MRI allows for a full 3D analysis. It is, however, often difficult to determine the maximum tumor thickness due to its complex 3D shape. We propose a fully automatic framework to segment these MR-images to measure the tumor thickness accurately and evaluate it in four patients. The proposed method has a direct impact on the clinical practice, as a more accurate 3D assessment of the tumor dimensions directly influences therapy determination.}
}
@inproceedings{ISMRM2018_3796,
annote={ISMRM2018_3796},
pages={3796},
file={ISMRM2018_3796.pdf:ISMRM2018_3796.pdf:PDF},
title={{CT}-based surrogates of ventilation: A comparison with hyperpolarized Helium-3 and Xenon-129 {MRI} in lung cancer patients undergoing radiotherapy planning},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3796.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Bilal A. Tahir and Paul J. Hughes and Stephen D. Robinson and Helen Marshall and Alberto Biancardi and Neil J. Stewart and Graham Norquay and Ho-Fung Chan and Guilhem J. Collier and Kerry A. Hart and James A. Swinscoe and Matthew Q. Hatton and Jim M. Wild and Rob H. Ireland},
abstract={Image registration of lung CT images acquired at different inflation levels has been proposed as a surrogate method to map lung ‘ventilation’ and has notable applications in functionally guided radiotherapy planning. However, the technique requires validation against established ventilation modalities such as hyperpolarized gas MRI. Here, we develop an image acquisition and analysis strategy to facilitate direct spatial correlation of several CT ventilation techniques with both hyperpolarized 3He and 129Xe MRI and apply our method to a cohort of 11 lung cancer patients undergoing radiotherapy.}
}
@inproceedings{ISMRM2018_3797,
annote={ISMRM2018_3797},
pages={3797},
file={ISMRM2018_3797.pdf:ISMRM2018_3797.pdf:PDF},
title={Evaluation of {MRI}-Guided Radiotherapy Planning Target Volume Delineation for Colorectal Cancer Due to Variations in Image Contrast and Patient Motion},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3797.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yang Zhang and Liming Shi and Xiaonan Sun and Tianye Niu and Ning Yue and Jeon-Hor Chen and Tiffany Kwong and Min-Ying Su and Ke Nie},
abstract={This study evaluates the difference in defining the target volume of rectal cancer with MRI-guided radiation treatment planning. Tumors show different appearances on different MR sequences and also the motion of patients during the scan may affect defining planning target volume. A quantitative radial distance method was developed to evaluate variations coming from image contrast and patient motion. A total of 45 patients with pre- and post-radiation treatment MRI were analyzed. The mean difference in the radial distance between ROI’s drawn on different post-contrast images was 2-3 mm and the difference in the 90th percentile tumor pixel was 6-8 mm.}
}
@inproceedings{ISMRM2018_3798,
annote={ISMRM2018_3798},
pages={3798},
file={ISMRM2018_3798.pdf:ISMRM2018_3798.pdf:PDF},
title={An Automated Multiparametric {MRI} Quantitative Imaging Prostate Habitat Risk Scoring System for Defining External Beam Radiotherapy Boost Volumes},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3798.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Radka Stoyanova and Matthew C. Abramowitz and Felix Chinea and Deukwoo Kwon and Isildinha M Reis and Kyle R Padgett and Sanoj Punnen and Oleksandr N Kryvenko and Alan Pollack},
abstract={The standard of clinical care, Prostate Imaging, Reporting and Diagnosis System (PI-RADS), does not tap into the wealth of quantitative imaging information contained in the multiple sequences of mpMRI, nor does it elucidate intralesional spatial heterogeneity. A habitat risk score (HRS) approach that combines the quantitative information from the diffusion and perfusion mpMRI sequences is developed. HRS was devised in ten subcategories with increasing levels associated with a greater risk of harboring higher Gleason Score's and depicted as a heat map. The automated method is used to define radiotherapy (RT) boost volumes in the background of a randomized Phase II clinical trial.}
}
@inproceedings{ISMRM2018_3799,
annote={ISMRM2018_3799},
pages={3799},
file={ISMRM2018_3799.pdf:ISMRM2018_3799.pdf:PDF},
title={Longitudinal response monitoring in experimental prostate tumors by {DCE}-{MRI} after C-12 ion and photon radiotherapy},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3799.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Alina Leandra Bendinger and Christian Peter Karger and Charlotte Debus and Ralf Omar Floca and Jürgen Debus and Jörg Peter and Christin Glowa},
abstract={Dynamic contrast-enhanced MRI was used for the longitudinal monitoring of two well characterized experimental prostate tumors (Dunning R3327-AT1 and -HI) after isodose and isoeffective radiotherapy. The effect of carbon (12C)-ion irradition compared to photons on tumor vasculature was characterized by non-compartmental analysis and pharmacokinetic modelling employing the extended Tofts model. Isodose and isoeffective irradiation experiments indicated that the beam modality has a stronger effect on tumor perfusion and permeability than the dose. While changes in perfusion were identified for the highly undifferentiated AT1-tumor, the more differentiated HI-tumor showed only minor changes in perfusion upon irradiation.}
}
@inproceedings{ISMRM2018_3800,
annote={ISMRM2018_3800},
pages={3800},
file={ISMRM2018_3800.pdf:ISMRM2018_3800.pdf:PDF},
title={Lonidamine-induced selective acidification and deenergization of prostate cancer xenografts: Enhanced tumor response to radiation therapy},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3800.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Kavindra Nath and Jeffrey Roman and David Nelson and Mary Putt and Stepan Orlovskiy and Ewere Azagidi and Violet Tu and Dennis Leeper and Jerry Glickson},
abstract={Prostate cancer, when treated with external beam radiotherapy (RT) in the range of 78 Gy, is frequently associated with gastrointestinal (GI) \& genitourinary (GU) toxicities. We hypothesize that tumor sensitization by lonidamine (LND) will enable the use of lower RT doses reducing the risk of side effects. LND effects detected in vivo by 31P and 1H MRS in androgen-independent (PC3) prostate cancer xenografts produced a sustained and tumor-selective decrease in intracellular pH, bioenergetics (βNTP/Pi), oxygen consumption rate and increase in lactate. Selective tumor acidification, deenergization and oxygenation induced by LND potentiated the radiation response in the PC3 prostate cancer model.}
}
@inproceedings{ISMRM2018_3801,
annote={ISMRM2018_3801},
pages={3801},
file={ISMRM2018_3801.pdf:ISMRM2018_3801.pdf:PDF},
title={Comparative Assessment of Geometric Distortion for an {MR}-Linac Versus Several Diagnostic Scanners},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3801.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jordan Michael Slagowski and Yao Ding and Clifton David Fuller and Caroline Chung and Mo Kadbi and Zhifei Wen and Jihong Wang},
abstract={The integration of a MR scanner with a linear accelerator (MR-Linac) may improve image guidance in radiation therapy (RT). Spatial fidelity is an important consideration in RT and should be evaluated for MR-Linac imaging. This work presents a phantom and software developed in-house to measure geometric distortion across a large MR imaging field-of-view. A comparative assessment of geometric distortion within a 1.5T MR scanner integrated with a 7 MV linear accelerator is performed versus several commercial scanners with field strengths ranging from 1.5T-3.0T. The geometric distortion within the MR-Linac was comparable or less than that measured with the diagnostic scanners.}
}
@inproceedings{ISMRM2018_3802,
annote={ISMRM2018_3802},
pages={3802},
file={ISMRM2018_3802.pdf:ISMRM2018_3802.pdf:PDF},
title={Reduction of susceptibility artifacts in {MR} of permanent prostate gold seed for radiotherapy},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3802.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Abby Y Ding and Leon Ho and K.T Chan and Jing Yuan and Kin Yin Cheung and Siu Ki Yu},
abstract={Stereotactic body radiation therapy for prostate cancer is a highly precise radiotherapy. Post-implant MR is important for target localization, contouring and treatment planning. A phantom was designed to investigate the susceptibility caused by gold seeds in different orientations relative to B0 field. 2D and 3D acquisition scheme at various resolution, bandwidth and frequency-encoding directions were examined. Our results show that for reduction of susceptibility artifacts and excessive local signal loss, resolution of higher than 0.5mm is recommended, increasing bandwidth with sufficient resolution is more practical than changing frequency-encoding directions. 3D is comparable to 2D sequence in susceptibility artifacts.}
}
@inproceedings{ISMRM2018_3803,
annote={ISMRM2018_3803},
pages={3803},
file={ISMRM2018_3803.pdf:ISMRM2018_3803.pdf:PDF},
title={Longitudinal diffusion {MRI} for predicting response to radiotherapy in sarcoma patients},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3803.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yu Gao and Chunming Gu and Joong-hoon Kim and Minsong Cao and Anusha Kalbasi and Dan Ruan and Daniel A Low and Peng Hu and Yingli Yang},
abstract={In this work, we sought to predict the necrosis score, a surrogate of radiotherapy treatment outcome for sarcoma patients, using the longitudinal diffusion MRI data. Over three hundred features were extracted from the longitudinal diffusion data on twenty sarcoma patients. Minimum redundancy maximum relevance method with cross-validation was used to select the most relevant and stable features. Logistic regression, support vector machine and adaptive boosting were implemented to predict the necrosis score. AUC of 0.76 was achieved when using SVM with features from all three imaging time points. Features from before the treatment time point had better predictive power than data in the middle or after the treatment.}
}
@inproceedings{ISMRM2018_3804,
annote={ISMRM2018_3804},
pages={3804},
file={ISMRM2018_3804.pdf:ISMRM2018_3804.pdf:PDF},
title={Assessment Geometric Distortion in {MRI} for Gynaecological Brachytherapy Planning at 3T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3804.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Maria A Schmidt and Eva Kousi and Georgina Hopkinson and Anne Gasnier and Kate Roberts and Alexandra Taylor and Susan Lalondrelle},
abstract={MRI is increasingly used in radiotherapy treatment planning due to its superior soft tissue contrast. The growing interest in 3T MRI relates to the potential of higher signal-to-noise ratio and spatial resolution. However, geometric distortions associated with magnetic field inhomogeneity increase with field strength and may compromise geometric accuracy. We quantify the geometric distortion in MRI examinations for high dose rate brachytherapy planning for gynaecological cancer at 3T and consider its clinical impact, taking into account the brachytherapy applicators, the subject’s susceptibility distribution and hardware-related distortions. We found localised areas of field inhomogeneity and displacements of less than 1mm.}
}
@inproceedings{ISMRM2018_3805,
annote={ISMRM2018_3805},
pages={3805},
file={ISMRM2018_3805.pdf:ISMRM2018_3805.pdf:PDF},
title={Practical Aspects of {MRI}-based Gel Dosimetry in {RT} Quality Assurance},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3805.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Evanthia Kousi and Filipa Costa and Rollo Moore and Evangelos Pappas and Anne Gasnier and Emma Wells and Maria A Schmidt},
abstract={MRI-based gel dosimetry has been proposed as a part of a Radiotherapy QA programme and is of interest to Stereotactic Ablative Radiotherapy and Stereotactic Radiosurgery. MRI-related sources of error that may compromise the dosimetric accuracy need to be considered. R2 measurement variations associated with measurement timing after irradiation and SAR limitations were investigated using an anthropomorphic head phantom. Our results demonstrate gradual gel deformation and R2 variations that could have an impact on relative and absolute dose measurements.}
}
@inproceedings{ISMRM2018_3806,
annote={ISMRM2018_3806},
pages={3806},
file={ISMRM2018_3806.pdf:ISMRM2018_3806.pdf:PDF},
title={Use of a Rigidity Penalty to Improve {MR}-{CT} Image Registration},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3806.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Elizabeth MaryAnn McKenzie and Dan Ruan and Percy Lee and Ke Sheng},
abstract={Attenuation coefficients of tissue must be known to accurately model dose in radiation therapy. MR-guided radiation therapy better visualizes soft tissue, but it does not inherently contain attenuation information in the same way as CT images. CT and MR images can be registered to pool information, but the bones can become severely distorted. This work applies a rigidity penalty to bones segmented in CT, such that the soft tissue is allowed to deform while the bones remain rigid during CT to MRI registration. We show that this technique improves the registration, making the deformations more anatomically feasible.}
}
@inproceedings{ISMRM2018_3807,
annote={ISMRM2018_3807},
pages={3807},
file={ISMRM2018_3807.pdf:ISMRM2018_3807.pdf:PDF},
title={4D-{MRI} in radiotherapy: motion phantom study and automatic sorting based on internal surrogate for motion management during free breathing},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3807.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Soleakhena Ken and Oliver Bieri and Zarko Celicanin and Philippe Cattin and Laure Parent},
abstract={4D-MRI sequence for radiotherapy (RT) application is validated in this study on a motion phantom and on healthy volunteers. 4D-MR imaging of a moving spherical target with different signal waveforms gave similar results as for classical 4D-CT used in RT planning. During free breathing 4D-MRI acquisitions, the internal surrogates, defined as the mean intensity inside a region of interest are relevant to detect the different respiratory phases for consistent retrospective automatic image sorting. Feasibility of integration into treatment planning system was also demonstrated, allowing picturing the dynamic behavior of the moving organ for treatment planning.}
}
@inproceedings{ISMRM2018_3808,
annote={ISMRM2018_3808},
pages={3808},
file={ISMRM2018_3808.pdf:ISMRM2018_3808.pdf:PDF},
title={Comparative evaluation of {DTI} and {FLAIR} images in assessment of whole pathological region in {GBM} patients for {RT} planning; a semi-automatic segmentation approach},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3808.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Manijeh Beigi and Mojtaba Safari and Ahmad Ameri and Mohsen ShojaeeMoghadam and Hamidreza SalighehRad},
abstract={Accurate determination of whole pathological region is still a challenging task and necessary prerequisite step in radiotherapy planning in GBM. This study attempted to propose semi-automatic segmentation method that can extract whole pathogenic tumor on T2-FLAIR and isotropic component (p-map) of diffusion tensor imaging(DTI) with over 90 \% sensitivity, specificityand dice score. In addition, the extension of pathologicalregion was compared. Results show that there is significantdifference between segmentedregion on T2-FLAIR and p map. Beyond usual segmentation method for T2-FLAIR, we have highlighted DTI parametric maps because of its information on tumor infiltration.}
}
@inproceedings{ISMRM2018_3809,
annote={ISMRM2018_3809},
pages={3809},
file={ISMRM2018_3809.pdf:ISMRM2018_3809.pdf:PDF},
title={A Magnetic Resonance Imaging ({MRI}) and Computed Tomography ({CT}) compatible anthropomorphic pelvic phantom for {MRI}-guided radiotherapy.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3809.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Kamal Singhrao and Yingli Yang and Thomas Wong and Geraldine Chee and Jie Fu and Daniel Low and John H Lewis},
abstract={We present an anthropomorphic pelvic phantom for MR-guided radiotherapy. Materials were selected to mimic bone, fat and muscle and produce tissue-like contrast with T1, T2 and T2* weighted MRI sequences and CT. MR and CT tissue quantification results are presented. A comparison between the phantom and patient images acquired using standard prostate radiotherapy MR sequences is presented. The study concludes with an example application of the phantom where we compare the visibility of an implanted gold fiducial marker in phantom and in vivo.}
}
@inproceedings{ISMRM2018_3810,
annote={ISMRM2018_3810},
pages={3810},
file={ISMRM2018_3810.pdf:ISMRM2018_3810.pdf:PDF},
title={Repeatability of Quantitative Imaging on the {MR}-Linac for Treatment Response Monitoring},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3810.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ernst S. Kooreman and Petra J. van Houdt and Marlies E. Nowee and Vivian van Pelt and Folkert Koetsveld and Leon C. ter Beek and Johannes M. Peeters and Uulke A. van der Heide},
abstract={The MR-Linac opens the possibility for accurate daily treatment response monitoring. Quantitative MR imaging is a promising tool to quantify day-to-day changes. Therefore the performance of quantitative imaging of the MR-Linac needs to be assessed. In this study, we investigated the repeatability of T2 and ADC mapping using test-retest data of patients with prostate cancer. We calculated the within-patient coefficient of variation (wCV) and compare this to data from a conventional diagnostic 3T scanner. The MR-Linac performs similar to the diagnostic scanner regarding T2 mapping as wCV values are comparable. However, the repeatability for ADC mapping is lower on the MR-Linac.}
}
@inproceedings{ISMRM2018_3811,
annote={ISMRM2018_3811},
pages={3811},
file={ISMRM2018_3811.pdf:ISMRM2018_3811.pdf:PDF},
title={Susceptibility-based positive contrast for visualization and localization of implanted brachytherapy seeds in realistic prostate phantoms},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3811.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Reyhaneh Nosrati and Matt Wronski and Ananth Ravi and Ana Pejović-Milić and Gerard Morton and Greg Stanisz},
abstract={Employing susceptibility-based positive contrast for depiction and localization of closely implanted elongated paramagnetic objects (i.e. brachytherapy seeds) is very challenging due to the orientation dependence and/or size overestimation of reconstructed object. In this study, 321 brachytherapy seeds were implanted in four realistic prostate phantoms; all phantoms were scanned at three different angles on a 1.5T MR scanner. A novel susceptibility-based workflow was proposed for visualization and localization of the seeds. For all scanning angles the reconstructed seed shapes, centroids and orientations were identical and no significant difference was found between the proposed method and the current clinically used CT-based method.}
}
@inproceedings{ISMRM2018_3812,
annote={ISMRM2018_3812},
pages={3812},
file={ISMRM2018_3812.pdf:ISMRM2018_3812.pdf:PDF},
title={Response Assessment in Carbon-Ion Radiotherapy of Recurrent High Grade Glioma through Characterization of Tumor Vascularization and Perfusion using {DCE} {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3812.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Charlotte Debus and Maximilian Knoll and Ralf Floca and Sebastian Adeberg and Jürgen Debus and Amir Abdollahi},
abstract={Carbon-ion radiotherapy holds great potential for treatment of recurrent high-grade glioma, where re-irradiation is difficult due to prior dose burden. We investigated effects of carbon RT on tumor micro-vascularization and micro-circulation, by evaluating semi-quantitative parameters derived from DCE MRI before and after irradiation. Results show augmented perfusion parameters AUC, maximum enhancement and wash-out after therapy compared to pre-RT scans and lower AUC, wash-in, wash-out and final uptake for responders to therapy compared to non-responders. Additionally, significantly lower values for AUC, wash-out, maximum enhancement and final uptake could be observed for progressed tumor volumes compared to irradiated tumor volumes.}
}
@inproceedings{ISMRM2018_3813,
annote={ISMRM2018_3813},
pages={3813},
file={ISMRM2018_3813.pdf:ISMRM2018_3813.pdf:PDF},
title={Changes in Apparent Diffusion Coefficient ({ADC}) of the Dominant Tumor during Dose-Painted Radiotherapy and High Dose Rate ({HDR}) Brachytherapy for Prostate Cancer},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3813.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Sangjune Lee and Jenny Lee and Tim Craig and Alejandro Berlin and Peter Chung and Cynthia Ménard and Warren Foltz},
abstract={PIRADS-2 compliant Apparent Diffusion Coefficient mapping (ADC) and T2-weighted imaging was performed at baseline and week 6 of radiotherapy in 57 patients with localized prostate cancer. 101 radiomics features were calculated across the gross tumor volume (GTV) and whole prostate (WP). GTV ADC histogram metrics (10 percentile, median, mean) increased (p<1e-06) at equivalent maximum ADC values. High percentile WP ADC histogram metrics (90 percentile, maximum) decreased (p<2e-05) at equivalent 10 percentile/median/mean values. Between 44 (for GTV ADC) and 65 (for WP applied to T2w-weighted images) radiomics features were significantly different and will be explored as potential early predictive biomarkers of response.}
}
@inproceedings{ISMRM2018_3814,
annote={ISMRM2018_3814},
pages={3814},
file={ISMRM2018_3814.pdf:ISMRM2018_3814.pdf:PDF},
title={Quantification of {MRI} visibility and artefacts at 3T of liquid fiducial marker in a pancreas tissue mimicking phantom},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3814.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Sergej Schneider and Rasmus Irming Jølck and Esther Gera Cornelia Troost and Aswin Louis Hoffmann},
abstract={In image-guided radiotherapy (IGRT) of patients with pancreatic ductal adenocarcinoma (PDAC), implanted fiducial gold markers are used for position verification and for registration of computed tomography (CT) and MRI scans used for delineation purposes. Recently, a liquid biodegradable carbohydrate based injectable soft tissue marker, compatible with CT and MRI, has been developed. Our aim was to quantitatively evaluate the tradeoff between visibility and artifacts of this marker on MRI and compare this with two solid fiducial gold markers commonly used in IGRT of PDAC.}
}
@inproceedings{ISMRM2018_3815,
annote={ISMRM2018_3815},
pages={3815},
file={ISMRM2018_3815.pdf:ISMRM2018_3815.pdf:PDF},
title={Respiratory-Resolved Single-Shot Fast Spin Echo with Improved Volume Consistency},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3815.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Anne Menini and Daniel V Litwiller and Yuji Iwadate and Ersin Bayram},
abstract={We present a motion-correction-based method for improving through-slice volume consistency for respiratory-resolved single-shot fast spin echo for the purposes of image-guided radiation therapy planning.
}
}
@inproceedings{ISMRM2018_3816,
annote={ISMRM2018_3816},
pages={3816},
file={ISMRM2018_3816.pdf:ISMRM2018_3816.pdf:PDF},
title={Anisotropy of Anomalous Diffusion Helps in Grading of Gliomas},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3816.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Boyan Xu and Lu Su and Zhenxiong Wang and Yang Fan and Bing Wu and Gaolang Gong and Wenzhen Zhu and Peiyi Gao and Jia-Hong Gao},
abstract={Anomalous diffusion model has been introduced and shown to be beneficial in clinical applications, compared with conventional diffusion models. However, the anisotropy of anomalous diffusion was neglected and its clinical feasibility remains uncertain. In this study, the use of anisotropy of anomalous diffusion is investigated for differentiating low- and high-grade cerebral gliomas. Based on the results, it is shown that the anisotropy of anomalous diffusion offers advantages compared to that of conventional diffusion models, indicating its potential to facilitate future studies of neuropathological changes in clinical populations.}
}
@inproceedings{ISMRM2018_3817,
annote={ISMRM2018_3817},
pages={3817},
file={ISMRM2018_3817.pdf:ISMRM2018_3817.pdf:PDF},
title={The Restricted Diffusion Model for Differentiation of Tumor from Normal Tissue in Glioblastoma},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3817.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yuan Li and Michelle Kim and Theodore Lawrence and Parmar Hemant and Yue Cao},
abstract={It is a challenge to differentiate non-enhanced solid tumor from edema in glioblastoma. This study applied the restricted diffusion model to high b-value diffusion weighted images to characterize glioblastoma. The formation of the restricted diffusion model was derived for bi-polar diffusion gradients. The parameters fitted by the restricted diffusion model can differentiate solid tumor from edema and normal-appearing white matter and grey matter, better than the conventional apparent diffusion coefficient and the bi-exponential model without accounting for diffusion restriction of intra-cellular water.}
}
@inproceedings{ISMRM2018_3818,
annote={ISMRM2018_3818},
pages={3818},
file={ISMRM2018_3818.pdf:ISMRM2018_3818.pdf:PDF},
title={Intravoxel incoherent motion ({IVIM}) provides reliable measures of blood volume in patients with metastases to the brain},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3818.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Line Brennhaug Nilsen and Knut Håkon Hole and Ingrid Digernes and Endre Grøvik and Oliver Geier and Edmund Reitan and Cathrine Saxhaug and Åslaug Helland and Kari Dolven Jacobsen and Birger Breivik and Dag Ottar Sætre and Kyrre Eeg Emblem},
abstract={In this study, we aimed to assess the potential of using intravoxel incoherent motion (IVIM) for measuring cerebral blood volume (CBV) in brain metastases and normal brain tissue. DWI was acquired with b=0, 200, 300 and 1000s/mm
2 in nineteen patients with 23 brain metastases from lung cancer. Asymptotic IVIM fitting yielded an estimation of the perfusion fraction and subsequent estimation of CBV. CBV
DWI in brain metastases and gray matter correlated significantly with CBV obtained from conventional DSC MRI. Our results suggest that IVIM may serve as an independent and reliable surrogate marker of blood volume in well perfused brain tissue.}
}
@inproceedings{ISMRM2018_3819,
annote={ISMRM2018_3819},
pages={3819},
file={ISMRM2018_3819.pdf:ISMRM2018_3819.pdf:PDF},
title={In Vivo Assessment of Lauren Classification for Gastric Cancer Using Diffusion {MRI} with a Fractional Order Calculus Model},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3819.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Muge Karaman and Lei Tang and Ziyu Li and Yu Sun and Jia Fu Ji and Xiaohong Joe Zhou},
abstract={Gastric cancer (GC) is the second most common cause of cancer-related mortality globally. Histological assessment of GC has been based on Lauren classification which categorizes the tumor according to its morphological features. In respond to the need for probing biological tissue complexity, a growing number of diffusion-weighted imaging studies have focused on revealing tissue microstructures by measuring non-Gaussian diffusion behaviors. One of these techniques is the fractional order calculus (FROC) model. In this study, we have used the FROC model to investigate non-invasive imaging-based assessment of GC, providing an alternative to histopathology-based Lauren classification.}
}
@inproceedings{ISMRM2018_3820,
annote={ISMRM2018_3820},
pages={3820},
file={ISMRM2018_3820.pdf:ISMRM2018_3820.pdf:PDF},
title={Whole Body Magnetic Resonance Imaging in Paediatric Hodgkin’s Lymphoma; The Application of Quantitative Parameters for Nodal Staging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3820.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Arash Latifoltojar and Paul D Humphries and Athar Haroon and Leon Menezes and Shonit Punwani},
abstract={Nodal disease on whole-body MRI (WB-MRI) is mainly assessed using size criteria that could misclassify sub-centimeter lymphomatous nodes. In this study we investigated the comparative performance of anatomical WB-MRI derived nodal-size and signal-intensity; and whole-body diffusion-weighted-imaging (WB-DWI) nodal-size and apparent-diffusion-coefficient (ADC) measurements for determination of nodal-disease status. We showed that diseased nodes had significantly lower ADCs than benign nodes. We also noticed that for nodes deemed negative for disease based on size criteria (measuring 5-9 mm) ADC was significantly lower for FDG PET-CT -positive compared to FDG PET-CT -negative nodes. We also note that the performance of ADC was not greater than simple size measurement and concluded that there were no added advantage for quantitative measurements to simple size criteria on WB-MRI.}
}
@inproceedings{ISMRM2018_3821,
annote={ISMRM2018_3821},
pages={3821},
file={ISMRM2018_3821.pdf:ISMRM2018_3821.pdf:PDF},
title={Whole body 3.0 T {MRI} for Staging Lymphomas: An Assessment of Multiple Sequences Compared to Reference Standard Imaging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3821.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Arash Latifoltojar and Mark Duncan and Maria Klusmann and Alan Bainbridge and Deena Neriman and Francesco Fraioli and Jonathan Lambert and Kirit Ardeshna and Shonit Punwani},
abstract={In lymphomas, whole-body MRI (WB-MRI), integrating structural / functional MRI sequences, offers an alternative radiation-free imaging method to standard radiological techniques. In this work, we evaluated multiple MRI sequences as part of a WB-MRI protocol for staging of 22 newly-diagnosed Hodgkin’s lymphoma and diffuse large B-cell lymphoma patients compared to reference-standard 18F-FDG PET-CT. We found that the performance of WB-MRI for nodal / extra-nodal disease detection and Ann-Arbor staging were at best when the entire protocol was reviewed. We observed an inferior diagnostic performance of WB-MRI using diffusion-weighted-imaging and an improved diagnostic performance when T2-weighted / post-contrast WB-MRI were reviewed.}
}
@inproceedings{ISMRM2018_3822,
annote={ISMRM2018_3822},
pages={3822},
file={ISMRM2018_3822.pdf:ISMRM2018_3822.pdf:PDF},
title={The effect of flow suppression on {BOLD} {MRI} of lung tumor},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3822.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Heling Zhou and Olivier Belzile and Zhang Zhang and Jo Wagner and Chul Ahn and James Richardson and Debabrata Saha and Rolf A Brekken and Ralph P Mason},
abstract={Blood oxygen level dependent (BOLD) MRI is used to provide information on tumor oxygenation. However, the measurements are susceptible to blood flow changes, which often occur during hyperoxic gas challenge. This study investigated the extent of flow sensitivity by comparing BOLD measurements with and without flow suppression using two orthotopic lung xenograft tumor models. Flow suppression was found to affect multiple measurements including ΔSI(\%) and R
2*. The range of discrepancy was smaller in R
2* than the ΔSI(\%). High similarity was found in spatial patterns. ROI and spatial pattern analysis showed higher sensitivity to flow in A549 tumors than H460 tumors.}
}
@inproceedings{ISMRM2018_3823,
annote={ISMRM2018_3823},
pages={3823},
file={ISMRM2018_3823.pdf:ISMRM2018_3823.pdf:PDF},
title={High b value (2000 s/mm2) Diffusion-weighted Imaging in Prostate Cancer Detection: Comparison between Zoomed Field of View (i{ZOOM}) with a Two Dimensional Radiofrequency Pulse (2D-{RF}) Echo Planar Imaging ({EPI}) Sequence and Conventional ss-{EPI} {DWI} at 3.0 T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3823.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Shuai Ma and Kangjie Xu and Huihui Wang and Huihui Xie and Hongxia Sun and Juan Wei and Xiaodong Zhang and Xiaoying Wang},
abstract={This study aims to evaluate diagnostic efficacy of high b value (2000s/mm2) zoomed field of view (iZOOM) with a 2D-RF EPI sequence, compared with conventional ss-EPI (CONV) diffusion-weighted imaging (DWI) for peripheral zone (PZ) prostate cancer (PCa) detection at 3.0 T. Prostate Imaging Reporting and Data System version 2 (PI-RADS v2) were used as evaluation tool and the TRUS-guided systematic plus targeted biopsies was considered as reference standard. It demonstrated iZOOM could provide excellent visual conspicuity as well as a better diagnostic performance compared with CONV DWI in PZ, especially in the small lesions and the lesions abutting the capsule.}
}
@inproceedings{ISMRM2018_3824,
annote={ISMRM2018_3824},
pages={3824},
file={ISMRM2018_3824.pdf:ISMRM2018_3824.pdf:PDF},
title={Differentiation of Normal and Radioresistant {DU}145 Tumour Xenografts in Mice Using {CEST} {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3824.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Wilfred W Lam and Wendy Oakden and Leedan Murray and William Chu and Stanley K Liu and Greg J Stanisz},
abstract={The differentiation of normal and radioresistant tumour potentially allows the tailoring of cancer treatment to the patient. DU145 prostate cancer cells from normal and radioresistant cell lines were injected in mouse hind limb and allowed to grow into tumours. The tumours were imaged within 48 h before and after x-ray therapy using CEST. The magnetization transfer ratio (MTR) was compared between tumours grown from each cell line and at both time points. The MTR was significantly different at a frequency offset of –3.3 ppm at both time points. T
1 and T
2 values were not found to be significantly different.}
}
@inproceedings{ISMRM2018_3825,
annote={ISMRM2018_3825},
pages={3825},
file={ISMRM2018_3825.pdf:ISMRM2018_3825.pdf:PDF},
title={Diffusion weighted {MRI} simplifies therapy monitoring in {TRAMP} mice},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3825.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jana Kim and Caroline K Søgaard and Eugene Kim and Tone F Bathen and Marit Otterlei and Siver A Moestue and Deborah K Hill},
abstract={Transgenic mouse models of prostate cancer have advantages over xenograft tumor models as the cancer arises spontaneously and can be studied in immunocompetent mice, thus being highly biologically relevant. However, in vivo monitoring of cancer progression and treatment response is challenging and most studies rely on prostate volume measurements. Here we show that diffusion weighted imaging is a helpful tool for assessing response to chemotherapy in transgenic adenocarcinoma of the mouse prostate (TRAMP) mice.}
}
@inproceedings{ISMRM2018_3826,
annote={ISMRM2018_3826},
pages={3826},
file={ISMRM2018_3826.pdf:ISMRM2018_3826.pdf:PDF},
title={Standard Diffusion-Weighted, Diffusion Kurtosis and Intravoxel Incoherent Motion {MR} Imaging of Sinonasal Malignancies: Correlations with Ki-67 Proliferation Status},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3826.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Zebin Xiao and Zuohua Tang and Jinwei Qiang and Yufeng Zhong and Rong Wang and Zhongshuai Zhang},
abstract={This study aimed to explore the correlations between parameters derived from standard diffusion-weighted imaging (DWI), diffusion kurtosis imaging (DKI) and intravoxel incoherent motion (IVIM) with the Ki-67 proliferation status. Our preliminary study shows that DWI-derived parameters from different models are capable of providing different pathophysiological information. DWI, DKI and IVIM parameters are associated with Ki-67 proliferation status. Kmax derived from DKI is the strongest independent factor for the prediction of Ki-67 proliferation status.}
}
@inproceedings{ISMRM2018_3827,
annote={ISMRM2018_3827},
pages={3827},
file={ISMRM2018_3827.pdf:ISMRM2018_3827.pdf:PDF},
title={Intravoxel Incoherent Motion {MR} Imaging in the Differentiation between Benign and Malignant Sinonasal Lesions: Comparison with Conventional Diffusion-Weighted {MR} Imaging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3827.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Zebin Xiao and Zuohua Tang and Jinwei Qiang and Yufeng Zhong and Rong Wang and Zhongshuai Zhang},
abstract={This study aimed to evaluate the value of intravoxel incoherent motion (IVIM) in the differentiation between benign and malignant sinonasal lesions and to compare the diagnostic performance of IVIM with conventional diffusion-weighted imaging (DWI). Our preliminary study shows that ADC, D and f values may be considered as discriminating markers for identifying benign and malignant sinonasal lesions. The combination of D and f values demonstrates significantly higher sensitivity, specificity and accuracy than the ADC value, revealing that IVIM appears to be a more valuable tool than conventional DWI for distinguishing benign from malignant sinonasal lesions.}
}
@inproceedings{ISMRM2018_3828,
annote={ISMRM2018_3828},
pages={3828},
file={ISMRM2018_3828.pdf:ISMRM2018_3828.pdf:PDF},
title={{ADC} histogram analysis of rectal cancer patients for early detection of therapeutic efficacy of neoadjuvant radio-chemotherapy: initial results.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3828.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Martin Buechert and Oliver Schäfer},
abstract={Successful monitoring of neoadjuvant radiochemo therapy will allow early selection of responder and non-responder. Beside conventional morphological MRI additional functional MRI in combination with advanced analysis strategies like histogram analysis of ADC values are promising. Initial results of an ongoing clinical study are presented.}
}
@inproceedings{ISMRM2018_3829,
annote={ISMRM2018_3829},
pages={3829},
file={ISMRM2018_3829.pdf:ISMRM2018_3829.pdf:PDF},
title={Intravoxel incoherent motion ({IVIM}) imaging for differential diagnosing hepatocellular carcinoma ({HCC}), hepatic hemangioma({HHA}) and hepatic metastasis({HM}).},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3829.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ye Ju and Ailian Liu and Meiyu Sun and Lihua Chen and Lizhi Xie},
abstract={The diffusion property of tumor tissues largely depends on cell density, which may also be predictive features of malignancy in some types of tumors. Intravoxel incoherent motion (IVIM) imaging is an extension of diffusion weighted imaging (DWI) that can be used to investigate both diffusion and perfusion changes in tissues. Comparing the IVIM parameters between carcinoma (HCC), hepatic hemangioma and hepatic metastasis, we found that IVIM can facilitates understanding of tumor tissue characteristics of perfusion and diffusion and it may provide more useful information to distinguish hemangiomas from other two malignant tumors.}
}
@inproceedings{ISMRM2018_3830,
annote={ISMRM2018_3830},
pages={3830},
file={ISMRM2018_3830.pdf:ISMRM2018_3830.pdf:PDF},
title={Visualization of Peritumoral Fasciae by Dual-band Long-T2 Saturation {UTE} at 7T {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3830.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yupeng Cao and Xiaohan Zhou and Yang Fan and Yuqing Wang and Wentao Liu and Dong Han},
abstract={Fasciae are related with the tumor invasion. To investigate the alteration of peritumoral fasciae during tumor invasion, a novel dual-bandlong-T2saturation UTE sequence was proposed in this study. This sequence was applied to suppress the signal from long-T2 tissue components, consequently directly providing short-T2 contrast. Tumor-bearing Balb/c mouse was scanned on a 7T MRI scanner with the proposed sequence and standard FLASH to compare the quality of fasciae imaging. The results showed that the long-T2 signal was effectively suppressed and the peritumoral fasciae was visualized with this novel technique. This technique will give potential clinical feasibility of the fascia-related diseases.}
}
@inproceedings{ISMRM2018_3831,
annote={ISMRM2018_3831},
pages={3831},
file={ISMRM2018_3831.pdf:ISMRM2018_3831.pdf:PDF},
title={Detecting Glioblastoma invasion using Multi-parametric {MRI} and Quantitative Assessment with in-plane Histology},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3831.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Haitham Farooq Al-Mubarak and Antoine Vallatos and Jim Birch and Lindsay Gallagher and Joanna Birch and Lesley Glmour and John Foster and William Holmes and Anthony Chalmers},
abstract={We evaluate the ability of a range of MRI techniques to probe glioblastoma invasion in a mouse model by comparison with in-plane stacked histology, enabling a direct voxel-to-voxel comparison between MRI and histology (HLA stain). We used the G7 mouse model which exhibits highly invasive tumour margins and scanned using T1 weighted, T2 weighted, T2map, Diffusion Tensor Imagining (DTI) and Perfusion Weighting Imaging (PWI). Registration of MRI datasets with stacked in-plane histology allows direct quantitative validation using DICE and ROC analysis, showing that PWI gave the best indication of tumour cell invasion.}
}
@inproceedings{ISMRM2018_3832,
annote={ISMRM2018_3832},
pages={3832},
file={ISMRM2018_3832.pdf:ISMRM2018_3832.pdf:PDF},
title={Non-linear Mechanics Allows Non-invasive Quantification of Interstitial Fluid Pressure},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3832.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Daniel Fovargue and Jack Lee and Marco Fiorito and Adela Capilnasiu and Sweta Sethi and Stefan Hoelzl and Jurgen Henk Runge and Jose de Arcos and Arnie Purushotham and Khesthra Satchithananda and David Nordsletten and Ralph Sinkus},
abstract={Established tumour treatments include drugs and the emerging class of cell-based therapies. Individual tumours can counteract the delivery of the therapy, for example, they can feature high internal pressures (IFP) caused by blood vessels that are different from normal tissues. Furthermore, a drop in IFP is a well-established marker for successful therapy. Here we demonstrate in simulations, phantom experiments, fatty breast tissue and a benign breast lesion that tissue biomechanics as quantified via MR-Elastography (MRE) allows in combination with non-linear mechanics to estimate IFP in absolute units non-invasively.}
}
@inproceedings{ISMRM2018_3833,
annote={ISMRM2018_3833},
pages={3833},
file={ISMRM2018_3833.pdf:ISMRM2018_3833.pdf:PDF},
title={Pilot Study of Rapid {MR} Pancreas Screening for Patients with {BRCA} Mutation},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3833.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Giuseppe Corrias and Andrea Agostini and Gabriella Carollo and Luca Saba and Lorenzo Mannelli},
abstract={Patients with BRCA mutations are offered breast MRI because of their increased risk of breast cancer, but no screening strategy is available for other BRCA-associated malignancies including pancreatic ductal adenocarcinoma. In this protocol, we optimize the use of several recent developments in body MRI for a rapid pancreatic screening in BRCA mutation carriers: first, rapid relatively motion insensitive T2-weighted imaging (T2WI) and navigator triggering (NT), where real-time tracking of the diaphragm position is performed. Secondly advances in diffusion-weighted-imaging (DWI). These techniques have changed our ability to screen for malignancies, in specific organs, such as the pancreas.}
}
@inproceedings{ISMRM2018_3834,
annote={ISMRM2018_3834},
pages={3834},
file={ISMRM2018_3834.pdf:ISMRM2018_3834.pdf:PDF},
title={Monitoring the Growth of Individual Tumours in the Mouse Lung using Cardio-Respiratory Synchronised b{SSFP} {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3834.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ana L. Gomes and Paul Kinchesh and Danny Allen and Veerle Kersemans and Stuart Gilchrist and Luiza Madia-Lourenco and Anderson Ryan and Sean C. Smart},
abstract={bSSFP imaging is used in-vivo to image small tumours in the mouse lung, at an isotropic resolution of 200µm in under 10 minutes per scan. Cardio-respiratory synchronisation using prospective gating control is used to minimise motion artefacts efficiently and a 4 step RF phase cycle is used to eliminate banding artefact. Growth of individual tumours in multi-focal lung cancer can be measured with a throughput of >4 mice per hour.}
}
@inproceedings{ISMRM2018_3835,
annote={ISMRM2018_3835},
pages={3835},
file={ISMRM2018_3835.pdf:ISMRM2018_3835.pdf:PDF},
title={Towards an ultra-high field virtual biopsy for hepatic cancers using phospholipid metabolism},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3835.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Deb Rivera and IML van Kalleveen and Catalina Arteaga de Castro and Hanneke Laarhoven and Dennis Klomp and Wybe van der Kemp and Jaap Stoker and Aart Nederveen},
abstract={At 7T 31P spectroscopy becomes possible on clinically relevant scales. Here we tackle the greatest challenge in multi-parametric imaging at high-field – creating localizers and radiological-grade images in the body in the absence of a bore body coil. By using antennas rather than loop coils, we image the full extent of the liver (n=10). Combining antennas with parallel transmit, allows radiological-grade images. Although technically feasible, it is not yet possible to obtain multi-nuclear spectra and parallel transmit images within the same scan session. We combine the methods by rebooting the scanner mid-exam and demonstrate the method can be used for imaging patients.}
}
@inproceedings{ISMRM2018_3836,
annote={ISMRM2018_3836},
pages={3836},
file={ISMRM2018_3836.pdf:ISMRM2018_3836.pdf:PDF},
title={{CEST} {MRI} to contrast chondrosarcoma tumors: two contrasts in one acquisition.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3836.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Leslie Mazuel and Aurélien Voissière and Valérie Weber and Yvain Gérard and Sophie Besse and Jean-Marie Bonny and Elisabeth Miot-Noirault and Caroline Peyrode and Guilhem Pagès},
abstract={This study aims to develop a non-invasive CEST MRI method to evaluate simultaneously pH and glycoaminoglycans (GAG) as a new imaging method for assessing hypoxic and chondrogenic status in chondrosarcomain vivo.}
}
@inproceedings{ISMRM2018_3837,
annote={ISMRM2018_3837},
pages={3837},
file={ISMRM2018_3837.pdf:ISMRM2018_3837.pdf:PDF},
title={Multi-exponential T2* mapping distinguishes benign/malignant lymph nodes in rectal cancer patients: an ex-vivo and in-vivo experiment},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3837.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Inês Santiago and João Santinha and Andrada Ianus and Nickolas Papanikolaou and Celso Matos and Noam Shemesh},
abstract={In rectal cancer patient management, quality-of-life compromise due to unnecessary neoadjuvant chemoradiation is a major concern and may be driven by false positive lymph node(LN) staging. We sought to distinguish benign LNs from LNs with different patterns of malignant infiltration by investigating multi-exponential decay in multi-gradient-echo(MGE) MRI ex-vivo, at 16.4T. The experiment was translated to the clinic and performed at 1.5T during rectal cancer staging. We found that the 2-compartment model of T2* decay allows malignant and benign LNs to be distinguished in clinical images with a higher specificity than that of conventional criteria, namely short-axis>5mm, border irregularity and mixed signal intensity.}
}
@inproceedings{ISMRM2018_3838,
annote={ISMRM2018_3838},
pages={3838},
file={ISMRM2018_3838.pdf:ISMRM2018_3838.pdf:PDF},
title={Levels of choline-containing compounds are not increased in human liver metastases of colorectal cancer: an assessment by 1H {MR} spectroscopy},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3838.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Edwin E.G.W. ter Voert and Linda Heijmen and Jack J.A. van Asten and Alan J. Wright and Iris D. Nagtegaal and Cornelis J.A. Punt and Johannes H.W. de Wilt and Hanneke W.M. van Laarhoven and Arend Heerschap},
abstract={The commonly observed relative signal increase of choline-containing compounds (tCho) in
1H MR spectra of tumors may serve as a diagnostic biomarker. Here we evaluate the potential of this tCho signal in
1H MR spectra of the human liver to assess metastases of colorectal cancers. An increased tCho signal was not observed for these metastases. With increasing tumor volumes, the tissue levels of tCho decreased. The likely reason is a larger necrotic voxel fraction as it correlated with more higher ADC values assessed by diffusion weighted imaging. A Bland-Altman analysis revealed average repeatability in normal livers and poor repeatability in tumors.}
}
@inproceedings{ISMRM2018_3839,
annote={ISMRM2018_3839},
pages={3839},
file={ISMRM2018_3839.pdf:ISMRM2018_3839.pdf:PDF},
title={Relationship of apparent diffusion coefficient on diffusion-weighted imaging and tumour burden in ovarian cancer},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3839.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={He An and Elaine Lee and Queenie Chan},
abstract={To investigate the relationship of apparent diffusion coefficient (ADC) on diffusion-weighted imaging (DWI) and tumour burden in ovarian cancer. The ADC of primary ovarian tumour (ADCpri), peritoneal carcinomatosis (ADCmet) and the ratio of ADCmet/ADCpri (ADCratio) were correlated with the total tumour volume (TV) contoured on T2WI as representation of tumour burden in ovarian cancer. Significant correlations were found between ADCmet and TV and between ADCratio and TV. Our study suggested that the analysis of ADC might provide important information on tumour burden in OC.
}
}
@inproceedings{ISMRM2018_3840,
annote={ISMRM2018_3840},
pages={3840},
file={ISMRM2018_3840.pdf:ISMRM2018_3840.pdf:PDF},
title={Over-discretized {SENSE} reconstruction and B0 correction for accelerated non-lipid suppressed 1H {FID} {MRSI} of the human brain at 9.4T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3840.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Sahar Nassirpour and Paul Chang and Anke Henning},
abstract={In this study the acquisition of high resolution (64x64) metabolite maps at 9.4T using a non-lipid suppressed ultra-short TR and TE
1H FID MRSI sequence is accelerated using an improved over-discretized SENSE reconstruction and B
0 correction method. The improved reconstruction is compared to conventional SENSE and GRAPPA reconstruction and reproducible metabolite maps are acquired using this technique.}
}
@inproceedings{ISMRM2018_3841,
annote={ISMRM2018_3841},
pages={3841},
file={ISMRM2018_3841.pdf:ISMRM2018_3841.pdf:PDF},
title={{SNR} Requirements for Successful Application of Compressed Sensing Acceleration to Non-lipid suppressed 1H {MRSI} at Ultra-High Fields},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3841.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Sahar Nassirpour and Paul Chang and Nikolai Avdievitch and Anke Henning},
abstract={In this work we systematically investigate the requirements for successful application of compressed sensing for highly accelerating the acquisition of non-lipid suppressed
1H FID MRSI data at ultra-high fields. It is shown that with a combination of parallel imaging and sparse reconstruction and an RF coil with an even distribution of receive sensitivity, highly accelerated and high resolution metabolite maps can be acquired at 9.4T through compressed sensing.}
}
@inproceedings{ISMRM2018_3842,
annote={ISMRM2018_3842},
pages={3842},
file={ISMRM2018_3842.pdf:ISMRM2018_3842.pdf:PDF},
title={Arbitrary Variable Density ({AVD})-{GRAPPA} Enabled {EPSI} of Short-echo 3D H1-{MRSI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3842.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Maryam Vareth and Yan Li and Misung Han and Marram P. Olson and Jason Crane and Sarah J. Nelson and Janine M. Lupo},
abstract={This work investigates the feasibility of using arbitrary sampling patterns and GRAPPA-EPSI reconstruction to shorten the acquisition time and increase the spatial resolution of short-echo 3D-MRSI for routine clinical purposes. Fully sampled data were retrospectively under-sampled to achieve effective acceleration rates of 2, 3 and 4 using a variety of sampling patterns. The modified GRAPPA algorithm: 1) took advantage of the FID time points, 2) handled arbitrary sampling patterns and 3) used a fast, high-resolution external calibration acquisition to estimate sensitivity maps.}
}
@inproceedings{ISMRM2018_3843,
annote={ISMRM2018_3843},
pages={3843},
file={ISMRM2018_3843.pdf:ISMRM2018_3843.pdf:PDF},
title={Comparison of Compressed Sensing Reconstruction for 3D Echo Planar Spectroscopic Imaging data using Total Variation and Statistically Optimized Perona-Malik Non-linear Diffusion},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3843.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Andres Saucedo and Ajin Joy and Eric S. Daar and Mario Guerrero and Joseph Suresh Paul and Manoj K. Sarma and M. Albert Thomas},
abstract={Conventional magnetic resonance spectroscopic imaging requires long acquisition times. Echo planar spectroscopic imaging (EPSI) significantly reduces the scan time but is limited by conventional phase encoding. Non-uniform sampling and compressed sensing (CS) reconstruction can further accelerated 3D EPSI. We applied a Perona-Malik (PM) non-linear diffusion algorithm for CS reconstruction of 3D EPSI data in both retrospectively and prospectively undersampled phantom and in-vivo data sets and compared results with those using Total Variation (TV). Our pilot findings demonstrate that PM produces improved reconstruction results compared to TV. Furthermore, PM eliminates the need for parameter tuning, giving it a great advantage over TV.}
}
@inproceedings{ISMRM2018_3844,
annote={ISMRM2018_3844},
pages={3844},
file={ISMRM2018_3844.pdf:ISMRM2018_3844.pdf:PDF},
title={Fast Irregular {MRSI} spiral acquisition for sparse spectra. Application to 31P {MRSI} in muscles.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3844.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jabrane Karkouri and Fabien Millioz and Magalie Viallon and Rémy Prost and Hélène Ratiney},
abstract={Magnetic resonance spectroscopic imaging (MRSI) has multiple interests in clinical practice but it faces quite long acquisition time in practice which limits its use in a clinical environment. In this work, a new fast Magnetic Resonance Spectroscopic image acquisition method, inspired by Compressed Sensing using the a priori known sparse support of the metabolites chemical shift, is introduced and evaluated based on a k-t space spiral sampling. In the proposed method, the spatial and temporal interleaves are both taken in consideration during the implementation, in order to reach an even faster acquisition. This method has been evaluated using real in vivo 31P data.}
}
@inproceedings{ISMRM2018_3845,
annote={ISMRM2018_3845},
pages={3845},
file={ISMRM2018_3845.pdf:ISMRM2018_3845.pdf:PDF},
title={Residual water signal removal in {MR} spectroscopic imaging with L2 regularization},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3845.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Liangjie Lin and Michal Považan and Adam Berrington and Zhong Chen and Peter B. Barker},
abstract={Residual water signals in MRSI data may hinder the quantification of metabolite signals and thus affect the quality of final metabolite maps. A L2 regularization based post-processing method is proposed here for efficient removal of residual water signals especially in MRSI data. Using a water-basis matrix, the proposed method aims to find spectra that match the original metabolite signals, but at the same time imposes a constraint of reduced water signals. Results show that the L2 regularization based method can be a highly effective way for removing residual water signals from MRSI data of human brain.}
}
@inproceedings{ISMRM2018_3846,
annote={ISMRM2018_3846},
pages={3846},
file={ISMRM2018_3846.pdf:ISMRM2018_3846.pdf:PDF},
title={High Resolution Semi-{LASER} Localized Echo Planar Spectroscopic Imaging at Ultra High Field},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3846.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Eduardo Coello and Ralph Noeske and Brian L. Burns and Jeremy W. Gordon and Angela Jakary and Bjoern Menze and Axel Haase and Peder E.Z. Larson and Yan Li and Rolf F. Schulte},
abstract={This work presents a robust framework for fast high-resolution
1H MRSI at 7 Tesla using semi-localized by adiabatic selective refocusing (semi-LASER) and high-bandwidth symmetric echo planar spectroscopic imaging (EPSI). Inconsistencies in the symmetric EPSI trajectory are corrected using a single shot water reference scan, effectively removing spectral ghosting. With the proposed methodology, high-resolution metabolite ratio maps that show correlation with anatomical structures were obtained under 5-minutes.}
}
@inproceedings{ISMRM2018_3847,
annote={ISMRM2018_3847},
pages={3847},
file={ISMRM2018_3847.pdf:ISMRM2018_3847.pdf:PDF},
title={Whole Brain 5mm-isotropic 3D 1H-{FID}-{MRSI} accelerated with Compressed-Sensing {SENSE}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3847.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Antoine Klauser and Sebastien Courvoisier and Michel Kocher and Dimitri Van De Ville and Francois Lazeyras},
abstract={Proton FID-MRSI sequence was implemented in 3D to measure metabolite distributions over whole brain up to 5mm-isotropic resolution. MRSI dataset was reconstructed through a Low-Rank-TGV model enabling Compressed-sensing SENSE acceleration. Acceleration performance was assessed quantitatively on a-posteriori 6.6mm-isotropic dataset showing good agreement up to a factor 2. As proof of concept, metabolite images of a 5mm-isotropic dataset accelerated by a factor 2 were acquired and reconstructed.}
}
@inproceedings{ISMRM2018_3848,
annote={ISMRM2018_3848},
pages={3848},
file={ISMRM2018_3848.pdf:ISMRM2018_3848.pdf:PDF},
title={Effect of the phase variation induced by eddy currents on localized spectroscopy fatty acid composition quantification and its correction},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3848.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Angéline Nemeth and Benjamin Leporq and Amandine Coum and Giulio Gambarota and Kévin Seyssel and Bérénice Segrestin and Pierre-Jean Valette and Martine Laville and Olivier Beuf and Hélène Ratiney},
abstract={Monte Carlo simulations and in vivo measurements on human abdominal adipose tissue were used to analyze the effect of the phase variation induced by eddy currents on localized spectroscopy fatty acid composition quantification (proportion of polyunsaturated, monounsaturated and saturated fatty acid). Monte Carlo simulations showed that base line distortions were able to strongly impact estimation of fatty acid composition. So we proposed a simple method to correct the base line using a second signal acquired with a longer TE. Test-retest variability of quantitative results was reduced using this correction.}
}
@inproceedings{ISMRM2018_3849,
annote={ISMRM2018_3849},
pages={3849},
file={ISMRM2018_3849.pdf:ISMRM2018_3849.pdf:PDF},
title={IceVespa: Automated Inline {MR} Spectral Processing and Fitting on the Clinical Platform},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3849.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Brian J Soher and James Joers and Dinesh Deelchand and Gulin Oz},
abstract={The IceVespa module is a flexible add-in functor for the Siemens IceProgramF ICE pipeline for MRS data. Raw MRS data is sent to a Python-based Vespa-Analysis spectral processing node via an XML-RPC client/server. Graphical and tabular spectral analysis fitting results are returned to the ICE pipeline and saved in the standard DICOM workflow. Analysis executes in its own process. XML-RPC was chosen for inter-process communication for its simplicity and flexibility for relocating the processing node using standard HTTP protocols. Combining Python-based IceVespa inline with standard C++ ICE processing increases processing algorithm choice while maintaining clinical access to quantitative MRS measures.}
}
@inproceedings{ISMRM2018_3850,
annote={ISMRM2018_3850},
pages={3850},
file={ISMRM2018_3850.pdf:ISMRM2018_3850.pdf:PDF},
title={Analysis Methods for Human Hyperpolarized 13C-pyruvate Studies},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3850.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Peder Eric Zufall Larson and Hsin-Yu Chen and Jeremy W. Gordon and John Maidens and Daniele Mammoli and Mark Van Criekinge and Robert Bok and Rahul Aggarwal and Marcus Ferrone and James B. Slater and John Kurhanewicz and Daniel B. Vigneron},
abstract={A major challenge for human Hyperpolarized 13C metabolic MRI is to develop informative, accurate and robust methods for measuring metabolic conversion, while accounting for a broad range of experimental characteristics and without gold-standard experiments for evaluating accuracy and precision. We present a simulation framework to evaluate analysis strategies and show that an “input-less” kPL fitting method is a promising approach for accurate and robust measurements of metabolism in human hyperpolarized 13C-pyruvate MRI. We evaluate this method in human prostate cancer studies, where we observed variability of ±5-10s in the bolus delivery that can lead to errors in other analysis methods.}
}
@inproceedings{ISMRM2018_3851,
annote={ISMRM2018_3851},
pages={3851},
file={ISMRM2018_3851.pdf:ISMRM2018_3851.pdf:PDF},
title={{MRSI} Brain Temperature Mapping Using Machine Learning},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3851.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Dhritiman Das and Michael J Thrippleton and Scott IK Semple and Rolf F Schulte and Mike E Davies and Bjoern H Menze and Ian Marshall},
abstract={We propose a machine-learning framework for brain temperature estimation in MRSI using human in-vivo data from 1.5T and 3T scanners. We consider the chemical-shift based method as our benchmark and compare our results against it. Our framework, based on random-forest regression, performs a K-fold cross validation on the MRSI dataset which includes (1) learning the spectral features (including the chemical-shift) from the subjects; (2) obtaining brain temperature estimates and computing the error over the corresponding jMRUI-fitted chemical-shift based estimates. Compared to jMRUI, our method, after training, gives a low estimation error and a 30-fold improvement in estimation speed per patient.}
}
@inproceedings{ISMRM2018_3852,
annote={ISMRM2018_3852},
pages={3852},
file={ISMRM2018_3852.pdf:ISMRM2018_3852.pdf:PDF},
title={Direct Estimation of Model Parameters in {MR} Spectroscopic Imaging using Deep Neural Networks},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3852.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Dhritiman Das and Eduardo Coello and Anjany Sekuboyina and Rolf F Schulte and Bjoern H Menze},
abstract={We introduce a deep neural-network framework based on a multilayer perceptron for estimation of the output parameters of a model-based analysis of MR spectroscopy data. Our proposed framework: (1) learns the spectral features from a training set comprising of different variations of synthetic spectra; (2) uses this learning and performs non-linear regression for the subsequent metabolite quantification. Experiments involve training and testing on simulated and in-vivo human brain spectra. We estimate parameters such as metabolite-concentration ratios and compare our results with that from the LCModel.}
}
@inproceedings{ISMRM2018_3853,
annote={ISMRM2018_3853},
pages={3853},
file={ISMRM2018_3853.pdf:ISMRM2018_3853.pdf:PDF},
title={Spatially localized pure shift 1H {MRS} for biological tissues at 7 T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3853.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yuqing Huang and Weinan Lai and Zhong Chen},
abstract={Proton magnetic resonance spectroscopy (
1H MRS) presents an effective tool for in vivo studies on biological tissues by the non-invasive detection manner. However, due to limited proton chemical shift range and extensive J coupling splittings, spectral congestions or even overlapping are generally encountered in resulting 1D
1H MRS acquired by routine STimulated Echo Acquisition Mode (STEAM) and Point resolved spectroscopy (PRESS) experiments. In this report, we presents a previously-unreported MAS approach to obtain spatially localized 1D pure shift spectra with spectral simplification, potentially useful for studies on biological samples.}
}
@inproceedings{ISMRM2018_3854,
annote={ISMRM2018_3854},
pages={3854},
file={ISMRM2018_3854.pdf:ISMRM2018_3854.pdf:PDF},
title={{HOPE} (Half-intensity with macrOmolecule-suPprEssion): Ultra-short {TE} {MRS} without macromolecules on 3 T, 4 T and 9.4 T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3854.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Xi Chen and Yihong Yang and Dost Ongur and Fei Du},
abstract={The strong and overlapping macromolecule (MM) signals remains as one of the major technical challenges for metabolites quantification using ultra-short TE MRS. HOPE (Half-intensity with macrOmolecule-suPprEssion), a simple but effective MM suppression MRS method based on SPECIAL, was proposed and tested on human 3T, 4T and animal 9.4T. HOPE has no additional pulse or cycling compared to SPECIAL but with the same short TE. With the similar SNR level as STEAM, HOPE achieves additional benefit with substantial suppression of MM signals and more accurate quantifications of MM overlapped metabolites such as lactate and GABA.}
}
@inproceedings{ISMRM2018_3855,
annote={ISMRM2018_3855},
pages={3855},
file={ISMRM2018_3855.pdf:ISMRM2018_3855.pdf:PDF},
title={Intra- and inter-site reproducibility of single voxel {MRS} at 3T in the human brain},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3855.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Carina Graf and Erin L MacMillan and Eric Fu and Irene M Vavasour and Trudy Harris and Burkhard Mädler and Anthony Traboulsee and David KB Li and Alex MacKay and Cornelia Laule},
abstract={We investigated the intra- and inter-site reproducibility of 1H-MRS with short-TE PRESS at 3T acquired on a single manufacturer at 6 different sites. Metabolite concentrations were robust to small inconsistencies in voxel placement (mean alignment=86\%), highlighting that site was not the driving factor for differences in metabolite concentrations. Between-subject differences drove the concentration variability for creatine, choline and myoinositol (42-65\% of the variance). The mean intra-site coefficient of variation for the metabolites was between 2.5\% and 5.3\%. The results support the use of a large single voxel 1H-MRS acquisition from a single manufacturer for multi-site clinical trials.}
}
@inproceedings{ISMRM2018_3856,
annote={ISMRM2018_3856},
pages={3856},
file={ISMRM2018_3856.pdf:ISMRM2018_3856.pdf:PDF},
title={Eddy current evaluation and minimization for {PRESS} localized diffusion tensor spectroscopy.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3856.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Chris Hanstock and Christian Beaulieu},
abstract={Gradients used for diffusion spectroscopy require minimization of the eddy currents. Eddy currents impact phase alignment, spectral distortion and signal amplitude, contributing to error in estimating diffusion coefficients. Strategies have been employed to minimize their effects, including using bipolar gradient pulses around the MRS volume selective pulses. This concept has been further refined to allow multiple eddy current time constants to be minimized by using asymmetric bipolar gradient pairs. An additional oscillatory eddy current may arise as the result of vibration and acoustic noise. We present a simple method for assessing and minimizing the oscillatory eddy currents.}
}
@inproceedings{ISMRM2018_3857,
annote={ISMRM2018_3857},
pages={3857},
file={ISMRM2018_3857.pdf:ISMRM2018_3857.pdf:PDF},
title={Evaluation of accuracy and reproducibility of 1H {MRS} measurements of lactate at 7 T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3857.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Masoumeh Dehghani and Kim Q. Do and Pierre Magistretti and Lijing Xin},
abstract={
Lactate is known as an end-product of aerobic glycolysis and it has been considered as a potential biomarker of metabolic abnormalities occurred in different cerebral pathological states. However, the1H MRSdetection of lactate is hampered by the presence of co-resonant lipid and macromolecule resonances. The aim of this study was to evaluate the performance of different 1H MRS protocols appliedin semi-adiabatic spin-echo full-intensity acquired localized spectroscopy sequence,I) TE=16 ms, no inversion, II) TE=16 ms, TI= 300 ms and III) TE=110 ms, no inversion in reliable detection oflactatein the brain using in vivo measurement and simulated spectra at different experimental condition.The in vivo measurement and simulation analysis suggests thatshort-TE 1H MRS approach without inversion pulse is likely to be a more reliable method for estimating the absolute concentration of lactate and other metabolites simultaneously from the human brain.
}
}
@inproceedings{ISMRM2018_3858,
annote={ISMRM2018_3858},
pages={3858},
file={ISMRM2018_3858.pdf:ISMRM2018_3858.pdf:PDF},
title={Quantification and Assessment of T2 Relaxation Times of Human Bile Components with In Vivo {MR} Spectroscopy at 7T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3858.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Martin Gajdošík and Marek Chmelík and Emina Halilbasic and Lorenz Pfleger and Michael Trauner and Siegfried Trattnig and Martin Krššák},
abstract={In vivo measurements of concentrations of bile components are of high interest for understanding and diagnosis of cholestatic diseases. We measured human bile in the gallbladder in vivo using single-voxel 1H-MR spectroscopy at 7T and assessed T2 relaxation times of water and eight bile components in healthy volunteers. With precise T2 correction, all eight bile components could be quantified with ultra-short TE sequence and four with long TE sequence.}
}
@inproceedings{ISMRM2018_3859,
annote={ISMRM2018_3859},
pages={3859},
file={ISMRM2018_3859.pdf:ISMRM2018_3859.pdf:PDF},
title={A 3 Minute Clinical Protocol for Quantitative High-Speed {MR} Spectroscopic Imaging in Patients with Brain Tumors},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3859.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Troy Hutchins-Delgado and Mohammad Omar Chohan and Kevin Tagne Fotso and Lakshmisree Damodaran and Howard Yonas and Mona D Chaney and Stefan Posse},
abstract={We develop a quantitative 3-minute 3D short echo-time (TE) proton-echo-planar-spectroscopic-imaging (PEPSI) protocol. The short scan time is made possible by using partial brain coverage that encompasses the tumor and integration of the water reference (WR) scan into the water suppression module, which enables short repetition time. The method was validated in 5 healthy controls and applied to mapping tumor margins and infiltration in 3 patients with brain tumors. Slab-averaged metabolite/water ratios varied by less than 10\% between healthy controls and metabolite concentration values after partial volume and relaxation correction were in the range of our previous study.}
}
@inproceedings{ISMRM2018_3860,
annote={ISMRM2018_3860},
pages={3860},
file={ISMRM2018_3860.pdf:ISMRM2018_3860.pdf:PDF},
title={Assessment of metabolic heterogeneity in glioblastoma multiforme ({GBM}) through histogram analysis of whole-brain echo planar spectroscopic imaging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3860.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Gaurav Verma and Sanjeev Chawla and Suyash Mohan and Sumei Wang and Rebecca Emily Feldman and MacLean Nasrallah and Steven Brem and Donald O'Rourke and Harish Poptani and Priti Balchandani},
abstract={Glioblastoma multiforme (GBM) is an infiltrating and heterogeneous disease with low median survival and over 70\% recurrence rates, though 20-30\% of progressive enhancing lesions seen in GBM post-treatment exhibit pseudoprogression rather than true recurrent tumor. Differentiating these could improve speed and accuracy of treatment. A statistical and histogram analysis of segmented high-resolution echo-planar spectroscopic imaging data goes beyond mean metabolite ratios to show distribution of Cho/NAA and Cho/Cr ratios in contrast enhancing regions and the surrounding tissue. Cho/NAA distribution in enhancing region showed greater kurtosis than Cho/Cr, suggesting reduction in NAA may be a driving factor in observed Cho/NAA increases.}
}
@inproceedings{ISMRM2018_3861,
annote={ISMRM2018_3861},
pages={3861},
file={ISMRM2018_3861.pdf:ISMRM2018_3861.pdf:PDF},
title={Cross-validated full-field of view {MRSI} using a new spatial lipid extraction technique and {HSVD} and {PG} algorithms in the human brain.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3861.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Peter Adany and In-Young Choi and Phil Lee},
abstract={Reliable 1H MRS measurement in the brain is challenging due to strong lipid signals as high as two orders of magnitude stronger than metabolites. We propose a new spatial-domain post processing technique to extract the lipid signal and compare our method with the HSVD and PG algorithms applied to full field of view (FOV) MRSI data (no lipid nulling, no outer volume suppression). Results of lipid removal were assessed visually and by spectral quantification of MRSI voxels for N=9 subjects. Our method outperformed HSVD and PG and achieved reliable full-FOV MRSI, promising to reach the maximum potential of whole-brain MRSI.}
}
@inproceedings{ISMRM2018_3862,
annote={ISMRM2018_3862},
pages={3862},
file={ISMRM2018_3862.pdf:ISMRM2018_3862.pdf:PDF},
title={High resolution 3D {EPSI} Spectroscopic Imaging compared with Spectral Localization by Imaging ({SLIM})},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3862.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Sean Edmund Ellis and Peter Adany and Phil Lee and In-Young Choi},
abstract={Quantitative measurements of metabolites in important structures in the human brain are challenging to acquire using conventional spectroscopic imaging methods. In this study, we compared regional metabolite concentrations obtained from high resolution 3D EPSI MRSI data using two different methods: spatial averaging inside regions of interest using the MIDAS software and Spectral Localization by Imaging (SLIM)-based MRS. Deep brain structures were studied and compared using the two methods. The quantitative outcomes of 3D EPSI and SLIM were comparable and SLIM could provide metabolite concentrations using shorter scan times by reducing the required number of voxel acquisitions.}
}
@inproceedings{ISMRM2018_3863,
annote={ISMRM2018_3863},
pages={3863},
file={ISMRM2018_3863.pdf:ISMRM2018_3863.pdf:PDF},
title={{MRSI}-based characterization of {GBM} using a novel map: Expected Distance to Tumor ({EDT})},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3863.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Nuno Pedrosa de Barros and Raphael Meier and Samuel Stettler and Urspeter Knecht and Evelyn Herrmann and Philippe Schucht and Mauricio Reyes and Jan Gralla and Roland Wiest and Johannes Slotboom},
abstract={MRSI can detect regions of brain tumor infiltration beyond the tumor borders visible in structural-MRI (sMRI). However, this is often achieved using only a small fraction of the information provided by MRSI, namely Cho/NAA maps only. Here, we present a new machine-learning-based approach that translates the multidimensional information provided by each spectrum into a single measure: the Expected Distance to solid Tumor volume visible in sMRI. The results show that peritumoral spectra carry information on the distance to solidtumor and that EDT maps may improve the characterization of peritumoral tissue changes invisible with structural MRI.
}
}
@inproceedings{ISMRM2018_3864,
annote={ISMRM2018_3864},
pages={3864},
file={ISMRM2018_3864.pdf:ISMRM2018_3864.pdf:PDF},
title={Assessment of Bound Sodium using Triple Quantum Selection vs. Inversion Recovery at 21.1 T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3864.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Nastaren Abad and Ghoncheh Amouzandeh and Jens T. Rosenberg and Michael G. Harrington and Samuel Colles Grant},
abstract={This study evaluates Triple Quantum (TQ) and Inversion Recovery (IR) techniques at 21.1 T with regards to bound sodium quantification. Using both gel phantoms imitating physiological concentrations/bound fractions as well as in vivo animal pathological models, the efficiency, SNR and selectivity of
23Na TQ and IR techniques were compared with the ultimate goal of localizing specific sodium changes within intra- and extracellular compartments related to disease progression.}
}
@inproceedings{ISMRM2018_3865,
annote={ISMRM2018_3865},
pages={3865},
file={ISMRM2018_3865.pdf:ISMRM2018_3865.pdf:PDF},
title={Investigating Bound Sodium Signals using a Novel Chemical Shift Imaging Triple Quantum Technique},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3865.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Nastaren Abad and Ghoncheh Amouzandeh and Jens T. Rosenberg and Michael G. Harrington and Samuel Colles Grant},
abstract={
23Na-based MRI techniques can be used to separate sodium signal originating from the extracellular and intracellular compartments. Triple Quantum (TQ) schemes can select the coherence pathway that evolves in slow moving/restricted regimes, such as in the intracellular compartment. In this study, a novel TQ technique based on a modified chemical shift imaging sequence (CSI-TQ), which yields higher signal-to-noise ratios, is introduced for studies at 21.1 T. The CSI-TQ is compared to a more conventional gradient recalled echo variant (GRE-TQ) with respect to SNR and efficiency.}
}
@inproceedings{ISMRM2018_3866,
annote={ISMRM2018_3866},
pages={3866},
file={ISMRM2018_3866.pdf:ISMRM2018_3866.pdf:PDF},
title={Simultaneously Acquired Single- and Triple-Quantum Spectroscopic Imaging with Density-Adapted Projection Reconstruction and Time Proportional Phase Increment},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3866.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ruomin Hu and Matthias Malzacher and Michaela A U Hoesl and Dennis Kleimaier and Lothar R Schad},
abstract={Multi-quantum filtered spectroscopic imaging methods utilize the spin-3/2 characteristic of
23Na nuclei to generate multi-quantum coherences reflecting on the binding of
23Na
+ to macromolecules. In this work, a spectroscopic density-adapted radial imaging modality was developed to simultaneously acquire single-quantum and triple-quantum signal under identical condition using time proportional phase increments. In vivo rat head images with 1 mm resolution were acquired in under an hour. This method may be applied to monitor the single-quantum and triple-quantum signal development in diseases such as stroke and cancer and lead to a deeper understanding of metabolic processes in healthy and diseased tissue.}
}
@inproceedings{ISMRM2018_3867,
annote={ISMRM2018_3867},
pages={3867},
file={ISMRM2018_3867.pdf:ISMRM2018_3867.pdf:PDF},
title={Sodium imaging with an {UTE} technique to study the effects of exercise on muscle.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3867.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Benjamin L Prestwich and Charlotte E Buchanan and Andrew P Hale and Andrew M Peters and Susan T Francis},
abstract={Sodium (
23Na) imaging can provide insight into the effects of exercise on muscle. Here we perform a 3D dual TE UTE scheme with radial FID readout to assess the alterations in sodium tissue concentration in the gastrocnemius and soleus muscles; immediately after exercise performed inside the scanner using a Trispect pedal system. In addition an mDIXON proton scan was acquired for delineation of the muscle groups. Following exercise, the time course of the
23Na signal intensity in the medial gastrocnemius and soleus muscles was found to return to baseline after approximately 30 minutes, with a 10 – 20 \% signal change.}
}
@inproceedings{ISMRM2018_3868,
annote={ISMRM2018_3868},
pages={3868},
file={ISMRM2018_3868.pdf:ISMRM2018_3868.pdf:PDF},
title={Design of a Dual Saddle Coil Setup for High Resolution 1H/23Na {MRI} of Ex Vivo Rat Tail Intervertebral Discs at 14.1T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3868.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Lance Tyler Williams and John Edward Clark and Lukas Neuberger and Gangchea Lee and Daniel H. Cortes and Thomas Neuberger},
abstract={Rat-tail intervertebral disc puncture is a commonly used model for studying treatment options and the pathology of Degenerative Disc Disease (DDD). However, longitudinal studies are impossible as analysis through biochemistry and histology requires euthanization. High-field MRI provides a possible solution to this problem as initial structural and compositional changes related to disc degeneration are observable. In this work, a dual saddle coil was constructed for 1H/23Na imaging at 14.1T. It was concluded from ex vivo rat-tail proton and sodium images that sodium MRI is feasible and it could be an effective method for rat-tail intervertebral disc degeneration evaluation.}
}
@inproceedings{ISMRM2018_3869,
annote={ISMRM2018_3869},
pages={3869},
file={ISMRM2018_3869.pdf:ISMRM2018_3869.pdf:PDF},
title={Effect of B0 and B1 Field Inhomogeneity Correction on Region-of-Interest Analysis on 3T Sodium 23Na-{MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3869.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Elaine H Lui and Vijay Venkatraman and Christopher Steward and Tie-Qiang Li and Patricia M Desmond},
abstract={Evaluation of the effect of B0 and B1 correction on region-of-interest (ROI) analysis in forty-one 3T brain 23Na-MRI scans shows average change from B0, B1 and B0B1 correction of 1.0\% (p=0.05), -3.7\% (p<0.001) and -4.7\% (p<0.001) respectively. Effect is more for B1 than B0 correction and depending on the anticipated effect size of the neurologic disease of interest, B0 +/- B1 correction may not be required, potentially reducing scan time by 66\% and thus encourage quantitative 23Na-MRI research in a clinical environment.}
}
@inproceedings{ISMRM2018_3870,
annote={ISMRM2018_3870},
pages={3870},
file={ISMRM2018_3870.pdf:ISMRM2018_3870.pdf:PDF},
title={Double quantum filtered 23Na {MRI} with magic angle excitation in presence of B0-inhomogeneities},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3870.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Lena V. Gast and Bernhard Hensel and Michael Uder and Armin M. Nagel},
abstract={In
23Na MRI it is possible to selectively detect signal from sodium ions bound to anisotropic structures by applying a double quantum filter with magic angle excitation (DQ-MA). In this work, the influence of B
0-inhomogeneities on the DQ-MA filtering capacity was examined both theoretically and experimentally. We found that under practical conditions (|ΔB
0| ≈ 50 Hz at 3T) a significant amount of unwanted odd rank double quantum coherence signal may pass the filter even in case of perfect magic angle excitation. Therefore, B
0-inhomogeneities may cause an over-estimation of the degree of anisotropy.}
}
@inproceedings{ISMRM2018_3871,
annote={ISMRM2018_3871},
pages={3871},
file={ISMRM2018_3871.pdf:ISMRM2018_3871.pdf:PDF},
title={Investigating the 23Na Flip-Angle Effect in Cartilage, Skin and Muscle},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3871.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Atefeh Kordzadeh and Jade Duchscherer and Christian Beaulieu and Robert Stobbe},
abstract={The measurement of sodium concentration in cartilage, skin and muscle with
23Na MRI requires the knowledge and minimization of spin 3/2-related signal losses. Here, a common B
1 mapping experiment is used here to show that greater than prescribed flip-angles are produced in healthy human cartilage, skin and muscle and that this effect is increased with longer RF excitation pulses. This points to the presence of residual quadrupole interactions in these tissues. To avoid the concomitant signal loss associated with residual quadrupole interactions, very hard (short) RF excitation pulses may be required.}
}
@inproceedings{ISMRM2018_3872,
annote={ISMRM2018_3872},
pages={3872},
file={ISMRM2018_3872.pdf:ISMRM2018_3872.pdf:PDF},
title={Improved Encoding Efficiency in Sodium {MRI} with Zero-Gradient-Excitation Ramped Hybrid Encoding (z{GRF}-{RHE})},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3872.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yasmin Blunck and Bradford A Moffat and Scott C Kolbe and Roger J Ordidge and Jon O Cleary and Leigh A Johnston},
abstract={The fast signal decay in sodium MRI makes high quality image acquisition challenging. Here we enhance image quality by improving encoding time (t
enc) efficiency using a special case of ramped hybrid encoding , zero-gradient-under-RF-excitation RHE (zG
RF-RHE). This provides 1) gradient-free-excitation for high flip angle, non-selective excitation profiles necessitated by low signal in sodium MRI and 2) gradient ramping during deadtime for optimised t
enc, to reduce T2 decay influence during acquisition. The performance of zG
RF-RHE is demonstrated in simulations, phantom and in vivo experiments and improves image quality (SNR and T2 blurring). It is applicable to any centre-out trajectory design.}
}
@inproceedings{ISMRM2018_3873,
annote={ISMRM2018_3873},
pages={3873},
file={ISMRM2018_3873.pdf:ISMRM2018_3873.pdf:PDF},
title={Influence of motion and partial volume effects on measured tissue sodium concentration in cardiac $^{23}$Na {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3873.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Johanna Lott and Jonathan M. Lommen and Sebastian C. Niesporek and Tanja Platt and Nicolas G.R. Behl and Mark E. Ladd and Armin M. Nagel},
abstract={Sodium (
23Na) ions are involved in many biological processes. The tissue sodium concentration can be determined with
23Na MRI; however, fast relaxation times, breathing and heart motion as well as the high sodium concentration of blood render quantitative determination of the myocardial sodium concentration challenging. We present a method to analyze the tissue sodium concentration within the myocardium by utilizing a partial volume correction as well as correction of motion effects. The presented workflow can reduce the bias by up to 49\%.}
}
@inproceedings{ISMRM2018_3874,
annote={ISMRM2018_3874},
pages={3874},
file={ISMRM2018_3874.pdf:ISMRM2018_3874.pdf:PDF},
title={Voxel localization for sodium {NMR} triple-quantum signal; sequence design and test in agarose phantoms and in-vivo rat},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3874.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Michaela A U Hoesl and Dennis Kleimaier and Matthias Malzacher and Ruomin Hu and Lothar R Schad},
abstract={The TQTPPI – sequence is a global spectroscopic method, which can be used to study the sodium metabolism of cells in-vitro with the foremost interest in the occurrence of the triple-quantum signal. This spectroscopic analysis could offer precise knowledge of sodium metabolic processes in pathology versus healthy tissue. To address clinical questions, we aim for transferring this method to in-vivo patient acquisitions where the need for a localization arises. Two different localization strategies, which preserve the quantum coherences, were successfully implemented and tested in-vitro and in-vivo on a rat using a 9.4T small-animal scanner.}
}
@inproceedings{ISMRM2018_3875,
annote={ISMRM2018_3875},
pages={3875},
file={ISMRM2018_3875.pdf:ISMRM2018_3875.pdf:PDF},
title={Can sodium triple-quantum signal separate extra- and intracellular signals? – investigation on {HEP} G2 liver cells, liposomes and nanoparticles},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3875.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Michaela A U Hoesl and Dennis Kleimaier and Ruomin Hu and Matthias Malzacher and Eric Gottwald and Cordula Nies and Lothar R Schad},
abstract={Sodium MRI is increasing in popularity albeit the apparent challenges of low SNR and fast bi-exponential decay. Currently, intra- and extra cellular sodium can only be resolved by introducing a chemical shift reagent which is unusable in human studies due to toxicity. There is discussion on whether triple-quantum signal (TQS) could provide a discriminator for resolving intra- and extracellular signal due to motion restriction of sodium ions within the cell. This work investigates the TQS behavior using a triple quantum sequence with time proportional phase increment (TQTPPI) on liposomes, HEP G2 liver cells and nanoparticles to disentangle the reasons for occurring TQS.}
}
@inproceedings{ISMRM2018_3876,
annote={ISMRM2018_3876},
pages={3876},
file={ISMRM2018_3876.pdf:ISMRM2018_3876.pdf:PDF},
title={Multi-pulse Sodium Magnetic Resonance Imaging for Multi-compartment Quantification in Brain at 7T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3876.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Martin Gajdošík and Alina Gilles and Ivan Kirov and Guillaume Madelin},
abstract={We propose a new approach to investigate intra- and extracellular sodium in vivo. In this preliminary study we could differentiate brain compartments and provide an estimate of intracellular and extracellular sodium concentrations as well as intracellular, extracellular and cerebrospinal fluid volume fractions.}
}
@inproceedings{ISMRM2018_3877,
annote={ISMRM2018_3877},
pages={3877},
file={ISMRM2018_3877.pdf:ISMRM2018_3877.pdf:PDF},
title={Application of 3D-Dictionary Learning Compressed Sensing Reconstruction En Route to Isotropic Submillimeter Spatial Resolution Sodium (23Na) In Vivo {MRI} of the Human Eye at 7.0 Tesla},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3877.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Daniel Wenz and Nicolas G.R. Behl and Armin M. Nagel and Mark E. Ladd and Thoralf Niendorf},
abstract={Sodium ion (Na
+) is a very important factor in the physiology of the human eye. However sodium (
23Na) MRI is limited by its low sensitivity. Compressed sensing provides means to overcome this challenge. This work demonstrates the feasibility of high spatial resolution (1mm isotropic)
23Na in vivo MRI of the eye using a dedicated six-channel transceiver array in conjunction with a 3D dictionary learning compressed sensing algorithm. This approach showed distinct noise reduction along with substantial reduction in total acquisition time if benchmarked against conventional reconstruction employing standard gridding.}
}
@inproceedings{ISMRM2018_3878,
annote={ISMRM2018_3878},
pages={3878},
file={ISMRM2018_3878.pdf:ISMRM2018_3878.pdf:PDF},
title={Simulation of 13C labeling Effects of Glutamate and Glutamine in 1H {MR} Spectra with different Pulse Sequences at 9.4 T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3878.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Theresia Ziegs and Anke Henning},
abstract={Glutamate related metabolism can be measured considering the 13C labeling effects from an administered 13C labeled substrate in pure 1H MRS spectra without a 13C channel. In this work, simulated 1H MRS spectra with FID, semi-Laser and two PRESS sequences have been compared to optimize spectral resolution for glutamate and glutamine measurements at 9.4 T. Furthermore, spectral changes according to a two-compartment model were analyzed. As a result, this work indicates the fastest possible acquisition can be obtained with an FID sequence, while the best resolution possible can be obtained with a PRESS sequence.}
}
@inproceedings{ISMRM2018_3879,
annote={ISMRM2018_3879},
pages={3879},
file={ISMRM2018_3879.pdf:ISMRM2018_3879.pdf:PDF},
title={Minimum echo-time {PRESS}-localized proton observed carbon edited ({POCE}) magnetic resonance spectroscopy for rat brain imaging using simultaneous editing and localization pulses.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3879.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Chathura Kumaragamage and Dan Madularu and Axel P Mathieu and Derek Lupinsky and Robin A de Graaf and Jamie Near},
abstract={Dynamic Carbon-13 (
13C) magnetic resonance spectroscopy (MRS) remains to be the only noninvasive method capable of measuring neuroenergetics and neurotransmitter cycling in the brain
1. Proton observed carbon edited (POCE) MRS
2 is an attractive alternative to direct
13C methods due to improved signal-to-noise-ratio (SNR). This study reports a PRESS localized POCE sequence utilizing simultaneous editing and localization (SEAL-PRESS), which allows the TE to be reduced to a theoretically optimal value of ~1/J
HC (8.1ms, in this implementation). The sequence was validated in phantom and in a rat preparation and demonstrated >17\% improvement in
13C labeled metabolites relative to a 12.6-ms PRESS-POCE sequence.}
}
@inproceedings{ISMRM2018_3880,
annote={ISMRM2018_3880},
pages={3880},
file={ISMRM2018_3880.pdf:ISMRM2018_3880.pdf:PDF},
title={Evaluation of three different broadband ¹H decoupling techniques for 13C-{MRS} at high field using double-tuned array coils},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3880.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Guillaume Donati and Rolf Gruetter},
abstract={synopsis}
}
@inproceedings{ISMRM2018_3881,
annote={ISMRM2018_3881},
pages={3881},
file={ISMRM2018_3881.pdf:ISMRM2018_3881.pdf:PDF},
title={Coil Combination Methods for 16-channel Hyperpolarized
13C Spectroscopic Imaging Studies of Liver Metastases Patients},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3881.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Zihan Zhu and Xucheng Zhu and Michael Ohliger and Peng Cao and Shuyu Tang and Jeremy W Gordon and Lucas Carvajal and Peter J Shin and Rahul Aggarwal and Robert Bok and John Kurhanewicz and Pamela Munster and Peder E.Z. Larson and Daniel B Vigneron},
abstract={Effective coil combination methods for human hyperpolarized
13C spectroscopy data remain relatively unexplored. This study implemented several coil combination methods, including sum-of-squares (SOS), singular value decomposition (SVD) and pyruvate map based sensitivity calibration (PyrMap). These methods were evaluated by both simulation and in human cancer studies. Overall, both the SVD and PyrMap methods demonstrated better accuracy and robustness than SOS and the PyrMap best preserved the phase information.}
}
@inproceedings{ISMRM2018_3882,
annote={ISMRM2018_3882},
pages={3882},
file={ISMRM2018_3882.pdf:ISMRM2018_3882.pdf:PDF},
title={The effects of iodinated {CT} contrast agent on phosphorus {MRS}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3882.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ladislav Valkovic and Justin YC Lau and Ines Abdesselam and Oliver Rider and Damian J Tyler and Christopher T Rodgers and Jack JJJ Miller},
abstract={Contrast-enhanced CT examination can influence
1H-MRI measurements performed within 24h after the CT scan, due to a reduction in water T
1 and T
2 caused by the iodinated contrast agents used in CT. We have investigated whether contrast from a previous CT examination would also influence metabolic measurements made using
31P-MRS, by measuring the T
1 of
1H and
31P signals in human blood. We find that iodinated CT contrast agent has no effect on phosphorus T
1s. Therefore,
31P-MRS examinations will not be influenced by prior CT (unlike
1H-MRI scans).}
}
@inproceedings{ISMRM2018_3883,
annote={ISMRM2018_3883},
pages={3883},
file={ISMRM2018_3883.pdf:ISMRM2018_3883.pdf:PDF},
title={In vivo 31P {MRI} at 7 Tesla in humans using a 3D spectrally selective {SSFP} sequence and {TPI} k-space sampling.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3883.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Arthur Coste and Sandro Romanzetti and Denis Le Bihan and Cécile Rabrait-Lerman and Fawzi Boumezbeur},
abstract={Spectrally selective
31P MRI can be of interest for the study of brain energetics for clinical research. Using a 3D SSFP sequence with non-Cartesian Twisted Projection Imaging sampling, we obtained whole-brain images of ATP and PCr in healthy volunteers at 7 Tesla with a higher normalized SNR than with CSI. Local concentration quantification was performed using the phantom replacement approach after accounting for the T
1/T
2-weighting and the transmission and reception profiles of our coil yielding consistent results.}
}
@inproceedings{ISMRM2018_3884,
annote={ISMRM2018_3884},
pages={3884},
file={ISMRM2018_3884.pdf:ISMRM2018_3884.pdf:PDF},
title={Retrospective frequency correction for fluorine (19F) {MRS} using an external reference},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3884.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Chu-Yu Lee and In-Young Choi and Jean C Dinh and William M Brooks and Steven J Leeder and Phil Lee},
abstract={Fluorine MR Spectroscopy (
19F MRS) allows in vivo quantification of fluorine-containing antipsychotic and antidepressant drug concentrations in the brain. To detect the low concentration of the drugs (~ 5-30 µM) in the brain, it requires multiple repeated acquisitions to increase SNR and the scan time is relatively long. Therefore, it is important to ensure consistent frequency alignment across the repeated acquisitions. However, MR system instability induces drifts of the scanner frequency, particularly following MR scans with a high gradient duty cycle. Previous frequency correction methods for
1H MRS require internal reference signals, such as under- or un-suppressed water and cannot be applied to
19F MRS, where the SNR of
19F signals is low at each repeated acquisition. The purpose of this study is to investigate the feasibility of using an external reference for retrospective frequency correction in
19F MRS.}
}
@inproceedings{ISMRM2018_3885,
annote={ISMRM2018_3885},
pages={3885},
file={ISMRM2018_3885.pdf:ISMRM2018_3885.pdf:PDF},
title={Measurement of oxygen consumption in a high density 3D cell culture on chip by 19F spectroscopy},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3885.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Dennis Kleimaier and Michaela Hoesl and Andreas Neubauer and Matthias Malzacher and Cordula Nies and Eric Gottwald and Lothar Schad},
abstract={Drug-induced mitochondrial dysfunction is of major clinical interest. An NMR-compatible bioreactor system was used to investigate the oxygen consumption of HepG2 cells by measuring T
1 of perflubron. The oxygen consumption was measured by stopping the perfusion. This resulted in a reduction of the oxygen concentration from (19.29 ± 0.96)\% to (11.41 ± 0.92)\% in 104.24 min. Our results might allow for detecting a drug-induced mitochondrial dysfunction of cells in a well-controlled environment by using the two compartments of the bioreactor.}
}
@inproceedings{ISMRM2018_3886,
annote={ISMRM2018_3886},
pages={3886},
file={ISMRM2018_3886.pdf:ISMRM2018_3886.pdf:PDF},
title={Low Intensity Spectral Peaks Reconstruction with Weighted Nuclear Norm Minimization on Low Rank Hankel Matrix},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3886.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Di Guo and Xiaofeng Du and Yu Yang and Meijing Lin and Xiaobo Qu},
abstract={To speed up the acquisition time of multi-dimensional magnetic resonance spectroscopy (MRS), one typical way is to sparsely acquire free induction decay (FID) data reconstruct the spectrum from the incomplete observations. Recently, a low rank Hankel matrix (LRHM) approach, that explores the sparse number of spectral peaks, has shown great ability to reconstruct the spectrum. When the data are highly undersampled, however, low intensity spectral peaks are compromised in the reconstruction. In this abstract, a weighted LRHM approach is proposed. A weighted nuclear norm is introduced to better approximate the rank constraint and a prior signal space is estimated from the pre-reconstruction to reduce the number of unknowns in reconstruction. Results on both synthetic and real MRS data demonstrate that the proposed approach can reconstruct low intensity spectral peaks better than the state-of-the-art LRHM method.}
}
@inproceedings{ISMRM2018_3887,
annote={ISMRM2018_3887},
pages={3887},
file={ISMRM2018_3887.pdf:ISMRM2018_3887.pdf:PDF},
title={Quintuple tuned coil configuration for multi-nuclear metabolic {MRI} at 7 tesla},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3887.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Tijl van der Velden and Anh Pham and Carel van Leeuwen and Debra Rivera and Mark Gosselink and Dennis Klomp},
abstract={Metabolic and anatomic imaging by combining X-nuclei imaging with
1H imaging has shown great potential in clinical research. Traditional multi-nuclear coil setups are however limited to 2 or 3 frequencies and often birdcage for
1H. In this study we propose a coil array setup tuned for acquiring 5 different nuclei in a single scan session practically without compromising efficiency on any nuclei.
}
}
@inproceedings{ISMRM2018_3888,
annote={ISMRM2018_3888},
pages={3888},
file={ISMRM2018_3888.pdf:ISMRM2018_3888.pdf:PDF},
title={Probing alterations of cellular metabolism in a mouse model of Huntington’s disease (R6/1) using in vivo {MRS} and {DW}-{MRS}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3888.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Clémence Ligneul and Edwin Hernandez-Garzon and Marco Palombo and Julien Flament and Julien Valette},
abstract={Huntington’s disease is a genetic neurodegenerative disorder caused by the abnormal repetition of the CAG triplet in the gene coding for huntingtin (Htt). R6/1 mouse model, expressing a human form of mutated huntingtin, exhibits a progressive neuronal alteration in the striatum. We use in vivo MRS and diffusion-weighted MRS at various diffusion-weightings and diffusion times to detect changes in cellular metabolic content and structure R6/1 mice striatum. We report massive metabolic remodeling, especially for N-acetyl aspartate (NAA) and Glutamine (Gln), as well as changes in glutamate diffusion properties that we tentatively relate to variations in glutamate cellular compartmentation.}
}
@inproceedings{ISMRM2018_3889,
annote={ISMRM2018_3889},
pages={3889},
file={ISMRM2018_3889.pdf:ISMRM2018_3889.pdf:PDF},
title={Metabolite concentration changes associated with positive and negative {BOLD} signal in the human visual cortex: a functional magnetic resonance spectroscopy study at 7T.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3889.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yohan Boillat and Lijing Xin and Wietske Van der Zwaag and Rolf Gruetter},
abstract={The metabolite correlates of the negative BOLD signal were investigated using functional MRS and compared to the changes produced by the positive BOLD response. The participants were scanned in a 7-T MRI while passively viewing visual checkerboards. For the positive BOLD response, increases of glutamate and lactate concentrations were observed, while the negative BOLD response in a similar voxel was linked to a decrease of glutamate, lactate and GABA concentrations. This measured decrease of oxidative metabolism during the negative BOLD response suggest a reduction a glutamatergic activity in the visual cortex.}
}
@inproceedings{ISMRM2018_3890,
annote={ISMRM2018_3890},
pages={3890},
file={ISMRM2018_3890.pdf:ISMRM2018_3890.pdf:PDF},
title={Changes of brain metabolites in response to acupuncture therapy in migraine are correlated with clinical outcomes: Result from a magnetic resonance spectroscopy imaging Study},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3890.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Tao Gu and Min Chen and Ryan CN D’Arcy and Xiaowei Song},
abstract={Migraine is a common neurological disease. Acupuncture has been proven to be effective but the mechanisms remain unclear. A proton magnetic resonance spectroscopy imaging (MRSI) study was used to investigate biochemical changes in brain regions key for the transmission of pain in response to acupuncture treatment. Results showed acupuncture treatment was associated with a significantly increased NAA/Cr in bilateral thalamus in migraine patients. A strong significant correlation between NAA/Cr and headache intensity was found in thalami. Our data provided the first evidence suggesting a brain biochemical change in response to acupuncture therapy in migraine, in correlation with clinical outcomes.}
}
@inproceedings{ISMRM2018_3891,
annote={ISMRM2018_3891},
pages={3891},
file={ISMRM2018_3891.pdf:ISMRM2018_3891.pdf:PDF},
title={Synergy between probiotics and antibiotics for the treatment of chronic hepatic encephalopathy: a longitudinal in vivo 1H {MRS} study of brain metabolism.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3891.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Emmanuelle Flatt and Cristina Cudalbu and Olivier Braissant and Stefanita Mitrea and Dario Sessa and Valérie A. Mc Lin and Rolf Gruetter},
abstract={Chronic hepatic encephalopathy(HE) is a well-accepted complication of chronic liver disease(CLD) and finding the right treatment to reduce HE episodes before liver transplant remains a challenge. Both rifaximin and probiotics are currently used to reduce HE symptoms, but their precise effect on brain metabolites have never been studied. Our aims were first to assess in vivo and longitudinally the effect of the combination of probiotics and rifaximin on a rat model of chronic HE; and second to compare the results obtained to groups of non-treated/rifaximin-only treated rats.
1H-MRS at high field combined with biochemical and behavioral tests were used.}
}
@inproceedings{ISMRM2018_3892,
annote={ISMRM2018_3892},
pages={3892},
file={ISMRM2018_3892.pdf:ISMRM2018_3892.pdf:PDF},
title={Shorter apparent T
2 relaxation times of metabolites in the older human brain},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3892.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Dinesh K Deelchand and J. Riley McCarten and Laura S Hemmy and Edward J Auerbach and Małgorzata Marjańska},
abstract={The goal of this study was to compare the apparent transverse relaxation time constants (T
2) of metabolites obtained in young and older subjects in three brain regions (occipital cortex (OCC), posterior cingulate cortex (PCC) and prefrontal cortex (PFC)) using LASER at 3T. A lower apparent T
2s of N-acetyl aspartate and tissue water were measured in older adults in all three regions. T
2 for total creatine and myo-inositol were also shorter in older adults in OCC and PCC. In conclusion, differences in T
2 values of metabolites during normal brain aging are region-dependent.}
}
@inproceedings{ISMRM2018_3893,
annote={ISMRM2018_3893},
pages={3893},
file={ISMRM2018_3893.pdf:ISMRM2018_3893.pdf:PDF},
title={Magnetic Resonance Spectroscopy biomarkers predict patient outcome in subacute spinal cord injury},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3893.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Patrik O. Wyss and Peter Zweers and Anne K. Brust and Corinne Funk and Markus F. Berger and Anke Henning},
abstract={Spinal cord injury (SCI) is a very heterogeneous disease that makes it difficult to identify a single biomarker during rehabilitation therapy in order to predict the future patient status. In this study, we applied Magnetic Resonance Spectroscopy to examine specific metabolic markers in the pons 10 weeks after injury and correlated them with changes of the clinical status obtained twice during early rehabilitation.}
}
@inproceedings{ISMRM2018_3894,
annote={ISMRM2018_3894},
pages={3894},
file={ISMRM2018_3894.pdf:ISMRM2018_3894.pdf:PDF},
title={Partial Normalization of altered brain acetate metabolism in alcohol-dependent subjects after one month of sobriety},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3894.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Lihong Jiang and Gustavo A. Angarita and Kevin L. Behar and Elizabeth Guidone and Barbara I. Gulanski and Stuart A. Weinzimer and Robin A. de Graaf and Graeme F. Mason},
abstract={The purpose of this study is to analyze the adaptation of brain acetate metabolism of AD subjects upon detoxification in order to understand the mechanism of alcohol addiction. Using 13C-magnetic resonance spectroscopy in combination of 2-13C-acetate infusion and monitor the turn over rates of brain 13C-labeled glutamate/glutamine neurotransmitter, we have found increased brain acetate metabolism after detoxification treatment, suggesting the compromised acetate uptake/metabolism in AD subjects.}
}
@inproceedings{ISMRM2018_3895,
annote={ISMRM2018_3895},
pages={3895},
file={ISMRM2018_3895.pdf:ISMRM2018_3895.pdf:PDF},
title={Investigation of ethanol stimulation on HepG2 cells in a high density cell culture on chip by correlation spectroscopy},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3895.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Dennis Kleimaier and Andreas Neubauer and Michaela Hoesl and Cordula Nies and Eric Gottwald and Lothar Schad},
abstract={Ethanol-induced toxicity leads to alterations of certain cellular functions such as mitochondrial dysfunction. This study investigated the feasibility to detect changes induced by 2‰ ethanol stimulation on HepG2 cells in an NMR-compatible bioreactor system by double quantum filtered correlation spectroscopy. During ethanol stimulation, the spectra with cells led to an increased SNR of the glucose (15.5±2.1 \%) and lactic acid (10.8\%) cross peaks. These changes were larger than the SNR reproducibility of (3.94±2.44)\%. Our results show that the DQF-COSY sequence can be used for the investigation of ethanol-induced damage on cells in a bioreactor system (worse shim condition).}
}
@inproceedings{ISMRM2018_3896,
annote={ISMRM2018_3896},
pages={3896},
file={ISMRM2018_3896.pdf:ISMRM2018_3896.pdf:PDF},
title={Response to glutaminase inhibition in patient-derived breast cancer xenograft models},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3896.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Maria Tunset Grinde and Jana Kim and Ida Marie Henriksen and Hanna Maja Tunset and Siver Andreas Moestue},
abstract={We used ex vivo 13C HR MAS MRS to determine glutamine consumption and conversion in two patient-derived xenograft models of breast cancer, aiming to identify metabolic differences between a responding (luminal-like) xenograft and a resistant (basal-like) xenograft. CB-839 inhibited tumor growth in luminal-like, but not basal-like, xenograft tumors. Response to treatment was associated with differences in glutamine utilization. Depletion of proline in responding tumors indicate that the effect of glutaminase inhibitors may be associated with metabolic adaption to tumor hypoxia.}
}
@inproceedings{ISMRM2018_3897,
annote={ISMRM2018_3897},
pages={3897},
file={ISMRM2018_3897.pdf:ISMRM2018_3897.pdf:PDF},
title={Energy Metabolism Differences in Rat Skeletal Muscle Due to Restricted Ambulation Following {SCI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3897.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Celine Baligand and Fan Ye and Sean C Forbes and Ravneet S Vohra and Jonathon Keener and Prodip Bose and Floyd Thompson and Glenn A Walter and Krista Vandenborne},
abstract={Classic rodent models of SCI can rapidly and spontaneously recover locomotor function, muscle mass and energy metabolism within weeks after injury. This is attributed to “self training” and does not replicate the conditions experienced by human patients who are often confined to bed rest for an extended period of time. Using
31P-MRS during electrically stimulated exercise to assess mitochondrial oxidative capacity in vivo, we show that restricted activity by cast immobilization delays spontaneous recovery of skeletal muscle metabolism in a rat model of severe SCI.}
}
@inproceedings{ISMRM2018_3898,
annote={ISMRM2018_3898},
pages={3898},
file={ISMRM2018_3898.pdf:ISMRM2018_3898.pdf:PDF},
title={Noninvasive biomarkers for the early diagnosis and staging of hepatic fibrosis : A real-time in vivo hyperpolarized 13C {MR} spectroscopy},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3898.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Chung-Man Moon and Yong-Yeon Jeong and Il-Woo Park and Sang-Soo Shin},
abstract={Hepatic fibrosis associated with chronic liver injury can progress to cirrhosis and ultimately hepatocellular carcinoma. To date, liver biopsy has been regarded as the gold standard for detecting hepatic fibrosis but with practical constraints. Therefore, alternative non-invasive diagnostic methods that can precisely evaluate progression of hepatic fibrosis are urgently needed. However, an in vivo study for hepatic fibrosis using hyperpolarized
13C-labeled pyruvate has not yet been attempted until now. The purpose of this study was to investigate the cellular metabolic changes at different stages of hepatic fibrosis for the early diagnosis.}
}
@inproceedings{ISMRM2018_3899,
annote={ISMRM2018_3899},
pages={3899},
file={ISMRM2018_3899.pdf:ISMRM2018_3899.pdf:PDF},
title={In vivo characterization of glucose metabolism in pancreatic cancer xenografts.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3899.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Shun Kishimoto and Jeffrey Brender and Tomohiro Seki and Ayano Enomoto and Kazutoshi Yamamoto and Murali C Krishna},
abstract={Recently, we developed a post processing denoising algorithms that are based on singular value decomposition and its multidimensional analogue Tucker decomposition. These algorithms allow more than 10-fold improvement in signal to noise ratio in dynamic spectroscopy and more than 50-fold in dynamic spectral imaging studies. Using this technique, we successfully characterize the metabolic profiles of two pancreatic ductal adenocarcinoma xenografts, MiaPaca-2 and Hs766t tumors by injecting 50 mg of 13C6 glucose. This imaging is potentially applicable to human subject and provides even more information than PET or 13C DNP MRI alone.}
}
@inproceedings{ISMRM2018_3900,
annote={ISMRM2018_3900},
pages={3900},
file={ISMRM2018_3900.pdf:ISMRM2018_3900.pdf:PDF},
title={High-Resolution Cardiopulmonary Imaging in Free-Breathing Mice using Hyperpolarized Xenon-129},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3900.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Luis Loza and Mehrdad Pourfathi and Stephen Kadlecek and Kai Ruppert and Hooman Hamedani and Sarmad Siddiqui and Faraz Amzajerdian and Yi Xin and Ryan Baron and Mary Spencer and Tahmina Achekzai and Ian Duncan and Rahim R. Rizi},
abstract={Hyperpolarized gas MRI is a well-established tool for assessing lung structure and function in both humans and large animals. However, its utility in small animal models has been limited to terminal studies, as proper gas delivery requires an MR-compatible ventilation scheme that has thus far only been achievable using a terminal intubation process. In this study, we developed a method for delivering hyperpolarized xenon-129 gas to free-breathing mice. An array of pulse sequences were used to acquire high-resolution gas- and dissolved-phase images of the heart and lung structure.}
}
@inproceedings{ISMRM2018_3901,
annote={ISMRM2018_3901},
pages={3901},
file={ISMRM2018_3901.pdf:ISMRM2018_3901.pdf:PDF},
title={Feasibility of the in vivo measurement of acetate metabolism by 1H-[13C] {MRS} at 14.1T in the mouse hypothalamus},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3901.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Blanca Lizarbe and Irene Guadilla and Rolf Gruetter},
abstract={Astrocytic metabolism is impaired in many central nervous system diseases, like obesity or diabetes. Using
1H-[
13C] MRS together with [2-
13C]acetate infusion in a 14.1T magnet, we have measured the incorporation of
13C labeling in the mouse hypothalamus in vivo and calculated its metabolic fluxes using a two-compartment metabolic model that distinguishes between neurons and astrocytes. We think that these results open the possibility of investigating local variations of astrocytic metabolism in the mouse hypothalamus in vivo.}
}
@inproceedings{ISMRM2018_3902,
annote={ISMRM2018_3902},
pages={3902},
file={ISMRM2018_3902.pdf:ISMRM2018_3902.pdf:PDF},
title={Stress Induced bioenergetic perturbations in {CMS} rat model of Depression – An invivo phosphorous{MRS} study at 7T.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3902.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Hemanth Kumar B S and Dinesh K Deelchand and Sushanta Kumar Mishra and Sadhana Singh and Subash Khushu},
abstract={A chronic mild stress (CMS) animal model for depression was developed and validated using behavioural studies like OFT, FST and SCT. Following anaesthesia, invivo Phosphorous MRS was acquired covering the entire brain using ISIS pulse sequence at field strength of 7T. The spectra thus acquired were processed using LC-model for bioenergy metabolites quantification. The overall study provides new evidence on brain energy related metabolites and redox balance in CMS rats as compared to controls, suggesting that compromised energy metabolism and altered NAD biology observed in CMS rats. The study also revealed changes in High energy phosphate metabolites and membrane phospholipids.}
}
@inproceedings{ISMRM2018_3903,
annote={ISMRM2018_3903},
pages={3903},
file={ISMRM2018_3903.pdf:ISMRM2018_3903.pdf:PDF},
title={Assessment of gene therapy efficacy by neurochemical profiling},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3903.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ivan Tkac and Igor Nastrasil and Kanut Laoharawee and Kelly M Podetz-Pedersen and Kelley F Kitto and Carolyn A Fairbanks and Walter C Low and Karen Kozarsky and R Scott McIvor},
abstract={Mucopolysaccharidosis type II (MPS II), also known as Hunter syndrome, is a rare X-linked recessive lysosomal disorder caused by defective iduronate-2-sulfatase (IDS). Enzyme replacement is the only FDA–approved therapy available for MPS II, but it does not improve neurologic outcomes in MPS II patients. The 1H MRS data acquired from the hippocampus and cerebellum of untreated and AAV9-IDS treated MPS II mice and heterozygote controls clearly demonstrate that the direct transfer of the missing IDS gene to the CNS at 12 weeks of age prevented neurochemical alternations typical for MPS II at 9 months of age.}
}
@inproceedings{ISMRM2018_3904,
annote={ISMRM2018_3904},
pages={3904},
file={ISMRM2018_3904.pdf:ISMRM2018_3904.pdf:PDF},
title={Relationship of longitudinal changes in cerebral metabolite and diffusivity property during the early brain development},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3904.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Chun-Xia Li and Yuguang Meng and Hui Mao and Anthony WS Chan and Xiaodong Zhang},
abstract={In vivo Magnetic Resonance Spectroscopy (MRS) is widely used to characterize the cerebral metabolic disorders in the developing brains of human and animal models. Prior study has demonstrated the spatial and temporal difference in evolution pattern of each metabolite during early brain maturation. This study is aimed to investigate the relationship of the longitudinal change of each metabolite with the microstructural evolution during early brain development in the cingulate cortex (ACC) of rhesus monkeys. The results demonstrated the heterogeneity of correlation degree of each metabolite with the microstructural maturation, suggesting combined MRS/DTI examination could offer complementary information to characterize early brain maturation and related disorders in pediatric research.}
}
@inproceedings{ISMRM2018_3905,
annote={ISMRM2018_3905},
pages={3905},
file={ISMRM2018_3905.pdf:ISMRM2018_3905.pdf:PDF},
title={Higher Vitamin C Concentration in Patients with Alzheimer’s Disease},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3905.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Malgorzata Marjanska and J Riley McCarten and Laura Hemmy and Melissa Terpstra},
abstract={The concentrations of the antioxidants vitamin C (ascorbate, Asc) and glutathione (GSH) were quantified as components of the neurochemical profile using 7 T 1H MRS in patients with Alzheimer’s disease (AD) and age-matched controls. Spectra were measured at ultra-short echo time in the posterior cingulate cortex (PCC), which is involved in AD and the occipital cortex (OCC) as a control region. In patients, the concentrations of Asc and myo-inositol were higher in both regions. In the PCC of patients, total choline concentration was also higher.}
}
@inproceedings{ISMRM2018_3906,
annote={ISMRM2018_3906},
pages={3906},
file={ISMRM2018_3906.pdf:ISMRM2018_3906.pdf:PDF},
title={Differences in steady-state glutamate levels and variability between ‘non-task-active’ control conditions: Evidence from ¹H f{MRS} of the prefrontal cortex},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3906.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jonathan D Lynn and Eric A Woodcock and Chaitali Anand and Dalal Khatib and Jeffrey A Stanley},
abstract={Proton functional magnetic resonance spectroscopy (1H fMRS) is capable of detecting dynamic changes in brain glutamate related to task engagement compared to a “non-task-active” control condition. The selection of an appropriate control condition is critical, which may confound the magnitude change in glutamate modulation. The purpose of this 1H fMRS study was to compare the steady-state levels of glutamate and its variability in the left dorsolateral prefrontal cortex during four different putative control conditions. Results show significant differences in the glutamate level and variability between conditions, emphasizing the importance of the control condition for the detection of task-evoked glutamate modulation.}
}
@inproceedings{ISMRM2018_3907,
annote={ISMRM2018_3907},
pages={3907},
file={ISMRM2018_3907.pdf:ISMRM2018_3907.pdf:PDF},
title={Metabolic basis of (de)activation f{MRI} paradigms: J-edited lactate and diffusion-weighted water 1H-{MRS}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3907.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yury Koush and Robin A. de Graaf and Ron Kupers and Laurence Dricot and Douglas L. Rothman and Fahmeed Hyder},
abstract={During task-based versus rest epochs, the BOLD signal increases in a task-positive region (activation paradigm) and decreases in a task-negative region (deactivation paradigm), also known as the default mode network (DMN). We investigated the metabolic basis of (de)activation paradigms using concurrent
1H-MRS acquisitions of J-edited lactate and diffusion-weighted water. Using (de)activation paradigms, we detected associated increase of water (i.e., BOLD signal) and lactate in visual cortex (non-DMN area), whereas in posterior cingulate cortex (DMN area) water decreased but lactate did not change. These results suggest similar degrees of aerobic glycolysis in both DMN and non-DMN areas.}
}
@inproceedings{ISMRM2018_3908,
annote={ISMRM2018_3908},
pages={3908},
file={ISMRM2018_3908.pdf:ISMRM2018_3908.pdf:PDF},
title={Neurochemical profiling in the rat model of Tourette’s Syndrome @ 11.7T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3908.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Alireza Abaei and Francesca Rizzo and Dinesh K Deelchand and Tobias M. Böckers and Volker Rasche},
abstract={Tourette’s syndrome (TS) is a neurodevelopmental disorder characterized primarily by motor tics probably due to dysfunctions of the cortico-striato-thalamic-cortical loop (CSTC) but the underlying molecular reason why tic occur is not yet known. In this study, a dedicated optimized STEAM sequence with single-shot phase and frequency correction and image-based shimming was applied to uncover the metabolic “signature” of a tic using in vivo
1H-MRS at 11.7T. Despite a clear ticking phenotype observed in our animal model, the unaltered striatal neurochemical profile suggest questions on the role of the striatum within the supposed dysfunctional cortical-striatal-thalamic-cortico circuitry in TS.}
}
@inproceedings{ISMRM2018_3909,
annote={ISMRM2018_3909},
pages={3909},
file={ISMRM2018_3909.pdf:ISMRM2018_3909.pdf:PDF},
title={Correlations Between Brain Structural Volumes and Brain Metabolite Concentrations in Alzheimer’s Disease: Preliminary Results from the NeuroMet Project},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3909.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ariane Fillmer and Theresa Köbe and Semiha Aydin and Laura Goeschel and Agnes Flöel and Florian Schubert and Bernd Ittermann},
abstract={The NeuroMet project aims to identify new biomarkers for Alzheimer’s disease (AD) and to reduce measurement uncertainties for known biomarkers for AD. This work presents first NeuroMet results with a focus on ultra-high field MR imaging and MR spectroscopy. Significant correlations were found between volumes of cortical and subcortical gray matter structures and concentrations of NAA, glutamate and GABA.}
}
@inproceedings{ISMRM2018_3910,
annote={ISMRM2018_3910},
pages={3910},
file={ISMRM2018_3910.pdf:ISMRM2018_3910.pdf:PDF},
title={Brain lithium and myo-inositol levels in lithium treated and non-lithium treated bipolar disorder patients},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3910.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Fiona Elizabeth Smith and Peter Edward Thelwall and Carly Jay Flowers and Matthew George Birkbeck and Joe Necus and Andrew Matthew Blamire and David Andrew Cousins},
abstract={The action of lithium in bipolar disorder (BD) is incompletely defined but the inositol depletion hypothesis
1 states that lithium inhibits IMPase to deplete myo-inositol, confirmed in vivo using proton magnetic resonance spectroscopy (
1H-MRS) following acute treatment
2,3 Chronic treatment may upregulate IMPase, with trend-level increases in grey matter myo-inositol reported.
4 This
1H-MRS study compares frontal white matter myo-inositol/creatine levels (8cm
3voxel)in BD subjects (lithium-treated versus BD controls taking other medication), supplemented by measuring brain lithium signal intensity using 3D
7Li-MRI.Myo-Ino/Crlevels were significantly lower in the lithium-treated group, but their levels did not correlate with
7Li-MRI signal intensity.}
}
@inproceedings{ISMRM2018_3911,
annote={ISMRM2018_3911},
pages={3911},
file={ISMRM2018_3911.pdf:ISMRM2018_3911.pdf:PDF},
title={{MR}-Spectroscopic Imaging in the Spotlight of the 2016 {WHO} Classification},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3911.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Elie Diamandis and Carl Philipp Simon Gabriel and Horst Urbach and Irina Mader and Dieter Henrik Heiland},
abstract={The purpose of this study is to map spatial metabolite differences across the three molecular subgroups of glial tumors, defined by the IDH1/2 mutation and 1p19q-co-deletion, using chemical shift imaging. The classification was based on a radiomic approach to the spectroscopic data.
}
}
@inproceedings{ISMRM2018_3912,
annote={ISMRM2018_3912},
pages={3912},
file={ISMRM2018_3912.pdf:ISMRM2018_3912.pdf:PDF},
title={Synthetic {MRI} of bone metastases in castration-resistant prostate cancer: detection of tumor activity and calcifications.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3912.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yuki Arita and Taro Takahara and Soichiro Yoshida and Thomas C Kwee and Tatsuaki Kobayashi and Chikako Ishii and Jun Kurasawa and Kazuya Sugimoto and Nobuya Higuchi and Yasuhisa Fujii},
abstract={We quantified T1, T2 and proton density (PD) of bone metastases in castration-resistant prostate cancer with synthetic MRI (SyMRI). Bone foci of interest were classified into four groups; active disease, red bone marrow (RBM), inactive disease without calcification (Inactive C(-)) and inactive disease with calcification (Inactive C(+)). Active disease group showed very high PD and Inactive C(+) group showed very low PD. Both Inactive C(-) and RBM showed medium values. Significant differences were noted among these three divisions. SyMRI thus shows clinical potential to differentiate active/inactive lesions, calcifications and red bone marrow in castration-resistant prostate cancer.}
}
@inproceedings{ISMRM2018_3913,
annote={ISMRM2018_3913},
pages={3913},
file={ISMRM2018_3913.pdf:ISMRM2018_3913.pdf:PDF},
title={Hyperpolarized [1-
13C]Pyruvate Imaging Predicts Survival in Rat C6 Glioma Model},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3913.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Keshav Datta and Mette H. Lauritzen and Milton Merchant and Taichang Jang and Shie-Chau Liu and Ronald D. Watkins and Ralph E. Hurd and Lawrence Recht and Daniel M. Spielman},
abstract={The [1-
13C]Lactate/[1-
13C]Bicarbonate ratio at 48 hrs post-treatment, as measured in a hyperpolarized [1-
13C]Pyruvate experiment, was found to accurately predict the survival in rat C6 glioma model treated with a single dose of the anti-VEGF drug Bevacizumab.}
}
@inproceedings{ISMRM2018_3914,
annote={ISMRM2018_3914},
pages={3914},
file={ISMRM2018_3914.pdf:ISMRM2018_3914.pdf:PDF},
title={Radiomics: a novel {MRI}-based method of predicting recurrence in chordoma},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3914.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Wei Wei and Ke Wang and Kaibing Tian and Zhenyu Liu and Liang Wang and Junting Zhang and Zhen Wu and Jie Tian},
abstract={In order to find the relationship between MRI image and the postoperative recurrence of chordoma, we used a novel radiomics method for quantitative analysis of MRI image. Finally successfully predicted the probability of postoperative recurrence of chordoma.}
}
@inproceedings{ISMRM2018_3915,
annote={ISMRM2018_3915},
pages={3915},
file={ISMRM2018_3915.pdf:ISMRM2018_3915.pdf:PDF},
title={Low nodal plasma volume is associated with poor treatment response in head and neck cancer treated with induction chemotherapy.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3915.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Rafal Panek and Kee H. Wong and Liam Welsh and Alex Dunlop and Dualta Mcquaid and Angela M. Riddell and Dow-Mu Koh and Martin O. Leach and Shreerang A. Bhide and Kevin J. Harrington and Christopher M. Nutting and Kate L. Newbold and Maria Schmidt},
abstract={Impaired tumour perfusion results in decreased efficacy of cancer treatment. In this work we investigated the optimal timing and predictive value of early chemotherapy induced changes, measured by dynamic contrast enhanced (DCE) and longitudinal intrinsic susceptibility (IS) MRI. We observed lower plasma volume in metastatic nodes responding poorly to the treatment. We found that for HNSCC patients treated with induction chemotherapy, combining DCE and IS-MRI methods improves early predictive value. This methodology could be used to aid patient stratification and subsequent radiotherapy treatment planning.}
}
@inproceedings{ISMRM2018_3916,
annote={ISMRM2018_3916},
pages={3916},
file={ISMRM2018_3916.pdf:ISMRM2018_3916.pdf:PDF},
title={Oxygen-Enhanced {MRI} for the Detection of Hypoxia in Patients with Head and Neck Cancer},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3916.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Rafal Panek and Kee H. Wong and Liam Welsh and Angela M. Riddell and Dow-Mu Koh and Veronica Morgan and Shreerang A. Bhide and Kevin J. Harrington and Christopher M. Nutting and Maria Schmidt and Martin O. Leach and James P.B. O’Connor and Kate L. Newbold and Simon P. Robinson},
abstract={Tumour hypoxia is a recognized cause of treatment failure. Noninvasive methods to quantify distribution and extent of hypoxia remain an unmet clinical need. Quantitation of the longitudinal relaxation rate, R
1, using oxygen-enhanced MRI (OE-MRI), can be used to monitor differences in levels of paramagnetic molecular oxygen in plasma. In this study, we report a significantly reduced hyperoxia-induced ΔR
1 response in HNSCC in comparison to the healthy lymph nodes, revealed by OE-MRI. Such a reduction can be attributed to regions of impaired tumour vasculature and hypoxia, the presence of which may be linked to a poorer outcome.}
}
@inproceedings{ISMRM2018_3917,
annote={ISMRM2018_3917},
pages={3917},
file={ISMRM2018_3917.pdf:ISMRM2018_3917.pdf:PDF},
title={Correlation of {CD}31-Based Microvessel Density and Percent Area Measurements against 13C-tert-butanol {MRI} Perfusion Mapping in a Sunitinib-Resistant {RCC} Xenograft},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3917.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Patricia Coutinho de Souza and Aaron Grant and Xiaoen Wang and Rupal Bhatt and Gopal Varma and David Alsop and Leo Tsai},
abstract={Tumor heterogeneity is deeply associated with regional perfusion. Improved evaluation of local perfusion, by imaging or histology, can be useful for tracking tumor progression and treatment. Here we use h13C-tert-butanol, a high-SNR quantitative MRI perfusion marker, to map perfusion in untreated (UT) and sunitinib-resistant (SR) renal cell carcinoma (RCC) xenografts. This study investigates the correlation between these perfusion maps with histologic measures of vascularity using CD31-labeled sections.}
}
@inproceedings{ISMRM2018_3918,
annote={ISMRM2018_3918},
pages={3918},
file={ISMRM2018_3918.pdf:ISMRM2018_3918.pdf:PDF},
title={Hydrogen magnetic resonance spectroscopy: a technique for predicting clinical outcome in patients with head \& neck squamous cell cancer with locally advanced cervical nodal disease},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3918.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Sola Adeleke and Marianthi-Vasiliki Papoutsaki and Harbir Sidhu and Alan Bainbridge and David Price and Dawn Carnell and Martin Forster and Ruheena Mendes and Shonit Punwani},
abstract={Hydrogen magnetic resonance spectroscopy (1H-MRS) is a technically challenging modality. It has the potential to provide specific metabolic information that could guide clinical decision making. In this study we assess feasibility of performing 1H MRS in patients with head and neck squamous cell carcinoma (HNSCC) prior to treatment and explore its correlation with post-treatment outcomes.}
}
@inproceedings{ISMRM2018_3919,
annote={ISMRM2018_3919},
pages={3919},
file={ISMRM2018_3919.pdf:ISMRM2018_3919.pdf:PDF},
title={Noninvasive prediction of tumor-fibrosis using texture analysis of multiparametric {MRI} in pancreatic cancer model},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3919.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Dae Chul Jung and Ravneet Vohra and Seon Young Lee and Kyunghwa Han and Helen Hong and Donghoon Lee},
abstract={Authors want to evaluate the correlations between texture features of tumor on multi-parametric MRI (mp-MRI) and tumor-fibrosis in animal model of pancreatic cancer. mp-MRI was performed in a genetically engineered mice model of human pancreatic cancer. Texture features of tumors were extracted from each parametric map using texture analysis. Linear regression with LASSO method was used to evaluate the correlations between the texture features and percentage of fibrosis on histologic slides. Several texture features were correlated with tumor fibrosis. Statistical learning showed preliminary prediction model. Texture analysis of mp-MRI is helpful for predicting and monitoring tumor-fibrosis in pancreatic cancer model.}
}
@inproceedings{ISMRM2018_3920,
annote={ISMRM2018_3920},
pages={3920},
file={ISMRM2018_3920.pdf:ISMRM2018_3920.pdf:PDF},
title={Prediction of pathological complete response of rectal tumor by radiomics method based on diffusion kurtosis imaging results before neoadjuvant chemoradiotherapy},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3920.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Xiaoyan Zhang and Haitao Zhu and Xiaoting Li and Yanjie Shi and Yingshi Sun and Aijun Zhang and Haoyu Li},
abstract={Neoadjuvant chemoradiotherapy is the standard treatment for locally advanced rectal cancer. Patients with pathological complete response (pCR) after NCRT (15~21\% of the total) could benefit from either less invasive surgery or a “wait-and-see” strategy. A radiomics model is proposed in this work based on diffusion kurtosis imaging (DKI) result before NCRT is used to predict pCR of rectal cancer.}
}
@inproceedings{ISMRM2018_3921,
annote={ISMRM2018_3921},
pages={3921},
file={ISMRM2018_3921.pdf:ISMRM2018_3921.pdf:PDF},
title={Development of a Patient-specific Tumor Mold using {MRI} and 3D Printing Technology for Targeted Tissue Procurement and Radiomics Analysis of Renal Masses},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3921.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Durgesh Kumar Dwivedi and Yonatan Chatzinoff and Qing Yuan and Jeffrey A. Cadeddu and Payal Kapur and Ivan Pedrosa},
abstract={To implement a platform for co-localization of in vivo quantitative multi-parametric magnetic resonance imaging (mpMRI) features with ex vivo surgical specimens of patients with renal masses using patient-specific 3D-printed tumor molds, which may aid in targeted tissue procurement and radiomics/radiogenomicanalyses. Volumetric segmentation of 6 renal masses was performed with 3D Slicer (http://www.slicer.org) to create a three-dimensional (3D) tumor model. All patients successfully underwent partial nephrectomy and adequate fitting of the tumor specimens within the 3D mold was achieved in all tumors. Distinct in vivo MRI features corresponded to unique pathologic characteristics in the same tumor.}
}
@inproceedings{ISMRM2018_3922,
annote={ISMRM2018_3922},
pages={3922},
file={ISMRM2018_3922.pdf:ISMRM2018_3922.pdf:PDF},
title={Rectal cancer: multi-parametric {MRI} 3-dimensional assessment of intra-tumour heterogeneity and chemoradiotherapy response prediction},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3922.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Trang Thanh Pham and Gary Liney and Karen Wong and Christopher Henderson and Robba Rai and Petra L Graham and Malcolm Hudson and Nira Borok and Minh Xuan Truong and Mark Lee and Joo-Shik Shin and Michael B. Barton},
abstract={This study investigated 3D quantitative histogram assessment of diffusion weighted imaging (DWI) and dynamic contrast enhanced (DCE) MRI in the prediction of chemoradiotherapy (CRT) response in locally advanced rectal cancer. Histopathologic response assessment was centralised and defined according to AJCC tumour regression grade. A whole tumour histogram analysis and combined multiparametric scatterplots of ADC and Ktrans were used to assess tumour heterogeneity and prediction of CRT response. Post-CRT ADC 75th and 90th histogram quantiles were the most promising parameters for prediction of CRT response. However, DCE-MRI and multi-parametric scatterplots combining ADC and Ktrans did not add value in predicting response.}
}
@inproceedings{ISMRM2018_3923,
annote={ISMRM2018_3923},
pages={3923},
file={ISMRM2018_3923.pdf:ISMRM2018_3923.pdf:PDF},
title={Early Prediction of Soft Tissue Sarcoma Response to Preoperative Therapy Using {DCE}-{MRI} Texture Features},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3923.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Tristan Xiao and Archana Machireddy and Xubo Song and Alina Tudorica and Aneela Afzal and May Mishal and Brooke Beckett and Megan Holtorf and Torrie Aston and Christopher Ryan and Wei Huang and Guillaume Thibault},
abstract={23 patients with soft tissue sarcoma (STS) (25 tumors) underwent DCE-MRI before and after one cycle of preoperative chemoradiotherapy. Extended Tofts model (ETM) and Shutter-Speed model (SSM) were used for pharmacokinetic (PK) analysis of DCE-MRI data and generating voxel based PK parametric maps, from which texture features were extracted using different statistical matrix methods. Changes in SZM and RLM features consistently provided good early prediction of therapy response, while more features from the SSM PK maps were good predictors of response than the ETM maps.}
}
@inproceedings{ISMRM2018_3924,
annote={ISMRM2018_3924},
pages={3924},
file={ISMRM2018_3924.pdf:ISMRM2018_3924.pdf:PDF},
title={{MRS} measurement of succinate in vivo as a biomarker in succinate dehydrogenase deficient tumours},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3924.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Mary A McLean and Ruth T Casey and Benjamin G Challis and Rogier ten Hoopen and Thomas Roberts and Graeme R Clark and Deborah Pittfield and Helen L Simpson and Venkata R Bulusu and Kieran Allinson and Lisa Happerfield and Soo-Mi Park and Alison Marker and Olivier Giger and Basetti Madhu and Eamonn R Maher and Ferdia A Gallagher},
abstract={We performed respiratory-gated single-voxel
1H-MRS (TE = 144ms; voxel size 2.2-100ml; 96-512 averages) at 3T in tumours with suspected mutations in the mitochondrial enzyme succinate dehydrogenase (SDH) in 15 patients, analysed using LCModel. A germline mutation or epimutation in one of the SDH genes was identified in 11/15 subjects, with concordant MRS findings in 9 subjects, data rejection as technical failure in 4 and equivocal results in 2. Referencing succinate peaks to choline was an important quality control for discrimination of true from false negatives. MRS may provide a useful biomarker of SDH activity in this patient group.}
}
@inproceedings{ISMRM2018_3925,
annote={ISMRM2018_3925},
pages={3925},
file={ISMRM2018_3925.pdf:ISMRM2018_3925.pdf:PDF},
title={Assessment of Tumor Microenvironment to Determine the Most Suitable Therapeutic Window in an Ovarian Cancer Model},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3925.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Sarah Belderbos and Kristof Govaerts and Anca Croitor Sava and Jens Wouters and Bella B. Manshian and Christophe M. Deroose and Sabine Van Huffel and Stefaan J. Soenen and Willy Gsell and Uwe Himmelreich},
abstract={Multimodal imaging, i.e. combining (simultaneous) positron emission tomography (PET)-magnetic resonance imaging (MRI) and bioluminescence imaging (BLI) allows in-depth assessment of changes in tumor microenvironment over time. In this study, the development of human ovarian xenografts in mice was longitudinally monitored using BLI and PET-MRI to identify the most suitable time window to test nanomaterial-based therapies. Under these conditions, xenografts are viable, vascularized and metabolically active tumor masses with leaky blood vessels after four weeks, indicating a suitable time point for nanomaterial administration. This suggests that a combination of PET, MRI and BLI allows the identification of potential therapeutic windows.}
}
@inproceedings{ISMRM2018_3926,
annote={ISMRM2018_3926},
pages={3926},
file={ISMRM2018_3926.pdf:ISMRM2018_3926.pdf:PDF},
title={Spatial comparison of in vivo {MRI} with digital histology validates R
2* as a biomarker of vascular hemodynamics in the Th-{MYCN} model of neuroblastoma},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3926.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Konstantinos Zormpas-Petridis and Matthew D. Blackledge and Louis Chesler and Yinyin Yuan and Simon P. Robinson and Yann Jamin},
abstract={This study explores the use of automated image analysis pipelines and kernel density estimation (KDE) analysis for hotspot mapping as a generic methodology to spatially evaluate MRI biomarkers with corresponding high-resolution whole-slide digital histology, used here to validate the transverse relaxation R
2* as a biomarker of vascular hemodynamics in the Th-MYCN transgenic mouse model of childhood neuroblastoma.}
}
@inproceedings{ISMRM2018_3927,
annote={ISMRM2018_3927},
pages={3927},
file={ISMRM2018_3927.pdf:ISMRM2018_3927.pdf:PDF},
title={Imaging immunotherapy resistance in melanoma in vivo and in vitro employing magnetic resonance},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3927.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Shivanand Pudakalakatti and Ashvin Jaiswal and Prasanta Dutta and Michael Curran and Pratip Bhattacharya},
abstract={Identifying immunotherapy resistance and underlying molecular mechanisms of resistance will help in stratifying immunotherapy treatment effectively. However, identifying immunotherapy resistance and its causative mechanisms are elusive. Here we have developed mouse models of immunotherapy resistance and identified molecular mechanisms indicating immunotherapy resistance employing magnetic resonance. In vitro studies showed adaptations in metabolic pathways of glycolysis, fatty acid and purine synthesis in resistant cell lines. In vivo experiments with 1-
13C hyperpolarized pyruvate revealed higher pyruvate to lactate conversion in immunotherapy resistant mice compared to responding ones. Hence, pyruvate to lactate ratio can be a potential biomarker to identify immunotherapy resistance in vivo.}
}
@inproceedings{ISMRM2018_3928,
annote={ISMRM2018_3928},
pages={3928},
file={ISMRM2018_3928.pdf:ISMRM2018_3928.pdf:PDF},
title={Multi-Resolution Fractal Analysis of {DCE}-{MRI} Parametric Maps for Early Prediction of Breast Cancer Therapy Response},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3928.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Archana Machireddy and Guillaume Thibault and Alina Tudorica and Aneela Afzal and May Mishal and Kathleen Kemmer and Arpana Naik and Megan Troxell and Eric Goranson and Karen Oh and Nicole Roy and Neda Jafarian and Megan Holtorf and Wei Huang and Xubo Song},
abstract={DCE-MRI data from 54 breast cancer patients collected before and after one cycle of neoadjuvant chemotherapy were subjected to Shutter-Speed pharmacokinetic analysis. A new texture feature, multi-resolution fractal dimension (FD), was extracted from DCE-MRI parametric maps and compared with single-resolution FD for early prediction of therapy response. The multi-resolution approach appears to provide a richer description of the underlying tumor heterogeneity in perfusion/permeability than the single-resolution FD method and has higher accuracy in early discrimination of pathologic complete response (pCR) from non-pCR.}
}
@inproceedings{ISMRM2018_3929,
annote={ISMRM2018_3929},
pages={3929},
file={ISMRM2018_3929.pdf:ISMRM2018_3929.pdf:PDF},
title={{PERFUSION} {MRI} {AS} A {MARKER} {OF} {GLIOBLASTOMA} {INFILTRATION} {INTO} {HEALTHY} {TISSUE}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3929.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Antoine Vallatos and Haitham F. I. Al-Mubarak and Joanna L. Birch and Lindsay Gallagher and James Mullin and Lesley Gilmour and William M. Holmes and Anthony J. Chalmers},
abstract={We investigate the ability of perfusion MRI to probe glioblastoma infiltration into healthy brain tissue, on a patient-derived mouse model presenting infiltrative tumour margins. Using a high SNR Arterial Spin Labelling sequence and a multiple slice in-plane histology method, we show that perfusion imaging can probe lower tumour cell density regions than conventional MRI. Voxel-to-voxel comparison between perfusion and tumour cell density images, allows identifying a negative relation between tumour cell burden and perfusion at the invasion margins. This relation, related to vascular co-option mechanisms, could be used as a marker of tumour cell infiltration into healthy tissue.}
}
@inproceedings{ISMRM2018_3930,
annote={ISMRM2018_3930},
pages={3930},
file={ISMRM2018_3930.pdf:ISMRM2018_3930.pdf:PDF},
title={Diffusion-Weighted {MRI} Apparent Diffusion Coefficient ({ADC}) Histogram Changes In Primary Rectal Cancer Treated With Chemotherapy + Anti-Angiogenic Therapy Versus Neoadjuvant Chemoradiation},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3930.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={N. Jane Taylor and Davide Prezzi and J. James Stirling and James A d'Arcy and Rob Glynne-Jones and Vicky J Goh},
abstract={Changes in the apparent diffusion co-efficient (ADC) histogram parameters in primary rectal cancers treated with neoadjuvant chemotherapy + anti-angiogenic therapy (NAC) differ substantially to those treated with chemoradiation (CRT), reflecting the differing mechanisms of action of these therapies. Higher diffusivity and lower variance post-CRT compared to NAC in responders likely reflects radiotherapy-related inflammation.}
}
@inproceedings{ISMRM2018_3931,
annote={ISMRM2018_3931},
pages={3931},
file={ISMRM2018_3931.pdf:ISMRM2018_3931.pdf:PDF},
title={Multi-parametric imaging based differentiation of primary {CNS} lymphoma from Glioblastoma using T1-Perfusion, Diffusion and Susceptibility-weighted {MR} Imaging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3931.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Pradeep Kumar Gupta and Jitender Saini and Ashish Awasthi and Chandra M Pandey and Shreelekha Mohapatra and Anup Singh and Rana Patir and Sunita Ahlawat and Manish Beniwal and Anita Mahadevan and Rakesh Kumar Gupta},
abstract={Glioblastoma and primary CNS lymphoma (PCNSL) need differentiation on pre operative imaging as management strategies for these two pathologies are diverse. Due to the presence of atypical imaging findings in a significant number of cases, it becomes difficult to differentiate these two pathologies on conventional MRI. We utilized multi-parametric imaging methods (T1-perfusion, DWI and SWI) for possible differentiation of these two entities. In linear discriminant analysis using various imaging parameters we achieved 84\% accuracy with AUC 90.14\%. We conclude that multi-parametric imaging may prove to be useful in accurate preoperative discrimination of these two pathologies.}
}
@inproceedings{ISMRM2018_3932,
annote={ISMRM2018_3932},
pages={3932},
file={ISMRM2018_3932.pdf:ISMRM2018_3932.pdf:PDF},
title={Towards quantitative multiparametric evaluation of response to treatment following loco-regional treatment for {HCC}- pilot study.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3932.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Sonal Krishan and Amit Mehndiratta},
abstract={The aim of the present study was to explore the feasibility and utility of quantitative volumetric change in ADC, tumor volume and percentage differential enhancement in the various phases in being able to predict response to treatment following loco-regional therapy (LRT).This IRB approved pilot study included 40 consecutive patients following LRT for HCC .Patients with baseline imaging, 1,3 and 6 months follow up dynamic contrast-enhanced MRI were included in our study. Percentage change in arterial, portal venous and hepatic-venous differential enhancement, as well as changein ADC and tumor volume at 1 and 3 months, was calculated for all values. There was globalreduction in the percentage of mean volume anddifferential enhancementis seen in all phases in completelytreated study group.In patients with residual tumor, there is paradoxicaldecrease in ADC and increase in hepatic venous enhancement at 1 month.Our pilot study has shown that volumetric quantitative evaluation of differential enhancement of the treated lesion in various phases combined with ADC and change in tumourvolume are feasible. This has potential to act as surrogate markers for evaluating response to treatment}
}
@inproceedings{ISMRM2018_3933,
annote={ISMRM2018_3933},
pages={3933},
file={ISMRM2018_3933.pdf:ISMRM2018_3933.pdf:PDF},
title={Functional diffusion maps to assess treatment response in head and neck tumors using {SPLICE}.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3933.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Boris Peltenburg and Tim Schakel and Chris H.J. Terhaard and Remco de Bree and Marielle E.P. Philippens},
abstract={ADC changes during chmoradiation treatment might be of prognostic value in patients with head and neck squamous cell carcinoma (HNSCC) and allow for treatment modification. To overcome decrease in tumor visibility and increase in delineation variation by observers, functional diffusion maps provide an objective measure to follow response on DW-MRI during treatment provided a good geometric accuracy as is offered by the SPLICE technique.}
}
@inproceedings{ISMRM2018_3934,
annote={ISMRM2018_3934},
pages={3934},
file={ISMRM2018_3934.pdf:ISMRM2018_3934.pdf:PDF},
title={Multiparametric {MRI} as a biomarker of response to neoadjuvant second-generation hormone therapy for localized prostate cancer- a pilot study},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3934.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Fiona Fennessy and Andriy Fedorov and Mark Vangel and Robert Mulkern and Rosina Lis and Maria Tretiakova and Clare Tempany and Mary Ellen Taplin},
abstract={Advanced prostate cancer (PCa) is driven by androgen receptor (AR) signaling and as such the AR is an important therapeutic target to prevent PCa progression. The aim of this pilot study was to explore a role for prostate multiparametric MRI (mpMRI) as a biomarker for treatment response of localized prostate cancer to neoadjuvant treatment with the second-generation AR inhibitor enzalutamide. We demonstrate that quantitative mpMRI may play an important role as a biomarker of response to neoadjuvant treatment of localized PCa and MRI-based tumor volumetrics may act as a surrogate for RCB at prostatectomy. These findings are worthy of investigation in a larger clinical setting.}
}
@inproceedings{ISMRM2018_3935,
annote={ISMRM2018_3935},
pages={3935},
file={ISMRM2018_3935.pdf:ISMRM2018_3935.pdf:PDF},
title={{MEMRI}-guided preclinical trial of an experimental {TAM}-targeted therapy in mouse medulloblastoma},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3935.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Hari Rallapalli and I-Li Tan and Alexandre Wojcinski and Alexandra L Joyner and Daniel H Turnbull},
abstract={Using our high-throughput MEMRI pipeline, presented previously, we tested an experimental anticancer drug in mouse models of sporadic medulloblastoma.
}
}
@inproceedings{ISMRM2018_3936,
annote={ISMRM2018_3936},
pages={3936},
file={ISMRM2018_3936.pdf:ISMRM2018_3936.pdf:PDF},
title={Evaluation of Pharmacokinetic Models for Perfusion Imaging with Dynamic Contrast-Enhanced Magnetic Resonance Imaging in Skeletal Muscle Using Low-Molecular-Weight Contrast Agents},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3936.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Stefan Hindel and Giorgos Papanastasiou and Peter Wust and Marc Maaß and Anika Söhner and Lutz Lüdemann},
abstract={Pharmacokinetic models for perfusion quantification with DCE-MRI using a low-molecular-weight contrast agent (LMCA) in skeletal muscle of pigs were validated. This in vivo study included compartmental and distributed parameter models which allow estimation of the functional and structural composition of heterogeneously perfused tissues. The different tracer kinetic models, which measure transport parameters in physically meaningful units in heterogeneous tissue, were compared to identify a method that allows reliable quantitative determination of physiological parameters. Double-contrast agent DCE-MRI using LMCA and intravascular CA in combination with the 2-compartment exchange model extended by a nonnutritive arteriolar compartment yields the most reliable results.}
}
@inproceedings{ISMRM2018_3937,
annote={ISMRM2018_3937},
pages={3937},
file={ISMRM2018_3937.pdf:ISMRM2018_3937.pdf:PDF},
title={Locally constrained registration of dynamic contrast enhanced {MRI} time series improves tracer kinetic model voxel-wise fit repeatability in liver tumours},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3937.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Michael Berks and Ross A Little and Yvonne Watson and Sue Cheung and Gordon C Jayson and James P B O'Connor and Geoff J M Parker},
abstract={DCE-MRI enables the estimation of clinically useful parameters of tissue microvasculature and is frequently used in trials of anti-angiogenic drugs. However tissue movement can lead to inaccurate parameter estimation. Rapidly changing contrast and limited spatial structure within tumours makes DCE-registration a challenging task. We present a novel algorithm that estimates a model of local tumour motion from the most stable part of the time-series and uses this to constrain registration of the whole series. We demonstrate statistically significant improved extended Kety-model fits and improved parameter repeatability for a set of 59 liver tumours in 40 patients, at two baseline scans.}
}
@inproceedings{ISMRM2018_3938,
annote={ISMRM2018_3938},
pages={3938},
file={ISMRM2018_3938.pdf:ISMRM2018_3938.pdf:PDF},
title={Monitoring theragnostic drug delivery in tumors using Fe({III}) metal crosslinked-micelles at 7T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3938.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={William Dominguez-Viqueira and Tara L Costich and Epifanio Ruiz and Kevin N Sill and Suzanne J Bakewell and Gary Martinez},
abstract={Stabilized micelles have shown prolonged blood circulation and targeting to solid tumors through enhanced permeability and retention (EPR) effect. It has been demonstrated that Intezyne's Versatile Encapsulation and Crosslinking Technology (IVECT™) has the advantage of allowing the micelles to be crosslinked via a pH-sensitive Fe(III) metal coordination reaction that permeates xenografted tumors and clears from circulation without retention in the kidneys or liver. In this work we developed a theragnostic method to study drug delivery over time of IVECT by T1-weighted image histogram and image intensity in the tumor, kidneys, liver and muscle in a HCT116 Xenograft Model.}
}
@inproceedings{ISMRM2018_3939,
annote={ISMRM2018_3939},
pages={3939},
file={ISMRM2018_3939.pdf:ISMRM2018_3939.pdf:PDF},
title={In Search of Repeatable and Useful Prostate {DCE}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3939.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Sharon Peled and Michael Schwier and Mark Vangel and Clare Tempany and Ron Kikinis and Andrey Fedorov and Fiona Fennessy},
abstract={This work aims to improve the practical utility of DCE derived quantitative biomarkers by comparing the repeatability of DCE calculated parameters across analysis methods and across AIF choices. The data consists of two scans each from a set of 15 patients with suspected prostate cancer, repeated within 14 days without intervening therapy.}
}
@inproceedings{ISMRM2018_3940,
annote={ISMRM2018_3940},
pages={3940},
file={ISMRM2018_3940.pdf:ISMRM2018_3940.pdf:PDF},
title={Tumorigenesis in glioblastoma multiforme: Longitudinal mapping of glioma growth and extracellular pH},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3940.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={John J Walsh and Lucas C Adam and Maxime J Parent and Daniel Coman and Samuel K Maritim and Fahmeed Hyder},
abstract={Tumorigenesis in glioblastoma multiforme (GBM) is complex and depends on interactions of tumor cells with the tumor microenvironment. A limiting factor in translating preclinical GBM treatment studies is being able to longitudinally and non-invasively map the tumor microenvironment in the same tumor over days and weeks. Here we describe a multi-modal MRI study of glioma growth and metabolism in human-derived models of GBM that differ in levels of hypoxia, angiogenesis and necrosis. We demonstrate successful longitudinal mapping of tumor growth and extracellular pH in the same U87 and U251 gliomas. We find that despite significant tumor growth, acidosis plateaus early.}
}
@inproceedings{ISMRM2018_3941,
annote={ISMRM2018_3941},
pages={3941},
file={ISMRM2018_3941.pdf:ISMRM2018_3941.pdf:PDF},
title={{MRI} for vitrectomized eyes},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3941.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jan-Willem Beenakker},
abstract={Retinal detachment is a common complication of ocular tumours and is treated by replacing the original vitreous liquid with a silicon oil (SiOil). This SiOil hinders regular ophthalmic imaging, preventing follow-up after radiotherapy. MRI could offer the necessary imaging, but the strong off-resonance of SiOil impedes normal scan protocols. We determined the MR-characteristics of SiOil and developed a corresponding MR-imaging protocol. This protocol was evaluated on an eye tumour patient, who also suffered from retinal detachment. The protocol resulted in high quality MR-images of the eye, allowed a diagnosis of the multiple ocular lesions and averted surgical removal of the eye.}
}
@inproceedings{ISMRM2018_3942,
annote={ISMRM2018_3942},
pages={3942},
file={ISMRM2018_3942.pdf:ISMRM2018_3942.pdf:PDF},
title={{DCE}-{MRI} with a targeted contrast agent for characterizing prostate cancer aggressiveness},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3942.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Zheng-Rong Lu and Zheng Han},
abstract={Conventional dynamic contrast-enhanced MRI (DCE-MRI) has been used for tumor characterization based on tumor vascularity and permeability using non-targeted small molecular contrast agents. In this study, we investigate the effectiveness of DEC-MRI with a targeted MRI contrast agent for characterization of prostate cancer of different aggressiveness in comparison with a clinical agent. Distinctive Ktrans and Ve values were obtained between the high-risk PC3 and low-risk LNCaP tumors using the targeted agent, but not for the clinical agent, Gd(HP-DO3A). DCE-MRI with this targeted contrast agent could increase accuracy in characterizing prostate cancer aggressiveness.}
}
@inproceedings{ISMRM2018_3943,
annote={ISMRM2018_3943},
pages={3943},
file={ISMRM2018_3943.pdf:ISMRM2018_3943.pdf:PDF},
title={{PET}/{MR} in tumor differentiation of head and neck squamous cell carcinoma: a Preliminary Study of Multi-modality Imaging including {PET}, {DWI}, {DCE} and the combination},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3943.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Haodan Dang and Yu Chen and Bo Hou and Huadan Xue and Zhengyu Jin},
abstract={The purpose of our study was to evaluate the diagnostic efficiency of multiple parameters and the combination with PET/MR in tumor differentiation of HNSCC. The patients with clinical suspicion or diagnosis of HNSCC were included and had the PET/MR examination with 18F-FDG PET and multiple MR sequences. The results showed that there was no significant correlation among different parameters. The differences among groups of tumor differentiation were obvious with ADCmean and SUVmean. Finally, our study suggested that the multiple parameters of PET / MR could be complementary in diagnosis of tumor differentiation and the combination can further improve the performance.}
}
@inproceedings{ISMRM2018_3944,
annote={ISMRM2018_3944},
pages={3944},
file={ISMRM2018_3944.pdf:ISMRM2018_3944.pdf:PDF},
title={Population variation in tumour microvascular characteristics},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3944.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ross A Little and Hervé Barjat and Jennifer I Hare and Mary Jenner and Yvonne Watson and Susan Cheung and Katherine Holliday and Weijuan Zhang and James PB O'Connor and Simon T Barry and Sanyogitta Puri and Geoff JM Parker and John C Waterton},
abstract={It is unclear from the literature whether microvascular characteristics vary according to primary tumour type, although this is important for e.g. patient selection in drug development. DCE-MRI data were obtained covering 342 tumours and 13 tumour types. Median K
trans for non-glioma tumours had geometric mean (95\% CI) of 0.15 min
-1 (0.05 min
-1, 0.45 min
-1). There was insufficient separation between posterior densities to predict tumour K
trans given primary tumour type. This demonstrates that where microvascular characteristics are relevant for inclusion in a clinical trial or for beginning a specific treatment, it is not generally possible to select on tumour type alone.}
}
@inproceedings{ISMRM2018_3945,
annote={ISMRM2018_3945},
pages={3945},
file={ISMRM2018_3945.pdf:ISMRM2018_3945.pdf:PDF},
title={The effect of sunitinib on human melanoma xenografts assessed with {MRI} and intravital microscopy},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3945.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jon-Vidar Gaustad and Trude G Simonsen and Einar K Rofstad},
abstract={We evaluated the effect of sunitinib on melanoma xenografts with dynamic contrast-enhanced MRI (DCE-MRI), diffusion weighted MRI (DW-MRI), intravital microscopy and immunohistochemistry. An MR-compatible dorsal window chamber was used to compare parametric MR images with high resolution intravital microscopy images of the tumor vasculature. Sunitinib treatment reduced vessel density, increased the hypoxic tumor fraction and induced necrosis and DCE-MRI and DW-MRI were sensitive to these microenvironmental effects. The MR-compatible window chamber allowed daily assessment of both the morphology and function of tumor vasculature and may be a valuable tool to verify treatment-induced effects observed in parametric MR images.}
}
@inproceedings{ISMRM2018_3946,
annote={ISMRM2018_3946},
pages={3946},
file={ISMRM2018_3946.pdf:ISMRM2018_3946.pdf:PDF},
title={{CEST} {MRI} of 3-O-Methyl-D-Glucose uptake and accumulation in brain tumors},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3946.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Akansha Ashvani Sehgal and Yuguo Li and Bachchu Lal and Nirbhay N Yadav and Xiang Xu and Jiadi Xu and John Laterra and Peter C. M van Zijl},
abstract={Glucose weighted chemical exchange saturation transfer (CEST) imaging has garnered a lot of interest in the past few years as it can be a safe alternative to gadolinium contrast based MRI for tumor diagnosis. 3-O-methyl glucose (3-OMG) is a structural analog of glucose which, because of its apparent non-toxicity and its property to not get metabolized, has been shown to be another promising CEST contrast agent. Here we explore its application as a CEST contrast agent for assessing brain tumors.}
}
@inproceedings{ISMRM2018_3947,
annote={ISMRM2018_3947},
pages={3947},
file={ISMRM2018_3947.pdf:ISMRM2018_3947.pdf:PDF},
title={Bio-orthogonal {MR} imaging – A novel method proposed for metastatic cancer detection},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3947.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Tanner Ravsten and William Pitt and Neal Bangerter and Randy Hartley and Forrest Howell and Jessica Doud},
abstract={Metastatic tumors (METs) cause 90\% of cancer deaths since their small size makes detection difficult. A bio-orthogonal method is demonstrated where two distinct detection molecules and mechanisms are employed with minimal interference. Gadolinium (Gd) and Iron-Oxide-Particles (IOP) with respective MRI T1 and T2* scans were hypothesized to produce orthogonality in the resulting images. In vitro experiments showed respective minimum detectability limits of Gd and IOP at 1µL, 0.25µM and 0.5µL, 6µM. Ex vivo experiments demonstrated Gd and IOP detection at 0.313-0.625mM. Thus the plausibility of bio-orthogonal MET detection to reduce the likelihood of false positive and negative diagnoses is very high.}
}
@inproceedings{ISMRM2018_3948,
annote={ISMRM2018_3948},
pages={3948},
file={ISMRM2018_3948.pdf:ISMRM2018_3948.pdf:PDF},
title={A 3D Spiral/Radial sequence for both anatomical and {DCE} imaging of pulmonary metastases in mice},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3948.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Emeline Julie RIBOT and Charles Castets and Wilfried Souleyreau and Lin Cooley and Andreas Bikfalvi and Aurélien Trotier and Sylvain Miraux},
abstract={In order to detect and characterize pulmonary metastases in small animals, a 3D UTE sequence using a hybrid radial/spiral encoding, was employed while free breathing. Due to the high contrast and the high spatial resolution (125μm isotropic), early-growing metastases (representing less than 10 voxels) were detected in mice in only 12min. In parallel, through the acceleration of the acquisition by 4, the same sequence was used to perform, for the 1st time, DCE-MRI on pulmonary metastases in mice. The new pulmonary-dedicated sequence enables to obtain either anatomical or DCE-MRI information in mice.}
}
@inproceedings{ISMRM2018_3949,
annote={ISMRM2018_3949},
pages={3949},
file={ISMRM2018_3949.pdf:ISMRM2018_3949.pdf:PDF},
title={Correlation of Native Liver T1 mapping to post contrast T1 mapping, Apparent Diffusion Coefficient ({ADC}) and Dynamic Contrast Enhancement ({DCE}) Maps in a Rabbit Model for Liver Cancer},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3949.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Dana C Peters and Daniel Coman and Julius Chapiro and John Walsh and Fahmeed Hyder and Tsa Shelton and Johanna van Breugel and Tabea Borde and Lynn Savic and MingDe Lin and Albert J Sinusas and Jean-Francois Geschwind and Douglas Rothman and R. Todd Constable and James S Duncan and Steffen Huber},
abstract={We investigated native T1 mapping for detection of liver tumors in comparison to multi-parametric MRI. In 13 rabbits with implanted 2 week VX2 tumor, 9 of which underwent transarterial chemoembolization (TACE), native T1 mapping showed a similar spatial pattern compared to dynamic contrast enhanced (DCE) imaging, apparent diffusion coefficient maps (ADC) and post-contrast T1 maps. Native T1 is highest in central necrosis, intermediate in viable hypervascular tumor and lowest in normal liver.}
}
@inproceedings{ISMRM2018_3950,
annote={ISMRM2018_3950},
pages={3950},
file={ISMRM2018_3950.pdf:ISMRM2018_3950.pdf:PDF},
title={Feature decomposition based examining tumor heterogenity on dynamic susceptibility contrast enhansed {MRI} data},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3950.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Bing Ji and Silun Wang and Liya Wang and Xiaofeng Yang and Hui Mao},
abstract={Dynamic susceptibility contrast-enhanced magnetic resonance imaging (DSC MRI) is widely used for studying blood perfusion in brain tumors. We report useof a model freeapproach combining with a feature extraction strategy to interrogate time course data from DSC MRI of brain tumor patients. The results reveal the spatial and temporal heterogenityof brain tumors based on features of time course profiles. The number of features/patterns in DSC data indicating theheterogenityof thetumor is associated with the tumor grade. The new method can potentially extract more tumor physiology information from DSC MRI comparing to the traditional model-based analysis.}
}
@inproceedings{ISMRM2018_3951,
annote={ISMRM2018_3951},
pages={3951},
file={ISMRM2018_3951.pdf:ISMRM2018_3951.pdf:PDF},
title={Magnetic targeting and imaging of super-paramagnetic iron-oxide nanoparticles to subcutaneous tumour models},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3951.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Mohammad Mohseni and John Connell and Stephen Patrick and Chris Payne and Yichao Yu and May Zaw-Thin and Tom Roberts and Bernard Siow and Tammy Kalber and Quentin Pankhurst and Mark Lythgoe},
abstract={Magnetic targeting of iron-oxide nanoparticles using a MRIsystem could play an important role forfuture advances in delivery and non-invasive monitoring of therapeutic interventions. Currently, there is limited information on the effect of magnetic field gradients on the distribution of particle accumulation in the target region. This study shows that the delivery of individual 100nm particles can be enhanced in tumours using an external magnetic field after intravenous injection in vivo. Using quantitative non-invasive imaging we found that the distribution of nanoparticles within the tumourdepends on the shape of the magnetic field gradient applied across the tumour.}
}
@inproceedings{ISMRM2018_3952,
annote={ISMRM2018_3952},
pages={3952},
file={ISMRM2018_3952.pdf:ISMRM2018_3952.pdf:PDF},
title={Androgen receptor signaling in castration resistant prostate cancer tumor alters real-time lactate flux and lactate levels in vivo},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3952.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Niki Zacharias and Jaehyuk Lee and Sumankalai Ramachandran and Sriram Shanmugavelandy and James McHenry and Sankar Maity and Mark Titus and Pratip Bhattacharya},
abstract={Non-invasive imaging of castration resistant prostate cancer (CRPC) subtypes remains a challenge in the clinic. CRPC can be subdivided grossly into two phenotypes 1) a morphologically small cell, chemosensitive and androgen receptor (AR) negative subtype and 2) AR-dependent CRPC characterized by dysregulation of AR signaling. Employing hyperpolarized pyruvate conversion to lactate in vivo as well as lactate measurements ex vivo, we determined the difference in glycolysis between patient derived xenograft (PDX) animal models of these two CRPC subtypes. We have found increased pyruvate to lactate conversion (P <0.04) and higher lactate levels in AR-dependent compared to AR negative PDX models.}
}
@inproceedings{ISMRM2018_3953,
annote={ISMRM2018_3953},
pages={3953},
file={ISMRM2018_3953.pdf:ISMRM2018_3953.pdf:PDF},
title={Comparison of 2D and 3D dynamic contrast enhanced perfusion magnetic resonance imaging in patients with colorectal cancer},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3953.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Tanja Uhrig* and Christina Korth* and Sonja Sudarski and Lothar R. Schad and Frank G. Zöllner},
abstract={This study investigated the influence of quantitative 3D volume dynamic contrast enhanced-MRI in rectal cancer on perfusion parameters compared to the data obtained by a selecting a single tumor slice as typically performed in clinical routine. Data analysis of five patients showed deviations of up to 28 \% for Plasma Flow, 28 \% for Plasma Volume and 36 \% for Mean Transit Time. An examination of the entire tumor volume is therefore advisable in order to additionally guarantee intra-observer reproducibility.}
}
@inproceedings{ISMRM2018_3954,
annote={ISMRM2018_3954},
pages={3954},
file={ISMRM2018_3954.pdf:ISMRM2018_3954.pdf:PDF},
title={In vivo monitoring of oxygen levels in the brain tumor between fractionated radiotherapy using oxygen-enhanced {MR} imaging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3954.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Junchao Qian and Xiang Yu and Suhong Wu and Hongzhi Wang},
abstract={Response of tumor cells to radiation is closely related to oxygen level and fractionated radiotherapy allows reoxygenation of hypoxic tumor cells. Dynamic monitoring of tissue oxygenation is important for precise radiotherapy. Oxygen-enhanced MRI may directly reflect tissue oxygenation, has shown promising applications in the measurement of hypoxia. Therefore, in this study we explored the possibility to monitor oxygen level in the brain between fractionated radiotherapy using oxygen-enhanced MRI. The results showed ΔR
1 increased in tumor 30 minutes after first fractionated radiation compared to pre-radiation levels. Thus, oxygen-enhanced MRI can noninvasively monitor oxygen levels in brain tumor between fractionated radiotherapy.}
}
@inproceedings{ISMRM2018_3955,
annote={ISMRM2018_3955},
pages={3955},
file={ISMRM2018_3955.pdf:ISMRM2018_3955.pdf:PDF},
title={Variation-guided supervoxels for subregional tumour analysis in {DCE}-{MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3955.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jola Mirecka and Benjamin Irving and Danny Allen and Paul Kinchesh and Stuart Gilchrist and Ana Gomes and Veerle Kersemans and Sean Smart and Michael Chappell and Julia Schnabel and Mark Jenkinson},
abstract={In nature and real life application domains it is common to encounter varied or textured areas, therefore in many cases it is of greater interest to partition the image into similarly varied, as opposed to similarly homogeneous subregions. We propose a novel, variation-guided approach to SLIC clustering, that has a potential to provide a useful alternative to standard supervoxels due to it’s ability to retain local variation information. We evaluate the method on a longitudinal DCE-MRI dataset of 10 mice scanned over 10 days. The method was able to produce contiguous segmentations, while significantly reducing computational complexity.}
}
@inproceedings{ISMRM2018_3956,
annote={ISMRM2018_3956},
pages={3956},
file={ISMRM2018_3956.pdf:ISMRM2018_3956.pdf:PDF},
title={Hypoxia in Rat Prostate Tumors: Correlation of {BOLD}/{TOLD} {MRI} with [18F]{FMISO} {PET}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3956.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Heling Zhou and Srinivas Chiguru and Rami Hallac and Donghan M Yang and Guiyang Hao and Peter Peschke and Ralph P Mason},
abstract={
18F-fluoromisonidazole ([
18F]FMISO) has been exploited in positron emission tomography (PET) as an imaging radiotracer for tumor hypoxia. The accumulation of [
18F]FMISO must depend on both hypoxia and perfusion. In this study, we investigated [
18F]FMISO activity in the AT1 tumor rat model and found that [
18F]FMISO produced conflicting results in the poorly perfused hypoxic tumors. The preliminary results indicate that BOLD and TOLD MRI can provide complimentary information for interpretation of the [
18F]FMISO results.}
}
@inproceedings{ISMRM2018_3957,
annote={ISMRM2018_3957},
pages={3957},
file={ISMRM2018_3957.pdf:ISMRM2018_3957.pdf:PDF},
title={Assessment of tumors aggressiveness in papillary thyroid cancer ({PTC}) using {DCE}-{MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3957.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ramesh Paudyal and Yonggang Lu and Vaios Hatzoglou and David Aramburu Nunez and Andre Moreira and Yousef Mazaheri and Mithat Gonen and Joseph O. Deasy and Ashok Shaha and R. Michael Tuttle and Amita Shukla-Dave},
abstract={In this study, pretreatment dynamic contrast enhanced (DCE-MRI) data was analyzed using the Tofts model (TM), extended Tofts model (ETM) and two compartment exchange model (2CXM) to quantify perfusion-related quantitaive imaging metrics in papillary thyroid cancer (PTC) patients. The histopathological features of aggressiveness were used as the standard of reference. The results indicated that the ETM provided better fit among the models. The ETM Ktrans values were able to distinguish between aggressive and non-aggressive tumors. The study concludes that pretreatment perfusion-related metric can be useful biomarkers for stratifying tumor aggressiveness in PTC patients.}
}
@inproceedings{ISMRM2018_3958,
annote={ISMRM2018_3958},
pages={3958},
file={ISMRM2018_3958.pdf:ISMRM2018_3958.pdf:PDF},
title={Iron Oxide-Based T2-weighted {MRI} and {NMR} Metabolomics of Radiation and Chemotherapy Induced Inflammation in Glioma Models},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3958.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Heather Caulkins and Paul Hong and Ksenia Serdukova and Kendra Huber and Denise Davis and Jenna Steiner and Natalie Julie Serkova},
abstract={Radio- and chemotherapy for gliomas cause a macrophage-driven inflammation called pseudoprogression (PsP) which appears as abnormal MRI enhancement mimicking treatment response. Our quantitative NMR metabolomics in murine glioma models show a significant increase in amino acid uptake and metabolism (glutamine, glycine, methionine and tyrosine), lactate and phospholipids in actively proliferating untreated gliomas. Iron oxide is taken up uniquely by inflammatory macrophages, as shown by decreased T2-MRI contrast and an increase in the F4/80 macrophages during treatment-induced PsP. This imaging platform may provide a promising discernment of PsP (iron oxide qT2MRI) and true progression (amino acid PET) for gliomas.
}
}
@inproceedings{ISMRM2018_3959,
annote={ISMRM2018_3959},
pages={3959},
file={ISMRM2018_3959.pdf:ISMRM2018_3959.pdf:PDF},
title={Simultaneous Measurement of Glutamate, Glutamine, {GABA} and Glutathione by Spectral Editing Without Subtraction},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3959.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Li An and Jun Shen},
abstract={A novel spectral editing approach was proposed to simultaneously measure glutamate, glutamine, GABA and glutathione at 7 T. By using a single editing pulse, a relatively short echo time of 56 ms was achieved. The main targets of the signal detection were the H2 and H4 protons of GABA and the H4 protons of glutamate, glutamine and the glutamyl moiety of glutathione. No motion-sensitive data subtraction was required.}
}
@inproceedings{ISMRM2018_3960,
annote={ISMRM2018_3960},
pages={3960},
file={ISMRM2018_3960.pdf:ISMRM2018_3960.pdf:PDF},
title={High-Speed Density Matrix Simulation of {PRESS} with A Single Editing Pulse},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3960.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Li An and Jun Shen},
abstract={A single spectral editing pulse incorporated into the PRESS sequence produces large Bloch-Siegert shift. The lack of a general method to quantify these shifts for spectral editing experiments has made it necessary to use a second identical editing pulse to cancel the shift. Here we describe a high-speed density matrix simulation method to accurately simulate a PRESS sequence with a single editing pulse for simultaneous detection of glutamate, glutamine, GABA and glutathione at TE = 56 ms and 7 Tesla. To facilitate in vivo quantification, the frequency dependent Bloch-Siegert shift is accurately calculated and removed from the spectra.}
}
@inproceedings{ISMRM2018_3961,
annote={ISMRM2018_3961},
pages={3961},
file={ISMRM2018_3961.pdf:ISMRM2018_3961.pdf:PDF},
title={Simultaneous edited {MR} spectroscopy of glutathione and macromolecule-suppressed {GABA}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3961.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Georg Oeltzschner and Kimberly L. Chan and Muhammad G. Saleh and Mark Mikkelsen and Nicolaas A. J. Puts and Richard A. E. Edden},
abstract={γ-aminobutyric acid (GABA) and glutathione (GSH) can be simultaneously measured in the human brain in vivo at 3T using Hadamard encoding and reconstruction of MEGA-edited spectroscopy (HERMES). A drawback of conventional HERMES of GABA/GSH is the contamination of the edited GABA peak with co-edited macromolecular signals (MM), reducing the specificity of the method. We propose the addition of symmetrical suppression into the HERMES framework and demonstrate the successful implementation of this approach in ten healthy subjects.}
}
@inproceedings{ISMRM2018_3962,
annote={ISMRM2018_3962},
pages={3962},
file={ISMRM2018_3962.pdf:ISMRM2018_3962.pdf:PDF},
title={Editing everything with {HERCULES}: Hadamard-encoded editing of seven low-concentration metabolites},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3962.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Georg Oeltzschner and Daniel Rimbault and Mark Mikkelsen and Muhammad G. Saleh and Nicolaas A. J. Puts and Richard A. E. Edden},
abstract={Low-concentration metabolites can be detected at 3T with J-difference-edited MR spectroscopy. However, long acquisition times (~10 min per metabolite) make edited studies of many metabolites unfeasible. Multiplexed editing experiments have increased the time efficiency of editing while maintaining its specificity. Here, we introduce HERCULES (Hadamard Editing Resolves Chemicals Using Linear-combination Estimation of Spectra), an advanced multiplexed approach to differentiate the evolution of eight editable spin systems (GABA, GSH, Asp, Asc, NAA, NAAG, Lac and 2-HG) within a single experiment. HERCULES quantifies a total number of 13 metabolites, providing a 7T-like neurochemical profile of neurotransmitters, antioxidants and metabolic markers at 3T.}
}
@inproceedings{ISMRM2018_3963,
annote={ISMRM2018_3963},
pages={3963},
file={ISMRM2018_3963.pdf:ISMRM2018_3963.pdf:PDF},
title={Bilateral functional {MRS} of {GABA} with real-time frequency and motion correction at 7T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3963.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Anouk Marsman and Vincent Oltman Boer and Mads Andersen and Esben Thade Petersen},
abstract={Brain function is largely controlled by inhibitory processes steered by main inhibitory neurotransmitter GABA. In this role, GABA is essential in brain development and plasticity as well as neuropsychiatric and neurodegenerative diseases. In order to accurately measure GABA responsiveness, we designed a bilateral edited fMRS sequence including real-time frequency and motion correction, as the relatively weak GABA signal is highly susceptible to frequency drift and motion. As acquisition of the macromolecule-uncontaminated GABA signal is challenging at lower field strengths, experiments were performed at 7T.}
}
@inproceedings{ISMRM2018_3964,
annote={ISMRM2018_3964},
pages={3964},
file={ISMRM2018_3964.pdf:ISMRM2018_3964.pdf:PDF},
title={Test-retest reproducibility of quantitative proton {MRS} using short-{TE} {STEAM} and semi-{LASER} sequences in young adult volunteer brains at 7T.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3964.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Tomohisa Okada and Hideto Kuribayashi and Lana G Kaiser and Yuta Urushibata and Nouha Salibi and Ravi Teja Seethamraju and Sinyeob Ahn and Tadashi Isa and Koji Fujimoto},
abstract={Recently, 7T-MR system has been approved for clinical use in Europe and USA; however, its clinical configuration is limited to single-channel transmit so B1+ shimming is not feasible. This study investigated reproducibility of single-voxel MRS using short-TE STEAM and semi-LASER using a single-transmit \& 32-receiver head coil at 7T. Fifteen healthy young volunteers were scanned twice at the posterior cingulate. SNR was higher in semi-LASER, but coefficients of variation were comparable ranging mainly from 5-10\% and better in short-TE STEAM in low-concentration J-coupled peaks. Even with clinical setups, 7T shows high reliability and will contribute to MRS investigation.}
}
@inproceedings{ISMRM2018_3965,
annote={ISMRM2018_3965},
pages={3965},
file={ISMRM2018_3965.pdf:ISMRM2018_3965.pdf:PDF},
title={Impact of sub-echo timings of {PRESS} on quantitative glutamate/glutamine level using {LCM}odel at 7T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3965.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Tzu-Jung Fei and Cheng-Wen Ko and Moritz Braig and Jochen Leupold},
abstract={In this study, we investigated the signal variation of Glu and Gln along sub-echo timings (TE1, TE2) in PRESS acquisitions on a preclinical 7T system. Our results show that the choice of sub-echo timings (TE1, TE2) for PRESS may alter the quantitative outcome remarkably for strongly coupled metabolites, e.g. Glu, Gln. The basis-sets used for LCModel analysis has to be carefully simulated and take the sub-echo timings into account since J-evolution of strongly coupled resonances may vary with TE1/TE2 at high fields. Quantitative comparison on these metabolites with mismatched sub-echo timings (TE1, TE2) can result in invalid conclusion.}
}
@inproceedings{ISMRM2018_3966,
annote={ISMRM2018_3966},
pages={3966},
file={ISMRM2018_3966.pdf:ISMRM2018_3966.pdf:PDF},
title={Non-water Suppressed {GABA} Edited Magnetic Resonance Spectroscopic Imaging using Density Weighted Concentric Rings k-space Trajectory},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3966.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Uzay E Emir and Pingyu Xia and Xiaopeng Zhou and Mark Chiew and Adam Steel and M Albert Thomas and Ulrike Dydak},
abstract={In this study, we have developed and demonstrated a non-water suppressed GABA editing Magnetic Resonance Spectroscopic Imaging technique using density-weighted concentric rings k-space trajectory that performs robustly within a clinically feasible acquisition time at 3T. The method has been validated in a series of phantom experiments and its feasibility assessed in a healthy volunteer with a high in-plane resolution of 7.5 × 7.5 mm
2. Experiments qualitatively demonstrate the advantage of the proposed method in terms of its improved resolution and reduced contamination of spectra from neighboring voxels.}
}
@inproceedings{ISMRM2018_3967,
annote={ISMRM2018_3967},
pages={3967},
file={ISMRM2018_3967.pdf:ISMRM2018_3967.pdf:PDF},
title={Automated {MR} Spectrum Registration for In Vivo Mouse {MEGA}-{PRESS} Study at 9.4T And the Introduction of {MRSM}ouse2.0},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3967.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jia Guo and Douglas L. Rothman and Scott A. Small},
abstract={The goal of this study was to develop the tailored automated processing and quantification software for Meshcher–Garwood point resolved spectroscopy (MEGA-PRESS) in research of mouse models at 9.4T. The proposed software, MRSMouse, consists of two modules: the data loading module, MRSMouseLoad, which reads the Bruker time-domain raw data and processes it into a frequency-domain GABA-edited spectrum with bandwidth, frequency and phase drift correction through spectrum registration; and the spectral fitting module, MRSMouseFit, which quantifies the metabolite concentrations by modeling the spectra as a linear combination of the simulated basis-set and a smooth-spline in the frequency domain.}
}
@inproceedings{ISMRM2018_3968,
annote={ISMRM2018_3968},
pages={3968},
file={ISMRM2018_3968.pdf:ISMRM2018_3968.pdf:PDF},
title={Comparison of {GABA} and Glx Quantification from Edited and Unedited {MR} Spectra – assessment of age effects},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3968.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Akila Weerasekera and Diana Sima and Ronald Peeters and Tom Dresslaers and Oron Levin and Stephan Swinnen and Sabine Van Huffel and Uwe Himmelreich},
abstract={1H-MR spectroscopy (MRS) is a well-established tool to provide in vivo measurement of gamma-aminobutyric acid (GABA), glutamine and glutamine (Glx) concentrations for a variety of conditions1. There is an increasing interest in using spectral editing methods to measure GABA and Glx in the human brain. The commonly used GABA-editing sequence MEGA-PRESS provides filtered GABA signals based on the molecule’s J-coupling2, 3. Nonetheless, quantitative comparison among presently used acquisition and analysis methods is lacking. Here we compare currently available spectral fitting methods to assess the in vivo concentration values for GABA and Glx derived from edited (MEGA-PRESS) and unedited (MEGA-PRESS-OFF) spectra. We have tested our approach to assess the inter-subject variability in neurotransmitter levels arising from age effects.}
}
@inproceedings{ISMRM2018_3969,
annote={ISMRM2018_3969},
pages={3969},
file={ISMRM2018_3969.pdf:ISMRM2018_3969.pdf:PDF},
title={Towards repeatable {GABA}-{MRS} of the hippocampus: Development of an extended post-processing pipeline},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3969.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yannik Völzke and Eberhard D. Pracht and Elke Hattingen and Tony Stöcker},
abstract={The low concentration and the overlap with more prominent resonances hamper the GABA quantification via MR spectroscopy. Strong B0 inhomogeneities in the hippocampus further impede reliable spectroscopic measurements. To increase the repeatability of the GABA quantification we developed a post-processing module for MEGA-sLASER measurements.The development of an optimized post-processing module reduces the coefficient of variation of the intra-session GABA/creatine signal ratio to (5-10)\%. This is essential for clinical trials.}
}
@inproceedings{ISMRM2018_3970,
annote={ISMRM2018_3970},
pages={3970},
file={ISMRM2018_3970.pdf:ISMRM2018_3970.pdf:PDF},
title={Simulations of {MEGA}-{PRESS} spectra to achieve quality criteria for {GABA} quantification},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3970.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Helge Jörn Zöllner and Alfons Schnitzler and Hans-Jörg Wittsack},
abstract={The purpose of this study was to investigate the influence of diminished spectral quality on GABA quantification by using MEGA-PRESS simulations. Different levels of spectral quality were created by adding artificial noise and line broadening to a simulated spectrum to mimic shimming quality. Initial results revealed that the impact of signal to noise ratio (SNR) is much higher than the impact of line broadening. Furthermore the error of peak fitting does not seem to reflect the real quantification error of the known GABA levels of the simulated spectrum. Further simulations and analyses are needed to assure these initial results.}
}
@inproceedings{ISMRM2018_3971,
annote={ISMRM2018_3971},
pages={3971},
file={ISMRM2018_3971.pdf:ISMRM2018_3971.pdf:PDF},
title={Spectral simulations of glutathione at 7T: Comparison of two different spin system parameter sets},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3971.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Muhammad Gulamabbas Saleh and Mark Mikkelsen and Georg Oeltzschner and Kimberly L. Chan and Adam Berrington and Peter B. Barker and Richard A. E. Edden},
abstract={Glutathione (GSH) is a redox compound, providing protection against reactive oxygen species. Abnormal variation in GSH concentration has been associated with several neurological diseases. Several studies quantify low-concentration metabolites, such as GSH, using simulated basis sets derived from spin system parameters available in the literature. Through simulations and phantom experiments, we assess the accuracy of two different sets of spin system parameters of GSH-cysteine at 7T. The disagreement between the phantom and simulation GSH-cysteine spectra suggests a need for further refinement of the spin system parameters.}
}
@inproceedings{ISMRM2018_3972,
annote={ISMRM2018_3972},
pages={3972},
file={ISMRM2018_3972.pdf:ISMRM2018_3972.pdf:PDF},
title={Simultaneous editing of {GABA} and glutathione at 7T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3972.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Muhammad Gulamabbas Saleh and Mark Mikkelsen and Georg Oeltzschner and Kimberly L. Chan and Adam Berrington and Peter B. Barker and Richard A. E. Edden},
abstract={HERMES has been shown to simultaneously edit GABA and GSH at 3T. Spectral editing at 7T provides better editing pulse selectivity, e.g. quantifying GABA with less contamination from macromolecules. In this abstract, simulations, phantom and in vivo experiments were performed at 7T using the sLASERsequence for simultaneous editing of GABA and GSH using HERMES. HERMES with sLASERlocalization at 7T provides uniform localization, doubles the acquisition rate and provides excellent separation of the metabolites without any loss in spectral quality compared to sequentially acquired measurements of GABA and GSH using MEGA-PRESS.}
}
@inproceedings{ISMRM2018_3973,
annote={ISMRM2018_3973},
pages={3973},
file={ISMRM2018_3973.pdf:ISMRM2018_3973.pdf:PDF},
title={High Spatial Resolution Simulated Basis Sets for {HERMES} and {MEGA}-{PRESS}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3973.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Diana Georgiana Rotaru and David John Lythgoe},
abstract={Low concentration metabolites with J-coupled peaks are difficult to quantify using MRS, even using MEGA-PRESS or its recently propose HERMES implementation. Using LCModel with simulated basis sets can lead to inaccurate metabolite quantification, since the spatial-dependence of the signal is often not fully accounted for. This can be minimised by increasing the number of spatial positions simulated, at the expense of computation time. We simulated basis sets for MEGA-PRESS and HERMES using the recently introduced approach based on one-dimension projections, as a replacement for the commonly used three-dimensional method, providing more accurate basis sets in shorter computation time.}
}
@inproceedings{ISMRM2018_3974,
annote={ISMRM2018_3974},
pages={3974},
file={ISMRM2018_3974.pdf:ISMRM2018_3974.pdf:PDF},
title={Multi-Step Frequency-and-Phase Correction for Multiplexed Edited {MRS} Data},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3974.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Mark Mikkelsen and Muhammad G. Saleh and Jamie Near and Kimberly L. Chan and Tao Gong and Ashley D. Harris and Georg Oeltzschner and Nicolaas A. J. Puts and Kim M. Cecil and Iain D. Wilkinson and Richard A. E. Edden},
abstract={Multiplexed edited MRS – more than one edited experiment combined in a single acquisition – involves acquiring subspectra with four or more distinct signal profiles. This technique therefore requires a tailored approach for correcting frequency and phase errors associated with participant head motion and scanner instability. Here, we demonstrate a novel alignment algorithm, termed multi-step frequency-and-phase correction (msFPC), designed to deal with the challenges of aligning individual transients in multiplexed edited data. Testing this method on simulated and in vivo datasets, msFPC was found to outperform other previously demonstrated algorithms (spectral registration and spectral registration with post hoc choline-creatine alignment).}
}
@inproceedings{ISMRM2018_3975,
annote={ISMRM2018_3975},
pages={3975},
file={ISMRM2018_3975.pdf:ISMRM2018_3975.pdf:PDF},
title={Scan Duration, Signal-To-Noise Ratio and Sample Size Considerations in {GABA}-Edited {MRS} Studies},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3975.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Mark Mikkelsen and Rachelle S. Loo and Nicolaas A. J. Puts and Richard A. E. Edden and Ashley D. Harris},
abstract={We investigate the relationships between scan duration, signal-to-noise ratio (SNR) and group-level variance in GABA-edited MRS. Typically, GABA editing takes ~10 min for a 27-mL voxel. GABA+/Cr measurements from five voxels from 18 participants were analyzed by cumulatively binning the averages within each dataset to determine the effects on SNR and group-level variance. Sample size calculations estimated the required sample sizes needed for different predicted effect sizes in GABA-edited MRS studies. We show that the duration of GABA-edited acquisitions can be reduced if taking into account a statistically acceptable amount of group-level variance and the magnitudes of predicted effects.}
}
@inproceedings{ISMRM2018_3976,
annote={ISMRM2018_3976},
pages={3976},
file={ISMRM2018_3976.pdf:ISMRM2018_3976.pdf:PDF},
title={Optimal phased-array signal combination from separate coil elements for {GABA} quantification at 7T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3976.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Donghyun Hong and Seyedmorteza Rohani Rankouhi and Jan-Willem Thielen and David G. Norris},
abstract={Hitherto, signal combination strategies from separate coil elements have been evaluated on the basis of spectral SNR improvement. This study compared various combination methods for two representative GABA measurement techniques: GABA editing and short echo time acquisitions and investigated which signal combination method is optimal in terms of GABA quantification using LCModel.}
}
@inproceedings{ISMRM2018_3977,
annote={ISMRM2018_3977},
pages={3977},
file={ISMRM2018_3977.pdf:ISMRM2018_3977.pdf:PDF},
title={Feasibility of ultra-short {TE} {MRS} with full intensity to detect human brain glutathione, glutamine and {GABA} on 3 T and 4 T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3977.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Xi Chen and Yihong Yang and Dost Ongur and Fei Du},
abstract={GABA, glutamine (Gln) and Glutathione (GSH) are important metabolites in human brain. However, with regular proton MRS, all of them are subject to J modulations during the moderate TE and hardly reliably observed. This study utilizes SPECIAL, an ultra-short TE MRS with full intensity, on 3T and 4T human scanners to test its feasibility to detect GABA, Gln and GSH. Compared to 3T PRESS, SPECIAL on 3T and 4T observed consistent Gln and GSH concentrations with higher reliabilities. Uniquely, 4T SPECIAL observed GABA+MM signal with significantly lower CRLB compared to 3 T measurements.}
}
@inproceedings{ISMRM2018_3978,
annote={ISMRM2018_3978},
pages={3978},
file={ISMRM2018_3978.pdf:ISMRM2018_3978.pdf:PDF},
title={Increased Rostral Anterior Cingulate Cortex {GABA}+ Concentrations in {IBS} Patients with Anxiety},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3978.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Sofie Tapper and Adriane Icenhour and Olga Bednarska and Anders Tisell and Susanna Walter and Peter Lundberg},
abstract={The aim was to investigate whether Glutamate and GABA concentrations were altered in the rACC in patients with IBS compared to healthy controls and to investigate if the GABA and Glutamate concentrations were associated with the level of anxiety in IBS patients. We observed higher rACC GABA+ concentrations in IBS patients, whereas Glx concentrations remained unaltered. Moreover, the changes in GABA concentrations were most pronounced in patients with high severity of anxiety. Thus, our findings provide first evidence of dysregulated rACC GABAergic neurotransmission in IBS and suggest that altered inhibitory neurotransmission may be linked to comorbid anxiety in IBS patients.}
}
@inproceedings{ISMRM2018_3979,
annote={ISMRM2018_3979},
pages={3979},
file={ISMRM2018_3979.pdf:ISMRM2018_3979.pdf:PDF},
title={Macromolecule Suppressed {GABA} Editing with Reduced Artifact in Region near Sinuses using Improved {MEGA}-{SPECIAL} Sequence},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3979.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Meng Gu and Ralph Hurd and Laima Baltusis and Frederick T. Chin and Daniel M. Spielman},
abstract={B0-inhomogeneity-insensitive GABA editing with MM suppression has been developed using improved MEGA-SPECIAL sequence using highly selective (30 ms) editing pulses allowed by 1D ISIS localization and 1D echo planar gradient in the logical S/I direction. MM suppressed GABA editing was successfully achieved in occipital lobe. However, GABA editing in regions near sinuses, e.g. anterior cingulate cortex (ACC), was compromised from imperfect subtraction in the ISIS localization. To reduce artifact in this region, the ISIS and 1D EP gradient were applied in the logical R/L direction together with a 16-step phase-cycled acquisition. These methods significantly improved edited spectra obtained from ACC.}
}
@inproceedings{ISMRM2018_3980,
annote={ISMRM2018_3980},
pages={3980},
file={ISMRM2018_3980.pdf:ISMRM2018_3980.pdf:PDF},
title={Frequency-dependent cortical plasticity via {GABA} modulation},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3980.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Caroline Lea-Carnall and Faezeh Sanaei Nezhad and Nelson Trujillo-Barreto and Marcelo A Montemurro and Wael El-Deredy and Laura M Parkes},
abstract={Gamma-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in the human brain and is thought to underlie plasticity processes. We tested the effect of repetitive tactile stimulation using two driving frequencies on GABA concentration using functional magnetic resonance spectroscopy (fMRS) and psychophysics testing. We were able to detect changes within a single scan session at 3 Tesla (3T) and relate these to well-established behavioural markers of plastic change demonstrating the utility of fMRSas a novel tool to understand the mechanisms of plasticity and the efficacy of therapeutic treatments.}
}
@inproceedings{ISMRM2018_3981,
annote={ISMRM2018_3981},
pages={3981},
file={ISMRM2018_3981.pdf:ISMRM2018_3981.pdf:PDF},
title={Effect of {DRD}4 receptor −616 C/G polymorphism on thalamic {GABA} levels in pediatric primary nocturnal enuresis patients},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3981.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yi You and Zijun Li and Xiaoqi Wang and Bing Yu},
abstract={The objective of this study is to explore the effect of DRD4 −616 C/G single nucleotide polymorphism (SNP) on thalamic GABA levels in with primary nocturnal enuresis (PNE). Results indicates the DRD4 −616 C allele is associated with increased thalamic GABA levels and higher arousal from sleep (AS) scores in PNE children. This research helps us understand the genetic susceptibility of the DRD4 −616 C allele to PNE.}
}
@inproceedings{ISMRM2018_3982,
annote={ISMRM2018_3982},
pages={3982},
file={ISMRM2018_3982.pdf:ISMRM2018_3982.pdf:PDF},
title={Baseline {GABA} Concentration Predicts Treatment Response to Selective Serotonin Reuptake Inhibitors in Major Depressive Disorder},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3982.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Xiang He and Kenneth T Wengler and Greg Perlman and Elizabeth Bartlett and Christine DeLorenzo},
abstract={Major depressive disorder (MDD) affects more than 350 million people world-wide. Large heterogeneities in patient symptoms has led to several different treatment courses. Although treatments, such as SSRIs, are generally effective, a large portion of patients (~30\%) do not achieve remission. The ability to predict which treatment option will yield the best outcome would be of great use to clinicians and patients. The GABAergic system is implicated in MDD and affected by SSRIs. In this study GABA concentrations were measured with MEGA-PRESS MRS in MDD patients before and after treatment with a SSRI to determine predictive ability and treatment changes.
}
}
@inproceedings{ISMRM2018_3983,
annote={ISMRM2018_3983},
pages={3983},
file={ISMRM2018_3983.pdf:ISMRM2018_3983.pdf:PDF},
title={Relative quantification of the 23Na {MRI} signal of human intervertebral lumbar discs},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3983.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Stephan Gruber and Stefan Zbyn and Thomas Stulnig and Wolfgang Bogner and Siegfried Trattnig and Lenka Minarikova},
abstract={
23Na MRI was applied in five healthy volunteers to determine the feasibility of intervertebral discs sodium signal quantification using the cerebrospinal fluid signal from the spinal column as an internal reference. There were no significant differences between the five measured volunteers, or between the different discs (L1/2 – L5/S1), that were analysed. Therefore, internal referencing using CSF has the potential for sodium content quantification in intervertebral discs, which may be used as an indicator of disc degeneration.}
}
@inproceedings{ISMRM2018_3984,
annote={ISMRM2018_3984},
pages={3984},
file={ISMRM2018_3984.pdf:ISMRM2018_3984.pdf:PDF},
title={23{NA}-{MRI} of the skeletal muscle and skin in patients with adrenal insufficiency},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3984.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Andreas Max Weng and Stephanie Burger-Stritt and Irina-Oana Chifu and Martin Christa and Bernhard Petritsch and Thorsten Alexander Bley and Herbert Köstler and Stefanie Hahner},
abstract={Patients with chronic primary adrenal insufficiency require life-long glucocorticoid- and mineralocorticoid- replacement therapy. Monitoring of treatment is mainly based on clinical parameters and additional measurement of electrolyte status and plasma renin levels. However, obtained values often do not correspond to the patients’ subjective well-being and thus may not fully reflect optimal treatment. The present study investigated sodium content in the calf muscle and the skin obtained via
23Na-MRI in patients with chronic primary AI and healthy controls. Sodium content assessed by
23Na-MRI correlates with further parameters of mineralocorticoid activity and may serve as an objective method to monitor hormone substitution therapy in patients with adrenal insufficiency.}
}
@inproceedings{ISMRM2018_3985,
annote={ISMRM2018_3985},
pages={3985},
file={ISMRM2018_3985.pdf:ISMRM2018_3985.pdf:PDF},
title={Electrophysiological stimulation of excised rat muscle elicits a measurable change in tissue sodium concentration using 23Na-{MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3985.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Frank Riemer and Joshua Kaggie and Cormac O'Neill and Mary McLean and James Grist and Myfanwy Hill and Joe Guy and Rolf Schulte and Martin Graves and James Fraser and Ferdia Gallagher},
abstract={Changes in the tissue sodium gradient play an important role in cell signalling such as at the neuromuscular junction and as part of neuronal action potentials.
23Na-MRI has the ability to measure the macroscopic sodium distribution. In this study we investigated the changes in tissue sodium in an electrically stimulated and freshly excised rat leg muscle.}
}
@inproceedings{ISMRM2018_3986,
annote={ISMRM2018_3986},
pages={3986},
file={ISMRM2018_3986.pdf:ISMRM2018_3986.pdf:PDF},
title={Comparison of quantitative imaging methods of sodium concentration in leg muscle},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3986.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ryan J. Larsen and Luis M Perez and Kenneth R. Wilund and Theodore C. Claiborne and Brad P. Sutton},
abstract={Quantitative imaging of tissue sodium content requires corrections for coil loading. This can be done by introducing external calibration standards within the scan, or by employing the principle of reciprocity to normalize the signal by the voltage required to obtain a signal maximum. A direct comparison of these two quantification methods shows that they are highly consistent.}
}
@inproceedings{ISMRM2018_3987,
annote={ISMRM2018_3987},
pages={3987},
file={ISMRM2018_3987.pdf:ISMRM2018_3987.pdf:PDF},
title={Mapping Brain Tissue Sodium Parameters Using Fast 3D Multi-Echo Radial Imaging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3987.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jinhu Xiong and William R Kearney and Ankit Parekh and Mathews Jacobs and Rolf Schulte and Baolian Yang and Vincent A Magnotta},
abstract={We have developed 3D Multi-Echo Radial Imaging and Tikhonov reconstruction techniques for mapping brain tissue sodium concentration and R2* relaxation rate. The total acquisition time is about 6 minutes. Intra- and inter-cellular sodium concentrations and R2* relaxation rates were simultaneous estimated. Our long term aim is to develop 23Na imaging techniques for studies of brain function and diseases.}
}
@inproceedings{ISMRM2018_3988,
annote={ISMRM2018_3988},
pages={3988},
file={ISMRM2018_3988.pdf:ISMRM2018_3988.pdf:PDF},
title={31P {MRS} of the frontal lobe of human brain at 7T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3988.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Shizhe Steve Li and Li An and Jan Willem van der Veen and Maria Ferraris Araneta and Johnson Christopher and Yu Shao and Shumin Wang and Jun Shen and Jun Shen},
abstract={The majority of neuropsychiatric disorders are thought to be originated in the frontal lobe. Increasing the SNR of frontal lobe
31P MRS using a surface coil can be very important because many MRS manifestations of psychiatric illnesses could be subtle. This study demonstrates the feasibility of high SNR
31P MRS of human frontal lobe using a surface coil and 3D CSI at 7 Tesla. Comparing to the occipital lobe spectra acquired from the same subject it was shown that the sensitivity and spectral resolution of
31P MRS spectra of the frontal lobe can be made comparable to that of the occipital lobe.}
}
@inproceedings{ISMRM2018_3989,
annote={ISMRM2018_3989},
pages={3989},
file={ISMRM2018_3989.pdf:ISMRM2018_3989.pdf:PDF},
title={Influence of {BMI} and hepatic lipids on absolute quantification of 31P metabolites at 7T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3989.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Lorenz Pfleger and Martin Gajdošík and Peter Wolf and Sabina Smajiš and Paul Fellinger and Sigfried Trattnig and Michael Krebs and Marek Chmelík and Martin Krššák},
abstract={This study focuses on absolute quantification of hepatic
31P metabolites at ultra-high field (7T) and the possible influence of BMI and hepatocellular content of lipids (HCL) on the calculated metabolite concentrations. Significant differences were found in γ- and α-ATP as well as in P
i content for population groups with normal and high BMI. With the assessment of HCL it is possible to correct for those differences and no significances could be reported after.}
}
@inproceedings{ISMRM2018_3990,
annote={ISMRM2018_3990},
pages={3990},
file={ISMRM2018_3990.pdf:ISMRM2018_3990.pdf:PDF},
title={Unambiguous detection of cardiac Pi using long {TM} 31P {STEAM}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3990.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Albrecht Ingo Schmid and Ladislav Valkovic and Elizabeth M Tunnicliffe and Christopher T Rodgers},
abstract={Inorganic Phosphate is a resonance that holds important information on the metabolic state of tissues. From its resonance frequency, intracellular pH can be derived. The ratio of P
i to PCr or ATP are also important markers. Unlike in other tissues, myocardial P
i is frequently hidden underneath blood 2,3-DPG signals. Using 7 T STEAM's T
M delay to be one cardiac cycle, blood-pool originating signals are gone and the Pi resonance is clearly visible. In 3 subjects, P
i signal was detected and quantified. The signal was around 4.89±0.02ppm, corresponding to a pH of 7.08±0.02. This is a breakthrough for the investigation of cardiac metabolism.}
}
@inproceedings{ISMRM2018_3991,
annote={ISMRM2018_3991},
pages={3991},
file={ISMRM2018_3991.pdf:ISMRM2018_3991.pdf:PDF},
title={First experiences with a phosphorus 30 channel receiver head array at 7T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3991.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Benjamin C Rowland and Ian Driver and Mohamed Tachrount and Dennis WJ Klomp and Ria Forner and Anh Pham and Michel Italiaander and Richard G Wise},
abstract={Multi-receiver arrays offer the high sensitivity of surface coils and the extended field of view of volume coils, as long as the individual receivers can be combined correctly. In 31P MRS, the low intrinsic SNR makes determining weighting factors challenging and data quality can suffer. We report on our experiences of working with a custom-built 30 channel head coil, dual-tuned for 1H and 31P at 7T, comparing its performance against a traditional birdcage, in phantom and in vivo. Our results are encouraging, with equal SNR in the centre of the brain and significantly enhanced signal in the periphery.}
}
@inproceedings{ISMRM2018_3992,
annote={ISMRM2018_3992},
pages={3992},
file={ISMRM2018_3992.pdf:ISMRM2018_3992.pdf:PDF},
title={In vivo Phosphorus Metabolite Imaging on a 3T {MRI} Scanner in a Clinically Feasible Scan Time},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3992.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yunhong Shu and Joshua D Trzasko and Aiming Lu and Joel P Felmlee and John D Port},
abstract={We developed an MRI system (coil, sequence, reconstruction) capable of performing imaging of phosphorus metabolites in a clinically-feasible scan time on a conventional 3T MRI scanner. Each component of the system is explained and results of a phantom scan and scan of a human thigh are presented.}
}
@inproceedings{ISMRM2018_3993,
annote={ISMRM2018_3993},
pages={3993},
file={ISMRM2018_3993.pdf:ISMRM2018_3993.pdf:PDF},
title={Functional phosphorus spectroscopy of the human visual cortex at 9.4 T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3993.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Rolf Pohmann and Sathiya Raju and Klaus Scheffler},
abstract={Functional
31P spectroscopy has been investigated in several studies with greatly varying results, which may be due to the low sensitivity of the
31P nucleus. We have taken advantage of the high SNR at 9.4 T to acquire spectra from the human visual cortex under stimulation. Experiments were performed with different localization volumes, defined by saturation pulses. In spite of the excellent quality of the obtained data, no stimulation-related changes in metabolite concentrations or resonance frequencies could be detected.}
}
@inproceedings{ISMRM2018_3994,
annote={ISMRM2018_3994},
pages={3994},
file={ISMRM2018_3994.pdf:ISMRM2018_3994.pdf:PDF},
title={T1 values of phosphorus metabolites in the human visual cortex at 9.4 T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3994.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Rolf Pohmann and Sathiya Raju and Klaus Scheffler},
abstract={Ultra-high field has the potential to improve the quality of
31P spectroscopic applications due to the increased SNR and spectral dispersion. In addition, previous studies have reported a decreasing T
1 with increasing field strength, which would further contribute to an improved quantification quality. In this study, we have measured the longitudinal relaxation time T
1 in the visual cortex of healthy human subjects at 9.4 T, using an inversion-recovery technique. The values obtained were consistently lower than published data at 7 T, confirming observations of a decreasing T
1 with field strength.}
}
@inproceedings{ISMRM2018_3995,
annote={ISMRM2018_3995},
pages={3995},
file={ISMRM2018_3995.pdf:ISMRM2018_3995.pdf:PDF},
title={Quantification of human cardiac inorganic phosphate content in vivo by
31P-{MRSI} at 7T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3995.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ladislav Valkovic and Albrecht I Schmid and Lucian AB Purvis and Jane Ellis and Matthew D Robson and Stefan Neubauer and Christopher T Rodgers},
abstract={Determination of human cardiac Pi using
31P-MRS is challenging as the resonance frequency of Pi is concealed by a close resonating 2,3-DPG signal originating from blood. Long TR acquisition using adiabatic excitation at 7T can compensate for the rapid blood signal replacement in partially-saturated short TR scans. In order to quantify Pi concentration in vivo, knowledge about longitudinal relaxation of Pi is still required. We have measured the T
1 of Pi in 4 healthy volunteers at 7T using dual-TR method and used this value to quantify cardiac Pi concentration in 8 healthy volunteers.}
}
@inproceedings{ISMRM2018_3996,
annote={ISMRM2018_3996},
pages={3996},
file={ISMRM2018_3996.pdf:ISMRM2018_3996.pdf:PDF},
title={In Vivo Measurement of Cerebral {NAD} Contends and Redox State in Young Mouse.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3996.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Radek Skupienski and Kim Q Do and Roger Marti and Lijing Xin},
abstract={Nicotimamide adenine dinucleotide (NAD
+ and NADH) is a key player of cell energy metabolism.
31P-MRS has been demonstrated for in vivo measurement of NAD content and redox state in cat and human brain, however, there is no reports in mouse brain. In this study we established the in vivo measurement of NAD
+, NADH and NAD
+/NADH in young (prepubetrtal) mice and compared two different quantification methods (Least square fitting and LCmodel). This study demonstrated the feasibility of in vivo measurement of NAD
+, NADH and redox state in mouse brain and it opens the prospect of studying longitudinally the energy metabolism and redox dysfunction in mouse models of brain pathologies.}
}
@inproceedings{ISMRM2018_3997,
annote={ISMRM2018_3997},
pages={3997},
file={ISMRM2018_3997.pdf:ISMRM2018_3997.pdf:PDF},
title={{SNR} optimized $^{31}$P f{MRS} to measure energy metabolism in the visual cortex},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3997.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Arjan D. Hendriks and Wybe J.M. van der Kemp and Natalia Petridou and Dennis W.J. Klomp},
abstract={Energy metabolism of the human visual cortex was investigated, by performing
31P fMRS. The used setup was optimized for high SNR by using a dedicated
31P RF coil at 7T and a visual stimulus with a large visual angle. Changes in the up-field peak of inorganic phosphate (Pi) are observed, revealing new promising opportunities to measure energy metabolism in the human visual cortex.}
}
@inproceedings{ISMRM2018_3998,
annote={ISMRM2018_3998},
pages={3998},
file={ISMRM2018_3998.pdf:ISMRM2018_3998.pdf:PDF},
title={Dietary modulation of metabolic enzyme activity assessed by dynamic in vivo 31P-{MRS} of hepatic fructose metabolism},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3998.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Christian T. Farrar and Gregory Tesz and Jeremy Wellen},
abstract={In this study,
31P-MRS was applied to monitor hepatic fructose metabolism of rats in response to IV fructose challenge. Animals exposed to 7-days of sucrose-enriched diet experienced enhanced fructose clearance relative to animals on an isocaloric control diet. The finding of more efficient fructose metabolism in the sucrose fed group corresponded with elevated KHK and AldoB gene expression, two key enzymes responsible for fructose clearance. Treatment of animals on sucrose diet with a KHK inhibitor nearly completely blocked fructose metabolism and prevented increased expression of these enzymes, implying that metabolism of fructose elicits the enzyme induction rather than fructose itself.}
}
@inproceedings{ISMRM2018_3999,
annote={ISMRM2018_3999},
pages={3999},
file={ISMRM2018_3999.pdf:ISMRM2018_3999.pdf:PDF},
title={In vivo $^{31}\hspace{0.1 mm}$P-{MRS} of triple negative breast cancer patients},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/3999.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Erwin Krikken and Wybe J.M. van der Kemp and Peter R. Luijten and Kenneth G.A. Gilhuijs and Dennis W.J. Klomp and Hanneke W.M. van Laarhoven and Jannie P. Wijnen},
abstract={
31P-MR spectra of breast cancer tissue have shown very high GPC/PC ratios in xenografts for triple negative (TN) tumors. We set out to investigate if this is also visible in vivo in six TN breast cancer patients. In two of the patients the phosphocholine (PC) peak is missing or approaching zero. To the best of our knowledge, this is the first time that this phenomenon is shown in vivo in breast cancer patients, however, the relation of the presence or absence of PC and TN subtype remains to be investigated.}
}
@inproceedings{ISMRM2018_4000,
annote={ISMRM2018_4000},
pages={4000},
file={ISMRM2018_4000.pdf:ISMRM2018_4000.pdf:PDF},
title={Detection of 13C glucose metabolism in multiple human brain regions using dynamic 1H {MRS}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4000.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Steven Zhang and Chathura Kumaragamage and Pedro Rosa Neto and Jamie Near},
abstract={In vivo carbon-13 magnetic resonance spectroscopy is a quantitative technique for studying brain metabolism. Here, we demonstrate the use of
1H MRS to indirectly observe the metabolism of
13C labelled glucose, simultaneously in two brain regions in a single healthy volunteer. This was done using only standard proton (
1H) MRS sequences and hardware. Our results demonstrate an accumulation of
13C label in glutamate and glutamine that is distinctly observable due to the pronounced effect of heteronuclear scalar coupling. This technique provides insight into neuronal metabolic rates and may provide complimentary information to
18F-FDG PET in the study of neurodegenerative disorders.}
}
@inproceedings{ISMRM2018_4001,
annote={ISMRM2018_4001},
pages={4001},
file={ISMRM2018_4001.pdf:ISMRM2018_4001.pdf:PDF},
title={Detection of 5-Fluorouracil (5-{FU}) Tumor Trapping Using Fluorine-19 Chemical Shift Imaging in a Murine Model of Colorectal Cancer},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4001.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yurii Shepelytskyi and Karen Davenport and Matthew S Fox and Tao Li and Mitchell Albert and Eric Davenport},
abstract={Colorectal cancer is an increasing healthcare problem and is the third leading cause of cancer deaths worldwide. Fluorine-19 (
19F) chemical shift imaging (CSI) can detect the distribution of 5-fluorouracil (5-FU) and its metabolites within a tumor over time. By measuring the 5-FU trapping, it is possible to determine the tumor response at the earliest stage of treatment (before changes in tumor size are observable). In this work, we present preliminary results of detecting the presence and absence of 5-FU trapping in mice bearing H-508 and HT-29 colorectal tumors, respectively.}
}
@inproceedings{ISMRM2018_4002,
annote={ISMRM2018_4002},
pages={4002},
file={ISMRM2018_4002.pdf:ISMRM2018_4002.pdf:PDF},
title={Mapping longitudinal changes in brain oxygenation in vascular cognitive impairment using 19F-{MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4002.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ahmed A Khalil and Susanne Mueller and Marco Foddis and Janet Lips and Ulrich Dirnagl and Sebastian Temme and Ulrich Floegel and Philipp Boehm-Sturm},
abstract={We assessed tissue oxygenation with 19F-MRI using perfluorocarbon emulsions in a mouse model of vascular cognitive impairment. Brain T1 values were measured using a cryogenic 19F/1H coil at multiple timepointsbefore and after surgery to induce bilateral common carotid artery stenosis and converted to pO
2. T1 values decreased with increasing concentration of inhaled oxygen and we observed a decrease in tissue pO
2 following surgery which gradually recovered over four weeks. 19F-MRI of perfluorocarbon emulsions can be used for long-term assessment of brain tissue pO
2 in vivo and may be relevant for monitoring endogenous or induced regenerative processes.}
}
@inproceedings{ISMRM2018_4003,
annote={ISMRM2018_4003},
pages={4003},
file={ISMRM2018_4003.pdf:ISMRM2018_4003.pdf:PDF},
title={3D 7Li Magnetic Resonance Imaging of Brain Lithium Distribution in Bipolar Disorder},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4003.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Fiona Elizabeth Smith and Peter Edward Thelwall and Carly Jay Flowers and Joe Necus and Andrew Matthew Blamire and David Andrew Cousins},
abstract={Lithium is a major treatment for bipolar disorder (BD) and the likelihood of a favourable response may be determined by its distribution in the brain. Lithium can be directly detected by magnetic resonance (MR), but this is challenging compared to proton MRI due to lithium’s low therapeutic concentration in brain (<1mM). To overcome this challenge, we implemented a highly efficient balanced steady state free precession (b-SSFP) 7Li-MRI method. We report a 3D 7Li-MRI acquisition with 25mm isotropic resolution, acquired in 8 minutes using a 3T clinical scanner, demonstrating heterogeneity in lithium concentration within the brain in subjects with BD (n=14).}
}
@inproceedings{ISMRM2018_4004,
annote={ISMRM2018_4004},
pages={4004},
file={ISMRM2018_4004.pdf:ISMRM2018_4004.pdf:PDF},
title={Use of dissolved-phase 129Xe imaging to visualize gas uptake and distribution in the free-breathing mouse},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4004.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Luis Loza and Stephen Kadlecek and Mehrdad Pourfathi and Kai Ruppert and Hooman Hamedani and Ian Duncan and Rahim R. Rizi},
abstract={The lung is an intrinsically difficult organ to image using conventional MRI. Although global structural features and major abnormalities are detectable using conventional MRI, lung structure on the vascular level is prohibitively difficult to image. Hyperpolarized gas MRI provides high enough signal to obtain high-resolution images of lung structure at the acinar level. Furthermore, with the use of hyperpolarized xenon MRI, dynamic images of xenon dissolution are made obtainable given xenon’s high solubility in blood and tissue. By applying decreasingly destructive pulses, the uptake and distribution of the gas throughout the body becomes visible.}
}
@inproceedings{ISMRM2018_4005,
annote={ISMRM2018_4005},
pages={4005},
file={ISMRM2018_4005.pdf:ISMRM2018_4005.pdf:PDF},
title={Effects of Fraction of Inhaled Oxygen on Hyperpolarized 129Xe {MR} Signals Acquired from the Rat Brain In Vivo},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4005.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yonni Friedlander and Marcus Couch and Andrea Kassner and Giles Santyr},
abstract={A theoretical model was developed to describe the dependence of the signal strength of
129Xe dissolved in the rat brain on the fraction of inhaled oxygen (F
iO
2). To validate the model,
129Xe MR signals were measured in the rat brain in vivo for four different values of F
iO
2 using a continuous ventilation scheme. The measured
129Xe RBC signal showed a strong dependence on F
iO
2 in good agreement with the trends predicted by the theoretical model. These results underscore the need to optimize and control F
iO
2 when using
129Xe signals to probe brain function.}
}
@inproceedings{ISMRM2018_4006,
annote={ISMRM2018_4006},
pages={4006},
file={ISMRM2018_4006.pdf:ISMRM2018_4006.pdf:PDF},
title={17O bolus fluxes in rat head at 21.1 T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4006.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Victor D. Schepkin and Cathy Levenson and Andreas Newbauer and Christian Schuch and Tilo Glaeser and Michael Kievel and Steven Ranner and William Brey and Shannon Helsper and Lothar Schad},
abstract={17O MRI is an attractive and promising goal utilizing ultra-high magnetic fields. The current study is devoted to the time changes of 17O MR signals detectable in a rat head at 21.1 T using bolus injection of 17O labeled water-17O and glucose-17O. The time course of 17O-water revealed a two stage process of distribution. During glucose injection the time course has the same stages as for water and the third stage represents glucose metabolism. The shape of the high resolution glucose time course is important for the accurate determination of tissue glucose consumption.
}
}
@inproceedings{ISMRM2018_4007,
annote={ISMRM2018_4007},
pages={4007},
file={ISMRM2018_4007.pdf:ISMRM2018_4007.pdf:PDF},
title={Metabolic Profiling of Blood Plasma for Distinguishing Prostate Cancer in Patients with Positive Biopsy and Negative Biopsy using {NMR} Spectroscopy},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4007.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Naranamangalam R Jagannathan and Pradeep Kumar and Rajeev Kumar and Virendra Kumar and Senthil S Kumaran and Sanjay Thulkar and Sanajy Sharma and Siddhartha D Gupta},
abstract={The metabolic profiling of blood plasma sample for distinguishing prostate cancer (PCa) patients with positive biopsy (n=32) and negative biopsy (n=30) using NMR spectroscopy was investigated. A significantly higher concentration of lactate, choline, glucose and a lower concentration of histidine, tyrosine and phenylalanine were observed in blood plasma of PCa patients with positive biopsy as compared to negative biopsy. Our results suggest alterations in amino acid, energy, glucose and choline metabolisms, which may have association with disease progression.}
}
@inproceedings{ISMRM2018_4008,
annote={ISMRM2018_4008},
pages={4008},
file={ISMRM2018_4008.pdf:ISMRM2018_4008.pdf:PDF},
title={Study of Altered Urinary Metabolism in Prostate Cancer Patients using {NMR} Metabolomics},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4008.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Pradeep Kumar and Rajeev Kumar and Virendra Kumar and Senthil S Kumaran and Sanjay Thulkar and Siddhartha D Gupta and Naranamangalam R Jagannathan},
abstract={The present study demonstrated the metabolic profile of urine samples of prostate cancer (PCa) patients (n=33) and healthy controls (HC; n=21) using 700 MHz high-resolution proton NMR for early diagnosis and to define noninvasive biomarker/s. A significantly lower concentration of leucine, histidine, tyrosine, citrate, dimethylglycine, glycerophosphocholine, choline, creatinine, indoxyl sulphate and formate was seen in PCa patients. These findings suggest metabolic alterations due to mitochondrial dysfunction, cell proliferation, energy demand, oxidative stress and protein turnover in PCa patients.}
}
@inproceedings{ISMRM2018_4009,
annote={ISMRM2018_4009},
pages={4009},
file={ISMRM2018_4009.pdf:ISMRM2018_4009.pdf:PDF},
title={Magnetic resonance spectroscopy-based metabolic biomarkers of {IDH}1 mutant glioma in response to temozolomide therapy},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4009.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Elavarasan Subramani and Lydia M Le Page and Russell O. Pieper and Sabrina M Ronen},
abstract={The alkylating agent temozolomide (TMZ), previously used only in the treatment of high-grade glioblastoma, is now being considered for the treatment of low-grade glioma that are driven by mutations in the cytosolic isocitrate dehydrogenase 1 (IDH1) gene. However, early detection of response remains a challenge.
1H magnetic resonance spectroscopy-based metabolic profiling of cells genetically engineered to express mutant IDH1 and treated with TMZ showed significant alterations in metabolites majorly related to the tricarboxylic acid cycle, pyruvate metabolism and the pentose phosphate pathway. These findings hold potential for assessing response of IDH1 mutant cells to TMZ therapy.}
}
@inproceedings{ISMRM2018_4010,
annote={ISMRM2018_4010},
pages={4010},
file={ISMRM2018_4010.pdf:ISMRM2018_4010.pdf:PDF},
title={In vitro screening of drug response in {HIV}-1 pseudovirus infected cells using {NMR}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4010.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Aruna Singh and Muzamil Makhdoomi and Kalpana Luthra and Thirumurthy Velpandian and Rama Jayasundar},
abstract={There is a necessity for novel and quick drug response screening methods for providing lead information for drug discovery. In this context, NMR can be a potential screening method. This study has used proton NMR spectroscopy for drug response in HIV-1 psuedovirus infected TZM-bl cells after treatment with TAK 779 (positive control) and benzene extracts of Terminalia bellerica and Zingiber officinale. Significant reduction in metabolites was observed in infected cells and metabolites were subsequently restored closer to normal levels on treatment with positive control and plant extracts. The study has demonstrated NMR to be a quick screening method for drug response.}
}
@inproceedings{ISMRM2018_4011,
annote={ISMRM2018_4011},
pages={4011},
file={ISMRM2018_4011.pdf:ISMRM2018_4011.pdf:PDF},
title={Comparative {NMR} urine metabolomics of whole body or partial body radiation exposure: Stepping towards delivery of potent marker for radiation exposure},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4011.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Poonam Rana and Ajaswrata Dutta and Sushant K Mishra and Kiran Maan and Manju Lata Gupta and Subash Khushu},
abstract={Stepping forward towards the quest of high throughput radiation marker, the present study looks for a common signature on comparison of NMR based urine metabolomics post whole body or partial irradiation. Different group of animals were exposed to 10 Gy whole body or partial radiation. Irradiated group were clustered apart from controls; showed similar pattern on radiation exposure irrespective of whole body or cranial and identified taurine, citrate as common metabolites in whole body and partial radiation groups. The similar pattern observed post partial or whole body irradiation further confirm these metabolites as potent markers for radiation exposure.}
}
@inproceedings{ISMRM2018_4012,
annote={ISMRM2018_4012},
pages={4012},
file={ISMRM2018_4012.pdf:ISMRM2018_4012.pdf:PDF},
title={{NMR} based Metabonomics study of Chronic Cold Stress induced metabolic alterations in rat model},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4012.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={SONIA GANDHI and SUBASH KHUSHU},
abstract={Primary hypothermia/cold stress is due to environmental exposure, with no underlying medical condition causing disruption of temperature regulation. The exposure of human to such conditions often leads to decremented physical and mental performance. Metabonomics can provide a quick snapshot of exogenous/endogenous stressors induced metabolic perturbations. The metabolic pathways analysis showed that Taurine and TCA metabolism have maximum contribution to the altered urine metabolic phenotype. Metabolic markers related to liver dysfunction, gut microflora \& muscle bioenergetics were altered due to cold exposure. These changes in combination with genomics and proteomics studies would further reveal potential drug targets contributing to cold exposure medicine.}
}
@inproceedings{ISMRM2018_4013,
annote={ISMRM2018_4013},
pages={4013},
file={ISMRM2018_4013.pdf:ISMRM2018_4013.pdf:PDF},
title={{NMR}-{BASED} {METABOLOMIC} {ANALYSIS} {AS} A {DIAGNOSTIC} {TOOL} {FOR} {TUBERCULOSIS} {IN} {CLINICAL} {URINE} {SAMPLES}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4013.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jose Luis Izquierdo-Garcia and Ramon Campos-Olivas and Mar Serra and Cristina Prat and Jose Dominguez and Jesus Ruiz-Cabello},
abstract={The ability of diagnose the tuberculosis infection is an essential factor in the spreading control of tuberculosis. However, microscopic examination presents a low sensitivity and culture techinques require incubation times up to two months. This study aimed at developing a NMR-based metabolomic approach for the differential diagnosis of tuberculosis in urine samples. We examined samples from patients diagnosed of tuberculosis (n=19), other respiratory infection (n=25) and healthy controls (n=29). Unsupervised PCA provide a nearly perfect discrimination between the three groups. We identified 31 chemical shifts regions to develop predictive models for the diagnostic of tuberculosis, obteining an accuracy of 100\%.}
}
@inproceedings{ISMRM2018_4014,
annote={ISMRM2018_4014},
pages={4014},
file={ISMRM2018_4014.pdf:ISMRM2018_4014.pdf:PDF},
title={Targeted and untargeted {NMR} phytometabolomics for polar chemosensory markers and signatures},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4014.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Aruna Singh and Dushyant Kumar and Rama Jayasundar},
abstract={The potential of proton NMR metabolomics to classify medicinal and nutraceutical plants based on their chemosensory property such as taste has been explored in this study. Polar fractions obtained by dual phase (chloroform-methanol/water) extraction of select plants (n=48) from four chemosensory groups were studied using water suppressed 1D proton NMR spectroscopy. Untargeted metabolomics showed distinct chemosensory based clustering using Partial Least Square Discriminant Analysis. Using targeted metabolomics, chemosensory phytomarkers like α- and β- glucose (sweet), swertiamarin (bitter), trigonelline (pungent) and quercetin (astringent) were identified. The study has shown that NMR can play an important role in sensory science.}
}
@inproceedings{ISMRM2018_4015,
annote={ISMRM2018_4015},
pages={4015},
file={ISMRM2018_4015.pdf:ISMRM2018_4015.pdf:PDF},
title={Determination of the metabolome of Giardia lamblia by 1H Magic Angle Spinning {NMR}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4015.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Martina Vermathen and Joachim Müller and Norbert Müller and Peter Vermathen},
abstract={The intestinal protozoan parasite Giardia lamblia is a major cause of persistent diarrhea in humans and animals worldwide. Details concerning underlying metabolic pathways in Giardia are scarce and a methodology to study giardial intermediary and energy metabolism is required. Here, a high resolution magic angle spinning (HR-MAS) NMR study is presented determining the metabolic profile of G. lamblia trophozoites. This study builds the basis of following investigations on Giardia that are resistant against Metronidazole and other nitro compounds, which have been used since decades as therapy of choice against giardiasis.}
}
@inproceedings{ISMRM2018_4016,
annote={ISMRM2018_4016},
pages={4016},
file={ISMRM2018_4016.pdf:ISMRM2018_4016.pdf:PDF},
title={Removal of Water Sidebands from
1H-{MRSI} Data Acquired without Water Suppression},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4016.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yudu Li and Fan Lam and Rong Guo and Bryan Clifford and Xi Peng and Zhi-Pei Liang},
abstract={The water sideband artifact is a major obstacle to proton MR spectroscopic imaging (
1H-MRSI) without water suppression (WS). This work presents a novel method to remove the sideband artifacts from non-WS MRSI data, characterized by the use of a reference-based parametric model to represent the artifacts. Our method obtains the reference signal from two auxiliary scans and subsequently estimates the sideband signals from a particular MRSI data. The proposed method has been validated using both phantom and in vivo experimental data, demonstrating that it can effectively remove the sideband artifacts without introducing spectral distortion. This method is expected to be useful for many non-WS MRSI studies.}
}
@inproceedings{ISMRM2018_4017,
annote={ISMRM2018_4017},
pages={4017},
file={ISMRM2018_4017.pdf:ISMRM2018_4017.pdf:PDF},
title={Oxidative Stress and Neurotransmitters Imbalance in Amyotrophic Lateral Sclerosis},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4017.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Mona Adel Mohamed and Muhammad Saleh and Mark Mikkelsen and Kristen Riley and Jeffrey Rothstein and Lora Clawson and Peter B Barker and Richard AE Edden},
abstract={Amyotrophic lateral sclerosis (ALS) is a rapidly progressive and invariably fatal motor neuron disease. The objective of the study was to use the newly developed HERMES (Hadamard Encoding and Reconstruction of MEGA-Edited Spectroscopy) spectral editing methodology to simultaneously measure key compounds related to oxidative stress and glutamatergic metabolism (GSH, GABA and Glx) in patients with ALS and control subjects. Using HERMES, we were able to look at different metabolic pathways in ALS in one MRS session. Improved understanding of the various metabolic pathways in ALS will lead to the development of new diagnostic surrogate markers and therapeutic approaches.}
}
@inproceedings{ISMRM2018_4018,
annote={ISMRM2018_4018},
pages={4018},
file={ISMRM2018_4018.pdf:ISMRM2018_4018.pdf:PDF},
title={The effect of a 12-week aerobic exercise intervention on neurometabolites in young healthy adults using 7T 1H-{MRS}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4018.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Anouk Schrantee and Jannie Wijnen and Michelle M Solleveld and Aart J Nederveen and Serge Dumoulin and Dennis WJ Klomp and Liesbeth Reneman and Paul J Lucassen},
abstract={Prolonged exercise has beneficial effects on cognition, which could be mediated by changes in neuronal metabolism. We present the first 7T MRS exercise study investigating neurometabolite concentrations before and after randomization to aerobic exercise or toning exercise in a large sample of healthy volunteers. We found that change in cardiovascular fitness was positively associated with changes in hippocampus glutamine and negatively associated with change in glutamate in the anterior cingulate cortex; regardless of exercise group. This suggests that exercise-induced metabolic changes might not specific to the hippocampus and that exercise likely has widespread effects on brain metabolism.}
}
@inproceedings{ISMRM2018_4019,
annote={ISMRM2018_4019},
pages={4019},
file={ISMRM2018_4019.pdf:ISMRM2018_4019.pdf:PDF},
title={Effect of lactate administration on brain lactate concentrations during hypoglycemia in patients with type 1 diabetes},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4019.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Evita Wiegers and Hanne Rooijackers and Cees Tack and Bart Philips and Arend Heerschap and Bastiaan de Galan and Marinette van der Graaf},
abstract={Lactate administration during hypoglycemia suppresses counterregulatory responses, which mimicks the condition of impaired awareness of hypoglycemia (IAH) seen in patients with type 1 diabetes. Lactate can act as an alternative cerebral fuel and/or lactate can drive other brain-protective processes. We examined whether lactate administration affects brain lactate concentrations, as measured with J-difference editing
1H-MRS, during hypoglycemia in patients with normal awareness of hypoglycemia (NAH) and in patients with IAH. Brain lactate concentrations increased modestly upon lactate infusion in both groups. These results suggest that the excess lactate entering the brain is immediately oxidized, which may suppress the hypoglycemic counterregulatory response.}
}
@inproceedings{ISMRM2018_4020,
annote={ISMRM2018_4020},
pages={4020},
file={ISMRM2018_4020.pdf:ISMRM2018_4020.pdf:PDF},
title={Neurofunctional deficits and cellular metabolic changes associated with working memory dysfunction in patients with generalized anxiety disorder},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4020.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Chung-Man Moon and Gwang-Woo Jeong},
abstract={Generalized anxiety disorder (GAD) negatively affects emotional regulation and cognitive function. However, the causality between neurofunctional and metabolic brain alterations is not clearly revealed since the brain function and metabolic studies have been independently performed. A combined fMRI and
1H-MRS study would be necessary to investigate whether both of the brain functional abnormality and the metabolic changes are associated with the emotional dysregulation and cognitive deficit in GAD. Therefore, the purpose of this study was to assess the association between neurofunctional deficits and cellular metabolic changes under working memory (WM) tasks in patients with GAD.}
}
@inproceedings{ISMRM2018_4021,
annote={ISMRM2018_4021},
pages={4021},
file={ISMRM2018_4021.pdf:ISMRM2018_4021.pdf:PDF},
title={Signal Enhancement Under Explicit Field Perturbation in Magnetic Resonance Spectroscopy},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4021.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Dhiraj Sinha and Smitha Thamarath Surendran},
abstract={The current work presents a novel approach on signal enhancement in magnetic resonance spectroscopy through explicit field perturbatiobn. We have discovered that under certain conditions of artificial perturbation of the existing field, the output signal can be enhanced. The signal enhancement not only happens by increasing the magnitude of the external signal at the precession frequency but also by changing the frequency of the external field. The results have broad application not only in the field of magnetic resonance spectroscopy but also in magnetic resonance imaging.}
}
@inproceedings{ISMRM2018_4022,
annote={ISMRM2018_4022},
pages={4022},
file={ISMRM2018_4022.pdf:ISMRM2018_4022.pdf:PDF},
title={Use of Ab-Initio Molecular Dynamics Simulations to Estimate Hyperpolarized 13C Agent Spin-Lattice Relaxation Times},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4022.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Joe Wildenberg and Stephen Kadlecek and Rahim R. Rizi and Terence Gade},
abstract={We demonstrated the feasibility of using an ab-initio molecular dynamics simulation to estimate the T
1 relaxation time constant of hyperpolarized
13C substrates. The utility of such predictive tools would provide further insight into specific relaxation mechanisms involved in various substrates, allowing us to evaluate candidate strategies to extend their T
1 relaxation time constants. Such screening of candidate hyperpolarized agents may be used to rapidly assess polarizability of agents specific to various molecular pathways.}
}
@inproceedings{ISMRM2018_4023,
annote={ISMRM2018_4023},
pages={4023},
file={ISMRM2018_4023.pdf:ISMRM2018_4023.pdf:PDF},
title={A metabolomic evaluation of prostate cancer field effects},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4023.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Sarah S. Dinges and Lindsey A. Vandergrift and Shulin Wu and Yannick Berker and Chin-Lee Wu and Piet Habbel and Leo L. Cheng},
abstract={The gold standard in diagnosing prostate cancer (PCa) is pathological examination of biopsy cores. Still, false negative rates remain between 30-50\%. Studies of cancer field effects suggest that tissue without histologically visualizable cancer cells has diagnostic value and could enlarge biopsy target regions. To map metabolic field effects in human prostates, we used HRMAS-MRS to analyze multiple tissue samples throughout entire removed cancer-positive prostates. Evaluation of metabolomic profiles of histologically-benign (Hb) tissue showed that Hb tissues at varying distances to PCa lesions have different metabolic profiles. Hb tissue enables differentiation between clinical parameters (Gleason Score, pathological stage, cancer-affected prostate \%).}
}
@inproceedings{ISMRM2018_4024,
annote={ISMRM2018_4024},
pages={4024},
file={ISMRM2018_4024.pdf:ISMRM2018_4024.pdf:PDF},
title={In vitro {NMR} spectroscopy identifies metabolic changes resulting from addition of a novel anti-cancer agent ({AZD}2014) to standard treatment, guiding potential imaging approaches},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4024.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Nada Al-Saffar and Jasmin Sidhu and Udai Banerji and Yuen-Li Chung and Martin O. Leach},
abstract={Previous reports showed that activation of the PI3K/mTOR pathway is associated with chemoresistance in ovarian cancer cells and this can be reversed by combining chemotherapy with the mTORC1/2 inhibitor vistusertib (AZD2014). This combination is now being pursued clinically. In this study, we used NMR spectroscopy to establish biomarkers for this combination in A2780Cis human ovarian carcinoma cells. We report that this combination resulted in decreases in lactate, PC, GPC and tCho and was associated with inhibition of glycolysis- and choline-regulatory enzymes. This indicates that choline metabolites and lactate may provide potential non-invasive biomarkers of tumour response to this combination therapy.}
}
@inproceedings{ISMRM2018_4025,
annote={ISMRM2018_4025},
pages={4025},
file={ISMRM2018_4025.pdf:ISMRM2018_4025.pdf:PDF},
title={Exploring Glutamate and Glutamine Metabolism Across Breast Cancer Subtypes using High-resolution Proton {MRS} Combined with Molecular Approaches},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4025.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Caitlin M Tressler and Vinay Ayyappan and Kristine Glunde},
abstract={We have studied glutamine metabolism in a panel of breast cancer cell types to examine the utilization of glutamine as an energy source in different subtypes of breast cancer. We utilized high-resolution 1H MRS detection of glutamine and glutamate from cell extracts to determine up regulation of glutamine metabolism as a whole followed by quantitative RT-PCR to begin to establish the critical pathways involved in altered glutamine metabolism within malignant cell types. Altered glutamine metabolite signatures may be used to identify malignancy within cells and key enzymes in glutamine metabolism may prove to be potential therapeutic targets.}
}
@inproceedings{ISMRM2018_4026,
annote={ISMRM2018_4026},
pages={4026},
file={ISMRM2018_4026.pdf:ISMRM2018_4026.pdf:PDF},
title={{MRS}-based metabolomic approaches detect multiple metabolic targets for the antitumor action of metformin on U87{MG} glioma cells.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4026.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Marco Rinaudo and Agnese Sacchetti and Serena Cecchetti and Laura Mercurio and Maria Jose Caramujo and Mattea Chirico and Marika Pinazza and Giulia Carpinelli and Stefano Indraccolo and Franca Podo and Egidio Iorio},
abstract={There is an urgent need to develop novel therapeutic strategies for malignant brain tumors. Purposes of this study were: 1) to investigate in glioma cells the alterations induced by metformin in the levels of metabolites produced by different biochemical pathways ( glycolysis and phosphatidylcholine (PC) metabolism); 2) to evaluate the possibility to enhance the antiproliferative effects of metformin by a combination of metformin with a selected inhibitor of PC metabolism. We found : a) activation of PC-plc and PCho accumulation in metformin-treated cells; b) enhanced cell death in glioma cells with a combination of metformin and the PC-plc.}
}
@inproceedings{ISMRM2018_4027,
annote={ISMRM2018_4027},
pages={4027},
file={ISMRM2018_4027.pdf:ISMRM2018_4027.pdf:PDF},
title={Probehead design for multi-photon {NMR} induced homonuclear continuous {RF} decoupling},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4027.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Christoph Michael Schildknecht and David Otto Brunner and Klaas Paul Pruessmann},
abstract={Spectra of strongly coupled nuclear systems are frequently obtained by fast magic angle spinning. In biological samples, this is often not feasible, leaving homonuclear RF decoupling as the only alternative. This approach requires fast nutation while receiving a spectrum from the same type of nuclei. This can be achieved by multi-photon excitation, albeit at the expense of high power densities. In this work, we present a construction approach for such probe heads maximizing the excitation efficiency and demonstrating nutations above 20kHz over extended periods of time.}
}
@inproceedings{ISMRM2018_4028,
annote={ISMRM2018_4028},
pages={4028},
file={ISMRM2018_4028.pdf:ISMRM2018_4028.pdf:PDF},
title={Investigation of bioenergetic adaptations under galactose stress in {OXPHOS} deficient fibroblasts using a combined metabolic Flux and {HR}-{MAS} {NMR} approach},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4028.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Damian Hertig and Andrea Debora Felser and Gaëlle Diserens and Sandra Kurth and Peter Vermathen and Jean-Marc Nuoffer},
abstract={Defects in the mitochondrial OXPHOS lead to an extremely heterogeneous group of disorders and common laboratory screening methods are prone to misinterpretations. In this study we report metabolic adaptation of OXPHOS deficient human skin fibroblasts during galactose stress condition. We report a rapid HR-MAS NMR based method for the relative quantification of untargeted metabolome profiling providing containment of over 40 metabolites, which allowed us to observe unique cellular metabolic profiles in OXPHOS deficient fibroblast.}
}
@inproceedings{ISMRM2018_4029,
annote={ISMRM2018_4029},
pages={4029},
file={ISMRM2018_4029.pdf:ISMRM2018_4029.pdf:PDF},
title={Betaine detection in human brain},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4029.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Stefan Bluml and Jessica L Wisnowski and Marvin D Nelson and Tai-Wei Wu},
abstract={Betaine, an essential osmolyte and source of methyl groups, is a metabolite known to be present in brain. However, due to its low concentrations and its overlap with the choline signal, betaine detection and quantitation is difficulty. In this study, we quantified betaine in high-quality spectra of pediatric patients and controls. The measured betaine concentrations of 0.1 - 0.2 mM are consistent with what has been measured in rat brain extracts by high-field NMR.}
}
@inproceedings{ISMRM2018_4030,
annote={ISMRM2018_4030},
pages={4030},
file={ISMRM2018_4030.pdf:ISMRM2018_4030.pdf:PDF},
title={High resolution localized 2D {JPRESS} spectroscopy with absorption-mode lineshape},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4030.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Lin Yanqin and Dan Tian and Bo Duan and Qing Zeng and Zhong Chen},
abstract={Localized two-dimensional J-resolved spectroscopy (JPRESS) has been employed in the study of a number of diseases. However, phase-twisted lineshape and broad dispersion tails of magnitude peaks limit its usefulness. Here, a method based on the combination of JPRESS and anti-JPRESS alike spectra is proposed to remove the dispersive parts of the phase-twisted and to give absorption-mode JPRESS spectroscopy. This can double the resolution of JPRESS spectra at the cost of greatly reduced sensitivity. The method was performed with a phantom on a 7T animal scanner.
}
}
@inproceedings{ISMRM2018_4031,
annote={ISMRM2018_4031},
pages={4031},
file={ISMRM2018_4031.pdf:ISMRM2018_4031.pdf:PDF},
title={Fast {MRI} by Exploiting a Reference Scan ({FASTMER}) for {MR} Thermometry},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4031.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Efrat Shimron and Haim Azhari},
abstract={
A Compressed Sensing approach for shortening acquisition time in Magnetic Resonance guided Focused Ultrasound (MRgFUS) thermometry is presented. The approach is based on the recently developed Fast MRI by Exploiting a Reference scan (FASTMER) method. The suggested method embeds into the CS optimization problem a regularization term related to a-priori knowledge about the similarity between pre-heating and post-heating acquired data. The results obtained from an in-vitro Focused Ultrasound (FUS) experiment demonstrate that the proposed method provides efficient and accurate temperature mapping from substantially subsampled k-space data. The method is suitable for data acquired with flexible undersampling schemes.}
}
@inproceedings{ISMRM2018_4032,
annote={ISMRM2018_4032},
pages={4032},
file={ISMRM2018_4032.pdf:ISMRM2018_4032.pdf:PDF},
title={Combining Compressed Sensing and Parallel Imaging for Accelerating Focused Ultrasound {MR} Thermometry},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4032.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Efrat Shimron and Haim Azhari},
abstract={A novel method for accelerated multi-coil Magnetic Resonance guided High Intensity Focused Ultrasound (MRgHIFU) thermometry is presented. This method integrates the two powerful approaches of parallel imaging and Compressed Sensing (CS) and reconstructs temperature rise from sub-sampled k-space data. The proposed reconstruction process utilizes the sparsity of the differences between baseline and post-heating data and operates in a calibrationless manner. The method was validated through a retrospective study of data from a 8-coils in-vivo human prostate treatment and a 2-coils animal experiment.}
}
@inproceedings{ISMRM2018_4033,
annote={ISMRM2018_4033},
pages={4033},
file={ISMRM2018_4033.pdf:ISMRM2018_4033.pdf:PDF},
title={In vivo feasibility of {PRF} thermometry in the swine pancreas during laser ablation},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4033.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Céline Giraudeau and Paola Saccomandi and Federico Davrieux and Giuseppe Quero and Emiliano Schena and Michele Diana and Francesco Maria Di Matteo and Guido Costamagna and Jacques Marescaux},
abstract={The purpose of this preliminary work was to investigate the feasibility to get accurate PRF thermometryimages in the in vivo swine pancreas during laser ablation. We show that PRF thermometry images and consistent temperatures curves can be obtained during the procedure and these results are confirmed by temperature sensor measurements and histological examination. The presence of a susceptibility artifact (presence of gas bubbles) is discussed.}
}
@inproceedings{ISMRM2018_4034,
annote={ISMRM2018_4034},
pages={4034},
file={ISMRM2018_4034.pdf:ISMRM2018_4034.pdf:PDF},
title={Three-dimensional assessment of {MRI}-guided percutaneous liver ablation},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4034.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Elena Kaye and Kathleen Jedruszczuk and Jeremy Durack and Majid Maybody and Stephen Solomon},
abstract={Here we present a 3D registration-based technique for assessment of ablative margins following MRI-guided thermal ablation. The method was developed and evaluated in a retrospective study of 26 MRI-guided cryo, laser or microwave ablations of various liver metastases.}
}
@inproceedings{ISMRM2018_4035,
annote={ISMRM2018_4035},
pages={4035},
file={ISMRM2018_4035.pdf:ISMRM2018_4035.pdf:PDF},
title={Improved {MR} thermometry during Microwave ablation by correcting for sporadic electromagnetic interference},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4035.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Aiming Lu and Krzysztof R Gorny and Christopher P Favazza and Joel P Felmlee and David A Woodrum},
abstract={Image-guided microwave ablation (MWA) is a minimally invasive treatment for localized diseases. MRI is advantageous for localizing the lesions, guiding microwave antennae placement and assessing the extent of ablation. Monitoring of MWA in real-time using MR thermometry has also been demonstrated to be feasible, but can suffer from the image quality degradation due to electromagnetic interference (EMI) from the microwave generator (MWG). A novel approach to correct for EMI-contaminated images is presented here by utilizing the uncontaminated k-space data from neighboring frames. Significantly improved temperature and thermal dose maps have been obtained in our clinical patient studies.}
}
@inproceedings{ISMRM2018_4036,
annote={ISMRM2018_4036},
pages={4036},
file={ISMRM2018_4036.pdf:ISMRM2018_4036.pdf:PDF},
title={Measurement of Focal Laser Ablation Zones in Prostate Cancer using High Resolution Spectroscopic Imaging of the Water Resonance},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4036.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Shiyang Wang and Xiaobing Fan and Ambereen Yousuf and Scott Eggener and Gregory Karczmar and Aytekin Oto},
abstract={MRI-guided Focal laser ablation (FLA) is used to treat prostate cancer. Contrast enhanced imaging can assess the ablated region, but cannot be used during ablation due to effects of high energy ultrasound on MRI contrast agent stability. Our results show that high resolution MR spectroscopic imaging of the water resonance detects changes in T2* and water resonance peak amplitude that clearly delineate the ablation zone without contrast agent injection. Ablation zones measured by MR spectroscopic imaging are consistent with contrast enhanced images. This suggests that MR spectroscopic imaging can guide FLA during ablation to dynamically optimize treatment and improve outcomes.}
}
@inproceedings{ISMRM2018_4037,
annote={ISMRM2018_4037},
pages={4037},
file={ISMRM2018_4037.pdf:ISMRM2018_4037.pdf:PDF},
title={Ultrafast Temperature Estimation from Undersampled K-Space for {MR} Guided Microwave Ablation},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4037.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ke Wang and Zijing Dong and Fuyixue Wang and Bingyao Chen and Jiafei Yang and Xing Wei and Kui Ying},
abstract={Improved fast k-space temperature estimation using Golden Angle (GA) radial can effectively accelerate the computation process and reduce the motion artifacts. However, existing MR temperature imaging methods are time-consuming and the limited performance prevent their clinical applications. This work proposed a ultrafast method to largely accelerate temperature estimation process. Using a continuous fast k-space temperature estimation, together with improved algorithm design, GPU acceleration and more efficient computation, we achieve temperature estimation with 2 seconds temporal resolution.}
}
@inproceedings{ISMRM2018_4038,
annote={ISMRM2018_4038},
pages={4038},
file={ISMRM2018_4038.pdf:ISMRM2018_4038.pdf:PDF},
title={Bloch simulation-based correction for 2D {VFA} T1 mapping for fat {MR} thermometry},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4038.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ieva Braskute and Roel Deckers and Max A Viergever and Chrit TW Moonen and Lambertus W Bartels},
abstract={For MR-HIFU thermal therapies, specifically in the breast, MR temperature mapping both in aqueous and fatty tissues is desired, as it would improve treatment monitoring compared to MR thermometry in aqueous tissues only. Fat thermometry based on T1-mapping with 2D variable flip angle method offers high temporal resolution; however, 2D T1 mapping suffers from systematic errors caused by non-rectangular 2D slice profile. We propose a Bloch simulation-based 2D T1 correction technique to improve the accuracy of 2D T1 measurements. We demonstrate the proposed correction on simulated and experimental data.}
}
@inproceedings{ISMRM2018_4039,
annote={ISMRM2018_4039},
pages={4039},
file={ISMRM2018_4039.pdf:ISMRM2018_4039.pdf:PDF},
title={Early clinical feasibility study of body mounted and motorized needle guidance tool in abdominal {MRI}-guided cryoablation},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4039.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Nobuhiko Hata and Brian Ninni and Franklin King and Takahisa Kato and Junichi Tokuda and Kemal Tuncali},
abstract={This study investigates the feasibility of directing cryotherapy probes using a body-mounted and motorized needle guidance device in abdominal MRI-guided cryoablation. Utilizing a motorized needle alignment device offers an alternative solution to the trial-and-error method of probe placement, as it allows one to directly orient cryotherapy probes, efficiently. This study found the method to be feasible for use in cryoablation in 3T with placement accuracy of 8.8mm. Further investigation is warranted to improve the efficiency of probe placement.}
}
@inproceedings{ISMRM2018_4040,
annote={ISMRM2018_4040},
pages={4040},
file={ISMRM2018_4040.pdf:ISMRM2018_4040.pdf:PDF},
title={Design of Focused Radio Frequency Heating Array Coils for Non-Invasive Hyperthermia with Ultra-High Field {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4040.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Joshua de Bever and Mihir Pendse and Brian K Rutt},
abstract={This abstract details the implementation of an automated pipeline for designing high channel count RF coils for the purpose of non-invasive Focused RF hyperthermia generated from Ultra-high field MRI parallel transmit coils. The pipeline integrates multiple tools including Sim4Life for EM-FDTD simulations in the Virtual Population physiologically realistic body models, Advanced Design Systems circuit simulator and Matlab for custom algorithm execution. This work leverages GPU acceleration which has reduced simulation times for an 84 channel RF coil from 77 days on a CPU to 6 hours on three compute nodes equipped with 14 affordable GPUs.}
}
@inproceedings{ISMRM2018_4041,
annote={ISMRM2018_4041},
pages={4041},
file={ISMRM2018_4041.pdf:ISMRM2018_4041.pdf:PDF},
title={The effect of k-space weighted image contrast ({KWIC}) and ultrasound focus size on the accuracy of proton resonance frequency ({PRF}) thermometry},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4041.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Bryant T. Svedin and Christopher R. Dillon and Dennis L. Parker},
abstract={Stack of stars acquisitions with k-space weighted image contrast (KWIC) reconstruction provide an effectively high temporal resolution with high spatial resolution. The effective temporal resolution of KWIC reconstructions depend on the size of the object of interest. This abstract investigates the relationship between ultrasound focus size, the size of the KWIC window and the accuracy/precision of PRF temperature measurements.}
}
@inproceedings{ISMRM2018_4042,
annote={ISMRM2018_4042},
pages={4042},
file={ISMRM2018_4042.pdf:ISMRM2018_4042.pdf:PDF},
title={Blood-brain barrier disruption and delivery of irinotecan in a rat model using a clinical transcranial {MRI}-guided focused ultrasound system},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4042.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Nathan McDannold and Yongzhi Zhang and Chanikarn Power and Natalia Vykhodtseva},
abstract={The feasibility of controlled blood-brain barrier (BBB) disruption in rats was demonstrated with a low-frequency clinical transcranial MRI-guided focused ultrasound device that operates at 230 kHz (ExAblate Neuro, InSightec) combined with microbubbles. Thirty-six targets were sonicated in one hemisphere in each experiment under closed-loop control based on real-time recordings of acoustic emissions. Disruption was confirmed in maps of R1 relaxation following Gadavist administration. After three weekly BBB disruptions covering an entire hemisphere, we always produced BBB disruption with only minor vascular side effects. We also delivered irinotecan chemotherapy across the BBB without apparent neurotoxicity.}
}
@inproceedings{ISMRM2018_4043,
annote={ISMRM2018_4043},
pages={4043},
file={ISMRM2018_4043.pdf:ISMRM2018_4043.pdf:PDF},
title={Synergistic effect of {MR}-{HIFU} hyperthermia mediated drug delivery followed by ablation},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4043.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Edwin Heijman and Nicole Hijnen and Esther Kneepkens and Mariska de Smet and Sander Langereis and Holger Grüll},
abstract={Four Magnetic Resonance-guided High Intensity Focused Ultrasound (MR-HIFU) thermal therapy strategies (no HIFU, hyperthermia, ablation and hyperthermia followed by ablation) in combination with temperature sensitive liposomes (TSLs), co-encapsulating doxorubicin (dox) and ProHance®, were investigated in rhabdomyosarcoma rat tumor model. All HIFU heating strategies combined with TSLs resulted in cellular uptake of dox deep into the interstitial space and significant increase of intratumoral drug concentrations. The combination of hyperthermia-triggered TSLs followed by ablation showed the best therapeutic outcome compared to other strategies due to direct induction of thermal necrosis in the tumor core and efficient drug delivery to the tumor rim.}
}
@inproceedings{ISMRM2018_4044,
annote={ISMRM2018_4044},
pages={4044},
file={ISMRM2018_4044.pdf:ISMRM2018_4044.pdf:PDF},
title={Shear wave elastography using multi-point acoustic radiation force imaging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4044.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Lorne W. Hofstetter and Henrik Odéen and Bradley D. Bolster, Jr. and Douglas A. Christensen and Allison Payne and Dennis L. Parker},
abstract={Characterizing the mechanical properties of tissue during focused ultrasound ablative therapies could provide useful information for pretreatment planning and treatment endpoint assessment. In this work we present a 3D MR acquisition capable of measuring propagating shear waves from a spatially distributed collection of focused ultrasound generated acoustic radiation force impulses. This new multi-point shear wave elastography technique is demonstrated and compared to conventional MR elastography.}
}
@inproceedings{ISMRM2018_4045,
annote={ISMRM2018_4045},
pages={4045},
file={ISMRM2018_4045.pdf:ISMRM2018_4045.pdf:PDF},
title={Longitudinal multi-parametric {MRI} follow-up of ultrasound induced blood-brain barrier disruption in rats},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4045.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Allegra Conti and Françoise Geffroy and Hermes Kamimura and Fawzi Boumezbeur and Sébastien Mériaux and Benoit Larrat},
abstract={Focused Ultrasound in conjunction with microbubbles allows the reversible and safe opening of the BBB in a narrow range of Acoustic Pressure (AP). Here we wanted to investigate what happens to the brain tissues at short- and long-terms in case of an excessive AP is reached in vivo. Passive Cavitation Detection has been used to register inertial cavitation during the opening. At 1,3,7,14 and 28 days after the BBB opening, T
1,2-weighted images, T
2*-maps, DWI, MRS acquisitions and histological analysis have been performed. P-gp and myelin expression, cells deaths and astrocytes/microglial activations have been also imaged postmortem within 28 days.}
}
@inproceedings{ISMRM2018_4046,
annote={ISMRM2018_4046},
pages={4046},
file={ISMRM2018_4046.pdf:ISMRM2018_4046.pdf:PDF},
title={Experimental demonstration of a {HIFU} self-scanning treatment in moving tissue using hybrid ultrasound and {MR} guidance},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4046.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Orane Lorton and Laura Gui-Lévy and Pauline Guillemin and Nadia Möri and Philippe Cattin and Sylvain Terraz and Christoph Becker and Rares Salomir},
abstract={MRI-controlled tumor treatment by High Intensity Focused Ultrasound (HIFU) is challenging in the abdominal organs because of the breathing motion. We experimentally demonstrated a self-scanning method for motion compensation by passively scanning the tissue passing through the static focal point. Ex vivo turkey samples were subjected to a breathing-like non-periodic motion and the HIFU power was modulated using the velocity information from landmark tracking on simultaneous ultrasound images. MR imaging provided targeting and on-line thermometry. Temperature map were computed using the reference-less PRFS method. A dramatic improvement of the isotherms uniformity score was achieved for rectilinear volumetric ablation.}
}
@inproceedings{ISMRM2018_4047,
annote={ISMRM2018_4047},
pages={4047},
file={ISMRM2018_4047.pdf:ISMRM2018_4047.pdf:PDF},
title={Feasibility of {MR} guided High Intensity Focused Ultrasound ({MR}g{HIFU}) for treating recurrent gynecological tumours: a pilot study},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4047.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Sharon L Giles and Ian Rivens and Katja De Paepe and Veronica A Morgan and Georgios Imseeh and Gail R ter Haar and Alexandra Taylor and Nandita M deSouza},
abstract={MR guided high intensity focused ultrasound (MRgHIFU) treatment plans were generated for 16 patients with recurrent gynecological tumors. Treatment volumes (i) ignoring risk to non-target regions (TV
unconstrained), (ii) considering risk, assuming that patients were optimally prepared (TV
optimal) and (iii) assuming no preparation was possible (TV
no-prep), were compared with planning target volume (PTV). 9/16 patients (56\%) with tumor volumes ≤53 ml were considered feasible to treat safely if optimally prepared (TV
optimal≥50\% PTV). Main limiting factors were transducer focal range, bone in the beam path and risk to bowel. However, even without preparation, 4/16 patients (25\%) remained feasible to treat (TV
no-prep ≥50\% PTV).}
}
@inproceedings{ISMRM2018_4048,
annote={ISMRM2018_4048},
pages={4048},
file={ISMRM2018_4048.pdf:ISMRM2018_4048.pdf:PDF},
title={Feasibility of {MR} guided High Intensity Focused Ultrasound ({MR}g{HIFU}) for treating recurrent gynecological tumours: comparing T2W imaging and diffusion weighted imaging ({DWI}) for treatment planning},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4048.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Sharon L Giles and Jessica M Winfield and Ian Rivens and Katja De Paepe and Veronica A Morgan and Georgios Imseeh and Gail R ter Haar and Alexandra Taylor and Nandita M deSouza},
abstract={MR guided high intensity focused ultrasound (MRgHIFU) treatment plans were generated for 16 patients with recurrent gynecological tumors. Gross tumor volumes (GTV) defined on diffusion-weighted imaging using an echo-planar and turbo-spin echo technique (EPI-DWI, TSE-DWI) were approximately 20\% smaller than GTV defined on T2W imaging, but did not result in sequence-dependent differences in planning target volume (PTV). PTVs were more easily defined on DWI. However, there were clinically relevant discrepancies (>4 mm) between T2-defined and DWI-defined PTV locations, worst in the phase-encode direction using EPI-DWI, that need to be accounted for if incorporating DWI into MRgHIFU treatment planning.}
}
@inproceedings{ISMRM2018_4049,
annote={ISMRM2018_4049},
pages={4049},
file={ISMRM2018_4049.pdf:ISMRM2018_4049.pdf:PDF},
title={Shear stiffness determination using {MR}-acoustic radiation force imaging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4049.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Bradley D. Bolster, Jr. and Henrik Odéen and Hailey McLean and Dennis L. Parker and Allison Payne},
abstract={
Magnetic resonance acoustic radiation force imaging (MR-ARFI) has been used pre-clinically to detect tissue displacement changes during magnetic resonance guided focused ultrasound treatments. Although displacement is a quantitative metric, shear stiffness is typically used to clinically describe disease states. This work develops and evaluates a model-based technique to determine tissue shear stiffness from MR-ARFI displacement measurements. The MR-ARFI derived values are compared to conventional MR elastography shear stiffness values in a phantom study.}
}
@inproceedings{ISMRM2018_4050,
annote={ISMRM2018_4050},
pages={4050},
file={ISMRM2018_4050.pdf:ISMRM2018_4050.pdf:PDF},
title={Optical tracking-guided {MR}-{ARFI} for targeting focused ultrasound neuromodulation},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4050.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Sumeeth V Jonathan and M Anthony Phipps and Vandiver L Chaplin and Aparna Singh and Pai-Feng Yang and Allen T Newton and John C Gore and Li Min Chen and Charles F Caskey and William A Grissom},
abstract={Magnetic resonance-acoustic radiation force imaging (MR-ARFI) pulse sequences permit localization and targeting during focused ultrasound (FUS) therapy. MR-ARFI uses motion-encoding gradients (MEGs) to visualize the tissue displacement caused by the acoustic beam’s radiation force. However, a priori knowledge of the acoustic beam’s position and orientation in space is critical for MR-ARFI so that the MEGs can be placed in the proper orientation. We used an optical tracking system to inform the geometry of MR-ARFI acquisitions. The proposed methods will be used to guide ongoing experiments that use MR-ARFI to produce acoustic beam maps for targeting ultrasound neuromodulation in real-time.}
}
@inproceedings{ISMRM2018_4051,
annote={ISMRM2018_4051},
pages={4051},
file={ISMRM2018_4051.pdf:ISMRM2018_4051.pdf:PDF},
title={Model Predictive control of {MRI}-guided {HIFU} for Hyperthermia},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4051.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Lukas Christian Sebeke and Xi Luo and Bram de Jager and Edwin Heijman and WMPH Heemels and Holger Grüll},
abstract={Hyperthermia has been shown in clinical trials to strongly enhance therapeutic efficacy of radio- and chemotherapy. The main challenge in hyperthermia is to achieve spatially homogenous temperatures between about 41-43
oC for ca. one hour.
Magnetic
Resonance Imaging-guided
High
Intensity
Focussed
Ultrasound (MR-HIFU) enables heating of tissues with high spatial accuracy. We developed a new regulatory algorithm based on
Model
Predictive
Control (MPC) for stable MR-HIFU-hyperthermia, which is designed to find effective heating patterns based on predictions of the temperature evolution in tissue. A comparison with the currently available controller is presented, detailing advantages, shortcomings and opportunities.}
}
@inproceedings{ISMRM2018_4052,
annote={ISMRM2018_4052},
pages={4052},
file={ISMRM2018_4052.pdf:ISMRM2018_4052.pdf:PDF},
title={Development of an 8-channel head array for {MRI} guided monkey ultrasound stimulation},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4052.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jo Lee and Xing Yang and Qiaoyan Chen and Changjun Tie and Xiaojing Long and Nan Li and Xiaoliang Zhang and Hairong Zheng and Ye Li},
abstract={For flexible operating the ultrasound probe in a monkey model, all three instruments, stereotaxic instrument, ultrasound probe and monkey RF coil, must match to each other. In this study, an 8-channel monkey coil was custom-designed to fit the specific stereotaxic instrument, ultrasound probe and the rhesus monkey’s head in order to get a high quality images and efficient ultrasound operation. Compared to the commercial small flexible coil array, the custom-designed monkey coil provides higher SNR in all three orientations, higher spatial resolution in vivo and better parallel imaging capability.}
}
@inproceedings{ISMRM2018_4053,
annote={ISMRM2018_4053},
pages={4053},
file={ISMRM2018_4053.pdf:ISMRM2018_4053.pdf:PDF},
title={Monitoring High Intensity Focused Ultrasound ({HIFU}) ablations in real time using interventional {MR} Elastography ({MRE})},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4053.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jonathan Vappou and Paolo Cabras and Kisoo Kim and Pramod Rao and Afshin Gangi and Elodie Breton},
abstract={This study introduces the use of interventional Magnetic Resonance Elastography (iMRE) for monitoring HIFU ablations, using the acoustic radiation force as a means for generating the shear waves necessary for MRE directly from the HIFU focus. This method allows for monitoring tissue elasticity and temperature in real time during the ablation. Its feasibility is illustrated in vivo on porcine muscle. Tissue was found to stiffen significantly (+125\%) when the temperature increased and changes in tissue stiffness were found to be irreversible. These findings suggest that tissue stiffness may be an interesting biomarker, complementary to thermal dose, to monitor HIFU ablations.}
}
@inproceedings{ISMRM2018_4054,
annote={ISMRM2018_4054},
pages={4054},
file={ISMRM2018_4054.pdf:ISMRM2018_4054.pdf:PDF},
title={Longitudinal Observation of Focused Ultrasound Induced Blood-Brain Barrier Opening of Cat Brain from 7-T Contrast-Enhanced {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4054.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Xianfeng Feng\# and Tingting He\# and Xiao Yu and Chih-Hung Tsai and Wen-Yen Chai and Chao-Ting Wang and Wei Xiong and Bin Xu and Yifeng Fan and Hao-Li Liu* and Hsin-Yi Lai*},
abstract={Blood-brain barrier (BBB) has long been impeding the application of many therapeutic agents in treating diseases in central nervous system. Results showed that microbubble-mediated focused ultrasound can open BBB in cats noninvasively and locally. The size and duration of BBB opening can be accurately monitored by 7T MRI longitudinally. The combination of two techniques has the potential to be further applied for further clinical practice in the future.
}
}
@inproceedings{ISMRM2018_4055,
annote={ISMRM2018_4055},
pages={4055},
file={ISMRM2018_4055.pdf:ISMRM2018_4055.pdf:PDF},
title={Magnetic resonance imaging of patients with conventional and {MR}-conditional pacemakers: assessment of risk and incidence},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4055.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Markus Fahlström and Johan Olsrud and Tomas Bjerner and Elna-Marie Larsson and Carina Blomström-Lundqvist},
abstract={Magnetic resonance imaging of patients with conventional- and MR-conditional pacemakers should be considered and may be considered respectively, based on a case-by-case risk-benefit assessment. However, information regarding incidence of risks with respect to exposure to different electromagnetic fields is limited. Based on a literary review, risk, complications and incidence was assessed. Most common risk/complication is reed switch activation. Electrode heating is a relevant risk, with minor clinical implication. Off-label MR-examinations of MR-conditional pacemakers or abandoned leads may be considered.}
}
@inproceedings{ISMRM2018_4056,
annote={ISMRM2018_4056},
pages={4056},
file={ISMRM2018_4056.pdf:ISMRM2018_4056.pdf:PDF},
title={Safety of Active Catheters in {MRI}: Termination Impedance vs. {RF}-induced Heating},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4056.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ali Caglar Özen and Thomas Lottner and Michael Bock},
abstract={RF-induced heating of the active catheters was analyzed and analytically modeled to demonstrate that it can be controlled by adjusting the termination impedance. Current distribution of a single-loop active guiding catheter was formulated as a function of the incident electric field, propagation constants and termination impedances. The tip SAR was displayed on a color-coded Smith chart in terms of the normalized input impedance. For the first time, analytical modeling and transfer function measurements were applied to active catheters. A novel signal level and impedance control unit was introduced, which is applicable also to other interventional devices.}
}
@inproceedings{ISMRM2018_4057,
annote={ISMRM2018_4057},
pages={4057},
file={ISMRM2018_4057.pdf:ISMRM2018_4057.pdf:PDF},
title={Assessment of Iron Oxide Nanoparticle Concentration for Distinct Intercranial {EEG} Electrode Localization in {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4057.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Johannes B. Erhardt and Jessica A. Martinez and Tyler E Cork and Isabel Gessner and Sanjay Mathur and Thomas Stieglitz and Daniel B. Ennis},
abstract={IcEEG electrodes for epilepsy and research applications impair fMRI and MR images with compromising susceptibility artifacts. Thin-film implants feature 100x less metal thickness and thus minimal artifacts. However, thin-film implants are inconspicuous in MRI. Therefore we present means of localization using super paramagnetic iron oxide nano particles to make thin-film implants ready for future applications. We present feasible concentrations and proof of concept.}
}
@inproceedings{ISMRM2018_4058,
annote={ISMRM2018_4058},
pages={4058},
file={ISMRM2018_4058.pdf:ISMRM2018_4058.pdf:PDF},
title={Adaptive {SAR} mass-averaging to predict {RF} heating for B1 shimming in the presence of a hip implant for parallel transmit at 3T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4058.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Aurelien Destruel and Kieran O'Brien and Markus Barth and Jin Jin and Feng Liu and Stuart Crozier},
abstract={Parallel-transmit and B
1-shimming techniques may significantly reduce radiofrequency (RF) artefacts when imaging near metal implants at 3T; however, it is known that around metal implants the 10g-averaged specific-absorption-rate (SAR
10g) locations do not coincide with the location of maximum heating. In this work, we investigate the behaviour of the B
1 field and RF heating around metal implants in a generic body coil at 3T as a function of shimming parameters using the adaptive SAR method we previously introduced as a fast estimate of temperature increase.}
}
@inproceedings{ISMRM2018_4059,
annote={ISMRM2018_4059},
pages={4059},
file={ISMRM2018_4059.pdf:ISMRM2018_4059.pdf:PDF},
title={Experience with 7 Tesla {MRI} of human subjects with passive implants and tattoos: an update},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4059.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Oliver Kraff and Raphaela M Berghs and Yacine Noureddine and Mark E Ladd and Harald H Quick},
abstract={In this retrospective study, questionnaires and screening forms were analyzed to identify all subjects with implants and/or tattoos cleared for imaging at our passively shielded 7T whole-body MR system. Over the past 11 years, 496 out of 2370 healthy volunteers and volunteers with known pathologies had implants and/or tattoos and underwent a 7T MR examination. None of the subjects reported any discomfort related to heating or force during or after imaging. No findings regarding safety occurred and all examinations could be safely performed.}
}
@inproceedings{ISMRM2018_4060,
annote={ISMRM2018_4060},
pages={4060},
file={ISMRM2018_4060.pdf:ISMRM2018_4060.pdf:PDF},
title={Estimation of {RF}-induced temperature rise for helix and straight leads based on the lead electromagnetic model: a case study},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4060.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Mikhail Kozlov and Wolfgang Kainz},
abstract={This case study investigated RF-induced heating of straight and helix leads at 127.7 MHz obtained with the lead electromagnetic model (LEM) and direct 3D electromagnetic and thermal co-simulations. A large set of incident electric fields was generated in a phantom by an array of four antennas with varying spatial positions and sources. LEM was a suitable approach for predicting temperature in close proximity to the end face of lead tip. However the variance of the fitted values and observed values was rather high for temperature at other locations around the lead tip.}
}
@inproceedings{ISMRM2018_4061,
annote={ISMRM2018_4061},
pages={4061},
file={ISMRM2018_4061.pdf:ISMRM2018_4061.pdf:PDF},
title={{RF} Safety of Transcranial Direct Current Stimulation Equipment during {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4061.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Mikhail Kozlov and Roland Müller and Andre Pampel and Benjamin Kalloch and Nikolaus Weiskopf and Harald E. Möller},
abstract={We calculated the RF-induced power deposition at 3T due to the presence of tDCS equipment using an approximation of the human body by a single tissue numerical model. Influences of the tDCS lead including a built-in serial resistor on the power deposition were evaluated. Our case study provided strong evidence that the tDCS setup has a relevant impact on power deposition in proximity of the electrode edges at 3T. These particular conditions are not explicitly considered in the procedures that are used for SAR monitoring on the MRI scanner. The peak voltage across the serial resistor has to be carefully considered in terms of sufficient electrical strength to safely prevent sparks.}
}
@inproceedings{ISMRM2018_4062,
annote={ISMRM2018_4062},
pages={4062},
file={ISMRM2018_4062.pdf:ISMRM2018_4062.pdf:PDF},
title={Temperature measurements in a phantom during a 1.5T {MRI} in the presence of a µ{MS} implant.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4062.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Giorgio Bonmassar and Kuldeepsinh Rana and Frederick Haer and Laleh Golestanirad},
abstract={The technology consists of nanoscale structures for developing micro and nano-scale coils for microscopic magnetic stimulation of brain tissue. This technology will provide an important new tool for further exploration of micro-magnetic stimulation as a prospective tool for clinical and preclinical applications. In this abstract, we have shown that the technology is amenable of MRI imaging with low heating.}
}
@inproceedings{ISMRM2018_4063,
annote={ISMRM2018_4063},
pages={4063},
file={ISMRM2018_4063.pdf:ISMRM2018_4063.pdf:PDF},
title={Torque abnormality of Ti alloy in a static magnetic field},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4063.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Minghui Tang and Shingo Kawahira and Naoyuki Nomura and Toru Yamamoto},
abstract={Ti alloy has been introduced for medical implants to reduce MRI artifacts for its lower susceptibility than the preceding material of Elgiloy. The magnetic torque of metallic materials theoretically increases with an increase in the susceptibility. However, it was reported that the torque of cerebral aneurysm clips was comparable for both materials. In this study, we accurately measured the torque of Elgiloy and Ti alloy rods in an MR scanner and found that the small susceptibility anisotropy of Ti alloy rod causes a torque that is more than 100 times of the value expected from the conventional torque theory.}
}
@inproceedings{ISMRM2018_4064,
annote={ISMRM2018_4064},
pages={4064},
file={ISMRM2018_4064.pdf:ISMRM2018_4064.pdf:PDF},
title={A Prospective Study of the Safety of Tattoos in {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4064.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Martina F Callaghan and Clive Negus and Megan Creasey and Shiela Burns and Janice Glensman and David Bradbury and Elaine Williams and Nikolaus Weiskopf},
abstract={Tattoos are recognised as a potential source of increased risk for MRI. Here we present the results of a prospective study designed to assess the risk of a tattoo-related adverse event occurring during MRI scanning at 3T. The study spanned a 6 year period with 573 independent scanning sessions on 319 individuals. With the inclusion criteria adopted in this study, the probability of an adverse reaction was estimated to be < 1\%.}
}
@inproceedings{ISMRM2018_4065,
annote={ISMRM2018_4065},
pages={4065},
file={ISMRM2018_4065.pdf:ISMRM2018_4065.pdf:PDF},
title={Image-Based {MR} Safety Evaluation of Heating in Implanted Devices},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4065.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Samuel Rob Guyer and Ken Sakaie and Se-Hong Oh and Stephen Jones},
abstract={A thermal contrast agent with high sensitivity, thulium 1,4,7,10-tetramethyl-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate (TmDOTMA
-), was investigated for use in measuring the three-dimensional heating profile surrounding implantable devices with a goal of simplifying the safety assessment process. The technique was first demonstrated by imaging a vertical temperature gradient and was subsequently used to measure the heating profile surrounding a copper wire. We found gross agreement of this technique with concurrent fiber-optic temperature probe measurements, with the TmDOTMA
- measurement complicated by a number of technical challenges and imaging artifacts.}
}
@inproceedings{ISMRM2018_4066,
annote={ISMRM2018_4066},
pages={4066},
file={ISMRM2018_4066.pdf:ISMRM2018_4066.pdf:PDF},
title={Reducing heating of implanted leads through High-Dielectric Capacitive Bleeding of Current ({HD}-{CBLOC}): concepts, simulations and experimental results},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4066.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Laleh Golestani Rad and Lawrence L Wald and Boris Keil and Giorgio Bonmassar},
abstract={RF heating of conductive implants such as those in cardiac pacemakers and deep brain stimulation devices remains a major issue limiting access to MRI for hundreds of thousands of patients. Here we present a novel technique we call High-Dielectric Capacitive Bleeding of Current (HD-CBLOC) to develop an implanted lead with significantly reduced RF heating. The lead uses a high-permittivity insulating coating around the conductive wires to enable a distributed capacitive dissipation of RF currents along the length of the lead and thus reducing the energy deposition at the tip. Experiments show the configuration reduces heating by more than 15-fold during scans at 1.5 T. Simulations predict a similar effect at 3T and 7T.}
}
@inproceedings{ISMRM2018_4067,
annote={ISMRM2018_4067},
pages={4067},
file={ISMRM2018_4067.pdf:ISMRM2018_4067.pdf:PDF},
title={Generation of a “virtual population” of deep brain stimulation patient models for {MRI} safety studies},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4067.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Bastien Guerin and Mathias Davids and Darin Dougherty and Leonardo Angelone and Lawrence L. Wald},
abstract={We develop and disseminate a “virtual population” of five deep brain stimulation (DBS) patient models. The models are high-quality, watertight, topologically correct, non-intersecting surface meshes that can be used in conjunction with Finite Element Method (FEM) tools such as Ansys HFSS and CST. They are realistic descriptions of actual DBS patients anatomy (internal air, bone and “average tissue”) as well as the entire DBS path including the Implantable Pulse Generator (IPG) and extension cables. We hope the models can be useful for assessment of inter-subject variability of RF-safety metrics such as SAR and temperature.}
}
@inproceedings{ISMRM2018_4068,
annote={ISMRM2018_4068},
pages={4068},
file={ISMRM2018_4068.pdf:ISMRM2018_4068.pdf:PDF},
title={Measuring Radio-Frequency Induced Currents On Metallic Leads Using Parallel Imaging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4068.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yigitcan Eryaman and Sean Moen and Andrea Grant and Gregor Adriany and Kamil Ugurbil and Noam Harel and J. Thomas Vaughan},
abstract={We present a method that can be used to calculate the RF induced currents flowing on metallic leads. Proposed method relies on analyzing MR magnitude images (acquired by parallel imaging) and modeling/matching the null location at the vicinity of the lead. The calculated induced current can be used to predict safe excitation scenarios and reduce heating around the lead.}
}
@inproceedings{ISMRM2018_4069,
annote={ISMRM2018_4069},
pages={4069},
file={ISMRM2018_4069.pdf:ISMRM2018_4069.pdf:PDF},
title={{MRI} Implant Safety: Novel Mechanistic Model and Safety Assessment Approach for Small Implants and Abandoned Leads},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4069.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ilaria Liorni and Esra Neufeld and Sven Kuehn and Manuel Murbach and Niels Kuster},
abstract={Safety assessment of active implants is defined in the technical specification ISO/TS 10974. However, the safety of small passive implants must be assessed individually for each device, e.g., via the ASTM F2182-11a standard test method. Computational studies have demonstrated that the mechanism postulated for elongated implants at 64 MHz is not applicable. We propose a new mechanistic theory of general validity applicable across a large frequency range to describe exposure enhancement at critical lead locations. Simulation-based assessment was successfully compared to predictions from the mechanistic model on the impact of several parameters (tissue dielectric properties, insulation thickness and tip shape).}
}
@inproceedings{ISMRM2018_4070,
annote={ISMRM2018_4070},
pages={4070},
file={ISMRM2018_4070.pdf:ISMRM2018_4070.pdf:PDF},
title={Measuring dB/dt Induced Vibration in Medical Devices: Comparison of Discrete Frequencies Versus Use of a Variable-Frequency Chirp Pulse},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4070.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Christine M. Tarapacki and Daniel J. Martire and Colin M. McCurdy and William B. Handler and Blaine A. Chronik},
abstract={Determining gradient field-induced vibration of a device typically involves multiple measurements at discrete frequencies. This study compares data from a frequency chirp to discrete frequencies in an effort to decrease testing time and obtain a larger range of information. Results confirm scaled displacement obtained through discrete frequency measurements and a frequency chirp matched for all measured frequencies.}
}
@inproceedings{ISMRM2018_4071,
annote={ISMRM2018_4071},
pages={4071},
file={ISMRM2018_4071.pdf:ISMRM2018_4071.pdf:PDF},
title={Development of a standard reference object for monitoring quality and reproducibility in dB/dt-heating tests for medical devices},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4071.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Christine M. Tarapacki and Jack Hendriks and Krzysztof Wawrzyn and William Bradfield Handler and Blaine A. Chronik},
abstract={The intent of this study is to introduce and characterize a standard reference object for gradient-induced dB/dt heating studies. Key attributes of a standard reference object would be simplicity, sensitivity (large response to exposure conditions) and reproducibility. Various geometries, materials and exposure conditions were studied and the results indicate the temperature rise of a simple copper annulus can be used to verify all components of a dB/dt exposure and measurement system are functioning prior to a device test. The thermal response of a 5-cm diameter copper annulus was characterized as a function of frequency and dB/dt-amplitude, both in air and in tissue-mimicking gel.}
}
@inproceedings{ISMRM2018_4072,
annote={ISMRM2018_4072},
pages={4072},
file={ISMRM2018_4072.pdf:ISMRM2018_4072.pdf:PDF},
title={{MR} based transfer matrix determination for a linear implant by joint estimation of the incident and scattered B$^+_1\hspace{2mm}$fields.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4072.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Janot P. Tokaya and Alexander J.E. Raaijmakers and Alessandro Sbrizzi and Peter R. Luijten and Cornelis A.T. Berg},
abstract={Two findings that are steps towards fully MR-based TF determination in realistic situations are presented. Firstly, the transfer matrix, that is an extension of the transfer function (TF), can describe the RF response of an implant in a human model. Secondly, a joint minimization of the incident field and the scattered field, determined with the transfer matrix, can describe measured and simulated complex B$_1^+$ distributions in a phantom with a linear implant present. The TM and TF result from this minimization, which enables their determination from a single MRI acquisition with the implant in place.}
}
@inproceedings{ISMRM2018_4073,
annote={ISMRM2018_4073},
pages={4073},
file={ISMRM2018_4073.pdf:ISMRM2018_4073.pdf:PDF},
title={A robust experimental evaluation method for {RF} safety assessment of implants during 1.5 T and 3.0 T {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4073.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Aiping Yao and Earl Zastrow and Niels Kuster},
abstract={The accuracy of the traditional SAR-based evaluation is normally limited by the extreme spatial gradient of the induced SAR within the high-heating region. In this work, we propose a reconstruction evaluation method that improves upon the traditional method by using simple numerical modeling and image processing algorithm. The total combined uncertainty caused by the high SAR gradient and limited probe resolution is reduced dramatically from 3dB to 1 dB with the proposed method. A generic implant with helical conductor and single electrode is successfully validated against numerical simulations with less than 0.5 dB deviation at both 1.5 T and 3.0 T MRI RF frequencies.}
}
@inproceedings{ISMRM2018_4074,
annote={ISMRM2018_4074},
pages={4074},
file={ISMRM2018_4074.pdf:ISMRM2018_4074.pdf:PDF},
title={Power to temperature conversion of {AIMD} under {RF} exposure},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4074.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Aiping Yao and Earl Zastrow and Niels Kuster},
abstract={Determining the local tissue temperature rise caused by the RF-induced deposition of an active implantable medical device (AIMD) requires a conversion between localized power deposition to temperature (p2∆T). We investigate the quasi-static limit by which both the distributions of power and temperature are assumed to depend only on the electrode geometry (when electrically small) and independent of the current distribution along the AIMD’s wire conductor. The results confirm that p2∆T conversion can be derived without the knowledge of incident conditions to the AIMD and complete geometry of the AIMD. The relationship between p2∆T and the electrode physical geometries is summarized.}
}
@inproceedings{ISMRM2018_4075,
annote={ISMRM2018_4075},
pages={4075},
file={ISMRM2018_4075.pdf:ISMRM2018_4075.pdf:PDF},
title={{MRI} {RF} Safety of Active Implantable Medical Devices ({AIMD}s): Effect of Conductivity of Tissue Simulating Media on Device Model Accuracy},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4075.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Krishna K.N. Kurpad and Jingshen Liu and Paul J Stadnik and Jeffrey Von Arx and Larry Stotts and Wolfgang Kainz and Ji Chen},
abstract={The Tier 3 procedure for testing electrically long active implantable medical devices (AIMDs) for MRI RF safety involves the development of transfer function models (TFMs) of the AIMDs. Accuracy of the TFM depends on how closely the TSM mimics the tissues in which the AIMD is implanted. We find that the conductivity of the medium surrounding the lead electrode has a strong influence on the transfer function magnitude of the DUT. Therefore, TFMs of the DUT developed in a TSM whose conductivity mimics that of the in-vivo tissue that surrounds the electrode under test results in the most accurate TFM.}
}
@inproceedings{ISMRM2018_4076,
annote={ISMRM2018_4076},
pages={4076},
file={ISMRM2018_4076.pdf:ISMRM2018_4076.pdf:PDF},
title={Analysis on pulse shape and temporal resolution effects on {RF} heating with medical implants},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4076.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yuqing Wan and Shiloh Sison},
abstract={MRI RF heating can potentially lead to thermal damages to biological tissues, especially for patients with medical implants, because the RF E-field may induce currents along the implant, leading to concentrated power deposition at implant-tissue interface. Previous methods for computing temperature change through MR scans indicated minimal effect from temporal resolution between 30s and 120s for patients without implants. However, for patients with medical implants, our study suggests that temperature/thermal dose is predicted more accurately with smaller time step sizes (<10s), because immediate response to the heating (increased blood perfusion) needs to be accounted for in a timely fashion.}
}
@inproceedings{ISMRM2018_4077,
annote={ISMRM2018_4077},
pages={4077},
file={ISMRM2018_4077.pdf:ISMRM2018_4077.pdf:PDF},
title={Investigation of breast imaging {SAR} hotspot with posable human models},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4077.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Xin Chen and Michael Steckner},
abstract={MR users are routinely instructed to eliminate large conducting loops in order to avoid skin/skin contact RF burns. Loops can be formed by skin folds, hands clasped (e.g. above head or on abdomen), hands touching thighs, or touching legs etc. Points of skin/skin contact are often associated with significant local SAR. Modeling with posable human models show that hands clasped skin/skin contact loops associated with prone breast imaging do not necessarily increase local SAR. This suggests that not all skin/skin contact situations are a patient safety concern.}
}
@inproceedings{ISMRM2018_4078,
annote={ISMRM2018_4078},
pages={4078},
file={ISMRM2018_4078.pdf:ISMRM2018_4078.pdf:PDF},
title={Design And Evaluation Of Head And Neck Low {SAR} {MRI} Protocols For Patients With Implanted Electronic Devices},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4078.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jessica A. Martinez and Kévin Moulin and Pablo Villablanca and Daniel B. Ennis},
abstract={Patients with MRI conditional implantable electronic devices (IEDs) will be referred for MRI examinations. Imaging these patients, however, remains a challenge, in part, because there is no framework to follow for designing protocols that meet SAR labeling requirements. The purpose of this work was to generate and test a workflow that can be followed for optimizing protocols to meet a SAR labeling target. Following the workflow, we optimized head and neck protocols to meet whole-body SAR ≤0.1W/kg and head SAR≤0.3W/kg. Each low SAR MRI series was within the conditional SAR labeling while maintaining image quality.
}
}
@inproceedings{ISMRM2018_4079,
annote={ISMRM2018_4079},
pages={4079},
file={ISMRM2018_4079.pdf:ISMRM2018_4079.pdf:PDF},
title={Comprehensive head motion modelling and correction using simultaneously acquired {MR} and {PET} data},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4079.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Francesco Sforazzini and Jakub Baran and Alexandra Carey and Nadim Jon Shah and Gary Egan and Zhaolin Chen},
abstract={Head motion is one of the major issues in neuroimaging. With the introduction of MR-PET scanners, motion parameters can now be estimated from two independent modalities acquired simultaneously. In this work, we propose a new data-driven method that combines MR image registration and PET data driven approach to model head motion during the complete course of MR-PET examination. Without changing the MR-PET acquisition protocol, the proposed method provides motion estimates with a temporal resolution of ~2 secs. Results on a phantom dataset show that the proposed method can significantly reduce motion artefact in brain PET images and improve image sharpness compared with the MR based methods.}
}
@inproceedings{ISMRM2018_4080,
annote={ISMRM2018_4080},
pages={4080},
file={ISMRM2018_4080.pdf:ISMRM2018_4080.pdf:PDF},
title={Fast and Robust: Prospective Motion Correction Combined with Compressed Sensing for 3D Time-of-Flight {MRA}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4080.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Christoph Forman and Michaela Schmidt and Peter Speier and Martin Schramm and Steffen Schroeter and Daniel Nicolas Splitthoff and Tobias Kober},
abstract={We present the combination of prospective motion correction and compressed sensing for 3D Time-of-Flight MRA. This enables fast TOF imaging in high isotropic resolution, while preserving image quality and diagnostic value even in the presence of motion. The method was evaluated in five healthy volunteers and image quality was compared to a conventional TOF MRA. Prospective motion compensation successfully enabled robust diagnostic image quality in the highly accelerated scan. The promising results as well as the full integration of the proposed method in a standard clinical scanner enable a comprehensive evaluation in patients in the near future.}
}
@inproceedings{ISMRM2018_4081,
annote={ISMRM2018_4081},
pages={4081},
file={ISMRM2018_4081.pdf:ISMRM2018_4081.pdf:PDF},
title={Fast and Accurate 3D Rigid-Body Motion Information From Spherical Lissajous Navigators at Small K-Space Radii},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4081.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Richard Buschbeck and N. Jon Shah},
abstract={A new navigator concept is presented which enables the measurement of accurate rigid-body motion information from spherical navigators at extremely small k-space radii. This is achieved by using a 3D Lissajous navigator trajectory and a rotation estimation algorithm known from computer vision. The new method provides motion information with sufficient accuracy and precision for many motion correction techniques and significantly outperforms current spherical navigator methods in terms of acquisition and computation time.}
}
@inproceedings{ISMRM2018_4082,
annote={ISMRM2018_4082},
pages={4082},
file={ISMRM2018_4082.pdf:ISMRM2018_4082.pdf:PDF},
title={Slice-wise motion tracking during simultaneous {EEG}-f{MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4082.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Malte Laustsen and Mads Andersen and Patrick M. Lehmann and Rong Xue and Kristoffer H. Madsen and Lars G. Hanson},
abstract={Slice-wise motion tracking during combined electroencephalography (EEG) and echo planar imaging (EPI) is developed. Using gradient-induced noise on the EEG for tracking, no interleaved navigator modules or additional hardware is needed. The motion parameters are determined after a calibration and training scan. The method is explored in a phantom and in vivo.}
}
@inproceedings{ISMRM2018_4083,
annote={ISMRM2018_4083},
pages={4083},
file={ISMRM2018_4083.pdf:ISMRM2018_4083.pdf:PDF},
title={Zero-Dimensional Self Navigated Autofocus for Motion Corrected Magnetic Resonance Fingerprinting},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4083.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Gastao Cruz and René M Botnar and Claudia Prieto},
abstract={Magnetic Resonance Fingerprinting (MRF) provides simultaneous multi-parametric maps from a continuous transient state acquisition of many time-point images. Motion occurring during the MRF acquisition can create artefacts in the consequent T
1/T
2 maps. Here we propose to derive an intermediate 1D motion model from the acquired MRF data itself via self-navigation of the k-space central point and further refine the motion estimates using an autofocus algorithm for MRF motion correction. The proposed approach was evaluated in simulations.}
}
@inproceedings{ISMRM2018_4084,
annote={ISMRM2018_4084},
pages={4084},
file={ISMRM2018_4084.pdf:ISMRM2018_4084.pdf:PDF},
title={Segmented 3D fat navigators for faster brain motion tracking at 7T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4084.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Frédéric Gretsch and Daniel Gallichan},
abstract={Fat Navigators have previously demonstrated their utility for high-accuracy motion tracking. We investigate a segmented 3D version of the navigators which allows significant acquisition time reduction while maintaining high motion accuracy.}
}
@inproceedings{ISMRM2018_4085,
annote={ISMRM2018_4085},
pages={4085},
file={ISMRM2018_4085.pdf:ISMRM2018_4085.pdf:PDF},
title={Evaluating the influence of motion on {FISP}-{MRF}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4085.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Gregor Körzdörfer and Peter Speier and Steffen Schröter and Martin Schramm and Josef Pfeuffer and Bernhard Hensel and Mathias Nittka},
abstract={Magnetic Resonance Fingerprinting (MRF) is an MR technique that generates parameter maps by matching pseudo randomly generated MR signals to a precalculated dictionary. MRF sequences in general consist of a long series of closely spaced excitations. An assumption underlying MRF is that a partially motion-corrupted signal is not able to significantly alter results. Corrupted signal segments are supposed to have no respective counterpart in the dictionary and therefore do not affect the pattern match. This assumption is evaluated in this study. Controlled motion was added to phantom and in vivo MRF experiments and the results were related to realistic patient movement recorded by a 3D camera system.}
}
@inproceedings{ISMRM2018_4086,
annote={ISMRM2018_4086},
pages={4086},
file={ISMRM2018_4086.pdf:ISMRM2018_4086.pdf:PDF},
title={Evaluating Motion Artifact Correction of the Linearized Geometric Solution in b{SSFP} {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4086.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Michael Nicholas Hoff and Qing-San Xiang},
abstract={The linearized geometric solution (LGS) is known for demodulating balanced steady state free precession (bSSFP) MRI signal of its dependence on magnetic field inhomogeneity, but has also recently shown signs of mitigating motion artifact. Here the extent of motion artifact correction by the LGS is explored via simulations of variable motion schedules, image noise and T1/T2 ratio. It corrects motion artifact to a greater extent than a complex image averaging solution, except in scenarios of low signal-to-noise ratio (SNR). This study motivates clinical applications of bSSFP in imaging fluid structures that normally suffer from motion and/or field inhomogeneity artifacts.}
}
@inproceedings{ISMRM2018_4087,
annote={ISMRM2018_4087},
pages={4087},
file={ISMRM2018_4087.pdf:ISMRM2018_4087.pdf:PDF},
title={Revealing sub-voxel motions of brain tissue using phase-based amplified {MRI} (a{MRI})},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4087.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Itamar Terem and Wendy Ni and Maged Goubran and Greg Zaharchuk and Kristen Yeom and Michael Moseley and Mehmet Kurt and Samantha Holdsworth},
abstract={Problem:Amplified Magnetic Resonance Imaging (aMRI) was recently introduced as a new brain motion detection and visualization method. In this work we strive to improve aMRI by incorporating a phase-based motion amplification algorithm.Methods:Phase-based aMRI was developed, validate using digital phantom simulations and compared with EVM-based aMRI in healthy volunteers at 3T. Data were also acquired on a patient with Chiari I malformation and displacement maps were produced using free form deformation (FFD) of the aMRI output. Results:Phantom simulations showed that phase-based aMRI has a linear dependence of amplified displacement on true displacement. Amplification was independent of temporal frequency, phantom size, Rician noise and partial volume effect, but had a slight dependence on phantom shape. Phase-based aMRI supported larger amplification factors than EVM-based aMRI and was less sensitive to noise and artifacts. Abnormal biomechanics were seen on FFD maps of the Chiari I malformation patient.Conclusion:Phase-based aMRI can be used for quantitative analysis of minute changes in brain motion and may reveal subtle physiological variations of the brain due to pathology. Preliminary data shows the potential of phase-based aMRI to assess abnormal biomechanics in Chiari I malformation.}
}
@inproceedings{ISMRM2018_4088,
annote={ISMRM2018_4088},
pages={4088},
file={ISMRM2018_4088.pdf:ISMRM2018_4088.pdf:PDF},
title={A Comparison of Prospective versus Retrospective Motion Correction for Reliable T1-Weighted Neuroimaging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4088.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Steven Kecskemeti and Abigail Freeman and Andrew Alexander},
abstract={Prospective motion corrected MPRAGE T1-weighted images were compared against retrospectively motion corrected MPnRAGE T1-weighted images. 14 young children were scanned without sedation and without the head being stabilized with pads. Dice-overlap of automatic tissue segementation masks (FAST and FLIRT) were used as a measure of reliability. MPnRAGE with motion correction showed exceptional regional label consistency (>=80\% Dice overlaps for all 16 regions and >90\% in 12 of the regions). Conversely, MPRAGE-PROMO demonstrated lower performance than even MPnRAGE without motion correction.}
}
@inproceedings{ISMRM2018_4089,
annote={ISMRM2018_4089},
pages={4089},
file={ISMRM2018_4089.pdf:ISMRM2018_4089.pdf:PDF},
title={Combined prospective motion correction and retrospective B0 correction for {EPI} using optical tracking and predictive B0 maps.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4089.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={James Smith and Olivier Mougin and Kingkarn Aphiwatthanasumet and Matthew Clemence and Andrew Peters and Richard Bowtell and Paul Glover and Penny Gowland},
abstract={We demonstrate a combination of prospective motion correction and retrospective B
0 unwarping using predictive field maps to improve the registration of EPI images. Prospective motion correction is performed using an optical tracking camera and custom scanner code. Field maps were generated using a multilinear fit of subject orientation using data gathered at known orientations. Results show a higher correlation when registering EPI data to a high-resolution anatomical, post-correction.}
}
@inproceedings{ISMRM2018_4090,
annote={ISMRM2018_4090},
pages={4090},
file={ISMRM2018_4090.pdf:ISMRM2018_4090.pdf:PDF},
title={Influence of tracking system latency on prospective motion correction},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4090.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Patrick Hucker and Bruno Riemenschneider and Stefan Kroboth and Maxim Zaitsev},
abstract={Tracking latency in prospective motion correction (PMC) with external tracking systems is commonly assumed to influence image quality, however no studies attempted to quantify this effect. This work presents a method to visualize latency-induced artifacts in simulated MR images. At first a MR sequence with PMC is simulated using vendor tools and recorded or synthetic motion with varying latency is added. Thereafter the effective encoding trajectory based on the exported gradient/ADC events is calculated. The resulting trajectory is used to simulate MR data with the inverse FFT, visualizing artifacts due to the tracking latency.}
}
@inproceedings{ISMRM2018_4091,
annote={ISMRM2018_4091},
pages={4091},
file={ISMRM2018_4091.pdf:ISMRM2018_4091.pdf:PDF},
title={A dynamic {MR}-signal model to capture 3D motion-fields at ultra-high frame-rate},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4091.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Niek R.F. Huttinga and Cornelis A.T. van den Berg and Peter R. Luijten and Alessandro Sbrizzi},
abstract={We present a framework that has the potential to capture non-rigid 3D motion at 50 Hz, hereby drastically accelerating state-of-the-art techniques. Our model directly and explicitly relates the motion-field to the k-space data and is independent of the spatial resolution, allowing for extremely high under-sampling. We illustrate proof-of-principle validations of our method through a simulation test and whole-brain 3D in-vivo measured data. Results show that the 3D motion-fields can be reconstructed from extremely under-sampled k-space data consisting of as little as 64 points, enabling 3D motion estimation at unprecedented frame-rates.}
}
@inproceedings{ISMRM2018_4092,
annote={ISMRM2018_4092},
pages={4092},
file={ISMRM2018_4092.pdf:ISMRM2018_4092.pdf:PDF},
title={Contact-Free Respiration Motion Monitoring Using a Markerless Structured Optical System in {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4092.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Chen Zhang and Jin Liu and Jiarui Cai and Haikun Qi and Jinnan Wang and Chun Yuan and Huijun Chen},
abstract={Respiration motion artifacts remain a major problem in MRI, particularly at higher imaging resolution and field strength. In this study, we investigated the feasibility of using a MR-compatible in-bore camera system to perform contactless monitoring of respiratory information during MRI of human subjects. A good match to the respiratory data is apparent in terms of the timing of trough and ICC between trigger intervals from the respiratory belt data and video-derived signals is 0.97, meaning that this optical system can monitor and correct in end-expiratory, in addition to simultaneously detecting random motion based on our previous work.}
}
@inproceedings{ISMRM2018_4093,
annote={ISMRM2018_4093},
pages={4093},
file={ISMRM2018_4093.pdf:ISMRM2018_4093.pdf:PDF},
title={Wasserstein {GAN} for Motion Artifact Reduction of {MR} images},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4093.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Sandro Braun and Pascal Ceccaldi and Xiao Chen and Benjamin Odry and Boris Mailhe and Mariappan Nadar},
abstract={Subject motion is a common artifact in MR acquisition that can severely degrade image quality. We take advantage of the recent advances in deep generative network to compensate motion and generate images of increased quality, measured by evaluating changes in MSSIM and normalized L
2 distance (NRMSE). We trained an image to image network to predict motion compensated magnitude images given motion-corrupted input images, coupled with an adversarial network to help refine those predicted images. For the discriminator loss, we use the Wasserstein objective. The results suggest clear improvements on MSSIM and NRMSE metrics for the majority of cases.}
}
@inproceedings{ISMRM2018_4094,
annote={ISMRM2018_4094},
pages={4094},
file={ISMRM2018_4094.pdf:ISMRM2018_4094.pdf:PDF},
title={Using Machine Learning to accelerate fat-based head motion-navigators – a preliminary simulation study},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4094.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Daniel Gallichan},
abstract={We hypothesise that machine learning approaches could be applied to speed up motion-correction navigators – potentially obviating the need for image reconstruction and co-registration. In this preliminary 2D simulation study we investigate the ability of a simple 5-layer convolutional neural network to predict motion-parameters based on difference images between two head poses. Our results indicate that the CNN is able to outperform linear regression over the range of parameters tested, supporting our aim to develop this concept in more detailed future work.}
}
@inproceedings{ISMRM2018_4095,
annote={ISMRM2018_4095},
pages={4095},
file={ISMRM2018_4095.pdf:ISMRM2018_4095.pdf:PDF},
title={Deep learning-based real time {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4095.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Vahid Ghodrati and Jiaxin Shao and Ziwu Zhou and Yu Gao and Fadil Abbas Ali and Fei Han and Peng Hu},
abstract={In this work, we use the dilated U-net to reconstruct the dynamic free breathing cine images from regular under sampled raw data. Also, we consider different under sampling rate to determine maximum achievable rate. Moreover, we modify the acquisition procedure of sequence to show the possibility of prospective dynamic imaging. The proposed method is capable of reconstructing high quality real time 2D cardiac images with up to 6X acceleration with excellent image quality and minimal latency of only 6ms on a typical workstation.}
}
@inproceedings{ISMRM2018_4096,
annote={ISMRM2018_4096},
pages={4096},
file={ISMRM2018_4096.pdf:ISMRM2018_4096.pdf:PDF},
title={Accelerating cardiac dynamic imaging with video prediction using deep predictive coding networks},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4096.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Xue Feng and Craig H Meyer},
abstract={Deep predictive coding networks based on stacked recurrent convolutional neural network have shown great success in video prediction since they can learn to recognize and analyze the motion patterns of each element from previous frames. In this study we adopted this model to predict future frames in cardiac cine images and used a k-space substitution method to improve the prediction accuracy. It showed promises in accelerating cardiac dynamic imaging.}
}
@inproceedings{ISMRM2018_4097,
annote={ISMRM2018_4097},
pages={4097},
file={ISMRM2018_4097.pdf:ISMRM2018_4097.pdf:PDF},
title={Machine learning algorithms for detection of motion artifacts: a general approach},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4097.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Alessandro Sciarra and Hendrik Mattern and Oliver Speck},
abstract={Despite all the developments to overcome MRI motion artifacts, there are still open questions. When do we need to repeat a scan? Is the image quality sufficient for segmentation or to make a diagnosis? Is the motion correction working properly? Independent of the type of image acquired (structural, diffusion, functional, etc.), machine learning algorithms can detect automatically motion artifacts and provide feedback in real time. In this work different machine learning algorithms have been tested to detect motion artifacts in synthetic and in vivo data.}
}
@inproceedings{ISMRM2018_4098,
annote={ISMRM2018_4098},
pages={4098},
file={ISMRM2018_4098.pdf:ISMRM2018_4098.pdf:PDF},
title={Motion correction in {MRI} using deep learning},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4098.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Patricia M Johnson and Maria Drangova},
abstract={Subject motion in brain MRI remains an unsolved problem. We propose a machine learning approach for motion correction of brain images. Our initial objective is to train a neural network to perform a motion corrected image reconstruction on image data with simulated motion artefacts. Training pairs were generated using an open source MRI data set; a unique motion profile was applied to each 2D image. A deep neural network was developed and trained with over 3000 image pairs. The images predicted by the network, from motion-corrupted k-space, have improved image quality compared to the motion corrupted images.}
}
@inproceedings{ISMRM2018_4099,
annote={ISMRM2018_4099},
pages={4099},
file={ISMRM2018_4099.pdf:ISMRM2018_4099.pdf:PDF},
title={Ultra-High-Resolution Dental {MR} Imaging Using an Ultra-Short-{TE} Sequence with Prospective Motion Correction},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4099.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Xiang Gao and Philipp Amrein and Johannes Fischer and Davide Piccini and Patrick Hucker and Ute Ludwig and Jan-Bernd Hövener and Maxim Zaitsev},
abstract={High-resolution dental MR Imaging with clear boundaries is of interest for clinical applications e.g. for tooth implant planning. Due to the fast signal decay of the dental tissues, 3D ultra-short-TE (3D-UTE) sequences are employed, which combine rapid center-out half-projection readouts with a phyllotaxis ordering on the surface of k-spacesphere. Even though 3D-UTE is relatively robust against subjectmotion, motion artifacts still limit the achievable image quality. In this work, we implement a 3D-UTE sequence with a camera-based prospective motion correction and apply it in an in vivo experiment to achieve motion-free dental imaging with an isotropic resolution of 0.35mm.}
}
@inproceedings{ISMRM2018_4100,
annote={ISMRM2018_4100},
pages={4100},
file={ISMRM2018_4100.pdf:ISMRM2018_4100.pdf:PDF},
title={Motion robust Magnetic Resonance Fingerprinting using Echo-Planar Imaging and intensity based motion correction},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4100.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Mario Wenning and Benedikt Rieger and Lothar R. Schad and Sebastian Weingärtner},
abstract={Quantitative magnetic resonance imaging (MRI) enables the quantification of biomarkers and the detection of tissue changes. Recently, various magnetic resonance fingerprinting (MRF) sequences were proposed to enable simultaneous quantification of T
1 and T
2/T
2*relaxation times. In this study, we demonstrate motion sensitivity of the original MRF and MRF-EPI. Intensity-based image registration is used in six healthy subjects to eliminate motion artifacts in MRF-EPI. The effectiveness is demonstrated by a significant improvement in the Dice coefficient. As the algorithm is independent of patient and slice, it facilitates motion robust acquisition of parameters maps with MRF ready for clinical use.}
}
@inproceedings{ISMRM2018_4101,
annote={ISMRM2018_4101},
pages={4101},
file={ISMRM2018_4101.pdf:ISMRM2018_4101.pdf:PDF},
title={Separation And Quantification Of Head Motion Modes By Pilot Tone Measurements},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4101.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Peter Speier and Bacher Mario and Jan Bollenbeck and Matthias Fenchel and Tobias Kober},
abstract={Pilot Tone Navigation, a new highly integrated electromagnetic navigation method, was applied to characterize head motion in a guided volunteer experiment. Nodding ("yes") and shaking ("no") motion could be separated and quantified by optimizing linear signal combinations from 20 receive channels on fluoroscopically acquired images. These initial results suggest that head motion can be continuously monitored via the regular MRI receive chain without interaction with the acquisition using a single Pilot Tone generator.}
}
@inproceedings{ISMRM2018_4102,
annote={ISMRM2018_4102},
pages={4102},
file={ISMRM2018_4102.pdf:ISMRM2018_4102.pdf:PDF},
title={Novel and Efficient Generation of Diffeomorphic Motion Phantom},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4102.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Xia Zhu and Dipanjan Sengupta and Theodore L Willke and Andrew Beers and Jayashree Kalpathy-Cramer},
abstract={Dealing with motion artifacts is a fundamental preprocessing step in magnetic resonance imaging (MRI). In this work, we present three novel methods to generate MRI phantoms for diffeomorphic motion which can be used to validate motion correction algorithms. Previous research efforts for diffeomorphic motion generation, employ a brute force approach in which random pixel/voxel displacements are repeatedly generated until a topologically valid displacement is found. Such methods are not only time consuming but also doesn’t guarantee a valid displacement. Our approach algorithmically ensures that the topological properties are always maintained resulting in guaranteed diffeomorphic motion with much faster runtime.
}
}
@inproceedings{ISMRM2018_4103,
annote={ISMRM2018_4103},
pages={4103},
file={ISMRM2018_4103.pdf:ISMRM2018_4103.pdf:PDF},
title={Sliding Motion Corrected Low-rank Plus Sparse Reconstruction for Free-breathing Liver {DCE}-{MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4103.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Wenyuan Qiu and Dongxiao Li and Fan Liu and Xinyu Jin and Thanh D. Nguyen and Martin R. Prince and Yi Wang and Pascal Spincemaille},
abstract={Liver dynamic contrast enhanced MRI (DCE-MRI) requires high spatiotemporal resolution to clearly visualize enhancement patterns. Image reconstruction quality is often compromised due to unavoidable respiratory motion during the long-time acquisition. This abstract presents a novel sliding motion corrected low-rank plus sparse (SMC-LS) reconstruction algorithm for free-breathing liver DCE-MRI. The sliding motion of the liver along the superior-inferior direction is estimated directly from the under-sampled k-space data. Low-rank and sparse regularization are enforced on the sliding motion corrected image reconstructions. Results demonstrated that SMC-LS can substantially reduce motion blurring and preserve more details in free breathing liver DCE-MRI.}
}
@inproceedings{ISMRM2018_4104,
annote={ISMRM2018_4104},
pages={4104},
file={ISMRM2018_4104.pdf:ISMRM2018_4104.pdf:PDF},
title={Self-Calibrated Soft Gating for Respiratory Resolved 3D+Time Lung {ZTE}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4104.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Anne Menini and Peng Lai and Graeme C McKinnon and Florian Wiesinger},
abstract={3D + Time lung ZTE reconstruction can provide combined anatomical imaging and motion extraction for RTP and PET/MR-type applications. In this work, we propose a soft-gating method for non-Cartesian imaging, via a solver preconditioner, to improve the sharpness and SNR of 4D ZTE. No a priori knowledge is used for the soft gating weights, as they are self-calibrated based on coil-image bin to bin similarities. The proposed soft gating method provides a SNR gain while maintaining resolution.}
}
@inproceedings{ISMRM2018_4105,
annote={ISMRM2018_4105},
pages={4105},
file={ISMRM2018_4105.pdf:ISMRM2018_4105.pdf:PDF},
title={Prospectively Respiratory-Cardiac Double-Triggered Three-Dimensional T2-Weighted Abdominal {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4105.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yuji Iwadate and Atsushi Nozaki and Yoshinobu Nunokawa and Shigeo Okuda and Mitsuharu Miyoshi and Masahiro Jinzaki and Hiroyuki Kabasawa},
abstract={We developed a prospective respiratory-cardiac double-triggering technique with navigator echo and incorporated it into 3D T
2-weighted variable refocusing flip-angle fast spin echo (Cube) for abdominal MRI. The respiratory and cardiac navigator signals synchronized well with the signals from the external devices and resultant double-triggered Cube images had higher sharpness scores of the left liver lobe than the respiratory-triggered Cube images. The double-triggering technique is feasible and can be applied to other applications where both respiratory and cardiac motions are problematic.}
}
@inproceedings{ISMRM2018_4106,
annote={ISMRM2018_4106},
pages={4106},
file={ISMRM2018_4106.pdf:ISMRM2018_4106.pdf:PDF},
title={Improved non-rigid motion suppression for free-breathing {PROPELLER} with adaptively weighted blade combination},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4106.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Hai Luo and Gaojie Zhu and Xiang Zhou and Meining Chen and Chao Wang and Xia Liu and Wei Bian and Ziyue Wu},
abstract={PROPELLER has been applied to suppress respiratory motion for free-breathing abdomen imaging but the results are often unsatisfactory with existing weighting mechanisms. In this study, a novel adaptive weighting method is proposed to maximize the respiratory motion suppression without using a fallible reference blade. First, mutual information is used to measure the motion correlation across different blades. Second, principal components analysis is applied to adaptively reject/keep the acquired data by assigning proper weights to all blades. Our experiments show that the proposed method can provide abdominal images with less blurring and less partial volume artifacts compare to the conventional PROPELLER.}
}
@inproceedings{ISMRM2018_4107,
annote={ISMRM2018_4107},
pages={4107},
file={ISMRM2018_4107.pdf:ISMRM2018_4107.pdf:PDF},
title={Joint Non-rigid Motion and Image {MRI} {SENSE} Reconstruction},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4107.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Javier Royuela-del-Val and Alejandro Godino-Moya and Rosa María Menchón-Lara and Santiago Sanz-Estébanez and Federico Simmross-Wattenberg and Marcos Martín-Fernández and Carlos Alberola-López},
abstract={In this work a method of the reconstruction of magnetic resonance images in the presence of non-rigid motion is presented. A non-rigid deformation model is introduced in the reconstruction problem in order to obtain 1) a motion-free image and 2) a set of non-rigid transformations that describe the motion of the structures being imaged. The method is able to reconstruct the motion information without reconstructing the images in additional motion states avoiding extra computational costs and resulting in a better posed reconstruction problem. Preliminary results for 2D cardiac cine MRI are shown.}
}
@inproceedings{ISMRM2018_4108,
annote={ISMRM2018_4108},
pages={4108},
file={ISMRM2018_4108.pdf:ISMRM2018_4108.pdf:PDF},
title={Tracking Respiratory Motion Throughout Arbitrary {MRI} Sequences via Pilot Tone Navigation},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4108.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={David Rigie and Thomas Vahle and Ryan Brown and Tiejun Zhao and Matthias Fenchel and Peter Speier and Kimberly Jackson and Fernando Boada},
abstract={In this work, we demonstrate a flexible approach to track respiratory motion throughout arbitrary MRI sequences without requiring any additional patient setup time or sequence modification. A reference RF signal, which has previously been referred to as the “pilot tone” (PT), is tracked throughout MR imaging and its amplitude modulation provides information about respiratory motion. Specifically, we demonstrate continuous tracking of respiratory motion throughout multi-echo and multi-shot sequences on a human volunteer via PT navigation.}
}
@inproceedings{ISMRM2018_4109,
annote={ISMRM2018_4109},
pages={4109},
file={ISMRM2018_4109.pdf:ISMRM2018_4109.pdf:PDF},
title={Comparison of three surrogate-based respiratory motion correction methods for 3D high resolution cardiac {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4109.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Juliane Ludwig and Peter Speier and Frank Seifert and Tobias Schaeffter and Christoph Kolbitsch},
abstract={Respiratory motion correction has been proposed to improve scan efficiency and ensure high image quality for 3D cardiac MRI. Nevertheless, these techniques often require dedicated data acquisition and cannot necessarily capture intra-cycle variations of the breathing. Here we compare three different surrogate signals (“pilot tone”, respiratory belt and MR-navigator) for a surrogate-based motion correction approach which provides motion information with high temporal resolution and can be combined with a wide range of different MR acquisition schemes. The temporal stability of these surrogates is assessed and motion correction of a 3D cardiac MR scan is demonstrated.}
}
@inproceedings{ISMRM2018_4110,
annote={ISMRM2018_4110},
pages={4110},
file={ISMRM2018_4110.pdf:ISMRM2018_4110.pdf:PDF},
title={Motion-correction algorithm for free-breathing, fast-heart rate small animal studies on clinical scanners},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4110.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Matthew Tarasek and Jeannette Roberts and Deirdre Cassidy and Thomas Foo and Desmond Yeo and Randall Carter and Brian Bales},
abstract={Small animal scanning methods are common for preclinical efficacy evaluation of contrast agents and naïve animal studies done on clinical scanners are becoming more prevalent. Unfortunately, scanning small animals on large-bore clinical scanners creates several challenges such as motion effects due to organ movement and very fast heart-rates. Here we provide a retrospective motion-correction algorithm for fast-heart-rate/free-breathing small animals based on diaphragm tracking. Results show a ten-fold reduction in baseline contrast region signal uncertainty and significant accuracy improvement of pharmacokinetic time-constant estimation.}
}
@inproceedings{ISMRM2018_4111,
annote={ISMRM2018_4111},
pages={4111},
file={ISMRM2018_4111.pdf:ISMRM2018_4111.pdf:PDF},
title={Atlas-based breathing motion correction for dynamic lung Xe{MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4111.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={ADAM SZMUL and Bartlomiej Papiez and Ozkan Doganay and Fergus Gleeson and Daniel Bulte and Julia A. Schnabel and Vicente Grau},
abstract={In this work we propose a framework to compensate for the breathing motion for dynamic lung XeMRI (DXeV), aligning images from different breathing phases and therefore increasing the accuracy of the ventilation analysis process. We build a lung atlas, to delineate a plausible shape of the lungs in the ventilation images, which is further used to co-register all ventilation volumes in the sequence to the reference lung atlas. After applying the proposed breathing motion correction method, the tidal breathing motion has been largely compensated and all masks of ventilation volumes correspond to each other spatially.}
}
@inproceedings{ISMRM2018_4112,
annote={ISMRM2018_4112},
pages={4112},
file={ISMRM2018_4112.pdf:ISMRM2018_4112.pdf:PDF},
title={Implementation of a control system for prospective respiratory motion correction during Cardiovascular {MR} imaging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4112.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Stephen G Jermy and Ali Alhamud and Ian H Burger and Ntobeko A B Ntusi and Ernesta M Meintjes},
abstract={Navigated free-breathing techniques are commonly used during cardiovascular MR (CMR) acquisitions when breath-holding techniques are not a viable option. Navigated free-breathing techniques with acceptance windows suffer from much longer scan times. A control system using an adaptive Kalman filter was developed to continuously update the slice position throughout the imaging segment during free-breathing CMR, allowing the acquisition to continue throughout the respiratory cycle, regardless of diaphragm position, thereby improving respiratory efficiency and reducing scan times.}
}
@inproceedings{ISMRM2018_4113,
annote={ISMRM2018_4113},
pages={4113},
file={ISMRM2018_4113.pdf:ISMRM2018_4113.pdf:PDF},
title={Motion Correction based on Z-spectral Consistency for {APT}w/{CEST}w {MRI} Applications in Body Oncology},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4113.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jochen Keupp and Elwin de Weerdt},
abstract={CESTw imaging in body areas with significant physiological motion is strongly hampered because of the inherent motion sensitivity of this MRI technique. In particular, slow physiological motion in the abdomen, e.g. peristaltic motion or bladder filling may lead to Z-spectral inconsistency and artifacts in CESTw images. Here, a method is introduced which analyzes Z-spectral consistency to mask CESTw image areas affected by motion. The technique is successfully demonstrated on a volunteer example in liver CESTw MRI, indicating a future application in body oncology.}
}
@inproceedings{ISMRM2018_4114,
annote={ISMRM2018_4114},
pages={4114},
file={ISMRM2018_4114.pdf:ISMRM2018_4114.pdf:PDF},
title={Automatic Motion Artifact Detection as Scan-aided Tool in an Autonomous {MRI} Environment},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4114.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Wenwen Jiang and Okai Addy and William Overall and Bob Hu and Juan Santos},
abstract={Motion artifacts in MRI can be confused with pathology and render the scans not diagnosable. Ideally during examination, scan operators should identify these artifacts immediately and reacquire the scan. But it can be challenging to do so in a clinical time-constraint workflow. Motion artifacts are especially difficult to identify accurately, as they come in a wide variety. Here, we propose an autonomous scan control framework, based on deep learning, to detect motion artifacts immediately after reconstruction. The deep learning model was integrated into a real-time imaging system and enabled an interactive scanning pipeline.}
}
@inproceedings{ISMRM2018_4115,
annote={ISMRM2018_4115},
pages={4115},
file={ISMRM2018_4115.pdf:ISMRM2018_4115.pdf:PDF},
title={{MR}-assisted {PET} reconstruction in the presence of respiratory motion: A phantom study},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4115.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Cihat Eldeniz and H. Michael Gach and Richard Laforest and Hongyu An},
abstract={Simultaneous PET/MR provides an unprecedented opportunity for motion correction. We aimed at developing an integrated MR-assisted PET motion correction method which would allow accurate PET quantification in the presence of respiratory motion. In this study, we evaluated the impact of motion correction on lesions of various sizes by using a deformable motion phantom. A static scan was used as the ground truth for PET activity. The combined MR and PET motion correction recovered the activity from 55\% to >97\% of the static scan activity.}
}
@inproceedings{ISMRM2018_4116,
annote={ISMRM2018_4116},
pages={4116},
file={ISMRM2018_4116.pdf:ISMRM2018_4116.pdf:PDF},
title={{MR}/{PET} motion correction using deep learning},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4116.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yasheng Chen and Cihat Eldeniz and Richard Laforest and Hongyu An},
abstract={In abdominal imaging, the simultaneous acquisition of MR and PET provides a unique opportunity to take advantage of MR (which has high spatial and temporal resolution) to resolve the respiratory motion artefacts in PET. But this motion correction scheme requires MR motion scans during the whole PET session. To improve the imaging efficiency, we use simultaneously acquired MR/PET signal to train a PET re-binning motion correction classifier, which can be deployed to correct the motion in the PET scans without concurrently acquired MR motion detection. We have demonstrated the feasibility of this online motion correction scheme with a phantom study.}
}
@inproceedings{ISMRM2018_4117,
annote={ISMRM2018_4117},
pages={4117},
file={ISMRM2018_4117.pdf:ISMRM2018_4117.pdf:PDF},
title={{CS}+M: A Simultaneous Reconstruction and Motion Estimation Approach for Improving Undersampled {MRI} Reconstruction.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4117.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Angelica I. Aviles-Rivero and Guy B. Williams and Martin J. Graves and Carola-Bibiane Schönlieb},
abstract={Current research in MRI is based on using CS implications to reconstruct high-quality images from a subset of $k$-space data acquired in an incoherent manner. In this work, we introduce a mathematical framework for improving undersampled MRI data reconstruction, which we call CS+M, where M stands for motion. The significance here and unlike existing solutions is that by modeling explicitly and simultaneously the inherent complex motion patterns, given by physiological or involuntary motion, in a CS setting, synergies in a complex variational problem are created. These synergies have clinical potentials in terms of improving image quality while reducing motion artifacts.}
}
@inproceedings{ISMRM2018_4118,
annote={ISMRM2018_4118},
pages={4118},
file={ISMRM2018_4118.pdf:ISMRM2018_4118.pdf:PDF},
title={An alternating algorithm for dynamic cardiac {MRI} reconstruction and motion estimation},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4118.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ningning Zhao and Daniel O'Connor and Dan Ruan and Ke Sheng},
abstract={This work deals with the problem of dynamic MRI reconstruction and motion estimation jointly. Specifically, a multi-scale affine optical flow model is incorporated into the compressed sensing framework. Simulation results demonstrate the efficiency of the proposed algorithm in image reconstruction and motion estimation against the standard CS based method for MRI reconstruction.}
}
@inproceedings{ISMRM2018_4119,
annote={ISMRM2018_4119},
pages={4119},
file={ISMRM2018_4119.pdf:ISMRM2018_4119.pdf:PDF},
title={3D Motion Estimation and Correction of Motion in Sequential Slices of Kidney Diffusion-Weighted {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4119.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Sila Kurugol and Bahram Marami and Onur Afacan and Simon K. Warfield and Ali Gholipour},
abstract={In this paper we introduced a motion-compensated model estimation technique for renal DW-MRI. The technique has two main components: 1) we adapted an approach based on robust state estimation, which was recently utilized to solve slice-based motion estimation, to track physiological motion (including respiratory motion); 2) we used weighted least squares to estimate diffusion tensor model and calculate diffusion parameters from motion-compensated data. Overall, our method achieved the highest FA values in the medulla, compared to no motion correction and volume to volume registration which resulted in reduced FA values, artifacts and blurrier FA, MD and AD maps.}
}
@inproceedings{ISMRM2018_4120,
annote={ISMRM2018_4120},
pages={4120},
file={ISMRM2018_4120.pdf:ISMRM2018_4120.pdf:PDF},
title={Correction of Slice-Specific Nyquist Ghost Artifact for Simultaneous Multi-Slice {EPI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4120.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Uten Yarach and Oliver Speck},
abstract={The slice-specific ghosting artifact has been challenging for SMS-EPI. A standard 1D-based phase correction usually leads to increased residual ghosting artifacts in case of subject motion or eddy current variations at different time points. In this study, we propose a dynamic 2D slice-specific phase correction to address the slice-specific phase error. This correction scheme does not require additional time for acquiring 2D phase difference scans. It is a combination between slice-GRAPPA and model-based framework. The result shows that the ghost-to-signal ratios for MB3Ry2 in human brain obtained by the proposed and vendor-provided reconstruction were 1.37\% and 2.66\%, respectively.}
}
@inproceedings{ISMRM2018_4121,
annote={ISMRM2018_4121},
pages={4121},
file={ISMRM2018_4121.pdf:ISMRM2018_4121.pdf:PDF},
title={Nyquist Artifact Correction for Multi-band and Multi-shot {EPI} Using Multiplexed Sensitivity Encoding ({MUSE}) - A Self-reference 2D Phase Correction Method},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4121.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Xiaoxi Liu and Di Cui and Edward S. Hui and Queenie Chan and Nan-Kuei Chen and Hing-Chiu Chang},
abstract={Echo planar imaging (EPI) suffers from Nyquist artifact that is typically corrected by using 1D phase correction with reference scan. In oblique-plane acquisition, 2D phase corrected is warranted to effectively reduce Nyquist artifact. However, Nyquist artifact correction is challenging in the case of multi-band EPI due to the presence of slice-dependent phase error. In this study, we aim to develop a self-reference 2D phase correction method to eliminate the Nyquist artifact in multi-band multi-shot EPI data, which utilizes the recently developed multiplexed sensitivity encoding (MUSE) reconstruction algorithm.}
}
@inproceedings{ISMRM2018_4122,
annote={ISMRM2018_4122},
pages={4122},
file={ISMRM2018_4122.pdf:ISMRM2018_4122.pdf:PDF},
title={Removal of Pseudo-lesion Artifact in Diffusion-Weighted Echo-Planar Imaging Using Virtual Coil Acquisition and Multiplexed Sensitivity Encoding ({MUSE})},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4122.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Xiaoxi Liu and Edward S. Hui and Hing-Chiu Chang},
abstract={In routine brain DW-EPI with SENSE, the pseudo-lesion artifact due to residual aliasing of eyeball has been previously reported. We have found that the incidence of pseudo-lesion artifact was over 50\% when performing double-oblique imaging on stroke patients. The possible cause is highly likely related to inference between residual Nyquist ghost and unfolding process in SENSE reconstruction. In this study, we propose a self-reference method to effectively remove pseudo-lesion artifact in double-oblique DW-EPI using virtual coil acquisition and multiplexed sensitivity encoding (MUSE). Our proposed method reveals higher image quality, better SNR performance and lower artifact level than conventional SENSE reconstruction.}
}
@inproceedings{ISMRM2018_4123,
annote={ISMRM2018_4123},
pages={4123},
file={ISMRM2018_4123.pdf:ISMRM2018_4123.pdf:PDF},
title={Characterization and suppression of stripe artifact in velocity-selective magnetization-prepared unenhanced {MR} angiography},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4123.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Taehoon Shin and Qin Qin},
abstract={While velocity-selective magnetization-prepared MR angiography (VS-MRA) has shown great promise for diverse arterial territories, artifactual stripes often occur in resultant angiograms. We investigate the formation of the stripe artifact using extended phase graph analysis and show that the stripes contain not only the fundamental frequency determined by the area of VS unipolar gradient but higher-order components with multiples of the fundamental frequency. Based on this finding, we propose and test efficient strategies for suppression of the artifact in a phantom and healthy human subjects.}
}
@inproceedings{ISMRM2018_4124,
annote={ISMRM2018_4124},
pages={4124},
file={ISMRM2018_4124.pdf:ISMRM2018_4124.pdf:PDF},
title={Metal artifact reduction in {MRI}-based radiation therapy},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4124.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={H Michael Gach and Stacie L Mackey and Mo Kadbi and Jacqueline E Zoberi and Jose Garcia-Ramirez and Yuan (James) Rao and S Murty Goddu and Perry W Grigsby and Hiram A Gay and Christina I Tsien and Jiayi Huang and Jeff M Michalski},
abstract={A large percentage of patients receiving MRI simulations for radiotherapy treatment planning have metal in their bodies. Often the metal is in or near the target or organs at risk. Metal creates susceptibility artifacts that can saturate the tissue signal and distort the tissue geometry. In this case report, examples of the benefits of metal artifact reduction using slice encoding for metal artifact correction (SEMAC) are presented for patients scanned at 1.5 T. Critical regions that were obscured by artifact were restored using SEMAC, thus allowing MRI-based treatment planning.}
}
@inproceedings{ISMRM2018_4125,
annote={ISMRM2018_4125},
pages={4125},
file={ISMRM2018_4125.pdf:ISMRM2018_4125.pdf:PDF},
title={Robust Virtual Coil {SAKE} with Automatic Rank Thresholding for Removal of {EPI} Ghost Artifacts},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4125.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Zhenda Xu and Mengye Lyu and Yilong Liu and Markus Barth and Ed X. Wu},
abstract={Ghost artifacts in EPI can arise from phase error between positive- and negative-echo and inter-shot phase error. Virtual coil SAKE (VC-SAKE) can be used to eliminate these phase errors simultaneously, but its performance relies on selection of parameters. In particular, proper rank thresholding is extremely important. In this study, we proposed to automatically determine the optimal rank threshold by minimizing the image entropy and evaluated its performance with various datasets from different scanner systems.}
}
@inproceedings{ISMRM2018_4126,
annote={ISMRM2018_4126},
pages={4126},
file={ISMRM2018_4126.pdf:ISMRM2018_4126.pdf:PDF},
title={Clinical Evaluation of Pile-up and Ripple Artifact Suppression Near Metal by Alternating Gradients},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4126.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Xinwei Shi and Kathryn Stevens and Brian Hargreaves},
abstract={Multi-Spectral Imaging techniques have been shown to significantly reduce metal-induced artifacts. However, they often suffer from pile-up/ripple artifacts near metal, where metal-induced-off-resonance gradients “cancel” the frequency-encoding gradient. We have previously proposed a method to reduce these artifacts by combining two acquisitions with alternating-sign readout and slice-select gradients. Here we demonstrate that the alternating-gradient method is compatible with robust PCA, which provides 2-fold acceleration beyond parallel imaging and half-Fourier acquisition to compensate for the additional acquisition. Our study shows that the alternating-gradient method can significantly reduce pile-up/ripple artifacts in volunteers with hip and knee arthroplasties and provides additional diagnostic advantages compared to the standard sequence.
}
}
@inproceedings{ISMRM2018_4127,
annote={ISMRM2018_4127},
pages={4127},
file={ISMRM2018_4127.pdf:ISMRM2018_4127.pdf:PDF},
title={f{MRI} at 7 Tesla with 0.5mm Isotropic Resolution and Full Field of View},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4127.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Patrick Liebig and Robin Martin Heidemann and Bernhard Hensel and Yuehui Tao and Wei Liu and David Porter},
abstract={fMRI protocols at ultra-high field typically use pixel sizes below 1mm. With single-shot EPI, this results in a prolonged readout train relative to the T2* decay time, resulting in image blurring and a limit to the true resolution that can be achieved. This effect can be mitigated by using multi-shot EPI to reduce the echo-train length, but this is associated with a reduction in temporal SNR. Previous work demonstrated a less severe reduction in temporal stability with readout-segmented EPI than with interleaved EPI. This study investigates the application of readout-segmented EPI to ultra-high resolution fMRI of the motor cortex.}
}
@inproceedings{ISMRM2018_4128,
annote={ISMRM2018_4128},
pages={4128},
file={ISMRM2018_4128.pdf:ISMRM2018_4128.pdf:PDF},
title={A {CAIPIRINHA}-based approach to the referenceless reconstruction of high-definition {SPEN} images with simultaneous multislice},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4128.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Gilad Liberman and Samuel F Cousin and Eddy Solomon and Lucio Frydman},
abstract={Spatiotemporal Encoding (SPEN) is an ultrafast imaging technique where the low-bandwidth axis is rasterized in a joint spatial/k-domain. SPEN benefits from increased robustness to inhomogeneities, folding-free reconstruction of subsampled data and an ability to combine multiple interleaved or signal averaging scans in a referenceless fashion. SPEN’s relatively high SAR, however, complicates its volumetric uses. Here we show how this can be solved by merging a controlled aliasing for parallel imaging (CAIPIRINHA) protocol involving phase-cycling of multi-banded excitation pulses in independent scans, so as to enable a referenceless reconstruction of interleaved multislice acquisitions delivering high in-plane definition and excellent inter-slice decoupling.}
}
@inproceedings{ISMRM2018_4129,
annote={ISMRM2018_4129},
pages={4129},
file={ISMRM2018_4129.pdf:ISMRM2018_4129.pdf:PDF},
title={Constrained Lossy Compression for {MR} Raw Data Transmission},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4129.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Matthew Restivo and Adrienne Campbell-Washburn and Peter Kellman and Hui Xue and Rajiv Ramasawmy and Michael Hansen},
abstract={Computationally intensive image reconstruction algorithms can be made accessible to the diagnostic workflow by streaming data to remote workstations in real-time. Due to bandwidth constraints, data compression is an important tool to ensure that network transmission is not a bottleneck. However, since image quality losses are unacceptable for clinical MRI, it is important to constrain any compression losses below the thermal noise. Here we propose a framework for online data compression based on constraining SNR loss using a custom-built compression library. Greater than 5-fold data reduction was achieved by accepting a negligible SNR loss.}
}
@inproceedings{ISMRM2018_4130,
annote={ISMRM2018_4130},
pages={4130},
file={ISMRM2018_4130.pdf:ISMRM2018_4130.pdf:PDF},
title={Anisotropic Field-of-Views in 3D Golden Angle Radial Imaging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4130.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Guruprasad Krishnamoorthy and Jouke Smink and Marc Kouwenhoven and Marcel Breeuwer},
abstract={3D Golden angle Radial sequence (3D-GA
rad) permits reconstruction with varying temporal / spatial resolution from the same dataset. It is less sensitive to motion, flow artifacts and supports ultra-short echo times. It supports self-gated retrospective motion correction techniques. One of the limitations of the current implementations of 3D-GA
rad is, it only supports isotropic field-of-view (FOV), which leads to redundant sampling and increased scan time when the imaging volume has anisotropic dimensions. In this work, we have developed a method based on the work by Larson et al., to support anisotropic FOV with different FOV-shapes for 3D-GA
rad.}
}
@inproceedings{ISMRM2018_4131,
annote={ISMRM2018_4131},
pages={4131},
file={ISMRM2018_4131.pdf:ISMRM2018_4131.pdf:PDF},
title={A quadrature filter approach to diffusion weighted imaging with application in pore size estimation},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4131.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Hans Knutsson and Filip Szczepankiewicz and Cem Yolcu and Magnus Herberthson and Evren Özarslan and Markus Nilsson and Carl-Fredrik Westin},
abstract={We present a novel approach to gradient waveform design for diffusion weighted MRI. The approach is founded on the temporal frequency domain formulation of the signal attenuation. The objective is to obtain a set of circularly polarized oscillating gradient waveforms that are optimal in terms of b-value, frequency selectivity and in-plane rotational invariance. A new pore size estimation algorithm is presented. We show phantom and in vivo results based on MRI scans using an opimized waveform set.}
}
@inproceedings{ISMRM2018_4132,
annote={ISMRM2018_4132},
pages={4132},
file={ISMRM2018_4132.pdf:ISMRM2018_4132.pdf:PDF},
title={In vivo O-space Turbo Spin Echo Imaging with New Reconstruction Algorithm},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4132.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Nadine Luedicke Dispenza and Hemant Tagare and R. Todd Constable and Galiana Gigi},
abstract={We report the first in-vivo T2 weighted O-space TSE images and demonstrate that a single TSE dataset can generate T2w images for any of the echo times while still tolerating further undersampling from parallel imaging. In addition to reconstructions based on a refinement of a previously introduced filtering algorithm, we introduce a more general and rigorous reconstruction approach that exploits the geometric relationship between images in the T2w series. The proposed reconstruction algorithm reduces T2 blur and improves contrast agreement to Cartesian TSE images.}
}
@inproceedings{ISMRM2018_4133,
annote={ISMRM2018_4133},
pages={4133},
file={ISMRM2018_4133.pdf:ISMRM2018_4133.pdf:PDF},
title={Enhancing Spatial-Temporal Resolution in Simultaneous Multi-Slab Echo Volumar Imaging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4133.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Kishore Vakamudi and Steen Moeller and Sudhir Ramanna and Akio Yoshimoto and Essa Yacoub and Ricardo Otazo and Alam Abbas Syed and Stefan Posse},
abstract={We develop multi-band echo-volumar-imaging (MB-EVI) by combining multi-slab encoding with EVI to investigate BOLD sensitivity, resting-state connectivity in different frequency bands and spatial-temporal resolution limits. We also study the effect of compressed sensing (CS) reconstruction on fMRI sensitivity. Mapping of major resting-state networks with 3mm
3 voxel size was feasible in multiple frequency bands. High spatial resolution (2mm
3) improved delineation of neuroanatomy and enabled sensitive mapping task-based activation. CS with 2.4-fold undersampling showed negligible loss in image quality and moderate region-specific losses in BOLD sensitivity. MB-EVI provides flexibility for maximizing spatial-temporal resolution, volume-coverage and BOLD-sensitivity for mapping task-activation and functional connectivity.}
}
@inproceedings{ISMRM2018_4134,
annote={ISMRM2018_4134},
pages={4134},
file={ISMRM2018_4134.pdf:ISMRM2018_4134.pdf:PDF},
title={Respiration resolved imaging using continuous steady state multiband excitation with linear frequency sweeps},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4134.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Laurence H Jackson and Anthony N Price and Jana Hutter and Lucilio Cordero-Grande and Alison Ho and Paddy J Slator and Ana Dos Santo Gomes and Joshua F.P. van Amerom and Maria Murgasova and Laura McCabe and Mary A Rutherford and Joseph V Hajnal},
abstract={Free-breathing abdominal MRI is challenging due to the unpredictable and complex 3D deformation caused by respiration. We present a novel acquisition where short TR single-band or multiband slice acquisitions are swept smoothly across the anatomy of interest while preserving steady state conditions. This is achieved by adding a frequency offset to successive RF pulses shifting the excited slice by fraction of slice thickness for each acquired k-space. This creates a highly efficient acquisition with high redundancy in respiration. A method is presented to produce 4D respiration-resolved volumes from this data and examples of human placenta and kidney are presented.}
}
@inproceedings{ISMRM2018_4135,
annote={ISMRM2018_4135},
pages={4135},
file={ISMRM2018_4135.pdf:ISMRM2018_4135.pdf:PDF},
title={{SWI}+: A robust artifact-free {SWI} procedure with improved contrast},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4135.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yongquan Ye and Jinguang Zong and Jingyuan Lyu and Weiguo Zhang},
abstract={A robust image reconstruction and processing strategy to achieve minimal susceptibility artifact for SWI is developed and demonstrated. With a multi-echo GRE data acquisition and a newly developed robust rapid phase unwrapping algorithm, an enhanced version of SWI imaging procedure, namely SWI+, is developed to address the pitfalls in classic SWI, which collects only one echo and simply employs high pass filtering on phase images.}
}
@inproceedings{ISMRM2018_4136,
annote={ISMRM2018_4136},
pages={4136},
file={ISMRM2018_4136.pdf:ISMRM2018_4136.pdf:PDF},
title={Reducing eddy currents in radial cardiovascular {MRI} using tiny 3D golden-angle},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4136.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Alexander Fyrdahl and Karen Holst and Martin Ugander and Andreas Sigfridsson},
abstract={Three-dimensional double golden-angle radial imaging has shown great potential in free-breathing whole-heart cardiac cine imaging using data binning and respiratory resolved cardiac imaging. However, the original golden-angle trajectory involves large jumps in k-space, which leads to eddy current artifacts in bSSFP imaging. For successful binned cardiac imaging, two conditions must be fulfilled; first, the trajectory should provide high k-space uniformity and second, the trajectory should avoid eddy current induced degradation of image uniformity. The purpose of this work was to develop a double golden-angle radial trajectory that fulfills both of these conditions.}
}
@inproceedings{ISMRM2018_4137,
annote={ISMRM2018_4137},
pages={4137},
file={ISMRM2018_4137.pdf:ISMRM2018_4137.pdf:PDF},
title={Model-based Reconstruction with Automatic Scaling for Real-Time Phase-Contrast Flow {MRI} with Complementary Sets of Radial Spokes},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4137.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Zhengguo Tan and Jost M Kollmeier and Arun A Joseph and Oleksandr Kalentev and Dirk Voit and Klaus-Dietmar Merboldt and Thorsten Hohage and Jens Frahm},
abstract={Real-time phase-contrast flow MRI is extended from sequential acquisitions of flow-compensated and flow-encoded data with the same set of radial spokes to interleaved acquisitions with different radial spokes oriented by a small Golden angle, thereby improving spatial accuracy and reducing streaking artifacts. To apply model-based reconstructions for this sampling scheme, an automatic scaling of unknowns is proposed, which is capable of balancing partial derivatives and regularizations during the iterative nonlinear inversion.}
}
@inproceedings{ISMRM2018_4138,
annote={ISMRM2018_4138},
pages={4138},
file={ISMRM2018_4138.pdf:ISMRM2018_4138.pdf:PDF},
title={Hybrid O-Space and {FRONSAC} Imaging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4138.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Haifeng Wang and Yuchou Chang and Dong Liang},
abstract={Nonlinear spatial encoding magnetic (SEM) fields can accelerate data acquisitions and improve the imaging quality. In this work, the O-Space and FRONSAC imaging are combined into a hybrid nonlinear spatial encoding approach with dynamic nonlinear gradients. The preliminary experiment of phase mapping shows that the proposed method can be implemented in the current O-Space system. Simulations based on the preliminary experiment demonstrate that this approach can accelerate data acquisitions and reduce artefacts caused by highly undersampling acquisitions.}
}
@inproceedings{ISMRM2018_4139,
annote={ISMRM2018_4139},
pages={4139},
file={ISMRM2018_4139.pdf:ISMRM2018_4139.pdf:PDF},
title={{MR} Image Reconstruction via Denoising ({MR}-{RED})},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4139.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Adam Rich and Rizwan Ahmad},
abstract={In this work, the feasibility of employing denoising to recover MR images from undersampled data is demonstrated. By embedding denoisers into the Laplacian-based regularization functional and solving the resulting optimization problem, state-of-the-art results are achieved. Performance of several denoisers and compressed sensing methods is compared in four cardiac MRI datasets. We show that denoising-based reconstruction can outperform soft-thresholding-based algorithms in terms of normalized MSE.}
}
@inproceedings{ISMRM2018_4140,
annote={ISMRM2018_4140},
pages={4140},
file={ISMRM2018_4140.pdf:ISMRM2018_4140.pdf:PDF},
title={Optimizing Cartesian compressed sensing for ultra-high resolution Time of Flight angiography},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4140.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Hendrik Mattern and Oliver Speck},
abstract={Ultra-high resolution Time of Flight (ToF) angiography requires long scan times. Compressed sensing (CS) can reduce the scan time but requires pseudo-random sampling and may blur image details. We present a framework to create Cartesian pseudo-random sampling patterns from any given probability density function and to evaluate quantitatively vessel depiction with CS reconstruction. Results from 0.30 mm and 0.15 mm isotropic ToF data show that moderate acceleration with CS can reduce the scan time considerably while providing vessel depiction similar to the non-accelerated reference.}
}
@inproceedings{ISMRM2018_4141,
annote={ISMRM2018_4141},
pages={4141},
file={ISMRM2018_4141.pdf:ISMRM2018_4141.pdf:PDF},
title={Improved Parallel Echo-Planar Imaging ({EPI}) with Ghost Removal and Distortion Correction},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4141.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yuan Zheng and Yu Ding and Xiaodong Ma and Weiguo Zhang},
abstract={We have developed a procedure for reconstructing high-quality EPI images with parallel imaging and presented both in-vitro and in-vivo results. Interleaved EPI and the PLACE technique are used to generate coil sensitivity maps (CSM) and a distortion map. These maps do not suffer from ghosting and match the distortion of the imaging data. The CSM are used in the PEC-SENSE reconstruction to generate images with significantly reduced ghosting artifacts. Geometric distortions are subsequently corrected using the distortion map. This technique can be used to improve the image quality of many EPI applications, such as diffusion imaging, when parallel imaging is involved.}
}
@inproceedings{ISMRM2018_4142,
annote={ISMRM2018_4142},
pages={4142},
file={ISMRM2018_4142.pdf:ISMRM2018_4142.pdf:PDF},
title={Efficient $k$-space coverage using a 3D accelerated low-discrepancy trajectory},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4142.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Tobias Speidel and Volker Rasche},
abstract={Acquiring three-dimensional (3D) images in MRI is a time consuming process. The overall duration of acquiring a Nyquist sampled 3D dataset can be significantly shortened by enhancing the efficiency of $k$-space sampling. This can be achieved by accelerating each $k$-space read-out and by additionally increasing the coverage of $k$-space for every trajectory interleave. In this work, we present a 3D $k$-space trajectory that is highly accelerated in terms of $k$-space velocity that leads to a low-discrepant coverage of suchlike using a considerably reduced number of read-outs.}
}
@inproceedings{ISMRM2018_4143,
annote={ISMRM2018_4143},
pages={4143},
file={ISMRM2018_4143.pdf:ISMRM2018_4143.pdf:PDF},
title={3D Golden Angle Stack-of-Stars with Anisotropic Field-of-View},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4143.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Joao Tourais and Guruprasad Krishnamoorthy and Marc Kouwenhoven and Jouke Smink and Marcel Breeuwer},
abstract={Radial sampling techniques are often used in dynamic MRI because they are robust to flow and motion, support short echo times and have a diffuse aliasing pattern. However, standard implementations of radial imaging do not support in-plane anisotropic FOV, which leads to sampling redundancy when the object being imaged has anisotropic in-plane dimensions (e.g. abdomen, chest, spine, leg, etc.). In this work we demonstrate the feasibility of 3D golden angle stack-of-stars acquisition with an in-plane anisotropic FOV in abdominal acquisitions.}
}
@inproceedings{ISMRM2018_4144,
annote={ISMRM2018_4144},
pages={4144},
file={ISMRM2018_4144.pdf:ISMRM2018_4144.pdf:PDF},
title={Asymmetric-echo-based Ultrashort Echo-time ({ASE}-{UTE}) Imaging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4144.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jinil Park and Jeongtaek Lee and Jang-Yeon Park},
abstract={The first 3D-UTE sequence used FID acquisition techniques using ramp sampling to minimize TE, but defining the center of k-space precisely was a difficult problem (true-k
0). In case of echo acquisition containing echo peaks, it is better to define true-k0 than FID acquisition although true-k
0 problem still exists because echo peaks often do not agree with true-k
0 due to the echo shifts caused by system imperfections such as gradient delays and eddy currents. Here, we propose an asymmetric-echo-based 3D-UTE (ASE-UTE) sequence where echo peaks are acquired on the ramp.}
}
@inproceedings{ISMRM2018_4145,
annote={ISMRM2018_4145},
pages={4145},
file={ISMRM2018_4145.pdf:ISMRM2018_4145.pdf:PDF},
title={Simultaneous Multi-slice Ultra-short Echo Time Imaging Using {POMP} Half Pulses and {CAIPI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4145.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Christoph Alexander Rettenmeier and V. Andrew Stenger},
abstract={Phase offset multi-planar (POMP) encoding is applied in a simultaneous multi-slice (NSMS = 4) excitation scheme using half sinc pulses. In combination with a gradient echo 2D spiral readout trajectory and controlled aliasing in parallel imaging (CAIPI) via a model-based reconstruction a fast ultra-short echo time (UTE) sequence is developed. Sequence details and performance tests on short T2* phantoms are presented.}
}
@inproceedings{ISMRM2018_4146,
annote={ISMRM2018_4146},
pages={4146},
file={ISMRM2018_4146.pdf:ISMRM2018_4146.pdf:PDF},
title={Improvement of 2D-multi-slice, multi-shot Cartesian T2-weighted {TSE} using golden angle shot reordering},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4146.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yuki Furukawa and Takashige Yoshida and Masami Yoneyama and Kouhei Yuda and Mariko Okura and Nobuo Kawauchi},
abstract={2D multi-slice, multi-shot Cartesian TSE sequence is frequently used for routine MRI but it is sensitive to motion. We evaluated the feasibility of golden angle shot reordering for 2D-multi-shot TSE with 60 patients. Golden angle shot reordering reduced effectively ghost artifacts by randomly filling in each segment of Cartesian k-space. We demonstrated that golden angle shot reordering intrinsically has a motion robustness without penalty for image quality and scan time. This technique might be useful for all anatomies in routine clinical examination..}
}
@inproceedings{ISMRM2018_4147,
annote={ISMRM2018_4147},
pages={4147},
file={ISMRM2018_4147.pdf:ISMRM2018_4147.pdf:PDF},
title={{APIR}4{EMC}: Autocalibrated Parallel Imaging Reconstruction for Extended Multi-Contrast Imaging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4147.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Chaoping Zhang and Alexandra Cristobal-Huerta and Juan Antonio Hernandez-Tamames and Stefan Klein and Dirk H.J. Poot},
abstract={Multi-contrast images of the same region are routinely acquired in clinical MRI. This abstract proposes a fast reconstruction method for multi-contrast imaging: Autocalibrated Parallel Imaging Reconstruction for Extended Multi-Contrast (APIR4EMC). Unlike conventional parallel imaging (GRAPPA) which reconstructs the image for individual contrast, APIR4EMC additionally includes the inter-contrast signals in the prediction of unsampled positions in the k-space of each contrast and simultaneously reconstructs images for all contrasts. Experiments show significant improvement of APIR4EMC compared to conventional parallel imaging in terms of artifacts and SNR.}
}
@inproceedings{ISMRM2018_4148,
annote={ISMRM2018_4148},
pages={4148},
file={ISMRM2018_4148.pdf:ISMRM2018_4148.pdf:PDF},
title={Wind Out-In Dual-Echo Yarn-Ball with Application to Knee Imaging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4148.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Robert W. Stobbe and Christian Beaulieu},
abstract={3D centre-out Yarn-Ball k-space acquisition is implemented in a wind-out/wind-in dual-echo format for the first time. As with standard 3D-Radial acquisition this technique facilitates short (first ‘echo’) TE with utility for imaging tissues with short T
2*. However, the advantage of centre-out Yarn-Ball is much greater k-space sampling efficiency than 3D-Radial. Smooth variation from wind-out to wind-in minimizes potential errors in k-space trajectory evolution as a result of eddy-currents. Spoiled-steady-state dual-echo 3D Yarn-Ball images with 0.7x0.7x0.7 mm
3 voxels were acquired from the knee of a healthy volunteer in 6 minutes and the difference image shows ligament and meniscus conspicuity.}
}
@inproceedings{ISMRM2018_4149,
annote={ISMRM2018_4149},
pages={4149},
file={ISMRM2018_4149.pdf:ISMRM2018_4149.pdf:PDF},
title={A rapid 3D spiral readout with uniform sampling density and smooth T2* weighting},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4149.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Maria Engel and Lars Kasper and Christoph Barmet and Thomas Schmid and Klaas Paul Pruessmann},
abstract={A stack of disks trajectory for fast 3D acquisitions with long readouts is introduced and compared to interleaved stack of spiral and Yarn-ball trajectories. Isotropic 1.6 mm whole-brain coverage is achieved in less than a second.}
}
@inproceedings{ISMRM2018_4150,
annote={ISMRM2018_4150},
pages={4150},
file={ISMRM2018_4150.pdf:ISMRM2018_4150.pdf:PDF},
title={Redesigned Cones Trajectory based on Discretization of Cones Coordinate},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4150.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Kwang Eun Jang and Dwight G. Nishimura and Shreyas S. Vasanawala},
abstract={We propose a new non-Cartesian sampling scheme based on a 3D cones k-space trajectory. The design framework uses a cones coordinate system that uniquely represents a point in 3D k-space with a rotation of a spiral that resides on a conic surface. The new trajectory is obtained by discretizing the proposed coordinate system. Incorporation of a variable-density spiral improves the sampling efficiency. Simulations and phantom studies demonstrate the improved efficiency of the new scheme compared to the conventional cones design.
}
}
@inproceedings{ISMRM2018_4151,
annote={ISMRM2018_4151},
pages={4151},
file={ISMRM2018_4151.pdf:ISMRM2018_4151.pdf:PDF},
title={Motion Prediction using a Multi-Rate Kalman Filter with Golden Angle Radial Acquisition for Real-Time {MRI}-Guided Interventions},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4151.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Xinzhou Li and Samantha Mikaiel and Holden H. Wu},
abstract={Real-time MRI can provide high soft-tissue contrast without ionizing radiation for interventional procedure guidance. To achieve accurate and low-latency tracking of target tissues for decision support and feedback control, this work proposes a motion prediction framework based on a multi-rate Kalman filter and real-time golden-angle radial MRI. The proposed framework leverages the unique sampling pattern of golden-angle radial acquisition to combine image-based with surrogate-based motion tracking. Initial results demonstrate that the proposed framework can achieve significantly reduced error in motion prediction and provide low-latency feedback for real-time MRI guided interventions.}
}
@inproceedings{ISMRM2018_4152,
annote={ISMRM2018_4152},
pages={4152},
file={ISMRM2018_4152.pdf:ISMRM2018_4152.pdf:PDF},
title={Simultaneous 3D Whole-Heart Bright-Blood Visualization of the Coronary Sinus and Heart Anatomy and Black-Blood {PSIR} Quantification of Atrial Wall Thickness for Non-Contrast Enhanced Interventional Planning},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4152.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Giulia Ginami and Karina Lopez and Radhouene Neji and Camila Munoz and Sebastien Roujol and Peter Mountney and Reza Razavi and Rene M Botnar and Claudia Prieto},
abstract={Atrial wall thickness quantification has the potential of providing important clinical information when planning electrophysiological interventions. Imprecise delivery of thermal energy during catheter ablation can prevent the success of the procedure. Furthermore, pre-interventional knowledge of subject-specific variations in the anatomy of the coronary sinus (CS) is crucial for adequate catheterization. Here, we propose a free-breathing 3D whole-heart phase-sensitive inversion recovery sequence suitable for non-contrast enhanced interventional planning, offering simultaneous visualization of the atrial walls and CS anatomy. The sequence is integrated in a framework with image-based navigation and non-rigid respiratory motion correction for 100\% scan efficiency and improved image sharpness.}
}
@inproceedings{ISMRM2018_4153,
annote={ISMRM2018_4153},
pages={4153},
file={ISMRM2018_4153.pdf:ISMRM2018_4153.pdf:PDF},
title={Active-tracked versus Passive-tracked {MRI}-guided Cervical-cancer Brachytherapy catheter placement in 11 patients: Improved accuracy and reduced procedure time},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4153.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jose De Arcos and Ehud J Schmidt and Wei Wang and Junichi Tokuda and Kamal Vij and Charles L Dumoulin and Ravi T Seethmaraju and Robert A Cormack and Akila N Viswanathan},
abstract={We performed MRI-guided placement of high dose rate (HDR) brachytherapy catheters in 11 cervical-cancer patients within a 3.0 T MRI scanner. We compared placing MR-tracked metallic stylets to passively-tracked conventional stylets. Comparisons were performed during three procedure stages: coarse stylet navigation to the approximate region of the tumor; fine-tuned navigation to the clinician’s desired (final) location; stylet pull-back (withdrawal) from the body, which provided catheter trajectories for Radiation Treatment Planning. Active-tracking’s main benefits; (I) catheters placed much closer to the clinician’s intended location, including via complex manipulations requiring complete withdrawal and repositioning, (II) placement durations similar to transrectal-ultrasound guided HDR procedures.}
}
@inproceedings{ISMRM2018_4154,
annote={ISMRM2018_4154},
pages={4154},
file={ISMRM2018_4154.pdf:ISMRM2018_4154.pdf:PDF},
title={Noninvasive assessment of great vessel stents using a susceptibility-based imaging method},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4154.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Caiyun Shi and Shi Su and Xin Liu and Dong Liang and Haifeng Wang and Jim Ji and Guoxi Xie},
abstract={Previous studies have demonstrated that a susceptibility-based positive contrast MR method exhibits excellent efficacy for visualizing MR compatible metal devices by taking advantage of their high magnetic susceptibility. However, the method was not evaluated in the assessment of stent restenosis. The purpose of this study is to assess whether the susceptibility-based positive method can be used to assess the stent restenosis, with the comparison of two typical MR positive contrast techniques, i.e., SUMO and GRASP. The experimental results showed that the susceptibility-based method not only provides better localization of the stent than SUMO and GRASP but also has capabiltiy to assess the stent restenosis.}
}
@inproceedings{ISMRM2018_4155,
annote={ISMRM2018_4155},
pages={4155},
file={ISMRM2018_4155.pdf:ISMRM2018_4155.pdf:PDF},
title={Percutaneous {MR}-guided Interventions Using an Optical Moiré Phase Tracking System},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4155.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Urte Kägebein and Frank Godenschweger and Frank Wacker and Oliver Speck and Bennet Hensen},
abstract={The development of an appropriate guidance support is essential to simplify and shorten MRI guided percutaneous interventions. We present a new tracking system and sequence enabling intuitive, interactive and precise instrument navigation with the aid of an optical Moiré Phase tracking system from the inside of the MRI scanner. The system was evaluated regarding targeting error and skin to target time by experienced interventional radiologist and novice users, revealing a precise (0.99mm±0.47mm), fast (155s±62s) and simple real-time needle guidance.}
}
@inproceedings{ISMRM2018_4156,
annote={ISMRM2018_4156},
pages={4156},
file={ISMRM2018_4156.pdf:ISMRM2018_4156.pdf:PDF},
title={Feasibility of {MRI} image based synthetic {CT} generation in radiotherapy using deep convolutional neural network},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4156.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yafen Li and Wen Li and Yaoqin Xie and Jun Xia},
abstract={Generating electronic density information for MRI images is crucial for MRI-based dose calculation in a MRI-only workflow of radiotherapy. To address this problem, we proposed a deep convolutional neural network plus with an auto-context model to predict synthetic CT from MRI images of routine-sequence. The highly accuracy of generated synthetic CT results shows that the proposed method is effective and robust.}
}
@inproceedings{ISMRM2018_4157,
annote={ISMRM2018_4157},
pages={4157},
file={ISMRM2018_4157.pdf:ISMRM2018_4157.pdf:PDF},
title={Transcatheter intra-arterial perfusion ({TRIP})-{MRI} for the evaluation of immediate Irreversible Electroporation effects in the {VX}2 rabbit liver tumor model.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4157.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Matteo Figini and Kang Zhou and Liang Pan and Junjie Shangguan and Chong Sun and Bin Wang and Na Shang and Quanhong Ma and Daniele Procissi and Andrew Christian Larson and Zhuoli Zhang},
abstract={Six rabbits with liver tumors underwent anatomical and perfusion MRI immediately after irreversible electroporation (IRE) treatment of the tumors, using a catheter inserted in the left hepatic artery to deliver the contrast agent (TRIP-MRI). All the treated regions showed low perfusion as measured by the Area under the tissue response Curve. In some cases, a rim or a few spots with higher AUC were present and were presumably associated with the penumbra of reversible electroporation that is known to be present in IRE-treated tissues. TRIP-MRI could be a valuable non-invasive tool to assess IRE effect and to immediately plan retreatment.}
}
@inproceedings{ISMRM2018_4158,
annote={ISMRM2018_4158},
pages={4158},
file={ISMRM2018_4158.pdf:ISMRM2018_4158.pdf:PDF},
title={Using 2D image slices for obtaining the guidewire coupling modes of a {PT}x transmit array},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4158.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Felipe Godinez and Arian Beqiri and Jose N Teixeira and Joseph V Hajnal and Shaihan Malik},
abstract={A multislice method for measuring relative coupling between elements of a parallel transmit (PTx) array and conductive structures such as guidewires at multiple internal locations. Fast 2D image slices are used to measure the relative coupling along the guidewire inside a large phantom. This is useful during conditions where the coupling modes can only be measured from within the object volume and where current sensors cannot be placed. Such conditions exist in large phantoms and can exist in humans.}
}
@inproceedings{ISMRM2018_4159,
annote={ISMRM2018_4159},
pages={4159},
file={ISMRM2018_4159.pdf:ISMRM2018_4159.pdf:PDF},
title={Intraarterial chemotherapy of glioblastoma following osmotic blood-brain barrier opening under real-time {MRI} guidance},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4159.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Chengyan Chu and Monica Pearl and Yanrong Chen and Anna Jablonska and Xiaolei Song and Miroslaw Janowski and Piotr Walczak},
abstract={Blood-brain barrier (BBB) prevents effective chemotherapy of brain tumors. Intra-arterial (IA) injection of hyperosmotic mannitol has been attempted for many years to permeabilize the BBB, however due to high variability, this procedure never became a routine clinical practice. We have previously shown that real-time MRI may circumvent that obstacle in large animal model. However, for drug screening purposes the mouse model if preferred. Here, we have shown that real-time, interventional MRI is also instrumental to precisely open BBB in rodents and more importantly combining it with subsequent delivery of chemotherapeutic drug melphalan provides therapeutic benefit warranting consideration of clinical application.}
}
@inproceedings{ISMRM2018_4160,
annote={ISMRM2018_4160},
pages={4160},
file={ISMRM2018_4160.pdf:ISMRM2018_4160.pdf:PDF},
title={Comparison of {MR}-guided joint injection with a fluoroscopic approach for pediatric {MR} arthrography},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4160.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Sphoorti Shellikeri and Anne Marie Cahill and Victor Ho-Fung and Randolph Setser and Michael Acord and Seth Vatsky and Fernando Escobar and Abhay Srinivasan},
abstract={Magnetic resonance imaging (MRI) provides excellent soft-tissue contrast and multiplanar capability in joint imaging, but often requires direct joint injection of gadolinium to provide adequate depiction of cartilage and ligaments. MRI-guided joint interventions are not commonly performed as routine practice. In MR arthrography, the contrast injections are usually performed under fluoroscopy and is followed by a diagnostic MRI to evaluate the abnormalities in the rotator cuffs. This work describes our experience with combined interventional and diagnostic MR shoulder arthrography and evaluates the efficacy of MR-guided injection, comparing technical success, diagnostic quality and procedure times to fluoroscopic-guided arthrography.}
}
@inproceedings{ISMRM2018_4161,
annote={ISMRM2018_4161},
pages={4161},
file={ISMRM2018_4161.pdf:ISMRM2018_4161.pdf:PDF},
title={Application of {SSFSE} T1-weighted imaging for {MRI}-guided bone biopsy},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4161.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Elena Kaye and Daniel V Litwiller and Maggie Fung and Stephen Solomon and Majid Maybody},
abstract={MRI guided biopsy plays an important role in the diagnosis of bone lesions. Although T1w FSE offers exceptional signal-to-noise ratio and resolution, its acquisition time is relatively long. In this study, we evaluate a single-shot FSE with centric partial Fourier encoding, variable refocusing flip angle and an inversion recovery preparation pulse (vrfSSFSE-IR) for MRI-guided bone biopsy application with the goal to reduce the overall procedure time.}
}
@inproceedings{ISMRM2018_4162,
annote={ISMRM2018_4162},
pages={4162},
file={ISMRM2018_4162.pdf:ISMRM2018_4162.pdf:PDF},
title={Real-Time Golden Angle Radial i{SSFP}: Impact of the Gradient Spoiler Direction on Motion and Flow Effects},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4162.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Samantha Mikaiel and Thomas Martin and Xiaodong Zhong and Kyunghyun Sung and Holden H Wu},
abstract={Real-time visualization is crucial to the success of MRI-guided minimally invasive cancer interventions. We have developed golden-angle (GA) ordered radial integrated-SSFP (iSSFP), which can suppress banding artifacts associated with bSSFP while maintaining similar contrast. However, the addition of the gradient spoiler in iSSFP removes the flow and motion compensation along the axis of the gradient. In this work, we analyze pelvic and abdominal iSSFP scans acquired in the axial, sagittal and coronal planes to investigate the effects of having the gradient along different directions with respect to motion/flow. GA radial iSSFP can potentially improve tissue contrast for real-time MRI-guided interventions, after careful consideration for the imaging plane, gradient spoiler direction and motion/flow direction.}
}
@inproceedings{ISMRM2018_4163,
annote={ISMRM2018_4163},
pages={4163},
file={ISMRM2018_4163.pdf:ISMRM2018_4163.pdf:PDF},
title={Accuracy and Time Efficiency of Real-Time {MRI}-Guided Remote-Controlled Targeted Needle Placement During Motion Using Hydrostatic Actuators},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4163.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Samantha Mikaiel and James Simonelli and Xinzhou Li and Yu-Hsiu Lee and Yong Seok Lee and Kyunghyun Sung and David Lu and Tsu-Chin Tsao and Holden H Wu},
abstract={In this work, we investigate the accuracy and time efficiency for real-time MRI-guided targeted needle placement using a rolling-diaphragm hydrostatic actuator system during motion. We show that the actuator-assisted approach was able to guide the needle to targets with greater accuracy and in less time than the conventional step-and-shoot strategy for both static and dynamic conditions using a programmable motion phantom. The new actuator system can potentially enable physicians to remotely perform real-time MRI-guided interventions during motion.}
}
@inproceedings{ISMRM2018_4164,
annote={ISMRM2018_4164},
pages={4164},
file={ISMRM2018_4164.pdf:ISMRM2018_4164.pdf:PDF},
title={Non-contrast {MRA} Guidance in Pediatric Endovascular Interventions},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4164.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Lingyun Chen and Onno Wink and Amber Pokorney and Ryan Robison and Robyn Augustyn and Marrit Thorkelson and Richard Towbin},
abstract={The goal of this research project is to investigate the feasibility of using non-contrast 3D MRA imaging in the planning and guidance of catheter-based pediatric vascular disease treatment. It may result in a reduction in patient radiation exposure, contrast (Gadolinium and Iodine) usage and procedure time as compared to traditional 2D fluoroscopy guidance.}
}
@inproceedings{ISMRM2018_4165,
annote={ISMRM2018_4165},
pages={4165},
file={ISMRM2018_4165.pdf:ISMRM2018_4165.pdf:PDF},
title={A Phantom for Evaluation of Motion Quantification Methods in {MR}-Guided Radiotherapy},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4165.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Lukas Leiner and Gernot Echner and Matthias Borutta and Reiner Umathum and Arthur W. Magill and Steffen Seeber and Sebastian Flassbeck and Florian Friedrich and Anna Fischer and Nicolas G. R. Behl and Mark E. Ladd and Florian Maier},
abstract={MR-guided radiotherapy enables real-time tracking of targets during therapy application, with the aim of improving targeting accuracy and, hence, treatment efficiency. To evaluate MR-based motion quantification techniques, a phantom that can generate reproducible, known motion is an extremely valuable tool. A modular motion phantom was designed and implemented that provides precise and reproducible linear motion, including accurate position information. The phantom was found to be MR-compatible. An initial evaluation of real-time bSSFP imaging was performed. The developed device can be used as research tool for MR-guided therapy and as a clinical quality assessment tool to improve treatment of patients.}
}
@inproceedings{ISMRM2018_4166,
annote={ISMRM2018_4166},
pages={4166},
file={ISMRM2018_4166.pdf:ISMRM2018_4166.pdf:PDF},
title={Imaging latencies for Cartesian and Golden Angle 2D {MRI} in real-time {MR}-guided radiotherapy},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4166.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Pim T.S. Borman and Rob H.N. Tijssen and Clemens Bos and Chrit T.W. Moonen and Bas W. Raaymakers and Markus Glitzner},
abstract={For tumor tracking it is vital to minimize the latency between the moment of anatomic change and its appearance on the MR image. Apart from the temporal footprint of the acquisition, the readout trajectory itself influences the latency. We explore how the latency is minimized by shifting the collection of the center of k-space to the end of the acquisition. For Cartesian sequences this is achieved by changing the profile order, whereas in golden angle acquisitions a smaller window or k-t filter is able to achieve this.}
}
@inproceedings{ISMRM2018_4167,
annote={ISMRM2018_4167},
pages={4167},
file={ISMRM2018_4167.pdf:ISMRM2018_4167.pdf:PDF},
title={A Three-dimensional Template Matching Technique in Target Tracking Technique of {MR}g{HIFU} for liver},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4167.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Tomiki Morita and Etsuko Kumamoto and Daisuke Kokuryo and Kagayaki Kuroda},
abstract={MRgHIFU treatment for liver requires a tracking technique to “lock on” to the focal spot at the target tissue region during respiratory-induced motion. We proposed three-dimensional focus tracking technique using template matching method. In this method, by creating a deformity / mutation model reconstructed from multi-slice volume data and extracting multiple blood vessel branch points, the focal spot can be estimated from the relative positional relationship. In this study, we optimized template size of template matching for extracting branching points in preoperative. Experimental results demonstrated to improve accuracy of blood vessel extraction.}
}
@inproceedings{ISMRM2018_4168,
annote={ISMRM2018_4168},
pages={4168},
file={ISMRM2018_4168.pdf:ISMRM2018_4168.pdf:PDF},
title={Robust quantitative diffusion weighted {MR} on an {MR}-Linac system},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4168.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Tim Schakel and Rob H.N. Tijssen and Hans M. Hoogduin and Marielle E.P. Philippens},
abstract={Quantitative diffusion weighted imaging is demonstrated on a clinical MR-Linac system. ADC values were measured using a standardized diffusion phantom using two different diffusion sequences, single shot EPI and single shot TSE: SPLICE. In general, accurate and repeatable ADC measurements could be acquired using both sequences. EPI showed more susceptibility and eddy current related image distortions, whereas SPLICE was geometrically more robust. Large deviations in ADC start to occur when moving further away from the isocenter, suggesting the need for gradient non-linearity correction of ADC values.}
}
@inproceedings{ISMRM2018_4169,
annote={ISMRM2018_4169},
pages={4169},
file={ISMRM2018_4169.pdf:ISMRM2018_4169.pdf:PDF},
title={Real-time {SNR} enhancement in surgical region for intraoperative {MRI} combining a stationary and a small freely-moving {RF} coils},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4169.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jun-Hee Kim and Won-Joon Do and Jong-Woo Lim and Sang-Chul Lee and Sung-Hong Park},
abstract={This study introduces a new technique to enhance SNR in a surgical region for real-time intraoperative MRI that combines a static big and an endoscopic small RF coils. Segmented imaging using the static RF coil and fast imaging using the small RF coil were performed simultaneously with a reduced FOV. The images from the static and freely-moving RF coils were updated in multiple shots and in every shot, respectively. This technique not only reduces computing time, but also improves SNR in surgical region without intensity variation, which would be beneficial in intraoperative MRI.}
}
@inproceedings{ISMRM2018_4170,
annote={ISMRM2018_4170},
pages={4170},
file={ISMRM2018_4170.pdf:ISMRM2018_4170.pdf:PDF},
title={3D specific absorption rate estimation from focused ultrasound sonications using the Green’s function heat kernel},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4170.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Nick Freeman and Henrik Odéen and Dennis L Parker},
abstract={In-vivo determination of tissue thermal and acoustic properties, such as the specific absorption rate (SAR) for focus ultrasound, are important for accurate thermal modeling in treatment planning, monitoring and control using, e.g., Pennes bioheat transfer equation. In this work we derive and present a numerical method using the Green’s function and MR thermometry data as input to estimate SAR non-invasively. The method is as accurate but substantially faster (on the order of seconds, compared to minutes) compared to two other SAR determination methods. Simulation and phantom experiments in a tissue mimicking gel phantom are performed.}
}
@inproceedings{ISMRM2018_4171,
annote={ISMRM2018_4171},
pages={4171},
file={ISMRM2018_4171.pdf:ISMRM2018_4171.pdf:PDF},
title={Assessment of Immediate Response to Irreversible Electroporation for Targeted Ablation of Liver Tissues Using Dynamic Contrast Enhancement in a Rabbit Model},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4171.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Junjie Shangguan and Matteo Figini and Chong Sun and Liang Pan and Bin Wang and Quanhong Ma and Kang Zhou and Na Shang and Zhuoli Zhang},
abstract={Irreversible electroporation (IRE) may be visualized by MRI immediately post-procedure to monitor and assess tissue response peri-operatively. Dynamic contrast-enhanced MRI (DCE-MRI) allows measurement of tissue perfusion. We will demonstrate that DCE-MRI allows early visualization of IRE ablated tissue margins for prediction of the ablated region and quantification of tissue response. 6 rabbits underwent IRE ablation of the liver and pre-IRE and post-IRE DCE-MRI. A decrease in post-IRE apparent diffusion coefficients in the ablated region compared with baseline indicates tissue damage. Post-IRE AUC is decreased compared with baseline, suggesting decreased but still present blood perfusion in the ablated region post-IRE.}
}
@inproceedings{ISMRM2018_4172,
annote={ISMRM2018_4172},
pages={4172},
file={ISMRM2018_4172.pdf:ISMRM2018_4172.pdf:PDF},
title={Dedicated 3-Channel Surface Coil for Interventional Magnetic Resonance Imaging at 3T - First Evaluation},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4172.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Lena Sonnow and Wesley D Gilson and Arne Hengerer and Clifford R Weiss and Himanshu Bhat and Frank Wacker and Jan Fritz},
abstract={We developed a dedicated interventional MRI coil with 3 receiver channels and a wide central aperture for interventional access, which we benchmarked against a 4-channel system surface coil. We assessed signal-to-noise-ratios (SNR), geometry (g)-factors and instrument artifact size in a phantom and 100 subjects. The interventional MRI prototype coil produced similar SNR values and g-factors than the 4-channel system coil. There was no significant difference in artifacts, which were suitable for accurate and safe procedures. The central aperture of the interventional MRI prototype coil improved access and the coil performed error-free during a large variety of interventional MRI procedures.}
}
@inproceedings{ISMRM2018_4173,
annote={ISMRM2018_4173},
pages={4173},
file={ISMRM2018_4173.pdf:ISMRM2018_4173.pdf:PDF},
title={Validation study of high framerate source localization for {MR}-guided {HDR} brachytherapy},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4173.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ellis Beld and Marinus A. Moerland and Max A. Viergever and Jan J.W. Lagendijk and Peter R. Seevinck},
abstract={For the development of MR-guided high-dose-rate (HDR) brachytherapy, the accuracy and precision of an MR-based HDR source localization method were investigated in a phantom study, by a comparison with CT. MR images were acquired for various angulations of the source with respect to B
0 and a 3D CT scan was acquired. The MR source positions were compared to the CT source position. The results demonstrated a high, subvoxel accuracy (0.4-0.6 mm) and a high precision (≤0.1 mm) at high temporal resolutions (0.15-1.2 s per slice). This proved that our proposed MR-based source localization method is valuable for MR-guided HDR brachytherapy.}
}
@inproceedings{ISMRM2018_4174,
annote={ISMRM2018_4174},
pages={4174},
file={ISMRM2018_4174.pdf:ISMRM2018_4174.pdf:PDF},
title={Platform for investigating spatial and intensity parameters for phase-sensitive {MRI} focal localization with steerable single element focused ultrasound transducers through skull},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4174.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Spencer Brinker and Frank Preiswerk and Nathan McDannold},
abstract={A platform is designed and constructed for investigating Focused Ultrasound (FUS) spatial and intensity focal parameters during phase-sensitive MRI focal localization. Recently, there has been a large interest to use single element transducers to deliver therapy to the brain. Spatial accuracy and intensity safety limits need further investigation. The platform developed in this project uses 3D Slicer software to incorporate MRI and neuronavigation camera coordinates for guiding an automated 3D hydrophone mapping system. A 272 kHz single element FUS transducer, ex vivo skull and gel phantom are used to demonstrate components of the integrated MRI and navigation based hydrophone mapping system.
}
}
@inproceedings{ISMRM2018_4175,
annote={ISMRM2018_4175},
pages={4175},
file={ISMRM2018_4175.pdf:ISMRM2018_4175.pdf:PDF},
title={Simulation of Peripheral Nerve Stimulation Thresholds of {MRI} Gradient Coils},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4175.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Mathias Davids and Bastien Guérin and Valerie Klein and Lothar R Schad and Lawrence L Wald},
abstract={Peripheral Nerve Stimulation (PNS) has become the major limitation in many fast MRI sequences for state-of-the-art gradient systems. We recently presented the first (to our knowledge) full peripheral nerve model for assessing magnetostimulation thresholds and validated it for solenoid coils. Our model consists of a comprehensive body model for EM simulations, a detailed atlas of human nerve fibers and a numerical model describing nerve responses to induced electrical fields. Here, we extend our approach to realistic MRI gradient coils in simulations of male and female body models. The average threshold closely matches experimentally obtained group PNS threshold curves.}
}
@inproceedings{ISMRM2018_4176,
annote={ISMRM2018_4176},
pages={4176},
file={ISMRM2018_4176.pdf:ISMRM2018_4176.pdf:PDF},
title={Automatic Generation of Topologically Correct, High Quality, Finite-Element Tetrahedral Body Models from Voxel and Surface Data},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4176.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Mathias Davids and Bastien Guérin and Lawrence L Wald and Lothar R Schad},
abstract={Assessment of MR safety, e.g., Specific Absorption Rate (SAR) and Peripheral Nerve Stimulation (PNS), relies on the accurate estimation of electromagnetic fields in complex human body models. Finite Element Methods (FEM) can use tetrahedral meshes that can model curved geometries much more accurately than voxel-based meshes. The creation of high-quality surface body models (needed to generate tetrahedral meshes), however, is complex due to the requirements for the surface models (water-tightness, correct topology, no intersections, etc.). We developed an automatic pipeline that, starting with arbitrary surface and voxel data, generates high quality, watertight, topologically correct surface models to be practically useful in FEM simulations.}
}
@inproceedings{ISMRM2018_4177,
annote={ISMRM2018_4177},
pages={4177},
file={ISMRM2018_4177.pdf:ISMRM2018_4177.pdf:PDF},
title={Optimization of the order and spacing of the sequences in an {MRI} examination to minimize the thermal dose},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4177.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Giuseppe Carluccio and Christopher Michael Collins},
abstract={Thermal dose is a parameter to evaluate the potential to damage tissues by exposure to high temperatures. In case of SAR-induced heating, we show that the maximum thermal dose can be reduced by changing the order of the sequences and delays between sequences without increasing the total exam duration. Using numerical simulations, we have optimized the order of the sequences of a comprehensive spine exam and the optimized sequence has a maximum thermal dose equal to 0.80 cumulative equivalent minutes at 43 °C (CEM43), while the original exam had a maximum thermal dose equal to 1.72 CEM43.}
}
@inproceedings{ISMRM2018_4178,
annote={ISMRM2018_4178},
pages={4178},
file={ISMRM2018_4178.pdf:ISMRM2018_4178.pdf:PDF},
title={Impact of Constant {BMI} and Variable Lean-Body-Mass on B1+ and {SAR}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4178.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Matthew Tarasek and Yihe Hua and Desmond Yeo and Thomas Foo},
abstract={Magnetic resonance imaging (MRI) uses radiofrequency energy which is absorbed by the patient. This energy is expressed in terms of specific absorption rate (SAR). Here we analyze the EM and thermal effects of increased lean-body-mass proportions with constant body-mass-index (BMI). We use a combination of techniques to achieve morphed expansion of lean-body-mass (LBM muscle) of non-head skeletal muscle tissue in a computational anatomical human body model. Results indicate that LBM may be a worthwhile anatomical descriptor to consider for impact on thermal risk assessment.}
}
@inproceedings{ISMRM2018_4179,
annote={ISMRM2018_4179},
pages={4179},
file={ISMRM2018_4179.pdf:ISMRM2018_4179.pdf:PDF},
title={Effects of Respiration on B1+ and {SAR} in Whole-Body Imaging at 7 Tesla},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4179.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Emma Doran and Stephen Bawden and Paul Glover and Susan Francis and Richard Bowtell and Penny A. Gowland},
abstract={The work aimed to quantify the effect of the phase of respiration on calculated local SAR and B
1+ excitation fields using electromagnetic simulations using XFDTD software and to verify these results by comparing with B
1+ maps acquired in vivo. The results show that the variation in local SAR was greater for the anterior elements due to the movement of the chest between inhale and exhale breath holds. The change in B
1+ in the abdominal organs and in regions of interest under each transmit element was not significant.}
}
@inproceedings{ISMRM2018_4180,
annote={ISMRM2018_4180},
pages={4180},
file={ISMRM2018_4180.pdf:ISMRM2018_4180.pdf:PDF},
title={Investigating the Relationship between {CEM}43 and Brain Tissue Damage with {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4180.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yigitcan Eryaman and Lynn Utecht and Dee M Koski and Gregor Adriany and Noam Harel and Kamil Ugurbil and J. Thomas Vaughan},
abstract={An experimental paradigm that can be used to investigate the relationship between CEM43 metric and tissue damage is presented.}
}
@inproceedings{ISMRM2018_4181,
annote={ISMRM2018_4181},
pages={4181},
file={ISMRM2018_4181.pdf:ISMRM2018_4181.pdf:PDF},
title={Simple transmission antenna resonance Q value measurement method using {RF} power monitors},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4181.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Hideta Habara and Yoshiaki Sato and Masaharu Ono and Kenta Sakuragi and Masahiro Takizawa and Kosuke Ito},
abstract={In MRI system it is important that whole body SAR is controlled accurately to obtain good scanning images and to keep patients' safety. A simple transmission antenna resonance Q value measurement system has been developed using conventional RF power monitors. The system has been validated comparing with the network analyzer measurements. Based on this validation, whole-body SAR management system was integrated. Using the integrated system, accurate whole-body SAR management has been made possible.}
}
@inproceedings{ISMRM2018_4182,
annote={ISMRM2018_4182},
pages={4182},
file={ISMRM2018_4182.pdf:ISMRM2018_4182.pdf:PDF},
title={Reducing {PNS} with Minimal Performance Penalties via Simple Pulse Sequence Modifications on a Compact 3T Scanner},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4182.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Myung-Ho In and Yunhong Shu and Joshua D Trzasko and Shengzhen Tao and Erin M Gray and John Huston and Matt A Bernstein},
abstract={More than 170 volunteers (patient subjects and normal controls) have been scanned since April 2016 following installation of a compact 3T MRI system with high-performance gradients (gradient strength=80mT/m, slew-rate=700T/m/s) at our institution. Despite peripheral nerve stimulation (PNS) related concerns associated with the high-performance gradients, no or minimal PNS sensation has been reported, with the exception of three normal control subjects. To mitigate the effect of PNS in these and other especially sensitive subjects, a simple pulse sequence modification was developed. Two of the subjects who reported PNS from their initial exam were available to be re-imaged with the modified pulse sequence and subsequently reported no PNS.}
}
@inproceedings{ISMRM2018_4183,
annote={ISMRM2018_4183},
pages={4183},
file={ISMRM2018_4183.pdf:ISMRM2018_4183.pdf:PDF},
title={The impact of pad thickness on {RF} burn prevention: is a 1mm pad sufficient?},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4183.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Michael Steckner and Xin Chen},
abstract={RF burns are typically categorized according to appearance and suspected mechanism. Skin/skin contact burns are postulated to be caused by significant current flows through a restricted contact area. While not definitively proven, patients are instructed to not clasp hands and pads should be routinely used to minimize skin/skin contact. The effectiveness of a thin pad is investigated with EM modeling. A reported calf burn (peak 10g SAR:whole body SAR ratio ~86) may be avoidable with a 1 mm air gap (SAR hotspot ratio ~2). Understanding that thin pads are sufficient may permit greater flexibility in possible pad solutions.}
}
@inproceedings{ISMRM2018_4184,
annote={ISMRM2018_4184},
pages={4184},
file={ISMRM2018_4184.pdf:ISMRM2018_4184.pdf:PDF},
title={Variation in {RF} shimming {SAR} with patient position for 3 T breast imaging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4184.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Mariya Lazebnik},
abstract={This work investigates the variation in peak spatial SAR for RF shimming for different patient positions in the MR scanner for breast imaging. SAR simulations were performed on the Ella human body model in a 3 T 70 cm-diameter RF birdcage coil. Whole body SAR, peak spatial SAR and SAR ratio (= peak SAR / whole body SAR) were computed for different patient elevations above the table (i.e., the patient lying on top of a breast coil). Patient position has important implications for setting safe RF shimming ranges due to the variations in peak spatial SAR in different patient positions.}
}
@inproceedings{ISMRM2018_4185,
annote={ISMRM2018_4185},
pages={4185},
file={ISMRM2018_4185.pdf:ISMRM2018_4185.pdf:PDF},
title={Comparison of electromagnetic and thermal simulations with measurements of different orthopedic implants system at 1.5T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4185.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Keran Wang and Zainul Ihsan and Joerg Seehafer and Thomas Doering and Wolfgang Goertz and Gregor Schaefers},
abstract={With aid of the numerical simulations the test of a typical commercial orthopedic implant system composed of huge amount of multi-component implants varying in dimensions or materials is doable in realistic time and cost regarding the radio frequency induced heating. Electromagnetic and thermal simulations are applied to confirm the worst case configuration, locate the hotpot and interpret the temperature rise which is compared with the experiment test. To catch the worst case scenario the placement of the test object should be considered in relation to the local electrical field and the setup of simulation should approach the experimental condition.}
}
@inproceedings{ISMRM2018_4186,
annote={ISMRM2018_4186},
pages={4186},
file={ISMRM2018_4186.pdf:ISMRM2018_4186.pdf:PDF},
title={B1+ and Temperature Analysis in Two {UHF} {RF} Coils},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4186.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Sossena Wood and Tales Santini and Nadim Farhat and Tiago Martins and Narayanan Krishnamurthy and Tamer S Ibrahim},
abstract={Our work makes a comparison of the RF performance of a TEM resonator and a TTT coil on a 2-compartment agar phantom. While the results show lower B1+/RF power efficiency for the TTT coil when compared to the TEM coil, the temperature rise in the TEM coil is higher (resulting in lower B1+/SAR efficiency) for a fixed average B1+ intensity across the volume of the coil load.}
}
@inproceedings{ISMRM2018_4187,
annote={ISMRM2018_4187},
pages={4187},
file={ISMRM2018_4187.pdf:ISMRM2018_4187.pdf:PDF},
title={Reduced {SAR} excitation with linear phase coils},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4187.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Glen Morrell and Rock Hadley},
abstract={A novel method for SAR reduction for slice- or slab-selective excitation is proposed which uses an array of two linear phase RF coils and two channel transmission to reduce SAR with no change in pulse length, bandwidth, or slice profile compared to conventional excitation. FDTD simulation results show a reduction of SAR by a factor of two.}
}
@inproceedings{ISMRM2018_4188,
annote={ISMRM2018_4188},
pages={4188},
file={ISMRM2018_4188.pdf:ISMRM2018_4188.pdf:PDF},
title={Assessment of high dielectric material in different sizes for fetal {MRI} at 3T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4188.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Chao Luo and Nan Li and Guoxi Xie and Xiaoliang Zhang and Xin Liu and Ye Li},
abstract={In this paper, we investigate the effect of the size and thickness of high permittivity dielectric pads to the imaging performance in fetal imaging at 3T through numerical modeling and simulations. The results of this study can be used as a guide in selection of appropriate size and thickness of dielectric pads in fetal magnetic resonance imaging for gaining the highest imaging performance.}
}
@inproceedings{ISMRM2018_4189,
annote={ISMRM2018_4189},
pages={4189},
file={ISMRM2018_4189.pdf:ISMRM2018_4189.pdf:PDF},
title={Evaluation of Macrocyclic Gadolinium-Based Contrast Agent Retention in a Longitudinal Multiple Sclerosis Study},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4189.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Gabriel Kocevar and Salem Hannoun and Claudio Stamile and François Cotton and Françoise Durand-Dubief and Dominique Sappey-Marinier},
abstract={Gadolinium-based contrast agents (GBCA) are commonly used to identify blood-brain-barrier disruption. Recent studies reported gadolinium deposition in deep gray matter (GM) structures, following serial injections of linear complexes of GBCA. While it is recognized that linear complexes of GBCA may lead to gadolinium retention in brain, macrocyclic GBCA should also be evaluated. In this study, we investigated the effect of serial macrocyclic GBCA injections in 92 Multiple Sclerosis patients followed during seven years. Our results did not show any significant signal intensity changes in deep GM structures and particularly in the dentate nuclei and the globus pallidus.}
}
@inproceedings{ISMRM2018_4190,
annote={ISMRM2018_4190},
pages={4190},
file={ISMRM2018_4190.pdf:ISMRM2018_4190.pdf:PDF},
title={Deep Learning Enables 90\% Reduction in Gadolinium Dosage for Contrast Enhanced {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4190.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Enhao Gong and John Pauly and Max Wintermark and Greg Zaharchuk},
abstract={There are increasing concerns over gadolinium-based-contrast-agents-administration(GBCA). A deep-learning (DL) method was developed to reduce the gadolinium dose in Contrast-Enhanced-MRI (CE-MRI). The proposed method includes an acquisition step(pre-contrast, 10\% low-dose and full-dose CE-MRI with T1-weighted-IR-FSPGR), a pre-processing step and a deep learning model trained to predict full-dose CE-MRI from pre-contrast and low-dose images. Evaluated on a clinical neuro CE-MRI dataset (10 patients for training and another 20 patients for evaluation), both quantitative metrics and radiologists’ ratings showed the proposed method achieved improved synthesis, with better motion-artifact-suppression and NO significant differences in contrast-enhancement quality, compared with ground-truth full-dose CE-MRI. Thus, using the proposed Deep Learning method, GBCA can be reduced, by at-least-10-fold, while preserving image quality and diagnostic information.}
}
@inproceedings{ISMRM2018_4191,
annote={ISMRM2018_4191},
pages={4191},
file={ISMRM2018_4191.pdf:ISMRM2018_4191.pdf:PDF},
title={New occurrences of macroscopic myocardial fibrosis in thalassemia at long term by multiple follow-up},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4191.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Antonella Meloni and Vincenzo Positano and Laura Pistoia and Pietro Giuliano and Stefania Renne and Riccardo Righi and Priscilla Fina and Petra Keilberg and Crocetta Argento and Cristina Paci and Antonella Massa and Alessia Pepe},
abstract={We investigated the evolution of myocardial fibrosis in terms of new occurrences over a period of 6 years in thalassemia patients who underwent to multiple LGE CMR scans and we detected an high number of new occurrences of myocardial fibrosis. Our data suggest the importance of repeating the LGE CMR over time using 'low risk' macrocyclic agents.}
}
@inproceedings{ISMRM2018_4192,
annote={ISMRM2018_4192},
pages={4192},
file={ISMRM2018_4192.pdf:ISMRM2018_4192.pdf:PDF},
title={Absence of T1 hyperintensity in the brain of high-risk iron loaded thalassemia patients after multiple administrations of high dose Gadobutrol},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4192.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Antonella Meloni and Domenico Montanaro and Vincenzo Positano and Daniele De Marchi and Mariachiara Resta and Petra Keilberg and Laura Pistoia and Anna Spasiano and Tommaso Casini and Caterina Cinzia De Bari and Sara De Cori and Alessia Pepe},
abstract={Our study describes the lack of increased signal intensity (SI) in T1-weighted MRI images after repeated administrations of Gadobutrol in a high-risk population (high dose/scan, iron overload that facilitates the transmetallation of gadolinium). A potential role of the chelation therapy cannot be excluded. Moreover, it is highlighted that SI ratios in the sampled areas differ between 1.5T and 3T.}
}
@inproceedings{ISMRM2018_4193,
annote={ISMRM2018_4193},
pages={4193},
file={ISMRM2018_4193.pdf:ISMRM2018_4193.pdf:PDF},
title={Safety for the Off-label Use of Ferumoxytol in Magnetic Resonance Imaging: Early Results from the FeraSafe Multi-Center Registry™},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4193.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Kim-Lien Nguyen and Rola Saouaf and Cynthia K. Rigsby and Lindsay M. Griffin and Mark L. Fogel and Kevin K. Whitehead and Mark L. Schiebler and David E. Newby and J. Paul Finn},
abstract={Ferumoxytol is approved in the United States (U.S.) for treatment of iron deficiency anemia in chronic kidney disease. However, its superparamagnetic properties can be leveraged for off-label use in MRI. In 2015, the U.S. Food and Drug Administration (FDA) issued a “black-box” warning regarding risk of rare but serious hypersensitivity reactions based on post-marketing surveillance therapeutic use data. Preliminary experience from the FeraSafe Multi-Center Registry
TM suggests a low incidence of adverse events with the off-label diagnostic use of ferumoxytol. To date, these preliminary results suggest that with appropriate clinical use and monitoring, there is an acceptable benefit /risk profile.}
}
@inproceedings{ISMRM2018_4194,
annote={ISMRM2018_4194},
pages={4194},
file={ISMRM2018_4194.pdf:ISMRM2018_4194.pdf:PDF},
title={Mapping Gadolinium Entry and Clearance from the Brain using Dynamic {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4194.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Payam Nahavandi and Ian F Harrison and May Z Thin and John J Connell and Ozama Ismail and Yolanda Ohene and Jack A Wells and Mark F Lythgoe},
abstract={Recently, evidence for gadolinium retention in the brain was provided, raising concerns regarding the safety of these agents. This accumulation raised important questions, most crucially, by which pathway does gadolinium enter the brain. We provide insight into this by dynamic monitoring of the infiltration and clearance of gadolinium into the brain parenchyma following an IV injection. Following gadolinium injection, inflow of contrast into the cerebrospinal fluid spaces was prominent. 25mins post injection, contrast enhancement is detected in the periventricular regions and hypothalamus. This finding provides insight into the entry routes by which gadolinium infiltrates the brain following a systemic administration.}
}
@inproceedings{ISMRM2018_4195,
annote={ISMRM2018_4195},
pages={4195},
file={ISMRM2018_4195.pdf:ISMRM2018_4195.pdf:PDF},
title={Linear contrast agent-induced high signal intensity in the dentate nucleus and globus pallidus on unenhanced T1-weighted images in pediatric patients},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4195.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Shintaro Ichikawa and Utaroh Motosugi and Yoshie Omiya and Hiroshi Onishi},
abstract={Hyperintensity in the dentate nucleus (DN) and globus pallidus (GP) on unenhanced T1-weighted images (T1WI) was associated with previous administration of linear gadolinium-based contrast agent (GBCA) in pediatric patients. The DN-to-pons ratio increased as the number of linear GBCAs administrations increased. The GP-to-thalamus ratio of the “Linear GBCAs ≥ 5 administrations” group was significantly higher than that of the “No GBCAs administration” and the “Linear GBCAs 1–4 administrations” groups. The number of previous administrations of linear GBCAs was positively correlated with the DN-to-pons ratio and the GP-to-thalamus ratio.}
}
@inproceedings{ISMRM2018_4196,
annote={ISMRM2018_4196},
pages={4196},
file={ISMRM2018_4196.pdf:ISMRM2018_4196.pdf:PDF},
title={{STUDY} {OF} {SKIN} {ENHANCEMENT} {BY} {AGE} {IN} {WOMEN}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4196.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Akira Yamamoto and Tsutomu Okada and Yasutaka Fushimi and Tomohisa Okada and Kaori Togashi},
abstract={In women, the head skin signal enhancing effect tends to decrease with age.}
}
@inproceedings{ISMRM2018_4197,
annote={ISMRM2018_4197},
pages={4197},
file={ISMRM2018_4197.pdf:ISMRM2018_4197.pdf:PDF},
title={Dentate Nucleus Signal Intensity Decrease on T1-Weighted {MR} Images after Switching from Linear to Macrocyclic {GBCA}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4197.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ashkan Heshmatzadeh Behzadi and Yize Zhao and Zerwa Farooq and George Shih and Martin R. Prince},
abstract={Dentate Nucleus signal intensity ratios decreased with time after switching from linear (gadopentetate) to macrocyclic (gadobutrol) agent.}
}
@inproceedings{ISMRM2018_4198,
annote={ISMRM2018_4198},
pages={4198},
file={ISMRM2018_4198.pdf:ISMRM2018_4198.pdf:PDF},
title={Gd accumulation in tissues of healthy mice upon repeated administrations of Gd-based contrast agents},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4198.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Eliana Gianolio and Enza Di Gregorio and Giuseppe Ferrauto and Silvio Aime},
abstract={GBCAs are routinely used in many clinical MRI protocols, their high stability should ensure that the Gd-complexes are excreted intact without side effects. Recently, it was reported that tiny amounts of Gd3+ may be retained in the brain of patients. The aim of this study was to investigate, in an animal model, the in vivo fate of Gadoteridol and Gadodiamide extending the investigation of Gd retention to other body tissues besides brain. Several administration protocols differing for i) the number of total doses, ii) the frequency of the administrations and iii) the sacrifice time after the last administration, were compared.
}
}
@inproceedings{ISMRM2018_4199,
annote={ISMRM2018_4199},
pages={4199},
file={ISMRM2018_4199.pdf:ISMRM2018_4199.pdf:PDF},
title={Variability of B1+ and B0 fields in the human brain at 7T.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4199.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={William T Clarke and Olivier Mougin and Ian D Driver and Catarina Rua and Susan Francis and Richard Bowtell and Richard Wise and Adrian Carpenter and Keith Muir and Stuart Clare},
abstract={B
1+ and B
0 whole brain field-maps were collected from three human subjects, on four different 7 tesla scanners. Three different scanner systems from two different vendors were used; all acquisitions used the same RF coil. The data was used to assess the inter-subject and inter-scanner variability and to calculate typical field values over a range of different brain regions. Systematic difference in B
1+ calibration and B
0 shimming between scanners were found, necessitating user validated B
1+ calibration and B
0 shimming for quantitative multi-site studies.}
}
@inproceedings{ISMRM2018_4200,
annote={ISMRM2018_4200},
pages={4200},
file={ISMRM2018_4200.pdf:ISMRM2018_4200.pdf:PDF},
title={Comparison of {ASL} quantification results across 3T scanners with different hardware/software – insight for multisite {ASL} studies},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4200.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yu Fen Chen and James Patrick Higgins and Todd B Parrish},
abstract={Combination of data across different scanner platforms is a major concern for multisite studies. The quantitative nature of arterial spin labeling (ASL) is thought to be free from such concerns, but our results on data collected on the same scanner before and after hardware upgrade demonstrate that ASL is also subject to this confound. Normalization to a reference region greatly reduces variation even for non-quantitative data and is a recommended approach for removing scanner-related variations.}
}
@inproceedings{ISMRM2018_4201,
annote={ISMRM2018_4201},
pages={4201},
file={ISMRM2018_4201.pdf:ISMRM2018_4201.pdf:PDF},
title={Initial Investigation of Multi-Probe Magnetic Field Monitoring on a Whole-Body Human System Operating at 10.5 Tesla: Application to Spin Echo Diffusion Weighted {EPI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4201.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ruoyun E Ma and Edwards Auerbach and Kamil Ugurbil and Pierre-François Van de Moortele},
abstract={DW-EPI is subjected to image distortion induced by eddy currents. Magnetic field camera has been shown to provide corrected reconstruction based on accurate measurement of actual k-space trajectories. In this study, initial effort was made to implement this approach in the context of a whole body human system operating at 10.5T where susceptibility challenges are greater. After characterization of the probe behavior and careful design of the probe signal acquisition scheme, field evolution during the EPI readout was mapped. Image reconstruction corrected with the measured encoding information demonstrated a significant reduction of image distortion in DW-EPI.}
}
@inproceedings{ISMRM2018_4202,
annote={ISMRM2018_4202},
pages={4202},
file={ISMRM2018_4202.pdf:ISMRM2018_4202.pdf:PDF},
title={Motion Encoding Gradient Nonlinearity Correction for Magnetic Resonance Elastography},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4202.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Joshua D. Trzasko and Arvin Arani and Philip A. Araoz and Matt A. Bernstein and Richard L. Ehman and John Huston III and Yunhong Shu and Ek Tsoon Tan},
abstract={Due to engineering limitations, the spatial encoding gradient fields produced by an MRI scanner are never perfectly linear. Gradient non-ideality is typically associated with image geometric distortion, but it also imparts spatially varying bias in the signal generated during gradient-based motion encoding. In this work, we theoretically investigate how motion encoding gradient nonlinearity affects MR elastography and develop a corrective strategy applicable to any MRE protocol.}
}
@inproceedings{ISMRM2018_4203,
annote={ISMRM2018_4203},
pages={4203},
file={ISMRM2018_4203.pdf:ISMRM2018_4203.pdf:PDF},
title={Image Distortion Correction via Gradient Nonlinearity Encoding at 9.4T {MRI} with Radial Ultra short {TE} ({UTE}) Sequence},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4203.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Shanshan shan and Mingyan Li and Haiwei Chen and Feng Liu and Stuart Crozier},
abstract={Radial-encoding sequences can be more sensitive to gradient trajectory deviations caused by gradient nonlinearity (GNL) than Cartesian encoding. In this work, we developed a method to alleviate image distortion caused by GNL specifically for radial-encoding. Experimental results acquired from a 9.4 T pre-clinical MRI scanner with using Ultra-short TE sequence were used to validate the proposed method.}
}
@inproceedings{ISMRM2018_4204,
annote={ISMRM2018_4204},
pages={4204},
file={ISMRM2018_4204.pdf:ISMRM2018_4204.pdf:PDF},
title={Distortion measurements empirically validate gradient model impact on diffusion weighting},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4204.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Dariya I Malyarenko and Enzo Barberi and Yuxi Pang and Julien Sénégas and Ajit Devaraj and Johannes Peeters and Teodor Stanescu and Thomas L Chenevert},
abstract={Distortion fields induced by gradient nonlinearity were measured for two channels of two MRI systems to validate vendor-provided gradient design models intended for correcting spatially nonuniform diffusion weighting. Excellent agreement was observed between the model and the empiric displacement measurements recast into first two diagonal elements of system nonlinearity tensor for both systems. The measurements were sensitive enough to detect sub-millimeter differences between nominally symmetric right-left and anterior-posterior gradients. Unexplained minor deviation from spatially symmetric design was detected for right-left gradient of both systems by diffusion and distortion measurement.}
}
@inproceedings{ISMRM2018_4205,
annote={ISMRM2018_4205},
pages={4205},
file={ISMRM2018_4205.pdf:ISMRM2018_4205.pdf:PDF},
title={Concomitant Field Compensation Improves Quality of Clinical Fast Spin Echo Images Acquired on an Asymmetric {MRI} Gradient System},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4205.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Shengzhen Tao and John Huston III and Erin Gray and Joshua Trzasko and Myung-Ho In and Yunhong Shu and Matt Bernstein},
abstract={The fast-spin-echo (FSE) acquisitions are the workhorse for routine MRI, but can be affected by concomitant field (CF)-induced phase errors. Recently, a compact 3T (C3T) MRI platform equipped with an asymmetric, high-performance gradient was developed. The asymmetric design of this gradient induces zeroth/first-order CFs (in addition to the second-order CF on conventional whole-body gradients), which can degrade image quality of FSE acquisitions. We have previously developed real-time gradient pre-emphasis and frequency shifting techniques to compensate for these additional CFs. Here, we demonstrate that these compensations significantly improve image quality of FSE using a clinical T2w-FSE protocol and a preliminary dataset.}
}
@inproceedings{ISMRM2018_4206,
annote={ISMRM2018_4206},
pages={4206},
file={ISMRM2018_4206.pdf:ISMRM2018_4206.pdf:PDF},
title={Fast eddy current characterization for the development of in-bore devices},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4206.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={David Otto Brunner and Betram Jakob Wilm and Simon Gross and Benjamin Emmanuel Dietrich and Christoph Barmet and Klaas Paul Pruessmann},
abstract={Devices operating in the magnet bore, such as coil arrays, receivers or shim inserts become ever more sophisticated as well as the employed image acquisition schemes. However, quantitative testing for their influence on the gradient switching performance is often difficult and time consuming. In this work we present a methodology for measuring, evaluating and predicting eddy current effects fast and quantitatively, employing a dynamic magnetic field camera and a framework of linear time invariant system characterization. For demonstration, standard components and several frequently applied RF coils are assessed.}
}
@inproceedings{ISMRM2018_4207,
annote={ISMRM2018_4207},
pages={4207},
file={ISMRM2018_4207.pdf:ISMRM2018_4207.pdf:PDF},
title={Extending the Simple Method for Adaptive Gradient-Delay Compensation in Radial {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4207.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Sebastian Rosenzweig and Hans Christian Martin Holme and Robin Niklas Wilke and Martin Uecker},
abstract={Lately, radial k-space trajectories have become very popular especially for fast MRI. However, radial sampling is prone to streaking artifacts caused by gradient delays. Here, we propose two extensions for a simple but powerful method that compensates gradient delays by estimating the corresponding sample shift using cross-correlation of opposed spokes. First, we show that the opposed spokes don't have to be acquired in calibration scans but can be taken directly from the actual measurements. Second, we show that it is also possible to generate synthetic spoke-pairs for gradient delay estimation.}
}
@inproceedings{ISMRM2018_4208,
annote={ISMRM2018_4208},
pages={4208},
file={ISMRM2018_4208.pdf:ISMRM2018_4208.pdf:PDF},
title={Measuring Eddy Currents Induced by Switching Gradient/Shim Currents},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4208.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Paul Chang and Sahar Nassirpour and Anke Henning},
abstract={In this work, we measured eddy currents for a very high order B
0 shim system. The eddy currents were measured using two methods: a low-resolution B
0 mapping sequence and a NMR field camera. The high temporal resolution of the field camera allowed the eddy currents to be corrected using a digital pre-emphasis setup.}
}
@inproceedings{ISMRM2018_4209,
annote={ISMRM2018_4209},
pages={4209},
file={ISMRM2018_4209.pdf:ISMRM2018_4209.pdf:PDF},
title={Using field monitoring to map and correct image distortions due to gradient nonlinearities},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4209.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ying-Hua Chu and Yi-Cheng Hsu and Fa-Hsuan Lin and Maxim Zaitsev},
abstract={We demonstrate how a field probe array can be used to measure gradient nonlinearities. Brain imaging results show that the distortion was most prominent at image voxels away from the iso-center. Compared to MRI vendor’s solution, our measurements and reconstruction could further reduce the image distortion by 35\%.}
}
@inproceedings{ISMRM2018_4210,
annote={ISMRM2018_4210},
pages={4210},
file={ISMRM2018_4210.pdf:ISMRM2018_4210.pdf:PDF},
title={Improved thermal modelling and prediction of gradient response using sensor placement guided by infrared photography},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4210.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jennifer Nussbaum and Bertram J Wilm and Benjamin E Dietrich and Klaas Paul Pruessmann},
abstract={In MRI, the dynamics of gradient fields can be predicted by assuming that the system is linear and time-invariant. However, time-invariance can be violated by thermal effects. To address this shortcoming, it has been proposed to expand the GIRF model by thermal variation parametrized with the help of temperature sensors. It has remained open how many relevant thermal degrees of freedom the system actually had and where the matching number of sensors should be placed to capture them. In the present work, we address these questions using infrared photography and principal component analysis of gradient heating. Response modelling is additionally enhanced by accelerating GIRF measurements and including cross-terms. The improvements are shown in the prediction of gradient waveforms for image reconstruction and in the effects on the images.}
}
@inproceedings{ISMRM2018_4211,
annote={ISMRM2018_4211},
pages={4211},
file={ISMRM2018_4211.pdf:ISMRM2018_4211.pdf:PDF},
title={Reduction of artefacts in Bloch-Siegert based $B_1^+$-Mapping in {CPMG}-Sequences with imperfect refocussing pulses},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4211.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Volker JF Sturm and Thomas Kampf and Lukas R Buschle and Ke Zhang and Peter M Jakob and Mirko Pham and Christian Ziener and Martin Bendszus and Sabine Heiland and Felix T Kurz},
abstract={The Bloch-Siegert-effect imprints the rf-coil’s transmission field in the phase of the acquired signal. Consequently the measured amplitude information can be used to determine other MR-Parameter. A previously published sequence based on a CPMG spin echo train uses both information pathways and allows simultaneous acquisition of $T_2$- and $B_1^+$-maps. However, the formerly proposed method produces potentially erroneous $B_1^+$-map in inhomogeneous $B_0$-fields. This work presents a method to reduce those errors by combining signal from different echoes. This allows a robust measurement of $B_1^+$-maps in inhomogeneous $B_0$-fields as present in high-field MRI with simultaneous $T_2$ quantification.}
}
@inproceedings{ISMRM2018_4212,
annote={ISMRM2018_4212},
pages={4212},
file={ISMRM2018_4212.pdf:ISMRM2018_4212.pdf:PDF},
title={Mapping B0 inhomogeneities through a self-contained analysis of single-shot 2D {MRI} data},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4212.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Gilad Liberman and Samuel F Cousin and Lucio Frydman},
abstract={Ultrafast MRI is susceptible to main field distortions ΔB
0 that affect these images’ quality and faithfulness –particularly along the low-bandwidth dimension. This work shows that these distortions can be mapped from the spatial images themselves, without requiring additional information. This information becomes available from a time-frequency analysis of the signals, after freeing them from phase-wrapping complications. This hypothesis is explained and results are demonstrated using both simulations and single-shot human brain images collected by spatiotemporal encoding (SPEN) techniques. The method opens a route to enhancing SPEN’s and EPI’s robustness to field inhomogeneities.}
}
@inproceedings{ISMRM2018_4213,
annote={ISMRM2018_4213},
pages={4213},
file={ISMRM2018_4213.pdf:ISMRM2018_4213.pdf:PDF},
title={Accurate Slice-Selective {MRI} near Metallic Implants with {FOCUSED}-x{SPEN}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4213.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Gil Farkash and Gilad Liberman and Lucio Frydman},
abstract={Metals frequently cause dramatic spatial inhomogeneities in the static field B
0. This causes severe localization errors, including slice z-displacements and slice-thickness variations. Clinically used techniques often avoid such errors by adding a phase encoding loop in z, prolonging examination times. This study examines a novel Fully refOCUSED cross-term SPatio-temporal ENcoding (FOCUSED-xSPEN) approach, as a slice selection technique for 2D MRI in the presence of metal implants. The method relies on xSPEN’s proven immunity to in-plane distortions caused by B
0 heterogeneities, to design a new excitation scheme that delivers faithful 2D slices near implants with reduced scan times.}
}
@inproceedings{ISMRM2018_4214,
annote={ISMRM2018_4214},
pages={4214},
file={ISMRM2018_4214.pdf:ISMRM2018_4214.pdf:PDF},
title={{EPI} Nyquist ghost removal by incorporating iterative k-space based phase error estimation and correction with {SPIR}iT ({PEC}-{SPIR}iT)},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4214.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yilong Liu and Mengye Lyu and Victor B. Xie and Ed X Wu},
abstract={EPI acquisition suffers from Nyquist ghost due to inconsistency between opposite readout directions. As proposed in our previous work, such inconsistency induced phase error can be removed by incorporating the Phase Error Correction with SENSE (PEC-SENSE). In this study, we employ a k-space based phase error estimation and remove the EPI Nyquist ghost by incorporating phase error correction with SPIRiT (PEC-SPIRiT). Here, a FLASH scan is used for calibration. The proposed method was evaluated using both phantom and in vivo studies, demonstrating its robustness against distortion mismatch and at high accelerations.}
}
@inproceedings{ISMRM2018_4215,
annote={ISMRM2018_4215},
pages={4215},
file={ISMRM2018_4215.pdf:ISMRM2018_4215.pdf:PDF},
title={Undersampled Spiral Magnetic Resonance Fingerprinting with Water and Fat Blurring Correction},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4215.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Teresa Nolte and Daniel Truhn and Nicolas Gross-Weege and Mariya Doneva and Peter Koken and Aaldert Elevelt and Volkmar Schulz},
abstract={In the presence of aqueous and fatty tissues, Magnetic Resonance Fingerprinting (MRF) acquisitions with spiral readout suffer from blurring artifacts. We propose to correct undersampled spiral MRF data by combining MRF with a Dixon acquisition and a subsequent conjugate phase reconstruction correction. With the proposed method, the blurring artifacts are removed from the MRF data. T
1 and T
2 parameter maps with improved homogeneity are obtained.}
}
@inproceedings{ISMRM2018_4216,
annote={ISMRM2018_4216},
pages={4216},
file={ISMRM2018_4216.pdf:ISMRM2018_4216.pdf:PDF},
title={An efficient eddy current correction method for fat quantification by bipolar readout sequence},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4216.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Chao Zou and Chuanli Cheng and Yangzi Qiao and Hao Peng and Changjun Tie and Qian Wan and Xin Liu and Hairong Zheng and Min Pan},
abstract={Multi-echo GRE sequence with bipolar readout gradients can reduce the achievable echo spacing compared to unipolar readout gradients for fat fraction (FF) quantification and has higher acquisition efficiency. The eddy current induced phase (EC-phase) in bipolar sequence corrupts the phase consistency between the echoes, making it one of the confounding factors for the accurate fat quantification. In this study, we proposed an accurate EC-phase estimation method in bipolar acquisition sequence for FF quantification. The proposed method is validated through comparing the FF quantification from the EC-phase corrected bipolar data to the well-established unipolar acquisition through phantom experiments.}
}
@inproceedings{ISMRM2018_4217,
annote={ISMRM2018_4217},
pages={4217},
file={ISMRM2018_4217.pdf:ISMRM2018_4217.pdf:PDF},
title={Fat Shift Correction in Bipolar Multi-Echo Dixon Imaging using Water-Fat Separation in k-Space},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4217.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Holger Eggers},
abstract={Fat is shifted relative to water in opposite directions in the odd and even single-echo images obtained with bipolar multi-echo sequences. Considering this effect in a water-fat separation permits suppressing associated artifacts, but has required regularization so far to cope with a locally ill-conditioned inverse problem in k-space. In this work, an alternative approach to limiting noise amplification in the water-fat separation is proposed and explored, which promises to avoid the loss of image sharpness observed with regularization.}
}
@inproceedings{ISMRM2018_4218,
annote={ISMRM2018_4218},
pages={4218},
file={ISMRM2018_4218.pdf:ISMRM2018_4218.pdf:PDF},
title={Single echo radial random alternating {TE} acquisition for B0 field inhomogeneity robust fat suppression},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4218.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Dongyeob Han and Taehwa Hong and Dong-Hyun Kim},
abstract={A single echo method which provides B0 field inhomogeneity robust fat suppression was proposed using a radial acquisition with random alternating echo time. To validate this study, simulation and in vivo experiments were performed. This technique would be useful in fat suppressed applications (e.g., MSK, liver, ...) which are required fast scan and robustness of B0 field inhomogeneity.}
}
@inproceedings{ISMRM2018_4219,
annote={ISMRM2018_4219},
pages={4219},
file={ISMRM2018_4219.pdf:ISMRM2018_4219.pdf:PDF},
title={Accelerated Imaging of Metallic Implants Using a 3D Convolutional Neural Network},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4219.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Xinwei Shi and Kathryn Stevens and Brian Hargreaves},
abstract={Multi-Spectral Imaging (MSI) methods, such as SEMAC and MAVRIC-SL, resolve metal-induced field perturbations by applying additional encoding in the spectral dimension, at the cost of increased scan time. In this work, we introduce a 3D-CNN-based reconstruction to accelerate MSI utilizing spatial-spectral features of aliasing artifacts. We demonstrate in in vivo experiments that the proposed method can accelerate MAVRIC-SL acquisitions by a factor of 3 when used alone and 17-25 when combined with parallel imaging and half-Fourier acquisition. The 3D-CNN showed significant improvement in image quality compared with parallel image and compressed sensing (PI\&CS), with negligible additional computation time.}
}
@inproceedings{ISMRM2018_4220,
annote={ISMRM2018_4220},
pages={4220},
file={ISMRM2018_4220.pdf:ISMRM2018_4220.pdf:PDF},
title={bin-{SENSE}: Accelerated {MRI} Near Metal With No Additional Hardware},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4220.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Philip K. Lee and Xinwei Shi and Daehyun Yoon and Evan G. Levine and Brian A. Hargreaves},
abstract={MAVRIC-SL suppresses artifacts induced by field inhomogeneities induced by metal, but requires increased scan time due to the acquisition of a fourth spectral dimension. We accelerate MAVRIC-SL acquisitions limited to the body coil by exploiting fieldmap information implicitly provided by the MAVRIC-SL acquisition. SENSE is applied to undo the coherent aliasing, using the spectral profiles as the spatial weights required for matrix inversion. A region growing method is applied to estimate the fieldmap and spectral profiles from uniformly undersampled data. We demonstrate 1.3x retrospective acceleration at a minimal g-factor penalty with no additional hardware requirement.}
}
@inproceedings{ISMRM2018_4221,
annote={ISMRM2018_4221},
pages={4221},
file={ISMRM2018_4221.pdf:ISMRM2018_4221.pdf:PDF},
title={A fast quality assessment and follow-up of transmit and receive coil paths},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4221.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Franck Mauconduit and Chantal Ginisty and Séverine Desmidt and Séverine Roger and Lionel Allirol and Lucie Hertz-Pannier and Alexandre Vignaud},
abstract={To operate a MRI system within the best conditions of reproducibility, Quality Assurance (QA) is mandatory to prevent defects and to detect abnormalities in subparts of the system. When using third-party or home-made coils, it is particularly important to guaranty stability of transmit and receive coil paths. For this purpose, we implemented a fast and user-friendly integrated assessment and follow-up to prevent or quickly detect failures.}
}
@inproceedings{ISMRM2018_4222,
annote={ISMRM2018_4222},
pages={4222},
file={ISMRM2018_4222.pdf:ISMRM2018_4222.pdf:PDF},
title={Interlaced Total Variation for Gibbs Artifact Reduction in the Presence of Zero Padding},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4222.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Kaixuan Zhao and Zhongbiao Xu and Feng Huang and Yingjie Mei and Yanqiu Feng},
abstract={The Gibbs artifact can be effectively eliminated by searching the local sub-voxel shifts (LSS) that minimize total variations, but it is only applicable to images reconstructed without zero padding. This work extends the LSS method to Gibbs artifact reduction in the presence of zero padding by introducing an interlaced total variation (iTV). The simulation and in vivo experimental results demonstrate that the proposed method can effectively remove Gibbs artifact in the presence of zero padding.
}
}
@inproceedings{ISMRM2018_4223,
annote={ISMRM2018_4223},
pages={4223},
file={ISMRM2018_4223.pdf:ISMRM2018_4223.pdf:PDF},
title={In-vivo water T2 mapping in tissues containing water and fat using a T2-prepared 3D Dixon {TSE} sequence and a pre-calibrated fat spectrum model},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4223.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Dominik Weidlich and Maximilian N. Diefenbach and Sarah Schlaeger and Andreas Hock and Stefan Ruschke and Dimitrios C. Karampinos},
abstract={Water T2 is seen as a potential biomarker for brown adipose tissue presence and as a marker of disease activity in patients with neuromuscular disorders. Measuring water T2 in tissues containing water and fat is challenging due to the need to separate the effects of water and fat during T2 quantification. The present work proposes an adiabatic T2 prepared 3D TSE Dixon sequence in combination with a novel DIXON water-fat decomposition method and demonstrates in vivo its feasibility to measure water T2 of brown adipose tissue in the supraclavicular fossa.}
}
@inproceedings{ISMRM2018_4224,
annote={ISMRM2018_4224},
pages={4224},
file={ISMRM2018_4224.pdf:ISMRM2018_4224.pdf:PDF},
title={3D {CSI}-Electrical Properties Tomography},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4224.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Reijer L. Leijsen and Wyger M. Brink and Cornelis A.T. van den Berg and Andrew G. Webb and Rob F. Remis},
abstract={The goal of Contrast Source Inversion – Electrical PropertiesTomography is to iteratively reconstruct the conductivity and permittivity of tissue from $B_1^+$ field data. Up to now, this method has only been implemented in two dimensions. Here we demonstrate a proof-of-principle of a three-dimensional (3D) extension, thereby potentially turning CSI-EPT into a volumetric EPT technique. We present the basic 3D CSI-EPT equations, illustrate the performance of 3D CSI-EPT for realistic 3D body models and show that accurate reconstructions are obtained even at tissue boundaries. The influence of the magnitude of the electric field on the reconstructions is also discussed.}
}
@inproceedings{ISMRM2018_4225,
annote={ISMRM2018_4225},
pages={4225},
file={ISMRM2018_4225.pdf:ISMRM2018_4225.pdf:PDF},
title={Inversion-Recovery {UTE} multispoke sequence: comparison of two excitation schemes},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4225.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Lucas Soustelle and Julien Lamy and François Rousseau and Jean-Paul Armspach and Paulo Loureiro de Sousa},
abstract={Inversion-Recovery UTE sequences have been used to highlight and quantify short-T2 structures. Covering a 3D volume remains time-consuming and a trade-off often needs to be found between k-space undersampling and acceptable appearing streaking artifacts. As such, acquiring several radial spokes within a single repetition time represents a supplementary sequence acceleration possibility. In this work, we propose to quantify the short-T2 signal difference between a constant and an optimized variable flip angle strategy in a multispoke acquisition module and within a long-T2 suppression condition in vitro.}
}
@inproceedings{ISMRM2018_4226,
annote={ISMRM2018_4226},
pages={4226},
file={ISMRM2018_4226.pdf:ISMRM2018_4226.pdf:PDF},
title={On the use of frequency modulated pulses in sat-{UTE}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4226.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Lucas Soustelle and Ericky Caldas de A. Araujo and François Rousseau and Jean-Paul Armspach and Pierre G. Carlier and Paulo Loureiro de Sousa},
abstract={Conventional slice selection in 2D-UTE sequences is challenging as eddy currents and gradient non-idealities make difficult to achieve an appropriate slice selection and a minimum TE. The sat-UTE sequence proposes a simplification that separates slice selection from excitation, ensuring an easily implementable 2D-UTE sequence. The selection part was originally proposed with a short gaussian pulse, constraining slice selectivity to a gaussian profile and demanding exceedingly high RF power for ensuring efficient saturation. In this work, we propose an alternative implementation using low-peak-amplitude and selective quadratic phase pulses for slice saturation, providing an efficient and sharp short-T2 slice selection in sat-UTE.}
}
@inproceedings{ISMRM2018_4227,
annote={ISMRM2018_4227},
pages={4227},
file={ISMRM2018_4227.pdf:ISMRM2018_4227.pdf:PDF},
title={Fast High-Resolution Endodontic {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4227.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Philipp Madörin and Matthias Weigel and Thomas Connert and Sebastian Kühl and Oliver Bieri},
abstract={The aim of this study was to explore standard MRI hardware and sequences as an alternative radiation-free modality to Cone Beam Computer Tomography for imaging the dental root canals rapidly and with high-resolution for the planning and guidance of the bur to the root canal orifice in combination with an intraoral surface scan.}
}
@inproceedings{ISMRM2018_4228,
annote={ISMRM2018_4228},
pages={4228},
file={ISMRM2018_4228.pdf:ISMRM2018_4228.pdf:PDF},
title={Accelerated Spin Echo Imaging using Simultaneous Spin-Echo Refocusing in conjunction with a {PINS} Refocusing Pulse},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4228.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Francesco Padormo and Rebecca Emily Feldman and Priti Balchandani},
abstract={We proposed a novel alternative to the Turbo Spin Echo. It combines ideas from the Simultaneous Spin-Echo Refocusing method with PINS pulse design to result in a low SAR acquisition.}
}
@inproceedings{ISMRM2018_4229,
annote={ISMRM2018_4229},
pages={4229},
file={ISMRM2018_4229.pdf:ISMRM2018_4229.pdf:PDF},
title={Rapid multi-inversion {SMS}-{EPI} integrated with gradient-echo, spin-echo and diffusion-weighted {EPI} acquisitions},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4229.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Daniel J Park and Thomas Witzel and Ilana Leppert and Yi-Fen Yen and Qiuyun Fan and Christine Tardif and Jonathan Polimeni},
abstract={Recently inversion-recovery techniques have been combined with EPI in an efficient scheme in which a non-selective inversion is merged with a slice reordering scheme, providing rapid quantitative T1 maps. Here we merge this approach with several recent EPI technologies, including SMS-EPI and several image contrasts including T2-, T2* and diffusion weighted acquisitions. Not only does this allow the efficient combination of multiple contrasts but it opens the door to a rapid, all-EPI examination.}
}
@inproceedings{ISMRM2018_4230,
annote={ISMRM2018_4230},
pages={4230},
file={ISMRM2018_4230.pdf:ISMRM2018_4230.pdf:PDF},
title={A Gradient Spoiled Spin-Echo Sequence for Simultaneously Measuring B1+, B0, T1, T2, T2* and Velocity of a Two-Dimensional Slice},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4230.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Nicholas Dwork and Adam B Kerr and John M Pauly},
abstract={A single sequence is presented that quantifies several parameters simultaneously of a two-dimensional slice.}
}
@inproceedings{ISMRM2018_4231,
annote={ISMRM2018_4231},
pages={4231},
file={ISMRM2018_4231.pdf:ISMRM2018_4231.pdf:PDF},
title={Evaluating {RF} and gradient spoiling in {MPRAGE} and {MP}2{RAGE} using novel, efficient algorithms for 3D extended phase graph and ideal-spoiling models},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4231.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={M. Dylan Tisdall},
abstract={To optimize spoiling efficiency, we evaluate several design choices for RF- and gradient-spoiling in MPRAGE-type sequences. Optimization is performed using two efficient algorithms, one for the ideal-spoiling condition and one for a 3D extended phase graph model that realistically captures spoiling effects. We used novel implementations of both algorithms, with publicly available source, that attempt to maximize computational efficiency. Our results suggest possible avenues for improving spoiling in MPRAGE-type sequences.}
}
@inproceedings{ISMRM2018_4232,
annote={ISMRM2018_4232},
pages={4232},
file={ISMRM2018_4232.pdf:ISMRM2018_4232.pdf:PDF},
title={Description of the off-resonance dependency in slice-selective {FISP} {MRF}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4232.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Gregor Körzdörfer and Bartosz Guzek and Yun Jiang and Josef Pfeuffer and Bernhard Hensel and Peter Speier and Mathias Nittka},
abstract={In Magnetic Resonance Fingerprinting (MRF), quantitative parameter maps are generated by matching pseudo randomly generated MR signals with a precalculated dictionary. A common implementation of MRF is based on an unbalanced SSFP (FISP) sequence in combination with a slice-selective excitation. In this work, we demonstrate its sensitivity to off-resonances in specific configurations, investigate the underlying spin physics and derive according mitigation approaches.}
}
@inproceedings{ISMRM2018_4233,
annote={ISMRM2018_4233},
pages={4233},
file={ISMRM2018_4233.pdf:ISMRM2018_4233.pdf:PDF},
title={m{GRE} and {TFE} based cardiac {SWI} at 3.0 T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4233.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Xiaoqi Wang},
abstract={In this work, a 3.0 T multiple echo sequence was developed for cardiac scans and a feasibility study was carried to assess whether susceptibility-weighted imaging (SWI) provides image contrast for the detection of myocardium disease. Currently collected images indicates that cardiac SWI at 3.0 T provides a prominent option for detecting myocardial abnormality, while further optimization to obtain sensitivity and accuracy is needed.}
}
@inproceedings{ISMRM2018_4234,
annote={ISMRM2018_4234},
pages={4234},
file={ISMRM2018_4234.pdf:ISMRM2018_4234.pdf:PDF},
title={Imaging cardiac fat by chemical shift encoded {MRI} application in {CINE} format at 3 T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4234.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Xiaoqi Wang},
abstract={Ectopic fat deposition impacts cardiac health and non-invase quantification is required. In this work, a chemical shift encoded MRI is designed for cardiac applications. Images of Proton density fat fraction (PDFF) water (W) and fat(F) and T2* were generated for each frame of cardiac motion, formed CINE movies for cardiac cycles. The novel sequence was flexible in clinical applications with short acquisition time and made sensitive findings in this research.}
}
@inproceedings{ISMRM2018_4235,
annote={ISMRM2018_4235},
pages={4235},
file={ISMRM2018_4235.pdf:ISMRM2018_4235.pdf:PDF},
title={{AC} magnetic sensing using the {SIRS} effect combined with b{SSFP} at ultra-low field},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4235.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Bragi Sveinsson and Neha Koonjoo and Bo Zhu and Thomas Witzel and Matthew Rosen},
abstract={Direct detection of neuronal currents has long been a goal within MRI, with the aim of improving upon the spatial and temporal resolution of BOLD fMRI. So far, good results have been shown in phantoms but detection in vivo has proven difficult. A promising current detection technique is Stimulus-Induced Rotary Saturation (SIRS), but the BOLD signal can contaminate SIRS measurements, possibly explaining inconclusive in vivo results so far. A new sequence was developed and tested in an ultra-low-field (ULF) regime (6.5 mT) where paramagnetic effects such as BOLD are reduced and is more suited for SIRS measurements in vivo.}
}
@inproceedings{ISMRM2018_4236,
annote={ISMRM2018_4236},
pages={4236},
file={ISMRM2018_4236.pdf:ISMRM2018_4236.pdf:PDF},
title={Reducing Blurring while Controlling Contrast in Abdominal Imaging with Variable Flip Angle Single Shot Fast Spin Echo},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4236.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={LI Zhao and Manuel Taso and Daniel V Litwiller and David C. Alsop},
abstract={Single-shot fast spin echo is used clinically to provide fast, motion-robust abdominal images. However, signal decay along the echo train results in blurred images. Our previous work on optimal variable flip angle design demonstrated improved SNR on brain imaging. Here, we extend this framework to show simultaneous T2 blurring and contrast control in abdominal imaging with single-shot fast spin echo.}
}
@inproceedings{ISMRM2018_4237,
annote={ISMRM2018_4237},
pages={4237},
file={ISMRM2018_4237.pdf:ISMRM2018_4237.pdf:PDF},
title={Fast Measurement of B1+ using the {NO}2{RAGE} pulse sequence},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4237.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Riccardo Metere and Tobias Lenich and Kerrin J. Pine and Harald E. Möller},
abstract={The knowledge of the spatial distribution of the transmit field of the coil, B
1+, is essential in a number of MRI applications, particularly at higher field strength. SA2RAGE is a recently developed technique for B
1+ mapping, derived from the MP2RAGE scheme. The sensitivity to B
1+ is obtained from a preparation pulse and optimized delays between block gradient acquisitions. Here, we propose a much faster (but otherwise comparable) method, referred to as NO2RAGE, where the B
1+ sensitivity is obtained by omitting the preparation, nullifying the delays and adjusting the other sequence parameters. The technique compares favorably against other in vivo methods.}
}
@inproceedings{ISMRM2018_4238,
annote={ISMRM2018_4238},
pages={4238},
file={ISMRM2018_4238.pdf:ISMRM2018_4238.pdf:PDF},
title={Efficient imaging of Rabi modulated trajectories using balanced Steady-State Driven Trajectory (b{SSDT}) imaging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4238.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={James C Korte and Bahman Tahayori and Peter M Farrell and Yasmin Blunck and Leigh A Johnston},
abstract={We propose an efficient technique to image localised steady-state trajectories, termed balanced Steady-State Driven Trajectory (bSSDT) imaging and implement the protocol to investigate the properties of Rabi modulated steady-state trajectories. In bSSDT imaging, a sequence of points on the voxel-wise steady-state trajectory is acquired. The resultant 4-D data offers a potentially rich source of information about the underlying tissue properties. The proposed imaging technique is a pseudo-continuous excitation version of balanced steady-state free precession (bSSFP) imaging, with relaxation of the magnetisation to the equilibrium steady-state in bSSFP replaced by control of the magnetisation to a steady-state trajectory in bSSDT.}
}
@inproceedings{ISMRM2018_4239,
annote={ISMRM2018_4239},
pages={4239},
file={ISMRM2018_4239.pdf:ISMRM2018_4239.pdf:PDF},
title={Fast {BLADE} with variable flip angle},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4239.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yuyu Wang and Le Zhang and Muhammed Labeeb and Dehe Weng},
abstract={An effective approach with variable flip angle to speed up BLADE acquisition is proposed for general MR imaging. It improved the efficiency of BLADE by enlarging the width of one blade. The image quality is comparable with that of conventional BLADE method.}
}
@inproceedings{ISMRM2018_4240,
annote={ISMRM2018_4240},
pages={4240},
file={ISMRM2018_4240.pdf:ISMRM2018_4240.pdf:PDF},
title={Velocity Sensitivity of Inner-Volume Cardiac Echo Planar Imaging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4240.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ahsan Javed and Terrence Jao and Krishna S. Nayak},
abstract={Inner volume echo planar imaging (IV-EPI) is feasible and useful for cardiac diffusion tensor imaging and arterial spin labelling . IV-EPI inherently provides velocity-selective saturation caused by the crusher gradients around the 180º refocusing-pulse. In this study, we characterize this velocity-dependent effect on myocardial signal in systolic and diastolic cardiac phases. We find that a simple velocity distribution model fits the data well and that the data from our experiments allows us to make recommendation for designing gradients to avoid myocardial signal loss for diastolic and systolic IV-EPI imaging.}
}
@inproceedings{ISMRM2018_4241,
annote={ISMRM2018_4241},
pages={4241},
file={ISMRM2018_4241.pdf:ISMRM2018_4241.pdf:PDF},
title={Improving Image Quality of A Spiral T1 Spin-Echo Sequence},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4241.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Zhiqiang Li and Melvyn B Ooi and Dinghui Wang and James G Pipe},
abstract={Cartesian SE is widely used for T1 imaging, but is slow and often susceptible to flow artifacts. A spiral T1SE technique has been proposed for rapid T1 imaging with minimal flow artifacts. However, inconsistent through-plane signal has been observed with certain protocols. In this work we investigate the root causes and propose a combined RF/gradient chopping scheme to minimize this inconsistency and improve the T1 contrast. The improvement was demonstrated with phantom and volunteer data.}
}
@inproceedings{ISMRM2018_4242,
annote={ISMRM2018_4242},
pages={4242},
file={ISMRM2018_4242.pdf:ISMRM2018_4242.pdf:PDF},
title={Optimized parameters for {MP}2{RAGE} images on 7-T {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4242.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Uksu Choi and Hirokazu Kawaguchi and Yuichiro Matsuoka and Tobias Kober and Ikuhiro Kida},
abstract={The MP2RAGE sequence at ultra-high magnetic fields can be advantageous for investigation of microstructural changes because of reduced B1 inhomogeneity and images with different contrasts (uniform (UNI), T1 and fluid and white matter suppression (FLAWS)). In this study, we used several evaluative methods to optimize the inversion times and flip angles for UNI, T1 and FLAWS images of the MP2RAGE sequence at 7 T. We found the optimized inversion times with flip angles for UNI and T1 images, but different parameters for FLAWS images. The results suggested that different parameters of MP2RAGE at 7 T should be applied for different contrast types.}
}
@inproceedings{ISMRM2018_4243,
annote={ISMRM2018_4243},
pages={4243},
file={ISMRM2018_4243.pdf:ISMRM2018_4243.pdf:PDF},
title={B1- and Fat-Corrected T1 Mapping Using Chemical-Shift Encoded {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4243.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Nathan T Roberts and Timothy J Colgan and Xiaoke Wang and Diego Hernando and Scott B Reeder},
abstract={Spatially varying B
1 inhomogeneities and fat content are well known to be confounders of quantitative T
1 mapping that use multi flip angle techniques. Separate B
1 calibration maps can be acquired to correct flip angle errors cause by B
1 inhomogeneities, but this requires an additional acquisition. In this work we consider an alternative approach that acquires variable flip angles and variable repetition times and simultaneously estimates B
1 inhomogeneity, T
1, fat-fraction and R
2*. The feasibility and noise performance of this approach are evaluated using theoretical Cramer-Rao Lower Bound analysis and simulations. Our results demonstrate that this approach is feasible, but suffers from relatively poor noise performance at typical acquisition parameters.}
}
@inproceedings{ISMRM2018_4244,
annote={ISMRM2018_4244},
pages={4244},
file={ISMRM2018_4244.pdf:ISMRM2018_4244.pdf:PDF},
title={T2 measurement in {SE}-{WMRI} fast spin echo imaging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4244.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Edzer Lienson Wu and Po-Wei Cheng and Tzi-Dar Chiueh and Jyh-Horng Chen},
abstract={To investigate the contrast in SE-WMRI spin echo imaging, we measured five tubes of SPIO solution with various concentrations using standard and SE-WMRI Multi-Slice-Multi-Echo (MSME) sequence. T2 relaxation times were then calculated based on the 16 acquired images per scan. Results show that with a 1.4-fold acceleration, the T2 relaxation time of SE-WMRI MSME remains the same within the error bar as standard imaging.}
}
@inproceedings{ISMRM2018_4245,
annote={ISMRM2018_4245},
pages={4245},
file={ISMRM2018_4245.pdf:ISMRM2018_4245.pdf:PDF},
title={On the Analysis of {EPI} Phase Correction with Small Tip Angle Excitation to reduce minimum required {TE}: Application to Whole-Brain Submillimetre-Resolution f{MRI} at 3T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4245.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Seong Dae Yun and N. Jon Shah},
abstract={EPI has been widely used for fMRI due to its relatively fast imaging speed. However, as one of its drawbacks, ghost artefacts need to be corrected. In the community, an approach that utilises three non-phase encoded navigator echoes is commonly used for the correction. Although this scheme is quite effective, as the matrix size increases for high-resolution imaging the navigator echoes constitute a significant contribution in increasing the minimum required TE. To overcome this issue, this work employs an alternative navigator echo scheme. Here, its performance was analysed and whole-brain submillimetre-resolution fMRI (0.75 × 0.75 mm
2) was demonstrated at 3T.}
}
@inproceedings{ISMRM2018_4246,
annote={ISMRM2018_4246},
pages={4246},
file={ISMRM2018_4246.pdf:ISMRM2018_4246.pdf:PDF},
title={Generation of Arbitrary Spectral Profiles using Orthonormal Basis Combinations of b{SSFP} {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4246.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Michael Mendoza and Nicholas McKibben and Neal Bangerter},
abstract={We present a technique for generating an arbitrary spectral profile by using multiple-acquisition bSSFP. Multiple phase-cycled bSSFP images with increasing TRs were acquired and Gram-Schmidt orthogonalization was applied to spectral basis functions to generate an orthonormal basis. This generated orthonormal basis was used to approximate an arbitrary spectral profile by using linear combinations of the calculated basis functions. A variety of spectral functions were simulated and used as a template to approximate spectral profiles in water and fat phantoms.
}
}
@inproceedings{ISMRM2018_4247,
annote={ISMRM2018_4247},
pages={4247},
file={ISMRM2018_4247.pdf:ISMRM2018_4247.pdf:PDF},
title={Simultaneous Observation of Two Paramagnetic {MRI} Contrast Agents via Dynamic T1 and T2 Mapping with Magnetic Resonance Fingerprinting: Initial In Vivo Results},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4247.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Christian E Anderson and Yuning Gu and Mette Johansen and He Hu and Yun Jiang and Michael Kavran and Bernadette Erokwu and Susann Brady-Kalnay and Nicole Steinmetz and Xin Yu and Mark Griswold and Chris Flask},
abstract={In this work simultaneous T1 and T2 mapping via MR Fingerprinting was used to observe the distribution of dysprosium and gadolinium MRI contrast agents in a mouse tumor model. Changes from baseline in T1 and T2 were observed using each agent alone and an increased effect was seen when agents were used in combination. Additionally, a decrease in the dysprosium dose lead to a reduction in the level of T1 and T2 enhancement observed. These results indicate that MRF might be able to be used to track multiple MRI contrast agents in vivo.}
}
@inproceedings{ISMRM2018_4248,
annote={ISMRM2018_4248},
pages={4248},
file={ISMRM2018_4248.pdf:ISMRM2018_4248.pdf:PDF},
title={Optimization of the Flow Encoding Pattern under Consideration of Spatio-Temporal Velocity Gradients in flow-{MR} Fingerprinting},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4248.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Sebastian Flassbeck and Simon Schmidt and Mark E. Ladd and Sebastian Schmitter},
abstract={It has been shown that the quantification of blood flow velocities through the use of bipolar gradients is possible within the MRF framework, called flow-MRF. In this work, we investigate four different flow encoding patterns for flow-MRF and analyze their impact on flow quantification. Finallywe presentan optimized pattern.}
}
@inproceedings{ISMRM2018_4249,
annote={ISMRM2018_4249},
pages={4249},
file={ISMRM2018_4249.pdf:ISMRM2018_4249.pdf:PDF},
title={Time efficient whole-brain coverage in Magnetic Resonance Fingerprinting using echo-planar imaging, slice-interleaving and simultaneous multi-slice imaging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4249.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Benedikt Rieger and Mehmet Akçakaya and Lothar Schad and Sebastian Weingärtner},
abstract={Magnetic resonance fingerprinting (MRF) is a promising method for simultaneous multi-parameter quantification. However, spatial coverage is limited in the original method due to the rapid image readout and the balanced sequence design. The aim of this study is to enable time-efficient volumetric coverage in Cartesian MRF-EPI for whole-brain quantification in clinically acceptable scan times. A slice-interleaved acquisition is shown to offer quantification precision comparable to single-slice measurements in a fraction of the measurement time. By combining this with simultaneous multi-slice imaging, whole-brain coverage with 40 slices was achieved in one minute, resulting in high quality T
1 and T
2* maps.}
}
@inproceedings{ISMRM2018_4250,
annote={ISMRM2018_4250},
pages={4250},
file={ISMRM2018_4250.pdf:ISMRM2018_4250.pdf:PDF},
title={From phantoms to patients: Paving the way for {MRF} in clinical practice},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4250.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Marcel Gratz and Jasmin Jäger and Mathias Nittka and Stephan Kannengiesser and Josef Pfeuffer and Gregor Koerzdoerfer and Rainer Kirsch and Florian Meise and Harald H. Quick and Vikas Gulani and Mark Griswold and Michael Forsting and Lale Umutlu},
abstract={This study puts the focus on estimating the stability of MRF data in phantoms, volunteers and patients and investigates the options to integrate MRF into routine clinical workflows. The phantom and in-vivo scans yielded consistent and reproducible results throughout different scan days. Thus, MRF enables a fast and reliable generation of quantitative data in vivo and, along with appropriate reference values, has the potential to improve diagnostics in neuroimaging.}
}
@inproceedings{ISMRM2018_4251,
annote={ISMRM2018_4251},
pages={4251},
file={ISMRM2018_4251.pdf:ISMRM2018_4251.pdf:PDF},
title={Doped Polyvinylpyrrolidone Solutions for Tunable T1, T2 and {ADC} in Multiparametric Phantoms},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4251.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Michael A Boss and Yun Jiang and Stephen E Russek and Mark A Griswold},
abstract={A multiparametric phantom for quantitative MRI and magnetic resonance fingerprinting was developed. Solutions of PVP were used to tune the apparent diffusion coefficient (ADC) and then doped with Mn to control T
1 and T
2. The addition of Mn did not affect the ADC, but did significantly shorten T
1 and T
2, demonstrating the potential of independently tuning relaxation times and ADC.}
}
@inproceedings{ISMRM2018_4252,
annote={ISMRM2018_4252},
pages={4252},
file={ISMRM2018_4252.pdf:ISMRM2018_4252.pdf:PDF},
title={Diffusion Propagator Formalism in Bloch Equation Simulation of Magnetic Resonance Fingerprinting},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4252.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Shota Hodono and Yun Jiang and Naren Nallapareddy and Vikas Gulani and Mark Griswold},
abstract={By considering spin diffusion as a random walk process and introducing a Gaussian probability function to the Bloch equation, a diffusion propagator was developed, which allows diffusion to be accounted for in magnetic resonance fingerprinting (MRF) simulations. In this study, signal intensities generated by Bloch simulations with the diffusion propagator were compared with theoretical values for the diffusion-weighted spin echo sequence. Additionally, the diffusion propagator approach was applied to the MRF fast imaging with steady-state precession sequence and the resulting signal evolution was qualitatively compared with that generated by the Extended Phase Graphs method.}
}
@inproceedings{ISMRM2018_4253,
annote={ISMRM2018_4253},
pages={4253},
file={ISMRM2018_4253.pdf:ISMRM2018_4253.pdf:PDF},
title={Normative T1 and T2 relaxation times and measurement repeatability of abdomen organs at 3T using 2D {MR} Fingerprinting},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4253.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Sanjay Sridaran and Ananya Panda and Yong Chen and Jesse Hamilton and Shivani Pahwa and Katherine Wright and Yun Jiang and Joshua Batesole and Mark Griswold and Nicole Seiberlich and Vikas Gulani},
abstract={T
1 and T
2 mapping of abdominal organs provides valuable information for characterization of abdominal pathologies, but is limited by technical difficulties. Previous work has demonstrated the utility of MR Fingerprinting (MRF) for abdominal relaxometry. However, there are still limited normative data for different abdominal organs. In this study, 2D MRF was applied to 22 subjects to establish normative values for abdominal organs at 3T and assess repeatability. Our results demonstrated a good agreement with the literature and repeatability of the measurement. The values obtained in this study can also serve as a reference for future clinical studies.}
}
@inproceedings{ISMRM2018_4254,
annote={ISMRM2018_4254},
pages={4254},
file={ISMRM2018_4254.pdf:ISMRM2018_4254.pdf:PDF},
title={Dictionary free anatomical segmentation of Magnetic Resonance Fingerprinting brain data with Independent Component Analysis},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4254.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Rasim Boyacioglu and Dan Ma and Debra McGivney and Louisa Onyewadume and Ozden Kilinc and Chaitra Badve and Vikas Gulani and Mark Griswold},
abstract={Magnetic Resonance Fingerprinting signal evolutions are sensitized to certain tissue properties during data acquisition. The matching step can be suboptimal due to dictionary limitations or tissue related constraints (e.g. partial volume, magnetization exchange). Here, we propose to apply Independent Component Analysis (ICA) to 4D MRF data after image reconstruction without explicit dictionary matching for tissue characterization, lifting the requirement for a relaxation model. ICA of whole brain MRF data segments the brain into multiple components with single tissue types such as gray matter, white matter and CSF for healthy subjects and also tumor in the case of glioblastoma patients.}
}
@inproceedings{ISMRM2018_4255,
annote={ISMRM2018_4255},
pages={4255},
file={ISMRM2018_4255.pdf:ISMRM2018_4255.pdf:PDF},
title={Prostate cancer tissue characterization with spatio-temporal analysis of Magnetic Resonance Fingerprinting data},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4255.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Rasim Boyacioglu and Ananya Panda and Yun Jiang and Debra McGivney and Vikas Gulani and Mark Griswold},
abstract={Multiple tissue properties (T1, T2, diffusion, etc.) and system parameters can be acquired simultaneously with Magnetic Resonance Fingerprinting (MRF). The dictionary formation and matching steps may be confounded by the lack of certain tissue properties (e.g. magnetization exchange) in the dictionary and thus, the differentiation of tissues of interest may be suboptimal even though variable MRF signal evolutions set them apart. Here, as a dictionary-free alternative, spatio-temporal analysis of MRF time series is proposed for tissue characterization. Independent Component Analysis (ICA) based correlation analysis of prostate MRF data can distinguish between healthy and cancer tissue without explicit dictionary matching.}
}
@inproceedings{ISMRM2018_4256,
annote={ISMRM2018_4256},
pages={4256},
file={ISMRM2018_4256.pdf:ISMRM2018_4256.pdf:PDF},
title={Magnetic Resonance Fingerprinting ({MRF}) Can Reveal Microstructural Variations in the Brain Gray Matter},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4256.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Shahrzad Moeiniyan Bagheri and Viktor Vegh and David C Reutens},
abstract={The importance of creating accurate anatomical maps of the human brain has motivated the development of in vivo, observer-independent and reproducible mapping methods that account for inter-individual variation. However, a) whole brain coverage and b) a multi-modal approach that accounts for the combined effects of all microscale tissue properties has yet to be developed. To bridge this gap, we propose a statistical feature-based residual analysis framework that makes use of unique tissue-specific MRF signals after taking account of T1 and T2* effects. In four cortical areas of six participants, this approach showed consistent similarity measurements between regions, indicating that MRF signals contain information about micro-level tissue properties.}
}
@inproceedings{ISMRM2018_4257,
annote={ISMRM2018_4257},
pages={4257},
file={ISMRM2018_4257.pdf:ISMRM2018_4257.pdf:PDF},
title={{MRF}-FrM: A Preliminary Study on Improving Magnetic Resonance Fingerprinting Using Fractional-order Models},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4257.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Haifeng Wang and Leslie Ying and Xin Liu and Hairong Zheng and Dong Liang},
abstract={Magnetic resonance fingerprinting (MRF) is an exceptional promise for simultaneous quantification of T1 and T2 maps, based on the traditional Bloch equation formalism of MR and numerous readouts. In this work, a Fractional-order model of the Bloch equations is applied to create the dictionary of the T1 and T2 maps used in MRF. The simulations show that the proposed method can improve the evaluation accuracy of the T1 and T2 maps comparing with the conventional MRF methods with the traditional first-order model of the Bloch simulation.}
}
@inproceedings{ISMRM2018_4258,
annote={ISMRM2018_4258},
pages={4258},
file={ISMRM2018_4258.pdf:ISMRM2018_4258.pdf:PDF},
title={Hybrid-State Free Precession for Measuring Magnetic Resonance Relaxation Times},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4258.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jakob Assländer and Daniel K Sodickson and Riccardo Lattanzi and Martijn Cloos},
abstract={This work analyzes the spin physics in steady-state free precession sequences modified to smoothly vary sequence parameters, as suggested in MR Fingerprinting. We arrive at the conclusion that a transient state develops only in one direction, while the magnetization in the other two dimensions transitions adiabatically between steady states. We provide solutions of the Bloch Equations for this hybrid state and demonstrate the superior T
1- and T
2-encoding performance of the hybrid state compared to the steady state.}
}
@inproceedings{ISMRM2018_4259,
annote={ISMRM2018_4259},
pages={4259},
file={ISMRM2018_4259.pdf:ISMRM2018_4259.pdf:PDF},
title={{DICTIONARY}-{FREE} {MR} {FINGERPRINTING} {PARAMETER} {ESTIMATION} {VIA} {INVERSE} {REGRESSION}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4259.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Fabien Boux and Florence Forbes and Julyan Arbel and Emmanuel L. Barbier},
abstract={MR Fingerprint requires an exhaustive search in a dictionary, which even for moderately sized problems, becomes costly and possibly intractable. In this work, we propose an alternative approach: instead of an exhaustive search for every signal, we use the dictionary to learn the functional relationship between signals and parameters. This allows the direct estimation of parameters without the need of searching through the dictionary. The comparison between a standard grid search and the proposed approach suggest that MR Fingerprinting could benefit from a regression approach to limit dictionary size and fasten computation time.}
}
@inproceedings{ISMRM2018_4260,
annote={ISMRM2018_4260},
pages={4260},
file={ISMRM2018_4260.pdf:ISMRM2018_4260.pdf:PDF},
title={Fast parameter mapping at 7T with {SSFP} {MR} Fingerprinting using 3D radial trajectories},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4260.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Guido Buonincontri and Pedro A Gómez and Matteo Cencini and Giada Fallo and Laura Biagi and Rolf F Schulte and Michela Tosetti},
abstract={When using ultra-high field MRI scanners (UHF, B0>= 7T), quantitative imaging is challenging due to B0 and B1+ non-uniformities. Magnetic resonance fingerprinting (MRF) represents a great opportunity for quantitative imaging at UHF as it can estimate these effects at the same time of the parameters of interest. Here, we demonstrate in vivo at 7T a novel 3D MRF approach based on a three-dimensional radial k-space acquisition, estimating M0, T1, T2 and B1+ simultaneously in 5 minutes.}
}
@inproceedings{ISMRM2018_4261,
annote={ISMRM2018_4261},
pages={4261},
file={ISMRM2018_4261.pdf:ISMRM2018_4261.pdf:PDF},
title={{MORE}-{MRF}: Towards Motion Resolved Cardiac Multi-Parametric Mapping with Magnetic Resonance Fingerprinting},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4261.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Olivier Jaubert and Gastao Cruz and Torben Schneider and Rene Botnar and Daniel Rueckert and Claudia Prieto},
abstract={Magnetic Resonance Fingerprinting (MRF) estimates multi-parametric maps simultaneously with short acquisition times. Cardiac MRF has been recently proposed to quantify myocardial T
1 and T
2 maps for 2D single-phase cardiac imaging. This ECG-triggered breath–hold approach provides a single-phase cardiac image and uses a non-continuous (segmented) acquisition. Here we sought to investigate myocardial MRF at multiple cardiac phases from a continuous acquisition, which could simultaneously provide cardiac function and quantitative tissue characterisation. The proposed approach was evaluated in simulations and healthy subjects, considering eight cardiac phases per cycle.}
}
@inproceedings{ISMRM2018_4262,
annote={ISMRM2018_4262},
pages={4262},
file={ISMRM2018_4262.pdf:ISMRM2018_4262.pdf:PDF},
title={Unbalanced Steady-State Free Precession {MR} Fingerprinting with Simultaneous Fat Signal Fraction, T1, T2 and B0 Estimation},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4262.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jason Ostenson and Bruce M. Damon and E. Brian Welch},
abstract={Unbalanced steady-state free precession MR fingerprinting (uSSFP-MRF) may be used to quantify fat signal as well as water T1 and T2, but is subject to off-resonance (B0) and blurring. We propose a variable echo time uSSFP and post-processing method that estimates fat signal fraction, water T1 and T2 and B0 within a single sequence. The method is tested in phantoms and in vivo. Preliminary results indicate the proposed method provides sharp fat fraction maps that account for chemical-shift and B0 effects that normally lead to blurring, as well as generate water-only T1 and T2 maps.}
}
@inproceedings{ISMRM2018_4263,
annote={ISMRM2018_4263},
pages={4263},
file={ISMRM2018_4263.pdf:ISMRM2018_4263.pdf:PDF},
title={Multiband Multi-slab Magnetic Resonance Fingerprinting Using Overlapping Slabs and Temporal-Sharing Reconstruction},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4263.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Di Cui and Hing-Chiu Chang and Queenie Chan and Xiaoxi Liu and Edward S Hui},
abstract={Magnetic Resonance Fingerprinting (MRF) is a novel and rapid technique to quantify multiple MR parameters and single-slab MRF was later developed for better slice coverage. In this study, we proposed a new method to extend single-slab MRF to multiband multi-slab acquisition. The slab boundary artifacts due to imperfect slab profile in multi-slab acquisition is overcome by a overlapping-slab acquisition strategy and MRF reconstruction from the multiband multi-slab data can be obtained using our previously proposed temporal sharing reconstruction method.}
}
@inproceedings{ISMRM2018_4264,
annote={ISMRM2018_4264},
pages={4264},
file={ISMRM2018_4264.pdf:ISMRM2018_4264.pdf:PDF},
title={Influence of Off-resonance on {FISP} Magnetic Resonance Fingerprinting ({FISP}-{MRF})},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4264.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Bartosz Guzek and Gregor Körzdörfer and Mathias Nittka and Josef Pfeuffer},
abstract={FISP-MRF is a robust method to acquire T1 and T2 maps. The unbalanced gradient in slice-selection direction should reduce the sensitivity of FISP-MRF on off-resonances. This work investigated the dependency of T1 and T2 values on field inhomogeneities in simulations and measurements on phantoms and in vivo by applying different spatial magnetic field offsets. Depending on the sequence implementation, the measured T1 and T2 values were altered in different ways by the off-resonances. Outcomes showed that the actual implementation of the dephasing moment strongly affects the results. Using a constant instead of variable TR further reduced the sensitivity to off-resonances.}
}
@inproceedings{ISMRM2018_4265,
annote={ISMRM2018_4265},
pages={4265},
file={ISMRM2018_4265.pdf:ISMRM2018_4265.pdf:PDF},
title={Balanced multi-shot {EPI} for accelerated Cartesian {MR} Fingerprinting: An alternative to spiral {MR} Fingerprinting},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4265.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Arnold Julian Vinoj Benjamin and Pedro A. Gómez and Mohammad Golbabaee and Zaid Mahbub and Tim Sprenger and Marion I. Menzel and Michael Davies and Ian Marshall},
abstract={This study shows the practical implementation of an accelerated Cartesian Magnetic Resonance Fingerprinting (MRF) scheme using a multi-shot Echo Planar Imaging (EPI) readout. Its performance is compared with conventional spiral MRF and the fast convergence of accelerated iterative reconstructions for this method is shown.}
}
@inproceedings{ISMRM2018_4266,
annote={ISMRM2018_4266},
pages={4266},
file={ISMRM2018_4266.pdf:ISMRM2018_4266.pdf:PDF},
title={Acceleration of the Cartesian acquisition of {MR} fingerprinting using the keyhole acquisition and view-sharing reconstruction},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4266.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ryoichi Sasaki and Yasuhiko Terada},
abstract={MR fingerprinting (MRF) is a promising approach that enables quantification of multiple tissue parameters at a single scan. MRF uses spiral sampling which requires a high fidelity of gradient hardware. Meanwhile, MRF with the Cartesian sampling is feasible for conventional scanners with the moderate hardware fidelity, but it comes at the cost of the elongation of the acquisition time. Here we propose an acceleration method for the Cartesian MRF acquisition that enables the 8-fold acceleration. The quantitative errors and undersampling artifacts in the T
1 and T
2 maps are alleviated by using the keyhole acquisition and view-sharing reconstruction.}
}
@inproceedings{ISMRM2018_4267,
annote={ISMRM2018_4267},
pages={4267},
file={ISMRM2018_4267.pdf:ISMRM2018_4267.pdf:PDF},
title={Bloch-Torrey Simulation to Quantify Diffusion Effects on Multi-Parametric Sequences with Application for {MR} Fingerprinting},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4267.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Inbar Seroussi and Nir Sochen and Noam Ben-Eliezer and Ofer Pasternak},
abstract={Quantifying the effect of self-diffusion on multi-parametric sequences, such as those used for Magnetic Resonance Fingerprinting (MRF) is important to increase the accuracy of dictionary based parameter estimation. To quantify diffusion, we propose a signal simulation approach, which replaces the Bloch equation with the Bloch-Torrey equation and accounts for protocol and scan dependent parameters. We apply this framework on a Multi Spin Echo (MSE) protocol and quantify the diffusion encoding introduced by the spoiler gradients in this sequence. We further show that increasing the spoiler strength would allow detecting diffusion by including the diffusion effect in the dictionary.}
}
@inproceedings{ISMRM2018_4268,
annote={ISMRM2018_4268},
pages={4268},
file={ISMRM2018_4268.pdf:ISMRM2018_4268.pdf:PDF},
title={High-dimensional and accurate dictionary fitting with B-spline interpolation and gradient-based optimization},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4268.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Willem van Valenberg and Stefan Klein and Frans M. Vos and Lucas J. van Vliet and Dirk H.J. Poot},
abstract={Dictionary matching in MR fingerprinting acquisitions quantifying many parameters, such as
T
1 T
2, T
2’, B
0, B
1+ and PD, becomes prohibitively expensive due to the dense grid in each dimension of the dictionary that is required. In this work we propose B-spline interpolation of the dictionary to reduce the dictionary size and to enable efficient nonlinear least-squares fitting by gradient-based optimization methods. The experiments show that the method substantially reduces fitting error, especially when the SNR is high and dictionary resolution is the limiting factor for improving the precision of the quantitative parameters.}
}
@inproceedings{ISMRM2018_4269,
annote={ISMRM2018_4269},
pages={4269},
file={ISMRM2018_4269.pdf:ISMRM2018_4269.pdf:PDF},
title={Accelerated Magnetic Resonance Fingerprinting Using Convolutional Neural Network},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4269.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ying Liao and Qiang Zhang and Di Cui and Edward Sai-Kam Hui and Huijun Chen},
abstract={The purpose of this work is to accelerate the acquisition of Magnetic Resonance Fingerprinting (MRF) using Convolutional Neural Network (CNN). Compared with traditional MRF reconstruction using 1000 time points, our CNN model shows better reconstruction fidelity in T
2 and similar reconstruction fidelity in T
1 using 300 time points. Our study suggests that CNN-based method may be an effective tool in the acceleration of MRF reconstruction.}
}
@inproceedings{ISMRM2018_4270,
annote={ISMRM2018_4270},
pages={4270},
file={ISMRM2018_4270.pdf:ISMRM2018_4270.pdf:PDF},
title={Simultaneous Diffusion, {PD}, T1 and T2 Mapping with Optimized {MR} Fingerprinting {EPI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4270.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ouri Cohen and Matthew S. Rosen},
abstract={MR Fingerprinting (MRF) is a recent technique for simultaneous acquisition of multi-parametric tissue maps. Beyond the proton density (PD), T1 and T2 maps routinely obtained with conventional MRF sequences, quantitative diffusion maps are of great clinical interest but are challenging to acquire due to long scan times and poor resolution. In previous work we’ve demonstrated an optimized MRF EPI sequence that allows short scan times. Here we characterize its diffusion sensitivity and demonstrate its potential for simultaneous mapping of PD, T1, T2 and diffusion.
}
}
@inproceedings{ISMRM2018_4271,
annote={ISMRM2018_4271},
pages={4271},
file={ISMRM2018_4271.pdf:ISMRM2018_4271.pdf:PDF},
title={Multi-row and Loopole-type Self-decoupled {RF} Coils},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4271.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Xinqiang Yan and John C. Gore and William A. Grissom},
abstract={Self-decoupled coils that do not require additional decoupling treatments provide increased freedom for RF array design. However, only a single-row array was demonstrated in the initial work and it is not clear whether this design can be applied to multi-row arrays. Furthermore, the initial self-decoupled coil was fed in a horizontal conductor and thus its B
1 field was same as that of a conventional loop. If fed at a corner or in a vertical conductor, the self-decoupled coil may exhibit asymmetric currents and act as a “loopole” which can be used to improve transmit or receive performance. In this work, we proposed several solutions for multi-row arrays and also investigate loopole-type self-decoupled coils. We found that the self-decoupled coil design can be applied to multi-row arrays with a simple modification (fed at corner) or adding another decoupling method (such as overlapping). The self-decoupled method could also be used to improve transmit efficiency and SNR by optimizing the feed port’s positions.}
}
@inproceedings{ISMRM2018_4272,
annote={ISMRM2018_4272},
pages={4272},
file={ISMRM2018_4272.pdf:ISMRM2018_4272.pdf:PDF},
title={A Split 8-channel 7T Knee Coil},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4272.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Xinqiang Yan and John C. Gore and William A. Grissom},
abstract={Split coil designs are attractive to provide easy access and tight-fitting for patients. A common split coil uses plug connectors to join the two halves together. But this requires additional mechanical design to ensure a robust and reliable connection. In this work, we propose a novel split array coil for 7T knee imaging where the two halves are electrically isolated from each other and do not need any geometrical constraints such as overlapping. The array comprises mixed self-decoupled loop coils and conventional loop coils, which can be split between the self-decoupled coils because they are intrinsically decoupled. This design also allows their distance to be slightly adjusted for different subjects and adapt to more of the population, while fitting tightly around the anatomy for higher sensitivity.}
}
@inproceedings{ISMRM2018_4273,
annote={ISMRM2018_4273},
pages={4273},
file={ISMRM2018_4273.pdf:ISMRM2018_4273.pdf:PDF},
title={Application of Asymmetric Mode Ladder Resonators for Improved Efficiency of Individual Elements in Transceive Arrays},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4273.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Adam Maunder and Fraser Robb and Madhwesha Rao and Jim Wild},
abstract={Conventional vest coil designs typically have less homogeneous excitation and higher SAR than volume resonators. Here we introduce a hybrid of a ladder resonator and transceiver array to provide the individual benefits of both. A network theory approach is presented for the calculation of tuning values. Simulation and measurement of a two ladder element transmit array with three loop sections each is demonstrated. Additionally, the six individual loop sections are employed as separate receive coil elements. Improved transmit homogeneity and lower specific absorption ratio is observed in simulation against a comparable transmit vest coil array. The tuning and transmit field homogeneity is verified through measurement of imaging performance.}
}
@inproceedings{ISMRM2018_4274,
annote={ISMRM2018_4274},
pages={4274},
file={ISMRM2018_4274.pdf:ISMRM2018_4274.pdf:PDF},
title={8-channel whole-brain center-fed dipoles with quadrature frontal loops coil array},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4274.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jérémie Clément and Sandra Da Costa and Rolf Gruetter and Özlem Ipek},
abstract={To achieve highly efficient whole-brain coverage, including cerebral cortex and cerebellum, a single-row 8-channel RF coil array, built with center-fed dipoles, was investigated. B
1+ maps and anatomical images were acquired on the human brain for RF phases optimized over the whole-brain and high transmit field performances were shown in both cerebral cortex and cerebellum with good homogeneity. Functional MRI data was acquired on auditory cortices and demonstrated higher robustness compared to a commercial volume coil.}
}
@inproceedings{ISMRM2018_4275,
annote={ISMRM2018_4275},
pages={4275},
file={ISMRM2018_4275.pdf:ISMRM2018_4275.pdf:PDF},
title={Experimental and numerical evaluations of simultaneously excitable Eigenmodes in a 20-channel transmit {RF} array for 7 Tesla human {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4275.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Tales Santini and Yujuan Zhao and Sossena Wood and Junghwan Kim and Nadim Farhat and Narayanan Krishnamurthy and Tiejun Zhao and Tamer S. Ibrahim},
abstract={The Eigenmodes of a 20-channel Tic-Tac-Toe RF array are presented and analyzed. The Eigenmodes were calculated for each excitation level in Z (static magnetic field) direction, resulting in 4 modes per level and 20 in total. FDTD simulations and in-vivo experiments were performed. Quadrature mode is the most efficient and generally excites the center of the brain; Anti-quadrature mode excites the head periphery; andthe Zero-phase mode excites the cerebellum. Up to 5 modes can be excited simultaneously which can potentially result in a homogenous B1+ pattern and low levels of Average/peak SAR.}
}
@inproceedings{ISMRM2018_4276,
annote={ISMRM2018_4276},
pages={4276},
file={ISMRM2018_4276.pdf:ISMRM2018_4276.pdf:PDF},
title={{SNR} Improvement of In Vivo 31P {MRSI} in Human Brain using Head-Shape Ultrahigh Dielectric Constant Material at 7T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4276.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Byeong-Yeul Lee and Xiao-Hong Zhu and Sebastian Rupprecht and Maryam Sarkarat and Michael T. Lanagan and Qing X. Yang and Wei Chen},
abstract={Increased RF power (thus, higher SAR) and inadequate detection sensitivity (or SNR) even at high/ultrahigh field are the major challenges for X-nuclei MRS imaging (MRSI) for human applications. In this work, we demonstrate that using the ultrahigh dielectric constant material (uHDM) conformed to the human head incorporated into the RF head volume coil, improved detection sensitivity and reduced demand of RF transmit power were achieved across an entire object for testing phantom and human brain
31P MRSI at 7T. Therefore, incorporating optimized geometry of uHDM with RF coil can significantly boost SNR and reduce SAR in X-nuclei MRS applications, ultimately, improve spatiotemporal resolution.}
}
@inproceedings{ISMRM2018_4277,
annote={ISMRM2018_4277},
pages={4277},
file={ISMRM2018_4277.pdf:ISMRM2018_4277.pdf:PDF},
title={High-accuracy {SNR} calculation for multi-channel receiver coils with electromagnetic simulation considering coil-component losses},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4277.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Kohjiro Iwasawa and Yosuke Otake and Hisaaki Ochi and Hideta Habara and Masayoshi Dohata and Yoshihisa Soutome},
abstract={Electromagnetic simulation is a powerful tool to evaluate optimal radio frequency (RF) coil design without costly prototypes. However, RF receiver coils have accessory circuits, such as decoupler circuits, that make it difficult to reflect accurate coil loss. This leads to calculation error which can be non-negligible even in high static magnetic fields, especially for small loop coils. We measured the coil-component losses and took them into account for the simulation to calculate the signal-to-noise ratio (SNR). The calculated SNR had less than 5\% error when compared to SNR measured with a 1.5-T MRI scanner for 10-channel receiver-array coils, confirming high accuracy of multi-channel SNR simulation.}
}
@inproceedings{ISMRM2018_4278,
annote={ISMRM2018_4278},
pages={4278},
file={ISMRM2018_4278.pdf:ISMRM2018_4278.pdf:PDF},
title={A 16-channel Dense Array for Macaque Cortices Imaging at 7T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4278.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Xiaotong Zhang and Yang Gao and Meizhen Qian and Yi Sun and Anna Wang Roe},
abstract={To improve the SNR and time efficiency of monkey brain imaging, we designed a multi-channel dense receive array for use at 7T. It can be flexibly mounted over the monkey’s head and can be used for studies in both awake and anesthetized conditions. The aim of the current design focuses on visualizing sub-millimeter tissue structure and probing neuronal activities in cortices of macaques and as demonstrated in the experiment results, good SNR and tSNR are attained in cortical layers and up to ~1cm depth beneath the skull. The area of B1 sensitivity is large enough to encompass any area of the visual cortex.}
}
@inproceedings{ISMRM2018_4279,
annote={ISMRM2018_4279},
pages={4279},
file={ISMRM2018_4279.pdf:ISMRM2018_4279.pdf:PDF},
title={Evaluation of Egyptian axe dipole antenna as an array element for head imaging at 7T {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4279.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Irena Zivkovic and Thomas O'Reilly and Wyger Brink and Andrew Webb},
abstract={In this abstract we propose a new antenna design as a transmit array element for proton head imaging at 7T that combines a small feeding dipole that is capacitively coupled, as a so-called ‘indirect’ or ‘passive’ feed, to an ‘Egyptian’ axe dipole. B
1+ and SAR efficiency of the proposed antenna have been compared numerically with a conventional dipole antenna of the same length. A head array consisting of eight antenna elements has been constructed and tested. This array element offers a large reduction in SAR compared to equally sized linear dipoles while maintaining their B
1+ profile as well as reducing the impact of antenna loading on the resonance frequency.}
}
@inproceedings{ISMRM2018_4280,
annote={ISMRM2018_4280},
pages={4280},
file={ISMRM2018_4280.pdf:ISMRM2018_4280.pdf:PDF},
title={Marmoset coil arrays for functional imaging of awake monkeys at 9.4T and 3T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4280.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Azma Mareyam and Jitendra Sharma and Mitul Desai and Christin Y Sander and Eric Frederick and Benjamin B Bartelle and Atsushi Takahashi and Lawrence L Wald},
abstract={High-field functional MRI of non-human primates provides elevated BOLD contrast in a well-established neuroscience model but requires an optimized coil design to boost the SNR, facilitate image acceleration while maintaining mechanical and electrical stability during the awake primate experiment. In this work we have constructed and tested 4-channel 9.4T and a 5-channel 3T receive-only array optimized for high-resolution whole-brain imaging of the anesthetized and awake marmosets.}
}
@inproceedings{ISMRM2018_4281,
annote={ISMRM2018_4281},
pages={4281},
file={ISMRM2018_4281.pdf:ISMRM2018_4281.pdf:PDF},
title={One for all: Ultra-wideband (279-500{MH}z) self-grounded bow-tie antenna for ultrahigh-field and thermal {MR}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4281.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Lukas Winter and Hana Dobšíček Trefná and Yiyi Ji and Till Huelnhagen and Thoralf Niendorf},
abstract={A compact self-grounded ultra-wideband bow-tie antenna is presented that operates in a frequency range from 279 MHz (
19F at 7.0 T) up to 500 MHz (
1H at 11.7 T). The antenna is smaller and lighter than previous designs making it an excellent candidate for high density multi-channel transmit/receive arrays. It can be driven directly at 50Ω eliminating the need for a tuning/matching circuit and associated component losses and costs. The ultra-wideband antenna was tested successfully in-vivo at 7.0 T for
19F and
1H imaging. Its design supports high average power applications such as targeted RF heating or thermal MR.}
}
@inproceedings{ISMRM2018_4282,
annote={ISMRM2018_4282},
pages={4282},
file={ISMRM2018_4282.pdf:ISMRM2018_4282.pdf:PDF},
title={Development of a dedicated laryngeal surface coil for improved high resolution imaging in laryngeal cancer},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4282.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Thomas Ruytenberg and Berit Verbist and Jordi Vonk-Van Oosten and Paul de Bruin and Eleftheria Asteinidou and Elisabeth Sjogren and Andrew Webb},
abstract={A dedicated 4-channel larynx coil at 3T has been developed, allowing for high-resolution (1 mm isotropic) imaging of the larynx. The coil is flexible and can therefore be used on a radiotherapy mask to allow in-mask scanning of the larynx for radiotherapy planning purposes. Breathing and swallowing artefacts were eliminated using respiratory triggering and artefacts arising from pulsatile flow were suppressed using a saturation pulse. The improved image quality and resolution helps in assessing whether transoral surgical approaches on laryngeal tumors are possible.}
}
@inproceedings{ISMRM2018_4283,
annote={ISMRM2018_4283},
pages={4283},
file={ISMRM2018_4283.pdf:ISMRM2018_4283.pdf:PDF},
title={Improved transmit efficiency with Slotted Microstrip Transmission Line {RF} Coil Element for Ultra-high magnetic field {MR} Imaging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4283.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Vijayaraghavan Panda and Siva Sai Krishna Puranam and Lance Delabarre and Gregor Adriany and Anand Gopinath},
abstract={Slots are introduced to the standard microstrip transmission line RF coil element, to enhance the current density and obtain better improved transmit efficiency. A prototype of such a slotted microstrip element is compared with the standard microstrip element at 297.25 MHz for 7T MR scanner to show the feasibility of the design at higher magnetic fields. A 60\% improvement in the transmit efficiency and increased penetration of field into the phantom are observed experimentally. The B
1+ field distribution in both transverse and sagittal plane are shown for the comparison.}
}
@inproceedings{ISMRM2018_4284,
annote={ISMRM2018_4284},
pages={4284},
file={ISMRM2018_4284.pdf:ISMRM2018_4284.pdf:PDF},
title={Perfectly Conformal Coils: A Novel Method for Patterning Coils on Complex 3D Surfaces},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4284.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Karthik Gopalan and Ana C. Arias and Michael Lustig},
abstract={We describe a novel technique for fabricating coils on complex three dimensional surfaces. Conductors are printed on a planar sheet then vacuum formed to create arrays that perfectly conform to the body. We envision a process where a custom coil can be built to completion at the push of a button. Through a combination of 3D scanning, RF modeling and mechanical simulation, coils could be rapidly manufactured for any body part. Here, we demonstrate the first steps toward our goal by building a 3 channel posterior head coil and scanning in vivo at 3T.}
}
@inproceedings{ISMRM2018_4285,
annote={ISMRM2018_4285},
pages={4285},
file={ISMRM2018_4285.pdf:ISMRM2018_4285.pdf:PDF},
title={A 3He/1H Switched Frequency High-Pass Birdcage Coil for Hyperpolarized 3He Imaging in Neonates at 1.5 T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4285.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ronald G Pratt and Randy O Giaquinto and Christopher M Ireland and Barret Daniels and Wolfgang Loew and Nara S Higano and Robert Thomen and Jason C Woods and Charles L Dumoulin},
abstract={We report details on the fabrication and performance of a transmit/receive
3He/
1H switched frequency 16 rung high-pass birdcage coil for neonatal imaging at 1.5 Tesla. The coil enables collection of
3He images of neonatal lungs inflated with hyperpolarized
3He gas and ultra-short echo time (UTE)
1H images. Rotation of a shaft in the coil housing shifts the coil between
3He and
1H operating modes.
3He and UTE
1H images of explanted lungs inflated with hyperpolarized
3He gas collected using the coil demonstrate the excellent image quality achieved with the coil.}
}
@inproceedings{ISMRM2018_4286,
annote={ISMRM2018_4286},
pages={4286},
file={ISMRM2018_4286.pdf:ISMRM2018_4286.pdf:PDF},
title={Comparison of single-loop endoluminal receiver coils based on serial or parallel active decoupling circuits using controllable {MEMS} switches},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4286.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={HAMZA RAKI and ISABELLE SANIOUR and FRASER ROBB and KEVIN TSE VE KOON and HENRI SOUCHAY and SIMON A. LAMBERT and OLIVIER BEUF},
abstract={Two prototypes of single-loop endoluminal receiver coils integrating serial and parallel active decoupling circuits using controllable MEMS switches were built and compared to a reference coil with PIN-diode circuit. Parallel MEMS coil had a significantly higher quality factor compared to the serial MEMS coil and the reference coil. The switching delays of both MEMS coils were about few microseconds (< 8µs). The characterization on 3.0T MRI system showed comparable signal intensity distribution for the different coil configurations.}
}
@inproceedings{ISMRM2018_4287,
annote={ISMRM2018_4287},
pages={4287},
file={ISMRM2018_4287.pdf:ISMRM2018_4287.pdf:PDF},
title={Wavelength independent λ/40 Composite Right/Left-Handed Transmission Line Coil},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4287.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Dongyean Koh and Jörg Felder and Chang-Hoon Choi and N. Jon Shah},
abstract={A Dual Series (DS) Composite Right/Left Handed (CRLH) Microstrip Transmission Line (MTL) coil for MRI was designed and verified in a commercial 3T Scanner. According to metamaterial theory, we demonstrate the existence of the right-handed leaky mode to be in the UHF region. For design proposes we propose an equivalent circuit parameter extraction method and demonstrate that the phase velocity of the DS-CRLH MTL coil’s guided mode is located in a fast wave region.}
}
@inproceedings{ISMRM2018_4288,
annote={ISMRM2018_4288},
pages={4288},
file={ISMRM2018_4288.pdf:ISMRM2018_4288.pdf:PDF},
title={A receive-only, double-tune coil using preamplifier decoupling},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4288.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={YongHyun Ha and Chang-Hoon Choi and Jörg Felder and N. Jon Shah},
abstract={In this work we describe two methods for the double-tuned receive only coil design using preamplifier decoupling. Both the LC trap and the lattice balun can be integrated into the receive line to isolate signals resonant at two different frequencies. It was found that the method using LC traps was more effective when the coils were tuned at a higher frequency (normally proton), while the lattice balun method provided higher blocking impedance for the X-nuclei coil.}
}
@inproceedings{ISMRM2018_4289,
annote={ISMRM2018_4289},
pages={4289},
file={ISMRM2018_4289.pdf:ISMRM2018_4289.pdf:PDF},
title={Anatomically adaptive coils for {MR} Imaging – A 6-channel Demonstrator Array study at 1.5 Tesla},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4289.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Bernhard Gruber and Stephan Zink},
abstract={Many of today’s MR coils are still somehow rigid and inflexible in their size. Even highly flexible arrays basically maintain only one specific body-part in a defined range. Anatomically adaptive coils potentially provide the necessary freedom to have a one-size-fits-all design for MRI in clinic. This would lower costs, improve the signal-to-noise ratio (SNR) and increase the patient comfort. To evaluate the potential SNR improvement of adaptive arrays, maintaining an optimal filling factor, a 6-channel Demonstrator array setup, comprised of stretchable loop elements at 1.5T with equal electrical properties as standard elements, was used.}
}
@inproceedings{ISMRM2018_4290,
annote={ISMRM2018_4290},
pages={4290},
file={ISMRM2018_4290.pdf:ISMRM2018_4290.pdf:PDF},
title={A 256-channel Cardiac Coil for accelerated Cardiac Imaging at 3 Tesla - Evaluation of a 32-channel Prototype},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4290.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Bernhard Gruber and Arjan D. Hendriks and Cezar Alborahal and Gustav J. Strijkers and Dennis W.J. Klomp and Tim Leiner and Martijn Froeling},
abstract={There is an urgent need for highly accelerated cardiac imaging to facilitate shorter examination times and increased patient comfort. The purpose of this study was to investigate if a large number of small surface coils can increase the maximal obtainable acceleration factor, by maximizing SNR and minimizing the g-factor. We demonstrate the potential of a high-density cardiac receive array for faster cardiac imaging compared to current available MR coils. Measurements with a 32-channel cardiac prototype at 3T show a 4-fold increase in acquisition speed at similar SNR. At the cost of a small SNR-drop, 30-fold acceleration factors are possible.}
}
@inproceedings{ISMRM2018_4291,
annote={ISMRM2018_4291},
pages={4291},
file={ISMRM2018_4291.pdf:ISMRM2018_4291.pdf:PDF},
title={Ophthalmic magnetic resonance imaging using a 7-channel receive-only phased array coil: Quantitative image evaluation of anatomical orbital structures at 3.0 T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4291.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Kyu-Ho Song and Young Han Lee and Min Jung Kim and Jin-Suck Suh and Bo-Young Choe},
abstract={The surface coil which yields a higher signal-to-noise ratio only in small area can improve with multi-channel that each channel SNR is combined with a sum-of-squares method. This processing achieves an overall higher SNR in the region of interest (or field of view). In the present study, a 7-channel orbit array coil was developed for ophthalmic imaging. Image quality evaluation by using the designed orbit array coil was examined for imaging the eye, optical nerve and ocular muscles with orbit.}
}
@inproceedings{ISMRM2018_4292,
annote={ISMRM2018_4292},
pages={4292},
file={ISMRM2018_4292.pdf:ISMRM2018_4292.pdf:PDF},
title={Establishing {MR} angiography of the mouse eye},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4292.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Gangchea Lee and Kenneth Kim and Thomas Neuberger},
abstract={High field Magnetic Resonance Angiography on mouse eye can be used to investigate the vasculature near the mouse eye. One of the difficulties with using on mice is the induced moving artifact. To overcome this obstacle, a custom mouse restrainer containing both a tooth bar and ear bars was designed and constructed for mouse eye imaging. The restrainer, in combination with a rigid surface coil, enabled three-dimensional mouse eye images to be captured with 30 um isotropic resolution. A three-dimensional mouse angiography was created by segmenting ocular blood vessels from these images.}
}
@inproceedings{ISMRM2018_4293,
annote={ISMRM2018_4293},
pages={4293},
file={ISMRM2018_4293.pdf:ISMRM2018_4293.pdf:PDF},
title={A Slot Antenna Array for Body Imaging at 7T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4293.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Leeor Alon and Karthik Lakshmanan and Jan Paska and Riccardo Lattanzi and Chris M. Collins},
abstract={Slot antennas have been shown to be promising for body imaging at Ultra High Field (7T). In this work, a 6-channel transmit-receive slot array was constructed, quantitative evaluation of the performance was conducted and practical design features are discussed.}
}
@inproceedings{ISMRM2018_4294,
annote={ISMRM2018_4294},
pages={4294},
file={ISMRM2018_4294.pdf:ISMRM2018_4294.pdf:PDF},
title={{RF} Shimming and Improved {SAR} Safety for 16-Channel Transmit/Receive {RF} Coil Arrays for Cardiac {MRI} at 7T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4294.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ibrahim A. Elabyad and M. R. Stefanescu and M. Terekhov and Frank Resmer and Titus Lanz and L. M. Schreiber},
abstract={In this work, comprehensive high resolution EM-simulations were performed for three different 16-element transmit/receive (Tx/Rx) planar RF coil arrays loaded with the anatomical Duke human model to examine their performance in cardiac magnetic resonance imaging (cMRI) at 7T. An optimization routine has been developed in MATLAB to optimize the phases for B1+ field homogeneity with minimal local SAR values within the Duke human biological model. Before B1-shimming, all arrays demonstrated approximately the same B1+ field distributions with a pronounced higher field values near to the coil surface. With phase increments of 45° phase shift between each of the 8-element pairs, the arrays generate pronounced local SAR hot spots with maximum values of 10.3, 10.1 and 9.4 W/kg for design 1, 2 and 3, respectively. In accordance with IEC regulations, the calculated 10 g averaged SAR values were found to be within the limits and the relative hot spots were found to be below 11 W/kg. RF shimming improves the B1+ field homogeneity by 24\%, 49\% and 40\% in the central sagittal slice for design 1, 2 and 3, respectively.
}
}
@inproceedings{ISMRM2018_4295,
annote={ISMRM2018_4295},
pages={4295},
file={ISMRM2018_4295.pdf:ISMRM2018_4295.pdf:PDF},
title={Compact and adjustable metasurface-based resonator for in-vivo {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4295.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ekaterina A. Brui and Alena V. Shchelokova and Mikhail A. Zubkov and Irina V. Melchakova and Stanislav B. Glybovski and Anna E. Andreychenko and Alexey P. Slobozhanyuk},
abstract={We have numerically and experimentally approved that a compact metasurface-based resonator with miniaturized capacitive load may efficiently operate as a wireless surface coil in 1.5 T MR scanner. Our results show that for a properly adjusted metasurface eigenmode resonance frequency it is possible to substantially increase the signal-to-noise ratio that was confirmed both with the phantom and in vivo experiments.}
}
@inproceedings{ISMRM2018_4296,
annote={ISMRM2018_4296},
pages={4296},
file={ISMRM2018_4296.pdf:ISMRM2018_4296.pdf:PDF},
title={Dual-nuclei metamaterial implementation for sodium and proton acquisition at 3 T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4296.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Rita Schmidt and Andrew Webb},
abstract={Several studies have shown proof-of-principle implementations of metamaterials for local RF transmit efficiency and sensitivity improvement. The most common implementations are based on set of split-rings or set of wires. To support a dual-band enhancement, the design here relies on a combination of the mentioned above two types of metamaterials. Whereas in the original study we focused on 7T
31P/
1H dual-band implementation, in this work we were interested to examine the possibility to extend it to much lower frequencies, namely a dual-band metamaterial for 3T
23Na/
1H local signal enhancement. The implementation was examined in EM simulations and in phantom experiments at 3 T.}
}
@inproceedings{ISMRM2018_4297,
annote={ISMRM2018_4297},
pages={4297},
file={ISMRM2018_4297.pdf:ISMRM2018_4297.pdf:PDF},
title={Metamaterial {RF} Shield with Reduced Specific Absorption Rate and Improved Transmit Efficiency for 9.4 T {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4297.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Haiwei Chen and Lei Guo and Mingyan Li and Chunyi Liu and Shanshan Shan and Yaohui Wang and Ewald Weber and Feng Liu and Stuart Crozier},
abstract={A novel RF shield using metamaterial absorber was designed for 9.4 T MRI. This new design focuses on improving the transmit efficiency of RF coils and reducing the Specific Absorption Rate (SAR) in the subject. A new layered unit cell structure of metamaterial absorber was used for constructing the RF shield. Full-wave simulation results were presented and compared with a conventional copper RF shield; the results suggest that the proposed structure could achieve improved imaging performance.}
}
@inproceedings{ISMRM2018_4298,
annote={ISMRM2018_4298},
pages={4298},
file={ISMRM2018_4298.pdf:ISMRM2018_4298.pdf:PDF},
title={Metamaterial Bore Liners as High-Field Body Transmit Coils: Advantages Over Standard Birdcage Coils},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4298.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Navid Hosseini and Justin G. Pollock and Ashwin K. Iyer and Nicola De Zanche},
abstract={Simulations are presented of a negative-permittivity metamaterial bore liner designed to perform volume excitation at 200 MHz. The liner offers performance comparable to that of birdcage coils in terms of both field homogeneity, sensitivity and SAR, while allowing operation at frequencies beyond those where birdcage coils operate reliably.}
}
@inproceedings{ISMRM2018_4299,
annote={ISMRM2018_4299},
pages={4299},
file={ISMRM2018_4299.pdf:ISMRM2018_4299.pdf:PDF},
title={Evaluation of Different Coupling Schemes for a Dielectric Resonator in Magnetic Resonance Imaging at 600 {MH}z- a Simulation Approach},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4299.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Gangchea Lee and Wei Luo and Michael Lanangan and Thomas Neuberger},
abstract={The TE01δ mode of the ring Dielectric Resonator (DR) is of interest to the high field MRI community for it generates highly homogenous fields over large volumes inside the DR. The ring DRs behave differently depending on the method of coupling. Six different coupling methods using the conducting wire were simulated three dimensionally. Differences in the electromagnetic field inside the DR, depending on the coupling method, were observed in the simulation. These results were interpreted to determine the mechanism producing the highest magnetic field using triple loop coupling.}
}
@inproceedings{ISMRM2018_4300,
annote={ISMRM2018_4300},
pages={4300},
file={ISMRM2018_4300.pdf:ISMRM2018_4300.pdf:PDF},
title={Double Facing Miniaturized Patch Antennas with High Permittivity Plugs},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4300.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Gangchea Lee and Navid Gandji and Seokwon Jung and Elena Semouchkina and Michael Lanangan and Thomas Neuberger},
abstract={Substituting the conventional Radio Frequency coil (RF coil) with a patch antenna has the potential to increase the magnetic field homogeneity in large Fields Of View (FOV). The homogeneity can be improved even more when two of these antennas are facing each other. The size of the patch antennas needed to be reduced to fit inside the scanner bore to use them as RF coils. This was done via inserting high dielectric material plugs. The two facing patch antennas system was also fabricated and tested.}
}
@inproceedings{ISMRM2018_4301,
annote={ISMRM2018_4301},
pages={4301},
file={ISMRM2018_4301.pdf:ISMRM2018_4301.pdf:PDF},
title={Possibilities for local {SAR} Reduction with u{HDC} Material \& 2 Ch p{TX}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4301.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Christopher Sica and Sebastian Rupprecht and Ryan Hou and Qing Yang},
abstract={Variation of the RF transmit field polarization in conjunction with the application of a uHDC monolithic block was explored within the context of reducing local SAR, through RF field simulations and B
1+ mapping. A linear polarization in conjunction with a discrete uHDC block was found to substantially reshape the null band in the electric field, which opens new possibilities for local SAR reduction.}
}
@inproceedings{ISMRM2018_4302,
annote={ISMRM2018_4302},
pages={4302},
file={ISMRM2018_4302.pdf:ISMRM2018_4302.pdf:PDF},
title={Evaluation of High-dielectric Pads for Macaque Brain Imaging at 7T: A Pilot Study},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4302.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jie Zhao and Wei Luo and Meizhen Qian and Yi Sun and Ling Xia and Xiaotong Zhang},
abstract={Non-human-primates are a valuable model for investigating the structure and function of the brain. The high-dielectric pads have been shown to increase B
1 sensitivity and enhance image SNR and contrast locally in the human brain at high and ultra-high field. In this study, our pilot experiment results suggest that high-dielectric pads can effectively enhance macaque whole brain imaging at 7T and in the meantime, do not increase the receive array element coupling, nor have any deterioration over the B
0 homogeneity within the monkey brain.}
}
@inproceedings{ISMRM2018_4303,
annote={ISMRM2018_4303},
pages={4303},
file={ISMRM2018_4303.pdf:ISMRM2018_4303.pdf:PDF},
title={Low-loss high-permittivity blocks improves the signal-to-noise ratio of surface coils at 3 Tesla},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4303.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Thomas O'Reilly and Wyger Brink and Andrew Webb},
abstract={The performance of surface coils for proton imaging at 3 Tesla can be improved by placing low-loss high-permittivity blocks at the centre of the surface coil. The signal-to-noise ratio in a human calf of a coil with integrated dielectric block is 25\% higher close to the coil and performs comparably well compared to a standard surface coil at depths exceeding 6 cm providing a simple and effective way of improving surface coil performance.}
}
@inproceedings{ISMRM2018_4304,
annote={ISMRM2018_4304},
pages={4304},
file={ISMRM2018_4304.pdf:ISMRM2018_4304.pdf:PDF},
title={An electrically conductive {SLA} resin used for the Design of Anthropomorphic Phantoms},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4304.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Sossena Wood and Tiago Martins and Tales Santini and Tamer S Ibrahim},
abstract={In this work, we have researched the possibility of using a conductive plastic that is suitable for the design of an anthropomorphic phantom for MR testing purposes. DSM Somos® provides a clear hydrophobic SLA resin that has constitutive parameters similar to the averaged electromagnetic properties of the fat, bone and skin. The work of Wood et al.
1 highlighted these findings using numerical B1 analysis. To further examine the electrically conductive plastic SLA resin material, we performed temperature testing on areas of the plastic material where we estimated temperature rise using a TEM resonator at 7T.}
}
@inproceedings{ISMRM2018_4305,
annote={ISMRM2018_4305},
pages={4305},
file={ISMRM2018_4305.pdf:ISMRM2018_4305.pdf:PDF},
title={A Hilber Curve Based Metasurface for B1+-field Enhancement},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4305.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Elizaveta Motovilova and Shao Ying Huang},
abstract={A novel metasurface field enhancer based on Hilbert curve is presented. Its resonance behavior was studied and the B1-field enhancement with field symmetry is successfully demonstrated at 7T. On a simple loop coil model, it is shown that higher orders of Hilbert curve can form metasurfaces that increase the coil sensitivity effectively.}
}
@inproceedings{ISMRM2018_4306,
annote={ISMRM2018_4306},
pages={4306},
file={ISMRM2018_4306.pdf:ISMRM2018_4306.pdf:PDF},
title={Improved Efficacy of Cerebellar f{MRI} at 7T with Dielectric Pads Extending the Imaging Region of a Commercial Head Coil},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4306.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Manushka V. Vaidya and Mariana Lazar and Cem M. Deniz and Gillian G. Haemer and Gang Chen and Mary Bruno and Daniel K. Sodickson and Riccardo Lattanzi and Christopher M. Collins},
abstract={To improve cerebellar fMRI using a commercial head coil at 7T, we arranged High Permittivity Material (HPM) pads against the inferior, posterior region of the head. We first simulated the change in Specific energy Absorption Rate (SAR) with HPM and then examined the effects on experimental Signal to Noise Ratio (SNR), flip angle maps and measured fMRI activation throughout the brain (including the cerebellum) during a finger-tapping task in eight subjects. Both SNR and fMRI BOLD contrast were improved in the cerebellum with no potential safety detriments.}
}
@inproceedings{ISMRM2018_4307,
annote={ISMRM2018_4307},
pages={4307},
file={ISMRM2018_4307.pdf:ISMRM2018_4307.pdf:PDF},
title={Dielectric pads for high-field {MRI} at 7T: a simulation study},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4307.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Shubharthi Sengupta and Alard Roebroeck},
abstract={Dielectric pads have been shown to offer a solution to B1+ inhomogeneity at ultra-high fields. We show the transmit field effects and SAR values generated when using shape-optimised high permittivity dielectric pads for visual cortex imaging. Using a single loop coil and a single dipole, electromagnetic simulations were undertaken to validate the use of these methods using 3 different body voxel models, their B1+ distributions mapped and maximum SAR values recorded and compared.}
}
@inproceedings{ISMRM2018_4308,
annote={ISMRM2018_4308},
pages={4308},
file={ISMRM2018_4308.pdf:ISMRM2018_4308.pdf:PDF},
title={Improved performance of birdcage coils using a split-ring resonator magnetic shield.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4308.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Carel C. van Leeuwen and Martijn F. J. Lunenburg and Stanislav Glybovski and Peter R. Luijten and Dennis W. J. Klomp and Cornelis A. T. van den Berg and Alexander J. E. Raaijmakers},
abstract={Birdcage body coils make use of an RF shield that degrades B1 homogeneity of the birdcage and increases SAR levels in body parts close to the rungs. A magnetic conductor RF shield would solve this issue. A metamaterial structure of elongated split-ring resonators (SRR) was designed to achieve an artificial magnetic conductor. Simulations and measurements with planar SRR arrays over a dipole are performed. Increased B1+ penetration into phantoms is observed, indicating the shield behaves as a magnetic conductor. Additionally simulations of a birdcage antenna with such shield are performed, which show an improved B1 homogeneity with comparable SAR levels.}
}
@inproceedings{ISMRM2018_4309,
annote={ISMRM2018_4309},
pages={4309},
file={ISMRM2018_4309.pdf:ISMRM2018_4309.pdf:PDF},
title={Towards high resolution f{MRI} at 3T with a flexible composite ultra-high dielectric constant (u{HDC}) material pad},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4309.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Sebastian Rupprecht and Christopher T Sica and Jianli Wang and Gary Yang and Avery Wang and Michael T Lanagan and Qing X Yang},
abstract={We developed a novel flexible pad of uHDC material and characterized the RF fields in the visual cortex at 3T in a clinical 20- and 64-channel head coil with and without this pad. This pad was then utilized in an attempted to visualize optical dominance columns via high resolution fMRI images of the visual cortex in the 20-CH head coil and compared the results of with the results of an unenhanced 64-CH head coil.}
}
@inproceedings{ISMRM2018_4310,
annote={ISMRM2018_4310},
pages={4310},
file={ISMRM2018_4310.pdf:ISMRM2018_4310.pdf:PDF},
title={Initial Evaluation Utilizing Ultra-High Dielectric Constant (u{HDC}) Materials in Breast Imaging in 3T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4310.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Avery Wang and Sebastian Rupprecht and Christopher T. Sica and Angela Choe and Susann Schetter and Julie Mack and Qing X. Yang},
abstract={We explored the feasibility of using high dielectric constant materials to potentially further enhance signal-noise-ratio (SNR) in breast MRI. Through computer modelling at 3 Tesla (T), we showed that there can be great benefits of increasing sensitivity and specificity of breast MRI. As a side effect of using high dielectric constant materials, the RF safety can be improved by the largely increased transmit efficiency.}
}
@inproceedings{ISMRM2018_4311,
annote={ISMRM2018_4311},
pages={4311},
file={ISMRM2018_4311.pdf:ISMRM2018_4311.pdf:PDF},
title={Bloch-Siegert Shift Based Method for Mapping $B_1^+$ Magnitude of Arbitrary Multi-Transmit {RF} Configurations},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4311.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Omer F. Oran and L. Martyn Klassen and Hacene Serrai and Ravi S. Menon},
abstract={Mapping B1+ magnitude fields for any arbitrary RF-configuration of interest is desirable and often required in parallel multi-transmit systems. Conventional mapping methods work by taking either the magnitude ratio or the phase difference of MRI images and thus they fail in regions of low MRI-signal which can easily occur for an arbitrary RF-configuration. We propose a new BSS based method which always uses the CP-mode for excitation while the RF-configuration of interest is used only for the off-resonance RF-pulse. Through this approach, the proposed method works even if the RF-configuration of interest has very-low magnitudes within the imaging volume.}
}
@inproceedings{ISMRM2018_4312,
annote={ISMRM2018_4312},
pages={4312},
file={ISMRM2018_4312.pdf:ISMRM2018_4312.pdf:PDF},
title={16 Channel Coupled Network Analyzer for Characterizing p{TX} Systems at 3T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4312.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Michael Twieg and Sherry Huang and Mark A Griswold},
abstract={Recent work has shown parallel RF transmit (pTX) chains with increasing channel counts and complexity. At the same time, methods of controlling and monitoring pTX chains must improve, especially when faced with nonlinearities in the RFPAs. However, characterizing multichannel nonlinear RF systems is a daunting task for standard laboratory instruments. Here we present a coupled network analyzer (CNA) containing 16 independent RF transceivers which are used simultaneously by a digital acquisition unit (DAQ). Additional DAQ channels can be used for monitoring power consumption or temperature. The system may also be interfaced with an MRI scanner to function as a pTX synthesizer.}
}
@inproceedings{ISMRM2018_4313,
annote={ISMRM2018_4313},
pages={4313},
file={ISMRM2018_4313.pdf:ISMRM2018_4313.pdf:PDF},
title={B1 vector field mapping through multi-orientation B1+ measurements},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4313.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Seung-Kyun Lee and Sukhoon Oh},
abstract={We present theory and experimental validation of reconstruction of all three components of RF vector magnetic field (B1 vector) in MRI. Using eight-orientation B1+ magnitude mapping, the magnitudes and relative phases of all Cartesian components of B1 vector can be unambiguously determined. The method is demonstrated on a phantom in a birdcage transmit coil with a standard B1+ mapping sequence at 3T. Our method can be used to validate assumptions in MR-based electrical properties tomography (MR-EPT) and specific absorption rate (SAR) modeling.}
}
@inproceedings{ISMRM2018_4314,
annote={ISMRM2018_4314},
pages={4314},
file={ISMRM2018_4314.pdf:ISMRM2018_4314.pdf:PDF},
title={Improved Transmit Field Homogeneity in Simultaneous {EEG}-f{MRI} at 7T by Increasing {EEG} Wire Resistance},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4314.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Thanh Phong Lê and Özlem Ipek and João Jorge and Rolf Gruetter},
abstract={Simultaneous EEG-fMRI offers rich multimodal information of brain activity. However, data quality is adversely affected by mutual interactions. Especially at higher magnetic fields, conductive scalp EEG components cause substantial transmit field disruption. Here, electromagnetic field simulations and MR measurements at 7T performed on a realistic design of the wiring of a 64-channel EEG cap showed that transmit field attenuation and inhomogeneity are significantly reduced when wires are split into smaller lengths by resistors, suggesting a cancellation of resonant antenna effects. This offers an effective and practical solution to avoid EEG-induced MRI data degradation, maximizing the sensitivity benefits available at 7T.}
}
@inproceedings{ISMRM2018_4315,
annote={ISMRM2018_4315},
pages={4315},
file={ISMRM2018_4315.pdf:ISMRM2018_4315.pdf:PDF},
title={Decomposition of off-resonance fields in brain {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4315.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Pei-Yan Li and Pu-Yeh Wu and Yi-Tien Li and Ying-Hua Chu and Fa-Hsuan Lin},
abstract={We measured the off-resonance distributions from 31 subjects and decomposed these maps into orthogonal modes by Singular Value Decomposition. We found that the six SVD modes can account for the off-resonance up to 80\%. Decomposed modes of off-resonance can be used for tailored shim coil design.}
}
@inproceedings{ISMRM2018_4316,
annote={ISMRM2018_4316},
pages={4316},
file={ISMRM2018_4316.pdf:ISMRM2018_4316.pdf:PDF},
title={Development of Multi-Coil B0 Technology with Computer-Aided Design Software},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4316.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Sebastian Theilenberg and Yun Shang and Sragvi Sesha Tirumala and Christoph Juchem},
abstract={The multi-coil (MC) technique proved to enable both B
0 shimming and spatial encoding for MRI. However, to eventually establish this technology for clinical use in human subjects, it has to evolve from a proof of concept level to a professional stage. Here we present the use of computer aided design (CAD) software to overcome increased engineering challenges that are associated with complex coil geometries and larger coil currents. A customized Add-in for SolidWorks was created to convert MC designs from the text-based Public MC Information Policy format to full CAD representations and vice versa, thereby providing improved field modeling and engineering capabilities.}
}
@inproceedings{ISMRM2018_4317,
annote={ISMRM2018_4317},
pages={4317},
file={ISMRM2018_4317.pdf:ISMRM2018_4317.pdf:PDF},
title={Novel crusher coils for elimination of surface {MR} signals},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4317.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Richard Bowtell and Harry Ellis},
abstract={There are multiple applications of magnetic resonance imaging and spectroscopy for which it is useful to be able to attenuate the signal that arises from surface structures. Surface signal can be attenuated by using local coils which generate a spatially varying magnetic field that decays rapidly with distance from the surface. In previous work, crushing has been accomplished by using “meander-line” coils which the current flow is predominantly along one dimension. Here we design novel crusher coils in which the current equally flows along two orthogonal directions and demonstrate via simulations and experiments at 3 T that these coils offer advantages for surface signal crushing.}
}
@inproceedings{ISMRM2018_4318,
annote={ISMRM2018_4318},
pages={4318},
file={ISMRM2018_4318.pdf:ISMRM2018_4318.pdf:PDF},
title={The Effect of Noise on B0 Shimming: Is There a "g-Factor" for Shim Coils?},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4318.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Assaf Tal},
abstract={Active B
0 shimming involves setting currents through a set of shim coils to minimize spatial heterogeneity of B
0 over a prescribed region. This is often phrased as a least-squares problem, based on an acquired field map. Noise in the field map "propagates" and appears as spatially dependent noise in the shimmed field. We show that the shim coils can be characterized by a noise propagation matrix, which is an intrinsic property of the coils and plays an analogous role to the g-factor in sensitivity encoding. This provides a useful metric for investigating the effect of noise in active shimming.
}
}
@inproceedings{ISMRM2018_4319,
annote={ISMRM2018_4319},
pages={4319},
file={ISMRM2018_4319.pdf:ISMRM2018_4319.pdf:PDF},
title={Development of single-sided portable {NMR} methods for the sensing of mammographic density},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4319.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Patricia O'Gorman and Monique C Tourell and Tonima S Ali and Honor J Hugo and Thomas Lloyd and Erik W Thompson and Konstantin I Momot},
abstract={Single-sided NMR was used to investigate the ability of spin-relaxation time constants to distinguish between regions of low and high mammographic density in human breast tissue. Measurements were performed on breast slices obtained from women undergoing breast reduction surgery or prophylactic mastectomy. T
1 values in regions of high mammographic density were found to be significantly different to those measured in regions of low mammographic density. The findings suggest that portable NMR may be suitable for quantification of mammographic density in the breast tissue, presenting a promising and low-cost means of MD assessment in vivo without the use of ionising radiation.}
}
@inproceedings{ISMRM2018_4320,
annote={ISMRM2018_4320},
pages={4320},
file={ISMRM2018_4320.pdf:ISMRM2018_4320.pdf:PDF},
title={Repeatability of 3D {MR} Fingerprinting Measurements in Normal Breast Tissue},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4320.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ananya Panda and Yong Chen and Satyam Ghodasara and Katherine Wright and Nicole Seiberlich and Mark Alan Griswold and Vikas Gulani},
abstract={3D Breast Magnetic Resonance Fingerprinting (MRF) allows simultaneous breast tissue T
1 and T
2 mapping. In this study, same session repeatability of 3D MRF technique in normal breast tissue was evaluated (test/retest 10 minutes apart) and in two consecutive visits. The within subject coefficient of variance (wCV) for two visit scans was < 6\% for T
1 and < 5\% for T
2. The wCV for test-retest scan for T
1 was <5\% and for T
2 was 6.5\%. One-week repeatability of 3D MRF was good for both T
1 and T
2 (ICC T
1: 0.81 T
2: 0.88 at second visit). These variations are smaller than observed inter-subject variability. Thus breast MRF may be useful for longitudinal patient follow-up.}
}
@inproceedings{ISMRM2018_4321,
annote={ISMRM2018_4321},
pages={4321},
file={ISMRM2018_4321.pdf:ISMRM2018_4321.pdf:PDF},
title={Repeatability of Diffusion-Weighted Imaging Model Parameters within a Benign Breast Cancer Cohort Influences Optimal Model Choice},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4321.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Neil Peter Jerome and Igor Vidic and Liv Egnell and Torill E. Sjøbakk and Agnes Østlie and Hans E. Fjøsne and Pål Erik Goa and Tone F. Bathen},
abstract={Diffusion-weighted MR imaging (DWI) is an essential tool in oncology. Diffusion models beyond monoexponential fitting attempt to capture non-Gaussian decay using additional data acquisition. Model repeatability and suitability is critical, but often neglected. We report findings from fitting multiple diffusion models in a benign breast cancer repeatability cohort and show no clear dominance of diffusion models across voxels, patients, or scans. Repeatability of ADC, IVIM and stretched exponential parameters are reported and highlight the complexity of making inferences from DWI parameters.The potential of DWI in oncology is tempered by a need for critical appraisal of the model and parameter applicability.}
}
@inproceedings{ISMRM2018_4322,
annote={ISMRM2018_4322},
pages={4322},
file={ISMRM2018_4322.pdf:ISMRM2018_4322.pdf:PDF},
title={Are the thousands of images generated by each ultrafast dynamic contrast enhancement ({DCE}) {MRI} of breast cancer effectively summarized by color intensity projection ({CIP}) images?},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4322.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Keith S Cover and Katya M Duvivier and Pim de Graaf and Rianne Wittenberg and Ruth Smit and Joost PA Kuijer and Mark MB Hofman and Ben J Slotman and Ruud M Verdaasdonk},
abstract={Ultrafast dynamic contrast enhancement (DCE) is a MRI sequence that, when used standalone, can serially screen for breast cancer in 2 minutes. However, each acquisition generates thousands of 2D images in a 4D stack. Color intensity projections (CIP) images are 2 parameter color images that encode the time of arrival (ToA) of contrast agent in the hue (red, orange, yellow, green, cyan, blue) and the amount of contrast enhancement in the brightness. A CIP image of each ultrafast slice provides an informative summary to radiologists with the same sensitivity and specificity to malignancies as the ultrafast 4D stack.}
}
@inproceedings{ISMRM2018_4323,
annote={ISMRM2018_4323},
pages={4323},
file={ISMRM2018_4323.pdf:ISMRM2018_4323.pdf:PDF},
title={Ultrafast dynamic contrast-enhanced {MRI} of the breast: Correlations with prognostic factors of breast cancer.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4323.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ken Yamaguchi and Takahiko Nakazono and Ryoko Egashira and Hiroyuki Irie},
abstract={
- The purpose of our study is to determine the correlation between the parameters obtained from ultrafast dynamic contrast-enhanced (ultrafast DCE) MRI and prognostic factors of breast cancer.
- Fifty five breast cancers were included in this study. Ultrafast DCE sequence was performed using higher than usual parallel imaging factor and obtained with 8.3 second temporal resolution. Kinetic parameters obtained from ultrafast DCE were compared with prognostic factors.
- Mean maximum slope of invasive cancer (10.2) was significantly higher than that of DCIS (8.2).
- Ultrafast DCE MRI is useful for differentiating DCIS and invasive breast cancer.
}
}
@inproceedings{ISMRM2018_4324,
annote={ISMRM2018_4324},
pages={4324},
file={ISMRM2018_4324.pdf:ISMRM2018_4324.pdf:PDF},
title={3D {MRI} for Quantitative Analysis of Quadrant Percent Density ({QPD}): Correlation with Location of Breast Cancer Growing in Different Quadrants},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4324.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jeon-Hor Chen and Siwa Chan and Yang Zhang and Dah-Cherng Yeh and Min-Ying Su},
abstract={We applied an MR-based quadrant percent density (QPD) method to investigate the association between the occurrence of cancer and the amount of dense tissue. Computer-aided method was applied to segment the breast and dense tissue and then a breast was divided into four quadrants using nipple, centroid and chestwall as the anatomic landmarks. In a total of 206 women, 88 (42.7\%) had cancer growing in the upper-outer quadrant. Only 42 (20.4\%) women had cancer growing in the quadrant with the highest QPD, suggesting that the amount of dense tissue cannot explain the disproportional occurrence of breast cancer in different quadrants.}
}
@inproceedings{ISMRM2018_4325,
annote={ISMRM2018_4325},
pages={4325},
file={ISMRM2018_4325.pdf:ISMRM2018_4325.pdf:PDF},
title={Correlation of Breast Stiffness Measured by Ultrasound with Breast Density Measured on {MRI} Matched by Using a Prone-Supine Deformation Model},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4325.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jeon-Hor Chen and Siwa Chan and Yang Zhang and Dah-Cherng Yeh and Min-Ying Su},
abstract={We correlated breast tissue stiffness measured by US elastography with the MR-measured density from the whole breast and the tissue in the US stiffness measurement window. Twenty women were studied and only the normal breast was analyzed. A finite element model was applied to deform the prone MRI to match with supine US images by using the inversed gravity loaded transformation to locate the corresponding tissue region. There were no correlation between breast stiffness and the whole breast percent density (r=-0.09) and the local percent density (r=-0.12), suggesting that breast density and stiffness may be independent cancer risk factors.}
}
@inproceedings{ISMRM2018_4326,
annote={ISMRM2018_4326},
pages={4326},
file={ISMRM2018_4326.pdf:ISMRM2018_4326.pdf:PDF},
title={The Added Utility of Diffusion Tensor Imaging for Differentiating Malignant and Benign Breast Lesions on 3T {MRI}: A Machine Learning Based Approach},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4326.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jing Luo and Daniel S Hippe and Habib Rahbar and Sana Parsian and Savannah C Partridge},
abstract={Diffusion tensor imaging (DTI) may provide additional information on tissue characteristics over dynamic contrast enhanced (DCE) MRI, however there are conflicting results regarding its utility. Our study evaluated DCE and DTI features of histologically proven breast lesions on 3T MRI. Using a machine learning-based LASSO approach for multivariate regression and bootstrap-based internal validation, the model incorporating DCE and DTI parameters demonstrated significantly better performance in differentiating malignant and benign lesions compared to models using DCE or DTI parameters alone. These findings suggest that the addition of DTI sequences to DCE MRI may improve diagnostic performance.}
}
@inproceedings{ISMRM2018_4327,
annote={ISMRM2018_4327},
pages={4327},
file={ISMRM2018_4327.pdf:ISMRM2018_4327.pdf:PDF},
title={Diffusion-weighted Intravoxel incoherent motion ({IVIM}) {MRI} and dynamic 18F-{FDG}-{PET} imaging in breast cancer patients via simultaneous {PET}/{MR}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4327.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Andrea Liu and Artem Mikheev and Eric Kim and David S Rigie and Sylvia Adams and Deborah Axelrod and Henry Rusinek and Alto Stemmer and Kimberly Jackson and Jean Logan and Linda A Moy and Amy N Melsaether and Sungheon G Kim and Eric E Sigmund},
abstract={Aggressive breast tumors possess heterogeneity that impacts successful diagnosis and treatment. Mapping this complexity with imaging biomarkers of different biologic specificity supports patient-specific management. We compare biomarkers from diffusion-weighted MRI (intravoxel incoherent motion (IVIM)) and
18F-fluorodeoxyglucose (FDG) PET (dynamic pharmacokinetic modeling) in 10 breast cancer patients in a simultaneous PET/MR system. Voxelwise correlations were performed to study intralesion relationships between biomarkers. Intralesion correlations were observed, such as between PET plasma transfer rate K
1 and tissue diffusivity D
t, that also showed potential diagnostic value in tumor classification. This feasibility study establishes a workflow that enables more detailed investigation in larger cohorts.}
}
@inproceedings{ISMRM2018_4328,
annote={ISMRM2018_4328},
pages={4328},
file={ISMRM2018_4328.pdf:ISMRM2018_4328.pdf:PDF},
title={Attenuation Correction Map Calculation and Truncation Completion for Breast {PET}/{MR} Imaging using Deep Learning},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4328.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jacob M Johnson and Roberta M Strigel and Leah C Henze Bancroft and Amy M Fowler and Alan B McMillan},
abstract={While Positron Emission Tomography (PET) used jointly with Magnetic Resonance (MR) Imaging shows promise in breast imaging, unique constraints require novel solutions to achieve attenuation-corrected images. We propose an algorithm for producing a linear attenuation coefficient map and truncation completion created from MR images using deep learning.}
}
@inproceedings{ISMRM2018_4329,
annote={ISMRM2018_4329},
pages={4329},
file={ISMRM2018_4329.pdf:ISMRM2018_4329.pdf:PDF},
title={Time makes the difference: Comparison of {ADC} values obtained with {OGSE} and {PGSE} sequences for differentiation of human breast tumors},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4329.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Mami Iima and Masako Kataoka and Kanae Kawai Miyake and Maya Honda and Rena Sakaguchi and Ayami Ohno Kishimoto and Mizue Suzuki and Katsutoshi Murata and Thorsten Feiweier and Masakazu Toi and Kaori Togashi},
abstract={The diffusion time dependence of ADC measurements has been investigated using OGSE and PGSE sequences in human breast tumors. Relative changes in ADC values corresponding to two diffusion times, in addition to ADC values for each diffusion time were calculated in malignant and benign breast lesions as well as in normal breast tissues. Significant differences of ADC changes, in addition to ADC values for each diffusion time, have been found among malignant and benign lesions and normal breast tissue. No ADC changes have been identified in a dedicated breast phantom. ADC maps corresponding to different diffusion times indicate that ADC changes might provide insight in revealing new tissue features like, for instance, intracellular structure of breast tumors.}
}
@inproceedings{ISMRM2018_4330,
annote={ISMRM2018_4330},
pages={4330},
file={ISMRM2018_4330.pdf:ISMRM2018_4330.pdf:PDF},
title={Quality assessment with a breast phantom and a volunteer for multi-institutional {MRI} trials including {DWI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4330.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Mami Iima and Masako Kataoka and Maya Honda and Yuta Urushibata and Ryosuke Okumura and Takashi Koyama and Kenji Uwakubo and Katsutoshi Murata and Mitsuyo Matsumoto and Yu Ueda and Kaori Togashi},
abstract={The novel method for quality control applicable for commonly used breast MR images (T1WI, T2WI and DWI) in terms of semi-quantitative and quantitative analysis was proposed. The scan was performed across multiple sites on both a breast phantom and a volunteer. The provided scores and apparent spatial resolution were comparable between a phantom and a volunteer. Quality of breast MR images across sites were variable and standardization using a dedicated breast phantom is considered necessary to assure good diagnostic performance of breast MRI.}
}
@inproceedings{ISMRM2018_4331,
annote={ISMRM2018_4331},
pages={4331},
file={ISMRM2018_4331.pdf:ISMRM2018_4331.pdf:PDF},
title={The Effect of Intravenous Administration of a Gadolinium-Based Contrast Agent on Breast Diffusion Tensor Imaging: Qualitative and Quantitative Evaluation.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4331.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Anabel M. Scaranelo and Hadassa Degani and Dov Grobgeld and Nancy Talbot and Karen Bodolai and Edna Furman-Haran},
abstract={We have investigated whether the values of the diffusion tensor imaging (DTI) parameters of breast normal tissue, as well as of benign and cancer lesions are affected by gadolinium-based contrast administration. Changes in the DTI parameters and consequently in DTI-based lesion size were evaluated pre and post dynamic contrast enhanced (DCE) MRI. Results indicated that scanning with DTI post DCE did not impact the diffusion parameters in breast normal tissue and benign lesions and the lesions’ size but revealed a significant reduction of the diffusion coefficients in breast cancers, suggesting potential improvement of DTI diagnostic specificity post-contrast.}
}
@inproceedings{ISMRM2018_4332,
annote={ISMRM2018_4332},
pages={4332},
file={ISMRM2018_4332.pdf:ISMRM2018_4332.pdf:PDF},
title={Lactate concentration measured by multiple quantum coherence ({MQC}) {MRS} in whole human breast tumour is associated with tumour grading},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4332.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Sai Man Cheung and Ehab Husain and Yazan Masannat and Klaus Wahle and Steven D Heys and Jiabao He},
abstract={High level of aerobic glycolysis and an elevated lactate accumulation have been linked to tumour aggressiveness. However, current evidence, mainly based on small animal models or biopsy sections, remains controversial. Since lactate and lipid share the same spectral frequency, conventional MRS is inadequate in measuring lactate under overwhelming lipid signal. Multiple quantum coherence (MQC) MRS allows excellent suppression of lipid even in breast tissues. We applied MQC MRS to measure lactate concentration in grade II and III freshly excised whole human breast tumours to assess if there was a difference between the two groups.}
}
@inproceedings{ISMRM2018_4333,
annote={ISMRM2018_4333},
pages={4333},
file={ISMRM2018_4333.pdf:ISMRM2018_4333.pdf:PDF},
title={Enhanced Ellipsoid Mapping of Diffusion Tensor Breast {MRI} for Improved Lesion Conspicuity},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4333.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Myra Shapiro-Feinberg and Edna Furma-Haran and Dov Grobgeld and Hadassa Degani},
abstract={Ellipsoid mapping of the breast with a specific colorization mode has been developed as a visualization means for evaluating the entire information embedded in breast Diffusion Tensor Imaging (DTI) and improve breast cancer detection. The 3D ellipsoid maps were displayed at voxel resolution with their shape and orientation determined by a respective eigenvalue-eigenvector pair of the associated diffusion tensor, followed by colorizing the ellipsoids according to the values of each diffusion tensor parameter. The results show that the enhanced ellipsoid mapping with λ1 colorization accentuating breast malignancy, may allow efficient differentiation of breast malignancy from normal breast tissue.}
}
@inproceedings{ISMRM2018_4334,
annote={ISMRM2018_4334},
pages={4334},
file={ISMRM2018_4334.pdf:ISMRM2018_4334.pdf:PDF},
title={Diagnostic Assessment of Breast Cancer in Non-Contrast {MRI} Images Through an Artificial Intelligence Machine Learning Algorithm},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4334.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Craig Neal Detheridge and Philip Saponara and Jaspreet Bhangu and Boris Nicholas Bloch and Kevin Thomas},
abstract={Contrast-Enhanced Breast MRI is a common method for diagnosis of Breast Cancer. An Artificial Intelligence Machine Learning Algorithm was developed to analyze Non-Contrast Breast MRI scans and predict diagnoses. The algorithm was trained using MRI data that had pathological specimens to validate diagnoses, obtained from The Cancer Imaging Archive. The AI was found to be 95\% accurate in classifying tissue as cancerous or benign. This algorithm could be used to assist diagnoses in clinical practice. Future work will assess the generalizability of the algorithm on data from other scan sites and the potential for classifying specific subtypes of Breast Cancer.}
}
@inproceedings{ISMRM2018_4335,
annote={ISMRM2018_4335},
pages={4335},
file={ISMRM2018_4335.pdf:ISMRM2018_4335.pdf:PDF},
title={Towards Fully Automated Breast {MR} Exams using Deep Learning},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4335.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Kang Wang and Dawei Gui and James Holmes and Alan McMillan and Leah Henze Bancroft and Roberta Strigel and Frank Korosec and Ersin Bayram},
abstract={Breast MR exams can be challenging for inexperienced MR technologists. For example, breast MRI typically requires the prescription of two carefully positioned and sized shim volumes, one for each breast, to improve the local B0 homogeneity and fat suppression. Normally, this procedure is performed manually, which requires an experienced MR technologist and can be challenging for new technologists. The goal of this project is to use deep learning to automate breast MR prescription, including placing the two shim volumes and imaging volumes automatically, to improve breast MR prescription consistency, quality and to shorten the exam time.}
}
@inproceedings{ISMRM2018_4336,
annote={ISMRM2018_4336},
pages={4336},
file={ISMRM2018_4336.pdf:ISMRM2018_4336.pdf:PDF},
title={Complementary value of End-to-end Deep Learning and Radiomics in Breast Cancer Classification on Diffusion-Weighted {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4336.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Paul F. Jaeger and Sebastian Bickelhaupt and Frederik Bernd Laun and Wolfgang Lederer and Heidi Daniel and Tristan Anselm Kuder and Stefan Delorme and Heinz-Peter Schlemmer and Franziska Steudle and Klaus Hermann Maier-Hein},
abstract={Two fundamentally different approaches have been proposed recently for the classification of breast lesions on diffusion-weighted MRI Images: “Radiomics” extracts quantitative parameters by fitting a biophysical model to the q-space signal and subsequently computes handcrafted features to feed a classifier. Convolutional neural networks on the other hand autonomously learn all processing components in an end-to-end training. To date it is unclear how the two methods compare with respect to overall performance, complementary value of features and combinability. We address these open research questions and propose a combined model that significantly outperforms the two standalone approaches.}
}
@inproceedings{ISMRM2018_4337,
annote={ISMRM2018_4337},
pages={4337},
file={ISMRM2018_4337.pdf:ISMRM2018_4337.pdf:PDF},
title={Whole-Tumor Histogram Analysis of Multiparametric {MRI} for Subtype Classification of Breast Cancer},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4337.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Tianwen Xie and Qiufeng Zhao and Robert Grimm and Caixia Fu and Yajia Gu and Weijun Peng},
abstract={Recently, several studies have shown the value of Magnetic Resonance Imaging (MRI) radiomics in non-invasive lesion subtype classification. In this study, we proposed the use of histogram texture features of multiparametric maps to differentiate subtypes of breast cancer. 34 different whole-tumor histogram features were analyzed. Classification was performed between ER-positive and Triple-negative groups resulted in AUROC of 0.94, while classification between ER-positive and HER2-positive groups and classification between HER2-positive and Triple-negative yielded AUROC of 0.79 and 0.86, respectively.}
}
@inproceedings{ISMRM2018_4338,
annote={ISMRM2018_4338},
pages={4338},
file={ISMRM2018_4338.pdf:ISMRM2018_4338.pdf:PDF},
title={In silico Platform for Evaluation of Constrained Reconstruction in {DCE}-{MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4338.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jorge E Jimenez and Leah C Henze Bancroft and Roberta Strigel and Kevin M Johnson and Scott B Reeder and Walter F Block},
abstract={In this work, we show the value of a digital phantom to evaluate a dynamic reconstruction. We evaluated the fidelity of the reconstruction using SSIM measurements from simulations and three patients to support conclusions derived from the digital phantom. The highly configurative characteristics of the in-silico platform provide a tool for other researchers to test, evaluate and compare their own acquisition and reconstruction techniques.}
}
@inproceedings{ISMRM2018_4339,
annote={ISMRM2018_4339},
pages={4339},
file={ISMRM2018_4339.pdf:ISMRM2018_4339.pdf:PDF},
title={{RF}-Induced Potential False-Negative Lesion in Breast T2-weighted {MRI} at 3T: Exploration of a Single-Channel k
T-Points Solution},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4339.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Raphael Tomi-Tricot and Vincent Gras and Thu Ha Dao and Antoine Perrot and Franck Mauconduit and Nicolas Boulant and Pierre Zerbib and Alain Rahmouni and Alexandre Vignaud and Alain Luciani and Alexis Amadon},
abstract={Breast MRI can benefit from the improved signal-to-noise ratio brought by high-field systems to achieve finer spatial or temporal resolutions. However, dielectric resonance associated with the shorter RF wavelength provokes inhomogeneous excitation in the tissues. In this work, it was shown that such artefacts can induce hyperintensity in T2-weighted images, thus potentially misleading clinicians into excluding malignancy in a lesion. A solution is proposed to reduce the RF artefact on 3D T2w acquisitions using single-transmit-channel k
T-points, which could be used on any 3T scanner.}
}
@inproceedings{ISMRM2018_4340,
annote={ISMRM2018_4340},
pages={4340},
file={ISMRM2018_4340.pdf:ISMRM2018_4340.pdf:PDF},
title={Development and Validation of {MR} Radiomics Nomogram for Preoperative Prediction of Axillary Lymph Node Metastasis in Patients With Breast Cancer},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4340.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Mei Xue and Jing Li and Shunan Che and Liyun Zhao and Yuan Tian and Lizhi Xie and Bing Wu and Xiangfei Chai and Panli Zuo and Chencui Huang},
abstract={Axillary lymph node (ALN) status is an important prognostic factor for overall breast cancer survival. The number of axillary lymph node metastases is closely related to the risk of distant metastasis1. Accurate identification of axillary lymph node involvement in patients with breast cancer is crucial for prognosis and treatment strategy decisions. Axillary lymph node dissection (ALND) is currently the standard procedure for determining ALN status. Sentinel lymph node biopsy was used to determine whether axillary lymph node dissection was needed, which is invasive2. Image based non-invasive predictors of axillary lymph nodes are highly desirable and currently face challenges. The aim of this study was to develop and validate a radiomics nomogram that incorporates both the radiomics signature and clinicopathologic risk factors for individual preoperative prediction of axillary lymph node metastasis in patients with breast cancer.}
}
@inproceedings{ISMRM2018_4341,
annote={ISMRM2018_4341},
pages={4341},
file={ISMRM2018_4341.pdf:ISMRM2018_4341.pdf:PDF},
title={Qualitative and Quantitative Assessment of Tumor Heterogeneity for the Differentiation of Molecular Subtypes in Breast Cancer},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4341.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Sunitha Thakur and Joao Vicente Horvat and Dilip Giri and Aditi Iyer and Manuela Durando and Elizabeth Morris and Katja Pinker},
abstract={Heterogeneity in breast cancer is related to aggressiveness and poor prognosis. In this study, we evaluated if qualitative visual evaluation and quantitative assessment with histogram analysis of tumor heterogeneity on diffusion weighted imaging (DWI) could be used to predict molecular subtype in invasive breast cancer. We retrospectively evaluated 91 patients with invasive ductal carcinoma. Two radiologists classified the imaging appearance of tumors on DWI according to heterogeneity. The lesions were also evaluated with histogram analysis on apparent diffusion coefficient maps. There was no statistically significant difference on heterogeneity among molecular subtypes on visual evaluation or histogram analysis.}
}
@inproceedings{ISMRM2018_4342,
annote={ISMRM2018_4342},
pages={4342},
file={ISMRM2018_4342.pdf:ISMRM2018_4342.pdf:PDF},
title={Fast intensity non-uniformity correction for breast {MRI} using sparse samples},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4342.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Linxi Shi and Steffi Liu Perkins and Catherine J Moran and Brian A. Hargreaves and Bruce L. Daniel},
abstract={The quantitative application of breast MRI is hindered by image non-uniformity artifact due to B0 and B1 variations. In this work, we developed an effective intensity non-uniformity correction algorithm for breast MRI with high computational efficiency. Compare to existing methods, the proposed method is readily implementable clinically as a software plug-in without modification of existing imaging protocols or hardware and can potentially be applied to MR images of other anatomical sites.
}
}
@inproceedings{ISMRM2018_4343,
annote={ISMRM2018_4343},
pages={4343},
file={ISMRM2018_4343.pdf:ISMRM2018_4343.pdf:PDF},
title={Examination of Lung Function among Older Smokers with and without {COPD} by Apparent Diffusion Coefficient ({ADC}) of 3He {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4343.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yanping Sun and Jia Guo and Pallavi P Balte and Stephen M Dashnaw and Martin R Prince and Elizabeth C Oelsner and Christian M Lo Cascio and Mitchell S Albert and Jim Wild and Emlyn W Hughes and R. Graham Barr},
abstract={Chronic obstructive pulmonary disease (COPD) is defined as persistent airflow limitation by spirometry. However, some smokers with normal spriometry have significant respiratory symptoms. We used 3He apparent diffusion coefficient (ADC) to examine the lungs in older smokers with and without COPD (n=50). This study showed high ADC in both smokers with and without COPD. The difference in ADC between COPD and non-COPD was significant. ADC was correlated positively with percent emphysema and \%FVC and negatively with FEV1 to FVC ratio and, non-significantly with FEV1. 3He ADC may provide different information of lung microarchitecture from spirometry in smoking related pulmonary diseases.}
}
@inproceedings{ISMRM2018_4344,
annote={ISMRM2018_4344},
pages={4344},
file={ISMRM2018_4344.pdf:ISMRM2018_4344.pdf:PDF},
title={Lung cancer screening with {MRI}: characterization of nodules with different non-enhanced {MRI} sequences.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4344.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Michael Meier-Schroers and Rami Homsi and Hans Heinz Schild and Daniel Thomas},
abstract={Due to increased interest in pulmonary MRI as a radiation free alternative to CT for lung cancer screening, we analyzed MRI characteristics of pulmonary nodules with different non-enhanced sequences.}
}
@inproceedings{ISMRM2018_4345,
annote={ISMRM2018_4345},
pages={4345},
file={ISMRM2018_4345.pdf:ISMRM2018_4345.pdf:PDF},
title={Clinical Feasible Breath-Hold Lung Imaging Using Zero Echo Time {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4345.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Chien-Yuan Eddy Lin and Hsiao-Ling Lin and Charng-Chyi Shieh and Chia-Wei Li and Wing P. Chan},
abstract={A high resolution, rapid scanning in one breath-hold and three-dimensional zero-echo time protocol for lung imaging was established in this study. It successfully captured rapid-decaying lung signal and eliminated the motion artifact and consequently exhibit high quality of pulmonary anatomy, including the tortuous vessels architecture and bronchial wall in exceptional clarity and detail. Additionally, it provides the volume estimation of pulmonary tissue and shows somewhat comparable with the calculation result from computed tomography.}
}
@inproceedings{ISMRM2018_4346,
annote={ISMRM2018_4346},
pages={4346},
file={ISMRM2018_4346.pdf:ISMRM2018_4346.pdf:PDF},
title={Functional lung imaging with partially spoiled ultra-fast steady-state free precession at 1.5T and 3T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4346.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Grzegorz Bauman and Orso Pusterla and Oliver Bieri},
abstract={In this work we propose an alternative acquisition framework for functional lung imaging using matrix pencil (MP) decomposition (a derivative of Fourier decomposition method) based on partially spoiled ultra-fast steady-state free-precession (ps-ufSSFP) imaging. We showed that MP decomposition is feasible in healthy volunteers using ps-ufSSFP at 1.5T and 3T. Hence, ps-ufSSFP can be a viable solution for the application of MP MRI at 3T where imaging with balanced ufSSFP can be problematic due to the occurrence of off-resonance artifacts.}
}
@inproceedings{ISMRM2018_4347,
annote={ISMRM2018_4347},
pages={4347},
file={ISMRM2018_4347.pdf:ISMRM2018_4347.pdf:PDF},
title={Quantification of Pulmonary Perfusion in Idiopathic Pulmonary Fibrosis: Preliminary Results},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4347.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Luis A Torres and Wei Zha and Mu He and Bastiaan Driehuys and Sean B Fain},
abstract={IPF is a pulmonary disease with no validated biomarkers in current clinical use. Here, we compared pulmonary perfusion in an IPF subject versus healthy subject using Dynamic Contrast-Enhanced MRI (DCE-MRI). A decrease in PBF, PBV and an increase in MTT was seen in IPF compared to the healthy control. High spatial correlation of perfusion defects and fibrosis is seen when compared to the morphological images, suggesting DCE-MRI may prove to be a useful technique for evaluating IPF.}
}
@inproceedings{ISMRM2018_4348,
annote={ISMRM2018_4348},
pages={4348},
file={ISMRM2018_4348.pdf:ISMRM2018_4348.pdf:PDF},
title={Diffusion kurtosis imaging in solitary pulmonary nodules: comparison with quantitative dynamic contrast enhanced {MR} imaging in malignant and benign pulmonary nodule differentiation},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4348.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Shuchang Zhou and Liming Xia and Xu Yan},
abstract={Theoretically, DKI and quantitative DCE-MRI can provide more precise microstructure and perfusion information of tissues. However, the two methods had rarely been reported in solitary pulmonary nodules (SPNs) to date, so we collected 37 patients with SPNs underwent both DKI and DCE-MRI and measured relative parameters. The Kapp, Ktrans, Ve and iAUC values were significantly higher in lung cancer than in benignity. Kapp had best sensitivity and accuracy and iAUC had best specificity. The combination of both methods can provide a robust way to discriminate SPNs before clinical management.}
}
@inproceedings{ISMRM2018_4349,
annote={ISMRM2018_4349},
pages={4349},
file={ISMRM2018_4349.pdf:ISMRM2018_4349.pdf:PDF},
title={Markov Model of Lung Cancer Screening Demonstrates Equivalent Lung Cancer Detection using either Lung {MRI} or Low-Dose {CT} Screening Strategies},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4349.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Bradley D Allen and Mark L Schiebler and Hans-Ulrich Kauczor and Jürgen Biederer and Timothy J Kruser and Nisha A Mohindra and David D Odell and James C Carr and Gorden B Hazen},
abstract={Lung cancer screening with low dose CT (LDCT) has been shown to result in a 20\% mortality reduction, but has relatively low specificity for lung cancer diagnosis, as well as concerns related to radiation dose and overdiagnosis. Lung MRI has similar sensitivity and improved specificity for lung cancer detection. In this study, we developed a Markov model of lung cancer screening to compare performance of LDCT and MRI. Based on our analysis, lung cancer screening with MRI could provide an equivalent number of lung cancer diagnoses, while dramatically reducing the number of false positive findings relative to LDCT.}
}
@inproceedings{ISMRM2018_4350,
annote={ISMRM2018_4350},
pages={4350},
file={ISMRM2018_4350.pdf:ISMRM2018_4350.pdf:PDF},
title={Robust Retrospective Respiratory Gating for Detection of Small Pulmonary Nodules with {UTE} {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4350.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Naoharu Kobayashi and Abbie Begnaud and Tadashi Allen and Gregory J. Metzger and Robert Kratzke and Michael Garwood},
abstract={Retrospective respiratory gating using a 3D time series lung image reconstructed with sub-second temporal resolution is introduced to achieve accurate small pulmonary nodule detection with ultrashort echo time (UTE) MRI. Changes of the diaphragmatic level during free breathing were tracked using the 3D time series lung image. With the extracted respiratory motion, the data in exhalation were reconstructed to a high resolution image. The feasibility and robustness of the proposed retrospective gating method were tested by surveilling incident lung nodules in two UTE MRI examinations: a baseline scan and a follow-up scan in 10 weeks.}
}
@inproceedings{ISMRM2018_4351,
annote={ISMRM2018_4351},
pages={4351},
file={ISMRM2018_4351.pdf:ISMRM2018_4351.pdf:PDF},
title={A new diagnostic method for Pneumothorax:3D-{UTE} {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4351.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Can HUANG and Yang FAN and Tao JIANG},
abstract={Radiation may has great impact on teenagers who are the high risk population for pneumothorax. Compared to X-ray and CT, MRI is a imaging modality without radiation. The purpose of this study is to examine the feasibility of using UTE MRI to diagnose the pneumothorax.}
}
@inproceedings{ISMRM2018_4352,
annote={ISMRM2018_4352},
pages={4352},
file={ISMRM2018_4352.pdf:ISMRM2018_4352.pdf:PDF},
title={Dynamic contrast-enhanced {MRI} for the evaluation of perfusion heterogeneity in idiopathic pulmonary fibrosis},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4352.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Nicholas David Weatherley and Helen Marshall and Paul Hughes and Jody Bray and David Capener and Matthew Austin and Laurie Smith and Stephen Renshaw and Stephen Bianchi and Jim Wild},
abstract={Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) produces metrics of lung perfusion at the capillary level. To date, little assessment of patients with idiopathic pulmonary fibrosis (IPF) has been reported with DCE-MRI. In fourteen patients with IPF, we found that regions of low flow and high transit times were associated with anatomical disease. Whole lung metrics of transit time and heterogeneity of blood volume demonstrated a relationship with pulmonary function tests. Such functional imaging strategies may be useful in quantifying functional changes in the pulmonary vasculature in IPF.}
}
@inproceedings{ISMRM2018_4353,
annote={ISMRM2018_4353},
pages={4353},
file={ISMRM2018_4353.pdf:ISMRM2018_4353.pdf:PDF},
title={Longitudinal assessment of changes in lung microstructure in idiopathic pulmonary fibrosis with hyperpolarized gas diffusion-weighted {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4353.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ho-Fung Chan and Nicholas D. Weatherley and Neil J. Stewart and Guilhem J. Collier and Stephen Bianchi and Jim M. Wild},
abstract={Apparent diffusion coefficient (ADC) calculated from hyperpolarized gas diffusion-weighted (DW)-MRI has been shown to be elevated in lungs afflicted with idiopathic pulmonary fibrosis (IPF). This work assesses the sensitivity of
3He DW-MRI metrics to longitudinal changes in IPF patients by evaluating
3He ADC and mean diffusive length scale (Lm
D) from the stretched exponential model at baseline, 6 and 12 months. ADC was not significantly different between visits, but a statistically significant increase of 13 µm in Lm
D was observed after 12 months suggesting multiple b-value DW-MRI is sensitive to progressive microstructural changes in the lungs in IPF.}
}
@inproceedings{ISMRM2018_4354,
annote={ISMRM2018_4354},
pages={4354},
file={ISMRM2018_4354.pdf:ISMRM2018_4354.pdf:PDF},
title={A Comparison of Hyperpolarized Helium-3 and Xenon-129 {MR} Fractional Ventilation Imaging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4354.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Hooman Hamedani and Kai Ruppert and Yi Xin and Stephen Kadlecek and Faraz Amzajerdian and Ryan Baron and Ian Duncan and Luis Loza and Mehrdad Pourfathi and Sarmad Siddiqui and Harrilla Profka and Mary Spencer and Tahmina Achekzai and Maurizio Cereda and Rahim R. Rizi},
abstract={In response to the global shortage of
3He, we studied the feasibility and safety of performing a multi-breath wash-in MR imaging technique to measure fractional ventilation using hyperpolarized (HP)
129Xe in the same manner as with
3He.}
}
@inproceedings{ISMRM2018_4355,
annote={ISMRM2018_4355},
pages={4355},
file={ISMRM2018_4355.pdf:ISMRM2018_4355.pdf:PDF},
title={Deep Learning Lung Segmentation in Paediatric Patients},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4355.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Orso Pusterla and Simon Andermatt and Grzegorz Bauman and Sylvia Nyilas and Philipp Madörin and Tanja Haas and Simon Pezold and Francesco Santini and Philipp Latzin and Philippe Claude Cattin and Oliver Bieri},
abstract={Automatic lung segmentation of MR images is challenging; especially in the presence of pathologies. In this work, we tackle lung segmentation of 2D and 3D ultra-fast steady-state free precession MRI in cystic fibrosis patients by using deep learning based on a neural network of multi-dimensional gated recurrent units.}
}
@inproceedings{ISMRM2018_4356,
annote={ISMRM2018_4356},
pages={4356},
file={ISMRM2018_4356.pdf:ISMRM2018_4356.pdf:PDF},
title={3D T1 mapping in the lungs during free breathing using asymmetrical cylindrical encoding},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4356.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Simon MF Triphan and Mark O Wielpütz and Hans-Ulrich Kauczor and Bertram J Jobst},
abstract={T1 in the lungs has been found to be interesting both for oxygen enhanced imaging and as a biomarker in COPD. In this work, T1 mapping in human lungs was implemented using a cylindrically encoded 3D measurement using asymmetric radial encoding in an inversion recovery experiment. Breathing was compensated by employing DC-gating with the MR signal, using a correction to cancel the influence of the inversion recovery. It is shown that using a segmented scheme for 3D phase encoding steps that spreads steps over k-space while minimizing leaps in T1-weighting improves gating performance and thus the resulting T1 maps.}
}
@inproceedings{ISMRM2018_4357,
annote={ISMRM2018_4357},
pages={4357},
file={ISMRM2018_4357.pdf:ISMRM2018_4357.pdf:PDF},
title={Automatic Segmentation of Lung Anatomy from Proton {MRI} based on a Deep Convolutional Neural Network},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4357.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Xue Feng and Nicholas J. Tustison and Renkun Ni and Zixuan Lin and John P. Mugler, III and Craig H. Meyer and Talissa A. Altes and Joanne M. Cassani and Y. Michael Shim and Kun Qing},
abstract={With rapid development of pulmonary MRI techniques, increasingly useful morphological and functional information can be obtained, such as pulmonary perfusion, ventilation and gas uptake through hyperpolarized-gas MRI. Identification of lung anatomy is usually the first step for quantitative analysis. In the work, we proposed and validated a new approach for automatic segmentation of lung anatomy from proton MRI based on 3D U-Net structure. The new method had a relatively consistent performance in all subjects (dice overlap 0.90-0.97). Its future application for anatomical based analysis of structural and/or functional pulmonary MRI data needs further validation in larger number of data.}
}
@inproceedings{ISMRM2018_4358,
annote={ISMRM2018_4358},
pages={4358},
file={ISMRM2018_4358.pdf:ISMRM2018_4358.pdf:PDF},
title={Correction for Ventilation Quantification Errors due to Registration in Pulmonary Lung {MRI} Fourier Decomposition},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4358.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Filip Klimeš and Andreas Voskrebenzev and Marcel Gutberlet and Agilo Kern and Lea Behrendt and Till Kaireit and Alexander Rotärmel and Julius Renne and Christian Schönfeld and Frank Wacker and Jens Vogel-Claussen},
abstract={Ventilation-perfusion (V/Q) scan plays an important role in the assessment of lung function. Currently, Fourier Decomposition (FD), a method for simultaneous ventilation and perfusion measurement, uses fractional ventilation (FV) as a semi-quantitative measurement of lung ventilation. Just recently, a multi-echo spoiled gradient echo sequence method for regional alveolar ventilation (AV) measurement with FD was presented. This study demonstrates that both methods suffer from an artificial proton amount change during registration, which affects quantification. Correction factors are derived for both methods and used to compare AV and FV measurement. Additionally, the regional influence of T
2* correction is assessed.}
}
@inproceedings{ISMRM2018_4359,
annote={ISMRM2018_4359},
pages={4359},
file={ISMRM2018_4359.pdf:ISMRM2018_4359.pdf:PDF},
title={Multiparametric Approach by Quantitatively Assessed Dynamic First-Pass Contrast-Enhanced Perfusion {MRI} with {FDG}-{PET}/{CT}: Capability for Therapeutic Response Prediction in Non-Small Cell Lung Cancer After Conservative Therapy},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4359.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yoshiharu Ohno and Masao Yui and Shigeharu Ohyu and Yuji Kishida and Shinichiro Seki and Katsusuke Kyotani and Takeshi Yoshikawa},
abstract={To the best of our knowledge, no studies have been reported of a direct comparison of dynamic CE-perfusion MRI with PET/CT for therapeutic effect prediction for NSCLC patients treated with chemoradiotherapy. We hypothesized that multiparametric approach of quantitatively assessed dynamic CE-perfusion MRI with PET/CT have potential for better therapeutic effect prediction than single parametric methods by both modalities in NSCLC patients treated with chemoradiotherapy. The purpose of this study was therefore to directly compare the capability for therapeutic response prediction by among quantitatively assessed dynamic CE-perfusion MRI, FDG-PET/CT and multiparametric approach by both modalities in NSCLC patients treated with chemoradiotherapy.}
}
@inproceedings{ISMRM2018_4360,
annote={ISMRM2018_4360},
pages={4360},
file={ISMRM2018_4360.pdf:ISMRM2018_4360.pdf:PDF},
title={Multi- and Sigle Parametric Approaches using Chemical Exchange Saturation Transfer ({CEST}) Imaging, Diffusion-Weighted Imaging and {FDG}-{PET}/{CT} for Pulmonary Nodule Diagnosis},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4360.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yoshiharu Ohno and Masao Yui and Mitsue Miyazaki and Yuji Kishida and Shinichiro Seki and Katsusuke Kyotani and Takeshi Yoshikawa},
abstract={No major reports have been reported the capability for differentiating malignant and benign pulmonary lesions among multi- and single parametric approaches by CEST imaging, DWI and PET/CT. We hypothesized that multi parametric approach by all three techniques had better potential for diagnosis of pulmonary nodule than single parametric approach, when applied with CEST imaging, DWI and FDG-PET/CT. The purpose of this study was to directly and prospectively compare the capability for differentiating of malignant from benign pulmonary nodules between multi- and single-parametric approaches by CEST, DWI and FDG-PET/CT.}
}
@inproceedings{ISMRM2018_4361,
annote={ISMRM2018_4361},
pages={4361},
file={ISMRM2018_4361.pdf:ISMRM2018_4361.pdf:PDF},
title={Quantification of Hyperpolarized 3He {MRI} Ventilation Heterogeneity in Asthmatics: Surface Area of Ventilation Clusters},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4361.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Andrew Westcott and Rachel L Eddy and Dante PI Capaldi and Heather M Young and David G McCormack and Grace Parraga},
abstract={Ventilation heterogeneity measured using hyperpolarized noble-gas magnetic-resonance imaging (MRI), presents a significant challenge in terms of the need for imaging processing tools to generate rapid, reproducible, intuitive and clinically relevant biomarkers. In particular, new tools are needed to differentiate ventilation defects and patchy ventilation that likely represent different functional phenotypes. Therefore, here we developed a new way to quantify MRI ventilation heterogeneity using the surface area between ventilation clusters – the ratio of surface area to ventilation volume (SAVV) measured in units of mm
-1. MRI SAVV was significantly greater in severe asthmatics (n=24), as compared to mild-to-moderate asthmatics (n=16).}
}
@inproceedings{ISMRM2018_4362,
annote={ISMRM2018_4362},
pages={4362},
file={ISMRM2018_4362.pdf:ISMRM2018_4362.pdf:PDF},
title={Discovery and Verification of Lung Cancer Serum Biomarkers using Paired Tissue and Serum},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4362.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Leo L. Cheng and Isabella Dittmann and Li Su and Johannes Kurth and Andreas Schuler and Yannick Berker and Lindsey A. Vandergrift and Sarah S. Dinges and Piet Habbel and Eugene J. Mark and David C. Christiani},
abstract={A widespread, minimally-invasive method for early detection of lung cancer is urgently needed in the lung cancer clinic. Using high resolution magic angle spinning magnetic resonance spectroscopy, we measured paired tissue and serum samples from the same patients. We correlated serum and tissue results to discover and verify serum markers for lung cancer types and stages and predicted overall survival for early Stage I lung cancer. Measured from serum, prolonged survival is associated with relative overexpression of glutamine, valine, glycine and relative suppression of glucose and lipids.}
}
@inproceedings{ISMRM2018_4363,
annote={ISMRM2018_4363},
pages={4363},
file={ISMRM2018_4363.pdf:ISMRM2018_4363.pdf:PDF},
title={Pulmonary Ventilation Imaging in Cystic Fibrosis Using Oxygen-enhanced {MRI}: Comparison with Hyperpolarized Helium-3 {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4363.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Wei Zha and Robert V Cadman and Scott K Nagle and Sean B Fain},
abstract={Recent technical advances in oxygen-enhanced (OE) MRI using 3D radial UTE sequence support quantitative differentiation of diseased vs healthy lungs using ventilation defect percent (VDP). A cohort of cystic fibrosis (CF) subjects with different disease severities underwent spirometry, hyperpolarized (HP) 3He and OE-MRI and a subset of those returned for a repeat visit 1-2 weeks later. The results suggest global VDP measures from HP- and OE-MRI were correlated (ρ=0.80, p<0.0001) with comparable test-retest repeatability, showed similar correlation with spirometry. Moreover, UTE OE-MRI with isotropic spatial resolution provides both structural and functional evaluations of obstructed lungs.}
}
@inproceedings{ISMRM2018_4364,
annote={ISMRM2018_4364},
pages={4364},
file={ISMRM2018_4364.pdf:ISMRM2018_4364.pdf:PDF},
title={Pulmonary nodule detection using ultra-short {TE} ({UTE}) with a 3D variable-{TE} stack-of-spirals sequence},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4364.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yu-Sen Huang and Emi Niisato and Mao-Yuan Marine Su and Alto Stemmer and Jin-Shing Chen and Yeun-Chung Chang},
abstract={UTE with 3D variable-TE stack-of-spirals sampling has been developed recently and allows shorter scan times by using undersampling in combination with an iterative, self-consistent parallel imaging reconstruction (SPIRiT). The goal of this study was to investigate the feasibility of this new technique in patients for detecting pulmonary nodules. The sequence was optimized for both free-breathing and breath-holding. Compared with CT images, the detection rate for pulmonary nodules in the UTE images was 92\% for free-breathing and 75\% for breath-holding. Our results suggest that the proposed UTE sequence has the capacity to detect pulmonary nodules under both free-breathing and breath-holding conditions.}
}
@inproceedings{ISMRM2018_4365,
annote={ISMRM2018_4365},
pages={4365},
file={ISMRM2018_4365.pdf:ISMRM2018_4365.pdf:PDF},
title={{MR} imaging of the lung with a respiratory-gated ultrashort echo time ({UTE}) sequence with spiral acquisition technique: A feasibility study in oncology patients},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4365.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Min Jae Cha and Hyun Jeong Park and Eun Sun Lee and Sung Bin Park and Yang Soo Kim and Byung In Choi},
abstract={We have demonstrated the feasibility of respiratory-gated ultrashort echo time sequence with spiral acquisition technique (spiral UTE; 1.5-mm isotropic resolution; echo time, 0.05 msec) of the lung for pulmonary nodule detection in oncology patients. Overall nodule detection rate was 86\% (43 of 50 nodules) and the detection rate for nodules of ≥5 mm was 100 \% (20 of 20 nodules). Mean acquisition time for spiral UTE was 327 seconds (range, 300 – 465 seconds). We think that spiral UTE could be a potential alternative to chest CT in oncology patients, who are in the risk of inevitable radiation exposure.
}
}
@inproceedings{ISMRM2018_4366,
annote={ISMRM2018_4366},
pages={4366},
file={ISMRM2018_4366.pdf:ISMRM2018_4366.pdf:PDF},
title={Texture Analysis in Magnetic Resonance Fingerprinting of the Prostate: Utility for Differentiation of Grade and Cancer from Non-cancerous tissue.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4366.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Samuel Frankel and Ananya Panda and Debra McGivney and Gregory O'Connor and Alice Yu and Mark Griswold and Chaitra Badve and Vikas Gulani},
abstract={Prostate cancer and prostatitis can have considerable overlap on conventional MR imaging. Texture analysis on multiparametric MRI shows promise in characterization of prostate, but has not been used on quantitative prostate maps. Here we utilize texture analysis on magnetic resonance fingerprinting (MRF) maps of prostate for characterization of prostate lesions. Results show that texture features can differentiate cancer and non-cancerous transition zone and between grades of cancer in peripheral zone. This could add value to MRF-based relaxometry and conventional MRI to improve lesion characterization.}
}
@inproceedings{ISMRM2018_4367,
annote={ISMRM2018_4367},
pages={4367},
file={ISMRM2018_4367.pdf:ISMRM2018_4367.pdf:PDF},
title={Multiparametric {MRI} Radiomic Signatures: Individual Prediction for Prostate Cancer and Benign lesions with same imaging findings},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4367.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Min Xu and Xiangming Fang and Mengjie Fang and Di Dong and Jie Tian and Zhongshuai Zhang},
abstract={Quantitative Radiomic features based on multiparametric Magnetic Resonance Imaging have great clinical value in discriminating prostate cancer and benign lesions with same imaging findings. We extracted Radiomic features and compared the discrimination efficiency of the combined three types of images with each single type of images, then incorporated independent clinical risk factors and further developed an individual prediction model. The experimental results show that the individual prediction model achieved more accurate diagnosis results than only using Radiomic signatures or clinical factors}
}
@inproceedings{ISMRM2018_4368,
annote={ISMRM2018_4368},
pages={4368},
file={ISMRM2018_4368.pdf:ISMRM2018_4368.pdf:PDF},
title={{MR} texture analysis: potential imaging biomarker for prediction of chemotherapy response in patients with colorectal liver metastases},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4368.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Huan Zhang and Wenhua Li and Feixiang Hu and Yiqun Sun and Tingdan Hu and Tong Tong},
abstract={The aim of this study was to determine if pre-treated MR texture features of colorectal liver metastases (CRLMs) are predictive of chemotherapy response after the first-line chemotherapy. The results indicate that MR texture features on pre-treated T2 images seem to be a promising tool for predicting the chemotherapy response of patients with colorectal liver metastases.}
}
@inproceedings{ISMRM2018_4369,
annote={ISMRM2018_4369},
pages={4369},
file={ISMRM2018_4369.pdf:ISMRM2018_4369.pdf:PDF},
title={Evaluation the Feasibility of Integrating Computer-aided Diagnosis as a Second Reader into Prostate Multiparametric {MRI} Diagnostic Process},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4369.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Lina Zhu and Ge Gao and Xiaoying Wang and Jing Liu and Rui Wang and Kai Zhao and Yuan Jiang},
abstract={Computer-aided diagnosis (CAD) for prostate cancer (PCa) detection based on multiparametric MRI (mpMRI) has become an active field of research, which has shown good stand-alone performance. Before its widely use in daily clinical work, further study still should be done for CAD reading paradigm and the interaction between CAD and human reader. In this article, we implemented CAD in the real world practice, aiming to evaluate the feasibility of integrating CAD as a second reader into the clinical diagnostic process. The results showed this reading paradigm was feasible and CAD might help readers detect more patients with PCa.}
}
@inproceedings{ISMRM2018_4370,
annote={ISMRM2018_4370},
pages={4370},
file={ISMRM2018_4370.pdf:ISMRM2018_4370.pdf:PDF},
title={How often is the Dynamic Contrast Enhanced ({DCE}) score needed in {PI}-{RADS} version 2?},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4370.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Albert T Roh and Andreas M Loening and Richard E Fan and Geoffrey Sonn and Shreyas S Vasanawala},
abstract={The value of the Dynamic Contrast Enhanced (DCE) sequence in scoring a prostate lesion using PI-RADS version 2 is unknown. Our retrospective review of 213 patients who underwent prostate MRI and subsequent biopsy determined that the rate at which DCE was needed for obtaining the final PI-RADS score was 9\%. This low rate raises the possibility of limiting the initial screening prostate MRI to an abbreviated non-contrast protocol, calling back the patient for the DCE sequence only if the initial exam is equivocal.}
}
@inproceedings{ISMRM2018_4371,
annote={ISMRM2018_4371},
pages={4371},
file={ISMRM2018_4371.pdf:ISMRM2018_4371.pdf:PDF},
title={Multi-parametric {MRI} features and pathologic outcome of wedge shaped lesions on T2-weighted images},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4371.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Aritrick Chatterjee and Sevil Tokdemir and Alexander J Gallan and Shiyang Wang and Ambereen Yousuf and Tatjana Antic and Gregory S Karczmar and Aytekin Oto},
abstract={This study investigated the multi-parametric MRI features and pathologic outcome of wedge shaped lesions on T2-weighted images in 76 patients. A greater percentage of wedge shaped features were found to be malignant than shown previously. Malignant wedge shaped regions were primarily highly hypointense on ADC maps and showed early enhancement on DCE-MRI. Benign wedge shaped lesions were predominantly mildly hypointense on ADC maps and showed no early enhancement and pathologically outcome showed prostatitis, hemosiderin-laden macrophages, prominent blood vessels, intraluminal blood and atrophy. Malignant wedge shaped lesions were found to have significantly lower ADC compared to benign wedge shaped regions.}
}
@inproceedings{ISMRM2018_4372,
annote={ISMRM2018_4372},
pages={4372},
file={ISMRM2018_4372.pdf:ISMRM2018_4372.pdf:PDF},
title={Differentiating prostate cancer from benign prostatic hyperplasia using multiparametric {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4372.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Aritrick Chatterjee and Alexander J Gallan and Dianning He and Xiaobing Fan and Devkumar Mustafi and Ambereen Yousuf and Tatjana Antic and Gregory S Karczmar and Aytekin Oto},
abstract={This study investigates multiparametric MRI (mpMRI) appearance of different types of BPH and whether quantitative mpMRI is effective in differentiating between PCa and BPH in 60 patients. mpMRI and specifically quantitative ADC values can be used for differentiating PCa and BPH, improving PCa diagnosis in the transition zone. However, DCE-MRI metrics are not effective in distinguishing PCa and BPH. In contrast to previous understanding, glandular BPH has short T2 values (hypointense on T2-weighted images), demonstrates restricted diffusion and may have similar quantitative mpMRI measurements to stromal BPH. Additionally, glandular and cystic BPH appear differently on mpMRI and are histologically different.}
}
@inproceedings{ISMRM2018_4373,
annote={ISMRM2018_4373},
pages={4373},
file={ISMRM2018_4373.pdf:ISMRM2018_4373.pdf:PDF},
title={Diagnosis of Prostate Cancer using {MRI} derived quantitative Risk Maps},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4373.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Aritrick Chatterjee and Dianning He and Xiaobing Fan and Tatjana Antic and Ajit Devaraj and Yulei Jiang and Gregory S Karczmar and Aytekin Oto},
abstract={This study develops a new tool that estimates the risk map for prostate cancer using quantitative mpMRI metrics and investigates the feasibility of this tool in screening for PCa. Quantitative mpMRI parameters: ADC, T2 and DCE signal enchantment values were calculated and subsequently cancer presence was predicted based on estimated risk scores. The sensitivity, specificity, positive predictive value and negative predictive value for PCa detection using a sector based analysis were 75.0\%, 88.6\%, 84.7\% and 80.8\% respectively. The area under the curve in ROC analysis was 0.818. Importantly, all the index lesions were identified by the risk map tool.}
}
@inproceedings{ISMRM2018_4374,
annote={ISMRM2018_4374},
pages={4374},
file={ISMRM2018_4374.pdf:ISMRM2018_4374.pdf:PDF},
title={The effects of dutasteride on quantitative T2 and T2-weighted imaging in men on active surveillance for prostate cancer: results from a placebo-controlled, randomized clinical trial},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4374.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Francesco Giganti and Giulio Gambarota and Caroline M Moore and Neil McCartan and Mark Emberton and Clare Allen and Alex Kirkham},
abstract={We investigated MRI changes in quantitative T2 parameters in lesions and healthy tissue in men on active surveillance (AS) for prostate cancer (PCa) taking dutasteride or placebo for six months. The protocol included a multi-echo sequence for quantification of the T2 relaxation times. A synthetic signal contrast (T2Q) between lesion and healthy tissue was assessed using quantitative T2 values. Signal contrast was calculated using T2-weighted sequence (T2W contrast). No differences for T2W contrast were observed. A significant correlation between T2Q and T2W contrast was shown. Dutasteride does not influence T2 contrast and relaxation in men on AS for PCa.}
}
@inproceedings{ISMRM2018_4375,
annote={ISMRM2018_4375},
pages={4375},
file={ISMRM2018_4375.pdf:ISMRM2018_4375.pdf:PDF},
title={Quantitative T2 values for Detection and Grading of Prostate Cancer},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4375.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Tobias Franiel and Julia Mai and Mohamed Abubrig and Thomas Lehmann and Felix Güttler and Elisabeth Weiland and Tom Hilbert and René Aschenbach and Friedrich-Carl von Rundstedt and Marc-Oliver Grimm and Ulf Teichgräber},
abstract={
Purpose: Determination of quantitative T2 values in prostate tissue and their evaluation for detection and grading of prostate cancer.
Methods: 3T T2 maps and ADC maps of 75 patients with 857 prostate areas (378x normal, 177x cancer, 150x BPH, 119x prostatitis and 33x precancer) were determined.
Results: T2 values differed significantly between cancer and normal (AUC=0.871), between cancer and BPH (AUC=0.827) and between cancer with GleasonScore 6 and ≥ 7 (AUC=0.742). T2 relaxivities decreased with increasing GleasonScore and correlated significantly with ADC-values (r=0.772).
Conclusion: T2 values seem to be adequate for the differentiation between prostate cancer and normal tissue or BPH.}
}
@inproceedings{ISMRM2018_4376,
annote={ISMRM2018_4376},
pages={4376},
file={ISMRM2018_4376.pdf:ISMRM2018_4376.pdf:PDF},
title={Does Machine Learning, As An Independent Arbitrator Of {MR} Contrast-Ranking In Prostate Cancer Exams, Agree With {PI}-{RADS} version 2?},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4376.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Steve Patterson and Peter Lee and Chris V. Bowen and Jennifer Merrimen and Cheng Wang and Steven D. Beyea and Sharon E. Clarke},
abstract={We show that a simple machine learning algorithm validated most, but not all, aspects of the Prostate Imaging Reporting and Data System (PI-RADS) version 2 formalism derived exclusively from clinical perspectives. Specifically, the value of diffusion-weighted imaging (DWI) and dynamic contrast-enhanced (DCE) sequences in the peripheral zone was confirmed. In contradistinction to PI-RADS, DWI was found to be more valuable in the transition zone than T2 weighted imaging; however, a T2 texture feature afforded a small but significant increase in classifier accuracy in this zone.}
}
@inproceedings{ISMRM2018_4377,
annote={ISMRM2018_4377},
pages={4377},
file={ISMRM2018_4377.pdf:ISMRM2018_4377.pdf:PDF},
title={Detection of Clinically Significant Prostate Cancer: Incremental Value of Deep Learning to {PI}-{RADS} V2},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4377.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Liang Wang},
abstract={Deep learning has great potential in medical imaging. 168 patients underwent 3T mpMRI of prostate before mpMR-targeted biopsies plus systematic sampling. Two radiologists from two separate institutions, by using the Prostate Imaging Reporting and Data System (PI-RADS) V2 and a multimodal convolutional neural networks (CNN)-based deep learning, independently assessed prostate MRI examinations. Histopathologic findings were used as the reference standard. In detecting csPCa, both reviewers had significantly higher AUCs using CNN-based deep learning. Reviewer 2 benefited much more from CNN-based deep learning than did reviewer 1. Combined PI-RADS with CNN-based deep learning contribute significant incremental value in the detection of csPCa.}
}
@inproceedings{ISMRM2018_4378,
annote={ISMRM2018_4378},
pages={4378},
file={ISMRM2018_4378.pdf:ISMRM2018_4378.pdf:PDF},
title={Feasibility of {USPIO} enhanced 7 Tesla {MRI} for detecting lymph node metastases in prostate cancer},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4378.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Bart WJ Philips and Rutger CH Stijns and Sören Johst and Stephan Orzada and Ansje S Fortuin and Jelle O Barentsz and Marnix C Maas and Tom WJ Scheenen},
abstract={Ultrahigh field MRI offers opportunities for USPIO enhanced MRI for diagnosing lymph node metastases in prostate cancer, by improving resolution and increasing the sensitivity to USPIO particles. The assessment of lymph nodes based on size, shape and USPIO uptake can improve the differentiation between non-cancer and metastatic lymph nodes and may also lower the detection size limit for metastatic nodes. In this work we show the first results of USPIO enhanced MRI and computed echo time imaging of patients with high risk prostate cancer at 7 Tesla.}
}
@inproceedings{ISMRM2018_4379,
annote={ISMRM2018_4379},
pages={4379},
file={ISMRM2018_4379.pdf:ISMRM2018_4379.pdf:PDF},
title={Use of Texture Analysis to Predict Prostate Artery Embolization Outcomes with {MR} imaging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4379.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Susanna E Kallioinen and Terence A Jones and James Harding and Manpreet Dhillon and Sachin Modi and Nigel Hacking and Drew Maclean and Charles E Hutchinson},
abstract={Pre-prostate artery embolization (PAE) magnetic resonance images (MRI) from patients with benign prostatic hypertrophy (BPH) were segmented and analysed using two different texture analysis software, qMaZda and TexRad. Percentage reduction in prostate volume and percentage reduction in the International Prostate Symptom Score (IPSS) were used as MRI based outcome measures to build models to be able to predict outcomes from PAE. MRI texture analysis using qMaZda with a linear regression model is able to somewhat predict the percentage prostate volume reduction three months after PAE but not the percentage reduction in IPSS.}
}
@inproceedings{ISMRM2018_4380,
annote={ISMRM2018_4380},
pages={4380},
file={ISMRM2018_4380.pdf:ISMRM2018_4380.pdf:PDF},
title={Utility of Multiparametric Prostate Magnetic Resonance Imaging for Prediction of Treatment Response Following Focal Laser Ablation},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4380.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ely Felker and Leonard Marks and Fuad Elkhoury and David S Lu and Daniel Margolis and Shyam Natarajan and James Sayre and Steven Raman},
abstract={We evaluated the utility of multiparametric prostate MRI, including T2-weighted imaging, diffusion-weighted imaging (DWI) and dynamic contrast-enhanced imaging, in predicting treatment response following focal laser ablation of prostate cancer in a multi-reader study. DWI appears to be the most useful sequence in response assessment, but inter-reader agreement was moderate at best.}
}
@inproceedings{ISMRM2018_4381,
annote={ISMRM2018_4381},
pages={4381},
file={ISMRM2018_4381.pdf:ISMRM2018_4381.pdf:PDF},
title={Preliminary Investigation of {MR} Elastography to Predict Lymph Node Metastasis in Prostate Cancer},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4381.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jin Wang and TianHui Zhang and Ying Deng and Sichi Kuang and Bingjun He and Qungang Shan and Jun Chen and Phillip Rossman and Arvin Arani and Xin Gao and Ziying Yin and Meng Yin and Kevin J. Glaser and Richard L. Ehman},
abstract={Prostate cancer(PCa) is one of the leading causes of cancer-related deaths in North American men. Nodal metastases occur in 3-42\% of men with clinically localized prostate cancer and the presence of nodal metastases has a strong negative impact on survival. Lymph node staging plays an important role in planning initial management in nonmetastatic PCa. Early detection and resection are important for staging and for the prognosis. We evaluated the diagnostic performance of MR elastography (MRE) in patients with PCa. Results from 33 patients with PCa show that MRE at both of 60Hz and 90Hz has the potential to be a useful technique for predicting PCa lymph node metastases and to establish prognosis and treatment planning.}
}
@inproceedings{ISMRM2018_4382,
annote={ISMRM2018_4382},
pages={4382},
file={ISMRM2018_4382.pdf:ISMRM2018_4382.pdf:PDF},
title={Improvement of prostate cancer detection combining a computer aided diagnosis system to {TRUS}-{MRI} targeted biopsy.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4382.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Martina Pecoraro and Riccardo Campa and Giovanni Barchetti and Isabella Ceravolo and Vincenzo Salvo and Elena Lucia Indino and Maurizio Del Monte and Carlo Catalano and Valeria Panebianco},
abstract={To validate the role of mpMRI combined to CAD system, to increase prostate cancer detection rate using TRUS-MRI guided biopsy. 167 individuals, with elevated PSA level and no previous positive biopsy were enrolled and 63 underwent targeted biopsy. Two radiologists evaluated the exams adopting PIRADSv2 and CAD system. Radiologists’ evaluation proved better diagnostic performance compared to CAD. The highest detection rate for clinically significant cancer was obtained biopsying “target into target” lesions. CAD system proved to be useful in pinpointing the neoplastic area within MRI lesions, representing a valuable tool in identifying biopsy targets to improve CDR.}
}
@inproceedings{ISMRM2018_4383,
annote={ISMRM2018_4383},
pages={4383},
file={ISMRM2018_4383.pdf:ISMRM2018_4383.pdf:PDF},
title={Intravoxel Incoherent Motion Diffusion Weighted Imaging of Prostate Cancer},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4383.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Lei Qin and Daniel I Glazer and Pelin Aksit Ciris and Andriy Fedorov and Thiele Kobus and Fiona M Fennessy and Stephan E Maier and Robert Mulkern},
abstract={Intravoxel Incoherent Motion (IVIM) DWI was acquired with 13 b-values, ranging from 0 to 250 s/mm
2. With such low b-values, a short TE results in a better signal-to-noise ratio. Monoexponential fitting was performed to obtain ADC and biexponential fitting was performed to obtain diffusion D, perfusion fraction f and perfusion related pseudo-diffusion coefficient D*. In a prostate cancer (PCa) patient cohort, we only found a significant difference between normal and tumor tissue for D, which was absent in ADC, f and D*. This suggests that IVIM biexponential analysis can help remove perfusion component from diffusion, leading to a more accurate measurement in diffusion coefficient.}
}
@inproceedings{ISMRM2018_4384,
annote={ISMRM2018_4384},
pages={4384},
file={ISMRM2018_4384.pdf:ISMRM2018_4384.pdf:PDF},
title={3T Multiparametric {MRI} based detection of Prostate Cancer: features of detected and missed tumors base on {PIRADS} v2 in 429 patients- using whole mount histopathology reference},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4384.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Amirhossein Mohammadian Bajgiran and Sohrab Afshari Mirak and Ely Felker and Preeti Ahuja and Cleo Maehara and William Hsu and David Lu and Robert Reiter and Anthony Sisk and Steve Raman},
abstract={We evaluated the performance of the 3 Tesla multiparametric MRI (mp-MRI) for detection of prostate cancer (PCa) based on Prostate Imaging Reporting and Data System (PI-RADS) Version 2 in 429 patients with 874 lesions. The overall and index tumor detection rate of 3T mp-MRI was 49.3\% and 77.9\% respectively. The tumor detection rate based on PIRADSv2 increased by size, grade, stage, solitariness and smaller prostate volume. Most missed lesions were small and low grade although a small proportion of large and high gradelesions were not detected.}
}
@inproceedings{ISMRM2018_4385,
annote={ISMRM2018_4385},
pages={4385},
file={ISMRM2018_4385.pdf:ISMRM2018_4385.pdf:PDF},
title={Clinical usage and impact of predictive models of prostate cancer on multiparametric {MRI}: a single-observer exploratory evaluation},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4385.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ethan Leng and Benjamin Spilseth and Gregory J. Metzger},
abstract={A single-observer, experiential study was conducted to understand how predictive models of prostate cancer on multiparametric MRI can be used clinically and to determine whether such models have the potential to improve observer performance. A radiologist experienced in prostate MRI was asked to interpret mpMRIs for 34 patients before and after viewing model-generated predictive maps. Results show that the radiologist generally had low confidence in the accuracy of the predictive maps. However, his performance was significantly improved in the cases where he judged the predictive maps to be helpful. A multi-reader iteration of the study is planned.}
}
@inproceedings{ISMRM2018_4386,
annote={ISMRM2018_4386},
pages={4386},
file={ISMRM2018_4386.pdf:ISMRM2018_4386.pdf:PDF},
title={Estimation of prostate cancer distribution on pathology slides via image analysis of {IHC}-stained slides.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4386.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ethan Leng and Jonathan C. Hendriksen and Jin Jin and Stephen C. Schmechel and Gregory J. Metzger},
abstract={For the development of CAD systems of prostate cancer, manual annotation of cancer by experienced pathologists is the gold standard for establishing the ground truth. However, the process is tedious and has finite precision. Here, we describe a framework that uses quantitative analysis of IHC-stained slides to derive parameters, which in turn are used by a trained predictive model to estimate the spatial distribution of malignant epithelium. Thresholding of the results provides a reasonable map of cancer that is comparable to manual annotation.}
}
@inproceedings{ISMRM2018_4387,
annote={ISMRM2018_4387},
pages={4387},
file={ISMRM2018_4387.pdf:ISMRM2018_4387.pdf:PDF},
title={The RadPath Surfer: A Radiologic-Pathologic tool for visualizing prostate cancer histology},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4387.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Sean D McGarry and Sarah L Hurrell and Kenneth Jacobsohn and Kenneth A Iczkowski and Michael Griffin and Petar Duvnjak and Andrew Nencka and Mark Hohenwalter and Peter LaViolette},
abstract={Prostate cancer is clinically defined by the Gleason Score (GS), based on the pattern of cells and glands. While imaging is useful for localizing prostate cancer, clinical diagnosis is based only on pathology; as such, tools which combine clinical imaging and pathology are highly useful as training tools. This study combines expert annotated histology aligned with clinical imaging to provide a visualization tool, allowing the user to select a region on the MRI and view the underlying pathology and Gleason annotation.}
}
@inproceedings{ISMRM2018_4388,
annote={ISMRM2018_4388},
pages={4388},
file={ISMRM2018_4388.pdf:ISMRM2018_4388.pdf:PDF},
title={Diagnostic performance of qualitative and quantitative 3T {DCE}-{MRI} parameters of prostate cancer lesions in transition and peripheral zone stratified by pathology Gleason score and {PI}-{RADS}v2 score},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4388.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Sohrab Afshari Mirak and Kyung Hyun Sung and Amirhossein Mohammadian Bajgiran and Nazanin Hajarol Asvadi and Ely R Felker and Preeti Ahuja and Anthony Sisk and Robert Reiter and Steven Raman},
abstract={We investigated the diagnostic performance of qualitative and quantitative parameters of dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) of prostate cancer (PCa) in 238 patients with 303 lesions located in transition (TZ) and peripheral zone (PZ) stratified by pathology Gleason score (GS) and PI-RADSv2 score with whole mount histopathology validation. There was a significant difference in qualitative and quantitative values between low and high-grade tumors and PI-RADSv2 scores in PZ PCa lesions. However, for tumors located in TZ, only DCE curve type was significantly different between low and high-grade PCa.}
}
@inproceedings{ISMRM2018_4389,
annote={ISMRM2018_4389},
pages={4389},
file={ISMRM2018_4389.pdf:ISMRM2018_4389.pdf:PDF},
title={Diffusion-weighted Imaging and Dynamic Contrast-enhanced Imaging Distinguish Inflammation from Low Grade Cancer and Normal Tissue in the Peripheral Zone of the Prostate},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4389.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Natalie Korn and Olga Starobinets and Jeffry Simko and John Kurhanewicz and Susan M Noworolski},
abstract={Inflammation can complicate the ability to distinguish normal tissue from cancer in the peripheral zone of the prostate. In this work, we show that a multiparametric MRI including dynamic contrast-enhanced imaging (DCE) and diffusion-weighted imaging can distinguish inflammation in the peripheral zone of the prostate from both low-grade prostate cancer and normal tissue. A depth-restricted decision tree built on the apparent diffusion coefficient (ADC) and maximal wash-in slope on DCE correctly classified 79.6\% of regions of normal tissue, inflammation and low-grade cancer in the peripheral zone of the prostate based on pathologist-detailed regions on whole-mount resected glands.
}
}
@inproceedings{ISMRM2018_4390,
annote={ISMRM2018_4390},
pages={4390},
file={ISMRM2018_4390.pdf:ISMRM2018_4390.pdf:PDF},
title={Exploring the performance of high density detector coil arrays at 10.5 Tesla},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4390.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Riccardo Lattanzi and Manushka Vaidya and Daniel K Sodickson and Kamil Uğurbil and Gregor Adriany},
abstract={We used a uniform sphere to model the human head and investigated the performance of receive loop arrays for brain imaging at 10.5T to evaluate the advantage of using a large number of detectors, both alone and in combination with high-permittivity materials (HPM). We show that the ultimate intrinsic signal-to-noise ratio in the central region could be approached with a relative small number of loop coils, whereas more elements are needed to maximize SNR near the surface and to achieve large acceleration factors. Superficial SNR at 10.5T could be considerably enhanced using HPM fairly easy to achieve in practice.}
}
@inproceedings{ISMRM2018_4391,
annote={ISMRM2018_4391},
pages={4391},
file={ISMRM2018_4391.pdf:ISMRM2018_4391.pdf:PDF},
title={Virtual Population Based Correlations between B1+, Whole-Body and Local {SAR}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4391.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Manuel Murbach and Earl Zastrow and Niels Kuster},
abstract={Knowledge about the relationship between B1+rms and SAR is beneficial for the MRI RF safety community, consisting of academic investigators, MRI and implant vendors and regulatory bodies. While implant manufacturers have already started to shift device-labelling form SAR to B1+rms, there is not yet available a systematic evaluation of their relationship. In this study, we aim to close this gap by presenting a systematic methodology for numerical estimations of an entire exposure-scenario matrix, including various human anatomical models, imaging positions and MRI body-coil geometries.}
}
@inproceedings{ISMRM2018_4392,
annote={ISMRM2018_4392},
pages={4392},
file={ISMRM2018_4392.pdf:ISMRM2018_4392.pdf:PDF},
title={About the Ideal Receive Array for Human Head {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4392.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Andreas Pfrommer and Anke Henning},
abstract={For the first time, we present a systematic framework to assess the intrinsic SNR performance of loop-only and dipole-only receive arrays in a realistic human head model. Thereby, we distribute generic current patterns on a helmet-like and a cylindrical coil holder. These current patterns form a basis set for any kind of receive element one could place on the holder. We demonstrate how to design an ideal receive array for human head applications by using complementary current patterns.}
}
@inproceedings{ISMRM2018_4393,
annote={ISMRM2018_4393},
pages={4393},
file={ISMRM2018_4393.pdf:ISMRM2018_4393.pdf:PDF},
title={Comparison of Electric and B1+ Fields for Heterogeneous and Homogeneous Anthropomorphic Phantoms and Anatomical Models: Numerical Simulations and Experimental Findings},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4393.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Sossena Wood and Tales Santini and Narayanan Krishnamurthy and Tiago Martins and Tamer S Ibrahim},
abstract={While numerical phantoms and detailed human tissue models have been available for some time in MR
1-5, the development of experimental phantoms has yet to fully evolve. The growth of rapid prototyping and mimicry of tissues through tissue engineering is making it more possible for realistic electromagnetic phantoms that mimic human anatomy to be available to MR researchers and their collaborators. Wood et al.
6 fabricated a realistic head model (shown in Figure 1A) that can be used for a wide-variety of MR purposes and builds on the work of Gradel et al.7. However, the argument can still be made as to how beneficial it is to have a heterogeneous anthropomorphic phantom in place of a homogeneous anthropomorphic phantom. We hypothesize that the differences will be greatest in the electric field intensities and distribution as opposed to the B1+ field. In this work, we perform numerical studies and experimental 7T measurements that highlight the differences in the electric field and magnetic field of an anthropomorphic phantom (computer model as well as 3D printed) filled with homogeneous and heterogeneous media in comparison to a 10-tissue segmented head model. The phantom uses a resin plastic material that approximates the electromagnetic constitutive properties of a combination fat, boneand skin.}
}
@inproceedings{ISMRM2018_4394,
annote={ISMRM2018_4394},
pages={4394},
file={ISMRM2018_4394.pdf:ISMRM2018_4394.pdf:PDF},
title={Platform for Validating pTx {RF} Coil Simulations Using Proton Resonance Frequency Shift {MR} Thermometry},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4394.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Hongbae Jeong and Matthew Restivo and Peter Jezzard and Aaron Hess},
abstract={We propose a workflow to validate parallel transmission (pTx) RF heating patterns using Proton-Resonance Frequency shift (PRF)-based MR thermometry. An agar+polyethylene powder cylindrical phantom, with similar dielectric properties to the human brain at 297.2 MHz, was designed to assess an 8-channel dipole array. RF heating was evaluated and compared between PRF-based MR thermometry, fibre optic probe measurement and thermal simulation. The PRF reconstruction procedure was optimized to reduce artefacts. Given the importance of RF safety in pTx applications, this method enables accurate validation of RF heating simulations with minimal additional hardware requirements.}
}
@inproceedings{ISMRM2018_4395,
annote={ISMRM2018_4395},
pages={4395},
file={ISMRM2018_4395.pdf:ISMRM2018_4395.pdf:PDF},
title={An improved 32-channel loop-dipole transceiver array design for body imaging at 7.0 Tesla: Simulation study},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4395.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={M. Arcan Erturk and Xiaoping Wu and Gregor Adriany and Russell L Lagore and Kamil Ugurbil and Gregory J Metzger},
abstract={An improved 32-channel transmit/receive (transceiver) body array (32LD) is designed by combining eight fractionated dipole elements with 24 loops, 3 each stacked lengthwise above each dipole. Performance of the 32LD is compared against a 16-channel loop-dipole (16LD) array through numerical modeling/simulations around the pelvis and torso of a male human model. The 32LD has ~10\% SNR gain in deep centrally located tissues (prostate), >20\% gain in medium-depth imaging targets (kidneys) and >30\% near the surface. The 32LD has improved field-uniformity, higher transmit efficiency, comparable SAR to 16LD with phase-only RF shimming; and improved excitation fidelity with multi-band parallel transmit pulses.}
}
@inproceedings{ISMRM2018_4396,
annote={ISMRM2018_4396},
pages={4396},
file={ISMRM2018_4396.pdf:ISMRM2018_4396.pdf:PDF},
title={Exploring how modeling the head as a multi-layered vs. uniform sphere affects ultimate intrinsic signal-to-noise ratio and coil performance prediction},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4396.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jonghyun Bae and Manushka V Vaidya and Riccardo Lattanzi},
abstract={We investigated differences in ultimate intrinsic SNR and simulated SNR for finite coils when modeling the human head as a single-layer uniform sphere with average brain electrical properties vs. a three-layer sphere that accounts also for skull and skin tissue. We show that the uniform sphere provides a good approximation of the head for simulations up to 3T, but becomes less accurate at ultra-high field strengths.}
}
@inproceedings{ISMRM2018_4397,
annote={ISMRM2018_4397},
pages={4397},
file={ISMRM2018_4397.pdf:ISMRM2018_4397.pdf:PDF},
title={Improving breast imaging B1+ homogeneity with B1 shimming at 1.5T: a modeling study},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4397.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Xin Chen and Xin Li and Danielle Kara and Mingdong Fan and Joseph Rispoli and Michael Steckner and Robert Brown},
abstract={B1+ inhomogeneity is a challenge for breast imaging and B1 shimming is standard for all 3T clinical MRI applications. While B1+ homogeneity is typically better at 1.5T than 3T due to reduced wavelength effects, breast image quality is still challenged by B1+ inhomogeneity at 1.5T. This work shows B1 shimming can significantly improve B1+ homogeneity for breast imaging at 1.5T as compared to conventional quadrature drive.}
}
@inproceedings{ISMRM2018_4398,
annote={ISMRM2018_4398},
pages={4398},
file={ISMRM2018_4398.pdf:ISMRM2018_4398.pdf:PDF},
title={Feasibility exploration of constructing volume {RF} coil with coupled dipole antennas at 9.4T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4398.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Shasha Yue and Chao Luo and Nan Li and Jo Lee and Qiaoyan Chen and Ye Li and Xiaoliang Zhang},
abstract={Dipole antenna, a simple resonator structure, has demonstrated a unique capability of achieving high resonant frequency and utility in MR imaging. Theoretically, this simple resonator structure could be advantageous for building non-array volume RF coil design for ultrahigh field MR imaging applications. In this work, we explore the feasibility of using dipole antenna as resonant element to design non-array volume coils for the ultrahigh field 9.4T MR imaging. The results show that the dipole antennas have sufficient coupling among the resonator elements to create multi-mode resonances and form uniform B1 field distribution within the volume coil at 400 MHz.}
}
@inproceedings{ISMRM2018_4399,
annote={ISMRM2018_4399},
pages={4399},
file={ISMRM2018_4399.pdf:ISMRM2018_4399.pdf:PDF},
title={Simulation study about New {RF} loop coil with homogenous 7T B1 field},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4399.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Seunghoon Ha and Adam Morris and Jonathan Nass},
abstract={A loop coil design with homogenous B1 field and competitive sensitivity for 7T MRI was presented. The proposed coil was able to align on ROI unlike the asymmetric segmented loop coil design. The calculated B
1 field uniformity and coil sensitivity of the proposed coil was superior to the asymmetric segmented loop coil as well as the loop coil with symmetrically distributed capacitors. The eight channels volume shaped loop array constructed by the proposed design loops was simulated. The proposed design will potentially help the construction of larger size loop arrays to cover more imaging volume at 7T and higher.}
}
@inproceedings{ISMRM2018_4400,
annote={ISMRM2018_4400},
pages={4400},
file={ISMRM2018_4400.pdf:ISMRM2018_4400.pdf:PDF},
title={Design and simulation of dual-band dipole antenna for 1H/31P at 9.4T {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4400.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Suk-Min Hong and Chang-Hoon Choi and Jörg Felder and N. Jon Shah},
abstract={The resonance frequency of a dipole antenna is defined by its length (λ/2). The use of LC traps at specific locations within the dipole antenna generates additional resonances. We designed a dual-band dipole antenna tuned to 400 MHz for
1H and 160 MHz for
31P with the aid of an LC trap. The length of the dipole antenna was shortened to 32 cm by introducing end meanders and this concept was also expanded to form a 4-channel array. The performance of the dual-band dipole antenna was simulated and the feasibility of using it as an antenna array is demonstrated.}
}
@inproceedings{ISMRM2018_4401,
annote={ISMRM2018_4401},
pages={4401},
file={ISMRM2018_4401.pdf:ISMRM2018_4401.pdf:PDF},
title={Fast Optimization Method for {RF} Coil Array Geometry in a Post-Processing Step},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4401.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jan Paska and Amparo Ruiz and Jose Raya},
abstract={In this work we propose a novel single-run simulation method for RF coil design spanning enough of the design space to provide a clear intuition on optimal coil design, offer a benchmark SNR and predict coil losses and coupling. It is based on the combination of conductors and sources to emulate coil arrays in a post-processing step. We demonstrated our method's potential for the optimization of an RF coil array for imaging of the rat limb at 7T. We validated our method using electromagnetic (EM) field simulations.}
}
@inproceedings{ISMRM2018_4402,
annote={ISMRM2018_4402},
pages={4402},
file={ISMRM2018_4402.pdf:ISMRM2018_4402.pdf:PDF},
title={Validation of numerical simulation of susceptibility artifact and the consequences for artifact size calculation of the current {ASTM} standard F2119},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4402.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Tobias Spronk and Archana Chinnaiyan and Jakob Kreutner and Gregor Schaefers},
abstract={The ASTM standard F2119 provides evaluation methods for the artifacts of medical implants in a well-defined test environment. In our work we had validated a numerical simulation of MR susceptibility artifacts according to this standard. Based on this simulation, the calculation methods of the artifact size in the ASTM standard were evaluated to show the limitation of the current methods.}
}
@inproceedings{ISMRM2018_4403,
annote={ISMRM2018_4403},
pages={4403},
file={ISMRM2018_4403.pdf:ISMRM2018_4403.pdf:PDF},
title={Simplifying the Numerical Human Model with k-means Clustering Method},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4403.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Kyoko Fujimoto and Leonardo M Angelone and Sunder S Rajan and Maria Ida Iacono},
abstract={Currently, the safety assessment of radio-frequency (RF) heating in computational modeling is limited by the available numerical models which are not patient-specific although RF-induced heating depends on the physical characteristics of the patient. The numerical model generation is difficult due to the highly time-consuming segmentation process. Therefore, having fewer types of segmented structures simplifies the generation of numerical models. In this study, we used the k-means clustering method to reduce the number of dielectric properties of an existing numerical model and investigated the resulting difference in SAR with respect to the number of clusters.}
}
@inproceedings{ISMRM2018_4404,
annote={ISMRM2018_4404},
pages={4404},
file={ISMRM2018_4404.pdf:ISMRM2018_4404.pdf:PDF},
title={Accelerating the Co-Simulation Method for Fast Design of Transmit Array Coils: An Example Study on a Degenerate Birdcage Coil},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4404.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Alireza Sadeghi-Tarakameh and Ehsan Kazemivalipour and Taner Demir and Umut Gundogdu and Ergin Atalar},
abstract={The co-simulation method suffers local minima during the design of a transmit array coils. In this study, our purpose is to utilize an equivalent circuit model of the coil and analytical calculations to provide a proper initial guess for co-simulation method. For the proof of concept, we designed and constructed an eight-channel head-degenerate birdcage coil (DBC) for a 3T scanner using this method which decreased the optimization time by more than 6000 fold.}
}
@inproceedings{ISMRM2018_4405,
annote={ISMRM2018_4405},
pages={4405},
file={ISMRM2018_4405.pdf:ISMRM2018_4405.pdf:PDF},
title={{SNR} Evaluation for a high-permittivity dielectric helmet-shaped coil former for a 28 channel receive array},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4405.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Giuseppe Carluccio and Gillian Haemer and Manushka Vaidya and Sebastian Rupprecht and Qing Yang and Christopher Michael Collins},
abstract={The performance of a high-permittivity helmet-shaped former is evaluated when used to improve the SNR in the head for a 28-channel receive array coil. Through simulations, it was found that the use of the helmet can dramatically increase the SNR in the head, up to more than 3 times the original value in some locations of the head and about 50\% increase overall in the brain.}
}
@inproceedings{ISMRM2018_4406,
annote={ISMRM2018_4406},
pages={4406},
file={ISMRM2018_4406.pdf:ISMRM2018_4406.pdf:PDF},
title={New optimization strategies for {RF} shimming at {UHF} {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4406.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Tales Santini and Sossena Wood and Narayanan Krishnamurthy and Yutong Zhang and Nadim Farhat and Neilesh Vinjamuri and Minseok Koo and Howard Aizenstein and Tamer S. Ibrahim},
abstract={This work proposes four optimization strategies for the RF shimming in UHF MRI. The results show a minimum coefficient of variation of B1+ field distribution over the human head = 23\%/17\%/14\% for the 4chTEM, 16chTTT and 64chTTT respectively. For the maximum over minimum evaluation criteria of the B1+ field distribution, the best values were 6.70/2.92/2.23 for 4chTEM/16chTTT/64chTTT coils. For a fixed mean B1+ field over the human head, the best average SAR values were 2.09/1.28W/kg for the 4chTEM/16chTTT coils respectively. These strategies can be applied to any RF transmit array system, but are most beneficial for highly parallel systems.}
}
@inproceedings{ISMRM2018_4407,
annote={ISMRM2018_4407},
pages={4407},
file={ISMRM2018_4407.pdf:ISMRM2018_4407.pdf:PDF},
title={Evaluation of {RF} Shielding Effectiveness by Method of Moments},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4407.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yihe Hua and Teck Beng Desmond Yeo and Thomas Foo and Dominic Graziani and Justin Ricci and Joseph Piel and Keith Park},
abstract={In MRI system, RF shielding is designed to isolate the RF coil from outside conductive objects. Usually simulation is done with only RF coil and RF shielding being included and the impact from outside objects could be qualitatively estimated by limiting the fringe field of the RF coil to a certain level. In this work, the impact from gradient coil to the RF coil can be examined quantitatively rather than qualitatively via the S-parameters of the RF coil being studied with Method of Moments. which is very useful for the RF shielding design.}
}
@inproceedings{ISMRM2018_4408,
annote={ISMRM2018_4408},
pages={4408},
file={ISMRM2018_4408.pdf:ISMRM2018_4408.pdf:PDF},
title={Development of an Asymmetrical Birdcage Design towards Homogeneous Volume Excitation for Hyperpolarized Xenon-129 Lung Imaging at 3T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4408.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Wolfgang Loew and Christopher Ireland and Zackary Cleveland and Hui Wang and Peter van der Meulen and Randy Giaquinto and Ronald Pratt and Jason Woods and Charles Dumoulin},
abstract={Hyperpolarized
129Xe imaging is increasingly viewed as a viable tool for assessing lung structure and function.
129Xe MRI requires that large flip angle and frequency selective RF pulses be applied homogeneously across the entire thorax. The transmit performance of three common multi-nuclear whole-body birdcage designs was assessed under a loaded condition at different locations inside the RF shield with electromagnetic field simulations. The acquired data was used to develop a novel, optimized birdcage design for which the transmit performance was analyzed and compared to the three common designs.}
}
@inproceedings{ISMRM2018_4409,
annote={ISMRM2018_4409},
pages={4409},
file={ISMRM2018_4409.pdf:ISMRM2018_4409.pdf:PDF},
title={Computer-aided design and simulation of a double-nuclear parallel transmit {RF} coil array for proton {MRI} and carbon-13 {MRS} of human extremities at 7T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4409.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Omar Rutledge and Riccardo Stara and Brian Rutt},
abstract={
13C MR spectroscopy can offer important metabolic information in the musculoskeletal system without the use of ionizing radiation. In this work, we design and simulate a novel double-nuclear pTx RF coil array (8-channel per frequency) with ICE decoupling coils for proton MRI and
13C MRS of human extremities. Coupling was compared between the RF coil array with and without ICE elements demonstrating the significant decoupling effect of the ICE coils. Calculated B
1+ field maps for both the proton MTLs and the
13C loops with ICE elements show sufficient transverse magnetization for MRI and MRS applications. Through the use of switch-tuned ICE decoupling elements, we have demonstrated the feasibility of dual-frequency pTx arrays for
1H imaging and
13C spectroscopy of human extremities at 7T.}
}
@inproceedings{ISMRM2018_4410,
annote={ISMRM2018_4410},
pages={4410},
file={ISMRM2018_4410.pdf:ISMRM2018_4410.pdf:PDF},
title={High Density Volume Array Strategies for {SNR} and Parallel {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4410.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Scott B King and Zhiyong Zhai},
abstract={Most receive array coils are made of many various shapes of loop coils with different arrangements. In practice, the final goal for a good performance array coil is to find a combination of these loop coils such that improved optimal signal-to-noise ratio (SNR)1-3 and reduced parallel MRI g-factor3 can be achieved in the same time. Here we study four different loop coil arrangements for a head array coil. The simulation results shed some light on optimal loop arrangements and performance expectations.}
}
@inproceedings{ISMRM2018_4411,
annote={ISMRM2018_4411},
pages={4411},
file={ISMRM2018_4411.pdf:ISMRM2018_4411.pdf:PDF},
title={Combined {EM} simulations and measurements of birdcage coil B1+ for designing a 3T multichannel {TMS} /{MRI} head coil array},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4411.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Lucia I Navarro de Lara and Laleh Golestani Rad and Sergey Makarov and Jason P Stockmann and Lawrence L Wald and Thomas Witzel and Aapo Nummenmaa},
abstract={The multichannel TMS approach enables steering the stimulation “hot spot” electronically making the execution of concurrent TMS and fMRI experiments potentially more flexible. An integrated multichannel TMS/MRI system is currently under development and here we investigate how TMS coils influences the B
1+ field of a birdcage coil. We compare detailed electromagnetic simulations with empirical data using a single three-axis TMS coil element as well as generate simulated data for 4x4 TMS coil array. Both simulations and empirical results indicate that an array of TMS coils should not distort the B
1+ significantly at distances bigger than 2cm from the coil.}
}
@inproceedings{ISMRM2018_4412,
annote={ISMRM2018_4412},
pages={4412},
file={ISMRM2018_4412.pdf:ISMRM2018_4412.pdf:PDF},
title={Reverse Engineering of a 7T 16-Channel Dual-Row Transmit Array Coil},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4412.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Mikhail Kozlov and Nikolaus Weiskopf and Harald E. Möller and Gunamony Shajan},
abstract={We developed a reverse engineering numerical workflow that yielded a good match between measured and simulated scattering parameters of an inductively decoupled non-overlapped dual-row transmit array for MRI at 7T. We evaluated and compared the performance of different tuning conditions resulted in similar scattering parameters. For the circular polarization mode under-coupled, over-coupled, or mixed tuning conditions resulted in up to 65\% variation of different coil losses but small variation of transmit efficiency. For comparisons of array transmit performance, consideration of array-internal losses as well as reflected and radiated power is very important, because their sum can be as high as 71\% of the total transmit power.}
}
@inproceedings{ISMRM2018_4413,
annote={ISMRM2018_4413},
pages={4413},
file={ISMRM2018_4413.pdf:ISMRM2018_4413.pdf:PDF},
title={{ASIC} Model of {SENSE} to Accelerate {MR} Image Reconstruction},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4413.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Sohaib A Qazi and Faisal Siddiqui and J Jacob Wikner and Hammad Omer},
abstract={In Parallel MRI (pMRI), imaging process is accelerated by acquiring less data using multiple receiver coils and offline reconstruction algorithms (e.g. SENSitivity Encoding (SENSE)) are applied to reconstruct fully sampled data. We present a synthesizable high-description language (HDL) model of SENSE algorithm where the reconstruction can be performed within signal processing chain of MRI scanner. The proposed architecture is tested using simulated human brain data with 8 channel receiver coils and quality of reconstructed images is analyzed using artifact power. The results show that the proposed reconstruction model achieves 0.014 artifact power and is 700 times faster than the CPU based SENSE reconstruction.
}
}
@inproceedings{ISMRM2018_4414,
annote={ISMRM2018_4414},
pages={4414},
file={ISMRM2018_4414.pdf:ISMRM2018_4414.pdf:PDF},
title={Holographic Computing for {MRI}-based Visualization and Interactive Planning of Prostate Interventions},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4414.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Cristina M. Mojica and Nikhil V. Navkar and Shidin Balakrishnan and Julien Abinahed and Walid El Ansari and Khalid Al-Rumaihi and Adham Darweesh and Abdulla Al-Ansari and Mohamed Gharib and Mansour Karkoub and Nikolaos V. Tsekos},
abstract={A platform is presented for holographic visualization and planning of image-guided prostate interventions. Its pipeline includes modules dedicated for MRI segmentation, structure rendering, trajectory planning for biopsy or brachytherapy needles and the spatial co-registration of the outcomes of these modules for augmented reality holographic rendering. The interface was implemented on a HoloLens smart-glasses enabling gesture and voice activation for interactive selection of the input parameters of any module. The work is motivated by the potential of holographic augmented reality to offer true 3D appreciation of the morphology of the area of the procedure and interactive planning of access trajectories.}
}
@inproceedings{ISMRM2018_4415,
annote={ISMRM2018_4415},
pages={4415},
file={ISMRM2018_4415.pdf:ISMRM2018_4415.pdf:PDF},
title={Comparison of {MRI} subsystem performances for two models of {MRI}-guided radiotherapy: {MRI}-Cobalt-60 versus {MRI}-Linac},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4415.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Olga L Green and James Flock and Rajiv Lotey and Austen N Curcuru and Sasa Mutic and H Michael Gach},
abstract={The era of MRI-guided radiation therapy (MR-IGRT) began in January 2014 when the first patient was treated with
60Co under real-time MRI guidance. In 2017, the first FDA-approved MRI-Linac began treating patients. Both systems incorporate a double donut magnet design with a 28 cm gap for the radiation beam. A rotating gantry carries either three shielded
60Co heads or a 6 MV Linac with magnetic and RF shielding. In this study, we compare the MRI subsystem performance between the two systems.}
}
@inproceedings{ISMRM2018_4416,
annote={ISMRM2018_4416},
pages={4416},
file={ISMRM2018_4416.pdf:ISMRM2018_4416.pdf:PDF},
title={Simultaneous {MR} and Ultrasound Acquisition for Image Guided Radiation Therapy using an {MR}-compatible, Hands-free, Electronically Steerable Ultrasound Transducer},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4416.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Thomas Foo and Warren Lee and David Mills and David Shoudy and Heather Chan and Aqsa Patel and James Sabatini and Timothy Fiorillo and Eric Fiveland and Lowell Scott Smith and Bo Wang and Jhimli Mitra and Shourya Sarcar and Alan McMillan and James Holmes and Wes Culberson and Michael Bassetti and Charles Matrosic and Andrew Shepard and Bryan Bednarz},
abstract={A new approach is developed for intrafractional motion management in radiation therapy (RT) that accounts for respiratory-induced motion using a prior simultaneous MR-ultrasound acquisition to provide “virtual” real-time MR image guidance during the RT procedure. This proposed solution first acquires simultaneous MR and ultrasound to link MR images to different respiratory states that are determined from 4D ultrasound images. During the RT procedure, the hands-free 4D ultrasound determines the respiratory state from displacement of endogenous fiducial markers. MR images corresponding to each respiratory state are displayed to provide an indication of the tumor target relative to the radiation beam.}
}
@inproceedings{ISMRM2018_4417,
annote={ISMRM2018_4417},
pages={4417},
file={ISMRM2018_4417.pdf:ISMRM2018_4417.pdf:PDF},
title={A Novel Hybrid Method for Gradient Nonlinearity ({GNL}) Correction for {MRI}- Linac system},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4417.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Shanshan shan and Mingyan Li and Yaohui Wang and Fangfang Tang and Deming Wang and Haiwei Chen and Ewald Weber and Rafael Franco and Craig Freakley and Feng Liu and Stuart Crozier},
abstract={MRI-guided radiotherapy requires precise image geometric information to target a tumour without unnecessary radiation on healthy surrounding tissue. Due to the imperfections in the gradient system and engineering limitations, however, gradient non-linearity (GNL) inevitably occurs and causes image distortions if not properly accounted for. Here we propose a novel method to estimate the gradient field using stream function methods with a grid phantom. The estimated gradient field was then used for GNL distortion correction and image reconstruction. Initial simulations demonstrated that the image geometric distortion in a combined MRI and linear accelerator (MRI-Linac) system was effectively improved by the proposed method.}
}
@inproceedings{ISMRM2018_4418,
annote={ISMRM2018_4418},
pages={4418},
file={ISMRM2018_4418.pdf:ISMRM2018_4418.pdf:PDF},
title={High Resolution Tomographic Imaging with a 6.3 T/m Field Free Line Magnetic Particle Imager},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4418.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Elaine Yu and Bo Zheng and Zhi Wei Tay and Paul Keselman and Xinyi Y Zhou and Ryan Orendorff and Daniel W Hensley and R Matthew Ferguson and Amit P Khandhar and Scott J Kemp and Kannan M Krishnan and Patrick Goodwill and Steven Conolly},
abstract={Magnetic Particle Imaging (MPI) is a novel, high-contrast and quantitative imaging modality that directly detects superparamagnetic iron oxide nanoparticle (SPIO) tracers. In MPI, the imaging sensitive region is a field free region produced by a strong gradient selection field. There are two imaging formats in MPI: Field Free Point (FFP) and Field Free Line (FFL). The spatial resolution of our previous FFL imager was limited by the strength of the FFL gradient (2.35 T/m). Here we describe the hardware development of a high resolution 6.3 T/m FFL MPI system using water-cooled electromagnets and a laminated iron-core.}
}
@inproceedings{ISMRM2018_4419,
annote={ISMRM2018_4419},
pages={4419},
file={ISMRM2018_4419.pdf:ISMRM2018_4419.pdf:PDF},
title={A 3T Head Scanner Designing Stage: the {HTS} magnet and the 200mT/m Hyper-Vision Gradient Coil.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4419.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Hector Sanchez Lopez and Hidenao FUKUYAMA},
abstract={This work presents the design stage of a 3T MRI head scanner aimed to register temporal physiological events in the scale below 1 sec while imaging brain structures below 0.5 mm of resolution. The hyper-vision gradient coil concept is capable to produce 200 mT/m and nearly 1900 T/m/s using a high end amplifier. The 3D folded coil exhibits shoulder cut of an aperture of 250 mm and a DSV of 250mmx210mm while keeping resistance, eddy currents, force and inductive decoupling with the HTS magnet under control. Details and characteristics of the coil and magnet are presented in this work.}
}
@inproceedings{ISMRM2018_4420,
annote={ISMRM2018_4420},
pages={4420},
file={ISMRM2018_4420.pdf:ISMRM2018_4420.pdf:PDF},
title={Laplacian-Inspired Design of a Highly-Homogeneous, {RF} Shielded Magnet for Low-Field {TRASE} {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4420.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={K.M. Smith and C.P. Bidinosti and Scott B. King},
abstract={We present a novel Laplacian design method for a finite length magnet with perfect field homogeneity. It will be used to study TRansmit Array Spatial Encoding (TRASE) MRI at low field. As TRASEdoes not require the application of switched B
0 gradients, we propose to build the magnet on an aluminum housing which acts both as a heat sink and effective low-frequency RF shield.}
}
@inproceedings{ISMRM2018_4421,
annote={ISMRM2018_4421},
pages={4421},
file={ISMRM2018_4421.pdf:ISMRM2018_4421.pdf:PDF},
title={Development of a Gradient and Shim Insert System for Marmoset Imaging at 9.4 T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4421.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Justin Peterson and Ryan Chaddock and Brian Dalrymple and Frank Van Sas and Kyle M Gilbert and Martyn L Klassen and Joseph S Gati and William B Handler and Blaine A Chronik},
abstract={A replacement gradient coil for a 9.4 T preclinical system (31-cm inner diameter magnet) has been designed and is currently under construction. The new gradient and shim system will allow for improved imaging performance on the 9.4 T system and has been developed specifically for marmoset imaging studies. Efficiencies of 1.5 mT/m/A for an ROI of size 8.5 cm at 5\% homogeneity were achieved. A 10-channel shim set (not including first-order gradient shims) is included, with minimized inductive coupling to the gradient axes.}
}
@inproceedings{ISMRM2018_4422,
annote={ISMRM2018_4422},
pages={4422},
file={ISMRM2018_4422.pdf:ISMRM2018_4422.pdf:PDF},
title={A true comparison of B0 shimming with a very high order spherical harmonic based setup and a multi-coil shim array},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4422.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ali Aghaeifar and Paul Chang and Sahar Nassirpour and Martin Eschelbach and Anke Henning and Klaus Scheffler},
abstract={In this work, a true experimental comparison between a very high order spherical harmonic based shim setup and a multi-coil shim array is presented. Each technique has its own cons and pros which are studied through several often-used sequences. All evaluations are performed by shimming of the human brain at 9.4T.}
}
@inproceedings{ISMRM2018_4423,
annote={ISMRM2018_4423},
pages={4423},
file={ISMRM2018_4423.pdf:ISMRM2018_4423.pdf:PDF},
title={Development of a small-car mountable {MRI} system for human extremities using a 0.2 T permanent magnet},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4423.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Katsumasa Tanabe and Mayu Nakagomi and Katsumi Kose and Yoshikazu Okamoto and Sodai Hoshiai and Yasuhiko Terada},
abstract={We developed a new, compact portable MRI system for imaging extremities using a 0.2 T permanent magnet. The system was sufficiently small in size and mountable on a small, standard-sized vehicle. The use of the open-geometry magnet enabled the easy patient positioning within the limited space in the vehicle. We showed that our portable MRI provides clinically relevant images. The portable system might be deployable during sport events or in resource-poor environments access to MRI systems and allow mass screening, early diagnosis and case finding.}
}
@inproceedings{ISMRM2018_4424,
annote={ISMRM2018_4424},
pages={4424},
file={ISMRM2018_4424.pdf:ISMRM2018_4424.pdf:PDF},
title={Switching Impedance Matching and Primary Coil Array Using {RF} {MEMS} switches for a Wireless Power Transfer System},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4424.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Kelly Byron and Fraser Robb and Shreyas Vasanawala and John Pauly and Greig Scott},
abstract={Wireless power transfer (WPT) inside the MRI bore, as part of completely wireless patient coils, should have minimal RF interactions and be a compact system that allows for flexible placement of the coils while maintaining power transfer efficiency. Changes in coil positions can drastically reduce power amplifier efficiency. Here we present a MEMS based auto-tuning approach to compensate for the varying load seen by the power amplifier. An array primary coils also using high-power RF MEMS devices to steer power to a local secondary coil is also demonstrated.}
}
@inproceedings{ISMRM2018_4425,
annote={ISMRM2018_4425},
pages={4425},
file={ISMRM2018_4425.pdf:ISMRM2018_4425.pdf:PDF},
title={Recording Electrophysiological Signals Through {MR} Receiver Coils During Concurrent f{MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4425.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ranajay Mandal and Nishant Babaria and Jiayue Cao and Zhongming Liu},
abstract={Simultaneous recording of fMRI and electrophysiological (EP) signals, e.g. electroencephalography (EEG), electrocorticography (ECoG) and local field potentials (LFP) holds significant potential to evaluate the brain dynamics and its underlying neural circuitry across various spatiotemporal scales. However methodological challenges associated with bio-potential recording within MRI still work as a bottleneck. Here we present a miniaturized, MR-compatible device that can adaptively learn the presence of electromagnetic artifacts and can perform high fidelity EP recording (ECG, LFP, SEP etc.) wirelessly through the MR-receiver coil. The low power device provides a cheap and simple solution for recording various electrophysiological signals during concurrent fMRI.}
}
@inproceedings{ISMRM2018_4426,
annote={ISMRM2018_4426},
pages={4426},
file={ISMRM2018_4426.pdf:ISMRM2018_4426.pdf:PDF},
title={Development of a field camera system for a customized 1.5 T compact {MRI} system},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4426.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yuta Kobayashi and Katsumi Kose and Yasuhiko Terada},
abstract={We developed a field camera system for a 1.5T/280mm superconducting magnet system with unshielded gradient coils. K-space trajectories of a two-dimensional spiral scan were monitored using the field camera system and predicted based on a gradient impulse response function (GIRF). Image reconstruction with these trajectories was effective to recover artifact-free images, even in the presence of hardware imperfections. This result showed the validity of the system.}
}
@inproceedings{ISMRM2018_4427,
annote={ISMRM2018_4427},
pages={4427},
file={ISMRM2018_4427.pdf:ISMRM2018_4427.pdf:PDF},
title={Novel applicator design for {MR} guided {RF} hyperthermia in head and neck cancers: heating performance and {RF} coupling},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4427.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Margarethus Marius Paulides and Tomas Drizdal and Gerard Cornelis Van Rhoon and Desmond Teck Beng Yeo},
abstract={Clinical studies have established the clinical benefit of adjuvant mild hyperthermia in the head and neck, but further improvements are hampered by an inadequate temperature dosimetry. We designed a novel MR compatible hyperthermia applicator ("MRcollar") based on a previously developed antenna concept. Despite the tradeoffs faced when combining heating and imaging, good power focusing ability, i.e. hyperthermia quality and MRI compatibility were demonstrated by simulations and a reduced scale experiment.}
}
@inproceedings{ISMRM2018_4428,
annote={ISMRM2018_4428},
pages={4428},
file={ISMRM2018_4428.pdf:ISMRM2018_4428.pdf:PDF},
title={Output Filter Design for Gradient Amplifier and Shimming Amplifier of {MRI}: an Overview},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4428.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Huijun Yu and Sebastian Littin and Feng Jia and Stefan Kroboth and Maxim Zaitsev},
abstract={Switch-mode gradient amplifiers are widely employed in magnetic resonance imaging systems to drive gradient coils with high current and voltage to provide fast slew rates. The pulse-width modulation control results in unavoidable current ripple and switching noise. Therefore an effective filter is required to attenuate the current ripple and switching noise to avoid image artifacts. Common methods include using single or two stages of LC low pass filter with a disadvantage of bulky size and low ripple attenuation at the switching frequency. Here we present four different filters as alternative designs that introduce a notch mode.}
}
@inproceedings{ISMRM2018_4429,
annote={ISMRM2018_4429},
pages={4429},
file={ISMRM2018_4429.pdf:ISMRM2018_4429.pdf:PDF},
title={Concurrent Excitation and Acquisition for the Ultimate {MRI} Experience: Silent, Implant Friendly, Nearly 100\% Efficient},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4429.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ali Caglar Özen and Burak Akin and Michael Bock},
abstract={Concurrent excitation and acquisition (CEA) allows detecting the MR signal during frequency-swept radio-frequency (RF) excitation without dead times. In our previous work, CEA was realized in a clinical MRI system using a fully automated analog cancellation unit to suppress the unwanted transmit signal leakage during signal reception. In this study, CEA MRI of human head was compared to a 3D UTE sequence; a very fast CEA protocol was demonstrated for 3D radial acquisition of a human ankle; finally rapid passage excitation of the CEA was compared to a hard pulse in terms of SAR.}
}
@inproceedings{ISMRM2018_4430,
annote={ISMRM2018_4430},
pages={4430},
file={ISMRM2018_4430.pdf:ISMRM2018_4430.pdf:PDF},
title={A Signal Loss Compensation Method in an {RF} switch matrix system in Ultra High Field {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4430.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={YunKyoung Ko and Chang-Hoon Choi and N.Jon Shah},
abstract={A crossbar switch matrix can be flexibly connected to any input and output paths via RF switches. However, this type of matrix creates open-stubs in the RF lines. Since the RF wavelength becomes shorter as the magnetic field increases, signal loss due to impedance variations in RF pathways becomes severe, thus degrading image quality. In this study, we propose an advanced compensation method and verify its performance in ultra-high field MRI with single and multi-channel array coils.}
}
@inproceedings{ISMRM2018_4431,
annote={ISMRM2018_4431},
pages={4431},
file={ISMRM2018_4431.pdf:ISMRM2018_4431.pdf:PDF},
title={Advancement in Dynamic Sensitivity Averaging for a Rotating {RF} Coil ({RRFC}) at 9.4T with Compressed Sensing},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4431.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Mingyan Li and Feng Liu and Jin Jin and Ewald Weber and Stuart Crozier},
abstract={We have previously developed a practical imaging scheme for the rotating RF coil (RRFC) in Cartesian trajectories. This scheme employs dynamic sensitivity averaging (DSA) of multiple k-spaces during coil rotation, which eliminates the need of time-consuming, position-dependent sensitivity estimation for image reconstruction of the RRFC. As demonstrated in previous work, two extra complementary profiles are required to achieve efficient DSA, thus the scan duration is potentially extended. To further improve the efficiency of DSA, compressed sensing (CS) is implemented to the image reconstruction of the RRFC.}
}
@inproceedings{ISMRM2018_4432,
annote={ISMRM2018_4432},
pages={4432},
file={ISMRM2018_4432.pdf:ISMRM2018_4432.pdf:PDF},
title={Optimal Bazooka Balun Proportions},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4432.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Victor Taracila and Luke Smith and Ceara Stack and Fraser Robb},
abstract={In MRI, traditional RF coils have cables, which supply the on-coil electronics with power and carry the received signals out from the receive elements to further amplification, digitization and post-processing. The standard technique for blocking currents being induced on the cables uses RF traps, colloquially called bazooka baluns, which represent parallel resonant tanks coupled (magnetically) to the cable. Question: If the volume of the bazooka balun is fixed, what would be its diameter and length so that the impedance of the balun is maximized?}
}
@inproceedings{ISMRM2018_4433,
annote={ISMRM2018_4433},
pages={4433},
file={ISMRM2018_4433.pdf:ISMRM2018_4433.pdf:PDF},
title={Optimizing the combination of preamplifier input impedance and coil impedance for high-density receive arrays},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4433.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ali Attaran and Kyle Gilbert and Blaine A. Chronik and Ravi S. Menon},
abstract={Low-profile preamplifiers were developed to be used in multichannel coil arrays. Optimizing the combination of preamplifier input impedance and coil impedance for high-density receive arrays indicates that the highest SNR is obtained when using high input-impedance preamplifiers connected directly to high-impedance coils.}
}
@inproceedings{ISMRM2018_4434,
annote={ISMRM2018_4434},
pages={4434},
file={ISMRM2018_4434.pdf:ISMRM2018_4434.pdf:PDF},
title={Design of a passive feed network to increase the transmit efficiency of dipoles at 7 Tesla},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4434.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Irena Zivkovic and Thomas O'Reilly and Wyger Brink and Andrew Webb},
abstract={In this abstract, we presented a new way of feeding a dipole type antenna which increases the transmit efficiency (B
1+per square root maximum SAR). The main radiating antenna element was printed on one side of a dielectric substrate with capacitive coupling to a shorter straight dipole element used as the feed element printed on the opposite side. Indirectly (passively) and directly fed (conventional) meander antennas were fabricated and their performances were compared numerically and experimentally. The indirectly fed dipole antenna exhibited increase in transmit efficiency for straight and meandered dipoles.}
}
@inproceedings{ISMRM2018_4435,
annote={ISMRM2018_4435},
pages={4435},
file={ISMRM2018_4435.pdf:ISMRM2018_4435.pdf:PDF},
title={Automated data acquisition system for f{MRI} resting state de-noising},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4435.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Grace Li Haug and Domenic Cerri and Yen-Yu Ian Shih and SungHo Lee},
abstract={We have developed an automated system for collecting data from monitoring devices for animal functional MRI (fMRI) research to clean the effects of the physiological nuisance signal. Graphical user interface (GUI) is also provided to make a convenient environment for monitoring animal vital signs on one screen. To demonstrate the system’s usefulness, we perform CBV-based resting-state fMRI and compare the changes of temporal signal-to-noise ratio (tSNR) in the striatum between the before and after end-tidal CO
2 (EtCO
2) signal correction using RETROICOR algorithm. The software automates the time synchronization among the collected data and will be expanded to automate the noise filtering process.}
}
@inproceedings{ISMRM2018_4436,
annote={ISMRM2018_4436},
pages={4436},
file={ISMRM2018_4436.pdf:ISMRM2018_4436.pdf:PDF},
title={{FPGA} processors of Parallelized 2D {FFT} suitable for real-time {RARE} image reconstruction},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4436.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Limin Li and Alice M Wyrwicz},
abstract={We report here a new parallelized 2D FFT algorithm suitable for real-time RARE image reconstruction and describe how to implement the algorithm on a Field-Programmable Gate Array (FPGA). We will present the design and testing of these FPGA processors and demonstrate their utility in reconstructing RARE images.}
}
@inproceedings{ISMRM2018_4437,
annote={ISMRM2018_4437},
pages={4437},
file={ISMRM2018_4437.pdf:ISMRM2018_4437.pdf:PDF},
title={On the Properties of Additive Manufacturing Materials for Anatomy Specific 3D-Printed {MRI} Coils},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4437.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Bahareh Behzadnezhad and Bruce D Collick and Nader Behdad and Alan B McMillan},
abstract={Additive manufacturing provides a low-cost and rapid means to translate 3D design into the construction of a prototype. For MRI, this type of manufacturing can be used to construct various components including the structure of RF coils. In this abstract, we characterize the material properties (dielectric constant and loss tangent) of several common 3D-printed plastics and utilize these material properties in full-wave electromagnetic simulations to design and construct a very low-cost subject/anatomy-specific 3D-printed receive-only RF coil that fits close to the body. We show that the anatomy-specific coil exhibits higher signal-to-noise ratio compared to a conventional flat surface coil.
}
}
@inproceedings{ISMRM2018_4438,
annote={ISMRM2018_4438},
pages={4438},
file={ISMRM2018_4438.pdf:ISMRM2018_4438.pdf:PDF},
title={Breast Cancer Diagnosis: A Multiparametric Magnetic Resonance Imaging Model with Dynamic Contrast Enhanced and Diffusion Weighted Imaging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4438.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Katja Pinker-Domenig and Michelle Zhang and Joao V Horvat and Blanca Bernard-Davila and Rosa Elena Ochoa-Albiztegui and Elisabeth A Morris and Sunitha Thakur and Pascal AT Baltzer and Thomas H Helbich},
abstract={To develop a multiparametric MRI model incorporating the ACR BI-RADS recommended descriptors for DCE-MRI, T2-weighted and DW imaging biomarkers for accurate breast cancer diagnosis. A multivariate logistic regression analysis of multiparametric MRI data from 210 breast tumors was performed to determine parameters that jointly predicted malignancy. A multiparametric MRI model incorporating quantitative and qualitative for DCE-MRI [mass margins (p=0.0012), initial EH (p=0.422) and delayed enhancement (0.0065)] and DW imaging biomarkers [ADCmean (p=0.0031)] enables an accurate breast cancer diagnosis. Results indicate that to maximize diagnostic accuracy a multiparametric MRI approach with DWI and DCE sequences must be considered.}
}
@inproceedings{ISMRM2018_4439,
annote={ISMRM2018_4439},
pages={4439},
file={ISMRM2018_4439.pdf:ISMRM2018_4439.pdf:PDF},
title={Initial enhancement in breast ultrafast {DCE}-{MRI} as a marker for malignancy},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4439.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Federico Pineda and Ty O Easley and Hiroyuki Abe and David Schacht and Gregory Karczmar},
abstract={59 patients with dense breasts and suspicious findings on mammography underwent pre-biopsy DCE-MRI including high-temporal-resolution (‘ultrafast’) imaging during the first minute post-contrast. Parameters descriptive of early enhancement (initial slope and initial area under the gadolinium curve) were significantly different between benign and malignant lesions. Ultrafast imaging allowed for measurement of kinetic parameters with respect to the bolus time-of-arrival in the breast; removing dependence on variables such as cardiac output. High-temporal resolution DCE allows accurate measurements of very early enhancement kinetics, when differences between benign and malignant lesions may be largest; this could aid in the evaluation of suspicious breast lesions.}
}
@inproceedings{ISMRM2018_4440,
annote={ISMRM2018_4440},
pages={4440},
file={ISMRM2018_4440.pdf:ISMRM2018_4440.pdf:PDF},
title={Lymph Node Multi-parametric {MRI} Is a Strong Predictor of Pathologic Response to Chemotherapy: {ACRIN}/I-{SPY} Trial},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4440.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Silu Han and Renee F. Cattell and James J. Kang and Thomas Ren and Pauline B. Huang and Haifang Li and Jules A. Cohen and Paul Fisher and Roxanne Palermo and Tim Q. Duong},
abstract={MRI primary breast lesion volume has been shown to be a strong predictor in the response to chemotherapy for invasive breast cancer. However, the prediction accuracy remains low. In this study, we investigated the feasibility of using lymph node volume and signal enhancement ratio as predictors of the chemotherapy response. The result shows that the lymph nodes signal-enhancement ratio is a stronger predictor than lymph node volume and primary in-breast lesion volume.}
}
@inproceedings{ISMRM2018_4441,
annote={ISMRM2018_4441},
pages={4441},
file={ISMRM2018_4441.pdf:ISMRM2018_4441.pdf:PDF},
title={Combined Ultrafast and Steady State {DCE}-{MRI} Differentiates Invasive Breast Cancer Types and Is Associated with Pathological Complete Response to Neoadjuvant Chemotherapy},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4441.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Meredith Sadinski and Natsuko Onishi and Katherine Gallagher and Theodore Hunt and Amita Shukla-Dave and Danny Martinez and Brittany Dashevsky and Elizabeth A Morris and Elizabeth Sutton},
abstract={132 patients with invasive breast cancer were imaged with our DCE-MRI protocol incorporating ultrafast, DISCO imaging of early wash-in phase with standard, steady state DCE-MRI. Heuristic and pharmacokinetic metrics were calculated from the DISCO and steady state images and compared between invasive lobular and invasive ductal carcinomas. Bolus Arrival Time was significantly higher in ILC than in IDC. Association of parameters with pathological complete response to neoadjuvant chemotherapy administered after the imaging exam was investigated for a subset of 25 patients. Heterogeneity-related parameters were significantly higher in the pCR group encouraging further investigation into imaging biomarkers predictive of treatment response.}
}
@inproceedings{ISMRM2018_4442,
annote={ISMRM2018_4442},
pages={4442},
file={ISMRM2018_4442.pdf:ISMRM2018_4442.pdf:PDF},
title={Characterize Tumor Cellularity in Breast Cancer with Diffusion {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4442.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Zezhong Ye and Na Zhao and Joshua Lin and Qingsong Yang and Jeff Viox and Peng Sun and Jianping Lu and Song-Kwei Song},
abstract={Recent consensus suggested breast MRI lacks necessary sensitivity or specificity to detect breast cancer. MRI may over-diagnose breast cancer and result in over-treatment. The novel diffusion MRI histology (D-Histo) method demonstrated its ability to accurately locate lesion and quantify cancer cellularity and afforded greater sensitivity and specificity than ADC did in distinguishing between tumor and benign tissues. D-Histo’s improved diagnostic accuracy thus better guides treatment planning and more accurately measures treatment efficacy.}
}
@inproceedings{ISMRM2018_4443,
annote={ISMRM2018_4443},
pages={4443},
file={ISMRM2018_4443.pdf:ISMRM2018_4443.pdf:PDF},
title={Intravoxel incoherent motion ({IVIM}) and non-Gaussian diffusion {MRI} of the lactating breast},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4443.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Mami Iima and Masako Kataoka and Rena Sakaguchi and Shotaro Kanao and Natsuko Onishi and Makiko Kawai and Katsutoshi Murata and Kaori Togashi},
abstract={The effect of breastfeeding on IVIM and non-Gaussian diffusion MRI was investigated. ADC
0 and sADC values significantly decreased (P < 0.001 and P < 0.001) while K values significantly increased (P < 0.05) post-breastfeeding. fIVIM values significantly increased after breastfeeding (P < 0.01). No significant difference was found in D* values. There was significant heterogeneity in ADC
0 maps post-breastfeeding, both in retroareolar and segmental scores (P < 0.0001 and = 0.0001). IVIM and non-Gaussian diffusion parameters significantly changed between pre- and post-breastfeeding status and care needs to be taken in interpreting DWI data in lactating breasts.}
}
@inproceedings{ISMRM2018_4444,
annote={ISMRM2018_4444},
pages={4444},
file={ISMRM2018_4444.pdf:ISMRM2018_4444.pdf:PDF},
title={Novel parameters of Ultrafast {DCE} {MRI} of the breast using a compressed sensing technique},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4444.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Maya Honda and Masako Kataoka and Natsuko Onishi and Shotaro Kanao and Hajime Sagawa and Mami Iima and Kanae Kawai Miyake and Dominik Nickel and Masakazu Toi and Kaori Togashi},
abstract={We evaluated new parameters of breast ultrafast dynamic contrast-enhanced (UF-DCE) MRI using compressed sensing technique: the maximum slope (MS), time to enhancement (TTE) and the time interval between arterial and venous visualization (AVI). MS was higher and TTE and AVI were shorter in malignant lesions compared to benign lesions, although there were discrepancies among these parameters and BI-RADS based delayed phase patterns. There seemed to be some relevance between these parameters and histopathologic findings.}
}
@inproceedings{ISMRM2018_4445,
annote={ISMRM2018_4445},
pages={4445},
file={ISMRM2018_4445.pdf:ISMRM2018_4445.pdf:PDF},
title={Effect of Contrast Dose on Diagnostic Performance in {DCE}-{MR} Breast Imaging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4445.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Lawrence Dougherty and Elizabeth S. McDonald and Gamaliel Isaac and Thuy-My Thi Le and Mark A. Rosen},
abstract={A retrospective reader study was performed to assess breast MRI diagnostic performance as a function of contrast dose. There was an increase in sensitivity for malignancy with increasing contrast dose with no significant decrease in specificity. Greater confidence in the lesion assessment was also shown by the inter-observer agreement, which increased at the higher doses. Diagnostic performance of DCE-MR breast imaging was greater when subjects received a higher gadolinium dose than the current standard of 0.10 mmol/kg.}
}
@inproceedings{ISMRM2018_4446,
annote={ISMRM2018_4446},
pages={4446},
file={ISMRM2018_4446.pdf:ISMRM2018_4446.pdf:PDF},
title={Diffusional Kurtosis Imaging for Differentiation of Additional Suspicious Lesions on Preoperative Breast {MRI} of Patients with Known Breast Cancer},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4446.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Vivian Youngjean Park and Sungheon G Kim and Eun-Kyung Kim and Hee Jung Moon and Jung Hyun Yoon and Min Jung Kim},
abstract={We investigated the potential of diffusional kurtosis imaging (DKI) and conventional diffusion weighted imaging (DWI) for differentiation of additional suspicious lesions on preoperative breast MRI patients with known breast cancer. This study included 53 pathologically confirmed lesions larger than 10mm in 45 women with known breast cancer. DKI and DWI parameters were compared between lesions. Multiple DKI parameters showed a significant difference between benign vs. invasive breast lesions and a few differed between DCIS vs. invasive breast lesions, with high specificity. However, DKI and DWI could not distinguish DCIS from benign lesions and may have lower potential in this subgroup}
}
@inproceedings{ISMRM2018_4447,
annote={ISMRM2018_4447},
pages={4447},
file={ISMRM2018_4447.pdf:ISMRM2018_4447.pdf:PDF},
title={Effectiveness of 6 monthly {MRI} screening for breast cancer in women with a {BRCA} mutation – a numerical simulation.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4447.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Keith S Cover and Joost PA Kuijer and Mark MB Hofman and Jeroen Veltman and Monique D Dorrius and Ritse M Mann and Katya M Duvivier},
abstract={Currently, MRI screening for breast cancer in women with a BRCA mutation is annually. However, studies on tumour doubling times indicate that some tumours grow faster. To assess the value of more frequent screening we numerically simulated annual and 6 monthly screening based on reported tumour doubling times in women with the BRCA mutation. For annual screening, the simulation predicted 14\% of cancers with poor prognosis (diameter > 2 cm), in line with clinical studies. For 6 monthly screening the simulation predicted 3\% with poor prognosis. Therefore, 6 monthly screening should yield a substantial reduction in tumours with a poor prognoses .}
}
@inproceedings{ISMRM2018_4448,
annote={ISMRM2018_4448},
pages={4448},
file={ISMRM2018_4448.pdf:ISMRM2018_4448.pdf:PDF},
title={The Value of {DKI} and {IVIM} Quantitative Parameters in Differentiating Breast Lesions and Correlations with Histopathologic Factors: A Preliminary Study},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4448.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Chenglu Ke and Shunan Che and Jing Li and Lizhi Xie},
abstract={The current study aimed to evaluate the application of diffusion kurtosis imaging (DKI) and intravoxel incoherent motion (IVIM) in the differential diagnosis of breast lesions. The association of DKI and IVIM derived parameters were compared with pathological types, histologic grade and Ki-67 expression of primary breast cancers. The results indicated that MD, MK, D and f are capable of distinguishing benign from malignant breast lesions. Furthermore, significant correlations were observed between MD and different histologic grade and Ki-67 expression, repsectivley.}
}
@inproceedings{ISMRM2018_4449,
annote={ISMRM2018_4449},
pages={4449},
file={ISMRM2018_4449.pdf:ISMRM2018_4449.pdf:PDF},
title={Clinical Value of Reduced field-of-view Sagittal Delayed-Enhanced Breast {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4449.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Xiuhua Lv and Feihan Jiao and Junqing Xu and Hong Yin},
abstract={This study aimed to investigate the clinical value of reduced field-of-view (rFOV) sagittal delayed enhanced MRI in diagnosing of breast tumor. we assessed two groups with and without rFOV sagittal delayed enhanced scanning with a time interval of at least six months.In our study, the detection rate, specificity and positive predictive value of the test group with rFOV were significantly higher than that of the control group without rFOV. rFOV sagittal delayed enhanced scanning indicated clinical value in detecting and differential diagnosis of benign and malignant breast tumors.}
}
@inproceedings{ISMRM2018_4450,
annote={ISMRM2018_4450},
pages={4450},
file={ISMRM2018_4450.pdf:ISMRM2018_4450.pdf:PDF},
title={Quantitative evaluation of Diffusion tensor and Intravoxel incoherent motion ({IVIM}) magnetic resonance imaging in cyclic mastalgia in premenopausal young women},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4450.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Qiuju Fan and Hui Tan and Nan Yu and Yuxin Lei and Shaoyu Wang and Yong YU},
abstract={Severe breast pain may significantly affect activities related to life quality, while its aetiology is still poorly understand. DTI and IVIM can provide valuable information on tissue microstructure, microcirculation and pathophysiology that has been extensively used on the breast cancer
[1].}
}
@inproceedings{ISMRM2018_4451,
annote={ISMRM2018_4451},
pages={4451},
file={ISMRM2018_4451.pdf:ISMRM2018_4451.pdf:PDF},
title={Breast Lesion Detection and Characterization with Contrast-Enhanced Magnetic Resonance Imaging: Prospective Randomized Intra-individual Comparison of Gadoterate Meglumine versus Gadobenate Dimeglumine at 3 Tesla},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4451.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Paola Clauser and Thomas H. Helbich and Panagiotis Kapetas and Maria Bernathova and Katja Pinker and Pascal A.T. Baltzer},
abstract={The aim of our study was to compare a 0.075 mmol/kg dose of gadobenate dimeglumine, with a 0.15 mmol/kg dose of gadoterate meglumine for breast lesion detection and characterization at 3T-MRI. Patients included underwent two examinations, 24-72h apart, one with gadobenate and one with gadoterate administered in randomized order. Three readers evaluated the examinations and diagnostic performance was calculated and compared. 104 women with 142 histologically verified breast lesions (109 malignant, 33 benign) were included. Detection with gadobenate was comparable to gadoterate (p>0.165). Gadobenate demonstrated significantly higher specificity and accuracy (p<0.007). Multivariate analysis demonstrated reader-independent superior diagnostic accuracy with gadobenate.}
}
@inproceedings{ISMRM2018_4452,
annote={ISMRM2018_4452},
pages={4452},
file={ISMRM2018_4452.pdf:ISMRM2018_4452.pdf:PDF},
title={Quantitative Predictors of Response to Neoadjuvant Chemotherapy on Dynamic Contrast-Enhanced Breast {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4452.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Hyung Won Choi and Melissa Joines and Anne Hoyt and Laura Doepke and Jane Dascalos and Cheryce Fischer and Nanette DeBruhl and Nazanin Yaghmai and Kara Lee Pool and Bo Li and James Sayre and Stephanie Lee-Felker},
abstract={In this IRB-approved, HIPAA-compliant retrospective study, 63 consecutive women with newly diagnosed breast cancer undergoing neoadjuvant chemotherapy with pre- and post- chemotherapy breast MRI on a 3.0 Tesla scanner prior to surgery at our institution between January 2013 and December 2015 were included for analysis. Decrease in tumor size, decrease in peak enhancement, increase in time to peak, decrease in wash in and decrease in wash out on post-chemotherapy breast MRIs were predictive of pathologic complete response on surgical pathology, a surrogate for prognosis.}
}
@inproceedings{ISMRM2018_4453,
annote={ISMRM2018_4453},
pages={4453},
file={ISMRM2018_4453.pdf:ISMRM2018_4453.pdf:PDF},
title={Magnetization Transfer {MRI} of Breast Cancer Response to Neoadjuvant Therapy: Preliminary Results},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4453.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jack Virostko and Anna Sorace and Chengyue Wu and Stephanie Barnes and Angela Jarrett and Debra Patt and Boone Goodgame and Sarah Avery and Thomas E Yankeelov},
abstract={Magnetization transfer MRI (MT-MRI) may be sensitive to changes in the macromolecular content of tumors and the extracellular matrix that occur during neoadjuvant therapy for breast cancer. We demonstrate in a pilot population of breast cancer patients that the magnetization transfer ratio declines after the first cycle of chemotherapy in women who achieve response to therapy, while the magnetization transfer ratio increases in tumors that do not respond to therapy.}
}
@inproceedings{ISMRM2018_4454,
annote={ISMRM2018_4454},
pages={4454},
file={ISMRM2018_4454.pdf:ISMRM2018_4454.pdf:PDF},
title={Feasibility of multispectral spin echo breast quantitative susceptibility mapping: an alternative to post-biopsy mammogram after {MR}-guided breast biopsy},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4454.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Sarah Eskreis-Winkler and Katherine Simon and Youngwook Kee and Junghun Cho and Thanh Nguyen and Pascal Spincemaille and Michele Drotman and Yi Wang},
abstract={During MR-guided breast biopsy, a titanium biopsy marker is deployed in the biopsy cavity to mark the spot. Conventional MR cannot distinguish between these markers and the pockets of air that are often introduced during the biopsy, necessitating a subsequent mammogram to confirm biopsy marker location. Our goal is to replace post-biopsy mammogram with a short MR protocol leveraging the difference in magnetic susceptibility between titanium and air in order to distinguish them as sources of MR signal voids. To this end, we generate quantitative susceptibility maps (QSM) using 3D fast spin echo acquired at four frequency offsets.}
}
@inproceedings{ISMRM2018_4455,
annote={ISMRM2018_4455},
pages={4455},
file={ISMRM2018_4455.pdf:ISMRM2018_4455.pdf:PDF},
title={Comparison of Radial and Cartesian Acquisitions for Visualization of the Axilla in Breast {MRI}: Reader Study},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4455.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Pingni Wang and Roberta M Strigel and Makiko Kawai and Ty A Cashen and Julia V Velikina and Kang Wang and Frank Korosec and Urvi A Tailor and Jillian A Karow and Kevin M Johnson and Andre Fischer and James H Holmes},
abstract={Dynamic contrast-enhanced (DCE) MRI using conventional Cartesian sampling is used in routine clinical practice due to its high sensitivity for breast cancer. However, ghosting artifacts caused by cardiac motion can obscure the axilla, making interpretation of this area more difficult and potentially obscuring findings. Radial acquisitions are less motion sensitive due to more frequent sampling of the center of k-space and prior work has suggested these methods for breast MRI. In this study, we report results from a reader study to assess image quality of a 3D stack-of-stars radial acquisition compared with Cartesian imaging for breast MRI.}
}
@inproceedings{ISMRM2018_4456,
annote={ISMRM2018_4456},
pages={4456},
file={ISMRM2018_4456.pdf:ISMRM2018_4456.pdf:PDF},
title={One millimeter isotropic breast {DWI} combining readout-segmented {EPI} and super-resolution},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4456.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Maya DELBANY and Julie POUJOL and Aurélien BUSTIN and Isabelle THOMASSIN-NAGGARA and Jacques FELBLINGER and Pierre-André VUISSOZ and Freddy ODILLE},
abstract={High-resolution diffusion-weighted imaging (DWI) has the potential to improve the specificity of breast MRI. In this work a method is proposed for 3D isotropic DWI of the whole breasts. Three breast DWI datasets were acquired using a readout-segmented DW-EPI sequence (rs-EPI) with thick slices (3 mm) and 1mm-shifts in the slice direction. A high isotropic resolution (1x1x1 mm
3) DWI dataset was reconstructed using a super-resolution reconstruction (SRR) on the low-resolution anisotropic acquisiitons, with different regularization schemes (Tikhonov and Beltrami, an edge-preserving constraint). This study shows the benefit of this strategy compared to native acquisitions with 1 mm slice thickness. A quantitative SNR evaluation is presented.}
}
@inproceedings{ISMRM2018_4457,
annote={ISMRM2018_4457},
pages={4457},
file={ISMRM2018_4457.pdf:ISMRM2018_4457.pdf:PDF},
title={Addition of in-vivo proton {MRS} to {DCEMRI} increases the sensitivity of cancer detection in breast cancer patients especially in cases of indeterminate dynamic {MRI} findings.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4457.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Naranamangalam R Jagannathan and Khusbhu Agarwal and Uma Sharma and Smriti Hari and Vurthaluru Seenu and Sandeep Mathur and Siddhartha D Gupta and Rajinder Parshad},
abstract={Potential of addition of in-vivo proton (
1H) MRS to DCEMRI data especially in indeterminate DCE findings was evaluated. MRS and DCEMRI data of 56 breast cancer patients were included in the analysis. 47/56 cases showed type III curve indicating cancer with a sensitivity of 83.9\%. MRS showed true positive findings of cancer in 44/47 cases. Among 9 indeterminate DCE cases, MRS was positive for cancer in 6 cases, implying that 50/56 cases were true positive for cancer with 89.3\% sensitivity. Addition of MRS to DCEMRI data increases the sensitivity of cancer detection especially in indeterminate DCE findings.}
}
@inproceedings{ISMRM2018_4458,
annote={ISMRM2018_4458},
pages={4458},
file={ISMRM2018_4458.pdf:ISMRM2018_4458.pdf:PDF},
title={Quantitative analysis of ultra-fast {DCE}-{MRI} to identify vascular inputs and outputs in breast tumors},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4458.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Chengyue Wu and Federico Pineda and Gregory Karczmar and Thomas Yankeelov},
abstract={Identifying and characterizing vascular inputs and outputs in tumors would be useful in both the diagnostic and prognostic settings. In this contribution, we propose a novel methodology that combines vessel detection with analysis of ultra-fast DCE-MRI data to integrate both morphological and functional information of tumor associated vessels to identify those that serve as inputs and outputs to breast tumors.}
}
@inproceedings{ISMRM2018_4459,
annote={ISMRM2018_4459},
pages={4459},
file={ISMRM2018_4459.pdf:ISMRM2018_4459.pdf:PDF},
title={Comparison of 1.0M Gadobutrol and 0.5M Gadoteridol for Kinetic Parameters on Breast Dynamic Contrast Enhanced Magnetic Resonance Imaging at 3T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4459.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Hajime Sagawa and Masako Kataoka and Shotaro Kanao and Natsuko Onishi and Maya Honda and Dominik Nickel and Masakazu Toi and Katsuhiko Ueda and Kaori Togashi},
abstract={The contrast effects of 1.0M gadobutrol were compared to that of 0.5M gadoteridol in breast cancer at 3T using hybrid MRI protocol which combined conventional DCE (C-DCE) with ultrafast DCE (UF-DCE). The significant differences were observed only in UF-DCE, maximum enhancement ratio (MER) and maximum slope (MS). The slightly higher peak relative enhancement produced by gadobutrol compared with gadoteridol might help in the detection and evaluation of breast lesions in the earlier phases.}
}
@inproceedings{ISMRM2018_4460,
annote={ISMRM2018_4460},
pages={4460},
file={ISMRM2018_4460.pdf:ISMRM2018_4460.pdf:PDF},
title={Quantitative Analysis of Peri-Tumor Interface Fat and the Volumetric Fat Percentage and Contrast Enhancement in Three Peri-Tumoral Shells to Differentiate Molecular Subtypes of Breast Cancer},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4460.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jeon-Hor Chen and Yang Zhang and Siwa Chan and Dah-Cherng Yeh and Min-Ying Su},
abstract={A 3D morphological analysis method was developed to analyze the fat content on tumor boundary interface and in different peri-tumoral shells away from the tumor. A total of 114 mass type breast cancers were analyzed, including 87 HR(+), 13 HR(-)HER2(+) and 14 TN. The volumetric fat percentage in three shells surrounding the tumor: 150\%-100\%, 200\%-150\%, 250\%-200\% of the tumor convex hall were measured, also the mean contrast enhancement in fibroglandular tissue contained within three shells were measured. The peri-tumor fat content and contrast enhancement is the highest in the most aggressive TN tumors compared to other subtypes.}
}
@inproceedings{ISMRM2018_4461,
annote={ISMRM2018_4461},
pages={4461},
file={ISMRM2018_4461.pdf:ISMRM2018_4461.pdf:PDF},
title={Effectivity and correlation of parameters derived from diffusion kurtosis imaging and quantitative dynamic contrast-enhanced {MRI} in the breast imaging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4461.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ting Li and Siying Wang and Yun Xiong and Kangan Li},
abstract={The aim of this study is to evaluate the diagnostic efficacy of 3.0T MRI diffusion kurtosis imaging and quantitative dynamic contrast enhancement in benign and malignant breast lesions and to explore the differential diagnosis ability of different pathological types and molecular subtype lesions. The results showed that 3.0T MRI diffusion kurtosis imaging and dynamic contrast-enhanced quantitative hemodynamic parameters are of great value in the differential diagnosis of benign and malignant breast lesions. The combination of both can significantly improve the diagnostic efficiency.
}
}
@inproceedings{ISMRM2018_4462,
annote={ISMRM2018_4462},
pages={4462},
file={ISMRM2018_4462.pdf:ISMRM2018_4462.pdf:PDF},
title={Highly Accelerated Dynamic Acquisition of 3D Grid-Tagged He-3 Lung Images Using Compressed Sensing},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4462.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={William J Garrison and Kun Qing and Sina Tafti and John P Mugler and Y Michael Shim and Jaime F Mata and Gordon D Cates and Eduard E de Lange and Craig H Meyer and Jing Cai and G Wilson Miller},
abstract={Radiotherapy in the context of lung cancer can become less effective if lung biomechanics are not well-characterized. MRI of grid-tagged, inhaled hyperpolarized He-3 gas provides images with strong signal at the tag locations, allowing time-resolved tracking of regional lung motion that can be used to inform strategies for precision radiotherapy. The present work demonstrates rapid acquisition of high-quality 3D grid-tagged images obtained with 8-fold under-sampling and reconstructed using compressed sensing. The dramatic imaging acceleration inherent in this technique allows multiple 3D image sets to be acquired during a single breath-hold, effectively permitting 4D-MRI of lung motion during exhalation.}
}
@inproceedings{ISMRM2018_4463,
annote={ISMRM2018_4463},
pages={4463},
file={ISMRM2018_4463.pdf:ISMRM2018_4463.pdf:PDF},
title={High Ventilation Percent on Hyperpolarized Helium-3 {MRI} is Associated with Reduced One-Year Risk of Asthma Exacerbation},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4463.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={David Mummy and Wei Zha and Shannon Kehoe and Guy Olson and Ronald Sorkness and Nizar Jarjour and Mark Schiebler and Loren Denlinger and Michael Evans and Sean Fain},
abstract={We assessed the high ventilation percent (HVP) as well as the ventilation defect percent (VDP) on hyperpolarized (HP)
3He MRI and found that both measures were associated with exacerbation in the year following imaging, with the HVP exhibiting the stronger association. Both measures were strong predictors relative to other measures of lung function. These findings suggest that HVP is sensitive to one-year risk of asthma exacerbation and is a potential biomarker of asthma instability.}
}
@inproceedings{ISMRM2018_4464,
annote={ISMRM2018_4464},
pages={4464},
file={ISMRM2018_4464.pdf:ISMRM2018_4464.pdf:PDF},
title={Bridging the gap between lung small conducting and acinar airways – combined in vivo lung morphometry with hyperpolarized 3He {MRI} and {CT} studies.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4464.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Dmitriy A Yablonskiy and Alexander L Sukstanskii and James D Quirk and Chase Hall and Mario Castro and David S Gierada and Vanessa Curtis and Miranda Kirby and Eric A Hoffman and Roger D Yusen},
abstract={Air trapping (retention of inspired air during expiration) is usually associated with small conducting airways disease. However, limited information exists on integrity of acinar airways (i.e., alveolar ducts and sacs) in lung regions affected by air trapping. In this study we combine novel CT and MRI metrics to understand the sub-lobar level relationships between MR-derived acinar anatomy and CT-based air trapping metrics. We studied healthy non-smokers, smokers and COPD subjects and found significant associations between air trapping and acinar airways shallowing in upper and middle lungs in all groups but very little association in lower lung, except for COPD patients.}
}
@inproceedings{ISMRM2018_4465,
annote={ISMRM2018_4465},
pages={4465},
file={ISMRM2018_4465.pdf:ISMRM2018_4465.pdf:PDF},
title={Comparison of {CT} ventilation and Hyperpolarised Gas {MRI}: Effects of breathing manoeuvre},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4465.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Bilal A. Tahir and Helen Marshall and Paul J. Hughes and Guilhem Collier and Rob H. Ireland and Jim M. Wild},
abstract={Image registration of lung CT images acquired at different inflation levels has been proposed as a surrogate method to map lung ‘ventilation’. However, this technique requires validation against established ventilation imaging modalities such as hyperpolarized gas MRI. Variations in lung inflation may affect regional lung function as imaged with the two modalities. Here, we evaluate the impact of the lung inflation level during MRI when comparing gas MRI and CT ventilation for a cohort of 7 patients with asthma.}
}
@inproceedings{ISMRM2018_4466,
annote={ISMRM2018_4466},
pages={4466},
file={ISMRM2018_4466.pdf:ISMRM2018_4466.pdf:PDF},
title={Mapping of pseudo-compliance using hyperpolarized 129Xe morphometry in the rat lung},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4466.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Andras Lindenmaier and Brandon Zanette and Elaine Stirrat and Brian Kavanagh and Giles Santyr},
abstract={Performing 129Xe morphometry at multiple pressures allows for direct mapping of microstructural changes and micromechanical properties of the lung (eg. pseudo-compliance) in both health and disease. In the present study, the effects of posture and gravity on the linear portion of lung pseudo-compliance are investigated using this approach in healthy mechanically-ventilated rats. Spatial gradients in lung pseudo-compliance due to gravity and posture are shown to vary, consistent with the expectations that the lungs are denser dorsally due to the weight above. Scaled regional pseudo-compliance is shown to be in agreement with whole lung compliance measured using 1H MRI.}
}
@inproceedings{ISMRM2018_4467,
annote={ISMRM2018_4467},
pages={4467},
file={ISMRM2018_4467.pdf:ISMRM2018_4467.pdf:PDF},
title={Depiction of Gas Flow Patterns in Pulmonary Dynamic Hyperpolarized Gas {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4467.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Sa Xiao and He Deng and Caohui Duan and Junshuai Xie and Xianping Sun and Chaohui Ye and Xin Zhou},
abstract={Dynamic hyperpolarized gas MRI of lung is able to visualize the dynamic changes of pulmonary morphology during the ventilation process, which provides the important information about lung physiology and pathophysiology. However, there is a lack of an effective method to depict the gas flow patterns in the whole lung. In this work, we propose a motion field calculation method based on the pulmonary gas flow properties, which can acquire the velocity and direction of gas flow. The performance of the proposed method is investigated experimentally.}
}
@inproceedings{ISMRM2018_4468,
annote={ISMRM2018_4468},
pages={4468},
file={ISMRM2018_4468.pdf:ISMRM2018_4468.pdf:PDF},
title={An Interleaved Spiral-{IDEAL} Approach for Physiological Gas Exchange Imaging in Humans using a Single Breath-hold of Hyperpolarized 129Xe},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4468.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Brandon Zanette and Giles Santyr},
abstract={Pulmonary disease involving lung injury (e.g. ventilator-induced lung injury, radiation-induced lung injury, interstitial lung disease) can lead to pulmonary dysfunction which may not be detectable using proton pulmonary magnetic resonance imaging or ventilation imaging with hyperpolarized noble gases. The solubility of
129Xe in biological tissues and resultant chemical shifts allow for the quantification of physiological gas exchange which hold promise for the clinical evaluation of early pulmonary dysfunction. In this work we demonstrate an approach for dissolved-phase
129Xe gas exchange imaging within a single breath-hold in healthy human volunteers.}
}
@inproceedings{ISMRM2018_4469,
annote={ISMRM2018_4469},
pages={4469},
file={ISMRM2018_4469.pdf:ISMRM2018_4469.pdf:PDF},
title={Clinical Translation of 3D Spiral-{IDEAL} for Single Breath-hold Imaging of Gas and Dissolved-Phase Hyperpolarized 129Xe in Human Lungs},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4469.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Brandon Zanette and Giles Santyr},
abstract={Spiral-IDEAL is a fast and efficient technique for imaging dissolved-phase hyperpolarized
129Xe in tissue/blood plasma (T/P) and red blood cell (RBC) compartments of the lung. Previously, spiral-IDEAL has been limited to pre-clinical rodent models using multi-breath techniques not suitable for human subjects. In this work we optimize and demonstrate clinical translation of spiral-IDEAL for single breath-hold
129Xe imaging of human subjects. We compare and contrast several interleaved imaging strategies. Furthermore, we also demonstrate 3D spiral-IDEAL for simultaneous volumetric imaging of gas, T/P and RBC compartments.}
}
@inproceedings{ISMRM2018_4470,
annote={ISMRM2018_4470},
pages={4470},
file={ISMRM2018_4470.pdf:ISMRM2018_4470.pdf:PDF},
title={Dynamic {MRI} of Hyperpolarized Xenon-129 Uptake in the Human Kidney Using a Dedicated Transmission-Only-Reception-Only Array at 3 Tesla},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4470.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jorge Chacon-Caldera and Adam Maunder and Madhwesha Rao and Graham Norquay and Oliver I. Rodgers and Matthew Clemence and Claudio Puddu and Lothar R. Schad and Jim M. Wild},
abstract={Dissolved hyperpolarized
129Xe MRI is an emerging technique. Inhaled xenon dissolves in the blood in the lungs and with a long T
1 (8s) has the potential for imaging other organs that are well perfused such as the kidneys. An RF coil array was designed with an anatomically focused transmit field to avoid RF depolarization of dissolved xenon in its transit from the lungs whilst providing local sensitivity over the kidney. Dynamic imaging of dissolved
129Xe in kidneys was performed in 2 healthy volunteers. The signal evolution in the cortex was obtained which might provide novel physiological insight into kidney physiology.}
}
@inproceedings{ISMRM2018_4471,
annote={ISMRM2018_4471},
pages={4471},
file={ISMRM2018_4471.pdf:ISMRM2018_4471.pdf:PDF},
title={Hyperpolarized 129Xe Gas Exchange Imaging of the Human Lung using {IDEAL} with Spiral k-space Sampling},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4471.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ozkan Doganay and Mitchell Chen and Tahreema Matin and Marzia Rigolli and Julie-Ann Phillips and Anthony McIntyre and Fergus V. Gleeson},
abstract={This proof of concept study describes implementation and analysis of an IDEAL (Iterative Decomposition of water and fat with Echo Asymmetry and Least-square estimation) based imaging technique for imaging hyperpolarized Xenon-129 (HPX) gas ventilation and dissolved phase compartments in human lungs. The time-series IDEAL imaging approach was tested in a healthy subject corroborating with Bloch equations and a numerical gas-exchange model showing that HPX gas ventilation and dissolved phase compartment images can be obtained and the gas-transfer dynamics can be measured, in a single breath-hold interval of 8 seconds using 1L of HPX gas with polarization of ~10\%.}
}
@inproceedings{ISMRM2018_4472,
annote={ISMRM2018_4472},
pages={4472},
file={ISMRM2018_4472.pdf:ISMRM2018_4472.pdf:PDF},
title={Retrospective removal of gas-phase signal from pulmonary dissolved-phase Hyperpolarized 129Xe images},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4472.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jeff Kammerman and Andrew D Hahn and Sean B Fain},
abstract={Dissolved-phase hyperpolarized xenon-129 imaging provides regional information on gas exchange between the lung airspaces, parenchymal tissues and blood stream. Current spectroscopic techniques require that the dissolved-phase 129Xe signal be acquired with no gas-phase excitation. However, the short T
2* of the dissolved-phase requires short RF pulses, limiting the spectral selectivity achievable. This, combined with the high spin density of the gas-phase relative to the dissolved-phase, leads to unwanted gas-phase excitation. In this work, we retrospectively remove contaminant gas-phase signal from both simulated and human subject images using a multi-echo acquisition with iterative estimation of the contaminant gas-phase signal.}
}
@inproceedings{ISMRM2018_4473,
annote={ISMRM2018_4473},
pages={4473},
file={ISMRM2018_4473.pdf:ISMRM2018_4473.pdf:PDF},
title={The Effect of Signal to Noise Ratio on Linear-binning and Adaptive k-means Quantification of Hyperpolarized
129Xe Ventilation {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4473.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Mu He and Fei Tan and Wei Zha and Leith Rankine and Sean Fain and Bastiaan Driehuys},
abstract={
129Xe ventilation MRI lacks a reference standard. Here, we circumvent this problem in part by comparing and evaluating the robustness of two independent methods for quantifying ventilation – linear-binning and adaptive k-means - by adding MR noise to the source images until the algorithms fail. Results at different noise levels were compared to that quantified using the original high signal-to-noise ratio (SNR) ventilation image. We found that both methods provide robust quantification until SNR is less than 1.7 ± 0.8 for the linear-binning method and 2.1 ± 1.2 for the uncorrected adaptive k-means method.}
}
@inproceedings{ISMRM2018_4474,
annote={ISMRM2018_4474},
pages={4474},
file={ISMRM2018_4474.pdf:ISMRM2018_4474.pdf:PDF},
title={Voxel-based mapping of lung microstructural parameters using hyperpolarized 129Xe dissolved-phase imaging in healthy volunteers and chronic obstructive pulmonary disease patients},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4474.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Agilo Luitger Kern and Marcel Gutberlet and Andreas Voskrebenzev and Filip Klimes and Alexander Rotärmel and Frank Wacker and Jens Hohlfeld and Jens Vogel-Claussen},
abstract={Chemical shift saturation recovery (CSSR) spectroscopy is a method, which is able to assess lung microstructure using
129Xe gas uptake and to discriminate between healthy volunteers and chronic obstructive pulmonary disease (COPD) patients. However, the absent spatial encoding of standard CSSR spectroscopy poses a limitation of the method for detecting early disease. A method for voxel-based mapping of lung microstructural parameters is proposed. Preliminary data from a study in healthy volunteers and COPD patients employing both CSSR mapping and spectroscopy are presented. Whole-lung median wall thickness and surface-to-volume ratio are highly reproducible and correlate significantly with global values from spectroscopy in COPD patients.}
}
@inproceedings{ISMRM2018_4475,
annote={ISMRM2018_4475},
pages={4475},
file={ISMRM2018_4475.pdf:ISMRM2018_4475.pdf:PDF},
title={Hyperpolarized 129Xe {MR} spectroscopy of the human lung in healthy volunteers and patients with chronic obstructive pulmonary disease ({COPD}): investigation of lung microstructure},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4475.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Agilo Luitger Kern and Marcel Gutberlet and Andreas Voskrebenzev and Filip Klimes and Frank Wacker and Jens Hohlfeld and Jens Vogel-Claussen},
abstract={The NMR line shape in the lung parenchyma exhibits significant broadening due to numerous jumps in magnetic susceptibility. The purpose of this work was to extract this line shape from the
129Xe dissolved-phase spectrum. Free induction decays were acquired in healthy volunteers and COPD patients and a model function including two resonances and a superimposed frequency distribution was fitted to the time-domain data. Both second moment and skewness of the fitted frequency distribution were significantly elevated in COPD patients. The ratio of
129Xe in red blood cells and lung tissue was significantly reduced in COPD patients.}
}
@inproceedings{ISMRM2018_4476,
annote={ISMRM2018_4476},
pages={4476},
file={ISMRM2018_4476.pdf:ISMRM2018_4476.pdf:PDF},
title={Quantifying Changes in Time-Resolved Hyperpolarized
129Xe Spectroscopy among Healthy Volunteers, Subjects with Idiopathic Pulmonary Fibrosis and Subjects with Pulmonary Arterial Hypertension},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4476.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Elianna Bier and Scott Robertson and Geoff Schrank and Craig Rackley and Joseph Mammarappallil and Sudarshan Rajagopal and H. Page McAdams and Bastiaan Driehuys},
abstract={The temporal dynamics of
129Xe spectroscopy were examined by collecting FIDs during inhalation, breath-hold and exhalation. These FIDs were fit to a Voigt model to extract four spectral parameters (amplitude, chemical shift, linewidth and phase) for the airspace, barrier and RBC
129Xe resonances. The RBC resonance parameters exhibited oscillations at the cardiac frequency which were quantified by peak-to-peak amplitudes. IPF subjects exhibited larger signal amplitude, chemical shift and phase oscillations than healthy or PAH subjects. This indicates that
129Xe transfer spectroscopy is differentially affected by cardiopulmonary dynamics such that the causes of gas exchange impairment can be distinguished.}
}
@inproceedings{ISMRM2018_4477,
annote={ISMRM2018_4477},
pages={4477},
file={ISMRM2018_4477.pdf:ISMRM2018_4477.pdf:PDF},
title={Repeatability of Pulmonary Functional Metrics of Gas-exchange Measured with Hyperpolarized Xenon-129 {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4477.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Andrew Hahn and Jeff Kammerman and Michael Evans and Wei Zha and David Mummy and Robert V. Cadman and Sean Fain},
abstract={To advance hyperpolarized Xenon-129 MRI as a robust tool for probing pulmonary gas-exchange in lung diseases, establishing repeatability of quantitative ratios and regional metrics is critical. Repeatability was assessed using Bland-Altman analysis. Average inter-visit tissue-to-gas, red blood cell-to-gas (RBC-to-gas) and RBC-to-tissue ratios were highly repeatable; the primary source of variation was due to lung inflation volume variations, suggesting consistency of breath-hold coaching and dose delivery is important. Regional distribution of measures was also qualitatively well-matched between visits. Demographic factors may also influence these measures; our preliminary data indicate a significant relationship between RBC-to-tissue ratio and subject age.}
}
@inproceedings{ISMRM2018_4478,
annote={ISMRM2018_4478},
pages={4478},
file={ISMRM2018_4478.pdf:ISMRM2018_4478.pdf:PDF},
title={A Clinical-Scale Thermally Polarized
129Xe Phantom for Quality Assurance in Multi-Center Hyperpolarized Gas {MRI} Trials},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4478.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Naomi Morales Medina and Ziyi Wang and Mu He and Geoffry Schrank and John Nouls and Elianna A. Bier and Scott H. Robertson and Ralph Hashoian and John Mugler and Bastiaan Driehuys},
abstract={Hyperpolarized
129Xe-MRI is emerging as a promising method to quantify pulmonary function, but the transient nature of its signal makes routine quality assurance tasks challenging. With increasing interest in multi-center deployment of this technology, it is critical to developtools to characterize
129Xe imaging performance across sites and platforms. Here, we demonstrate a robust, portable, clinical-scale thermally-polarized
129Xe phantom and integrated loader shell. Its utility is demonstrated for characterizing human lung imaging coils and enabling routine 2D- QA scans in one-minute. On longer timescales, 3D-imaging is feasible to evaluate
129Xe coil sensitivity profiles.}
}
@inproceedings{ISMRM2018_4479,
annote={ISMRM2018_4479},
pages={4479},
file={ISMRM2018_4479.pdf:ISMRM2018_4479.pdf:PDF},
title={Assessing the Impact of Acid Aspiration with Hyperpolarized Xenon-129 Dissolved-Phase {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4479.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Kai Ruppert and Hooman Hamedani and Faraz Amzajerdian and Luis Loza and Yi Xin and Ian F. Duncan and Harilla Profka and Sarmad Siddiqui and Mehrdad Pourfathi and Maurizio F. Cereda and Stephen Kadlecek and Rahim R. Rizi},
abstract={Acid aspiration frequently occurs in critically ill patients and can give rise to severe acute lung injury. In this study, we investigated whether hyperpolarized xenon-129 dissolved-phase MRI provides the necessary sensitivity to assess acid aspiration and associated pneumonitis in a rabbit model. We observed changes that most likely corresponded to the formation of interstitial edema as part of an inflammatory response. In particular, perilesional areas of high xenon uptake may reflect tissue at risk of secondary ventilator-induced injury.}
}
@inproceedings{ISMRM2018_4480,
annote={ISMRM2018_4480},
pages={4480},
file={ISMRM2018_4480.pdf:ISMRM2018_4480.pdf:PDF},
title={Investigating Pulmonary Gas Transport Processes with Hyperpolarized Xenon-129 Dissolved-Phase {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4480.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Kai Ruppert and Hooman Hamedani and Faraz Amzajerdian and Luis Loza and Yi Xin and Ian F. Duncan and Harilla Profka and Sarmad Siddiqui and Mehrdad Pourfathi and Stephen Kadlecek and Rahim R. Rizi},
abstract={Several hyperpolarized xenon-129 (HXe) MRI techniques have been developed for characterizing lung function through the observation of parenchymal xenon gas uptake, but these methods tend to provide only a snapshot of a steady-state distribution of the xenon signal within the lung parenchyma. In this study, we investigated the feasibility of extracting gas-transport maps from the relative signal changes between two dissolved-phase images captured with different acquisition parameters. We demonstrated how the acquisition parameters of a suitably-designed HXe MRI pulse sequence can be harnessed for tracing pulmonary gas transport processes and potentially quantifying them at an unprecedented level.}
}
@inproceedings{ISMRM2018_4481,
annote={ISMRM2018_4481},
pages={4481},
file={ISMRM2018_4481.pdf:ISMRM2018_4481.pdf:PDF},
title={Using Regional Gas-Phase Saturation to Localize Hyperpolarized Xenon-129 Spectroscopy Measurements},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4481.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Kai Ruppert and Hooman Hamedani and Faraz Amzajerdian and Luis Loza and Yi Xin and Ian F. Duncan and Harilla Profka and Sarmad Siddiqui and Mehrdad Pourfathi and Stephen Kadlecek and Rahim R. Rizi},
abstract={Chemical Shift Saturation Recovery MR spectroscopy is becoming a powerful tool for quantifying alveolar gas exchange, but is currently predominantly used for whole-lung assessments. In this study, we investigated the feasibility of regional gas-phase saturation as a tool for coarse spatial localization, testing its utility in a rat model of radiation-induced lung injury. We found a large decrease in the ratio between the red-blood-cell and tissue / plasma peaks in the irradiated lung relative to the lungs in a healthy animal. Our approach might be particularly useful for assessing highly heterogeneous disease patterns (radiation-induced lung injuries, lung transplants, etc.).}
}
@inproceedings{ISMRM2018_4482,
annote={ISMRM2018_4482},
pages={4482},
file={ISMRM2018_4482.pdf:ISMRM2018_4482.pdf:PDF},
title={Linear binning maps for image analysis of pulmonary ventilation with hyperpolarized gas {MRI}: transferability and clinical applications},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4482.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Guilhem Jean Collier and Laure Acunzo and Laurie J Smith and Paul J Hughes and Graham Norquay and Ho-Fung Chan and Alberto M Biancardi and Helen Marshall and Jim M Wild},
abstract={This work applies a clustering method developed for image analysis of lung ventilation with hyperpolarized
129Xe to data acquired in a different centre with
129Xe and
3He. Results show that the current method is not readily transferable using published reference values. A different normalization method that increases the reproducibility of ventilation categorization is proposed. After optimization, the technique was applied in groups of patients with chronic obstructive pulmonary disease and cystic fibrosis. Results show significant differences of ventilation distribution indices between patient and healthy control groups.}
}
@inproceedings{ISMRM2018_4483,
annote={ISMRM2018_4483},
pages={4483},
file={ISMRM2018_4483.pdf:ISMRM2018_4483.pdf:PDF},
title={Dynamic Hyperpolarized 13C {CS}-{EPSI} of Human Prostate Cancer – Initial Experience on 17 Patients Testing Acquisition \& Quantitative Analysis Methods},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4483.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Hsin-Yu Chen and Peder E.Z. Larson and Jeremy W. Gordon and Robert A. Bok and Marcus Ferrone and Sue M. Noworolski and Mark van Criekinge and James B. Slater and Lucas Carvajal and Natalie Korn and Rahul Aggarwal and Sarah J. Nelson and Pamela N. Munster and John Kurhanewicz and Daniel B. Vigneron},
abstract={New hyperpolarized-
13C MRI instrumentation and methods enabled phase II clinical studies on 17 prostate cancer patients using 3D dynamic CS-EPSI with 0.5cm
3 spatial and 2s time resolution. New manufacturing processes for
13C-pyruvate provided more consistent polarization levels, pyruvate concentrations, radical filtrations for reliable and safe patient injections. Improved quantitative methods were designed and implemented for reproducible kinetic modeling, correction for receiver profile and peak detection, accounting for B
0 inhomogeneity and noise characteristics. These studies have shown the ability to detect high pyruvate-to-lactate conversion rates in biopsy confirmed prostate cancer.}
}
@inproceedings{ISMRM2018_4484,
annote={ISMRM2018_4484},
pages={4484},
file={ISMRM2018_4484.pdf:ISMRM2018_4484.pdf:PDF},
title={Rapid hepatic glycogen synthesis in humans using dynamic 13C {MR} spectroscopy},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4484.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jae Mo Park and Stefan Stender and Craig Malloy and Jonathan Cohen and Ralph DeBerardinis and Vlad Zaha},
abstract={The development of hyperpolarized
13C for human patients has refocused interest on radiofrequency (RF) coil design for optimal
13C sensitivity.
13C NMR spectra were acquired from the human liver using a clamshell transmit and 8-channel paddle receive array in a 3T MRI system. Following a baseline
13C liver scan for 15-min, [1-
13C]glucose was ingested and
13C MRS data were acquired for 1-3hrs. [1-
13C]glucose was observed immediately after ingestion in the stomach and evolution of [1-
13C]glycogen was monitored with < 1min temporal resolution.
13C chemical shift imaging data confirmed that the glycogen signals were localized in the liver.}
}
@inproceedings{ISMRM2018_4485,
annote={ISMRM2018_4485},
pages={4485},
file={ISMRM2018_4485.pdf:ISMRM2018_4485.pdf:PDF},
title={Acute kidney injury in diabetic rats assessed with hyperpolarized 13C {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4485.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Per Mose Nielsen and Marie Mølmer and Rikke Nørregaard and Christoffer Laustsen},
abstract={In this study we investigate the metabolic alterations, injury and fibrosis development when combining type 1 diabetes and IRI. We find the anaerobic metabolism is highly upregulated in the diabetic kidney, but this elevation is severely reduced in the reperfusion phase. The reduced injury repair capability of the diabetic kidney leads to high injury induction and fibrosis, which in turn reduces kidney function. Therefore special care should be taken to animals or patients experiencing this combination to avoid renal failure.
}
}
@inproceedings{ISMRM2018_4486,
annote={ISMRM2018_4486},
pages={4486},
file={ISMRM2018_4486.pdf:ISMRM2018_4486.pdf:PDF},
title={Restriction Spectrum Imaging-A Novel Diffusion-Based Technique for Detection and Characterization of Prostate Cancer},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4486.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ely R Felker and Leonard Marks and Fuad Elkhoury and David Lu and Daniel Margolis and Sepideh Shakeri and Pooria Khoshnoodi and Lorna Herbert and Nathan White and David Karow and Steven Raman},
abstract={We evaluated the utility of restriction spectrum imaging (RSI), a novel diffusion-based technique to detect and to characterize prostate cancer among men enrolled in a national cancer institute-funded prospective clinical trial of magnetic resonance ultrasound fusion biopsy. RSI was statistically significantly associated with clinically significant prostate cancer.}
}
@inproceedings{ISMRM2018_4487,
annote={ISMRM2018_4487},
pages={4487},
file={ISMRM2018_4487.pdf:ISMRM2018_4487.pdf:PDF},
title={Reduced {FOV} {EPI} with Blip-up Blip-down Field Correction for Prostate {DWI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4487.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Roger C Grimm and Adam T Froemming and Stephen J Riederer},
abstract={Geometric distortion in echo planar imaging spin echo images caused by a non-uniform B
0 field remains an issue in clinical imaging. The purpose of this work is to combine the reduced-field-of-view echo planar pulse sequence with a blip-up blip-down correction in prostate DWI. We show reduced geometric distortion in prostate imaging and ADC maps with little or no additional acquisition time required over current protocols.}
}
@inproceedings{ISMRM2018_4488,
annote={ISMRM2018_4488},
pages={4488},
file={ISMRM2018_4488.pdf:ISMRM2018_4488.pdf:PDF},
title={Amide proton transfer-weighted ({APTW}) {MRI} as an in vivo molecular imaging biomarker to detect prostate cancer},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4488.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Xiaoxi Chen and Lianming Wu and Weibo Chen and Jinyuan Zhou and Jianrong Xu},
abstract={We explored the capability of using the amide proton transfer-weighted MR imaging as a molecular imaging biomarker to identify prostate cancer. Results showed that both the amide proton transfer ratio (APTR) and magnetization transfer ratio (MTR) in tumors were higher than in non-tumorous regions. APT-MR imaging may have great value in clinical treatment and prognosis of prostate cancer.}
}
@inproceedings{ISMRM2018_4489,
annote={ISMRM2018_4489},
pages={4489},
file={ISMRM2018_4489.pdf:ISMRM2018_4489.pdf:PDF},
title={MultiVane Diffusion-Weighted Imaging for Multiparametric Prostate Magnetic Resonance Imaging in Men with Hip Implants: A Preliminary Report},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4489.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ali Pirasteh and Brian Johnson and Daniel N. Costa and Ananth J. Madhuranthakam and Ivan Pedrosa},
abstract={Diffusion-weighted echo-planar-imaging (DW-EPI) is the cornerstone of multiparametric MRI in evaluation of prostate cancer in the peripheral zone and can help in the detection of transitional zone tumors. However, DW-EPI suffers from significant image distortion and signal loss in men with hip arthroplasty, a population at risk for development of prostate cancer. We have implemented a DWI sequence with turbo spin-echo readout, MultiVane k-space trajectory and short-tau inversion recovery fat-suppression that provides images without appreciable distortion and promising preliminary results in evaluation of prostate cancer in men with hip implants.}
}
@inproceedings{ISMRM2018_4490,
annote={ISMRM2018_4490},
pages={4490},
file={ISMRM2018_4490.pdf:ISMRM2018_4490.pdf:PDF},
title={Intra- and Inter-scanner Variability Evaluation of {RR}-{VFA} B1+ and T1 in the Prostate at 3T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4490.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Xinran Zhong and Dapeng Liu and James Sayre and Holden H Wu and Kyunghyun Sung},
abstract={Accurate T
1 estimation is critical for quantitative prostate DCE MRI. B
1+ inhomogeneity can introduce significant error into the T
1 quantification, especially for variable flip angle method. Reference region variable flip angle (RR-VFA) method is a promising B
1+ and T
1 estimation technique, which requires no separate scans for B
1+ mapping and can reduce slice profile and position mismatch between B
1+ and T
1 maps. In this study, we investigated both intra-scanner repeatability and inter-scanner reproducibility regarding B
1+ corrected T
1 on two 3.0 T scanners to compare RR-VFA to a commercially available B
1+ estimation technique. RR-VFA showed comparable intra- and inter-scanner variability to the saturated turbo FLASH based B
1+ estimation technique.}
}
@inproceedings{ISMRM2018_4491,
annote={ISMRM2018_4491},
pages={4491},
file={ISMRM2018_4491.pdf:ISMRM2018_4491.pdf:PDF},
title={What combination of b-values is appropriate for {ADC} calculation in prostate {DWI}?},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4491.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Masamitsu Hatakenaka and Naomi Koyama and Naoya Yama and Maki Onodera and Koichi Onodera and Yurina Onuma and Ryo Taguchi and Mitsuhiro Nakanishi},
abstract={In prostate cancer, although calculating ADC with b-value combination of 50-100 and 800-1000 sec/mm
2 is recommended by PI-RADS ver. 2, ADC calculated with b-values of 0 and 1500 sec/mm
2 may be superior with respect to repeatability and correlation with cancer aggressiveness.}
}
@inproceedings{ISMRM2018_4492,
annote={ISMRM2018_4492},
pages={4492},
file={ISMRM2018_4492.pdf:ISMRM2018_4492.pdf:PDF},
title={Synthetic 3D reconstruction},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4492.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Stephen J. Riederer and Eric A. Borisch and Adam T. Froemming and Soudabeh Kargar and Akira Kawashima and Joshua D. Trzasko},
abstract={A new method is described in which slice profile in 2D multi-slice acquisition is corrected for with k-space-based processing, restoring resolution along the slice select direction. When used with multiple multi-slice acquisitions the method may allow isotropic 3D resolution. The method is described and preliminary results from phantom and prostate MRI exams are presented.}
}
@inproceedings{ISMRM2018_4493,
annote={ISMRM2018_4493},
pages={4493},
file={ISMRM2018_4493.pdf:ISMRM2018_4493.pdf:PDF},
title={Dynamic Contrast-Enhanced {MRI} of the Prostate with Single-Echo Dixon Fat Suppression},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4493.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Eric G. Stinson and Joshua D. Trzasko and Soudabeh Kargar and Eric A. Borisch and Adam T. Froemming and Akira J Kawashima and Phillip M. Young and Stephen J. Riederer},
abstract={The purpose of this work was to adapt our current clinical DCE-MRI protocol to allow for single-echo Dixon fat suppression and maintain image update times <10s. Single-echo Dixon imaging with spatial resolution that matched our current clinical protocol was performed with sub-10s update times and near-optimal Dixon SNR by increasing the readout bandwidth from ±62.5 to ±83.3 kHz. Additionally, pharmacokinetic modelling results look similar to those produced from the standard DCE-MRI protocol. DCE-MRI of the prostate with single-echo Dixon fat suppression provides high spatial and temporal resolution dynamic imaging of contrast uptake without the presence of confounding fat signal.}
}
@inproceedings{ISMRM2018_4494,
annote={ISMRM2018_4494},
pages={4494},
file={ISMRM2018_4494.pdf:ISMRM2018_4494.pdf:PDF},
title={The repeatability of fully automated atlas-based prostate segmentation on T2-weighted {MR} images},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4494.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Mohammed R S Sunoqrot and Daniel C Billdal and Kirsten M Selnæs and Mattijs Elschot and Tone F Bathen},
abstract={Computer-aided diagnosis (CADx) systems have been proposed to overcome the limitations of the radiological reading of multiparametric MRI. Fully automated segmentation of the prostate is a crucial step of CADx systems, which can be successfully performed by atlas-based segmentation of T2-weighted (T2W) MR images. For applications like treatment monitoring and active surveillance, the repeatability of automated segmentation method is highly important. In this work, we investigated the repeatability of several fully automated atlas-based prostate segmentation methods. We found that the repeatability of the investigated methods is excellent, which is promising for the further development of CADx systems following patients with multiple measurements over time.}
}
@inproceedings{ISMRM2018_4495,
annote={ISMRM2018_4495},
pages={4495},
file={ISMRM2018_4495.pdf:ISMRM2018_4495.pdf:PDF},
title={Multi-echo T2 modelling to predict {PIRADS} 2.0 score},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4495.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={William Devine and Francesco Giganti and Edward Johnston and Eleftheria Panagiotaki and Shonit Punwani and Daniel C. Alexander and David Atkinson},
abstract={To investigate if Luminal Water Imaging (LWI), which models multi-compartment T2 decay, can predict the PIRADS 2.0 score of a region of interest (ROI). 52 patients were scanned using both standard mp-MRI and a 32-echo T2 sequence, ROIs were placed in areas of suspected lesion and suspected benign tissue and then these ROIs were each given a PIRADS 2.0 score. The results show that LWI can predict PIRADS 2.0 score as well as the Apparent Diffusion Coefficient (ADC).}
}
@inproceedings{ISMRM2018_4496,
annote={ISMRM2018_4496},
pages={4496},
file={ISMRM2018_4496.pdf:ISMRM2018_4496.pdf:PDF},
title={Two compartment fitting for Luminal Water Imaging: multi-echo T2 in Prostate Cancer},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4496.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={William Devine and Francesco Giganti and Edward Johnston and Eleftheria Panagiotaki and Shonit Punwani and Daniel C. Alexander and David Atkinson},
abstract={This work aims both to show that using a constrained fitting method for Luminal Water Imaging with fewer echoes produces accurate parameter estimates and that this fitting method is feasible for detecting and grading Prostate Cancer. Simulated signals were produced and the mean LWF across multiple iterations was calculated for two models.Then19 patients were imaged and the images were contoured in both cancerous and benign regions.The simulation showed that the proposed constrained method is accurate and the in-vivo imaging reinforced the idea that multi-echo T2 modelling shows promise in detecting and grading PCa.}
}
@inproceedings{ISMRM2018_4497,
annote={ISMRM2018_4497},
pages={4497},
file={ISMRM2018_4497.pdf:ISMRM2018_4497.pdf:PDF},
title={Accelerated 3D T2 mapping with dictionary-based matching for prostate imaging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4497.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Elisa Roccia and Rohini Vidya Shankar and Radhouene Neji and Gastao Cruz and Rene Botnar and Claudia Prieto and Vicky Goh and Isabel Dregely},
abstract={Quantitative T
2 mapping has potential for prostate cancer discrimination. However, current methods are typically 2D, require long scan times and may lead to inaccuracies if using an oversimplified exponential model. We propose rapid 3D T
2 mapping based on accelerated 3D multi shot T
2-prepared bSSFP acquisition combined with dictionary-based matching. The dictionary of signals was generated using a simulation framework taking into account the specifics of the acquisition and was then matched to the acquired images to retrieve T
2 values. The proposed approach was tested in healthy subjects enabling the acquisition of 3D T
2 mapping of the whole prostate in 4min.}
}
@inproceedings{ISMRM2018_4498,
annote={ISMRM2018_4498},
pages={4498},
file={ISMRM2018_4498.pdf:ISMRM2018_4498.pdf:PDF},
title={High-resolution 3D T1 mapping of the prostate with an efficient inversion-recovery radial {FLASH} pulse sequence},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4498.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Zhitao Li and Ali Bilgin and Kevin Johnson and Hina Arif and Diego R Martin and Maria I Altbach},
abstract={A 3D IR radial FLASH technique and a model-based iterative algorithm for the reconstruction of undersampled data are demonstrated for efficient high-resolution T
1 mapping of the prostate. The method is insensitive to B
1 inhomogeneity and provides full coverage of the prostate volume within the time constrains of a clinical examination.}
}
@inproceedings{ISMRM2018_4499,
annote={ISMRM2018_4499},
pages={4499},
file={ISMRM2018_4499.pdf:ISMRM2018_4499.pdf:PDF},
title={The Medical College of Wisconsin 39 ({MCW}39): A Magnetic Resonance Image Template of the Prostate to Facilitate Group Analysis},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4499.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Sean D McGarry and Matthew Budde and Sarah L Hurrell and Kenneth A Ickzowski and Michael Griffin and Petar Duvnjak and Kenneth Jacobsohn and William Hall and Mark Hohenwalter and Andrew Nencka and Peter LaViolette},
abstract={The Medical College of Wisconsin 39 (MCW39) template provides a common space for the analysis of prostate cancer images. The template was generated through iterative spatial registration of T2-weighted images starting with manually drawn contours as a reference point. Expert annotations of Gleason Grade were transformed into the template space and maps of tumor probabilities reveal the spatial localization of cancer across the cohort for each grade.}
}
@inproceedings{ISMRM2018_4500,
annote={ISMRM2018_4500},
pages={4500},
file={ISMRM2018_4500.pdf:ISMRM2018_4500.pdf:PDF},
title={Effect of Intravascular Contrast Agent on Diffusion and Perfusion Fraction Coefficients in the Peripheral Zone and Prostate Cancer},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4500.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yousef Mazaheri and Andreas M Hötker and Amita Shukla-Dave and Oguz Akin and Hedvig Hricak},
abstract={We present a systematic approach to characterize differences in pre- and post-contrast diffusion and perfusion parameters. In addition to measuring ADC values before and after contrast injection, we extended the mono-exponential model to incorporate the contribution of pseudo-perfusion to the signal intensity and evaluated the impact of contrast injection on molecular diffusion (D) and perfusion fraction (f). We find in PCa, the coefficient D, like ADC, was significantly lower on post-contrast as compared to pre-contrast DWI, while the perfusion fraction coefficient was significantly higher on post-contrast acquisitions. In PZ, ADC and D did not differ significantly between post- and pre-contrast acquisitions, but f was significantly higher after contrast injection.}
}
@inproceedings{ISMRM2018_4501,
annote={ISMRM2018_4501},
pages={4501},
file={ISMRM2018_4501.pdf:ISMRM2018_4501.pdf:PDF},
title={Synthetic {MRI} of the Prostate using {MAG}iC: Clinical Feasibility and Preliminary Results},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4501.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yousef Mazaheri and Maggie Fung and Duane A Nicholson and Amita Shukla-Dave and Hedvig Hricak and Oguz Akin},
abstract={In this study, we evaluated a 2D combined simultaneous multi-contrast acquisition sequence, referred to MAGiC, which allows simultaneously obtaining images to generate, T1, T2, PD, STIR map with acceptable scan duration within a single acquisition. High quality T1- and T2-w images were synthetically generated using mathematical signal models. Prostate images obtained from patients and volunteers showed that T1 and T2 measured by MAGiC were within 16\% of the values measured using conventional mapping techniques with reasonable spatial resolution.}
}
@inproceedings{ISMRM2018_4502,
annote={ISMRM2018_4502},
pages={4502},
file={ISMRM2018_4502.pdf:ISMRM2018_4502.pdf:PDF},
title={{MR} Fingerprinting and {ADC} Mapping for Characterization of Lesions in Transitional Zone of Prostate},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4502.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ananya Panda and Yun Jiang and Seunghee Margevicius and Wei-Ching Lo and Mark Schluchter and Chaitra Badve and Mark Griswold and Lee Ponsky and Vikas Gulani},
abstract={This study presents utility of MRF derived relaxometry and ADC mapping for differentiating transition zone prostate cancers from non-cancerous lesions. Based on targeted biopsy correlation, T
1, T
2, ADC were compared between cancer, prostatitis and normal transition zone (NTZ). Mean T
1, T
2 and ADC were significantly different between cancer and NTZ. Mean T
1 and ADC were significantly different between prostate cancer and prostatitis. While ADC had an AUC of 0.821 for differentiating cancer and prostatitis, a combination of T
1 and T
2 mapping had an AUC of 0.875. Thus MRF can add significant value to ADC mapping in characterization of TZ lesions.}
}
@inproceedings{ISMRM2018_4503,
annote={ISMRM2018_4503},
pages={4503},
file={ISMRM2018_4503.pdf:ISMRM2018_4503.pdf:PDF},
title={Multicenter repeatability and reproducibility of {MR} Fingerprinting},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4503.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Wei-Ching Lo and Yun Jiang and Leonardo Kayat Bittencourt and Junichi Tokuda and Ravi Seethamraju and Clare Tempany-Afdhal and Ananya Panda and Katherine Wright and Mark Griswold and Nicole Seiberlich and Vikas Gulani},
abstract={MRF enables rapid collection of multiple tissue properties simultaneously. For clinical applications, the T
1 and T
2 values must be repeatable over time and on different MRI scanners so that any observed relaxivity difference can be assumed to be due to differences in physiology rather than scanner instability, differences in pulse sequence or map reconstruction implementations. This study evaluated multicenter repeatability and reproducibility of T
1 and T
2 estimates of MRF in the ISMRM/NIST MRI system phantom and normal prostate regions in patients. The intra-scanner variation was less than 2\% for MRF T
1 and 4.7\% for T
2 within the biological range.}
}
@inproceedings{ISMRM2018_4504,
annote={ISMRM2018_4504},
pages={4504},
file={ISMRM2018_4504.pdf:ISMRM2018_4504.pdf:PDF},
title={Histogram Analysis of monoexponential {DWI}, biexponential {IVIM} model and {PI}-{RADS} V2 for the Differentiation of Prostate Cancer from {BPH} in the Transition zone},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4504.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={jie bao and ximing wang and zhongshuai zhang and su hu and xiaoxia ping and chunhong hu},
abstract={In this study, we propose to evaluate histogram analysis of ADC derived by traditional DWI model, diffusion related parameters calculated by using intravoxel incoherent motion (IVIM) model and PI-RADS V2 for the detection of the prostate cancer (PCa) in the transition zone (TZ). Our results show that the highest classification accuracy was achieved by the mean ADC (0.841) and mean D (0.809, acquired by the IVIM model). Our findings suggest that Monoexponential DWI and biexponential IVIM model could potentially improve the accuracy of the pathological grading of prostate cancer in TZ.}
}
@inproceedings{ISMRM2018_4505,
annote={ISMRM2018_4505},
pages={4505},
file={ISMRM2018_4505.pdf:ISMRM2018_4505.pdf:PDF},
title={A study on Compressed {SENSE}({CSENSE}) in prostate T2map at 3T.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4505.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={seiichiro noda and nobuyuki toyonari and yukari horino and kazuhiro katahira and masami yoneyama and yasutomo katsumata},
abstract={We study on Compressed SENSE in prostate T2map at 3T The imaging sequence used spin echo type multi echo. In case of SENSE, increase Factor resulted in an artifact peculiar to parallel imaging and an error occurred in T2 value measurement of the prostate. However, in the case of CSENSE, artifacts were reduced and T2 value measurement was also possible. Prostate T2map can reduce imaging time using CSENSE.}
}
@inproceedings{ISMRM2018_4506,
annote={ISMRM2018_4506},
pages={4506},
file={ISMRM2018_4506.pdf:ISMRM2018_4506.pdf:PDF},
title={Characterization of Human Prostate Cancer Using Tissue Sodium Concentration Measured from Sodium {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4506.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Nolan Broeke and Justin Peterson and Adam Farag and Aaron Ward and Stephen Pautler and Joseph Chin and Glenn Bauman and Robert Bartha and Timothy Scholl},
abstract={Over-treatment of prostate cancer is a significant problem in men’s healthcare. Development of non-invasive imaging tools for improved identification of prostate lesions can reduce over-treatment. We have built custom sodium MRI hardware to image and quantify tissue sodium concentration (TSC) in the human prostate. Sodium and multi-parametric MR images are co-registered to Gleason-graded post-prostatectomy histology, the current gold standard for prostate cancer lesion characterization. Our data shows a statistically significant, positive correlation of TSC with Gleason score. These data suggest that TSC measured by sodium MRI, in addition to multi-parametric MRI has utility for non-invasive characterization of prostate cancer.}
}
@inproceedings{ISMRM2018_4507,
annote={ISMRM2018_4507},
pages={4507},
file={ISMRM2018_4507.pdf:ISMRM2018_4507.pdf:PDF},
title={Quantitative T2 in ex vivo prostate: relationship to microstructure and {VERDICT} {MRI} parameters},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4507.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Colleen Bailey and Bernard Siow and Roger M Bourne and Edward William Johnston and Mrishta Brizmohun Appayya and Hayley Pye and Susan Heavey and Thomy Mertzanidou and Hayley Whitaker and Alex Freeman and Dominic Patel and Greg L Shaw and Ashwin Sridhar and David J Hawkes and Shonit Punwani and Daniel C Alexander and Eleftheria Panagiotaki},
abstract={Quantitative T2 and VERDICT diffusion MRI data were acquired in ex vivo prostate specimens, using a patient-specific mold to allow comparison with registered prostate images. Analysis indicated differences from in vivo T2 spectra, such as a single T2 component dominating the spectrum in most regions, but with longer T2 values where there was generally more lumen space. A small component with T2 of 10-20 ms was observed in some cancerous regions. The geometric mean of the T2 spectrum was inversely correlated with the intracellular fraction parameter from VERDICT and correlated with the diffusion coefficients of the Tensor component modelling the extracellular space.}
}
@inproceedings{ISMRM2018_4508,
annote={ISMRM2018_4508},
pages={4508},
file={ISMRM2018_4508.pdf:ISMRM2018_4508.pdf:PDF},
title={The diagnostic potential and repeatability of Relative Enhanced Diffusivity ({RED}) as a biomarker for prostate cancer},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4508.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Daniel Chen Billdal and Mohammed R S Sunoqrot and Kirsten Margrete Selnæs and Peter Thomas While and Brage Krüger-Stokke and Helena Bertilsson and Tone Frost Bathen and Mattijs Elschot},
abstract={Relative Enhanced Diffusivity (RED) expresses the relative change in ADC between lower and higher b-value regimes. The purpose of this study was to investigate the diagnostic potential and repeatability of RED as a biomarker for prostate cancer (PCa). Ten (10) healthy volunteers and 28 high-risk patients diagnosed with PCa underwent diffusion-weighted MRI. For the healthy volunteers, the repeatability of RED was good to acceptable. For the patients, RED was able to discriminate tumors from healthy tissue in the peripheral zone using either b=50 or b=400 mm/s
2 as the intermediate b-value (p < 0.001).}
}
@inproceedings{ISMRM2018_4509,
annote={ISMRM2018_4509},
pages={4509},
file={ISMRM2018_4509.pdf:ISMRM2018_4509.pdf:PDF},
title={Evaluation of Fitting Uncertainties and Errors for Dispersion-Based Imaging of Prostate {DCE}-{MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4509.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={KyungHyun Sung},
abstract={The MR dispersion imaging (MRDI) has shown great promise in prostate DCE-MRI, but there still exist practical limitations due to the complex model fitting. We evaluate fitting uncertainties and errors in parameter estimation for MRDI and recently proposed modified MRDI (mMRDI). We use the time-concentration curves derived from 94 prostate cancer lesions for fitting uncertainties and errors and assess the ability to delineate between cancerous and normal prostate tissues.
}
}
@inproceedings{ISMRM2018_4510,
annote={ISMRM2018_4510},
pages={4510},
file={ISMRM2018_4510.pdf:ISMRM2018_4510.pdf:PDF},
title={Simultaneous f{MRI} and electrophysiology: measuring local field potential, multi-unit and single unit activity},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4510.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Brittany M Katz and Tzu-Hao Chao and Mike Sorenson and You-Yin Chen and Yen-Yu Ian Shih and SungHo Lee},
abstract={The use of hemodynamic signals as a surrogate measure of neuronal activity presents a major challenge to any straightforward interpretation of fMRI data. In recognition of this caveat, this study describes a polyimide-based MR-compatible microelectrode array with a MR-compatibleheadstagepreamplifier and demonstrates the feasibility in vivo for recordingof BOLD, LFP, MUA and single-unit activity simultaneously.}
}
@inproceedings{ISMRM2018_4511,
annote={ISMRM2018_4511},
pages={4511},
file={ISMRM2018_4511.pdf:ISMRM2018_4511.pdf:PDF},
title={Neuropharmacological f{MRI} of {MDMA} – A Novel, Multimodal Analytical Approach Informed by {PET}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4511.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ottavia Dipasquale and Pierluigi Selvaggi and Anthony Gabay and Mattia Veronese and Steve CR Williams and Federico Turkheimer and Mitul Mehta},
abstract={This study evaluates the degree to which resting-state fMRI (rfMRI) response indexes the action at drug target sites by testing whether haemodynamic response to MDMA mirrors receptor 5-HT density profiles measured with PET. We weighted the rfMRI BOLD signal using a high-resolution in vivo atlas of the serotonin system. Results show that an altered haemodynamic response to MDMA is detectable only in the maps related to MDMA serotonin targets. This study provides new evidence that rfMRI haemodynamic response to MDMA reflects the known binding profile of the drug and set the basis for a biologically-informed rfMRI analysis in drug challenges.}
}
@inproceedings{ISMRM2018_4512,
annote={ISMRM2018_4512},
pages={4512},
file={ISMRM2018_4512.pdf:ISMRM2018_4512.pdf:PDF},
title={{BOLD} Hemodynamic Response Function Varies as a Function of Both Brain State and Brain Region},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4512.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Russell Butler and Guillaume Gilbert and Maxime Descoteaux and Pierre-Michel Bernier and Kevin Whittingstall},
abstract={The BOLD signal is linked to neural activity through the canonical hemodynamic response function (HRF), often assumed to be static across both brain area and brain state. We employed simultaneous EEG-FMRI recordings to investigate the hemodynamic response to neural activity in the alpha, beta and gamma frequency bands. We find that the shape of the HRF depends on both brain region and brain state. Default mode network (DMN) BOLD signals are linked to alpha synchronization, while occipital BOLD signals are linked to alpha/beta desynchronization and gamma synchronization. Connectivity estimates assuming a canonical HRF may be biased by HRF differences across region and state.}
}
@inproceedings{ISMRM2018_4513,
annote={ISMRM2018_4513},
pages={4513},
file={ISMRM2018_4513.pdf:ISMRM2018_4513.pdf:PDF},
title={Automatic Electrodes Detection during simultaneous {EEG}/f{MRI} acquisition},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4513.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Mathis Fleury and Pierre Maurel and Marsel Mano and Elise Bannier and Christian Barillot},
abstract={Simultaneous EEG/fMRI acquisition allows to measure brain activity at high spatial-temporal resolution. The localisation of EEG sources depends on several parameters including the position of the electrodes on the scalp. The position of the MR electrodes during its acquisitions is obtained with the use of the UTE sequence allowing their visualisation. The retrieval of the electrodes consists in obtaining the volume where the electrodes are located by applying a sphere detection algorithm. We detect around 90\% of electrodes for each subject and our UTE-based electrode detection showed an average position error of 3.7mm for all subjects.}
}
@inproceedings{ISMRM2018_4514,
annote={ISMRM2018_4514},
pages={4514},
file={ISMRM2018_4514.pdf:ISMRM2018_4514.pdf:PDF},
title={Assessment of neural correlates of cortical communication of Alpha/Gamma bands between frontal and parietal-occipital regions in Situational Awareness task as well as in resting-state: An {EEG} informed f{MRI} approach},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4514.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ardaman Kaur and Vijayakumar C and Swati Agrawal and Subash Khushu and Rishu Chaujar and Suresh Sharma},
abstract={Cross frequency coupling of Alpha/Gamma oscillations between frontal and parietal-occipital cortex coordinates neuronal communication at higher frequency which often correlates with higher-order cognitions. The dynamics of cross frequency coupling and neuronal communication is often modulated by higher-order cognition tasks while comparing resting-state. The neural correlates and modulation of these cortical communication caused by reciprocal relationship of alpha/gamma band between frontal and parietal-occipital regions are poorly understood. Hence in this study, cortical functional correlation of alpha/gamma oscillation between frontal and parietal-occipital region for higher-order cognitive task such as Situational Awareness is assessed and its modulation from resting-state has been explored.}
}
@inproceedings{ISMRM2018_4515,
annote={ISMRM2018_4515},
pages={4515},
file={ISMRM2018_4515.pdf:ISMRM2018_4515.pdf:PDF},
title={Does Pre-task Resting state Absolute Alpha ({PRAA}) power and its Frontal Asymmetry Index ({FAI}) predict outcome of Situational Awareness task? Assessment through {EEG} informed f{MRI} approach.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4515.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ardaman Kaur and Vijayakumar C and Swati Agrawal and Subash Khushu and Rishu Chaujar and Suresh Sharma},
abstract={One of the established hypotheses is that alpha-oscillation inhibits irrelevant stimulus processing during task, but correlates positively with emotional stability of individual in absence of predefined task. However, role of Pre-task Resting state Absolute Alpha rhythm (PRAA) and its frontal hemispheric difference estimated by Frontal Asymmetry Index (FAI) in predicting the outcome of individual’s performance in higher-order cognitive task is poorly understood. Thus, in this study, correlation of PRAA and FAI with behavioral parameter pertaining to Situational Awareness (SA) task was studied. Further, to substantiate the emotional connectivity of PRAA and FAI index, their neural correlates in task-fMRI were estimated.}
}
@inproceedings{ISMRM2018_4516,
annote={ISMRM2018_4516},
pages={4516},
file={ISMRM2018_4516.pdf:ISMRM2018_4516.pdf:PDF},
title={Estimation of simultaneous {BOLD} and {FDG} metabolism activation using a coherent {ICA} method},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4516.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Shenpeng Li and Francesco Sforazzini and Sharna D. Jamadar and Philllip G.D. Ward and Jakub Baran and Malin Premaratne and Gary Egan and Zhaolin Chen},
abstract={This abstract proposes a new joint fMRI and functional FDG-PET (fPET) ICA analysis method, coherent ICA, based on the simultaneously acquired dual-modality imaging data. It applies ICA on the spatiotemporal data sets from both modalities to obtain coherent activation maps and preserve their correspondent temporal information, which is not retained by existing methods. The preserved temporal information can potentially be used to investigate the interaction between BOLD signal and other metabolism change measured by fPET.}
}
@inproceedings{ISMRM2018_4517,
annote={ISMRM2018_4517},
pages={4517},
file={ISMRM2018_4517.pdf:ISMRM2018_4517.pdf:PDF},
title={Delayed f{MRI} timing in the human auditory cortex in lexical processing is correlated with increased {EEG} power in beta band},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4517.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Hsin-Ju Lee and Hui-Chuan Chang and Ying-Hua Chu and Wen-Jui Kuo and Fa-Hsuan Lin},
abstract={Using fast fMRI (whole-brain 10 Hz sampling), we revealed the left hemisphere’s BOLD signal is more delayed by 500 ms when engaging a lexical discrimination task than a non-lexical discrimination task. EEG study on the same subjects suggested such BOLD signal delay is related to the oscillatory power in the beta band.}
}
@inproceedings{ISMRM2018_4518,
annote={ISMRM2018_4518},
pages={4518},
file={ISMRM2018_4518.pdf:ISMRM2018_4518.pdf:PDF},
title={Level of {TMS}-evoked activation in anterior cingulate cortex depends on timing of {TMS} delivery relative to frontal alpha phase},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4518.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Golbarg T. Saber and James R. McIntosh and Jayce Doose and Josef Faller and Yida Lin and Hunter Moss and Robin I. Goldman and Mark S. George and Paul Sajda and Truman R. Brown},
abstract={To test whether the level of activation of the anterior cingulate cortex (ACC) following a TMS pulse delivered to the dorsolateral prefrontal cortex depends on precise timing of its delivery relative to an individual’s alpha rhythm, we developed an integrated EEG-fMRI-TMS instrument capable of acquiring simultaneous EEG-fMRI while delivering TMS pulses in the scanner. We found a statistically significant effect of BOLD signal change in ACC dependent on individual subject frontal alpha phase just prior to TMS delivery. Specifically, TMS-evoked BOLD response in the ACC increased when TMS pulse was synchronized to the rising slope of the frontal alpha oscillation.}
}
@inproceedings{ISMRM2018_4519,
annote={ISMRM2018_4519},
pages={4519},
file={ISMRM2018_4519.pdf:ISMRM2018_4519.pdf:PDF},
title={Improving Sensitivity of Task-f{MRI} Signals by Use of Time Delayed Systemic Regressors: A Comparison of Probe Regressors from Peripheral {NIRS} Recordings and {BOLD}-f{MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4519.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Sinem Burcu Erdogan and Yunjie Tong and Lia Maria Hocke and Kimberly P. Lindsay (Dec.) and Blaise DeBonneval Frederick},
abstract={A fundamental problem with fMRI measurements is the strong presence of low frequency systemic physiological noise (<0.15 Hz), which significantly corrupts detection power for hemodynamic variations caused by task induced neuronal activation. In this study, we propose a novel noise removal strategy for task-fMRI studies by taking into consideration a relatively new established property of systemic low frequency oscillations (sLFOs): their dynamic propagation within cerebral vasculature causing voxel-specific arrival delays. We compare the performance of dynamic noise modelling regressors obtained from i) BOLD data and ii) a fingertip HBO signal of non-neuronal origin concurrently recorded with near infrared spectroscopy (NIRS).}
}
@inproceedings{ISMRM2018_4520,
annote={ISMRM2018_4520},
pages={4520},
file={ISMRM2018_4520.pdf:ISMRM2018_4520.pdf:PDF},
title={Multimodal Correlation and Connectivity Analysis on Simultaneously Recorded {MR}-{PET} data},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4520.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ravichandran Rajkumar and Elena Rota Kops and Jürgen Scheins and Lutz Tellmann and Christoph Lerche and Karl-Josef Langen and Hans Herzog and N. Jon Shah and Irene Neuner},
abstract={On a simultaneously recorded resting state MR-PET data, the functional connectivity metrics (namely ReHo, fALFF and DC) from fMRI and the glucose metabolism from FDG – PET are calculated and correlated in the default mode network (DMN) regions of the brain. Results shows high connectivity of the DMN hubs is coupled with a high glucose consumption. Further investigations in patients are necessary to explore the potential of simultaneous imaging as a biomarker for disease staging, treatment response and monitoring}
}
@inproceedings{ISMRM2018_4521,
annote={ISMRM2018_4521},
pages={4521},
file={ISMRM2018_4521.pdf:ISMRM2018_4521.pdf:PDF},
title={Improved cardioballistic artifact waveform for artifact correction with direct cardiac cycle detection from {EEG}-f{MRI} data},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4521.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Chung-Ki Wong and Qingfei Luo and Vadim Zotev and Raquel Phillips and Kam Wai Clifford Chan and Jerzy Bodurka},
abstract={In simultaneous EEG-fMRI, cardioballistic (BCG) artifact removal algorithms require the detection of artifact occurrence time to form subtraction template for artifact correction. The artifact occurrence time can be estimated by an average delay following the R-peak of electrocardiogram (ECG) recording, or directly measured from the BCG component in the EEG data. Here we compared the BCG artifact waveform evaluated by artifact cycles measured from the BCG and ECG data. We found that direct BCG cycle detection from EEG data provides better BCG waveform for the artifact correction and eliminates the need for independent ECG recording.}
}
@inproceedings{ISMRM2018_4522,
annote={ISMRM2018_4522},
pages={4522},
file={ISMRM2018_4522.pdf:ISMRM2018_4522.pdf:PDF},
title={Correlation between the Scaling Exponent of the Power Spectral Density Function of Local Field Potentials and the {BOLD} signal},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4522.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Xiaodi Zhang and Wen-Ju Pan and Shella Keilholz},
abstract={In this abstract we proposed a new method to assess whether changes in the power spectral density (PSD) function of local field potential (LFP) are correlated with the BOLD signal using a single parameter that describes the relative distribution of activity across frequencies (the power scale exponent). The correlation maps obtained using the scaling exponent exhibit strong, localized correlations at the locations near the electrodes in some scans, similar to those obtained from the LFP power time course method.}
}
@inproceedings{ISMRM2018_4523,
annote={ISMRM2018_4523},
pages={4523},
file={ISMRM2018_4523.pdf:ISMRM2018_4523.pdf:PDF},
title={Silent Simultaneous {EEG}-f{MRI} using Looping-Star.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4523.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Beatriz Dionisio and Michael Czisch and Victor Spoormaker and Philipp Saemann and Darius Burschka and Marion Menzel and Axel Haase and Florian Wiesinger and Ana Beatriz Solana},
abstract={This work presents a novel technique for silent simultaneous EEG-fMRI, combined with a slow gradient switching fMRI method called Looping-Star. In comparison to the conventional setup with Gradient-Echo EPI, the silent technique improves the EEG quality while maintains fMRI quality characteristics. The inaudible scanning offers higher sensitivity to auditory stimuli, resulting in enhanced evoked response potentials (ERPs).}
}
@inproceedings{ISMRM2018_4524,
annote={ISMRM2018_4524},
pages={4524},
file={ISMRM2018_4524.pdf:ISMRM2018_4524.pdf:PDF},
title={{EEG}/{MEG} Source Imaging using f{MRI} Informed Time-variant Constraints},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4524.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jing Xu and Jingwei Sheng and Tianyi Qian and Zihui Su and Jia-Hong Gao},
abstract={The accuracy of fMRI-constrained EEG/MEG source imaging may be degraded by potential spatial mismatches between the locations of fMRI activation and electrical source activities. To address this problem, we propose a novel fMRI informed time-variant constraint (FITC) method. Simulations were performed to compare the source estimates produced by L2-minimum norm estimation (MNE), fMRI-weighted minimum norm estimation (fMNE), FITC and depth-weighted FITC (wFITC) algorithms with various spatial mismatch conditions. In conclusion, the proposed FITC method is able to better resolve the spatial mismatch problems encountered in fMRI-constrained EEG/MEG source imaging.}
}
@inproceedings{ISMRM2018_4525,
annote={ISMRM2018_4525},
pages={4525},
file={ISMRM2018_4525.pdf:ISMRM2018_4525.pdf:PDF},
title={Spatiotemporal coupling between dopamine neurotransmitter release and {BOLD} signaling in the ventral striatum},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4525.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={nan li and Lili Cai and Alan P Jasanoff},
abstract={As the most commonly used fMRI technique for human brain study, BOLD functional MRI is not detecting neuronal activity directly and the mechanism is not clear. Here we demonstrate, for the first time, to directly explore the relationship between the regional DA neurotransmitter release and the co-localized BOLD signaling in vivo by combing molecular – level dopamine-sensitive MRI technique and BOLD fMRI. Our result demonstrated nonlinear and spatially‐heterogeneity relationships between neurotransmitter activity and the hemodynamic responses in the same region. We expect the result will facilitate a better understanding and explanation of human fMRI results.}
}
@inproceedings{ISMRM2018_4526,
annote={ISMRM2018_4526},
pages={4526},
file={ISMRM2018_4526.pdf:ISMRM2018_4526.pdf:PDF},
title={Hand-related Auditory and Visual Stimulation on {BOLD} f{MRI} and {EEG} in Children with Autism Spectrum Disorder},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4526.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Shijun Li and Yi Wang and Lin Ma},
abstract={By using Blood oxygen level dependent (BOLD) magnetic resonance imaging (MRI) method with hand-related pictures and sound stimulating on Autism Spectrum Disorder (ASD) children, the difference was found in the border of temporal lobe and occipital lobe in ASD and NC contrast. And these findings may help guide the precise intervention or treatment in ASD.}
}
@inproceedings{ISMRM2018_4527,
annote={ISMRM2018_4527},
pages={4527},
file={ISMRM2018_4527.pdf:ISMRM2018_4527.pdf:PDF},
title={Hyperacusis and hearing loss induce increased causal flow from auditory cortex to mesolimbic pathway after long-term dynamic functional remodeling},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4527.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ying Luan},
abstract={Hyperacusis is a common hearing disorder with reduced loudness perception tolerance and hypersensitivity to ordinary environmental sounds, often co-exist with hearing loss and tinnitus. Hyperacusis and hearing loss are often associated with accelerated cognition decline and affection disorders.This study aimed to utilize behavioral and fMRI techniques in combination with Granger causality analysis to investigate dynamic functional connectome remodeling in hyperacusis and hearing loss rat models which could be the neural mechanisms of cognition and emotion deficits .}
}
@inproceedings{ISMRM2018_4528,
annote={ISMRM2018_4528},
pages={4528},
file={ISMRM2018_4528.pdf:ISMRM2018_4528.pdf:PDF},
title={{BOLD}-{MRI} imaging for the evaluation of hepatic warm ischemia-reperfusion injury and the effect of Lipo-{PGE}1 intervention in rabbit models},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4528.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Qian Ji and Jingyao Li and Tianyi Qian and Jinxia Zhu},
abstract={This study aimed to determine the feasibility of using BOLD MRI to diagnose liver ischemia-reperfusion injury and the effect of Lipo-PGE1 intervention in rabbits. Seven groups of rabbits with liver ischemia-reperfusion injury induced using various means were examined using a 3T clinical MR scanner and followed by biochemical and histopathological analysis. The R2* values were significantly positively correlated with alanine aminotransferase, aspartate aminotransferase and lactate dehydrogenase. These results suggest that BOLD MRI is suitable for quantitatively assessing the degree of ischemia and the effect of Lipo-PGE1 in rabbits.}
}
@inproceedings{ISMRM2018_4529,
annote={ISMRM2018_4529},
pages={4529},
file={ISMRM2018_4529.pdf:ISMRM2018_4529.pdf:PDF},
title={Comparison of f{MRI} and f{NIRS} mapping and systemic influences using a specifically designed multimodal probe for ultrahigh-resolution mapping},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4529.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Lia Maria Hocke and Kenroy R Cayetano and Yunjie Tong and Blaise deB Frederick},
abstract={fMRI is the gold standard of human functional brain imaging, although functional near-infrared spectroscopy (fNIRS) is easier to administer and lower in cost. Therefore studies have tried to compare the two techniques. However results have been variable, partly due to only rough spatial correspondence between fMRI and fNIRS and systemic physiological noise influences. In the current study we use a previously described multimodal fNIRS/fMRI probe with optodes directly integrated into the coil structure. We characterize the spatial and temporal overlap between task-evoked fMRI and fNIRS signal, as well as their systemic physiological influences with high spatial and temporal correspondence.}
}
@inproceedings{ISMRM2018_4530,
annote={ISMRM2018_4530},
pages={4530},
file={ISMRM2018_4530.pdf:ISMRM2018_4530.pdf:PDF},
title={Alterations of functional connectivity in the rat brain induced by {NMDA} receptor antagonists Traxoprodil and Lanicemine},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4530.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Robert Becker and Natalia Gass and Lothar Kußmaul and David Schnell and Cornelia Dorner-Ciossek and Wolfgang Weber-Fahr and Alexander Sartorius},
abstract={Since ketamine has been found to act antidepressant, NMDA receptor antagonists are investigated regarding their potential use in therapy of depression. In this study we investigated the effects of traxoprodil and lanicemine on resting state functional connectivity in the rat brain. Both drugs significantly altered hippocampal-prefrontal (Hc-PFC) connectivity with more pronounced effect of traxoprodil. Interestingly the pronounced effects on intra PFC connectivity found in a previous ketamine study could not be observed. Traxoprodil also reduced whole brain network segregation. HC-PFC connectivity appears to be a promising target for further investigation of NMDA receptor antagonists and their antidepressant effects.}
}
@inproceedings{ISMRM2018_4531,
annote={ISMRM2018_4531},
pages={4531},
file={ISMRM2018_4531.pdf:ISMRM2018_4531.pdf:PDF},
title={Optimising simultaneous {EEG}-f{MRI} data acquisition: artefact minimisation},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4531.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Christopher Sabin and David Carmichael and Amy McDowell},
abstract={Simultaneous EEG-fMRI benefits from the two modalities’ high-temporal and high-spatial resolutions. However, the MRI environment can cause artefacts in EEG signal, as movement of the EEG equipment causes artefactual voltages. This work investigated configurations of the EEG equipment (in-bore ‘sled’ v ‘cantilever’) in terms of their artefact reduction; in particular relating to vibrations from the scanner’s helium cooling pump. We found vibration artefacts were broadly similar between the two configurations but the sled significantly reduced raw gradient artefact while increasing helium pump artefact. The helium pump needs to be turned off for highest recording quality in either configuration.
}
}
@inproceedings{ISMRM2018_4532,
annote={ISMRM2018_4532},
pages={4532},
file={ISMRM2018_4532.pdf:ISMRM2018_4532.pdf:PDF},
title={Brain Structural Impairment Associated with Aberrant Functional Responses to the Valsalva Maneuver in Heart Failure},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4532.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Xiaopeng Song and Bhaswati Roy and Sadhana Singh and Ashish Sahib and Cristina Caberera-Mino and Gregg C. Fonarow and Mary A. Woo and Rajesh Kumar},
abstract={Heart failure (HF) patients show inability to regulate heart rate and blood pressure in response to autonomic challenge. Using BOLD-fMRI and DTI-MD procedures, we found that functional MRI responses during the Valsalva maneuver in cerebellum and insular are delayed or reduced in amplitude and comparable areas showed structural injury in HF subjects. These findings show that impaired functional responses during the Valsalva maneuver have brain structural basis in HF condition.}
}
@inproceedings{ISMRM2018_4533,
annote={ISMRM2018_4533},
pages={4533},
file={ISMRM2018_4533.pdf:ISMRM2018_4533.pdf:PDF},
title={On the (non-)equivalency of monopolar and bipolar settings for deep brain stimulation f{MRI} studies of Parkinson’s disease patients},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4533.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ileana Hancu and Radhika Madhavan and Alexandre Boutet and Manish Ranjan and Julia Prusik and Davix Xu and Suneil Kalia and Mojgan Hodaie and Walter Kucharczyk and Jeffrey Ashe and Alfonso Fasano and Julie Pilitsis and Andres Lozano},
abstract={The equivalency of brain responses in fMRI studies of Parkinson’s disease (PD) patients studied in monopolar and bipolar deep brain stimulation (DBS) configurations was assessed. Five PD patients underwent 30s/30s ON/OFF DBS fMRI scans using their clinical (monopolar) settings and an equivalent bipolar setting, in which the cathode remained unchanged and a proximal electrode was rendered positive; the voltage was increased by 30\% to compensate for the reduced efficacy of the bipolar setting. Monopolar and bipolar configurations resulted in different patterns of brain activation; blind monopolar-bipolar conversion should be avoided for purposes of understanding mechanisms of DBS action.}
}
@inproceedings{ISMRM2018_4534,
annote={ISMRM2018_4534},
pages={4534},
file={ISMRM2018_4534.pdf:ISMRM2018_4534.pdf:PDF},
title={The Relationship between Glutamate and {BOLD} signal changes During Face-Name Paired-Associates Encoding and Retrieval Task in Healthy Adults - A combined 1H-{MRS} and f{MRI} study},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4534.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={H Zhang and PW Chiu and SWH Wong and T Liu and GHY Wong and Q Chan and HKF Mak},
abstract={Glutamate is hypothesized to be the neurotransmitter in mediating BOLD fMRI. In our study, face-name paired-associates (FN-PA) encoding and retrieval tasks are used to investigate the relationship between glutamate and the BOLD signal changes in 72 healthy adults of varying age. Our results showed that [Glx]
abs in the left hippocampus to be significantly positively correlated with the activations in the memory-related circuitry obtained from the FN-PA encoding and retrieval tasks. This might implicate the role of glutamate as the neurotransmitter mediating the BOLD signal changes in the memory tasks.}
}
@inproceedings{ISMRM2018_4535,
annote={ISMRM2018_4535},
pages={4535},
file={ISMRM2018_4535.pdf:ISMRM2018_4535.pdf:PDF},
title={Analysis of colour discrimination ability in Parkinson’s Disease patients using f{MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4535.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Shefali Chaudhary and Senthil Kumaran and Vinay Goyal and Achal Srivastava and Gaurishanker Kaloiya and Mani Kalaivani and Rajesh Sagar and Naranamangalam R Jagannathan},
abstract={Ocular and visual disorders has been reported in Parkinson’s Disease (PD). BOLD activation was mapped during visual color hue discrimination stimuli in PD (n=10, mean age=59 years, SD=6.8) and healthy control (HC) (n=6, mean age=53.67 years, SD=2.6) participants at 3 T MR scanner. Comparison between the two groups revealed lower activation in secondary visual areas (BA 18/19) and fusiform gyrus (BA 37), more dependence on memory areas and increased cluster size in PD (in comparison with HC) suggesting impairment in colour hue processing.}
}
@inproceedings{ISMRM2018_4536,
annote={ISMRM2018_4536},
pages={4536},
file={ISMRM2018_4536.pdf:ISMRM2018_4536.pdf:PDF},
title={Association of cerebral perfusion alterations in sudden sensorineural hearing loss detected by arterial spin labeled {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4536.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Xiao-Min Xu and Gao-Jun Teng},
abstract={To explore associations between cerebral blood flow (CBF) and depression by using arterial spin labeled MRI (ASL). Voxel-wise based comparisons between sudden sensorineural hearing loss (SSHL) patients and controls were investigated by whole-brain analysis, which might reflect a new insight into SSHL-related dysregulation and treatment target for psychological abnormalities.}
}
@inproceedings{ISMRM2018_4537,
annote={ISMRM2018_4537},
pages={4537},
file={ISMRM2018_4537.pdf:ISMRM2018_4537.pdf:PDF},
title={Detection of {BOLD} Response in the Limbic System to Non-invasive Stimulation of Autonomic Nervous System with {SMS} at 7T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4537.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Tie-Qiang Li and Yanlu Wang and Masaki Fukunaga},
abstract={Previous studies of clinical patients indicate that kinetic oscillatory stimulation (KOS) in nasal cavity has a positive impact on the functioning of autonomic nervous system (ANS). For better under standing of the mechanisms underlying this treatment efficacy, we used a 7T MRI system equipped with simultaneous multiple slice (SMS) imaging techniques to study the brain activation during a robust block design of KOS.The findings from the current study demonstrate that KOS is effective to induce regulatory response of the CNS control network.}
}
@inproceedings{ISMRM2018_4538,
annote={ISMRM2018_4538},
pages={4538},
file={ISMRM2018_4538.pdf:ISMRM2018_4538.pdf:PDF},
title={Influence of propofol and isoflurane anesthesia in brain activations induced by thermal stimulation and capsaicin: an f{MRI} study in Macaca fascicularis},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4538.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Willy Gsell and Elaine Manigbas and Uwe Himmelreich and Zhimin Wang},
abstract={Preclinical fMRI is often performed under general anesthesia which may compromise the brain reactivity but also interfere with the central effect of test compounds. We hereby performed a comparison of Isoflurane and propofol anesthetic regimens in order to determine the compatibility of both compounds with hyperalgesia induced by capsaicin. Threshold to reach robust somatosensory activation seems to be increased under propofol anesthesia but pain related activation remained at 44 degrees using both anesthetics. Capsaicin induced significant T2* changes in both groups but mismatches were observed suggesting different pathways to be involved and therefore prevail further investigation.}
}
@inproceedings{ISMRM2018_4539,
annote={ISMRM2018_4539},
pages={4539},
file={ISMRM2018_4539.pdf:ISMRM2018_4539.pdf:PDF},
title={Probability distribution of functional areas in human brain},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4539.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Weiwei Men and Sizhong Zhou and Yaoyu Zhang and Xiaolin Chen and Tianyi Qian and Changyu Lu and Jia-Hong Gao},
abstract={fMRI can be used to detect the functional areas of human brain in vivo, which is helpful for neurosurgeons to make accurate pre-surgical plans. Due to the individual differences of the brain, the topography of different functional areas will vary across subjects. The purpose of this study was to construct group functional probability maps of different functional areas based on a large database of normal subjects. It has the potential to help neurosurgeons to make accurate pre-surgical plans and to improve the functional outcome of patients after surgery.}
}
@inproceedings{ISMRM2018_4540,
annote={ISMRM2018_4540},
pages={4540},
file={ISMRM2018_4540.pdf:ISMRM2018_4540.pdf:PDF},
title={Working memory decline in patients with amnestic mild cognitive impairment (a{MCI}) during 2-back tasks},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4540.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Zhaoxia Qin and Mengxing Wang and Jilei Zhang and Haifeng Lu and Shuai Xv and Jianren Liu and Xiaoxia Du*},
abstract={This study investigated brain functional abnormalities that are specifically related to working memory in amnestic mild cognitive impairment (aMCI) patients using fMRI in combination with an n-back task. Nineteen aMCI patients (aged, 52-78 years, 13 female) and 19 age-and gender-matched healthy adults participated in this experiment. In the task performance, aMCI group had lower accuracy on the 2-back task. The aMCI patients exhibited less areas of activation during performance of the 2-back vs. 0-back tasks and more deactivation in the default mode network, compared with healthy group. The aMCI patients exhibited decreased activation in dorsolateral prefrontal cortex and supplementary motor cortex during the 2-back vs. 0-back tasks, compared with healthy group.}
}
@inproceedings{ISMRM2018_4541,
annote={ISMRM2018_4541},
pages={4541},
file={ISMRM2018_4541.pdf:ISMRM2018_4541.pdf:PDF},
title={A comparison of audiovisual and auditory cue based gaming using f{MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4541.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Surabhi Ramawat and Senthil Kumaran and Shefali Chaudhary and Sunita Gudwani and Sadhana Kumari and Rohit Saxena and Naranamangalam R Jagannathan},
abstract={Gaming involves coordination between attention, spatial processing and motor processes. In the present study, fMRI during an audio-video gaming paradigm was carried out in healthy participants (n=6, 2M, 4F, mean age=31.2 years and SD=5.58), in two sessions, with audio-only stimulus and audio-video stimuli. Data processing and inter-group comparison was done using spm12. The results suggest attention, cognitive control and learning processes during the audio-only task as compared to the audiovisual task.}
}
@inproceedings{ISMRM2018_4542,
annote={ISMRM2018_4542},
pages={4542},
file={ISMRM2018_4542.pdf:ISMRM2018_4542.pdf:PDF},
title={Enhancement of midbrain auditory responses to behaviorally relevant vocalization by optogenetically-initiated dorsal hippocampal inputs},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4542.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Celia M. Dong and Russell W. Chan and Alex T. L. Leong and Eddie C. Wong and Ed X. Wu},
abstract={The hippocampus is a central hub of the brain with abundant connections to numerous remote structures. However, whether and how hippocampus interacts with the auditory subcortical regions remains unknown. The inferior colliculus (IC), the auditory midbrain, is the first station where the responses selectivity for vocalization is formed. In this auditory fMRI study, we revealed that IC responses to vocalization, but not broadband noise, could be enhanced by dorsal hippocampal inputs initiated optogenetically. Our findings indicate that hippocampus plays a role in midbrain processing of the behaviorally relevant sound, a phenomenon that was unknown previously.}
}
@inproceedings{ISMRM2018_4543,
annote={ISMRM2018_4543},
pages={4543},
file={ISMRM2018_4543.pdf:ISMRM2018_4543.pdf:PDF},
title={Effects of a high-fat diet in the mouse cerebral response to appetite detected by functional diffusion {MRI} and {HRMAS} studies},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4543.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Irene Guadilla and María José Guillén and Sebastián Cerdán García-Esteller and Pilar López-Larrubia},
abstract={Obesity and overweight are common problems in developed world population, affecting to a greater number of children. In young people, it is becoming more usual to diagnose diabetes or heart problems due to fat accumulation. In this work, we wanted to assess the effects of a fat diet in the cerebral response to an appetite stimulus in mice. We evaluated changes in diffusion magnetic resonance imaging parameters and metabolomic profiles. Our results suggest that high fat diet consumption causes alterations in the brain response to appetite that can be signaled by magnetic resonance approaches.}
}
@inproceedings{ISMRM2018_4544,
annote={ISMRM2018_4544},
pages={4544},
file={ISMRM2018_4544.pdf:ISMRM2018_4544.pdf:PDF},
title={Magnetic resonance to characterize the cerebral response to fasting status in a glioblastoma mouse model},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4544.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Irene Guadilla and María José Guillén and Sebastián Cerdán García-Esteller and Pilar López-Larrubia},
abstract={Involuntary weight loss in patients with cancer is a common secondary effect in tumor pathologies being a cause of weakening and progression of the disease. This phenomenon causes cachexia that is estimated to be the direct cause of at least 20\% of cancer deaths. In this line, untreated intracranial glioma-bearing mice develop cachexia and the use of magnetic resonance imaging characterization of the cerebral response to different appetitive conditions can contribute to the better understanding of the cachectic status. For that, we employed functional diffusion MRI and metabolomic studies in a glioblastoma mouse model.}
}
@inproceedings{ISMRM2018_4545,
annote={ISMRM2018_4545},
pages={4545},
file={ISMRM2018_4545.pdf:ISMRM2018_4545.pdf:PDF},
title={Functional and metabolic magnetic resonance evaluation of the role of the aquaporin-4 in the cerebral response to appetite},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4545.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Irene Guadilla and María José Guillén and Sebastián Cerdán García-Esteller and Pilar López-Larrubia},
abstract={Aquaporin-4 (AQP4) is the main water channel protein found in the brain. It is located at the end-feet of astrocytes allowing to maintain the ion and water balance. In our group, we previously employed functional diffusion magnetic resonance imaging to detect the swelling of astrocytes in response to appetite. In this line, we wanted to study the function of the AQP4 in the volume changes of these glial cells. For that, we administrated a glucose bolus and the aquaporin inhibitor TGN to assess the role of this protein in the brain response to a feeding stimulus.}
}
@inproceedings{ISMRM2018_4546,
annote={ISMRM2018_4546},
pages={4546},
file={ISMRM2018_4546.pdf:ISMRM2018_4546.pdf:PDF},
title={Resting-state sensorimotor networks in adults with atypical swallowing: a f{MRI} study},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4546.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Sidy Fall and Stéphanie Dakpé and Pauline Nicol and Juliette Baudel and Evane Pailler and Sylvie Testelin and Bernard Devauchelle and Patrick Goudot and Jean-Marc Constans},
abstract={Most previous functional neuroimaging studies on swallowing were focused on investigating the cortical (and subcortical) representation of the swallowing functions in healthy individuals using task-related data. The present function magnetic resonance imaging (fMRI) study examine whether individuals with atypical and normal swallowing differ in brain activity patterns associated to the resting-state sensorimotor network. Our findings revealed that the individuals with normal swallowing showed stronger and broader patterns of activation than the individuals with atypical swallowing, particularly in the midcingulate cortex. These differences of activation patterns between the two groups may suggest that the midcingulate cortex is crucially involved in the coordination or/and integration of swallowing functions.}
}
@inproceedings{ISMRM2018_4547,
annote={ISMRM2018_4547},
pages={4547},
file={ISMRM2018_4547.pdf:ISMRM2018_4547.pdf:PDF},
title={Test-Retest Reproducibility of Cerebral Blood Flow at Rest and During A Vigilance Task},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4547.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Hengyi Rao and Fan Yang and Sihua Xu and John A. Detre},
abstract={It is unclear whether ASL test-retest reproducibility would be different between absolute CBF and relative task-induced CBF changes and across resting and task scans. Here we scanned 15 healthy participants three times in a 5-day well-controlled study while participants were at rest and performing a simple vigilance task. Absolute CBF showed excellent test-retest reliability across three days, which were comparable to performance reliability. However, reliability of task-induced CBF changes were much lower than reliability of absolute CBF, suggesting that absolute CBF rather than relative CBF changes may be a more reliable brain function measurement for longitudinal and clinical studies.}
}
@inproceedings{ISMRM2018_4548,
annote={ISMRM2018_4548},
pages={4548},
file={ISMRM2018_4548.pdf:ISMRM2018_4548.pdf:PDF},
title={Inter-subject correlation and adaptation effects across cortical depths in the human auditory cortex during natural music listening},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4548.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Pu-Yeh Wu and Jo-Fu Lotus Lin and Shu-Yu Huang and Shang-Yueh Tsai and Wen-Jui Kuo and Fa-Hsuan Lin},
abstract={We explore the inter-subject correlated BOLD signal across subjects in the auditory cortex acorss cortical depth when listening to musical pieces. More synchronized brain activity was observed at intermediate cortical depths. Repeated listening caused variable modulations on the inter-subject correlated BOLD signal across songs and cortical depths.}
}
@inproceedings{ISMRM2018_4549,
annote={ISMRM2018_4549},
pages={4549},
file={ISMRM2018_4549.pdf:ISMRM2018_4549.pdf:PDF},
title={Calculation of the Susceptibility Effect on the Rate of Transverse Relaxation using Real Microvascular Networks},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4549.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Xiaojun Cheng and Jonathan R. Polimeni and Louis Gagnon and Anna Devor and Sava Sakadžić and Richard B. Buxton and David A. Boas},
abstract={We obtain the exponent in the power law relation of the transverse relaxation rate and the susceptibility difference between vessels and tissue from first-principles calculations using our recently developed VAN model. We find that this exponent is close to 1 and is more uniformly distributed across regions athigher magnetic field strengths. The results from the uniform vascular partitioning relevant for BOLD fMRI are compared and the exponent is closer to 1 for the latter. These help inform interpretation fo the physiological variables including CMRO2 and CBV from BOLD and contrast-enhanced fMRI respectively.}
}
@inproceedings{ISMRM2018_4550,
annote={ISMRM2018_4550},
pages={4550},
file={ISMRM2018_4550.pdf:ISMRM2018_4550.pdf:PDF},
title={f{MRI} mapping of brain-wide networks to optogenetically-evoked spindle-like activity from somatosensory thalamus},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4550.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Xunda Wang and Alex T. L. Leong and Karim El Hallaoui and Celia M. Dong and Ed X. Wu},
abstract={The brain is a highly complex, interconnected structure with parallel and hierarchical networks distributed within and between neural systems. During information processing in the brain, spontaneous oscillatory neural events such as slow oscillations, spindlesand sharp wave ripples provoke global dynamic patterns. We propose that spindle-like optogenetic stimulation can be employed to study global interaction patterns in long-range networks by stimulating the ventral posteromedial thalamus (VPM) thalamocortical excitatory neurons.}
}
@inproceedings{ISMRM2018_4551,
annote={ISMRM2018_4551},
pages={4551},
file={ISMRM2018_4551.pdf:ISMRM2018_4551.pdf:PDF},
title={Video C3D features learned by deep network correlate with functional {MRI} signal variation associated with the video},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4551.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Xu Chen and Jason Langley and Sujoy Paul and Tahmida Mahmud and Amit K Roy-Chowdhury and Aaron Seitz and XiaoPing Hu},
abstract={To gain further insights into the mechanisms of deep network learning from the perspective of brain imaging, we compared spatio-temporal features of video segments extracted via a 3-dimensional convolutional network (3D ConvNets) with video representations in human brain characterized by functional MRI signal variation when viewing video segments. We found correlations between C3D features and fMRI signal variation in brain regions selectively activated by video segments after the optimization of time lag due to the hemodynamic response function (HRF). Distinct activation patterns were also revealed by functional MRI for video segments classified as different classes of activity.}
}
@inproceedings{ISMRM2018_4552,
annote={ISMRM2018_4552},
pages={4552},
file={ISMRM2018_4552.pdf:ISMRM2018_4552.pdf:PDF},
title={Olfactory functional magnetic resonance imaging in the human brain at 7 Tesla},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4552.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ikuhiro Kida and Yuka Donoshita and Uksu Choi},
abstract={In contrast to the understanding of the visual and auditory functions, the understanding of the olfactory function in the human brain is less advanced. Because the regions involved in olfaction are prone to signal losses due to strong magnetic field inhomogeneity in the susceptibility boundary between air in the paranasal sinuses and brain tissues, a study of olfaction using functional MRI (fMRI) is challenging, especially at ultra-high magnetic field strength (UHF). In this study, we investigated the role of olfactory fMRI with high spatial resolution at 7T involving the ventral brain area. We found that the brain activations are reproducible within and between subjects. These results suggested that fMRI with high spatial resolution at UHF has the potential for use in olfaction studies, also involving the ventral brain regions.}
}
@inproceedings{ISMRM2018_4553,
annote={ISMRM2018_4553},
pages={4553},
file={ISMRM2018_4553.pdf:ISMRM2018_4553.pdf:PDF},
title={A pneumatic tactile stimulus to explore the primary somatosensory area with f{MRI}, at different magnetic fields},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4553.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Laura Biagi and Paolo Cecchi and Simona Fiori and Graziella Donatelli and Andrea Guzzetta and Giovanni Cioni and Michela Tosetti and Mirco Cosottini},
abstract={Difficulties to separate sensory and motor activations in fMRI studies limited the potentialities of the technique to study mechanisms of plasticity and processes of re-organization occurring in primary somatosensory area after brain lesions. Here we present the results of the use of a tactile stimulus developed ad hoc to investigate this area at different magnetic fields. The tactile stimulator is able to activate selectively a specific area in post-central region at 3T and 7T and thanks to its safety and handiness it seems a useful tool to study (re-)organization processes in patients with brain lesion.}
}
@inproceedings{ISMRM2018_4554,
annote={ISMRM2018_4554},
pages={4554},
file={ISMRM2018_4554.pdf:ISMRM2018_4554.pdf:PDF},
title={The alexithymic trait is reflected in emotional processing in subjects below the threshold of alexithymic disorder.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4554.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Johanna Närväinen and Pekka Kuoppa and Leila Karhunen and Sanna Sinikallio and Mervi Könönen and Mika P Tarvainen},
abstract={Alexithymia is a disorder linked to altered brain processing of emotions and to other disorders and substance abuse. In sub-disorder range, alexithymia can be considered a personality trait. In this paper, we first characterize the fMRI results of emotion induction in non-alexithymic subjects and then explore the correlation between brain activation in amygdala, anterior cingulate cortex and prefrontal cortex; and the degree of the alexithymic trait assessed by TAS-20 questionnaire. As conclusion, the alexithymic trait seems to be reflected in emotional processing already in subjects well below the threshold of alexithymia disorder.}
}
@inproceedings{ISMRM2018_4555,
annote={ISMRM2018_4555},
pages={4555},
file={ISMRM2018_4555.pdf:ISMRM2018_4555.pdf:PDF},
title={
Support vector machine prediction of clinical pain response using resting-state f{MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4555.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Scott J. Peltier and Eric Ichesco and Lynne Pauer and Daniel J. Clauw and Richard E. Harris},
abstract={The mechanisms of chronic pain and its response to pharmacological treatment remains an open challenge. Multivariate pattern analysis can offer an alternative to standard analysis techniques. This study applies SVM classification in resting-state fMRI data to predict improvements in clinical pain after drug therapy.
}
}
@inproceedings{ISMRM2018_4556,
annote={ISMRM2018_4556},
pages={4556},
file={ISMRM2018_4556.pdf:ISMRM2018_4556.pdf:PDF},
title={Non-invasive estimation of fetal lung maturity using {MR} spectroscopy},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4556.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Vidya Rajagopalan and Stefan Bluml},
abstract={Magnetic resonance spectroscopy (MRS) can potentially be used to non-invasively measure the lipid levels in the amniotic fluid (AF), in-utero, to determine fetal lung maturity (FLM). This would eliminate the need to perform invasive and risky amniocentesis solely to determine FLM. In this study we measured the lipid to water ratio in the amniotic fluid of women with normal pregnancies. Our results showed that this ratio remained steady until after 36 gestational weeks at which point it increased exponentially. This indicates that MRS is a potential replacement for amniocentesis for estimating FLM.}
}
@inproceedings{ISMRM2018_4557,
annote={ISMRM2018_4557},
pages={4557},
file={ISMRM2018_4557.pdf:ISMRM2018_4557.pdf:PDF},
title={Feasibility of Estimating Umbilical Vein Oxygen Saturation with Susceptometry-Based Oximetry},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4557.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ana E Rodríguez-Soto and Michael C Langham and Nadav E Schwartz and Felix W Wehrli},
abstract={Quantitative MRI allows the estimation of fetal oxygen transport in vivo, for which knowledge of the oxygen saturation (HbO
2) of blood in the umbilical vein (UV) is required. The method of choice to estimate HbO
2 in fetal applications is T
2-based oximetry, which requires a sequence-specific calibration equation to convert blood T
2 to HbO
2. Therefore, in the present work we examined the feasibility of using susceptometry-based oximetry (SBO) to measure HbO
2 at the UV as it is calibration-free and implementable across field strengths. Results show, in a limited number of participants, no difference in HbO
2 measured with both MRI-based oximetric techniques.}
}
@inproceedings{ISMRM2018_4558,
annote={ISMRM2018_4558},
pages={4558},
file={ISMRM2018_4558.pdf:ISMRM2018_4558.pdf:PDF},
title={Estimating global cerebral venous oxygenation in the human fetus using {QSM}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4558.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Brijesh Kumar Yadav and Sagar Buch and Uday Krishnamurthy and Pavan Jella and Edgar Hernandez-Andrade and Anabela Trifan and Lami Yeo and Sonia Hassan and E. Mark Haacke and Roberto Romero and Jaladhar Neelavalli},
abstract={Unobstructed oxygen supply is important for proper health and development of the growing fetus and therefore, fetal cerebral oxygenation measurement has been attempted previously using SWI. However, vessel curvature and oblique fetal orientation posed a major challenge in the oxygenation measurement, especially in younger foetuses. To overcome these problems, we present the first application of quantitative susceptibility mapping for the fetal brain oxymetry. We also studied the effect of resolution on QSM using simulations. Results showed the mean putative fetal cerebral oxygenation was 67\%±7\% and minimum of 5 voxels around the vessel and 5 slices gives <3\% error in oxygenation.}
}
@inproceedings{ISMRM2018_4559,
annote={ISMRM2018_4559},
pages={4559},
file={ISMRM2018_4559.pdf:ISMRM2018_4559.pdf:PDF},
title={Assessment of the effect of maternal posture on the placental oxygenation transport by means of {BOLD} {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4559.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Esra Abaci Turk and Jie Luo and Natalie Copeland and Michelle Restrepo and Ata Turk and Borjan Gagoski and Lawrence L. Wald and Elfar Adalsteinsson and Drucilla J. Roberts and Polina Golland and P. Ellen Grant and William H. Barth Jr},
abstract={Aorta-caval compression due to maternal posture can change uterine artery blood flow, which is the major determinant of maternal intervillous perfusion and may affect MRI measures of placental oxygenation. We investigated the effect of maternal posture on estimates obtained from BOLD MRI of the placenta. We observed higher oxygenation signals in the supine position for a group at younger gestational age. In the group with higher gestational age, the influence of the maternal position on oxygen transport was inconsistent. These findings underscore the need to account for the effect of maternal posture on MRI studies of utero-placental circulation.}
}
@inproceedings{ISMRM2018_4560,
annote={ISMRM2018_4560},
pages={4560},
file={ISMRM2018_4560.pdf:ISMRM2018_4560.pdf:PDF},
title={The development of fat in fetus: Observation by magnetic resonance imaging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4560.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={TING YI CHEN and SHU HUEI SHEN and NAI CHI CHIU and HAN JUI LEE and SZ SHIAN YU and WAN YOU GUO},
abstract={The fetal structures including fat change vigorously during the development progress. In this study, by using 2-point Dixon method, we demonstrated that the fetal fat development followed a predictable chronological sequence in terms of both location and composition. The fat at face appears the earliest at 22-23 weeks, followed by subcutaneous fat of other body part in the order of buttock, thigh, posterior neck, upper arm and lower back. Most subcutaneous fat could be well visualized at 27-28 weeks. The fat at deep part appeared later. The fat fraction in all body part gradually increased as the development progress.}
}
@inproceedings{ISMRM2018_4561,
annote={ISMRM2018_4561},
pages={4561},
file={ISMRM2018_4561.pdf:ISMRM2018_4561.pdf:PDF},
title={3D Water-Fat {MRI} Detection of Developmental Maturity in Fetal Adipose Tissue Compartments},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4561.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Stephanie A Giza and Tianna L Koreman and Barbra de Vrijer and Charles A McKenzie},
abstract={Fetal adipose tissue begins development at different gestational ages in different regions of the body. Proton density fat fraction (PDFF) increases with gestational age as fetal adipocytes fill with lipid. The PDFF was found to be significantly different in different regions of the body in mid-late gestation fetuses.}
}
@inproceedings{ISMRM2018_4562,
annote={ISMRM2018_4562},
pages={4562},
file={ISMRM2018_4562.pdf:ISMRM2018_4562.pdf:PDF},
title={Prediction of invasive placenta with quantitative placental textures features from clinical {MRI} scan},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4562.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Huaiqiang Sun and Haoyang Xing and Haibo Qu and Yi Liao and Xiaoxia Zhou and Zhiyi Zhou and Qiyong Gong and Shu Zhou},
abstract={A machine learning framework that can predict invasive placenta with MRI texture features and identify significant relevant image features}
}
@inproceedings{ISMRM2018_4563,
annote={ISMRM2018_4563},
pages={4563},
file={ISMRM2018_4563.pdf:ISMRM2018_4563.pdf:PDF},
title={Oxygen transfer through the placenta on hyperoxia},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4563.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Simon Shah and Nia Jones and Lucy Edwards and Richard Bowtell and Penny Gowland},
abstract={Rapid transport of oxygen through the placenta is important to ensure efficient exchange. The aim of this work was to measure the rate of oxygenation distribution across the placenta on hyperoxia using susceptibility mapping. It also attempts to relate the rate of uptake of oxygen in the placenta to the total flow to the placenta. It was observed that upon hyperoxia the susceptibility decreased as the BOLD signal increased in the placenta. We propose that that the rate of homogenization of susceptibility is a marker of transport through the placenta.}
}
@inproceedings{ISMRM2018_4564,
annote={ISMRM2018_4564},
pages={4564},
file={ISMRM2018_4564.pdf:ISMRM2018_4564.pdf:PDF},
title={Movement of blood within the placenta},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4564.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Simon Shah and Nia Jones and Lucy Edwards and Richard Bowtell and Penny Gowland},
abstract={Healthy placental function requires optimum percolation of blood throughout the intervillous space to provide adequate feto-maternal exchange. This depends on blood flow from the spiral arteries and permeability of the intervillous space - both being altered in conditions leading to fetal growth restriction. This study explores the use of diffusion based MRI to visualise and depict the blood flow within the placenta and explore the underlying micro-structure, including the repeatability of the measures.}
}
@inproceedings{ISMRM2018_4565,
annote={ISMRM2018_4565},
pages={4565},
file={ISMRM2018_4565.pdf:ISMRM2018_4565.pdf:PDF},
title={Rapid single slice multidimensional fetal flow imaging with {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4565.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Datta Singh Goolaub and Christopher Roy and Dafna Sussman and Mike Seed and Christopher Macgowan},
abstract={In this study, we demonstrate multidimensional fetal blood flow quantification, using a novel radial phase contrast sampling strategy combined with compressed sensing reconstruction. This acquisition and analysis pipeline provides high temporal resolution real-time reconstructions that enable image-based gating for subsequent CINE reconstruction. Experimental validation of gating and flow quantitation are presented from an adult volunteer. Preliminary results in two human fetuses show the feasibility of this novel strategy for multidimensional fetal flow in imaging in a single slice.}
}
@inproceedings{ISMRM2018_4566,
annote={ISMRM2018_4566},
pages={4566},
file={ISMRM2018_4566.pdf:ISMRM2018_4566.pdf:PDF},
title={Placental Functional Imaging with Endogenous Contrast: Preliminary Comparison of {BOLD} Effect and {ASL} {FAIR} in Rhesus Macaque and Human},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4566.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ante Zhu and Kai D. Ludwig and Wei Zha and Sydney Nguyen and Thaddeus G. Golos and Ian M. Bird and Dinesh M. Shah and Oliver Wieben and Sean B. Fain and Scott B. Reeder and Diego Hernando and Kevin M. Johnson},
abstract={Non-invasive MRI techniques are needed to quantify placental perfusion and oxygenation during pregnancy. In this work, we assessed the feasibility and correspondence of T2* mapping and arterial spin labeling (ASL) to evaluate placental oxygen delivery. Six pregnant rhesus macaques and seven pregnant women underwent MRI that included T2* mapping and ASL with flow-sensitive alternating inversion recovery (FAIR). Regions of locally high ASL perfusion signal correlated spatially with the regions of locally maximum T2* in animals and humans. The two imaging techniques with endogenous contrast are promising approaches for the detection of oxygen delivery via the placenta.}
}
@inproceedings{ISMRM2018_4567,
annote={ISMRM2018_4567},
pages={4567},
file={ISMRM2018_4567.pdf:ISMRM2018_4567.pdf:PDF},
title={Proton Spectroscopy of the Human Placenta In-Utero to Establish Normal Ranges Throughout Gestation},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4567.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={David M Morris and Gillian Macnaught and Marian C Aldhous and Fiona C Denison and Scott IK Semple},
abstract={For magnetic resonance proton spectroscopy to be of potential future use in investigating placental dysfunction in-utero, a normal range of detectable metabolites is required. Seventy-seven healthy pregnant women with an uncomplicated singleton pregnancy were scanned between 20 and 40 week's gestation. Robust quality assurance removed compromised data and spectra were quantified for the commonly observed peaks and metabolites expected in the placenta. A characteristic spectrum was observed, which was independent of gestational age. Quantification of this technique in terms of the expected results and their variability will inform future studies and suggest technical improvements that may be useful.}
}
@inproceedings{ISMRM2018_4568,
annote={ISMRM2018_4568},
pages={4568},
file={ISMRM2018_4568.pdf:ISMRM2018_4568.pdf:PDF},
title={An {MRI} assessment of inferior vena cava vessel morphology and venous flow in chronic hypertensive and normotensive pregnant women in the supine position.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4568.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ana Isabel Dos Santos Gomes and Emer Hughes and Alison Ho and Anthony Price and Christopher Kelly and Jana Hutter and Joseph Hajnal and Lucy Chapell and Mary Rutherford},
abstract={The supine position in pregnancy may develop supine hypertensive syndrome (SHS) caused by the gravid uterus compressing the inferior vena cava (IVC) and compromising venous return. The effect of positioning on vessel morphology and venous return in chronic hypertensive pregnant women has not been assessed. We used phase contrast imaging to assess matched groups of chronic hypertensive and normotensive women in the supine position. There were no significant differences in IVC morphology or venous return between the two groups, supporting the conclusion that chronic hypertensive women are not at higher risk than normotensives when supine.}
}
@inproceedings{ISMRM2018_4569,
annote={ISMRM2018_4569},
pages={4569},
file={ISMRM2018_4569.pdf:ISMRM2018_4569.pdf:PDF},
title={Fetal Cardiac Hemodynamics: Initial Experience using 4D flow {MRI} in Large Animal Models},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4569.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Eric M. Schrauben and Brahmdeep Saini and Jack R.T. Darby and Jia Yin Soo and Mitchell C. Lock and Elaine Stirrat and Aodhnait S. Fahy and Joshua Bradshaw and Greg Stortz and John G. Sled and Janna L. Morrison and Mike Seed and Christopher K. Macgowan},
abstract={4D flow MRI, coupled with advanced surgical preparation of animal subjects, is performed to capture fetal cardiac hemodynamics in two animal models of late gestation pregnancy – pig and sheep. Characterization and visualization of complex flow is presented alongside quantitative measures of flow in major fetal cardiac vessels and shunts.}
}
@inproceedings{ISMRM2018_4570,
annote={ISMRM2018_4570},
pages={4570},
file={ISMRM2018_4570.pdf:ISMRM2018_4570.pdf:PDF},
title={Exploring placental function over gestation using multi-modal functional {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4570.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jana Hutter and Paddy Slator and Laurence Jackson and Alison Ho and Ana Dos Santos Gomes and Anthony N Price and Daniel Alexander and Lucy Chappell and Mary Rutherford and Joseph V Hajnal},
abstract={The delivery of oxygen and nutrients to the growing fetus in the human placenta is crucial for any successful pregnancy. Major pregnancy complications such as growth restriction and pre-eclampsia have been linked to placental insufficiency. This study attempts to use a comprehensive multi-modal functional MRI approach to visualize and quantify the complexity of the underlying structural and functional processes and monitor their evolution over gestation. The required placenta data can be acquired in the clinically feasible time of ~12 min and requires no contrast agent. The presented acquisition is completed by a dedicated multi-modal pipeline and a set of quantitative features.}
}
@inproceedings{ISMRM2018_4571,
annote={ISMRM2018_4571},
pages={4571},
file={ISMRM2018_4571.pdf:ISMRM2018_4571.pdf:PDF},
title={Optimised b-values and Gradient Directions for Placental Diffusion {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4571.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Paddy J Slator and Jana Hutter and Laurence H Jackson and Andrada Ianus and Ana Dos Santos Gomes and Alison Ho and Lisa Story and Laura McCabe and Eleftheria Panagiotaki and Mary Rutherford and Joseph V Hajnal and Daniel C Alexander},
abstract={Diffusion MRI (dMRI) has the potential to assess placental microstructure and microcirculation in-vivo and hence provide insight into conditions such as fetal growth restriction and pre-eclampsia. The utility of dMRI data depends heavily upon the choice of b-values and gradient directions, although these choices have to be weighed against scanning time restrictions. To address these issues, we developed an organ-specific, data-driven, clinically-viable protocol for placental dMRI. This optimised protocol compares favourably with a naive protocol of comparable scan time.}
}
@inproceedings{ISMRM2018_4572,
annote={ISMRM2018_4572},
pages={4572},
file={ISMRM2018_4572.pdf:ISMRM2018_4572.pdf:PDF},
title={Perfusion {MRI} of the Placenta by Arterial Spin Labeling ({ASL}) and Ferumoxytol Dynamic Contrast Enhanced ({DCE}) {MRI} in the Rhesus Macaque},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4572.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Kai D Ludwig and Sean B Fain and Sydney Nguyen and Thaddeus G Golos and Scott B Reeder and Ian M Bird and Oliver E Wieben and Dinesh M Shah and Kevin M Johnson},
abstract={We evaluate two ASL based techniques for non-contrast measurement of perfusion compared with ferumoxytol-based DCE MRI in ten pregnant rhesus macaques. Localized regions of ASL perfusion were observed that coincided with regions of early contrast arrival times and high relative blood flow as seen in DCE, likely identifying locations of material spiral artery inputs into the placenta intervillous space.}
}
@inproceedings{ISMRM2018_4573,
annote={ISMRM2018_4573},
pages={4573},
file={ISMRM2018_4573.pdf:ISMRM2018_4573.pdf:PDF},
title={Quantitative ferumoxytol {DCE} {MRI} of the primate placenta perfusion domains},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4573.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Kai D Ludwig and Sean B Fain and Erin B Adamson and Sydney Nguyen and Thaddeus G Golos and Scott B Reeder and Ian M Bird and Oliver E Wieben and Dinesh M Shah and Kevin M Johnson},
abstract={The placental vascular network is organized to effectively mediate exchange of nutrients, oxygen and waste between mother and fetus. We report on the estimated number of placental functional domains in a healthy population of rhesus macaques using ferumoxytol DCE MRI. Noninvasive imaging of the maternal vasculature organization and localized perfusion within the placenta may be a sensitive biomarker to predict pregnancy complications.}
}
@inproceedings{ISMRM2018_4574,
annote={ISMRM2018_4574},
pages={4574},
file={ISMRM2018_4574.pdf:ISMRM2018_4574.pdf:PDF},
title={{ADC} and perfusion fraction f obtained by {IVIM} model are markers of maternal and fetal human placenta development in normal pregnancy},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4574.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Amanda Antonelli and Silvia Capuani and Michele Guerreri and Silvia Bernardo and Carlo Catalano and Lucia Manganaro},
abstract={The purpose was to investigate the potential of IVIM model to quantify diffusion and perfusion in human placenta of normal pregnancy. The relation between Apparent diffusion coefficient ADC, perfusion fraction f and pseudo-diffusion coefficient D* obtained in fetal and maternal placenta with microstructural changes occurring during placenta development was investigated. 30 pregnant women (gestational age, GA range = 19-37w) underwent DW examination with b=0,10,30,50,75,100,150,400,700,1000s/mm2. The Pearson correlations between ADC, D*, f and clinical data (GA, Body-Mass Index and basal Glycaemia) were evaluated. ADCvsGA showed significant positive and negative correlation during the II and III trimester of gestation, respectively.}
}
@inproceedings{ISMRM2018_4575,
annote={ISMRM2018_4575},
pages={4575},
file={ISMRM2018_4575.pdf:ISMRM2018_4575.pdf:PDF},
title={High dielectric material application in fetal {MR} imaging at 3T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4575.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Chao Luo and Nan Li and Guoxi Xie and Xiaoliang Zhang and Xin Liu and Ye Li},
abstract={In this paper, we evaluated the imaging performance in fetal imaging for supine and lateral positions of pregnant patients with/without high permittivity dielectric pad at 3T through numerical modeling and simulation. The results suggest that the lateral position is advantageous over the supine positions in terms of B1+ efficiency and SAR or MR safety.}
}
@inproceedings{ISMRM2018_4576,
annote={ISMRM2018_4576},
pages={4576},
file={ISMRM2018_4576.pdf:ISMRM2018_4576.pdf:PDF},
title={Metabolic imaging of rodent placenta using hyperpolarized 13C pyruvate {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4576.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Renuka Sriram and Jeremy Gordon and Robert A Bok and Eugene Milshteyn and Daniel B Vigneron and Peder E.Z Larson and John Kurhanewicz and Priyanka Jha},
abstract={We have demonstrated the initial feasibility of hyperpolarized carbon-13 MRI assessment of placental metabolism in a pregnant rat model using [1-
13C]pyruvate. This opens avenues for multiple applications investigating metabolic changes of placental dysfunction detrimental to maternal and fetal health.}
}
@inproceedings{ISMRM2018_4577,
annote={ISMRM2018_4577},
pages={4577},
file={ISMRM2018_4577.pdf:ISMRM2018_4577.pdf:PDF},
title={Spatial Vascular Heterogeneity in the Normal Placenta Assessed with Multi-compartment Placental {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4577.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Rosalind Aughwane and Andrew Melbourne and David Owen and Magdalena Sokolska and Alan Bainbridge and David Atkinson and Jan Deprest and Giles Kendall and Tom Vercauteren and Sebastien Ourselin and Anna David},
abstract={The placenta is perfused by the fetus and mother, allowing oxygen and nutrients to be transferred to the developing fetus. Histologically there is large variation in vascularity within normal placentae but this has not been studied in vivo. The DECIDE model was fitted to separate signals from fetal and maternal perfusion. We imaged placental perfusion using the multi-compartment MR DECIDE model over the placental volume to investigate signal heterogeneity in four uncomplicated singleton pregnancies. The spatial composition of the placenta is investigated by inspecting the parametric heterogeneity across the organ.}
}
@inproceedings{ISMRM2018_4578,
annote={ISMRM2018_4578},
pages={4578},
file={ISMRM2018_4578.pdf:ISMRM2018_4578.pdf:PDF},
title={Fast, automated slice prescription of standard anatomical planes for fetal brain {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4578.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Malte Hoffmann and Borjan Gagoski and Esra A Turk and Paul Wighton and M Dylan Tisdall and Martin Reuter and Elfar Adalsteinsson and P Ellen Grant and Lawrence L Wald and André J W van der Kouwe},
abstract={Motion limits MRI of the fetal brain to rapid 2D acquisitions with low resolution. Even with such sequences, it is challenging to obtain images aligned with standard anatomical planes of the brain and views rendered retrospectively across slices typically suffer from artifacts due to between-slice motion. Here, we present an automated on-scanner slice prescription: immediately before sequence execution, the FOV/slice tilt is updated to match the orientation and position of the brain, derived from the previous acquisition. The fast update is achieved by registration to a template.}
}
@inproceedings{ISMRM2018_4579,
annote={ISMRM2018_4579},
pages={4579},
file={ISMRM2018_4579.pdf:ISMRM2018_4579.pdf:PDF},
title={In Utero Mouse Embryo Imaging Using Inductive Over-Coupling Clip Coil},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4579.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Orlando Aristizabal and Dung Hoang and Choong Heon Lee and Zakia B.Y. Gironda and Jiangyang Zhang and Daniel H Turnbull and Youssef ZaimWadghiri Wadghiri},
abstract={In-utero fetal imaging is prone to respiratory and cardiac artifacts from the mother. These motion artifacts can be reduced via gated- or self-gated navigator acquisitions. For random fetal movements, each subject must be immobilized within the RF coil or require rapid acquisition and serial co-registration involving complex off-line image processing and high performance hardware that may not be available. We propose the use of 3D printed cylindrically shaped clip to effectively immobilize embryos incorporating a resonator mutually coupled with a surface resonator while ensuring an optimized filling factor. Our setup results in increased sensitivity demonstrated via high quality volumetric datasets.
}
}
@inproceedings{ISMRM2018_4580,
annote={ISMRM2018_4580},
pages={4580},
file={ISMRM2018_4580.pdf:ISMRM2018_4580.pdf:PDF},
title={Renal {BOLD} \& Diffusion {MRI} in {CKD}: First Application to a Multi-center Trial},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4580.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Wei Li and Tamara Isakova and Stuart M Sprague and COMBINE Investigators and Pottumarthi V Prasad},
abstract={There is growing interest in applying functional MRI methods to patient studies, especially BOLD and Diffusion MRI in patients with chronic kidney disease. We have had the opportunity to analyze data from a multi-center trial involving patients with advanced CKD (stage 3B \& 4) with multiple etiologies. A healthy control group was used to compare the patient cohort. Data shows small increase in cortical R2*, decrease in medullary R2* and response to furosemide in CKD. ADC was reduced in CKD and was correlated with medullary R2*.}
}
@inproceedings{ISMRM2018_4581,
annote={ISMRM2018_4581},
pages={4581},
file={ISMRM2018_4581.pdf:ISMRM2018_4581.pdf:PDF},
title={Multiparametric {MRI} for assessment of renal transplant fibrosis: preliminary results.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4581.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Octavia Bane and Stefanie Hectors and Sonja Gordic and Paul Kennedy and Mathilde Wagner and Rafael Khaim and Veronica Delaney and Madhav Menon and Fadi El Salem and Sara Lewis and Bachir Taouli},
abstract={The goal of our study is to develop a multiparametric MRI (mpMRI) protocol for the assessment of renal transplant fibrosis. Our initial results show decrease of cortical and medullary ADC, cortical D and PF and increase of cortical T1 in fibrotic allografts compared to functional allografts. We also observed loss of corticomedullary differentiation in ADC and T1 with fibrosis. We conclude that diffusion and T1 measurements are sensitive to renal allograft fibrosis, to be confirmed in a larger study.}
}
@inproceedings{ISMRM2018_4582,
annote={ISMRM2018_4582},
pages={4582},
file={ISMRM2018_4582.pdf:ISMRM2018_4582.pdf:PDF},
title={Use of Multiparametric {MRI} in assessment of Chronic Kidney Disease: reproducibility, correlation with histology and progression},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4582.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Charlotte E Buchanan and Huda Mahmoud and Eleanor F Cox and Benjamin L Prestwich and Nicholas M Selby and Maarten W Taal and Susan T Francis},
abstract={We use multi-parametric renal MRI including T
1, ASL perfusion and DWI to assess structural and haemodynamic changes in CKD patients compared to healthy volunteers (HV). A significant increase in renal cortex and medulla T
1 (and reduced corticomedullary differentiation) and reduction in renal cortex perfusion, was found between CKD patients and HVs. MRI measures in CKD patients were highly reproducible. A significant negative correlation was found between renal cortex T
1 and eGFR and a positive correlation of corticomedullary differentiation and perfusion with eGFR. Renal cortex T
1 and corticomedullary differentiation correlated most strongly with quantitative biopsy measures of renal interstitial fibrosis (IF).}
}
@inproceedings{ISMRM2018_4583,
annote={ISMRM2018_4583},
pages={4583},
file={ISMRM2018_4583.pdf:ISMRM2018_4583.pdf:PDF},
title={{MRI} assessment of renal function in Acute Kidney Injury and associated longitudinal changes with recovery},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4583.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Charlotte E Buchanan and Huda Mahmoud and Eleanor F Cox and Benjamin L Prestwich and Maarten W Taal and Nicholas M Selby and Susan T Francis},
abstract={Acute Kidney Injury (AKI), a sudden reduction in kidney function, arises from a number of causes with the degree of renal recovery varying widely between individuals. We use multi-parametric MRI to monitor renal changes at the time of AKI and during the subsequent recovery from AKI. At peak AKI, an increase in renal volume and both renal cortex and medulla T
1 was seen. Medullary T
1 significantly correlated with the severity of biochemical injury as measured by serum creatinine, whilst no significant correlation was found for cortex T
1. At 3 months post AKI, T1 remained elevated compared to healthy volunteers.}
}
@inproceedings{ISMRM2018_4584,
annote={ISMRM2018_4584},
pages={4584},
file={ISMRM2018_4584.pdf:ISMRM2018_4584.pdf:PDF},
title={Depiction of Transplant Renal Vascular Anatomy and Complications: Unenhanced {MR} Angiography by Using Spatial Labeling with Multiple Inversion Pulses},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4584.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Hao Tang and Zhen Li and Xianlun Zou and Daoyu Hu},
abstract={In this study, the preliminary data from our study demonstrate that SLEEK sequence was capable of displaying transplant renal vascular anatomy and complications. Our results show that consistantly high-quality images can be obtained by using SLEEK, which enabled visualization of even small branches within the transplant renal parenchyma and subtle accessory renal arteries. However, because the signal of the arteries depends on the cardiac output of the patient, a suboptimal blood-suppression TI may lead to poor signal-to-noise ratio and vessel depiction. We did not obtain an additional scout image, which may be helpful in evaluating the flow velocity in the aorta to optimize the blood-suppression TI; thus, a larger study for full comparative evaluation of diagnostic performance is necessary. In conclusion, unenhanced MR angiography with SLEEK preliminarily proved to be a reliable diagnostic method for depiction of anatomy and complications of renal vascular transplant. It may be used for evaluation of patients with renal transplant and in particular for those with renal insufficiency.}
}
@inproceedings{ISMRM2018_4585,
annote={ISMRM2018_4585},
pages={4585},
file={ISMRM2018_4585.pdf:ISMRM2018_4585.pdf:PDF},
title={{ADC} and T1-weighted {MRI} Identifies Necrosis in Wilms Tumours Without the Need for Contrast Agents},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4585.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Harriet Rogers and Martijn Verhagen and Christopher Clark and Patrick Hales},
abstract={Wilms Tumour (WT) is a paediatric renal tumour. Identifying necrosis in WT is clinically important; it can assess patients’ chemotherapy response and ultimately predict progression-free survival. It is also important for guiding biopsies. Lack of enhancement following intravenous administration of gadolinium is commonly used to identify necrosis, however, WT is a kidney tumour and the use of gadolinium is contra-indicated in patients with renal failure. In this study we demonstrate how apparent diffusion coefficient values from DWI and pre-gad T
1 imaging can predict the level of enhancement in WT and quantify the percentage of necrotic tissue without exogenous contrast agents.}
}
@inproceedings{ISMRM2018_4586,
annote={ISMRM2018_4586},
pages={4586},
file={ISMRM2018_4586.pdf:ISMRM2018_4586.pdf:PDF},
title={{IVIM} {DWI} evaluation in assessment of of Diabetic Nephropathy: a initial clinical application},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4586.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={long Liang and Yingjie mei and Yunfan Wu and Guomin Li and Mengchen Liu and Guihua Jiang},
abstract={Previous studies using IVIM DWI in evaluating the dynamic change of renal functions both in normal and CIAKI rats’ kidney, However, to the best of our knowledge, this techniques have not been explored to evaluate Diabetic Nephropathy(DN). In oue study, we found that IVIM DWI showed potential value of clinical application in DN.}
}
@inproceedings{ISMRM2018_4587,
annote={ISMRM2018_4587},
pages={4587},
file={ISMRM2018_4587.pdf:ISMRM2018_4587.pdf:PDF},
title={{MR} elastography and {US} elastography for assessment of renal transplant dysfunction: preliminary results.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4587.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Paul Kennedy and Octavia Bane and Sonja Gordic and Stefanie Hectors and Mark Berger and Rafael Khaim and Veronica Delaney and Madhav Menon and Fadi El Salem and Sara Lewis and Bachir Taouli},
abstract={The aim of this study is to determine whether MR and US elastography methods can differentiate functional and chronically dysfunctional renal allografts by measuring renal corticomedullary stiffness with MR elastography (MRE) and cortex stiffness with ultrasound point shear wave elastography (pSWE). Our preliminary results indicate that renal stiffness measured with MRE is significantly increased in dysfunctional kidneys, while no significant difference was found with pSWE. Renal stiffness measured with MRE also significantly correlated with Banff scores for interstitial fibrosis and tubular atrophy. These preliminary results suggest that MRE is sensitive to fibrotic changes in chronically dysfunctional allografts.}
}
@inproceedings{ISMRM2018_4588,
annote={ISMRM2018_4588},
pages={4588},
file={ISMRM2018_4588.pdf:ISMRM2018_4588.pdf:PDF},
title={Usefulness of Testicular Volume, Apparent Diffusion Coefficient and Normalized Apparent Diffusion Coefficient in the Magnetic Resonance Imaging in Evaluation of Infertile Men with Azoospermia},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4588.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Sung Bin Park and Byoung Hee Han and Hyun Jeong Park},
abstract={It is important to distinguish the obstructive type from the non-obstructive type of azoospermia.
To distinguish obstructive from non-obstructive azoospermia, it is useful and important to measure testicular volume using these techniques. To our knowledge, no reports have used DWI to evaluate the testes in case of azoospermia. Therefore, the present study aimed to evaluate the ability of testicular volume, ADC and normalized ADC (nADC), as measured using MRI, can be used to predict the histopathological grade of azoospermia and to differentiate obstructive from non-obstructive azoospermia.}
}
@inproceedings{ISMRM2018_4589,
annote={ISMRM2018_4589},
pages={4589},
file={ISMRM2018_4589.pdf:ISMRM2018_4589.pdf:PDF},
title={Optimizing Diffusion-Weighted {MRI} of the Kidneys: Comparison between Simultaneous Multi-Slice and Integrated Slice-by-Slice Shimming Echo Planar Sequences},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4589.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Gumuyang ZHANG and Tianyi Qian and Bing Shi and Hailong Zhou and Alto Stemmer and Xiaoyan Peng and Yan Liu and Limeng Chen and Hao Sun and Huadan Xue and Zhengyu Jin},
abstract={This study aimed to evaluate the image quality and scan time of the simultaneous multi-slice (SMS) technique compared to integrated slice-by-slice shimming (iShim[MB1] ) single-shot echo planar imaging (ss-epi) for diffusion-weighted imaging (DWI) of the kidneys. Six healthy subjects and 22 patients with renal disease underwent both SMS and iShim DWI scans on a 3T MR scanner. Despite the average scan time of SMS DWI being decreased by 53.5\% compared to iShim DWI, the image quality of SMS DWI was slightly better, with a higher signal-to-noise ratio and similar contrast-to-noise ratio. ADC values of the kidneys were comparable in both DWI sequences. [MB1]Our product name is "SliceAdjust".}
}
@inproceedings{ISMRM2018_4590,
annote={ISMRM2018_4590},
pages={4590},
file={ISMRM2018_4590.pdf:ISMRM2018_4590.pdf:PDF},
title={Across vendor comparison of multi-echo {GRE} R2* measurements in the kidney and a tissue-mimicking phantom},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4590.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Pim Pullens and Hubert Raeymaekers},
abstract={BOLD MRI may serve as an indicator of blood oxygenation in the kidney and could potentially be used as a MRI biomarker in several kidney diseases. To be effective as a quantitative imaging biomarker, BOLD MRI must be an objective measure, independent of the MRI scanner model and MRI sequence implementation details. We have compared BOLD imaging across vendors in a tissue-mimicking phantom and in the healthy kidney by assessing R2* values in 12 concentric layers.}
}
@inproceedings{ISMRM2018_4591,
annote={ISMRM2018_4591},
pages={4591},
file={ISMRM2018_4591.pdf:ISMRM2018_4591.pdf:PDF},
title={T1ρ mapping for assessment of fibrosis in renal allografts.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4591.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Stefanie Hectors and Octavia Bane and Paul Kennedy and Fadi El Salem and Madhav Menon and Maxwell Segall and Rafael Khaim and Veronica Delaney and Sara Lewis and Bachir Taouli},
abstract={The goal of our study was to assess the utility of T
1ρ measurements for the differentiation between functional and fibrotic renal allografts. We observed a significant increase in T
1ρ in the cortex of fibrotic renal allografts compared to functional allografts. Our results show that T
1ρ may be a suitable biomarker for the assessment of fibrosis in renal allografts, which needs to be verified in a larger cohort of patients.}
}
@inproceedings{ISMRM2018_4592,
annote={ISMRM2018_4592},
pages={4592},
file={ISMRM2018_4592.pdf:ISMRM2018_4592.pdf:PDF},
title={Value of endovaginal {MRI} derived tumor volumes for predicting outcomes in patients selected for trachelectomy vs hysterectomy in cervical cancer},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4592.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Katja N De Paepe and Thomas E J Ind and Ayoma D Attygalle and Veronica A Morgan and Karen Thomas and Nandita M deSouza},
abstract={A pre-surgical endovaginal MRI was performed in 142 women with early stage cervical cancer scheduled for hysterectomy (n=43) or trachelectomy (n=99). Total tumor volume was calculated by summing MRI and LLETZ/biopsy (done prior to imaging) volumes. In the hysterectomy group, tumour volume, grade and lymphovascular space invasion (LVSI) differed significantly between those without and with an adverse outcome (need for adjuvant treatment or recurrence); only volume and LVSI were significant in the trachelectomy group where multivariate analysis demonstrated their independence. In patients eligible for trachelectomy, with tumors >1.4 cm
3 and with LVSI, administration of (neo)adjuvant treatment may potentially improve outcome.}
}
@inproceedings{ISMRM2018_4593,
annote={ISMRM2018_4593},
pages={4593},
file={ISMRM2018_4593.pdf:ISMRM2018_4593.pdf:PDF},
title={Feasibility of Renal {ASL} in a Paediatric Cohort with Impaired Renal Function},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4593.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Fabio Nery and Enrico De Vita and Chris A Clark and Isky Gordon and David L Thomas},
abstract={Arterial Spin Labelling (ASL) allows for non-invasive measurements of tissue perfusion. As such, it presents an attractive alternative to contrast-enhanced based methods for quantification of renal perfusion, particularly in populations with impaired renal function. In this work, we assess the feasibility of ASL in a paediatric cohort with severe kidney disease by combining a robust acquisition scheme with an optimised retrospective motion correction approach.}
}
@inproceedings{ISMRM2018_4594,
annote={ISMRM2018_4594},
pages={4594},
file={ISMRM2018_4594.pdf:ISMRM2018_4594.pdf:PDF},
title={Multiparametric {MRI} of Folic Acid Induced Renal Pathology in Mice: A Longitudinal Study},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4594.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Kai Jiang and Tristan A. Ponzo and Hui Tang and Prasanna K. Mishra and Slobodan I. Macura and Lilach O. Lerman},
abstract={Multiparametric MRI was used to assess folic acid-induced renal pathology in mice. Kidney volume, R
2*, magnetization transfer ratio (MTR), perfusion, T
1 and glomerular filtration rate (GFR) were measured at 2 and 4 weeks post-treatment. While kidney structure (volume and MTR) and hypoxia (R
2*) showed progressive deterioration, renal perfusion and normalized GFR dropped dramatically at 2 weeks but recovered slightly at 4 weeks. T
1 elevated at 2 weeks and slightly dropped at 4 weeks, suggesting development of transient edema. In conclusion, multiparametric MRI provides a valuable tool for investigation and monitoring of folic acid induced renal pathology.}
}
@inproceedings{ISMRM2018_4595,
annote={ISMRM2018_4595},
pages={4595},
file={ISMRM2018_4595.pdf:ISMRM2018_4595.pdf:PDF},
title={Tri- and Biexponential Diffusion Analyses of the Kidney: Effect of Respiratory Controlled Acquisition on Measurement Accuracy and Repeatability of Diffusion Parameters},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4595.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yuki Koshino and Naoki Ohno and Tosiaki Miyati and Naoki Hori and Yukihiro Matsuura and Toshifumi Gabata},
abstract={To investigate the effect of respiratory-controlled acquisition on intravoxel incoherent motion analysis in the kidney, we compared the fitting accuracy and repeatability of diffusion parameters with tri- and biexponential models among three different methods, ie., respiratory triggering, abdominal belt and free breathing. Respiratory triggering shows better fitting accuracy and repeatability of tri- and biexponential diffusion parameters compared with free breathing. Moreover, abdominal belt can improve the measurement repeatability even with free breathing.}
}
@inproceedings{ISMRM2018_4596,
annote={ISMRM2018_4596},
pages={4596},
file={ISMRM2018_4596.pdf:ISMRM2018_4596.pdf:PDF},
title={Multiparametric {MRI} Data in Diabetic Nephropathy: Correlation with e{GFR} and e{GFR}_slope},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4596.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Lu-Ping Li and Wei Li and Bradley Hack and Orly Kohn and Stuart Sprague and Pottumarthi Prasad},
abstract={BOLD, Diffusion and ASL MRI are useful in the evaluation of renal oxygenation, fibrosis and blood flow. In this study, these three functional MRI data were acquired in patients with diabetic nephropathy (DN) patients and stage-3 chronic kidney disease (CKD). For the first time, we report that the cortical blood flow and response to furosemide in renal medulla are significantly correlated with yearly rate of change in eGFR. These relationships were independent of any correlations observed with eGFR. The correlations with eGFR seem to depend on whether a control group was included.}
}
@inproceedings{ISMRM2018_4597,
annote={ISMRM2018_4597},
pages={4597},
file={ISMRM2018_4597.pdf:ISMRM2018_4597.pdf:PDF},
title={Preliminary study of evaluating Intrarenal Oxygenation in Iodinated Contrast-Induced Acute Kidney- Injured pig models by {BOLD} {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4597.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Junjie Ren and Shengzhang Ji and Zhizheng Zhuo and Chenjie An},
abstract={Iodinated contrast agent (CA) is important for many radiologic and interventional procedures. However, contrast-induced acute kidney injury (CIAKI) is potentially life-threatening, especially for patients with impaired renal function and it has become one of the leading causes of hospital-acquired acute kidney injury (AKI)
[1] . The pathogenesis of CIAKI is not yet fully understood, but the relevance of renal medullary hypoxia in the pathophysiology of AKI is well accepted. In recent years, many studies focused on the change of intrarenal oxygenation and showed renal hypoxia especially in medulla. Blood oxygen level dependent magnetic resonance imaging (BOLD MRI) is a noninvasive method that can assess hypoxia by utilizing the endogenous contrast generated by paramagnetic deoxyhemoglobin
[2] .}
}
@inproceedings{ISMRM2018_4598,
annote={ISMRM2018_4598},
pages={4598},
file={ISMRM2018_4598.pdf:ISMRM2018_4598.pdf:PDF},
title={Effect of orally administered aspirin on renal function in hypertensive rats},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4598.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Greg O. Cron and Rafael Glikstein and Jean-François Thibodeau and Anthony Carter and Naomi C. Boisvert and Chet E. Holterman and Lihua Zhu and Chris Kennedy},
abstract={Although aspirin and other NSAIDs are commonly perceived as harmless, they may be dangerous for hypertensive patients. We recently showed that in hypertensive mice, genetic suppression of the renal vessel EP4 receptor (which mimics downstream effects of NSAIDs) leads to a massive reduction in renal perfusion. However, direct genetic manipulation of a drug end target is not the same thing as actually administering the drug. Thus, we repeated that study, this time giving aspirin instead of using genetic manipulation. Hypertensive rats that drank aspirin water suffered severe kidney damage and 2/5 died. For hypertensive patients, NSAIDs warrant extreme caution.}
}
@inproceedings{ISMRM2018_4599,
annote={ISMRM2018_4599},
pages={4599},
file={ISMRM2018_4599.pdf:ISMRM2018_4599.pdf:PDF},
title={Analysis of kidney function and therapy monitoring with {DCE}-{MRI} in a murine model of septic shock},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4599.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Claudia Weidensteiner and Wilfried Reichardt and Joachim Struck and Anne Kirchherr and Katja Wagner and Florian Wagner and Dominik von Elverfeldt},
abstract={DCE-MRI with a 3D spoiled gradient echo sequence and injection of Gd-DTPA was used to analyze the kidney function in mice during septic shock (cecal ligation and puncture CLP model). Gd concentration time courses were analyzed without pharmacokinetic modelling. In renal cortex and medulla of septic mice a slower exponential decay compared to baseline or even non-exponential curve shapes were observed. In most septic mice there was no Gd accumulation in the urine in the bladder. Treatment with an antibody targeting adrenomedullin (a vasodilatory peptide) resulted in a faster half-life of tracer elimination in the kidneys compared to vehicle-treatment.}
}
@inproceedings{ISMRM2018_4600,
annote={ISMRM2018_4600},
pages={4600},
file={ISMRM2018_4600.pdf:ISMRM2018_4600.pdf:PDF},
title={Assessment of Optimal Technique for Measurement of Medullary Perfusion},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4600.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Chris R Bradley and Charlotte E Buchanan and Eleanor F Cox and Susan T Francis},
abstract={The ability to assess medullary perfusion is important in kidney disease, for example in acute kidney injury (AKI) in which reduced medullary blood flow is implicated. In this study, we compare the use of a spin echo (SE) EPI and balanced FFE (bFFE) readout at multiple post label delay (PLD) times to determine the optimal readout scheme and to assess the number of ASL pairs required to compute medullary perfusion. Using a bFFE FAIR ASL scheme, it is possible to quantify tissue perfusion within the renal medulla.}
}
@inproceedings{ISMRM2018_4601,
annote={ISMRM2018_4601},
pages={4601},
file={ISMRM2018_4601.pdf:ISMRM2018_4601.pdf:PDF},
title={T2{WI} Texture Analysis in Renal Cell Carcinoma: Histologic Subtype Classification},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4601.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Zhenhao Liu and Haiyi Wang and Xu Bai and Huiling Yi and Huiyi Ye},
abstract={This retrospective study investigates the possibility of distinguishing between clear cell renal cell carcinoma ( ccRCC ) and non-clear cell renal cell carcinoma ( nccRCC ) using MRI-derived parameters by exploring a predictive method. We enrolled the patients with three common subtypes of renal tumor - clear cell renal cell carcinoma ( ccRCC ), papillary renal cell carcinoma ( pRCC ) and chromophobic renal cell carcinoma ( cRCC ). We combined pRCC and cRCC into one subtype - nccRCC. Our results demonstrated that MRI texture analysis can differentiate ccRCC from nccRCC with high specificity, sensitivity and accuracy and can probably facilitate the precise treatment of renal tumors in the future clinical practice.}
}
@inproceedings{ISMRM2018_4602,
annote={ISMRM2018_4602},
pages={4602},
file={ISMRM2018_4602.pdf:ISMRM2018_4602.pdf:PDF},
title={A comparison of 7 and 3 Tesla time-of-flight renal {MR} angiography for detection of intrarenal vessels},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4602.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Emma Doran and Stephen Bawden and Christopher Mirfin and Paul Glover and Richard Bowtell and Penny A. Gowland and Susan Francis},
abstract={Chronic Kidney Disease (CKD) is thought to be due to small artery disease at the cortico-medullary border, however these vessels are too small to be imaged at conventional field strengths. Here, we assess the feasibility of 2D gradient echo Time-of-flight (TOF) renal angiography at 7 T to detect the arterial vasculature of the kidney and delineate the intrarenal vasculature network. We compare TOF MRA data collected at 3 T and 7 T in the same subjects and illustrate the superiority of 7 T for high spatial resolution MRA.}
}
@inproceedings{ISMRM2018_4603,
annote={ISMRM2018_4603},
pages={4603},
file={ISMRM2018_4603.pdf:ISMRM2018_4603.pdf:PDF},
title={Effects of anesthesia on renal function and metabolism in rats},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4603.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Haiyun Qi and Christian Østergaard Mariager and Jakob Lindhardt and Per Mose Nielsen and Hans Stødkilde-Jørgensen and Christoffer Laustsen},
abstract={Performing MRI of animals typically requires anesthesia. However, anesthesia is known to modulate a wide variety of important metabolic and functional processes and as such represents potential limitations in study design. Here we investigated renal functional and metabolic consequences of three typical rodent anesthetics of sevoflurane, inactin and a mixture of fentanyl, fluanisone and midazolam (FFM), with hyperpolarized [1-
13C] pyruvate MRI and DCE imaging. FFM increased renal lactate/pyruvate ratio and blood lactate concentration. Inactin and sevoflurane had reasonable renal metabolism and function. The results indicate inactin and sevoflurane are preferable when renal metabolism and function are the consideration of research.
}
}
@inproceedings{ISMRM2018_4604,
annote={ISMRM2018_4604},
pages={4604},
file={ISMRM2018_4604.pdf:ISMRM2018_4604.pdf:PDF},
title={Combined hepatocellular-cholangiocarcinoma: diagnostic and prognostic values of {LI}-{RADS} v2017 categorization on gadoxetic acid-enhanced {MR} imaging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4604.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Sun Kyung Jeon and Ijin Joo and Dong Ho Lee and Sang Min Lee and Hyo Jin Kang and Jeong Min Lee},
abstract={Our retrospective study investigated the utility of Liver Imaging Reporting and Data System (LI-RADS) v2017 for combined hepatocellular cholangiocarcinoma (cHCC-CCs) in the differential diagnosis from HCCs and prediction of prognosis. Using LI-RADS on gadoxetic acid-enhanced MRI, among cHCC-CCs (n=70), 61.4\% (43/70) were accurately categorized as LR-M (probable malignancy, not specific for HCC) while 37.1\% (26/70) as LR-5/4 (definitely/probably HCC); among HCCs (n=70), 88.6\% (62/70) and 10.0\% (7/70) were categorized as LR-5/4 and LR-M, respectively. After surgical resection, patients with LR-M cHCC-CCs showed a higher early recurrence rate (≤6 months) than those with LR-5/4 cHCC-CCs (27.8\% (10/36) vs. 4.8\% (1/21), P=0.041).}
}
@inproceedings{ISMRM2018_4605,
annote={ISMRM2018_4605},
pages={4605},
file={ISMRM2018_4605.pdf:ISMRM2018_4605.pdf:PDF},
title={Preoperative Prediction of Microvascular Invasion in Hepatocellular Carcinoma Using Radiomic Analysis of Diffusion-weighted {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4605.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Xiangtian Zhao and Qiang Gao and Jingliang Cheng},
abstract={Microvascular invasion (MVI) in hepatocellular carcinoma (HCC) is an independent predictor of poor outcomes subsequent to surgical resection or liver transplantation (LT); however, MVI currently cannot be reliably determined preoperatively. In this study, we investigated the association between radiomic features on preoperative ADC maps and the MVI (with or without) in resected 96 HCCs. Furthermore, we employed machine-learning methods and independently evaluated their prediction performance. Total 1029 radiomic features were extracted from cancerous VOIs on ADC maps of each patient. Finally, 7 features could differentiate HCCs with MVI versus HCCs without. The random forest classifier using the optimal feature subset achieved the best performance, with an area under the receiver operating characteristic curve 0.79, sensitivity 71.0\%, specificity 85.0\%, precision 73\% and recall 70\%.}
}
@inproceedings{ISMRM2018_4606,
annote={ISMRM2018_4606},
pages={4606},
file={ISMRM2018_4606.pdf:ISMRM2018_4606.pdf:PDF},
title={{MDCT} outperforms gadoxetate-enhanced {MRI} in differentiating stroma-rich tumors from hepatocellular carcinomas developing in patients with chronic liver diseases},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4606.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Kengo Yoshimitsu},
abstract={Consecutive 179 patients with chronic liver diseases who underwent gadoxetate enhanced-MRI and MDCT firstly developed hypervascular liver masses were retrospectively recruited and 14 stroma-rich tumors (SRT), such as intrahepatic cholangiocellular carcinoma and 165 hepatocellular carcinoma (HCC) were found. Using rim enhancement and target sign on DWI, which were confirmed to favor SRT over HCC by multivariate analysis on gadoxetate-enhanced MRI, 71\% sensitivity and 97\% specificity were obtained, however, MDCT provided almost 100\% accuracy when delayed or prolonged enhancement was considered signs suggesting SRT. For diagnosing SRT, MDCT outperforms gadoxetate-enhanced MRI.}
}
@inproceedings{ISMRM2018_4607,
annote={ISMRM2018_4607},
pages={4607},
file={ISMRM2018_4607.pdf:ISMRM2018_4607.pdf:PDF},
title={An automated lesion detection method on hepatic hemangioma and hepatic cyst using fully convoluted network},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4607.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yajing Zhang and Mo Shen and Yin Guo and Huiyu Qiao and Qian Jiang and Sussi Wang and Yi Yang},
abstract={Hepatic hemangioma and hepatic cyst are two kinds of common benign liver diseases. MR has been widely used for their diagnosis due to its significance of detection on small lesions. This study proposes a deep learning based method to detect the lesion of hemangioma and cyst on MR dynamic contrast-enhanced images. The results show good alignment of automated detection boundary with the actual lesion boundary for both lesion types.}
}
@inproceedings{ISMRM2018_4608,
annote={ISMRM2018_4608},
pages={4608},
file={ISMRM2018_4608.pdf:ISMRM2018_4608.pdf:PDF},
title={High Acceleration Three Dimensional T1-weighted Dual Echo Dixon Imaging using Compressed Sensing-{SENSE}: Comparison of Image Quality and Solid Lesion Detectability with the Standard T1-Weighted Sequence},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4608.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ju Gang Nam and Jeong Min Lee and Sang Min Lee and Hyo-Jin Kang and Eun Sun Lee and Bo Yun Hur and Jeong Hee Yoon and EunJu Kim and Mariya Doneva},
abstract={A total of 163 consecutive patients underwent gadoxetic acid-enhanced liver MRI at 3T with two HBP protocols using the standard mDIxon-3D-GRE technique with sensitivity-encoding method (SENSE; acceleration factor (AF): 2.8, standard mDixon-GRE) and a high acceleration mDIxon-3D GRE technique using the combined compressed sensing (CS)-SENSE technique (CS-SENSE mDixon-GRE). The consensus reading revealed no significant difference in overall image quality. CS-SENSE mDixon-GRE showed higher image noise, but less motion artifact and overall artifact levels. In terms of lesion detection, reader-averaged JAFROC figures-of-merit showed non-inferior performance of CS-SENSE mDixon-GRE over standard mDixon-GRE was confirmed (JAFROC figure-of-merits difference: 0.064 [-0.012, 0.081])}
}
@inproceedings{ISMRM2018_4609,
annote={ISMRM2018_4609},
pages={4609},
file={ISMRM2018_4609.pdf:ISMRM2018_4609.pdf:PDF},
title={Diagnostic Accuracy of Liver Imaging Reporting and Data System 2017 ({LIRADS}) Criteria for Hepatocellular Carcinoma},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4609.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Andrea Siobhan Kierans and Jasnit S. Makkar and Joshua Cornman-Homonoff and Preethi Guniganti and Elizabeth M Hecht},
abstract={The aim of our investigation is to assess the diagnostic accuracy of the LI-RADS 2017 criteria at two institutions using multiple readers with varying levels of experience with explant or imaging follow-up as the reference standard. Radiology databases from two academic institutions were searched (2013-2014) for patients with a clinical diagnosis of chronic liver disease and at least one reported hepatic observation on dynamic contrast enhanced CT or MRI. This yielded a final cohort of 103 patients with 141 hepatic observations. Two radiologists reviewed the imaging independently and assigned a LI-RADs category to each observation. Inter-reader reliability for LI-RAD assessment was moderate (ICC = 0.63). Sensitivity of LI-RADs categorization for diagnosing HCC was 62\% and 59\% and specificity was 96\% and 84\% for reader 1 and 2 respectively. LI-RADs categorization using gadoxetate disodium MR demonstrated higher specificity for HCC diagnosis for reader 2, than MR with extracellular agent.}
}
@inproceedings{ISMRM2018_4610,
annote={ISMRM2018_4610},
pages={4610},
file={ISMRM2018_4610.pdf:ISMRM2018_4610.pdf:PDF},
title={Changes in {HCC} tumor stiffness post 90Yttrium radioembolization assessed with {MR} elastography: Early results.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4610.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Paul Kennedy and Sara Lewis and Octavia Bane and Stefanie Hectors and Maxwell Segall and Edward Kim and Bachir Taouli},
abstract={The goal of the current study was to assess the changes in hepatocellular carcinoma (HCC) stiffness using 2D MR elastography (MRE) at baseline and 6 weeks after
90Yttrium radioembolization (RE). Preliminary results are presented in 10 patients and show that HCC stiffness and liver stiffness adjacent to the treated lesion are both significantly increased 6w after therapy. Percentage change in tumor stiffness is significantly correlated with degree of tumor necrosis at 6w.}
}
@inproceedings{ISMRM2018_4611,
annote={ISMRM2018_4611},
pages={4611},
file={ISMRM2018_4611.pdf:ISMRM2018_4611.pdf:PDF},
title={Diffusion Kurtosis Imaging for Assessing the Therapeutic Response of Transcatheter Arterial Chemoembolization in Hepatocellular Carcinoma},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4611.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Zhenguo Yuan and Mengying Xia and Weibo Chen},
abstract={Hepatocellular carcinoma (HCC) is one of the major causes of morbidity and mortality in patients with chronic liver disease. Transcatheter arterial chemoembolization (TACE) play an important role in treatment for HCC. Evaluation of the response to TACE treatment affects not only the therapeutic efficacy but also the treatment plan. Data from 43 patients with hepatic cancer between January 2017 and September 2017 were recruited for this study. Magnetic resonance imaging (MRI) and DKI (b=0, 800, 1500, 2000 mm
2/s) were performed before and 3 weeks after initiating TACE. Contrast-enhanced MRI was performed 3 months and 6 months after initiating TACE. We observed a significant decrease in MK in HCC tissues that were completely necrotic after TACE. The MK value can reflect the complexity of tissue structure. A lower MK value indicates evidence of necrosis, implying more stable lesions and hence better treatment outcomes. Therefore, the differences in MK values observed in our study reflected the differences in tissue microstructural complexity between the progressing and non-progressing groups. The change of MK values before and after TACE can thus be used to estimate the degree of tumor necrosis and to further evaluate the effect of interventional therapy.}
}
@inproceedings{ISMRM2018_4612,
annote={ISMRM2018_4612},
pages={4612},
file={ISMRM2018_4612.pdf:ISMRM2018_4612.pdf:PDF},
title={Contrast-enhanced {MR} Imaging 3D texture analyses as a potential tool for preoperative prediction of microvascular invasion in hepatocellular carcinoma: Comparison with postoperative pathology},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4612.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yongjian Zhu and Xiaohong Ma and Xinming Zhao and Bing Feng and Lizhi Xie},
abstract={Microvascular invasion (MVI) is a significant risk factor contributing to high recurrence ratio and poor prognosis of hepatocellular carcinoma (HCC). Therefore, it is of great clinical significance to accurately predict MVI of HCC preoperatively. Texture analyses (TA) is a novel image post-processing technique, which analyze the distribution and associations of pixel intensities in images with a series of quantitative texture parameters. However, there was limited report on applying TA on MVI of HCC . The purpose of this study was to explore the value of contrast enhanced MRI texture analyses in the preoperative prediction of MVI of HCC preoperative.}
}
@inproceedings{ISMRM2018_4613,
annote={ISMRM2018_4613},
pages={4613},
file={ISMRM2018_4613.pdf:ISMRM2018_4613.pdf:PDF},
title={Using deep learning to investigate the value of diffusion weighted images for malignancy characterization of hepatocellular carcinoma},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4613.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Wu Zhou and Qiyao Wang and Changhong Liang and Hairong Zheng and Lijuan Zhang},
abstract={The apparent diffusion coefficient (ADC) derived from Diffusion-weighted imaging (DWI) has been widely used for lesion characterization. However, ADC is calculated from image intensities with different b values, which is a low-level image feature that might be insufficient to represent heterogeneous of neoplasm. Furthermore, ADC measurements are subject to the influence of motion and image artifacts. The deep feature based on the emerging deep learning technique has been considered to be superior to traditional low-level features. The purpose of this study is to effectively characterize the malignancy of HCC based on deep feature derived from DWI data using deep learning.}
}
@inproceedings{ISMRM2018_4614,
annote={ISMRM2018_4614},
pages={4614},
file={ISMRM2018_4614.pdf:ISMRM2018_4614.pdf:PDF},
title={Discriminative deep feature fusion of Contrast-enhanced {MR} for malignancy characterization of hepatocellular carcinoma},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4614.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Wu Zhou and Tianyou Dou and Miaoyun Zhangwen and Hui Ye and Dong Cao and Honglai Zhang and Changhong Liang and Hairong Zheng and Lijuan Zhang},
abstract={The malignancy of hepatocellular carcinoma (HCC) is of great significance to prognosis. Recently, deep feature in the arterial phase of Contrast-enhanced MR has been shown to be superior to texture features for malignancy characterization of HCCs. However, only arterial phase was used for deep feature extraction, ignoring the impact of other phases in Contrast-enhanced MR for malignancy characterization. In this work, we design a discriminative multimodal deep feature fusion framework to both extract correlation and separation of deep features between Contrast-enhanced MR images for malignancy characterization of HCC, which outperforms the simply concatenation and the recently proposed deep correlation model.}
}
@inproceedings{ISMRM2018_4615,
annote={ISMRM2018_4615},
pages={4615},
file={ISMRM2018_4615.pdf:ISMRM2018_4615.pdf:PDF},
title={Late gadolinium {MRI} hyperintensity of colorectal liver metastases with extracellular contrast agents (gadobutrol) versus intravascular contrast agents (gadofosveset)},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4615.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Helen Cheung and Natalie Coburn and Paul J Karanicolas and Calvin Law and John M Hudson and Laurent Milot},
abstract={Late gadolinium hyperintensity (LGH) of colorectal liver metastases (CRCLM) using MRI with extracellular contrast agents presents a diagnostic dilemma that is commonly encountered clinically because it can be difficult to distinguish from benign hemangiomas. CRCLM may demonstrate less LGH using MRI with intravascular contrast agents due to reduced retention of contrast within these lesions. Approximately half of CRCLM demonstrate LGH on MRI with extracellular contrast agents versus only 6\% on MRI with intravascular contrast agents. LGH is significantly better at excluding malignancy in patients with intravascular agents compared with extracellular contrast agents and may be a clinically useful problem-solving tool.}
}
@inproceedings{ISMRM2018_4616,
annote={ISMRM2018_4616},
pages={4616},
file={ISMRM2018_4616.pdf:ISMRM2018_4616.pdf:PDF},
title={High-b Fast Advanced Spin Echo Diffusion-Weighted Imaging in the Abdomen},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4616.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Takeshi Yoshikawa and Katsusuke Kyotani and Yoshiharu Ohno and Yoshimori Kassai and Masao Yui and Eiji Takeda and Shinichiro Seki and Yuji Kishida},
abstract={High-b FASE-DWI can improve image quality and decrease image distortion without hampering abdominal lesion detection and ADC measurement.}
}
@inproceedings{ISMRM2018_4617,
annote={ISMRM2018_4617},
pages={4617},
file={ISMRM2018_4617.pdf:ISMRM2018_4617.pdf:PDF},
title={Multiband {SENSE} accelerated diffusion weighted imaging of the abdomen with {CAIPIRINHA}: Preliminary study on clinical applicability},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4617.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yi Wang and Tyson Nunn and Noah Briller and Carolyn Wang and Sooah Kim},
abstract={DWI is rapidly becoming a modality of choice to detect, characterize and monitor malignant lesions. Although diffusion imaging has benefited greatly from multiband imaging in the brain, investigation on abdomen DWI using MB has been limited. The purpose of this study was to examine the feasibility of MB-SENSE for abdominal DWI. The study demonstrated that MB-SENSE can be used to accelerate abdominal DWI with drastically reduced acquisition time (~50\%) without having a significant impact on image quality. Though, refinement of the MB-SENSE free-breathing single-shot EPI sequence is necessary to ascertain the clinical value of MB-SENSE in DWI for the abdomen.}
}
@inproceedings{ISMRM2018_4618,
annote={ISMRM2018_4618},
pages={4618},
file={ISMRM2018_4618.pdf:ISMRM2018_4618.pdf:PDF},
title={Comparison of Referenceless Methods for {EPI} Ghost Correction in Breast Diffusion Weighted Imaging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4618.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jessica A McKay and Steen Moeller and Lei Zhang and Edward J Auerbach and Michael T Nelson and Patrick J Bolan},
abstract={Three-line navigator correction of Nyquist ghosts in spin-echo echo-planar imaging (SE-EPI) diffusion weighted imaging (DWI) often fails in body imaging. Several alternative strategies have been proposed including referenceless methods, which do not require any type of reference information but instead minimize a cost function based on the data itself. The purpose of this work is to assess ghost correction of undersampled (R=3) breast DWI using several referenceless methods, including minimization of SVD in k-space, image entropy, a ghost/object ratio of the image and a combination. All four referenceless strategies outperform the standard navigator correction, providing higher quality images and unbiased ADC maps.}
}
@inproceedings{ISMRM2018_4619,
annote={ISMRM2018_4619},
pages={4619},
file={ISMRM2018_4619.pdf:ISMRM2018_4619.pdf:PDF},
title={Repeatability of Apparent Diffusion Coefficient measurements using Simultaneous Multi-slice Diffusion-Weighted imaging with elastic in-plane motion correction: a Comparison with Conventional {DWI} in Healthy Liver Parenchyma},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4619.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jia Xu and Xuan Wang and Tianyi Qian and Shitian Wang and Huadan Xue and Zhengyu Jin},
abstract={The simultaneous multi-slice (SMS) technique allows reducing the scan time of DWI without significant compromises in image quality. An adequate test-retest reliability of apparent diffusion coefficient (ADC) is essential for clinical use. The aim of this study was to prospectively compare the ADC value and test-retest repeatability of SMS-DWI with elastic in-plane motion correction in comparison to conventional DWI in healthy liver parenchyma. SMS-DWI and motion corrected SMS-DWI images (Moco-SMS) demonstrated significantly higher ADC values than conventional DWI in almost all liver regions. Moco-SMS showed significantly higher test-retest repeatability than conventional DWI in regions close to liver edges.}
}
@inproceedings{ISMRM2018_4620,
annote={ISMRM2018_4620},
pages={4620},
file={ISMRM2018_4620.pdf:ISMRM2018_4620.pdf:PDF},
title={{CNN} based Super-Resolution of Intravoxel Incoherent Motion Imaging for Liver},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4620.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jiqing Huang and Jin Qin and Lihui Wang and Rongpin Wang and Zi-Xiang Kuai and Chen Ye and Tianye Wang and Yuemin Zhu},
abstract={We investigated the super-resolution reconstruction method for IVIM imaging based on convolution neural networks (CNN). Three-layers-CNN was constructed and trained firstly with a series of paired low- and high-resolution images and then the super-resolution IVIM images were reconstructed with such network, the reconstruction quality was evaluated finally in terms of PSNR, SSIM, diffusivity, perfusion fraction and pseudo-diffusivity respectively. The results show that the CNN-based super resolution reconstruction for IVIM has a great performance and may enable IVIM to be analyzed with unprecedent resolution.}
}
@inproceedings{ISMRM2018_4621,
annote={ISMRM2018_4621},
pages={4621},
file={ISMRM2018_4621.pdf:ISMRM2018_4621.pdf:PDF},
title={Comparison of Slice-specific Shim and Volume Shim for 1.5T Whole-body Diffusion Weighted Imaging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4621.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Sarah McElroy and Jessica M Winfield and Radhouene Neji and Alto Stemmer and Kiefer Berthold and Joanna Bell and John Spence and Geoff Charles-Edwards and Olwen Westerland and Vicky Goh},
abstract={This study compared whole body diffusion weighted MR imaging (WB-DWI) acquired on a 1.5T scanner with and without integrated slice-specific shimming with retrospective distortion correction (iShim) for evaluation of monoclonal plasma cell disorders. WB-DWI with iShim showed significant reduction of the spinal displacement artefact and increased signal in the sternum.}
}
@inproceedings{ISMRM2018_4622,
annote={ISMRM2018_4622},
pages={4622},
file={ISMRM2018_4622.pdf:ISMRM2018_4622.pdf:PDF},
title={Toward quantification of renal tubular volume fraction using diffusion-weighted split-echo {RARE} in conjunction with a three-compartment {IVIM} model},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4622.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Joao Periquito and Katharina Paul and Till Huelnhagen and Yiyi Ji and Min-Chi Ku and Sarah Brix and Kathleen Cantow and Erdmann Seeliger and Bert Flemming and Thomas Gladytz and Dirk Grosenick and Andreas Pohlmann and Thoralf Niendorf},
abstract={T
2* mapping does not fully represent renal tissue oxygenation. Diffusion-weighted imaging (DWI) can provide information about confounding factors such as tubular volume fraction, which can be used to correct T
2*. By using a three compartment IVIM model, tubular volume fraction can be mapped with DWI. The most widely used DWI technique is spin-echo EPI which is sensitive to magnetic field inhomogeneities and hence prone to geometric distortions. In this work we propose a diffusion-weighted Rapid Acquisition Relaxation Enhancement (RARE) variant for DWI of the rat kidney free of geometric distortions to quantify tubular volume fraction at 9.4 Tesla.}
}
@inproceedings{ISMRM2018_4623,
annote={ISMRM2018_4623},
pages={4623},
file={ISMRM2018_4623.pdf:ISMRM2018_4623.pdf:PDF},
title={Robustness of diffusion-prepared 3D {TSE} for isotropic-resolution large-{FOV} coronal {DWI} of neurogenic tumors in cervical and pelvic regions},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4623.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Barbara Cervantes and Alexandra Gersing and Benedikt Schwaiger and Andreas Hock and Johannes M. Peeters and Carolin Knebel and Klaus Wörtler and Dimitrios Karampinos},
abstract={DWI of musculoskeletal tumors has been proposed as a non-invasive tool of potential valuable diagnostic utility. Large-FOV isotropic-resolution DWI can provide improved visualization of MSK tumors but deems particularly challenging for conventionally used DW-EPI in terms of geometric distortions and chemical-shift artifacts. 3D DW-TSE techniques can alleviate these challenges and have been shown to be useful in DWI of different body regions. The present work examines the robustness to distortions and artifacts of 3D DW-TSE in isotropic-resolution large-FOV coronal DWI of neurogenic tumors in two anatomical regions where DW-EPI is highly prone to distortion artifacts.}
}
@inproceedings{ISMRM2018_4624,
annote={ISMRM2018_4624},
pages={4624},
file={ISMRM2018_4624.pdf:ISMRM2018_4624.pdf:PDF},
title={Variable-{TE} {STIR} computed Diffusion Weighted Imaging Technique for the abdomen},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4624.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Hiroshi Kusahara and Yuki Takai and Yoshimori Kassai},
abstract={In this study to the authors adapted the variable-TE cDWI (vTE-cDWI) technique to the abdominal region, using ADC map, T2 map and T1 map with IR-based images. The algorithm under evaluation allows computing diffusion images for arbitrary combinations of TE, b-value and TI based on four acquisitions (4-points method). This technique was shown to generate STIR-cDWI with higher SNR compared to the acquired STIR-DWI, as well as obtain ADC maps and T1 maps with optimal TI for any arbitrary tissue. The clinical benefits of the method and the preliminary results on volunteers are discussed.}
}
@inproceedings{ISMRM2018_4625,
annote={ISMRM2018_4625},
pages={4625},
file={ISMRM2018_4625.pdf:ISMRM2018_4625.pdf:PDF},
title={Computed {DWI} for breast cancer detection: improved fat suppression and lesion-to-background contrast with a novel low {ADC} pixel cut-off technique},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4625.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Toshiki Kazama and Taro Takahara and Tetsu Niwa and Jun Endo and Hiroshi Yamamuro and Tatsuya Sekiguchi and Jun Hashimoto and Thomas Kwee and Yutaka Imai},
abstract={When we calculate very high b-value images using computed diffusion-weighted imaging (cDWI), a tremendous number of bright pixels (noise) appears on the images and they disturb the visualization of lesions. Bright noise on high b-value images may be suppressed by cutting off pixels with very low ADC values. Because the ADC of fat is very low, unsuppressed fat signal can be deleted using the same technique. With appropriate use of the low ADC pixel cut-off technique on cDWI, diagnostic performance of cDWI of the breast may be improved.}
}
@inproceedings{ISMRM2018_4626,
annote={ISMRM2018_4626},
pages={4626},
file={ISMRM2018_4626.pdf:ISMRM2018_4626.pdf:PDF},
title={Prediction of treatment response based on baseline volumetric functional {MR} imaging criteria in patients with unresectable {HCC} who are candidate for Trans-Arterial Chemoembolization.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4626.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Mounes Aliyari Ghasabeh and Ankur Pandey and Sanaz Ameli and Pallavi Pandey and pegah Khoshpouri and Yan luo and Farnaz Najmi varzaneh and Manijeh Zargham pour and Ihab R. Kamel},
abstract={Synopsis: Predicting overall survival in HCC patients before initiating treatment is essential to personalize a treatment plan for each patient. Barcelona clinic liver cancer (BCLC) is one of the current criteria for predicting pre-therapeutic overall survival (OS). Several studies suggested a valuable role of functional MRI biomarkers including diffusion-weighted imaging (DWI) with apparent diffusion coefficients (ADC), tumor venous enhancement (VE) and tumor volume (TV) in tumor response assessment. These metrics rely on changes post therapy; none of these parameters assessed baseline values of these variables in predicting OS before starting treatment.}
}
@inproceedings{ISMRM2018_4627,
annote={ISMRM2018_4627},
pages={4627},
file={ISMRM2018_4627.pdf:ISMRM2018_4627.pdf:PDF},
title={Magnetic resonance imaging features of parenchymal mass with tumor in vein in patients with cirrhosis},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4627.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Saya Igarashi and Adrija Mamidipalli and Carolina Constantino and Atsushi Higaki and Mohanad Alhumayed and Jonathan Hooker and Chul Park and Claude B. Sirlin},
abstract={The purpose of this study is to determine in cirrhotic patients the proportion of MRI-diagnosed TIV cases with parenchymal masses, the proportion of cases due to HCC or non-HCC malignancy and whether assessment of the parenchymal mass allows differentiation of the malignancy type. All TIV cases had parenchymal masses. Using a composite reference standard and excluding tumors with no reference standard, the underlying malignancy was HCC in 91\% (41/45), ICC in 4\% (2/45) and H-ChC in 4\% (2/45). LI-RADS categorization of the parenchymal mass may help identify patients in whom TIV is not due to HCC. In particular, patients with TIV and LR-M parenchymal masses may need biopsy to exclude non-HCC malignancy.
}
}
@inproceedings{ISMRM2018_4628,
annote={ISMRM2018_4628},
pages={4628},
file={ISMRM2018_4628.pdf:ISMRM2018_4628.pdf:PDF},
title={Age-modulated changes in cerebrovascular reactivity after a single bout of exercise in young adults},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4628.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jessica J. Steventon and Catherine Foster and Daniel Helme and Kevin Murphy},
abstract={Exercise is a potent trigger for both neurogenesis and vascular plasticity yet the underlying temporal dynamics are not known. We aimed to test whether a single 20-minute bout of aerobic exercise was sufficient to induce changes in cerebrovascular reactivity (CVR) to carbon dioxide in young healthy adults using a dual-echo pulsed ASL sequence with a hypercapnia challenge. We show that age modulates the change in CVR following exercise and strongly predicts baseline CVR, independent of resting physiology and fitness. Our findings motivate the further exploration of the role of age in exercise-induced vascular plasticity.}
}
@inproceedings{ISMRM2018_4629,
annote={ISMRM2018_4629},
pages={4629},
file={ISMRM2018_4629.pdf:ISMRM2018_4629.pdf:PDF},
title={Investigation of the relationship between grey matter volume and cerebrovascular reactivity in aging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4629.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Claudine Joëlle Gauthier and Dalia Sabra and Brittany Intzandt and Arno Villringer and Richard D. Hoge and Christopher J. Steele},
abstract={Cerebrovascular reactivity (CVR) is decreased in aging and disease and is thought to reflect vascular health in the brain. Here, we explore the relationship between grey matter volume (GMV) and CVR in healthy younger and older adults. Results show that this relationship is more complex than previously thought, with a positive relationship between CVR and GMV when GMV is low, but a negative relationship at high GMVs both in younger and older adults. Future analyses will explore the role of cerebral blood flow in this relationship.}
}
@inproceedings{ISMRM2018_4630,
annote={ISMRM2018_4630},
pages={4630},
file={ISMRM2018_4630.pdf:ISMRM2018_4630.pdf:PDF},
title={Physiology of {CO}2 and neurovascular coupling: the impact of cerebrovascular reserve on Blood-Oxygenation-Level-Dependent functional {MRI} measurements},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4630.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Marco Piccirelli and Christiaan van Niftrik and Oliver Bozinov and Nicolai Maldaner and Catherine Strittmatter and Athina Pangalu and Antonios Valavanis and Luca Regli and Jorn Fierstra},
abstract={We investigate the effect of a general resting state of 40mmHg CO2 as compared to a physiological resting state on BOLD fMRI cerebrovascular reactivity and task based finger-tapping measurements in healthy subjects. We found that BOLD CVR and fMRI activation are significantly lower when measured at a set ‘‘isocapnic’’ baseline then at the physiological resting CO2. Our second finding is that fMRI signal changes significantly correlates to CVR and both measurements are similarly affected.}
}
@inproceedings{ISMRM2018_4631,
annote={ISMRM2018_4631},
pages={4631},
file={ISMRM2018_4631.pdf:ISMRM2018_4631.pdf:PDF},
title={Contribution of Systemic Vascular Effects on White Matter {BOLD} f{MRI} Signal},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4631.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Pinar S Özbay and Catie Chang and Dante Picchioni and Hendrik Mandelkow and Thomas Moehlman and Miranda Chappel-Farley and Peter van Gelderen and Jacco A de Zwart and Jeff H Duyn},
abstract={To probe a potential physiological mechanism behind reported BOLD fMRI signals in white matter (WM), we compared pulse-oximetry signals measured from finger-tip photo-plethysmography (PPG) with fMRI signals recorded simultaneously during an overnight sleep study. Intermittent amplitude (AMP) drops were observed during which WM signal increased and grey matter signal decreased. These findings point to a systemic vascular contribution to WM fMRI signals, driven by AMP drops and possibly linked to fluctuations in arousal state.}
}
@inproceedings{ISMRM2018_4632,
annote={ISMRM2018_4632},
pages={4632},
file={ISMRM2018_4632.pdf:ISMRM2018_4632.pdf:PDF},
title={Spin Echo measurement of oxygen {BOLD} reactivity - A simple method for mapping functional capillary blood volume?},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4632.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Michael Germuska and Richard Wise},
abstract={A simple non-invasive method is presented for the mapping of functional cerebral capillary blood volume. Functional capillary blood volume is a potentially powerful biomarker that is highly correlated with the average rate of glucose metabolism in the tissue. In-vivo maps of capillary blood volume are shown to be highly correlated with resting CBF in healthy volunteers and can be easily acquired within a few minutes with standard MR imaging sequences.}
}
@inproceedings{ISMRM2018_4633,
annote={ISMRM2018_4633},
pages={4633},
file={ISMRM2018_4633.pdf:ISMRM2018_4633.pdf:PDF},
title={Differences in {BOLD} temporal behavior in the cortical and subcortical structures of the visual and somatosensory systems},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4633.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Daniil P. Aksenov and Michael J. Miller and Limin Li and Alice M. Wyrwicz},
abstract={The temporal behavior of the BOLD response can vary considerably between nodes within sensory circuits as well as across different modalities. Understanding the nature of these variations could provide more information about the factors that shape the hemodynamic response. In this work fMRI data were acquired from both thalamic and cortical regions of the visual and somatosensory systems during prolonged sensory stimulation. Our findings show that while the thalamic BOLD responses for both circuits were quite similar, the cortical responses showed different adaptive behavior, which may reflect underlying regional differences in the contributions of local excitatory/inhibitory processes.}
}
@inproceedings{ISMRM2018_4634,
annote={ISMRM2018_4634},
pages={4634},
file={ISMRM2018_4634.pdf:ISMRM2018_4634.pdf:PDF},
title={Brain or cardiovascular oscillation: ultra-slow oscillations under 0.01 Hz detected by resting-state f{MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4634.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Patricia Pais Roldán and Brian Edlow and Johannes Stelzer and Yuanyuan Jiang and Xin Yu},
abstract={A high amplitude slow wave component of frequency 0.005 to 0.012 Hz was observed in multiple resting state fMRI scans of the rat brain under different anesthetics. These ultra-slow waves were localized predominantly in the hypothalamus. We hypothesize that these ultra-slow oscillations might have a neurological origin and may contribute to the analysis of resting state connectivity, which is currently limited to frequencies above 0.01 Hz . Future studies should investigate the origin of these oscillations with an independent measure (e.g. calcium imaging) and the implications of their incorporation into the analysis of rs-fMRI.}
}
@inproceedings{ISMRM2018_4635,
annote={ISMRM2018_4635},
pages={4635},
file={ISMRM2018_4635.pdf:ISMRM2018_4635.pdf:PDF},
title={The interaction between neural and autonomic correlates of stress: a pilot study measuring simultaneous heart rate variability and {BOLD} f{MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4635.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ariane T Orosz and Andrea Federspiel},
abstract={Stress has been associated with autonomic arousal as well as functional alterations in frontal and limbic regions which are important in the regulation of autonomic activity. Latter can be indexed by heart rate variability (HRV). In the present pilot study simultaneous BOLD fMRI and HRV were measured during the performance of a stress test. In three healthy subjects stress, relaxation and paced breathing were associated with frontal and limbic activation. More subjects need to be measured in order to strengthen the results and to integrate them as neural markers in an integrative and multilevel model of stress.}
}
@inproceedings{ISMRM2018_4636,
annote={ISMRM2018_4636},
pages={4636},
file={ISMRM2018_4636.pdf:ISMRM2018_4636.pdf:PDF},
title={Hemodynamic modeling of laminar resolution f{MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4636.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Kamil Uludag and Martin Havlicek},
abstract={Neuronal laminar information reflected in high-resolution fMRI is reduced due to ascending veins, carrying hemodynamic changes from various cortical depths to surface draining veins. Here, we propose an invertible generative hemodynamic model, which takes the effect of ascending veins to the laminar-specific fMRI signal explicitly into account. We illustrate the versatility of this novel model to characterize common experimental observations in laminar fMRI: we show that the spatial increase of laminar fMRI towards CSF is due to baseline blood volume. In contrast, a peak in the middle layer is due to higher neuronal activity rather than higher baseline blood volume.}
}
@inproceedings{ISMRM2018_4637,
annote={ISMRM2018_4637},
pages={4637},
file={ISMRM2018_4637.pdf:ISMRM2018_4637.pdf:PDF},
title={Optimization of breath hold cerebrovascular reactivity mapping ({BH} {CVR}) at ultra-high field through temporal correction of the hemodynamic response function},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4637.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Shruti Agarwal and Jun Hua and Haris I. Sair and Sachin K. Gujar and Hanzhang Lu and Jay J. Pillai},
abstract={Cerebrovascular reactivity (CVR) provides clinical insight into vascular health and is useful for identifying cortical regions affected by neurovascular uncoupling (NVU). BOLD imaging using breath-hold (BH) tasks can be effectively used for CVR mapping. At 7T, spatial specificity can be improved relative to standard 3T imaging, but optimization of CVR maps is often problematic. We propose temporal correction of the theoretical hemodynamic response function (HRF) to account for subject-wise temporal adjustment of the average respiration-induced hemodynamic response to a BH task to optimize 7T BH CVR maps in cases of poor patient task compliance.}
}
@inproceedings{ISMRM2018_4638,
annote={ISMRM2018_4638},
pages={4638},
file={ISMRM2018_4638.pdf:ISMRM2018_4638.pdf:PDF},
title={Optimization of motor f{MRI} activation in the setting of brain tumors via temporal resampling applied to the canonical {HRF}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4638.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Shruti Agarwal and Jun Hua and Haris I. Sair and Sachin K. Gujar and Scott Faro and Hanzhang Lu and Jay J. Pillai},
abstract={BOLD fMRI, which is an indirect measure of neuronal activity, involves several seconds offset in both initiation and cessation of the microvascular response with respect to actual timing of neural activity. In this study, we propose resampling of the canonical hemodynamic response function (HRF) to account for subject-wise temporal variability in BOLD responses in task paradigms. We demonstrate that temporal resampling of the canonical HRF may allow recapturing of lost signals in motor task activation maps (task fMRI). Further, it can also mitigate the effects of neurovascular uncoupling (NVU) in the sensorimotor network in patients with perirolandic gliomas.}
}
@inproceedings{ISMRM2018_4639,
annote={ISMRM2018_4639},
pages={4639},
file={ISMRM2018_4639.pdf:ISMRM2018_4639.pdf:PDF},
title={Demonstration of brain tumor-induced neurovascular uncoupling within the language network at ultra-high field},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4639.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Shruti Agarwal and Jun Hua and Haris I. Sair and Hanzhang Lu and Jay J. Pillai},
abstract={False-negative activations caused by neurovascular uncoupling (NVU) can lead to erroneous interpretation of clinical BOLD fMRI examinations. At 7T, spatial specificity can be improved relative to clinical 3T imaging. In this study, we demonstrate that NVU within the language network may affect the resting-state (rsfMRI) frequency domain metric ALFF (amplitude of low-frequency fluctuation) and breathhold cerebrovascular reactivity (BH CVR) maps as evident in the criterion standard task fMRI at ultra-high field despite known substantial BOLD signal-to-noise ratio advantages provided by higher field strength, which may not fully mitigate the effects of such NVU.}
}
@inproceedings{ISMRM2018_4640,
annote={ISMRM2018_4640},
pages={4640},
file={ISMRM2018_4640.pdf:ISMRM2018_4640.pdf:PDF},
title={Resting state default-mode network functional connectivity correlates with Glutamate +Glutamine/Creatine ratio of the medial prefrontal cortex in methamphetamine males : An f{MRI}-{MRS} study},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4640.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Qiuxia Wu and Chang Qi and Yanhui Liao and Jingsong Tang and We Hao and Tieqiao Liu},
abstract={This study investigates the functional connectivity (FC) of medial prefrontal cortex (mPFC) within default mode network (DMN) and the ratio of Glutamate+Glutamine/Creatine (Glx/Cr) in male methamphetamine-dependent subjects (MADs). We combined functional magnetic resonance imaging and magnetic resonance spectroscopy to investigate the altered FC and its relation with ratio of Glx/Cr in 54 male MADs and 52 healthy male controls. We found increased FC of mPFC with left posterior cingulate cortex and the ratio of Glx/Cr and their negative relation in male MADs. Our results may help with investigation of MADs pathophysiology.}
}
@inproceedings{ISMRM2018_4641,
annote={ISMRM2018_4641},
pages={4641},
file={ISMRM2018_4641.pdf:ISMRM2018_4641.pdf:PDF},
title={Brain states govern resting state functional connectivity dynamics},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4641.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Felipe Aedo Jury and Lara Hamzehpour and Albrecht Stroh},
abstract={A key aspect governing spatio-temporal activity patterns in fMRI is the brain state, particularly in animals being imaged mostly during sedation or anesthesia. Two main brain states have been recently identified in rodents[1], a persistent state similar to awake conditions and a slow wave state characterized by spontaneous slow oscillation-associated slow wave activity. We analyzed the brain functional connectivity using spontaneous BOLD recordings in rats during these different states. We found that both states lead to differential functional connectivity patterns that can be clearly dissociated. These results are crucial for interpreting rodent studies in the framework of translational resting state research.}
}
@inproceedings{ISMRM2018_4642,
annote={ISMRM2018_4642},
pages={4642},
file={ISMRM2018_4642.pdf:ISMRM2018_4642.pdf:PDF},
title={Simultaneous acquisition of {CBV}, {CBF} and {BOLD} signals induced by visual stimulations of 1, 4 and 8 Hz under normoxia and hypoxia conditions},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4642.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yaoyu Zhang and Yayan Yin and Bing Wu and Yang Fan and Jia-Ηοng Gao},
abstract={A simultaneous acquisition of VASO, ASL and BOLD signals was employed to measure relative functional changes induced by a block-designed, black-and-white checkerboard visual task containing three stimulus frequencies and two oxygen-level conditions. We report that 1) δCBV, δCBF and δBOLD increase along with visual stimulus frequencies for both oxygen-level conditions; 2) δBOLD, but not δCBV or δCBF, acquired under hypoxia condition is significantly lower than that acquired under normoxia condition for all the three stimulus frequencies. According to Fick’s principle, our results predict increases of oxygen consumption rate among various stimulus frequencies during hypoxia.}
}
@inproceedings{ISMRM2018_4643,
annote={ISMRM2018_4643},
pages={4643},
file={ISMRM2018_4643.pdf:ISMRM2018_4643.pdf:PDF},
title={Probing the Signal Physiology of Resting-State f{MRI} at High Frequencies using Hypocapnia},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4643.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Abraham Dominguez Hernandez and Arpad Zolyomi and Arvind Caprihan and Kishore Vakamudi and Stephen R Dager and Stefan Posse},
abstract={We investigate the dependence of high frequency signal changes on decreases in global blood flow using hyperventilation induced hypocapnia, which substantially alter the amplitude and time course of the hemodynamic response function (HRF) with only minor changes in neural activation levels. We also investigate the sensitivity of multi-band-EPI and a prototype ultra-high-speed multi-band-EVI (MB-EVI) sequence for detecting high frequency correlations. In the first subject, an increase in high frequency correlations during hypocapnia was detected in MB-EPI and MB-EVI. These studies suggest that high frequency signals changes may be mediated by vascular physiology, but movement related artifacts cannot be excluded.}
}
@inproceedings{ISMRM2018_4644,
annote={ISMRM2018_4644},
pages={4644},
file={ISMRM2018_4644.pdf:ISMRM2018_4644.pdf:PDF},
title={3D Pseudocontinuous Arterial Spin-Labeling Perfusion Imaging Detected Crossed Cerebellar Daschisis at Acute, Subacute and Chronic Intracerebral Hemorrhage},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4644.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Liang Yin and Ying Zhu and Jiangxi Xiao},
abstract={Crossed cerebellar diaschisis (CCD) is the phenomenon of a decreased cerebellar perfusion and glucose metabolism in the cerebellar hemisphere contralateral to a supratentorial cerebral lesion. Although mostly seen in cerebral infarct, CCD has been reported in other clinical conditions such as intracerebral hemorrhage. Recently findings suggested that CCD is not just a neuroradiological phenomenon, arterial spin-labeling (ASL) is a novel noninvasive MRI method that uses arterial water as an endogenous tracer for perfusion imaging. The purpose of this study were to evaluate the value of 3D pCASL to detect CCD in different stage of ICH and to identify the relevant imaging or clinical factors of CCD development.}
}
@inproceedings{ISMRM2018_4645,
annote={ISMRM2018_4645},
pages={4645},
file={ISMRM2018_4645.pdf:ISMRM2018_4645.pdf:PDF},
title={Caffeine enhances {BOLD} response to electrical whisker pad stimulation in rats},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4645.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Shao-Chieh Chiu and Chiun-Wei Huang and Shin-Lei Peng},
abstract={The effects of caffeine on BOLD responses are still controversial. The potential explanation to this discrepancy may be associated with different dietary caffeine consumption among subjects. Here, we test the effect of caffeine on BOLD responses by using the caffeine-naïve animals. By reducing the baseline cerebral blood flow and therefore increasing the baseline deoxygenation concentration, caffeine significantly enhanced the magnitude of BOLD responses to the electrical whisker pad stimulation. These findings may suggest that caffeine-naïve animals could be a potential model to shed more light on effects of caffeine on BOLD fMRI measurements.}
}
@inproceedings{ISMRM2018_4646,
annote={ISMRM2018_4646},
pages={4646},
file={ISMRM2018_4646.pdf:ISMRM2018_4646.pdf:PDF},
title={Enhancement of the Negative {BOLD} Response with {DANTE}-{EPI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4646.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Linqing Li and Yuhui Chai and Andy Derbyshire and Karla Miller and Peter Jezzard and Peter Bandettini},
abstract={We derived and verified an equation for the theoretical description of longitudinal magnetization for pass- and transition-band bSSFP at steady state. In addition, we show evidence that a DANTE (b-SSFP) preparation module may be employed with an EPI readout to increase negative BOLD response by 12.8\% in average (p<0.03) compared to conventional EPI (GE-EPI).}
}
@inproceedings{ISMRM2018_4647,
annote={ISMRM2018_4647},
pages={4647},
file={ISMRM2018_4647.pdf:ISMRM2018_4647.pdf:PDF},
title={The vascular fingerprint of non-balanced {BOLD} {SSFP} coherence pathways: gradient echoes show spin echo behavior},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4647.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Klaus Scheffler and Mario Gilberto Báez-Yánez and Gabriele Lohmann},
abstract={The S2-SSFP echo (the echo before the RF pulse in non-balanced SSFP sequences, or F
-0, PSIF, CE-FAST, T2-FFE) is a refocused echo and has thus been proposed for BOLD imaging to suppress larger vessels, similar to the classical spin echo. Here we demonstrate in Monte Carlo simulations that the primary S1-SSFP gradient echo shows nearly identical properties as the S2-SSFP echo. Both echoes of this non-balanced SSFP sequence can be used for BOLD imaging exhibiting a pure spin echo behavior, i.e suppression of larger vessels.}
}
@inproceedings{ISMRM2018_4648,
annote={ISMRM2018_4648},
pages={4648},
file={ISMRM2018_4648.pdf:ISMRM2018_4648.pdf:PDF},
title={Infrequent auditory stimuli elicit {BOLD} signals of shorter duration},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4648.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jo-Fu Lotus Lin and Yi-Ting Lin and Juan Silva-Pereyra and Fa-Hsuan Lin},
abstract={To characterize the hemodynamic responses of mismatch negativity, we measured BOLD signals elicited by frequent and infrequent sequences of sounds using fast fMRI acquisitions with 0.1 s precision. The average temporal width of the hemodynamic responses was 4.2 s in the superior temporal areas. The width of hemodynamic responses was significantly wider in the standard (4.9 s +/- 1.1 s) than the deviant trials (3.6 s +/- 1.7 s).}
}
@inproceedings{ISMRM2018_4649,
annote={ISMRM2018_4649},
pages={4649},
file={ISMRM2018_4649.pdf:ISMRM2018_4649.pdf:PDF},
title={Vascular Origins of “Anti-correlations” in Resting-State f{MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4649.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Mahdi Khajehim and J. Jean Chen},
abstract={Several explanations for the existence of anti-correlations in rsfMRI have been suggested so far, ranging from true neural activity to a side effect of preprocessing. In this abstract, we investigate the possible vascular origins of anti-correlation by presenting a biophysical model that is inspired by past simulation studies. Our model suggests resting-state BOLD anti-correlations across voxels may arise simply from the physiological and magnetic properties of arterial and venous blood and may not be solely due to anti-correlated neural activity.}
}
@inproceedings{ISMRM2018_4650,
annote={ISMRM2018_4650},
pages={4650},
file={ISMRM2018_4650.pdf:ISMRM2018_4650.pdf:PDF},
title={Vascular Origins of the Negative {BOLD} f{MRI} Response},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4650.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Mahdi Khajehim and J. Jean Chen},
abstract={While the origin of negative BOLD response in fMRI has been debated, we present an explanatory biophysical model that accounts for imaging and physiological parameters, including vascular-orientation, CBV change, TR, TE, inflow and even different oxygenation levels in arterial and venous compartments. This model shows that it is possible for negative BOLD to arise from both arterial and venous sources even in the presence of neural-activity increase. This abstract suggests part of the negative BOLD response originates simply from the vascular origin of the signal.}
}
@inproceedings{ISMRM2018_4651,
annote={ISMRM2018_4651},
pages={4651},
file={ISMRM2018_4651.pdf:ISMRM2018_4651.pdf:PDF},
title={Activating glucose transporter 2 positive neurons stimulates cerebral blood flow},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4651.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Hongxia Lei and Gwenaël Labouèbe and Bernard Thorens},
abstract={Glucose transporter 2 (Glut2)-positive cells are sparsely distributed in brain and play an important role in the stimulation of glucagon secretion in response to hypoglycemia. The effect on CBF of optogenetic activation of hypoglycemia responsive Glut2-positive neurons of the paraventricular thalamic area was measured in mice expressing channelrhodopsin2 under the control of the Glut2 promoter. Optogenetic activation of Glut2-positive neurons in the paraventricular thalamic nucleus induced a local CBF change similar in magnitude to the effect of hypoglycemia. Thus, our data indicate that brain Glut2-positive neurons are key regulators of hypoglycemia-induced activation of CBF.
}
}
@inproceedings{ISMRM2018_4652,
annote={ISMRM2018_4652},
pages={4652},
file={ISMRM2018_4652.pdf:ISMRM2018_4652.pdf:PDF},
title={Optogenetically-initiated low frequency dorsal hippocampal activity enhances resting-state f{MRI} connectivity and visual memory retrieval performance},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4652.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Russell W. Chan and Eddie C. Wong and Alex T. L. Leong and Xunda Wang and Celia M. Dong and Karim E. Hallaoui and Lee W. Lim and Ed X. Wu},
abstract={Our recent study demonstrated that low frequency optogenetically-initiated hippocampal activities enhances brain-wide resting-state fMRI connectivity. However, the behavioral consequence of such connectivity enhancement remains unknown. Since hippocampus is known to play a prominent role in memory, we assessed the effects of such connectivity enhancement on short-term and long-term memory. Our experimental results demonstrated that, while low frequency dorsal hippocampus stimulation enhanced interhemispheric fMRI connectivity (in hippocampus, V1, A1 and S1), it also improved the long-term visual memory by enhancing memory retrieval (in contrast to memory encoding) performance.}
}
@inproceedings{ISMRM2018_4653,
annote={ISMRM2018_4653},
pages={4653},
file={ISMRM2018_4653.pdf:ISMRM2018_4653.pdf:PDF},
title={Left and right temporal lobe epilepsies with mesial temporal sclerosis reveal distinct alterations in the intrinsic effective connectivity within the Papez circuit},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4653.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yao-Chia Shih and Fa-Hsuan Lin and Horng-Huei Liou and Wen-Yih Isaac Tseng},
abstract={The present resting-state fMRI study performed structural equation modeling to evaluate intrinsic effective connectivity (iEC) within the Papez circuit in patients with unilateral temporal lobe epilepsy with mesial temporal sclerosis (TLE-MTS). Left TLE-MTS is characterized by decreased iEC on the left frontotemporal path, which might be associated with deficits in executive functions and working memory. Right TLE-MTS is characterized by decreased iEC on the paths in the right posterior limbic regions, which might be associated with deficits in autobiographical memory processing. Our findings might facilitate identifying potential epileptic network pathways and developing novel targeted therapies for unilateral TLE-MTS.}
}
@inproceedings{ISMRM2018_4654,
annote={ISMRM2018_4654},
pages={4654},
file={ISMRM2018_4654.pdf:ISMRM2018_4654.pdf:PDF},
title={Tract-specific footprint of functional interhemispheric connectivity in the brain},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4654.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jeroen Mollink and Saad Jbabdi and Michiel Kleinnijenhuis and Fidel Alfaro-Almagro and Anne-Marie van Cappellen van Walsum and Stephen M Smith and Karla L Miller},
abstract={Linking the anatomy of neuronal connections to brain function is fundamental to our understanding of how brain architecture underpins human cognition. In this work, we hypothesized that the microstructural features of a white matter pathway relate to functional connectivity between the brain regions it connects. In a large cohort of subjects from UK Biobank, we demonstrate that the functional connectivity of homotopic brain regions from the two hemispheres can be predicted from the microstructure of the tract that connects them.}
}
@inproceedings{ISMRM2018_4655,
annote={ISMRM2018_4655},
pages={4655},
file={ISMRM2018_4655.pdf:ISMRM2018_4655.pdf:PDF},
title={Serotonin transporter occupancy predicts default-mode network connectivity: a {SPECT} and rsf{MRI} study},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4655.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Anouk Schrantee and Paul J Lucassen and Jan Booij and Liesbeth Reneman},
abstract={The serotonergic neurotransmitter system is thought to play a substantial role in modulating the default mode network (DMN). For example, antidepressants (SSRIs) have consistently shown to decrease DMN connectivity. However, it is unclear whether SSRIs also dose-dependently affect DMN connectivity. Therefore, we investigated the association between SERT occupancy by SSRIs (SPECT) and DMN functional connectivity (rs-fMRI). We confirm a dose-dependent effect of SSRIs on connectivity with the DMN; higher SERT occupancy by the SSRI in the thalamus was significantly associated with decreased DMN connectivity. This suggests that DMN connectivity might be interesting biomarker, e.g. for treatment monitoring.}
}
@inproceedings{ISMRM2018_4656,
annote={ISMRM2018_4656},
pages={4656},
file={ISMRM2018_4656.pdf:ISMRM2018_4656.pdf:PDF},
title={Frequency preference and tuning width dependent intrinsic functional connectivity within and across cortical depths in the human auditory cortex},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4656.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Pu-Yeh Wu and Ying-Hua Chu and Jo-Fu Lotus Lin and Shang-Yueh Tsai and Wen-Jui Kuo and Fa-Hsuan Lin},
abstract={This study revealed the frequency preference as well as tuning width dependent intrinsic functional connectivity (iFC) within and across cortical depths in the human auditory cortex. We demonstrated that both the within-depth and cross-depth feature dependent iFC have a higher selectivity in the core than noncore region as we moved from superficial to deep cortical depths. We also found that the selectivity of cross-depth feature dependent iFC decreases when two cortical depths were farther away from each other. Taken together, our findings provide the direct evidence of a cortical depth specific feature dependent iFC in the human auditory cortex.}
}
@inproceedings{ISMRM2018_4657,
annote={ISMRM2018_4657},
pages={4657},
file={ISMRM2018_4657.pdf:ISMRM2018_4657.pdf:PDF},
title={Longitudinal Study Functional Reorganization within Resting-state Brain Networks in Subcortical Infarction Stroke Patients},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4657.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Caihong Wang and Peifang Miao and Yafei Guo and Dandan Zheng and Jingliang Cheng},
abstract={In order to identify dynamic evolution model of functional reorganization in stroke patients during recovery process based on the large-scale brain network, eleven meaningful RSNs derived from resting-state data across four consecutive time points within six months in subcortical infarction stroke patients and healthy controls groups were identified using independent component analysis. The results revealed that stroke patients exhibited significantly dynamic functional connectivity changes in the right superior parietal lobule of the dorsal attention network and the cuneus of medial visual networks. Note that functional connectivity to some meaningful brain networks demonstrated consistent alterations over time. The findings may reflect the adaptive reorganization of the functional network in stroke patients.}
}
@inproceedings{ISMRM2018_4658,
annote={ISMRM2018_4658},
pages={4658},
file={ISMRM2018_4658.pdf:ISMRM2018_4658.pdf:PDF},
title={Comparison of Spatial Profiles of Activation and Resting State f{MRI} Signals Across Cortical Depth},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4658.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Arabinda Mishra and Feng Wang and John C Gore and Li Min Chen},
abstract={FMRI at high spatial resolution is capable of resolving signals from different cortical layers providing the ability to examine local inter-layer information processing. In this study, we quantified the spatial profiles of BOLD fMRI activations and the point spread functions (PSF) of resting state correlations within layers. We found significantly broader extent of stimulus-evoked activity and resting state correlation profiles in the top layer than those in middle and lower layers. These differences may reflect differences in vasculature or neural activity between the layers.}
}
@inproceedings{ISMRM2018_4659,
annote={ISMRM2018_4659},
pages={4659},
file={ISMRM2018_4659.pdf:ISMRM2018_4659.pdf:PDF},
title={Assessing the functional connectivity of hippocampal subfields in healthy controls and {TLE}: a resting state f{MRI} study at 7T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4659.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Lisanne PW Canjels and Walter Backes and Tamar M van Veenendaal and Rob PW Rouhl and Marielle CG Vlooswijk and Albert P Aldenkamp and Jacobus FA Jansen},
abstract={It has been suggested that hippocampal subfields show functional specialization. Resting-state functional MRI studies have improved our understanding of brain function. Using rs-fMRI, we examined the possibility of segmenting the hippocampal subfields at 7T and assessed the functional correlations between the hippocampal subfields with other cortical regions. This method was tested in both healthy controls and temporal lobe epilepsy patients. Only small differences in functional connectivity between healthy controls and epilepsy patients were found. This study demonstrated the potential of assessing the resting-state functional connectivity of the hippocampal subfields with other regions of interest in the cortex.}
}
@inproceedings{ISMRM2018_4660,
annote={ISMRM2018_4660},
pages={4660},
file={ISMRM2018_4660.pdf:ISMRM2018_4660.pdf:PDF},
title={Resting State fc{MRI} Reveals Distinc Connectivity Patterns for Core-Belt-Parabelt Subfields of Human Auditory Cortex},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4660.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Michael Amann and Julia Reinhardt and Jan Benner and Elke Hofmann and Peter Schneider and Christoph Stippich and Maria Blatow},
abstract={Converging evidence supports the hypothesis that human auditory cortex (AC) follows the core-belt-parabelt organization found in non-human primates. In the study presented here, we assessed the functional connectivity of the core (medial Heschl’s gyrus, mHG), belt (posterior-lateral HG, plHG) and parabelt subfields (anterior-lateral HG, alHG and planum temporale, PT) by applying resting state functional connectivity MRI (fcMRI) on a cohort of 84 musicians. Assessing inter-hemispheric connectivity, we found significant differences between right and left plHG as well as in right and left PT. The contrast between the different subfields revealed highly differentiated neuronal networks, especially between mHG and plHG.}
}
@inproceedings{ISMRM2018_4661,
annote={ISMRM2018_4661},
pages={4661},
file={ISMRM2018_4661.pdf:ISMRM2018_4661.pdf:PDF},
title={Resting state Df{MRI} revealed alterations of brain activity and network in obsessive–compulsive disorder mouse model},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4661.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yoshifumi Abe and Yuki Sakai and Hiroaki Hamada and Norio Takata and Yuichi Hiraoka and Tomomi Aida and Kohichi Tanaka and Kenji Doya and Kenji Tanaka},
abstract={Diffusion fMRI (DfMRI) is a powerful functional imaging method to investigate neural activity and network without BOLD confounding hemodynamic effects. In this study, we applied DfMRI to evaluate brain activity and network of neuropsychiatric disease model, obsessive–compulsive disorder (OCD). Our DfMRI study revealed that the cortex was excited and the hippocampus was inhibited. Functional connectivity analysis of DfMRI detected alterations of cortico-striatal-thalamic networks, in line with the previous study with OCD patients. Additionally, we found that interesting network alterations of the hippocampal networks in this OCD model mice.}
}
@inproceedings{ISMRM2018_4662,
annote={ISMRM2018_4662},
pages={4662},
file={ISMRM2018_4662.pdf:ISMRM2018_4662.pdf:PDF},
title={Alterations in resting-state functional connectivity in patients with Crohn’s disease in remission},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4662.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jiancheng Hou and Rosaleena Mohanty and VEENA A NAIR and Poonam Beniwal-Patel and Vivek Prabhakaran and Sumona Saha},
abstract={Crohn’s disease (CD) is a chronic inflammatory disorder that commonly affects the small intestine and is a phenotype of inflammatory bowel disease (IBD). Several studies have reported changes in cortical thickness and neurologic deficits in patients with IBD. Here we report alterations in resting state functional MRI connectivity in patients in CD in remission compared to healthy controls, specifically in the executive control and default mode networks. Alterations in resting state functional connectivity in patients with CD may explain some of the mechanisms underlying the development and progression of CD and associated deficits in cognitive and affective functioning.}
}
@inproceedings{ISMRM2018_4663,
annote={ISMRM2018_4663},
pages={4663},
file={ISMRM2018_4663.pdf:ISMRM2018_4663.pdf:PDF},
title={Effect of abstinent duration on brain function in heroin addicts: a resting-state f{MRI} study},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4663.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Xin Li and Qiang Li and Jiajie Chen and Wei Li and Yongbin Li and Jierong Liu and Xuan Wei and Xiaohuai Li and Wei Wang},
abstract={Heroin addiction is increasingly severe in China. Protracted abstinence is commonly used in China. However the effect of protracted abstinence treatment on brain function of heroin dependent patients remains unclear. Previous studies have demonstrated that resting state functional connectivity and amplitude of low frequency fluctuation (ALFF)is useful for studying function of brain.Using the above methods, we found that that prolonged abstinent duration is conducive to function restoring of brain network in heroin-dependent patients, which may be useful to reduce the risk of relapse of heroin addicts.}
}
@inproceedings{ISMRM2018_4664,
annote={ISMRM2018_4664},
pages={4664},
file={ISMRM2018_4664.pdf:ISMRM2018_4664.pdf:PDF},
title={Modulation of Perfusion and Functional Connectivity by Intermittent Theta Burst Stimulation},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4664.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Marc Lindley and Mark Sundman and Chidi Ugonna and Nan-kuei Chen and Ying-hui Chou},
abstract={Transcranial magnetic stimulation produces a noninvasive stimulation that excites or inhibits regions of the brain. Theta burst stimulation(TBS), has been considered the most efficient protocol. The impact of TBS on brain perfusion and intrinsic functional connectivity networks of human brains has not been systematically evaluated. Perfusion values were measured with pCASL and resting state fMRI was performed to compare connectivity networks using seed based analysis and matrix based analysis. Perfusion was measured as increased after iTBS. Analysis of seed based data generated from the left dorsolateral prefrontal cortex showed connectivity network changes before and after TBS.}
}
@inproceedings{ISMRM2018_4665,
annote={ISMRM2018_4665},
pages={4665},
file={ISMRM2018_4665.pdf:ISMRM2018_4665.pdf:PDF},
title={Alteration of resting state functional connectivity following cocaine self-administration},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4665.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Sung-Ho Lee and Heather K Decot and Fei Fei Wang and Regina M. Carelli and Yen-Yu Ian Shih and Garret D Stuber},
abstract={We investigate the alteration of resting-state functional connectivity across the brain following self-administration of cocaine in the rat. The result of group-independent component analysis (ICA) and dual regression reveals that cocaine self-administration orchestrates dynamic shifts in co-activity and functional connectivity across resting-state neuronal networks and nodes, several of which that do not directly receive dopamine input.}
}
@inproceedings{ISMRM2018_4666,
annote={ISMRM2018_4666},
pages={4666},
file={ISMRM2018_4666.pdf:ISMRM2018_4666.pdf:PDF},
title={Disease Definition for Schizophrenia by Functional Connectivity using Radiomics Strategy},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4666.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Long-Biao Cui and Lin Liu and Yi-Bin Xi and Wei Qin and Hong Yin},
abstract={Specific biomarker reflecting its neurobiological substrates is required for diagnosis and treatment selection of schizophrenia (SZ). We aimed to develop and validate a method of disease definition for SZ by resting-state functional connectivity using radiomics strategy in two data sets. The accuracy was 87.09\% for diagnosing SZ patients by applying functional connectivity features, with a validation in the independent replication data set (accuracy = 82.61\%). Our findings demonstrate a valid radiomics approach by functional connectivity to diagnose SZ, which is helpful to facilitate objective SZ individualized diagnosis using quantitative and specific functional connectivity biomarker in different sites.}
}
@inproceedings{ISMRM2018_4667,
annote={ISMRM2018_4667},
pages={4667},
file={ISMRM2018_4667.pdf:ISMRM2018_4667.pdf:PDF},
title={Functional connectivity {MRI} in head-fixed awake mice differentiates acute and chronic neuroinflammation},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4667.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Esteban Adrian Oyarzabal and Carolyn Liu and Tzu-Wen Wang and Yen-Yu Ian Shih},
abstract={Differentiating between acute and chronic neuroinflammation could improve clinical diagnoses of Alzheimer's disease, multiple sclerosis and Parkinson's disease as well as disorders with no established clinical diagnostic methods such as Chronic Traumatic Encephalopathy and Chronic Fatigue Syndrom. This study implements mouse models of acute and chronic neuroinflammation to examine how neuroinflammation alter fcMRI in awake mice.}
}
@inproceedings{ISMRM2018_4668,
annote={ISMRM2018_4668},
pages={4668},
file={ISMRM2018_4668.pdf:ISMRM2018_4668.pdf:PDF},
title={Functional Connectivity changes during Real-time f{MRI} based Neuro-rehabilitation of post-stroke Aphasic Patients.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4668.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Sujesh Sreedharan and Arun K. M. and Sylaja P. N. and Ranaganatha Sitaram and Kesavadas C.},
abstract={Recovery from stroke to lead an improved life is one of the most sought after rehabilitation programs around the globe. Various factors are involved in the process of restoration of an impaired function. The study examined the functional network disruption due to stroke and the network changes happening during the real-time fMRI based neurofeedback training for aphasic stroke survivors to retrain the language areas. The results show that though the contralateral hemisphere for test group has strong connections when compared with controls and with training the ipsilateral connections are strengthened and are recovering through alternate connections.}
}
@inproceedings{ISMRM2018_4669,
annote={ISMRM2018_4669},
pages={4669},
file={ISMRM2018_4669.pdf:ISMRM2018_4669.pdf:PDF},
title={Increased functional connectivity in the {SOD}1(G93A) animal model of Amyotrophic Lateral Sclerosis: a rs-f{MRI} study at 4.7T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4669.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Pietro Bontempi and Rachele Podda and Alice Busato and Roberta Bonafede and Ilaria Scambi and Raffaella Mariotti and Pasquina Marzola},
abstract={To date fMRI studies on Amyotrophic Lateral Sclerosis (ALS) patients are still inconsistent. Here, we performed a rs-fMRI study on a pre-clinical model of ALS with the aim to identify biomarkers at functional level, defining an experimental platform useful for the evaluation of disease progression and therapies development. rs-fMRI was performed in SOD1(G93A) and WT mice using a 4.7T tomograph and an EPI sequence. Our results showed increased functional connectivity in SOD1(G93A) mice at the end-stage of disease. In this work, we defined a functional testbed for ALS animal model and demonstrated the feasibility of rs-fMRI in mice at 4.7T.}
}
@inproceedings{ISMRM2018_4670,
annote={ISMRM2018_4670},
pages={4670},
file={ISMRM2018_4670.pdf:ISMRM2018_4670.pdf:PDF},
title={{BRAIN} {FUNCTIONAL} {CHANGES} {CORRELATE} {WITH} {COGNITIVE} {DYSFUNCTION} {IN} {FRIEDREICH}'S {ATAXIA}: {AN} {RS}-f{MRI} {STUDY}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4670.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Sirio Cocozza and Teresa Costabile and Enrico Tedeschi and Filomena Abate and Camilla Russo and Agnese Liguori and Walter Del Vecchio and Francesca Paciello and Mario Quarantelli and Alessandro Filla and Francesco Saccà and Arturo Brunetti},
abstract={We performed a seed-based Resting-State fMRI analysis in Friedreich’s Ataxia (FRDA) patients to assess possible brain functional connectivity (FC) changes in these patients, which are know to be charactherized by an impairment of neuropsychological functions. We found an increased FC in FRDA patients compared to controls in different brain regions, including the medial frontal gryrus, the angular gyri and cingulate gyrus, with a decreased cerebellar FC. Our findings of diffuse alterations of FC in FRDA patients compared to controls may shed new light on the pattern of supratentorial and infratentorial involvement and on dynamics of brain plasticity in this condition.}
}
@inproceedings{ISMRM2018_4671,
annote={ISMRM2018_4671},
pages={4671},
file={ISMRM2018_4671.pdf:ISMRM2018_4671.pdf:PDF},
title={{PRAGMATIC} {ABILITIES} {IN} {MULTIPLE} {SCLEROSIS} {PATIENTS}: {AN} {RS}-f{MRI} {STUDY}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4671.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Sirio Cocozza and Antonio Carotenuto and Mario Quarantelli and Giorgio Arcara and Vincenzo Brescia Morra and Enrico Tedeschi and Giuseppe Orefice and Valentina Bambini and Rosa Iodice and Arturo Brunetti},
abstract={Multiple Sclerosis (MS) patients could experience communicative deficits in “pragmatics”, which is the ability to integrate context-dependent aspects of meaning beyond structural components of language. We evaluated relationships between pragmatics and functional connectivity (FC) of the bilateral inferior parietal lobule (the so-called Geschwind’s areas -GA-), in MS patients via a seed-based Resting-State fMRI analysis. We found a direct correlation between pragmatic scores and FC of both right (p=0.003) and left (p=0.009) GAs with the paracingulate cortex. Our results suggest that language is not only a left hemisphere function and highlight a possible central role of paracingulate cortex in pragmatics.}
}
@inproceedings{ISMRM2018_4672,
annote={ISMRM2018_4672},
pages={4672},
file={ISMRM2018_4672.pdf:ISMRM2018_4672.pdf:PDF},
title={Functional brain abnormalities in major depressive disorder: evidence from a Chinese multi-site resting-state functional {MRI} study},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4672.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Mingrui Xia and Tianmei Si and Xiaoyi Sun and Qing Ma and Bangshan Liu and Li Wang and Jie Meng and Miao Chang and Xiaoqi Huang and Ziqi Chen and Yanqing Tang and Ke Xu and Qiyong Gong and Fei Wang and Jiang Qiu and Peng Xie and Lingjiang Li and Yong He},
abstract={MDD is characterized by disturbances in mood and cognitive functions; however, the pathophysiological mechanism of MDD is incompletely understood. Using the largest resting-state fMRI MDD dataset in China with 1,434 participants, we revealed significant lower functional coordination in the orbitofrontal and primary sensorimotor and visual cortices and higher coordination in the lateral/medial frontoparietal cortices in MDD. These abnormalities were not affected by medication status but were partially influenced by episode number and onset age in patients. These findings provide solid evidence for functional brain disturbances and crucial insights into neuroimaging-based methods for early diagnosis and therapeutic optimization in MDD.}
}
@inproceedings{ISMRM2018_4673,
annote={ISMRM2018_4673},
pages={4673},
file={ISMRM2018_4673.pdf:ISMRM2018_4673.pdf:PDF},
title={{COMT} Val158Met polymorphism modulated the relationship between functional connectivity in prefrontal cortex and working memory performance},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4673.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Sichu Wu and Zhao Qing and Jiaming Lu and Yi Sun and Ming Li and Weiping Li and Yingci Yan and Xue Liang and Junxia Wang and Bin Zhu and Xin Zhang and Bing Zhang},
abstract={Compared with participants with COMT rs4680-GG, the healthy Han Chinese participants with rs4680-A-allele showed higher degree centrality and functional connectivity in medial prefrontal cortex in resting-state BOLD. The rs4680-A-allele carriers also performed better in 3-back performance than rs4680-GG carriers and the accuracy of 3-back has significant correlation with functional connectivity value, which indicated that the COMT rs4680 mutation modulated the functional connectivity and working memory performance.}
}
@inproceedings{ISMRM2018_4674,
annote={ISMRM2018_4674},
pages={4674},
file={ISMRM2018_4674.pdf:ISMRM2018_4674.pdf:PDF},
title={Reorganization of Homotopic Functional Connectivity in two Profiles of High Potential Children: a resting-state f{MRI} and {DTI} Study},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4674.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ilaria Suprano and Chantal Delon-Martin and Gabriel Kocevar and Claudio Stamile and Sophie Achard and Pierre Fourneret and Olivier Revol and Fanny Nusbaum and Dominique Sappey-Marinier},
abstract={Several changes were previously found in functional and structural networks of High Potential (HP) children but interhemispheric communication was not investigated. In this study, we studied the homotopic connectivity between pairs of left and right hemispheres regions in three groups of children with standard IQ, homogeneous and heterogeneous high IQ. Functional and structural connectivity were investigated using resting-state fMRI and DTI tractography, respectively and graph theory for brain network analysis. Our findings showed a reorganization of functional homotopic connectivity involving precuneus, amygdala and frontal pole regions in HP children.}
}
@inproceedings{ISMRM2018_4675,
annote={ISMRM2018_4675},
pages={4675},
file={ISMRM2018_4675.pdf:ISMRM2018_4675.pdf:PDF},
title={Acute changes in blood glucose levels affect the resting state functional connectivity in mice},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4675.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Tomokazu Tsurugizawa and Boucif Djemai and Tangi Roussel and Luisa Ciobanu},
abstract={Dopaminergic network can be modified by the blood glucose levels. The medetomidine, which is commonly used anesthesia in functional MRI, increases the blood glucose levels. In the present study, we compared the functional connectivity in fasted or non-fasted mice under isoflurane or medetomidine anesthesia. The blood glucose levels in non-fasted mice under medetomidine anesthesia significantly increased but isoflurane did not. The correlation coefficients in the dopamine network were significantly higher in fasted mice compared with non-fasted mice under medetomidine, but not under isoflurane. These results indicate that medetomidine-induced blood glucose increase altered the functional connectivity in the dopaminergic network.
}
}
@inproceedings{ISMRM2018_4676,
annote={ISMRM2018_4676},
pages={4676},
file={ISMRM2018_4676.pdf:ISMRM2018_4676.pdf:PDF},
title={Small (< 4 cm) Renal Masses:Differentiation of clear cell Renal Cell Carcinoma from non-clear cell Renal Cell Carcinoma Using Whole Tumor {ADC} Histogram Analysis at r-Fov {DWI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4676.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Haojie Li},
abstract={The combination of r-FOV DWI and the whole-lesion histogram analysis method may help in the interpretation of DWI of small renal masses and determine the optimal ADC parameter for quantitative assessment. The 75th percentile ADC value was more reliable than other histogram parameter values in distinguishing clear cell from non-clear cell RCCs with high sensitivity and specificity, potentially improving the accuracy of pretreatment diagnosis and selection of clinical therapy.}
}
@inproceedings{ISMRM2018_4677,
annote={ISMRM2018_4677},
pages={4677},
file={ISMRM2018_4677.pdf:ISMRM2018_4677.pdf:PDF},
title={Utility of 3D histogram analysis of pharmacokinetics parameters using {DCE}-{MRI} for differentiating renal clear cell carcinomas from renal harmatomas},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4677.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yanping Miao and Yang Gao and Peng Cao and Lizhi Xie},
abstract={The aim of this study was to assess if the histogram analysis of DCE-MRIphamocokinetics parameters (Ktrans)can differentiate renal tumors: renal clear cell carcinomas (RCCs) and renal harmatoma with minimal fat. Based on an 3D entire-tumour measurement, the following histogram parameters of Ktrans were derived from histogram analysis, skewness, Energy, Entropy, Uniformity, quartile5, quartile50, Frequency size and kurtosis respectively. We concluded that frequency size was the most significant parameter for predicting renal clear cell carcinoma by analyzing these data,the other parameters had no diagnostic performance.}
}
@inproceedings{ISMRM2018_4678,
annote={ISMRM2018_4678},
pages={4678},
file={ISMRM2018_4678.pdf:ISMRM2018_4678.pdf:PDF},
title={The Diagnostic Accuracy of {MR} Imaging for Acute Pyelonephritis},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4678.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Amarpreet Bhowra and Iva Petkovska and Diego Martin and Bobby Kalb},
abstract={MRI may offer a valuable alternative imaging method to diagnosing acute pyelonephritis without exposing patients to ionizing radiation or iodinated CT contrast. Our retrospective study evaluates the accuracy of 4 characteristic MRI findings in diagnosing acute pyelonephritis: (1) T2 hyperintense perinephric edema, (2) loss of corticomedullary differentiation on T2 images, (3) striated nephrogram on contrast-enhanced images and (4) parenchymal restricted diffusion. Analysis of 108 MRI exams demonstrated that each of the 4 MRI findings was a significant predictor of pyelonephritis. Furthermore, assessing all 4 findings together provided a greater improvement in diagnostic accuracy when compared to any individual finding alone.}
}
@inproceedings{ISMRM2018_4679,
annote={ISMRM2018_4679},
pages={4679},
file={ISMRM2018_4679.pdf:ISMRM2018_4679.pdf:PDF},
title={Clinical utility of susceptibility-weighted {MR} sequence ({SWAN}) for the evaluation of uterine sarcomas},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4679.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Mayumi Takeuchi and Kenji Matsuzaki and Masafumi Harada},
abstract={Intra-tumoral hemorrhagic necrosis is one of the characteristic pathological finding of uterine sarcomas. High intensity hemorrhagic foci on T1WI may be suggestive finding, however, the prevalence is not high possibly because only methemoglobin could be detected. Signal voids on SWAN may reflect all phases of hemorrhage, especially both deoxyhemoglobin and hemosiderin and could be useful for the diagnosis. Surgically proven ten sarcomas and 22 benign leiomyomas were retrospectively evaluated. High intensity foci on T1WI were detected in four sarcomas (40\%) and in none of leiomyomas, whereas signal voids on SWAN were detected in all sarcomas and in one leiomyoma (5\%).}
}
@inproceedings{ISMRM2018_4680,
annote={ISMRM2018_4680},
pages={4680},
file={ISMRM2018_4680.pdf:ISMRM2018_4680.pdf:PDF},
title={Clinical feasibility of reduced field-of-view diffusion-weighted imaging for assessing the local extent of cervical cancer},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4680.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Mayumi Takeuchi and Kenji Matsuzaki and Masafumi Harada},
abstract={The diagnostic performance of reduced FOV DWI (rFOV-DWI) for assessing the local extent of surgically proven 24 cervical cancers was evaluated. The delineation of tumor margin on rFOV-DWI was assessed and invasion to the vagina and parametrium evaluated on rFOV-DWI was compared with the histologically confirmed tumor extent. rFOV-DWI delineated the tumor margins better than T2WI and 3D DCE-MRI with statistically significance. Parametrial invasion and vaginal invasion as documented by rFOV-DWI agreed with the histopathological findings in 100\% and 95\% of cases, respectively.}
}
@inproceedings{ISMRM2018_4681,
annote={ISMRM2018_4681},
pages={4681},
file={ISMRM2018_4681.pdf:ISMRM2018_4681.pdf:PDF},
title={Developing and validating a multivariable prediction model to improve the diagnostic accuracy in determination of cervical vs. endometrial origin of uterine adenocarcinomas: A prospective {MR} study combining diffusion-weighted imaging and spectroscopy},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4681.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Gigin Lin and Yu-Chun Lin and Shang-Yueh Tsai and Yu-Ting Huang and Chyong-Huey Lai},
abstract={We developed and validated an MDS score based on integrated morphological, volumetric DW MR imaging and spectroscopy which has incremental values and may be a useful clinical biomarker in distinguishing adenocarcinomas of cervical or endometrial origin.}
}
@inproceedings{ISMRM2018_4682,
annote={ISMRM2018_4682},
pages={4682},
file={ISMRM2018_4682.pdf:ISMRM2018_4682.pdf:PDF},
title={{MR} neurography of the female pelvis: mapping somatic and autonomic nerves and plexi},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4682.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Katja N De Paepe and David M Higgins and Iain Ball and Veronica A Morgan and Nandita DeSouza},
abstract={The visualization of somatic and autonomic female pelvic nerves using a modified NerveVIEW protocol was assessed in volunteers (n=5) and cervical cancer patients (n=7) by 2 independent observers. Image quality (as assessed by visualization of the tibial and fibular components of the sciatic nerve) was high in 75\% of cases. 83\% of pudendal, superior and inferior hypogastric nerves were well seen by observer1 and 72\% by observer2. The superior hypogastric plexus (SHP) was more difficult to identify routinely. Neurography of the female pelvis allowed for confident identification of autonomic and somatic nerve plexi and has potential for pre-surgical planning.}
}
@inproceedings{ISMRM2018_4683,
annote={ISMRM2018_4683},
pages={4683},
file={ISMRM2018_4683.pdf:ISMRM2018_4683.pdf:PDF},
title={Intravoxel incoherent motion diffusion imaging for grading endometrial cancer},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4683.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Qi Zhang and Xiaoduo Yu and Han Ouyang and Lizhi Xie},
abstract={Accurate grading of endometrial cancer (EC) is invaluable owing to its relationship with the aggressiveness, prognosis, recurrence as well as its impact on treatment stratification. The differentiation of tumor correlates with the tumor density, the nuclear-to-cytoplasm ratio and microcirculation, which can be quantitatively assessed by using ADC and IVIM parameters (such as D, D* and f). The ADC, D and f values showed good or fair inverse correlation with histological grade. Therefore, IVIM DWI is a valuable supplement to predict histological grade of EC preoperatively which could contribute to treatment planning and prognosis evaluation.}
}
@inproceedings{ISMRM2018_4684,
annote={ISMRM2018_4684},
pages={4684},
file={ISMRM2018_4684.pdf:ISMRM2018_4684.pdf:PDF},
title={Feasibility of Intravoxel Incoherent Motion ({IVIM}) Magnetic Resonance Imaging in Distinguishing Adenocarcinoma Originated from Uterine Corpus or Cervix},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4684.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Qi Zhang and Xiaoduo Yu and Han Ouyang and Lizhi Xie},
abstract={It is critical to distinguish adenocarcinoma arising from uterine corpus or cervix due to their different treatment methods and prognosis. However, it is hard to make a definite diagnosis based on MRI morphological characteristics, clinical examination., even the biopsy in some cases. The tumor biological information can be quantitatively evaluated by ADC and IVIM parameters(such as D, D* and f). Our study showed that ADC, D and f were significantly lower in the endometrial adenocarcinoma than the cervical adenocancinoma. IVIM parameters are promising biomarkers in predicting tumor origin of the uterine adenocarcinoma which contribute to treatment planning and prognosis evaluation.}
}
@inproceedings{ISMRM2018_4685,
annote={ISMRM2018_4685},
pages={4685},
file={ISMRM2018_4685.pdf:ISMRM2018_4685.pdf:PDF},
title={Application of Intravoxel incoherent motion diffusion-weighted imaging in the assessment of local aggressiveness of endometrial cancer},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4685.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Qi Zhang and Xiaoduo Yu and Han Ouyang and Dandan Zheng},
abstract={Local aggressiveness of endometrial cancer (EC) including the quantification of myometrial invasion, the exclusion of cervical stromal infiltration, lymphovascular space invasion (LVSI), etc, are closely related to EC risk classification, development, prognosis and surgical procedures. The ADC and IVIM-derived parameters can quantitatively assess tumor microstructure which is correlated to tumor development and aggressiveness. Our results showed that ADC and some of IVIM parameters demonstrated good diagnostic performance in the identification of deep myometrial invasion, cervical stromal infiltration and LVSI. IVIM DWI could provide valuable information about local aggressiveness of EC preoperatively which contribute to clinical decision-making and prognosis prediction.}
}
@inproceedings{ISMRM2018_4686,
annote={ISMRM2018_4686},
pages={4686},
file={ISMRM2018_4686.pdf:ISMRM2018_4686.pdf:PDF},
title={Texture analysis of multiparametric {MRI}: interobserver variability of texture features and associations with nodal status.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4686.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jose Angelo Udal Perucho and Elaine Yuen Phin Lee and Richard Du and Varut Vardhanabhuti and Queenie Chan},
abstract={Texture analysis of pre-treatment multiparametric MRI (mpMRI) consisting of diffusion-weighted MRI (DWI) and T2-weighted (T2W) texture features could be a promising and reproducible quantitative approach in assessing tumor heterogeneity in cervical cancer. We retrospectively studied forty treatment-naïve patients who had mpMRI examinations. We observed that around 30\% of texture features had low interobserver variability and that most of these features were from the Gray-Level Co-occurrence Matrix (GLCM) and Gray-Level Run Length Matrix (GLRLM). Furthermore, T2W features had moderate associations with pelvic lymph node (PLN) status.}
}
@inproceedings{ISMRM2018_4687,
annote={ISMRM2018_4687},
pages={4687},
file={ISMRM2018_4687.pdf:ISMRM2018_4687.pdf:PDF},
title={Diffusion kurtosis imaging for the diagnosis and prediction of response to treatment in high grade serous ovarian cancer},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4687.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Surrin Deen and Andrew N Priest and Mary A McLean and Andrew B Gill and Helena Earl and Christine Parkinson and Sarah Smith and Robin Crawford and John Latimer and Peter Baldwin and Helen Addley and Susan Freeman and Charlotte Hodgkin and Ilse Patterson and Mercedes Jimenez-Linan and James Brenton and Ferdia Gallagher},
abstract={Diagnosis of high grade serous ovarian cancer (HGSOC) requires a biopsy which is both invasive and does not reflect the heterogeneity of the disease. Diffusion kurtosis imaging (DKI) was performed on 23 treatment naïve ovarian cancer patients. Both mean Dapp (apparent diffusion) and mean Kapp (apparent kurtosis) were found to be significantly different in HGSOC compared to other types of epithelial cancer. Kapp was also significantly greater in the patients who went on to respond to chemotherapy treatment compared to non-responders. DKI may therefore aid in identifying HGSOC and in the selection of the best treatment for individual patients.}
}
@inproceedings{ISMRM2018_4688,
annote={ISMRM2018_4688},
pages={4688},
file={ISMRM2018_4688.pdf:ISMRM2018_4688.pdf:PDF},
title={Combining 2d {RF} excitation with multishot acquisition for reduced distortion imaging of the female pelvis.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4688.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Arnaud Guidon and Valentina Taviani and Holly Blahnik and Ann Shimakawa and Maggie M Fung and Nan-Kuei Chen and Ersin Bayram},
abstract={The combination of two-dimensional RF excitation with echo planar imaging has shown to be a useful technique for diffusion-weighted imaging of small anatomical features with high-resolution, such as in the pelvis or pancreas. However, compared to standard single shot dw-epi, the trade-off between resolution and matrix size becomes disadvantageous as the field of view increases. We propose to combine 2d RF excitation with multishot echo planar acquisition to enable high-resolution imaging with reduced distortion over larger FOV and present preliminary results obtained in the female pelvis.}
}
@inproceedings{ISMRM2018_4689,
annote={ISMRM2018_4689},
pages={4689},
file={ISMRM2018_4689.pdf:ISMRM2018_4689.pdf:PDF},
title={To explore the diagnostic value of Multi-parameter {MRI} in ovarian endometriosis},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4689.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ye Li and Ailian Liu and Qingwei Song and Lizhi Xie},
abstract={Endometriosis is a disease characterized by the invasion of active endometrial glands and stroma into any location other than the endometrium. Clinical symptoms of ovarian endometriosis include abdominal pain, irregular menstruation, abnormal vaginal bleeding and a tendency to malignant transformation. In this study, T1WI, T2WI, diffusion weighted imaging (DWI) and enhanced T2 star weighted angiography (ESWAN) MR measurements were performed to evaluate the feasibility of them in diagnosing ovarian endometriosis cysts and optimize the combination of the quantitative parameters of the above MRI sequences.}
}
@inproceedings{ISMRM2018_4690,
annote={ISMRM2018_4690},
pages={4690},
file={ISMRM2018_4690.pdf:ISMRM2018_4690.pdf:PDF},
title={Utility of histogram analysis of apparent diffusion coefficient maps in differential diagnosis of uterine sarcoma and degenerated uterine leiomyoma},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4690.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Mengna Huang and Xuemei Gao},
abstract={Histogram analysis of ADC values could provide more useful information than the mean ADC values and it has been proved to be valuable to evaluate tumor heterogeneity. We analyzed histogram features of ADC maps of uterine sarcoma and degenerated uterine leiomyoma. From our study, histogram analysis of ADC values has a high diagnostic efficiency in differential diagnosis of uterine sarcoma and degenerated uterine leiomyoma.}
}
@inproceedings{ISMRM2018_4691,
annote={ISMRM2018_4691},
pages={4691},
file={ISMRM2018_4691.pdf:ISMRM2018_4691.pdf:PDF},
title={Investigation of correlation between {IVIM} and {DCE}-{MRI} on uterine cervical carcinoma},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4691.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Xiaoduo Yu and Meng Lin and Yue Kong and Lizhi xie},
abstract={Perfusion was of great importance to access tumor properties. In this study, the potential correlations of perfusion parameters derived from IVIM (D*, f and f D*) and DCE-MRI (K
trans, K
ep and V
e) for uterine cervical carcinoma (UCC) were investigated and were compared between pathological types. D* and f D* were positively correlated with K
trans, K
ep and V
e, respectively. Adenocarcinoma had higher f, K
trans and K
ep values than those of squamous cell carcinoma. Therefore, IVIM, as a non-invasive method, has potential to replace DCE-MRI to accurately access tumor perfusion properties, especially when perfusion differs among different pathological types of UCC.}
}
@inproceedings{ISMRM2018_4692,
annote={ISMRM2018_4692},
pages={4692},
file={ISMRM2018_4692.pdf:ISMRM2018_4692.pdf:PDF},
title={Evaluating Female Pelvic Pain with {DISCO} {MRI}: Pilot study in Pelvic Congestion and Uterine Fibroids},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4692.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Rebecca Rakow-Penner and Adrija Mamidipalli and Albert Hsiao},
abstract={Pelvic congestion and uterine fibroids are two common causes of female pelvic pain that can be treated with image guided vascular embolization and often evaluated with MRI prior to treatment. Vascular as well as anatomic imaging are important in evaluation and treatment planning for these two disease processes. Differential sampling with Cartesian ordering (DISCO)-MRI is a technique that allows for both high temporal and spatial resolution. This abstract demonstrates the utility of DISCO-MRI in evaluation and treatment planning for pelvic congestion and uterine fibroids.}
}
@inproceedings{ISMRM2018_4693,
annote={ISMRM2018_4693},
pages={4693},
file={ISMRM2018_4693.pdf:ISMRM2018_4693.pdf:PDF},
title={Characterization of uterine artery geometry in normal pregnancy with time-of-flight angiography},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4693.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Eileen Hwuang and M. Dylan Tisdall and Nadav Schwartz and John A. Detre and Walter R. Witschey},
abstract={While measuring uterine artery (UtA) impedance is commonly used to assess for risk of preeclampsia and intrauterine growth restriction, little is understood about the remodeling process during gestation. An improved understanding of geometrical changes can lead to predictive biomarkers of adverse pregnancies. Here we present a method of measuring path length and curvature of the tortuous UtAs by segmentation and centerline extraction of time-of-flight MR angiography. We show in 8 pregnant subjects in the 2
nd and 3
rd trimester that this technique is feasible for investigating longitudinal trends of UtA remodeling and cases of maladaptation.}
}
@inproceedings{ISMRM2018_4694,
annote={ISMRM2018_4694},
pages={4694},
file={ISMRM2018_4694.pdf:ISMRM2018_4694.pdf:PDF},
title={Background-suppressed pulsed arterial spin labeling of placental perfusion at 1.5T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4694.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Eileen Hwuang and Zhengjun Li and Marta Vidorreta and Sudipto Dolui and M. Dylan Tisdall and Nadav Schwartz and Walter R. Witschey and John A. Detre},
abstract={We present the feasibility of measuring and quantifying placental blood flow in healthy pregnant subjects at 1.5T. We used a Flow Alternating Inverson Recovery (FAIR) scheme with background suppression. Using statistical parametric mapping, discrete regions of labeling were observed, likely corresponding to individual spiral artery distributions.}
}
@inproceedings{ISMRM2018_4695,
annote={ISMRM2018_4695},
pages={4695},
file={ISMRM2018_4695.pdf:ISMRM2018_4695.pdf:PDF},
title={Placental perfusion imaging using velocity-selective arterial spin labeling},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4695.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Zungho Zun and Catherine Limperopoulos},
abstract={Recently placental perfusion imaging using velocity-selective arterial spin labeling (VSASL) was applied in pregnancies complicated by fetal heart disease. Here we demonstrate the feasibility of performing VSASL in the human placenta and provide supporting evidence that is needed for validation of placental VSASL. In our results, placental VSASL generated significantly higher ASL signal than pseudocontinuous ASL, showed high reproducibility and demonstrated inflow-dependence. This study lays the groundwork for future investigation of placental perfusion imaging in pregnancies complicated by placental insufficiency.}
}
@inproceedings{ISMRM2018_4696,
annote={ISMRM2018_4696},
pages={4696},
file={ISMRM2018_4696.pdf:ISMRM2018_4696.pdf:PDF},
title={Free-breathing 3D quantitative susceptibility and T2* mapping of the human placenta: Initial experience in healthy pregnancies},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4696.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Zungho Zun and Catherine Limperopoulos},
abstract={Quantitative susceptibility mapping (QSM) is an emerging imaging technique for measuring magnetic susceptibility of tissue and may have the potential for depicting hypoxia, hemorrhage and calcification of the placenta. In this study we demonstrate simultaneous acquisition for QSM and T2* mapping of the human placenta using a 3D multi-echo gradient echo sequence with maternal free breathing. Compared to T2-weighted images, both QSM and T2* maps demonstrate more lobulated contrast in the placenta with lower susceptibility and higher T2* values within the lobules. This is the first study to investigate QSM of the human placenta in vivo.}
}
@inproceedings{ISMRM2018_4697,
annote={ISMRM2018_4697},
pages={4697},
file={ISMRM2018_4697.pdf:ISMRM2018_4697.pdf:PDF},
title={Textural analysis of the morbidly adherent placenta ({MAP}) from {MR} acquisitions},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4697.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Quyen N Do and Matthew A Lewis and Yin Xi and Ananth J Madhuranthakam and Timothy Ng and Robert E Lenkinski and Diane M Twickler},
abstract={The morbidly adherent placenta (MAP) is a significant obstetric condition and hysterectomy is often the outcome for severe cases. We applied region of interest (ROI)-based texture analysis on retrospective placental MR images in women with history of placenta previa and previous cesarean deliveries. Our goal was to evaluate the textural characteristics of placental tissue in proximity to previous surgical scars and compare findings to surgical outcomes. Several significant Haralick texture features were seen in placental ROI’s near previous cesarean scars in those women who underwent hysterectomy.}
}
@inproceedings{ISMRM2018_4698,
annote={ISMRM2018_4698},
pages={4698},
file={ISMRM2018_4698.pdf:ISMRM2018_4698.pdf:PDF},
title={Evaluation of Uterine and Placenta Motion throughout Early Gestation},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4698.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Thomas Martin and Xinzhou Li and Irish Del Rosario and Teresa Chanlaw and Tess Armstrong and Sherin Devaskar and Carla Janzen and Rinat Masamed and Holden Wu and Kyunghyun Sung},
abstract={When imaging the uterus and placenta, in pregnant patients, there are potential uterine contractions that compress the superior region of the uterus and can cause significant motion in the uterus and placenta. It is not well studied how much uterine contraction and other motion need to be accounted for during MRI scans in early gestation. In this study we observed and characterized uterine contractions and other bulk motion in pregnant women (gestational age 14-22weeks) using an image based template-matching program. This study can further help develop proper scanning protocols for MRI studies with pregnant patients to avoid potential motion artifacts.}
}
@inproceedings{ISMRM2018_4699,
annote={ISMRM2018_4699},
pages={4699},
file={ISMRM2018_4699.pdf:ISMRM2018_4699.pdf:PDF},
title={Placental Insufficiency Investigated with Multi-compartment Placental {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4699.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Andrew Melbourne and Rosalind Aughwane and David Owen and Magdalena Sokolska and Alan Bainbridge and David Atkinson and Jan Deprest and Giles Kendall and Tom Vercauteren and Anna David and Sebastien Ourselin},
abstract={Efficient exchange of oxygen and nutrients across the placenta is vital for a normally grown fetus. When remodelling of maternal arteries does not occur in early pregnancy the result is placental insufficiency and fetal growth restriction. Previous studies have shown differences in T2 relaxometry and IVIM between normal and FGR placentae. Here we use a combined T2R and IVIM signal model that separates signals from fetal and maternal blood pools over the whole placental volume. We show difference in T2R, ADC and maternal perfusion fraction, findings in keeping with previous literature and the pathophysiology of placental insufficiency.
}
}
@inproceedings{ISMRM2018_4700,
annote={ISMRM2018_4700},
pages={4700},
file={ISMRM2018_4700.pdf:ISMRM2018_4700.pdf:PDF},
title={Magnetic Resonance Elastography and model diffusion-weighted imaging of Autoimmune Pancreatitis: A Preliminary Study},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4700.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yu Shi and Lizhuo Cang and Xiaoqi Wang and Yanqing Liu and Min Wang and Ruoyun Ji and Qiyong Guo},
abstract={Autoimmune pancreatitis (AIP) is a benign process characterized by lymphoplasmacytic infiltration and massive fibrosis.}
}
@inproceedings{ISMRM2018_4701,
annote={ISMRM2018_4701},
pages={4701},
file={ISMRM2018_4701.pdf:ISMRM2018_4701.pdf:PDF},
title={Comparison of six diffusion-weighted imaging models for the detection of treatment effects in pancreatic cancer patients},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4701.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Oliver J Gurney-Champion and Remy Klaassen and Marc R W Engelbrecht and Jaap Stoker and Johanna W Wilmink and Marc G Besselink and Arjan Bel and Geertjan van Tienhoven and Hanneke W M van Laarhoven and Aart J Nederveen},
abstract={
We tested the performance of six diffusion models for detecting effects from treatment in pancreatic ductal adenocarcinoma. All models, including the mono-exponential fit, were able to detect parameter changes after treatment in individual patients for five out of nine patients. For multi-parametric models treatment affected different parameters for different patients, allowing potentially discriminating between types of effects. The pseudo diffusion coefficient values from the intravoxel incoherent motion model were in line with instant dephasing due to bulk motion rather than capillary perfusion, limiting its clinical interpretation. Using two mono-exponential fits, one at low and one at high b-values, was preferred.}
}
@inproceedings{ISMRM2018_4702,
annote={ISMRM2018_4702},
pages={4702},
file={ISMRM2018_4702.pdf:ISMRM2018_4702.pdf:PDF},
title={Imaging beta-cell function in the mouse pancreas with an implanted imaging window by {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4702.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Veronica Clavijo Jordan and Xiaodong Wen and Filip Bochner and Su-Tang Lo and Andre F. Martins and Sara Chirayil and Michal Neeman and A. Dean Sherry},
abstract={We have successfully implanted an imaging window onto the mouse abdomen to locate and hold the tail of the pancreas in place. By use of this MR-compatible window we were able to show with MRI and a Gd-based zinc sensor the non-uniform regional secretion of zinc and insulin as a response to glucose in the tail of the mouse pancreas. This surgical technique and imaging technology could be used to successfully monitor beta-cell function longitudinally through the development of the various diseases of the endocrine pancreas with MRI.}
}
@inproceedings{ISMRM2018_4703,
annote={ISMRM2018_4703},
pages={4703},
file={ISMRM2018_4703.pdf:ISMRM2018_4703.pdf:PDF},
title={Diffirentiation Between Pancreatic Ductal Adenocarcinoma and Neuroendocrine Tumors :Using Whole-tumor Histogram Analysis of Non-Gaussian Distribution {DWI} Models},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4703.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jiali Li and Daoyu Hu and Zhen Li},
abstract={The purpose of this paper is to explore a most helpful DWI mathematical models in differenting pancreatic ductal adenocarcinoma and neuroendocrine tumors. All parameters of three models(monoexponential, biexponential and stretched exponential) were obtained from a histogram analysis based on the entire tumor. By comparing diagnostic performance, the significant parameters that have the highest diagnostic performance were selected to the most helpful parameters. The results of this study showed that IVIM-DWI model may be the most suitable for differenting pancreatic tumors.}
}
@inproceedings{ISMRM2018_4704,
annote={ISMRM2018_4704},
pages={4704},
file={ISMRM2018_4704.pdf:ISMRM2018_4704.pdf:PDF},
title={Treatment effect of autoimmune pancreatitis: evaluation with T1 mapping},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4704.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Liang Zhu and Hua-dan Xue and Zhao-yong Sun and Marcel Dominik Nickel and Tianyi Qian and Zheng-yu Jin},
abstract={This prospective study aims to evaluate the T1 relaxation time of autoimmune pancreatitis (AIP) in the native state and after corticosteroid treatment (CST). Thirty-four patients with AIP and twenty control subjects received pancreatic MR including T1 mapping. All AIP patients had T1 mapping data before and after CST. It turned out that the inflamed pancreatic parenchyma had significantly elongated T1 relaxation time and after 4-12 weeks of CST, the T1 relaxation time shortened significantly towards normalization, in keeping with the serum biomarkers of disease activity. Therefore MR T1 mapping is a noninvasive, quantitative method to monitor AIP treatment effect.}
}
@inproceedings{ISMRM2018_4705,
annote={ISMRM2018_4705},
pages={4705},
file={ISMRM2018_4705.pdf:ISMRM2018_4705.pdf:PDF},
title={Intravoxel Incoherent Motion Diffusion-weighted {MR} Imaging of Solid Pancreatic Masses: reproducibility and usefulness for characterization},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4705.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Riccardo De Robertis and Nicolò Cardobi and Robert Grimm and Berthold Kiefer and Alto Stemmer and Marco Zanirato and Mirko D'Onofrio},
abstract={Overall intraobserver agreement for ADC- and IVIM-derived parameters was excellent. Perfusion-related IVIM-derived parameters are the most reliable for differentiation between pancreatic ductal adenocarcinoma and neuroendocrine neoplasms. No significant differences were found between ADC- and IVIM-derived parameters of mass-forming pancreatitis and carcinoma.}
}
@inproceedings{ISMRM2018_4706,
annote={ISMRM2018_4706},
pages={4706},
file={ISMRM2018_4706.pdf:ISMRM2018_4706.pdf:PDF},
title={Optimal combinations of b-values in computed {DWI} for pancreatic cancer detection},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4706.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Koji Tokunaga and Shigeki Arizono and Hiroyoshi Isoda and Hironori Shimizu and Koji Fujimoto and Kaori Togashi},
abstract={There has been no previous report on the optimal combinations of b-values to obtain computed DWI (cDWI) with b-values above 1000 s/mm2 to evaluate pancreatic cancer. This retrospective study involved 30 pancreatic cancer patients with tumor associated pancreatitis. We aimed to evaluate the optimal combination of b-values to obtain cDWI with b-value of 1500 s/mm2 from the combinations of b-values between 0 and 500 s/mm2 (cDWI0-500), 0 and 1000 s/mm2 (cDWI0-1000), 500 and 1000 s/mm2 (cDWI500-1000) and all b-values (cDWIALL). Only cDWI0-1000 demonstrated statistically higher tumor detectability compared to measured DWI, while image quality was preserved in cDWI0-1000 and cDWIALL.}
}
@inproceedings{ISMRM2018_4707,
annote={ISMRM2018_4707},
pages={4707},
file={ISMRM2018_4707.pdf:ISMRM2018_4707.pdf:PDF},
title={Age dependency of T1 and T2 values in healthy pancreas measured at 7 Tesla},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4707.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Mariska Damen and Maarten S. van Leeuwen and Peter R. Luijten and Andrew Webb and Dennis WJ Klomp and Catalina S. Arteaga de Castro},
abstract={Age dependency of T1 and T2 times of the healthy pancreas at 7 Tesla with a multi-transmit system was investigated for MRI protocol optimization of the pancreas. Three age groups were measured (21 -25 yo, 26 -39 yo and 40 -72 yo). Measurements resulted in average T2 times of 52 ms, 97 ms and 127 ms for the 3 different age groups respectively, revealing an age dependency of the T2 relaxation times. Average T1 times were 856 ms, 899 ms and 858 ms for each age group respectively. No age dependency was observed for the T1 relaxation times.}
}
@inproceedings{ISMRM2018_4708,
annote={ISMRM2018_4708},
pages={4708},
file={ISMRM2018_4708.pdf:ISMRM2018_4708.pdf:PDF},
title={High-Resolution Intravoxel Incoherent Motion ({IVIM}) diffusion-weighted {MR} imaging for the characterization of periampullary lesions},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4708.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Haixia Yu and Chuangliang Chen and Dapeng Shi and Robert Grimm and Tianyi Qian},
abstract={This study aimed to investigate the clinical diagnostic utility of ZOOMit-DWI-based IVIM imaging technology[1,2] for periampullary lesions. Forty-one patients, comprising cancer of the pancreatic head (n = 6), chronic pancreatitis (n = 9), ampullary adenocarcinoma (n = 9) and distal bile duct carcinoma (n = 17) and 28 healthy volunteers were enrolled. Our results showed that the perfusion fraction (f) of the IVIM-derived parameter has the potential to distinguish between cancer of the pancreatic head, other lesions and normal tissue in the periampullary regions by using the zoomed DW imaging, which has the capacity to overcome some of the limitations of conventional MRI of the pancreas.}
}
@inproceedings{ISMRM2018_4709,
annote={ISMRM2018_4709},
pages={4709},
file={ISMRM2018_4709.pdf:ISMRM2018_4709.pdf:PDF},
title={Evaluation of Extracellular Volume ({ECV}) Fraction of the Normal Pancreas and Correlation with Biophysical Parameters},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4709.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Temel Tirkes and Kumaresan Sandrasegaran and Eugene P Ceppa and Chen Lin},
abstract={ECV fraction can be a very useful imaging tool for non-invasive evaluation of solid organ pathologies and is probably underutilized in abdominal imaging. There are potentially several clinical applications of ECV in the abdomen such as evaluation of chronic pancreatitis or chronic liver disease. In this study, we computed the ECV fraction of the pancreas in 60 healthy cohorts and determined that ECV fraction of the normal pancreas is 0.26 (± 0.08). ECV fraction is not influenced by pancreatic steatosis or patient’s gender, however gradually increases with age.}
}
@inproceedings{ISMRM2018_4710,
annote={ISMRM2018_4710},
pages={4710},
file={ISMRM2018_4710.pdf:ISMRM2018_4710.pdf:PDF},
title={Value of whole-tumor histogram-based texture analysis of baseline {ADC} map in prediction of tumor response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4710.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={lanqing Yang and bing Wu},
abstract={There has been increasing interest in quantitative methods to excavate more information than traditional descriptive features, facilitated by the availability of texture analysis software platforms. By doing whole-tumor histogram-based texture analysis on pre-treatment ADC map, histogram parameters reflecting the pixel distribution of ROIs were derived. Our study found that LARC that achieved pCR after NCRT appeared less heterogeneous on ADC map and had lower high percentile pre-treatment ADC values. Whole-tumor histogram parameters of pre-treatment ADC map were feasible to predict pCR in LARC, including the absolute value of relative deviation, frequency size, quantile 75\%, 90\% and 95\% of ADC value histogram.}
}
@inproceedings{ISMRM2018_4711,
annote={ISMRM2018_4711},
pages={4711},
file={ISMRM2018_4711.pdf:ISMRM2018_4711.pdf:PDF},
title={Splenic {MR} Elastography in Prediction of Esophageal Varices Grading},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4711.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Chen-Te Chou and Ran-Chou Chen},
abstract={To investigate the relationship between splenic MR elastography (MRE) and esophageal varices (EV). 167 patients underwent endoscopy and abdominal MR examination within 3-months interval were enrolled. MRE was performed with passive driver on right and left chest wall separately. The mean stiffness value of liver and spleen was determined. A good correlation between splenic stiffness and EV, but no correlation for liver stiffness was found. Our results demonstrated that spleen stiffness measured by MRE was significant correlated with EV grading. With 9.77 kPa spleen stiffness might be helpful in predicting presence of EV for patients with chronic liver disease.}
}
@inproceedings{ISMRM2018_4712,
annote={ISMRM2018_4712},
pages={4712},
file={ISMRM2018_4712.pdf:ISMRM2018_4712.pdf:PDF},
title={Automated Localization and Segmentation of Locally-Advanced Rectal Cancer Based on T2, {DWI} and {DCE} Multi-Parametric {MRI} Using Deep Learning},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4712.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yang Zhang and Liming Shi and Xiaonan Sun and Tianye Niu and Ning Yue and Peter Chang and Daniel Chow and Melissa Khy and Tiffany Kwong and Jeon-Hor Chen and Min-Ying Su and Ke Nie},
abstract={A deep learning method using the convolutional neural network (CNN) was implemented to segment rectal cancer in 48 patients. Six sets of images (one T2, Two DWI, three DCE) were used as inputs. The Dice Similarity Coefficient (DSC) was used to evaluate results generated by the CNN algorithm compared to the manually outlined ground truth. When the search was done on the entire image the mean DSC was 0.64 and the errors were mainly from tissues outside the rectum. The rectum could be easily segmented and when the search was confined within 1.5 times of rectal area, the DSC was improved to 0.75.}
}
@inproceedings{ISMRM2018_4713,
annote={ISMRM2018_4713},
pages={4713},
file={ISMRM2018_4713.pdf:ISMRM2018_4713.pdf:PDF},
title={Differentiation between Intestinal-type and Pancreatobiliary-type Periampullary Carcinoma and Prediction of Lymphatic Metastasis: Whole-Lesion Diffusion-Weighted Imaging Histogram Analysis},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4713.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jingyu Lu and Zhen Li and Daoyu Hu},
abstract={Pancreatobiliary versus intestinal histologic type of differentiation is an independent prognostic factor in resected periampullary adenocarcinoma. To differentiate these two histologic type proactively before surgery, we tried to use whole-lesion histogram analysis of apparent diffusion coefficient (ADC) derived from diffusion-weighted imaging . Entropy was significantly lower in pancreatobiliary-type periampullary carcinoma and achieved the best diagnostic performance. ADC value was relatively lower in pancreatobiliary-type. No significant difference was shown between lymph node metastasis positive and negative group. So we hypothesized that ADC histogram parameters might help to differentiate these two histologic type without the influence of lymph nodal involvement.}
}
@inproceedings{ISMRM2018_4714,
annote={ISMRM2018_4714},
pages={4714},
file={ISMRM2018_4714.pdf:ISMRM2018_4714.pdf:PDF},
title={Value of R2* for predicting the response of locally advanced rectal cancer to neoadjuvant chemoradiation therapy},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4714.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Hongliang Sun and Yanyan Xu and Queenie Chan and Wu Wang},
abstract={Neoadjuvant chemoradiation therapy (CRT) followed by surgery has been established as the standard for locally advanced rectal cancer. The treatment response after CRT is normally evaluated by MRI. However, MRI morphology techniques suffer from limitations in the interpretation of fibrotic scar tissue and inflammation. Several studies have demonstrated that sensitivity to chemoradiotherapy is related to the oxygenation status of the tumor. It has been shown that the slight increase in T2* signals from paramagnetic deoxyhemoglobin can be used for reflecting the tumor oxygenation status. Therefore, R2*(=1/T2*) might have the potential to be a predictor of prognosis and treatment response for patients with locally advanced rectal cancer.}
}
@inproceedings{ISMRM2018_4715,
annote={ISMRM2018_4715},
pages={4715},
file={ISMRM2018_4715.pdf:ISMRM2018_4715.pdf:PDF},
title={Evaluating Response of Locally Advanced Gastric Adenocarcinoma to Neoadjuvant Chemotherapy using Intravoxel Incoherent Motion {MRI}: A Preliminary study},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4715.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yongjian Zhu and Liming Jiang and Ying Li and Lizhi Xie},
abstract={Intravoxel incoherent motion (IVIM) diffusion-weighted magnetic resonance imaging (DW-MRI) has been applied in research of different cancers, however its potential in gastric cancer has not been fully explored. In this study, we explored the value of IVIM parameters in evaluating the response to chemotherapy in gastric cancer. We found that the D and f values showed good diagnostic performance by differentiating responders from nonresponders, this could provide effective help for the choice of clinical treatment.}
}
@inproceedings{ISMRM2018_4716,
annote={ISMRM2018_4716},
pages={4716},
file={ISMRM2018_4716.pdf:ISMRM2018_4716.pdf:PDF},
title={Conical Ultrashort {TE} ({UTE}) {MRI} in the evaluation of pediatric acute appendicitis},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4716.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Zhibo Xiao and Albert T Roh and Joseph Y Cheng and Shreyas S Vasanawala and Andreas M Loening},
abstract={To reduce patient exposure to the ionizing radiation of CT, hospitals are increasing MRI usage in the evaluation of suspected acute appendicitis, particularly in the pediatric population. Our retrospective review of 84 pediatric patients assessed contrast-enhanced conical Ultrashort TE (UTE) of the pelvis. UTE demonstrated better qualitative Signal-to-Noise Ratio (SNR), fewer artifacts and better overall image quality than both a 3D dual-echo SPoiled GRadient echo (SPGR) sequence and a free-breathing high-resolution 3D SPGR. Our study concluded that UTE is feasible in the evaluation of the pelvis for pediatric acute appendicitis.}
}
@inproceedings{ISMRM2018_4717,
annote={ISMRM2018_4717},
pages={4717},
file={ISMRM2018_4717.pdf:ISMRM2018_4717.pdf:PDF},
title={Direct visualization of physiological intestinal flow using unenhanced {MR} imaging with spin labeling},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4717.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jun Isogai and Mitsue Miyazaki and Kenji Yodo and Michitaka Suzuki and Takashi Yamada and Jun Kaneko},
abstract={Assessment of motility and propagation of the small bowel has been reported using conventional contrast x-ray techniques with unavoidable ionizing radiation and recent MR imaging. However, MR enteroclysis and enterography require a discomforted nasoenteric intubation and an oral administration of large volumes of enteric contrast materials, respectively. Unenhanced MR imaging with a spin labeling technique provides direct visualization of physiological intestinal intraluminal flow related to bowel peristalsis.}
}
@inproceedings{ISMRM2018_4718,
annote={ISMRM2018_4718},
pages={4718},
file={ISMRM2018_4718.pdf:ISMRM2018_4718.pdf:PDF},
title={Increased small bowel permeability is associated with significantly increased T2 measures of the small bowel wall.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4718.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Hannah G Williams and Robert Scott and Luca Marciani and Catherine Ortori and Guruprasad Aithal and Penny A Gowland and Caroline L Hoad},
abstract={Available techniques to measure in-vivo bowel permeability are inadequate for stratifying patients to identify those at risk of complications. T2 weighted measurements in Crohn’s disease are sensitive markers of small bowel wall structural changes and could potentially be indicators of permeability. We have developed quantitative T2 measures of the small bowel wall to characterize changes associated with increased permeability induced by indomethacin. We found a significant increase in quantitative measures of T2 of the small bowel wall associated with increased permeability provoked by indomethacin.}
}
@inproceedings{ISMRM2018_4719,
annote={ISMRM2018_4719},
pages={4719},
file={ISMRM2018_4719.pdf:ISMRM2018_4719.pdf:PDF},
title={The Radiomic Signature as a Prognostic Biomarker for Locally Advanced Rectal Cancer},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4719.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yuchen Zhang and Yankai Meng and Hongmei Zhang and Chunwu Zhou and Di Dong and Mengjie Fang and Yali Zang and Zhenyu Liu and Jie Tian and Di Dong and Di Dong and Di Dong},
abstract={Radiomics uses a large number of medical imaging features and can demonstrate voxel-wise intratumor heterogeneity. We calculated the radiomic signature for each patient using a weighted linear combination of the radiomic features selected by machine learning methods. The study endpoint was DFS, defined as the interval between TME surgery and disease progression, which included tumor local recurrence, distant metastasis, or death, or the date of the last follow-up visit (censored). The association between the radiomic signature and DFS was explored. Then, the three models were built to estimate the DFS in patients.}
}
@inproceedings{ISMRM2018_4720,
annote={ISMRM2018_4720},
pages={4720},
file={ISMRM2018_4720.pdf:ISMRM2018_4720.pdf:PDF},
title={Rectal Cancer: Comparison of {MRI} Characteristics and Texture Analysis Between Different Tumor {KRAS} Mutation Status},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4720.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yanyan Xu and Hongliang Sun and Queenie Chan and Wu Wang},
abstract={KRAS mutations are well known as predictive markers of resistance to epidermal growth factor receptor-targeted antibodies in rectal cancers. Approximately 30\%-40\% colorectal cancers are observed with KRAS mutation and rectal cancer accounts for 30\%-35\% among CRC. The pre-operative neoadjuvant therapy including anti-EGFR chemotherapy demonstrated robust value is the current trend in the management of rectal cancer. Therefore, it is important to select suitable patients who would benefit from the aggressive multimodality approaches and tailor individual treatment to better combat disease. Currently, few data are available regarding the potential relationship between MRI characteristics and genetic biomarkers.}
}
@inproceedings{ISMRM2018_4721,
annote={ISMRM2018_4721},
pages={4721},
file={ISMRM2018_4721.pdf:ISMRM2018_4721.pdf:PDF},
title={Rapid and noninvasive detection and dynamic quantification of gut bleeds with Magnetic Particle Imaging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4721.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Elaine Yu and Prashant Chandrasekharan and Ran Berzon and Xinyi Y Zhou and Zhi Wei Tay and R Matthew Ferguson and Amit P Khandhar and Scott J Kemp and Bo Zheng and Patrick Goodwill and Michael F Wendland and Kannan M Krishnan and Spencer Behr and Jonathan Carter and Steven Conolly},
abstract={Magnetic Particle Imaging (MPI) is a novel, high-contrast and quantitative imaging modality that directly detects superparamagnetic iron oxide nanoparticle (SPIO) tracers. These SPIOs have been previously used as a MRI contrast agent. However, with MRI SPIOs are limited by poor specificity and difficulty associated with quantifying the negative signal. Due to its direct detection, high sensitivity and positive contrast, MPI is uniquely poised as a clinically translatable platform for vascular imaging, including gastrointestinal (GI) bleed detection. Here we present in vivo GI bleed detection using long-circulating SPIOs as the vascular agent in a mouse model of Familial Adenomatous Polyposis.}
}
@inproceedings{ISMRM2018_4722,
annote={ISMRM2018_4722},
pages={4722},
file={ISMRM2018_4722.pdf:ISMRM2018_4722.pdf:PDF},
title={Diffusion-Weighted {MR} Imaging of rectal cancer with A Fractional Order Calculus Model},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4722.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yanfen Cui and Zhizheng Zhuo and Xiaotang Yang},
abstract={A novel non-Gaussian diffusion model based on fractional order calculus (FROC) were successfully applied to diffusion MRI of rectal cancer. Statistically significant differences in D and β values are observed between rectal cancer and villous adenoma (p < 0.001), indicating that individual or combined parameters from the FROC diffusion model may be useful as imaging biomarkers in predicting the biological properties of rectal cancer in clinical practice.}
}
@inproceedings{ISMRM2018_4723,
annote={ISMRM2018_4723},
pages={4723},
file={ISMRM2018_4723.pdf:ISMRM2018_4723.pdf:PDF},
title={{MRI} Texture Analysis in Predicting Treatment Response to Neoadjuvant Chemoradiotherapy in Rectal Cancer},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4723.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={yankai meng and hongmei zhang and chunwu zhou},
abstract={To evaluate the importance of MRI texture analysis in prediction and early assessment of treatment response before and early neoadjuvant chemoradiotherapy (nCRT) in patients with locally advanced rectal cancer (LARC). This retrospective study comprised of 59 patients. The tumoral texture parameters were compared between pre- and early nCRT. Area Under receiver operating characteristic (ROC) Curves [AUCs] were used to compare the diagnostic performance of statistically significant difference parameters and logistic regression analysis predicted probabilities for discriminating responders and nonresponders. Texture parameters as imaging biomarkers have the potential to prediction and early assessment of tumoral treatment response to neoadjuvant chemoradiotherapy in patients with LARC.
}
}
@inproceedings{ISMRM2018_4724,
annote={ISMRM2018_4724},
pages={4724},
file={ISMRM2018_4724.pdf:ISMRM2018_4724.pdf:PDF},
title={Fully Automated Liver Fat Assessment using Multi-Atlas Segmentation},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4724.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Joel Kullberg and Taro Langner and Filip Malmberg and Anders Hedström and Jonathan Andersson and Carl Sjöberg and Lars Lind and Håkan Ahlström},
abstract={Non-alcoholic fatty liver disease (NAFLD) has become the most common liver disease with an estimated global prevalence of 25\%. Its link to metabolic, cardiovascular and more severe forms of liver disease presents a major challenge for future healthcare. MRI allows accurate quantification of liver fat concentration. Since manual delineation of the liver is time-consuming, measurements are typically performed in small subjectively selected regions of interest which limits accuracy and precision. This work presents an automated method for liver fat assessment using multi-atlas segmentation. Evaluation with measurements using manual liver segmentation (n=306) demonstrates excellent agreement (R=1.000, difference -0.03\%, p=0.001).}
}
@inproceedings{ISMRM2018_4725,
annote={ISMRM2018_4725},
pages={4725},
file={ISMRM2018_4725.pdf:ISMRM2018_4725.pdf:PDF},
title={Effect of polyphenols during a high-fat diet enhanced with chemical shift-encoded {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4725.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Angéline Nemeth and Hélène Ratiney and Benjamin Leporq and Kévin Seyssel and Bérénice Segrestin and Pierre-Jean Valette and Martine Laville and Olivier Beuf},
abstract={In this study, 42 healthy male underwent a randomized, double blinded, parallel-group trial with either polyphenols or placebo during 31 days of high-carbohydrate and high-fat overfeeding. Changes in visceral, subcutaneous adipose tissue volumes and liver fat were measured using multi-gradient echo sequence. Visceral, subcutaneous adipose tissue volumes and liver fat increased significantly during overfeeding. The ratio VAT/SAT increased during overfeeding for the placebo group whereas this ratio slightly decreased for the polyphenol group.}
}
@inproceedings{ISMRM2018_4726,
annote={ISMRM2018_4726},
pages={4726},
file={ISMRM2018_4726.pdf:ISMRM2018_4726.pdf:PDF},
title={Assessment of liver dysfunction with 1H-{MRS} and relaxometry in a murine model of cerebral malaria},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4726.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Teodora-Adriana PERLES-BARBACARU and Emilie PECCHI and Yann LE FUR and Alexandre VINTILA and Monique BERNARD and Angèle VIOLA},
abstract={Cerebral malaria (CM) is the most lethal complication of Plasmodium infection and may be associated with multiple organ failure. We have investigated liver microstructure and metabolism in a widely-used murine model of CM induced with Plasmodium Berghei ANKA using in vivo anatomical MRI, relaxometry and localized proton spectroscopy at 11.75T. Our results show an increase in liver T
2 value with CM progression. This increase is apparently linked to a reduction in tissue water content and to lipid remodeling. These alterations could be related to the clinical degradation occurring at the severe stage of the disease as well as to a direct effect of the parasite on the liver.}
}
@inproceedings{ISMRM2018_4727,
annote={ISMRM2018_4727},
pages={4727},
file={ISMRM2018_4727.pdf:ISMRM2018_4727.pdf:PDF},
title={Validation of gadoxetate dynamic contrast-enhanced {MRI} to assess liver function in rats with liver fibrosis: comparison with shear wave elastography and indocyanine green test},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4727.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jimi Huh and Su Jung Ham and Young Chul Cho and Seul-I Lee and Jisuk Park and Chul Woong Woo and Yoonseok Choi and Dong-Cheol Woo and Kyung Won Kim},
abstract={Non-invasive imaging evaluation of the liver fibrosis and liver function has been gaining emphasis currently. In preclinical trial with animal liver fibrosis model, the gadoxetate DCE-MRI is quite feasible to evaluate histopathologic liver fibrosis and physiologic liver function in a non-invasive and repeatable manner. The best MRI index would be the iAUC-15, which is better than kPa on SWE.}
}
@inproceedings{ISMRM2018_4728,
annote={ISMRM2018_4728},
pages={4728},
file={ISMRM2018_4728.pdf:ISMRM2018_4728.pdf:PDF},
title={Measuring hepatocyte transplant success using gadoxetate enhanced {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4728.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Christiane Mallett and Jeremy Hix and Kate Hammond and Alexander Wolf and Erik Shapiro},
abstract={We used gadoxetate-enhanced MRI to monitor a mouse model of liver failure and hepatocyte transplantation.}
}
@inproceedings{ISMRM2018_4729,
annote={ISMRM2018_4729},
pages={4729},
file={ISMRM2018_4729.pdf:ISMRM2018_4729.pdf:PDF},
title={{PEG}-{FGF}21 Variant Improves Hepatic Steatosis in a Mouse Model of {NASH} as Determined by Quantitative Water-fat {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4729.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Haiying Tang and Matthew Fronheiser and Stephanie Boehm and Adrienne Pena and Shorts Andrea and Bradley Zinker and John Krupinski and Harold Malone and Patrick Chow and Edgar Charles and Shuyan Du and Wendy Hayes},
abstract={Non-alcoholic fatty liver disease (NAFLD) ranges from simple fatty liver to steatohepatitis (NASH) to cirrhosis. In the present study, we implemented a water-fat MRI using the gradient-reversal technique to quantify the hepatic proton density fat-fraction (PDFF), for assessment of hepatic steatosis in a diet-induced mouse model of NASH. We compared the quantitative water-fat MRI technique with conventional Dixon method and single-voxel MR spectroscopy (MRS) and correlated the MRI-PDFF with histology and biochemical triglyceride (TG) content. Lastly, the effects of a PEGylated-FGF21 variant (PEG-FGF21v) on hepatic steatosis in the mouse model was evaluated using the water-fat MRI technique.}
}
@inproceedings{ISMRM2018_4730,
annote={ISMRM2018_4730},
pages={4730},
file={ISMRM2018_4730.pdf:ISMRM2018_4730.pdf:PDF},
title={Preliminary Study on the Feasibility of Simultaneously Measuring Hepatic Stiffness and Separate Water/Fat Signal Using Dual-Echo, Dixon, Spoiled-Gradient-Echo, Magnetic Resonance Elastography},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4730.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yuan Le and Joshua Trzasko and Kevin Glaser and Yuxiang Zhou and William Pavlicek and Joseph M. Hoxworth and Bradley D. Bolster Jr. and Joel P. Felmlee and Richard L. Ehman and Jun Chen},
abstract={A novel dual-echo, Dixon MR Elastography technique was developed to simultaneously measure the liver stiffness and separate fat/water signal. Phantom tests showed that the fat signal fraction and the stiffness measured with this technique were consistent with the values measured with separate MR spectroscopy and standard MR Elastography acquisitions. Promising results were also obtained in a healthy volunteer.}
}
@inproceedings{ISMRM2018_4731,
annote={ISMRM2018_4731},
pages={4731},
file={ISMRM2018_4731.pdf:ISMRM2018_4731.pdf:PDF},
title={Magnetic resonance cholangiopancreatography using optimized integrated combination with parallel imaging and compressed sensing technique compared with conventional {MRCP}.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4731.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Nobuyuki Kawai and Satoshi Goshima and Kimihiro Kajita and Tomoyuki Okuaki and Masatoshi Honda and Hiroshi Kawada and Yoshifumi Noda and Yukichi Tanahashi and Shoma Nagata and Masayuki Matsuo},
abstract={MR cholangiopancreatography (MRCP) plays an essential role in the noninvasive assessment of the biliary and pancreatic duct systems. The current respiratory-triggered three-dimensional turbo spin-echo MRCP sequence has an excellent duct-to-periductal tissue contrast, however, the long acquisition time and motion artifacts due to the various depth of patients’ breathing limit the benefit of this sequence. We assessed prototype sequence using optimized integrated combination with parallel imaging and compressed sensing technique (Compressed-SENSE) for MRCP. Our results demonstrated that Compressed-SENSE technique enabled significant reduction of acquisition time without image quality degradation compared with conventional method.}
}
@inproceedings{ISMRM2018_4732,
annote={ISMRM2018_4732},
pages={4732},
file={ISMRM2018_4732.pdf:ISMRM2018_4732.pdf:PDF},
title={{MR} elastography as a noninvasive marker for liver fibrosis in chronic hepatitis B patients: Comparisons with serum fibrosis markers},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4732.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Bohyun kim and Hye Jin Kim and Jei Hee Lee and Hyo Jung Cho and Jai Keun Kim},
abstract={Among various noninvasive methods for liver fibrosis quantification, we compared liver stiffness measured from MR elastography and multiple serum fibrosis markers including APRI, FIB-4 and King' score for liver fibrosis prediction. Our results showed than MR elastography performed better than serum fibrosis indices in discerning clinically significant fibrosis (≥ F3) and liver cirrhosis (≥ F4) in chronic hepatitis B patients.}
}
@inproceedings{ISMRM2018_4733,
annote={ISMRM2018_4733},
pages={4733},
file={ISMRM2018_4733.pdf:ISMRM2018_4733.pdf:PDF},
title={Differential diagnosis of hepatic iron contents in simple steatosis and nonalcoholic steatohepatitis using multiecho Dixon magnetic resonance imaging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4733.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Tae-Hoon Kim and Chang-Won Jeong and Hong Young Jun and Youe Ree Kim and Ju Young Kim and SiHyeong Noh and JiEon Kim and Young Hwan Lee and Kwon-Ha Yoon},
abstract={Non-invasive monitoring liver iron content (LIC) is critical for clinical management or effective therapeutic strategy of patients because the increment of iron accumulation within the liver may contribute to liver disease via the production of reactive oxygen species. Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease in the United States and is reported to between 10\% and 30\%, with similar rates reported from Europe and Asia. However, it is difficult to distinguish the sub-groups in NAFLD, especially simple steatosis (SS) and non-alcoholic steatohepatitis (NASH), unless by liver biopsy. Therefore, it is important to monitor liver iron content (LIC) in NASH patients for clinical management or effective therapeutic strategy of patients.}
}
@inproceedings{ISMRM2018_4734,
annote={ISMRM2018_4734},
pages={4734},
file={ISMRM2018_4734.pdf:ISMRM2018_4734.pdf:PDF},
title={Feasibility of Assessing the Nonlinear Mechanical behaviors of Liver with {MR} Elastography ({MRE})},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4734.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ziying Yin and Bogdan Dzyubak and Jiahui Li and Kevin J. Glaser and Sudhakar Venkatesh and Armando Manduca and Richard L Ehman and Meng Yin},
abstract={This is a feasibility study for assessing the nonlinear mechanical behaviors of the liver while experiencing different degrees of mechanical preloads. The different loading conditions were induced by 1) diaphragm movement in a view-sharing free-breathing 2D-EPI-MRE acquisition; 2) end-expiration versus end-inspiration states in a breath-held 3D-EPI-MRE acquisition. We observed intriguing stiffness variation synchronized with the breathing pattern in the free-breathing MRE and a difference between end-expiration and end-inspiration liver stiffness in the breath-held MRE. The promising results demonstrated that the free-breathing and/or breath-hold liver MRE at different breathing states can be useful for the assessment of nonlinear mechanical tissue behaviors.}
}
@inproceedings{ISMRM2018_4735,
annote={ISMRM2018_4735},
pages={4735},
file={ISMRM2018_4735.pdf:ISMRM2018_4735.pdf:PDF},
title={Cross-validation of Multi-parametric {MRI} in Characterizing Steatosis, Inflammation and Fibrosis in Nonalcoholic Steatohepatitis ({NASH}) and Alcohol Hepatitis ({AH}) Mouse Models},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4735.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ziying Yin and Rosa Martin Mateos and Jiahui Li and Vikas K. Verma and Kevin J. Glaser and Amy S. Mauer and Harmeet Malhi and Vijay Shah and Richard L Ehman and Meng Yin},
abstract={In this preliminary study, we cross-validated the usefulness of multi-parametric MRI (fat fraction, liver stiffness and damping ratio) in assessing the disease development and treatment response in both NASH and AH mouse models. Fat fraction has excellent agreement with the steatosis changes in both progressive and regressive AH and NASH models. In AH models, hepatic inflammation indicators have shown promising trends that well agreed each other in ALT and damping ratio. For the NASH model, both liver stiffness and damping ratio increased progressively in the fast-food-diet group and the changes of stiffness was consistent with the end-point histology of fibrosis.}
}
@inproceedings{ISMRM2018_4736,
annote={ISMRM2018_4736},
pages={4736},
file={ISMRM2018_4736.pdf:ISMRM2018_4736.pdf:PDF},
title={{MRI} markers of liver related outcomes},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4736.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Chris R Bradley and Eleanor F Cox and Martin W James and Guru P Aithal and Neil Guha and Susan T Francis},
abstract={We used quantitative MR measures to assess changes in microstructure and haemodynamics in the liver and kidney of 60 patients with compensated cirrhosis (CC), 9 patients with decompensated cirrhosis (DC) and 40 healthy volunteers (HV). Liver T
1 and perfusion was significantly reduced and renal T
1 significantly increased with disease severity. In this prospective study, 1 in 6 CC patients have since had a Liver Related Outcome (LRO). These patients showed significant changes in baseline MR measures suggesting these MR measures in our multi-parametric MRI protocol can be used as a marker of LRO.}
}
@inproceedings{ISMRM2018_4737,
annote={ISMRM2018_4737},
pages={4737},
file={ISMRM2018_4737.pdf:ISMRM2018_4737.pdf:PDF},
title={Transducer-Free Hepatic Magnetic Resonance Elastography using Cardiac Wave Induction at 0.3ms Temporal Resolution},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4737.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Marian A Troelstra and Alessandro Polcaro and Omar Darwish and Jose de Arcos and Torben Schneider and Khaled Z Abd-Elmoniem and Ahmed M Gharib and Jurgen Runge and Ralph Sinkus},
abstract={Hepatic MRE is a promising non-invasive tool for diagnosing liver fibrosis. To facilitate clinical translation, we developed a method to eliminate the need for mechanical actuators for wave generation. Propagation of the transient cardiac shear waves within the liver caused by cardiac-valve closure can be imaged at a very high temporal resolution (0.3ms) using a 2D motion-sensitised pencil beam, with total data acquisition time fitting into four consecutive breath holds. These images were used to estimate liver stiffness, with a high temporal resolution allowing for reliable fitting to the space-time images and thus robust speed estimates.}
}
@inproceedings{ISMRM2018_4738,
annote={ISMRM2018_4738},
pages={4738},
file={ISMRM2018_4738.pdf:ISMRM2018_4738.pdf:PDF},
title={Comparison of different multi-fat peak models for the assessment of hepatic iron and fat},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4738.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Christian Kremser and Michaela Plaikner and Heinz Zoller and Werner Jaschke and Benjamin Henninger},
abstract={The evaluation of hepatic iron and fat by MR techniques is of increasing interest for clinical routine. The purpose of our study was to investigate the influence of different multi-peak fat models on the obtained R
2*, PDFF and goodness of fit values in patients with suspicion of diffuse liver disease. It is shown that the use of multi-peak fat spectrum modeling is highly recommended for accurate quantification of R
2* and PDFF . A 6-peak model resulted in the best goodness of fit. The use of a higher number of peaks seems to offer no additional advantage.}
}
@inproceedings{ISMRM2018_4739,
annote={ISMRM2018_4739},
pages={4739},
file={ISMRM2018_4739.pdf:ISMRM2018_4739.pdf:PDF},
title={Selective detection of liver fibrosis: Perfusion with hypercapnia challenge rather than T1 mapping.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4739.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={John J Connell and Thomas A Roberts and May Zaw-Thin and P Stephen Patrick and Rajiv Ramasawmy and Daniel J Stuckey and Manil D Chouhan and Daniel Antoine and Jack A Wells and Mark F Lythgoe and Tammy L Kalber},
abstract={Quantitative T1 mapping is starting to be used clinically as a measure of liver fibrosis, but is confounded by the presence of inflammation in the liver. Work presented here describes the development of a new quantitative MRI measure, “change in perfusion in response to CO
2 gas challenge”, in mice. This vasoactive challenge takes advantage of the pathological hallmarks of perivascular collagen seen in fibrosis, which is hypothesised to attenuate increases in tissue perfusion during hypercapnia.}
}
@inproceedings{ISMRM2018_4740,
annote={ISMRM2018_4740},
pages={4740},
file={ISMRM2018_4740.pdf:ISMRM2018_4740.pdf:PDF},
title={The preliminary study of staging liver fibrosis in patients with chronic hepatitis B using {MR} T1ρ},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4740.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Qing Li and Shuangshuang Xie and Hanxiong Qi and Zhizheng Zhuo and Yue Cheng and Wen Shen},
abstract={This study explored the value of MR T1ρ in patients with chronic hepatitis B. Twenty normal control subjects and forty-eight patients with chronic hepatitis B, including twenty-two patients who were confirmed by liver biopsy (F1/F2/F3=8/8/6) took the MR T1ρ scan. T1ρ value showed significant increase in patients with chronic hepatitis B compared with normal control subjects, significant correlation with liver fibrosis staging and higher sensitivity and specificity in identifying F1 to F3 of liver fibrosis. We conclude that MR T1ρ can provide reliable T1ρ values and can be used to assess liver fibrosis.}
}
@inproceedings{ISMRM2018_4741,
annote={ISMRM2018_4741},
pages={4741},
file={ISMRM2018_4741.pdf:ISMRM2018_4741.pdf:PDF},
title={Relevance of susceptibility weighted imaging with phase ({SWI}p) in Cholelithiasis},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4741.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jaladhar Neelavalli and Rakesh Kumar Gupta and Anandh Kilpattu Ramaniharan and Pradeep Kumar Gupta and Karthick Raj Rajendran and Rupsa Bhattacharjee},
abstract={Cholelithiasis, which is presence of stones in the biliary anatomy, is a common clinical condition with an incidence of up to 15\% worldwide. Magnetic resonance cholangiopancreatography (MRCP) is a standard MR technique used for diagnosing this condition. However, MRCP’s sensitivity is low when the stones are smaller than 5mm. These stones often contain trace amounts of minerals that are dia/paramagnetic. SWI is highly sensitive to susceptibility differences and hence we hypothesized that it may play a role in clinical evaluation of presence of gallstones. In this work we evaluated this hypothesis by imaging patients with Cholelithiasis using a modified SWI sequence.}
}
@inproceedings{ISMRM2018_4742,
annote={ISMRM2018_4742},
pages={4742},
file={ISMRM2018_4742.pdf:ISMRM2018_4742.pdf:PDF},
title={{GRASE} Revisited: Breath-hold Three-dimensional (3D) Magnetic Resonance Cholangiopancreatography using a Gradient and Spin Echo ({GRASE}) Technique at 3T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4742.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ju Gang Nam and Jeong Hee Yoon and Jeong Min Lee and Hyo-Jin Kang and Sang Min Lee and Johannes M. Peeters and Eunju Kim},
abstract={We evaluate the clinical feasibility and image quality of breath-hold (BH) three-dimensional (3D) MRCP using a gradient and spin-echo (GRASE) technique compared to the conventional 3D respiratory-triggered (RT)-MRCP using a turbo spin-echo (TSE) sequence at 3T. Sixty-six patients underwent both 3D RT-TSE-MRCP and 3D BH-GRASE-MRCP at 3T and three radiologists independently reviewed the images. The 3D BH-GRASE-MRCP had a significantly better image quality. In detail, 3D BH-GRASE-MRCP better depicted the common bile duct, cystic duct and bilateral 1st intrahepatic duct. The number of scans with nondiagnostic or poor image quality significantly decreased with 3D BH-GRASE-MRCP compared with 3D RT-TSE-MRCP.}
}
@inproceedings{ISMRM2018_4743,
annote={ISMRM2018_4743},
pages={4743},
file={ISMRM2018_4743.pdf:ISMRM2018_4743.pdf:PDF},
title={Comparison of Respiratory Motion Artifacts in T1-Weighted Liver Magnetic Resonance Imaging using End-expiration and End-inspiration Breath-Holds},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4743.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Kim Nhien Vu and Albert Tae-Hun Roh and Anshul Haldipur and Peter Lindholm and Andreas Markus Loening},
abstract={Respiratory motion artifact is a common pitfall in MRI of the liver and no standard of practice currently exists for breath-hold imaging techniques. This retrospective observational study compared image quality between end-inspiration and end-expiration breath-holding techniques. Precontrast T1-weighted 3D spoiled gradient recalled echo imaging of the liver obtained using the two techniques were compared in 50 consecutive subjects, along with postcontrast sequences in a subset of 47. Three radiologists performed blinded evaluations of respiratory motion in the sequences. Breath-holding technique at end-expiration was significantly better at reducing respiratory motion artifacts, yielding fewer images of nondiagnostic quality than end-inspiration breath-holding technique.}
}
@inproceedings{ISMRM2018_4744,
annote={ISMRM2018_4744},
pages={4744},
file={ISMRM2018_4744.pdf:ISMRM2018_4744.pdf:PDF},
title={4D Flow {MRI}: A Preliminary Analysis of Changes in Arterial Flow During Liver Embolization In Swine},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4744.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Carson Anthony Hoffman and Ece Meram and Paul Laeseke and Oliver Wieben},
abstract={Transarterial embolization is a common treatment for liver tumors. Currently, radiographic techniques are used clinically to provide anatomical and qualitative hemodynamic information in assessment and treatment of liver tumors. The addition of 4D Flow MRI has the potential to provide functional information about the hemodynamic changes occurring pre, during and post treatment. We completed a feasibility study in a swine, in which clear flow changes were seen in the hepatic vascular system. The additional information provided by 4D Flow MRI has potential to improve the care of cancer patients.}
}
@inproceedings{ISMRM2018_4745,
annote={ISMRM2018_4745},
pages={4745},
file={ISMRM2018_4745.pdf:ISMRM2018_4745.pdf:PDF},
title={Incorporating Motion-Sorting Technique into Keyhole and k-t {GROWL} Compound System for Rapid Golden-angle Liver {DCE} Imaging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4745.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Zhifeng Chen and Liyi Kang and Ling Xia and Xia Kong and Allan Jin and Zhongbiao Xu and Yaohui Wang and Feng Liu},
abstract={Liver DCE imaging plays an increasingly important role in the diagnosis of liver diseases, including hepatic cirrhosis, hepatocellular carcinoma, etc. Motion is an inevitable problem in liver imaging, which often leads to motion artifacts and blurring on image details. We propose to incorporate motion-sorting technique into parallel imaging GROWL and Keyhole compound system for golden-angle radial dynamic contrast-enhanced MRI. The experimental results demonstrated that the proposed scheme can generate better image quality than non-motion-sorting techniques. Compared to the tested motion-sorting techniques, similar image quality can be offered with greatly reduced computational cost.}
}
@inproceedings{ISMRM2018_4746,
annote={ISMRM2018_4746},
pages={4746},
file={ISMRM2018_4746.pdf:ISMRM2018_4746.pdf:PDF},
title={Evaluation of Fat-Only Self Gated Signal for Respiratory Motion Detection and Compensation in the Liver},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4746.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Thomas Martin and Tess Armstrong and Alibek Danyalov and Eunice Lee and Ely Felker and James Sayre and Steven Raman and Holden Wu and Kyunghyun Sung},
abstract={A dual-echo 3D golden angle radial gradient echo sequence can be used for generating a fat-only self-gated signal for respiratory motion detection. We have demonstrated that respiratory motion extraction and compensation in the liver can be achieved using fat-only self-navigated signal with minimal error in the fat-water separation (< 15\%). Using this technique has implications of a more robust motion correction for liver DCE-MRI due to its inherent separation between respiratory motion signal and contrast uptake.}
}
@inproceedings{ISMRM2018_4747,
annote={ISMRM2018_4747},
pages={4747},
file={ISMRM2018_4747.pdf:ISMRM2018_4747.pdf:PDF},
title={Gd-{EOB}-{DTPA}-Enhanced {MRI} for Assessment of Liver Function: Comparison between Signal Intensity and T1 Relaxation Time-Based Indices},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4747.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Xueqin ZHANG and Jian LU and Jifeng JIANG and Weibo CHEN},
abstract={The purpose of this study was to compare the ability of Gd-EOB-DTPA-enhanced signal intensity (SI) and T1 relaxation time-based indices for evaluation of liver function. We used Gd-EOB-DTPA-enhanced MRI and Look-Locker sequences to acquire conventional MRI and T1mapping images. The SI values of the liver, paravertebral muscle, T1 relaxation times of the liver before Gd-EOB-DTPA administration and in HBP were measured, the relative enhancement of the liver, increase rates of liver-to-muscle ratio, reduction rates of T1 relaxation time and ΔR1 were calculated, our study showed that the indices derived from T1 relaxation time were superior to SI-based indices.
}
}
@inproceedings{ISMRM2018_4748,
annote={ISMRM2018_4748},
pages={4748},
file={ISMRM2018_4748.pdf:ISMRM2018_4748.pdf:PDF},
title={Respiratory motion-corrected simultaneous myocardial viability {PET} and coronary {MR} angiography: initial clinical validation},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4748.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Camila Munoz and Karl P Kunze and Radhouene Neji and Christoph Rischpler and René M Botnar and Stephan G Nekolla and Claudia Prieto},
abstract={Cardiac PET-MR imaging has shown promising results for the comprehensive assessment of coronary artery disease. Here we present an initial clinical validation of a recently demonstrated respiratory motion-corrected PET-MR framework in patients with chronic total occlusion. Simultaneous visualization of the coronary lumen by Coronary MR Angiography (CMRA) and myocardial viability by 18F-FDG PET was compared against X-ray angiography and LGE-MRI. We demonstrate that the proposed framework produces diagnostic images in both modalities in a short and time-efficient examination of ~12 minutes. Motion correction improved visible length and sharpness of the coronary arteries by CMRA and delineation of the myocardium and noise reduction by 18F-FDG PET, resulting in good agreement with X-ray angiography and LGE-MRI.}
}
@inproceedings{ISMRM2018_4749,
annote={ISMRM2018_4749},
pages={4749},
file={ISMRM2018_4749.pdf:ISMRM2018_4749.pdf:PDF},
title={Non-invasive {MR}-based blood oximetry via multi-parametric, non-linear estimation: initial multi-center experience in adult and pediatric patients},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4749.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Juliet Varghese and Lajja Desai and Rizwan Ahmad and Lee C Potter and Ning Jin and Cynthia K Rigsby and Paul Tannous and Aimee K Armstrong and Michael Markl and Kan N Hor and Subha Raman and Orlando P Simonetti},
abstract={Non-invasive estimation of blood oxygen (O2) saturation by magnetic resonance (MR) imaging would be useful in evaluating shunt severity in congenital heart disease and oxygen delivery and consumption energetics in heart failure and pulmonary hypertension. A T2-based, non-linear, multi-parameter method has been developed to non-invasively determine O2 saturation in the heart and great vessels. In this multi-center study, the feasibility and accuracy of the technique is evaluated against gold-standard catheterization measurements in the cardiac chambers and vessels in a preliminary cohort of adult and pediatric patients with cardiovascular disease.}
}
@inproceedings{ISMRM2018_4750,
annote={ISMRM2018_4750},
pages={4750},
file={ISMRM2018_4750.pdf:ISMRM2018_4750.pdf:PDF},
title={Imaging inflammation following {MI} using hyperpolarized pyruvate and 3D Spectral-Spatial {EPI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4750.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jack J J J Miller and Andrew J Lewis and Carolyn A Carr and Oliver Rider and Stefan Neubauer and Damian J Tyler},
abstract={Current clinical imaging techniques offer only limited assessment of innate immune cell driven inflammation, which is an emerging therapeutic target in myocardial infarction. However, macrophages have a defined metabolic phenotype and are highly glycolytic when activated following injury. Here we show that hyperpolarized [1-$^{13}$C]pyruvate imaging specifically detects this phenotype, which is altered by pharmacological blockade that modulates monocyte/macrophage inflammatory function both in vitro and in vivo. We conclude that cardiac hyperpolarized [1-$^{13}$C]lactate several days post insult reflects immunology and not necessarily ischaemia.}
}
@inproceedings{ISMRM2018_4751,
annote={ISMRM2018_4751},
pages={4751},
file={ISMRM2018_4751.pdf:ISMRM2018_4751.pdf:PDF},
title={Simultaneous 3D whole-heart bright-blood and black blood imaging for cardiovascular anatomy and wall assessment with interleaved T2prep-{IR}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4751.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Giorgia Milotta and Giulia Ginami and Radhouene Neji and Claudia Prieto and René Botnar},
abstract={Visualization of cardiovascular anatomy is important for diagnosis, risk stratification and planning of interventional procedures both in patients with congenital and non-congenital heart disease. This study proposes a novel free-breathing 3D whole-heart flow-independent approach for bright-blood visualization of coronary lumen and cardiac structures and for black-blood delineation of aortic, atrial and coronary artery walls. The use of image-based navigation and non-rigid respiratory motion correction allows for 100\% scan efficiency, predictable scan time and improved image sharpness.}
}
@inproceedings{ISMRM2018_4752,
annote={ISMRM2018_4752},
pages={4752},
file={ISMRM2018_4752.pdf:ISMRM2018_4752.pdf:PDF},
title={Accelerated Coronary 4D-Flow {MRI}: towards noninvasive functional assessment of stable coronary artery disease},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4752.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Zixin Deng and Michael Loecher and Anthony Christodoulou and Christopher Nguyen and Zhengwei Zhou and Jaime Shaw and Yibin Xie and Xiaoming Bi and Zhaoyang Fan and Daniel Ennis and Debiao Li},
abstract={In patients with suspected coronary artery disease (CAD), invasive catheterization is commonly used to determine the need for coronary revascularization. However, recent studies have shown that >50\% of patients who undergo invasive catheterization have non-significant coronary lesions, hence the procedure was unnecessary. Recent work using 4D-Flow and the Navier-Stokes equations has shown promise for the noninvasive assessment of CAD,but still requires long scan times. This work explored coronary 4D-Flow using a stack-of-stars acquisition and compressed sensing to achieve 2-3x acceleration. The goal was to develop a more clinically feasible noninvasive pressure gradient measurement method for the assessment of CAD.}
}
@inproceedings{ISMRM2018_4753,
annote={ISMRM2018_4753},
pages={4753},
file={ISMRM2018_4753.pdf:ISMRM2018_4753.pdf:PDF},
title={Surveillance of abdominal aortic aneurysm using accelerated 3D non-contrast black-blood {MRI} with compressed sensing ({CS}-{DANTE}-{SPACE})},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4753.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Chengcheng Zhu and Lizhen Cao and Zhaoying Wen and Sinyeob Ahn and Esther Raithel and Christoph Forman and Michael D Hope and David Saloner},
abstract={Although 3D non-contrast high-resolution black-blood MRI (DANTE-SPACE) is a promising tool for the surveillance of abdominal aortic aneurysm (AAA), it requires lengthy scans (~7 minutes). We implemented a compressed sensing method (CS-DANTE-SPACE) to reduce the scan time by 41\% (to ~4 minutes) and tested its feasibility in 20 AAA patients undergoing routine follow-up. We found CS-DANTE-SPACE achieved accurate diameter/area measurements and intraluminal thrombus (ILT) identification and provided better contrast and vessel sharpness. CS-DANTE-SPACE is a promising tool for AAA surveillance in the clinical setting.}
}
@inproceedings{ISMRM2018_4754,
annote={ISMRM2018_4754},
pages={4754},
file={ISMRM2018_4754.pdf:ISMRM2018_4754.pdf:PDF},
title={Imaging lower extremity vein thrombosis using a 3D {FSE} with novel modulated flip angle scheme and random k-space undersampling},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4754.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ling Zhang and Jie Zhang and Rui Li and Shuo Chen and Chaohong Wang and Nan-Jie Gong and Guobin Li and Ruchen Peng},
abstract={Accurate detection of lower extremity vein thrombosis (LEVT) and assessment of its stage are crucial for treatment decision-making. Challenges such as long scan time and requirement for dark-blood, exist in T2-weighted MR imaging of LEVT. A 3D FSE with novel modulated refocusing flip angles and random undersampling is introduced and applied to imaging of LEVT.}
}
@inproceedings{ISMRM2018_4755,
annote={ISMRM2018_4755},
pages={4755},
file={ISMRM2018_4755.pdf:ISMRM2018_4755.pdf:PDF},
title={Late gadolinium enhancement by cardiovascular magnetic resonance, combined with right ventricle ejection fraction, for assessing the severity and predicting the prognosis of chronic thromboembolic pulmonary hypertension},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4755.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ming-xi Liu and Juan-ni Gong and Xiao-juan Guo and Zhan-hong Ma and Tao Jiang and Jing An and Lu Liang and Yuan-hua Yang and Tu-guang Kuang},
abstract={The aim of this study was to assess the severity and predict the prognosis of chronic thromboembolic pulmonary hypertension (CTEPH) using cardiovascular magnetic resonance with late gadolinium enhancement (LGE) combined with the right ventricle ejection fraction. Based on right heart catheterization, the percentages of the myocardial fibrosis volume (pFV>7.00\%) and right ventricle ejection fraction (RVEF<34.34\%) cut-off values were determined to assess the severity and predict the prognosis of 30 patients with CTEPH. The pFV and LGE are complementary to the RVEF for assessing the severity of the condition and can be a strong prognostic factor in patients with CTEPH.}
}
@inproceedings{ISMRM2018_4756,
annote={ISMRM2018_4756},
pages={4756},
file={ISMRM2018_4756.pdf:ISMRM2018_4756.pdf:PDF},
title={Volumetric black-blood fast spin echo with variable refocusing pulses for the visualization of whole-heart and great vessels},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4756.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Markus Henningsson and Gerald Greil and Riad Abou Zahr and Animesh Tandon and Barbara Burkhardt and Tarique Hussain},
abstract={We describe the use of black-blood 3D fast spin echo with variable refocusing flip angles for whole-heart imaging. The technique allows efficient, volumetric high-resolution imaging of the heart and great vessels and improves aortic vessel wall delineation compared to conventional 2D double-inversion recovery. It also provides complementary diagnostic information to 3D bright-blood bSSFP, particularly for the visualization of pulmonary veins. This was demonstrated in a study of 8 patients with congenital heart disease.}
}
@inproceedings{ISMRM2018_4757,
annote={ISMRM2018_4757},
pages={4757},
file={ISMRM2018_4757.pdf:ISMRM2018_4757.pdf:PDF},
title={Significant Improvement of Blood Suppression in Cardiac Dark-Blood T1-{TSE} Imaging By Combining the T2-{TSE} Blood Nulling Strategy with Dummy Acquisitions for Myocardial T1-Weighting – A Comparison of Conventional and Novel {TSE} Techniques for Blood Signal Suppression and Overall Image Quality at 3T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4757.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Wolfgang G Rehwald and Louis Klem and Stephen Darty and Nestor Mena and George Gamoneda and Raymond J Kim},
abstract={Cardiac dark-blood (DB) T1-turbo-spin echo (TSE) imaging frequently suffers from poor blood suppression due to its short effective TR required for good myocardial T1-weighting. We present a novel DB T1-TSE sequence that simultaneously applies a long effective TR as in T2-TSE to blood and a short effective TR as in conventional T1-TSE to myocardium, by means of dummy readouts. We ran conventional T1-TSE, T2-TSE and novel T1-TSE sequences in 53 patients and scored the images for DB performance and overall image quality. Quality and blood suppression were drastically improved by novel T1-TSE.}
}
@inproceedings{ISMRM2018_4758,
annote={ISMRM2018_4758},
pages={4758},
file={ISMRM2018_4758.pdf:ISMRM2018_4758.pdf:PDF},
title={{MRI}-Based Stress Analyses of Abdominal Aortic Aneurysms With Resolved Intraluminal Thrombus Heterogeneity},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4758.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Joseph R Leach and Chengcheng Zhu and David Saloner and Michael D Hope},
abstract={Computational stress analyses of abdominal aortic aneurysms (AAA) are of great interest for individual aneurysm rupture risk assessment. The vast majority of patient-specific stress analyses are based on features seen at computed tomography, which is incapable of resolving material heterogeneity within intraluminal thrombus. Using T1-weighted black blood MRI, we imaged and explicitly modeled MRI-discerned intraluminal thrombus heterogeneity in multiple AAA stress analyses. Results demonstrate a limited effect of thrombus heterogeneity on the predicted vessel wall stresses, but suggest a possible role for MRI to inform thrombus material stiffness assignment in stress computations.}
}
@inproceedings{ISMRM2018_4759,
annote={ISMRM2018_4759},
pages={4759},
file={ISMRM2018_4759.pdf:ISMRM2018_4759.pdf:PDF},
title={Proton magnetic resonance spectroscopy to assess lipid content in cardiac amyloidosis},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4759.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Mareike Gastl and Sophie Peereboom and Alexander Gotschy and Maximilian Fuetterer and Constantin von Deuster and Florian Bönner and Malte Kelm and Andreas Flammer and Robert Manka and Sebastian Kozerke},
abstract={Amyloidosis is a multisystemic disorder frequently affecting the heart and causing heart failure. In this work, MR imaging and spectroscopy was implemented and applied to characterize myocardial structure and function as well as changes in fatty acid storage of the heart. We found that myocardial triglyceride-to-water ratio was significantly decreased in amyloidosis compared to age-and body mass index-matched controls. Myocardial triglyceride-to-water ratio showed a negative tendency with increasing markers of heart failure. It is concluded that proton spectroscopy may provide an additional biomarker to gauge progression of cardiac amyloidosis.}
}
@inproceedings{ISMRM2018_4760,
annote={ISMRM2018_4760},
pages={4760},
file={ISMRM2018_4760.pdf:ISMRM2018_4760.pdf:PDF},
title={Practical implementation of {SMS} b{SSFP} in the Heart},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4760.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Vanessa Landes and Terrance Jao and Krishna Nayak},
abstract={Cardiac MRI frequently relies on balanced stead-state free precession (bSSFP) for its beneficial contrast and SNR efficiency. Simultaneous multi-slice (SMS) imaging, specifically blipped controlled aliasing in parallel imaging, faces two major challenges with cardiac bSSFP: 1) artifacts from non-uniform signal in the through-slice direction and 2) spuriously excited side-lobes from imperfect multi-band excitation. We carefully evaluate both challenges using simulations and phantom experiments and demonstrate practical SMS bSSFP imaging with 3-slice coverage (apical, mid and basal short axis slices) at 3 Tesla, with good image quality in both transient-state and steady-state.}
}
@inproceedings{ISMRM2018_4761,
annote={ISMRM2018_4761},
pages={4761},
file={ISMRM2018_4761.pdf:ISMRM2018_4761.pdf:PDF},
title={Reconstruction of the 12-lead {ECG} using a novel {MR}-compatible {ECG} sensor network},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4761.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jesus E Dos Reis and Paul Soullié and Grégory Petitmangin and Freddy Odille and Jacques Felblinger},
abstract={Currently patient monitoring and sequence triggering during MR imaging are achieved using a low bandwidth ECG of 1Hz-60 Hz. Such devices provide a limited number of ECG leads and thus do not provide the same diagnostic information as the standard 12-lead ECG. In this work we developed a high-bandwidth MR-compatible ECG sensor (0.05Hz – 150 Hz) that integrates real-time signal processing for ECG denoising. Several individual sensors are combined to reconstruct a 12-lead ECG during MR imaging. The system was tested on a volunteer at 1.5T and could be used during MR-guided intervention or for inverse ECG imaging.}
}
@inproceedings{ISMRM2018_4762,
annote={ISMRM2018_4762},
pages={4762},
file={ISMRM2018_4762.pdf:ISMRM2018_4762.pdf:PDF},
title={A Normalized Segmented T2{STIR}-b{SSFP} Technique for High Resolution Edema Imaging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4762.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Lixian Zou and Yanjie Zhu and Dong Liang and Xin Liu},
abstract={High resolution edema image is highly desired for reducing particle volume effect (PVE) on thin myocardium. In this work, we proposed a normalized segmented T
2STIR-bSSFP to improve base resolution from 192 to 320 in edema imaging as well as maintain high contrast of edema to myocardium. The results show that the proposed method can reduce PVE on thin myocardium and makes edema imaging for the right ventricle myocardium being possible.}
}
@inproceedings{ISMRM2018_4763,
annote={ISMRM2018_4763},
pages={4763},
file={ISMRM2018_4763.pdf:ISMRM2018_4763.pdf:PDF},
title={5D cardiac {MRI} on mouse models : preliminary results},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4763.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Julia Labrune and Aurélien J Trotier and Emeline J Ribot and Sylvain Miraux},
abstract={Until now, the data acquired during breathing period are not used to obtain 4D cardiac images on mouse models. Consequently, the purpose of the work presented here is to evaluate the impact of breathing on the movement of the mouse's heart and to develop a method for reconstructing the cardiac self-gating signal during respiration. Finally, preliminary results of 5D image reconstruction (3D images during the heart rate and according to respiratory movement) will be shown in mice.}
}
@inproceedings{ISMRM2018_4764,
annote={ISMRM2018_4764},
pages={4764},
file={ISMRM2018_4764.pdf:ISMRM2018_4764.pdf:PDF},
title={Tracking of {PLGA}-{PFCE}-labeled Cardiac Stem Cells Seeded on Novel Biodegradable Poly(3-hydroxyoctanoate) Scaffolds Implanted on the Murine Myocardium using 1H and 19F {MRI}/{MRS}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4764.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Chris Constantinides and Pooja Basnett and Barbara Lukasiewicz and Ricardo Carnicer Hijazo and Mangala Srinivas and Carolyn Carr and Ipsita Roy},
abstract={Controlled administration of cardiac progenitor stem cells (CPCs) and their visualization and tracking and release, still present tremendous challenges in cellular/tissue therapy, yet fundamental and necessary tasks towards a therapeutically successful approach. In this work, we propose the synthesis and use of novel, functional biodegradable, biocompatible, Polyhydroxyalkanoate (PHA) and Poly-caprolactone (PCL) polymer blend scaffolds to: a) achieve controlled delivery of CPCs, thereby prolonging the viability and maximizing retention of delivered stem cells to the murine myocardium and b) the use of 19F MRI/MRS to noninvasively detect and monitor the cells temporally.}
}
@inproceedings{ISMRM2018_4765,
annote={ISMRM2018_4765},
pages={4765},
file={ISMRM2018_4765.pdf:ISMRM2018_4765.pdf:PDF},
title={T1-mapping Cardiac-Manganese Enhanced {MRI}: Assessment of Calcium Homeostasis and Ischemic Injury in Mice},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4765.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Nur Hayati Jasmin and Laurence H Jackson and Thomas A Roberts and Valerie Taylor and Mark F Lythgoe and Daniel J Stuckey},
abstract={Intracellular MR contrast agents can provide essential information on cell viability. Manganese (Mn
2+) is an efficient intracellular MR contrast agent. As an analogue of Calcium, Mn
2+-induced changes in T1 and can be used as an indicator of the
rate of Ca
2+ influx into cardiomyocytes in vivo and could provide additional information to that routinely acquired using late Gd-enhanced MRI. By preloaded the myocardium with Mn
2+ prior to coronary occlusion, we showed that MEMRI T1-mapping allows sensitive in vivo detection of subtle changes and accumulation of Mn
2+ in viable myocytes in the early phase of myocardial injury.}
}
@inproceedings{ISMRM2018_4766,
annote={ISMRM2018_4766},
pages={4766},
file={ISMRM2018_4766.pdf:ISMRM2018_4766.pdf:PDF},
title={Detection of early phase of deep vein thrombosis with diffusion-weighted magnetic resonance imaging.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4766.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yasuyoshi Kuroiwa and Atsushi Yamashita and Toshihiro Gi and Yuko Mizutani and Taketoshi Asanuma and Tosiaki Miyati and Takuroh Imamura and Yujiro Asada},
abstract={To detect and characterize deep vein thrombus (DVT), we performed diffusion weighted magnetic resonance imaging (MRI) in 8 patients and a rabbit model of DVT. All patients were detected DVT as high or mixed high and iso signal intensity on diffusion weighted MRI. The rabbit venous thrombi showed high signal intensity on diffusion weighted MRI at 4 hours, or mixed iso to high and low signal intensity at 1, 2, 3 weeks. The signal intensity was positively correlated with erythrocyte contents. Diffusion weighted MRI can detect DVT and high signal intensity on the sequence may reflect early phase of DVT.}
}
@inproceedings{ISMRM2018_4767,
annote={ISMRM2018_4767},
pages={4767},
file={ISMRM2018_4767.pdf:ISMRM2018_4767.pdf:PDF},
title={Feasibility of {EPI} for cardiac diffusion at 7T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4767.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Elizabeth M Tunnicliffe and Jesper L R Andersson and Aaron T Hess and Matthew D Robson},
abstract={Cardiac diffusion imaging promises new insights into myocardial microstructure and integrity, but is an SNR-starved technique. Imaging at 7T may enable fewer signal averages, but most cardiac diffusion implementations use an EPI readout, which suffers from spatial distortion at higher field strengths. In this work we demonstrate distortion-corrected, EPI-based, cardiac diffusion tensor imaging at 7T using images acquired with forward and reversed phase encoding directions. We find myocardial ADC and FA consistent with previously published 3T data and that, with this acquisition protocol, distortion correction does not lead to statistically significant changes in ADC and FA.}
}
@inproceedings{ISMRM2018_4768,
annote={ISMRM2018_4768},
pages={4768},
file={ISMRM2018_4768.pdf:ISMRM2018_4768.pdf:PDF},
title={Assessing the optimal preparation strategy to minimize variability of pyruvate dehydrogenase flux measurements with hyperpolarized [1-13C]pyruvate {MRS} in control and type 2 diabetic rats},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4768.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Kerstin N Timm and Andrew Apps and Vicky Ball and Jack J Miller and Michael S Dodd and Damian J Tyler},
abstract={Hyperpolarized [1-
13C] pyruvate MRS measures pyruvate dehydrogenase (PDH) flux in vivo in the heart through
13C-label incorporation into bicarbonate. Substrate availability modulates PDH flux; clinical protocols attempt to standardize flux with oral glucose loading prior to scanning, while rodents in preclinical studies are scanned in the fed state. We set out to establish whether feeding or glucose loading leads to more reproducible measurements of PDH flux in control rats and found a variability of 45.1\% in fed and 50.0\% in glucose-loaded animals. Furthermore, glucose loading did not alter the low PDH flux seen in type II diabetic rats.}
}
@inproceedings{ISMRM2018_4769,
annote={ISMRM2018_4769},
pages={4769},
file={ISMRM2018_4769.pdf:ISMRM2018_4769.pdf:PDF},
title={Quantitative modeling and detection of flux through pyruvate dehydrogenase in human myocardium},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4769.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jeffry R. Alger and Jian-xiong Wang and Jeannie Baxter and Jeff Liticker and Crystal Harrison and Vlad Zaha and Albert Chen and Salvador Pena and Lucy Christie and Richard Martin and Kelley Derner and Carol Parcel and A. Dean Sherry and Craig R. Malloy},
abstract={Flux through pyruvate dehydrogenase, a key regulatory enzyme, may be detected in human myocardium by hyperpolarization (HP) technology. A previously-validated model for quantitation of pyruvate metabolism in isolated hearts was extended to human myocardium. HP [
13C]bicarbonate and HP[1-
13C]lactate were detected from heart muscle after injection of ~0.43 mL/kg of 250mM HP[1-
13C]pyruvate in four healthy subjects. All subjects tolerated the procedure well. Kinetic modeling yielded a rate constant for oxidation of pyruvate to bicarbonate of 0.005 sec
-1, lower than that reported for isolated rodent hearts. Assessment of PDH flux in human myocardium is feasible with hyperpolarization technology.}
}
@inproceedings{ISMRM2018_4770,
annote={ISMRM2018_4770},
pages={4770},
file={ISMRM2018_4770.pdf:ISMRM2018_4770.pdf:PDF},
title={Fast multi-slice myocardial T1 mapping ({FAST}1)},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4770.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Li Huang and Radhouene Neji and Reza Razavi and Sébastien Roujol},
abstract={Myocardial T1 mapping shows promise for the detection of cardiomyopathy. The widely-used inversion recovery based approaches, such as MOdified Look-Locker Inversion recovery (MOLLI), can only generate a single T1 map from one breathhold scan. In this study, we developed a novel FASt multi-slice myocardial T1 mapping (FAST1) approach in a single breathhold using slice-selective inversion recovery, two inversion times per slice and an advanced reconstruction approach. This technique was evaluated in a phantom as well as in healthy volunteers and provided similar repeatability, limited precision penalty and increased spatial coverage compared to MOLLI.}
}
@inproceedings{ISMRM2018_4771,
annote={ISMRM2018_4771},
pages={4771},
file={ISMRM2018_4771.pdf:ISMRM2018_4771.pdf:PDF},
title={A New Myocardial T1-Mapping Technique: {MOSHA}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4771.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Majid Sohani and Sébastien Roujol and Andrew J. Powell and Andreas Maier and Mehdi H. Moghari},
abstract={To develop an accurate and precise T1-mapping sequence, we combined the modified Look-Locker inversion recovery (MOLLI) and saturation recovery single-shot acquisition (SASHA) sequences--MOSHA. Compared to SASHA, MOSHA had similar accuracy and higher precision. Compared to MOLLI, MOSHA had better accuracy and lower precision.
}
}
@inproceedings{ISMRM2018_4772,
annote={ISMRM2018_4772},
pages={4772},
file={ISMRM2018_4772.pdf:ISMRM2018_4772.pdf:PDF},
title={Combined fractal and connected component analysis for characterization of cardiac fibrosis distribution in end stage renal disease patients on routine hemodialysis},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4772.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Zeynep Ali and Bonnie Lam and Moriel Vandsburger},
abstract={A magnetization transfer based MRI technique for measurement of cardiac fibrosis was applied to 34 end stage renal disease patients on routine hemodialysis and 19 controls. Short axis maps of changes in tissue magnetization transfer properties were combined to create 3D domains in which anatomical connectivity of voxels in the myocardium was linearized. Connected component analysis was used to isolate distinct spatially connected sub-regions of myocardium and fractal analysis of magnetization transfer changes was applied to the whole myocardium as well as these sub-regions. The measured fractal dimensions show tissue-level structural differences between the different tissue types and patient populations.}
}
@inproceedings{ISMRM2018_4773,
annote={ISMRM2018_4773},
pages={4773},
file={ISMRM2018_4773.pdf:ISMRM2018_4773.pdf:PDF},
title={Towards automatic analysis of 4D Flow {MRI}: Automatic cardiac segmentation},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4773.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Mariana Bustamante and Vikas Gupta and Daniel Forsberg and Carl-Johan Carlhäll and Jan Engvall and Tino Ebbers},
abstract={One of the most important post-processing steps in the analysis of cardiac MR images is the segmentation of the blood pool, usually relying on manual delineation of the cardiac anatomy by an expert observer. Obtaining high quality segmentations of 4D Flow MR images acquired without the use of blood pool agents is especially challenging due to the low contrast between the blood and the myocardium present in these images. We propose an automatic multi-atlas segmentation technique that generates four-dimensional segmentations of the cardiac chambers and great thoracic vessels in 4D Flow MR images.}
}
@inproceedings{ISMRM2018_4774,
annote={ISMRM2018_4774},
pages={4774},
file={ISMRM2018_4774.pdf:ISMRM2018_4774.pdf:PDF},
title={A Simple Method for Post-Processing Correction of 3D Radial Trajectory Imperfections in 5D Cardiac {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4774.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Lorenzo Di Sopra and Jérôme Yerly and John Heerfordt and Davide Piccini and Matthias Stuber},
abstract={Three-dimensional radial trajectories have shown important benefits for multidimensional MR imaging of the heart. However, the performance of radial scanning approaches is sensitive even to small trajectory imperfections, which can induce significant artifacts in the reconstructed images. Here, we implemented a simple and flexible post-processing technique for trajectory inaccuracy artifact compensation that does not require any pre-scan calibration or pulse sequence modification. The technique proved effective when applied to in silico and in vitro phantom datasets and preliminarily results suggest good feasibility in vivo for fully self-gated and motion-resolved 5D cardiac imaging.}
}
@inproceedings{ISMRM2018_4775,
annote={ISMRM2018_4775},
pages={4775},
file={ISMRM2018_4775.pdf:ISMRM2018_4775.pdf:PDF},
title={Robust tissue tracking from cardiac cine {MRI} with deep-learning-based fully automatic myocardium segmentation},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4775.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Xue Feng and Nicholas J Tustison and Kun Qing and Christopher M Kramer and Craig H Meyer},
abstract={Tissue tracking post processing from cardiac cine MRI can be used to calculate myocardial deformation parameters without additional scans. One major drawback of the processing is reduced reliability due to interference from blood and trabecular muscle signals and varying image contrast. Manual segmentation of LV myocardium can improve the robustness but is time consuming. We developed a deep convolutional neural network to automatically segment myocardium and used symmetric deformable registration to obtain the tracking information from the resulting binary masks. The segmentation and tracking worked reliably well, resulting in accurate pixel movement trajectories.}
}
@inproceedings{ISMRM2018_4776,
annote={ISMRM2018_4776},
pages={4776},
file={ISMRM2018_4776.pdf:ISMRM2018_4776.pdf:PDF},
title={Strain elastography using a feature- tracking of cine cardiac magnetic resonance imaging: assessment of liver fibrosis in Fontan patients and tetralogy of Fallot},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4776.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ryoko Ohashi and Michinobu Nagao and Umiko Ishizaki and Yuka Matsuo and Kenji Fukushima and Yasuhiro Goto and Yumi Shiina and Kei Inai and Seiko Simizu and Yuichiro Sano and Masami Yoneyama and Shuji Sakai},
abstract={We propose a new strain elastography to quantify hepatic fibrosis using feature tracking method of cardiac cine MRI and investigate the strain elasticity in long-term post-operative patients after Fontan and intracardiac repair (ICR) for tetralogy of Fallot (TOF). The strain elasticity was lower for Fontan patients than that for TOF patients and controls, suggesting that liver fibrosis progresses after Fontan operation. The strain elastography using feature tracking method of cardiac cine MRI is a noninvasive new method for prediction of liver fibrosis.}
}
@inproceedings{ISMRM2018_4777,
annote={ISMRM2018_4777},
pages={4777},
file={ISMRM2018_4777.pdf:ISMRM2018_4777.pdf:PDF},
title={Automatic Quantification of Left Ventricular Non-compaction using Fractal Dimension and Parametric Ratio as Geometric Markers: Numerical Simulation and Clinical Evaluation},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4777.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Amol S. Pednekar and Carter Chu and Tobias Schlingmann and Zili David Chu and Siddharth Jadhav and Cory Noel and Prakash Masand},
abstract={BSSFP distinguishes the non-compacted trabeculation (NC) from compacted myocardium (C), however the current diagnostic criterion (NC/C>2.3) for left ventricular non-compaction (LVNC) suffers from subjective variability and tends to over-diagnose, especially in pediatric patients where LV trabeculation varies on a continuous spectrum. Numerical simulations estimate exponential relationship between fractal dimension (FD) and perimetric ratio (PR) with 11 times higher dynamic range for PR for the observed FD range in 30 LVNC positive and 20 negative controls. Both FD and PR indices distinguish LVNC positive from negative (p<0.0001), while the PR and FD*PR provided 6 and 11 times higher dynamic ranges respectively.}
}
@inproceedings{ISMRM2018_4778,
annote={ISMRM2018_4778},
pages={4778},
file={ISMRM2018_4778.pdf:ISMRM2018_4778.pdf:PDF},
title={{CMRD}iffTools: A Processing and Analysis Tool for Cardiac Diffusion {MR} images},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4778.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={William A. Romero R. and Magalie Viallon and Martijn Froeling and Christian Stoeck and Sebastian Kozerke and Elizabeth Tunnicliffe and Andrew Scott and Pedro Ferreira and Eric Aliotta and Daniel Ennis and Kévin Moulin and Pierre Croisille},
abstract={CMRDiffTools is an OsiriX/Horos plug-in for simplifying and streamlining the processing and analysis tasks of Cardiac Diffusion MR images. This tool includes state-of-the-art methods in image processing of diffusion weighted images, assembled in suitable workflows to be executed in a single pipeline. The CMRDiffTools plug-in empowers the user with interactive data exploration and visualization of specific cardiac fiber metrics such as helix, transverse and sheet angle.}
}
@inproceedings{ISMRM2018_4779,
annote={ISMRM2018_4779},
pages={4779},
file={ISMRM2018_4779.pdf:ISMRM2018_4779.pdf:PDF},
title={Methodology for Non-Diseased Myocardium Part Segmentation of Delayed Enhancement 3D {MRI} by Using Watershed and Shape Priors},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4779.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Dominika Kruk and Arnaud Boucher and Alain Lalande and Alexandre Cochet and Tadeusz Sliwa},
abstract={Previous approaches on left ventricle segmentation from DE-MRI have focused on the extraction of myocardium or just diseased region in short axis orientation. However these studies are not well suited for the segmentation of non-diseased myocardium region on DE-MRI. This paper presents a novel semi-automatic segmentation method of non-diseased myocardium region segmentation on diseased patient heart from DE-MRI based on watershed algorithm with shape priors application. To assess the results segmented images were compared with gold standard images performed by an experienced user. Novel solution for DE-MRI segmentation has been proposed, which brought promising results of measured parameters.}
}
@inproceedings{ISMRM2018_4780,
annote={ISMRM2018_4780},
pages={4780},
file={ISMRM2018_4780.pdf:ISMRM2018_4780.pdf:PDF},
title={Automatic labeling of cerebral vessels in time-resolved contrast enhanced angiography},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4780.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Oren Geri and Shelly I. Shiran and Dafna Ben Bashat},
abstract={This study proposes a fully automatic labeling algorithm detecting up to 32 cerebral vessels including arteries and veins, based on 20 data sets of time-resolved contrast-enhanced angiography. The cerebral vessels include: internal carotid arteries (3-segments), middle cerebral arteries (M1), anterior cerebral artery (ACA,A1), ACA (A2), vertebral arteries, basilar artery, posterior cerebral arteries, external carotid, occipital arteries, superficial temporal arteries, internal jugular veins and the sigmoid, transverse, superior sagittal and straight sinuses. The algorithm’s performance was validated on another 20 data sets demonstrating high precision including for the identification of the fetal posterior communicating artery, a common variant of the blood vessels.}
}
@inproceedings{ISMRM2018_4781,
annote={ISMRM2018_4781},
pages={4781},
file={ISMRM2018_4781.pdf:ISMRM2018_4781.pdf:PDF},
title={Influence of contrast, sequence, threshold and observer on 3D segmentation of the right ventricular outflow tract for intervention planning},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4781.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Barbara Elisabeth Ursula Burkhardt and Nicholas K. Brown and Jaclyn E. Carberry and Marí Nieves Velasco Forte and Nicholas Byrne and Tarique Hussain and Gerald Greil and Animesh Tandon},
abstract={Three-dimensional reconstructions of cardiac magnetic resonance (CMR) datasets vary with contrast, image sequence, segmentation threshold and manual post-processing. These influences need to be assessed before CMR-based models are used for interventional planning. Three-dimensional segmentations of the right ventricular outflow tract (RVOT) from twelve patients with three different angiography sequences were compared between and within observers using different or the same thresholds. Thresholding was sequence-dependent and did not significantly change object volumes. Minimal diameters of 3D reconstructed RVOTs showed clinically significant variation with different thresholds and between observers. Interventional planning should rely on source images, not three-dimensional reconstructions, for quantitative information.}
}
@inproceedings{ISMRM2018_4782,
annote={ISMRM2018_4782},
pages={4782},
file={ISMRM2018_4782.pdf:ISMRM2018_4782.pdf:PDF},
title={Aortic 4D Flow {MRI} Data Analysis in Bicuspid Aortic Valve Disease in Under 15 Minutes},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4782.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Amer Ahmed Syed and Daniel Zachary Gordon and Jeremy D Collins and Alireza Sojoudi and Qiao Wei and Xuexin Gao and Michael B Scott and Bradley D Allen and James C Carr and Michael Markl},
abstract={One of the main challenges to the efficient application of 4D flow MRI is related to cumbersome, time-consuming and non-standardized data analysis. The purpose of this study was to test the efficiency and inter-observer reproducibility of a dedicated analysis workflow by using a 4D flow MRI tool in a cohort of 20 BAV patients. We showed that 4D flow MRI can visualize BAV mediated changes on aortic outflow and quantify associated changes in flow dynamics. We demonstrated the potential of an optimized data analysis workflow to perform standardized 4D flow MRI processing in a short time and with good-to-excellent reproducibility.}
}
@inproceedings{ISMRM2018_4783,
annote={ISMRM2018_4783},
pages={4783},
file={ISMRM2018_4783.pdf:ISMRM2018_4783.pdf:PDF},
title={Deep Learning and Compressed Sensing: Automated Image Quality Assessment in Iterative Respiratory-Resolved Whole-Heart {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4783.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Robin Demesmaeker and Jérôme Yerly and John Heerfordt and Tobias Kober and Pier Giorgio Masci and Dimitri Van De Ville and Matthias Stuber and Davide Piccini},
abstract={We aim at creating a link between compressed sensing (CS) reconstruction and automated image quality (IQ) assessment using deep learning. An automated image quality assessment algorithm based on a deep convolutional neural regression network trained to evaluate the quality of whole-heart MRI datasets is used to assess IQ at every iteration of a respiratory motion-resolved CS reconstruction. Not only IQ evolution as assessed by the network visually correlates with the CS cost function, but the neural network is able to distinguish the image quality of different respiratory phases with high correlation to visual expert assessment.}
}
@inproceedings{ISMRM2018_4784,
annote={ISMRM2018_4784},
pages={4784},
file={ISMRM2018_4784.pdf:ISMRM2018_4784.pdf:PDF},
title={Deep Learning for Automated Medical Image Quality Assessment: Proof of Concept in Whole-Heart Magnetic Resonance Imaging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4784.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Robin Demesmaeker and John Heerfordt and Tobias Kober and Jérôme Yerly and Pier Giorgio Masci and Dimitri Van De Ville and Matthias Stuber and Davide Piccini},
abstract={We aim at developing a fully automated algorithm which quantitatively gauges the quality of medical images using deep learning to mimic human perception. An automated image quality assessment algorithm based on a deep convolutional neural regression network is designed, optimized, trained, validated and tested on a clinical database of 3D whole-heart cardiac MRI scans. The algorithm was successfully trained and validated, yielding a regression performance in the range of the intra- and inter-observer agreement. These results show the relevance of deep learning concepts to image quality analysis, in particular to volumetric cardiac MR imaging.}
}
@inproceedings{ISMRM2018_4785,
annote={ISMRM2018_4785},
pages={4785},
file={ISMRM2018_4785.pdf:ISMRM2018_4785.pdf:PDF},
title={Real-World Clinical Performance of Deep Learning for Quantification and Segmentation of Biventricular Cardiac Size and Function},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4785.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Tara Retson and Evan Masutani and Courtney Chen and Jesse Lieman-Sifry and Felix Lau and Matthieu Le and Sean Sall and Daniel Golden and Albert Hsiao},
abstract={In this study of routine clinical cardiac MRIs performed for a typical range of clinical indications, we examined the effectiveness of deep learning (DL) for real-world automated quantitative analysis of cardiac size and biventricular function. We find that automated measurements correlate well with skilled readers. While the variation between DL quantification and experts lie within the range seen between experts, there remain several observed failure modes which may benefit from expert supervision. The combination of DL automation with specialist oversight may reduce the time burden of manual segmentation, improve physician efficiency and promote technique accessibility.}
}
@inproceedings{ISMRM2018_4786,
annote={ISMRM2018_4786},
pages={4786},
file={ISMRM2018_4786.pdf:ISMRM2018_4786.pdf:PDF},
title={Cloud-based, {GPU}-accelerated computation of Lagrangian Coherent Structures in 4D flow enables near-instant blood flow visualization},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4786.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Johannes Töger and Einar Heiberg and Christos Xanthis},
abstract={Intracardiac blood flow dynamics depicted using 4D flow magnetic resonance imaging is increasingly used for analysis of cardiac health. Lagrangian Coherent Structures (LCS) is a powerful blood flow analysis tool, with applications in diastolic dysfunction and separating flowing blood with different behavior. However, use of LCS has been limited by long computation times. Therefore, a cloud-based computation engine for LCS analysis was developed, incorporating acceleration with graphical processing units (GPU:s). A speedup factor of up to 23 times is realized, enabling sub-second LCS computation times. Furthermore, the cloud platform makes rapid LCS analysis possible without investing in expensive GPU hardware.}
}
@inproceedings{ISMRM2018_4787,
annote={ISMRM2018_4787},
pages={4787},
file={ISMRM2018_4787.pdf:ISMRM2018_4787.pdf:PDF},
title={Deep Learning Image Classification for Automatic Frequency Adjustment in High Field Cardiac {MR} Imaging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4787.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={James W Goldfarb and Jie Jane Cao},
abstract={Deep learning using a 3D CNN is a viable solution for the determination of the center frequency at high fields for cardiac imaging. It can quickly provide similar results to an expert observer. In the future, the strategy may be applicable to improved frequency resolution and to frequency adjustments outside of the frequency scout range. This strategy should make 3T cardiac MR imaging accessible to a wider audience.}
}
@inproceedings{ISMRM2018_4788,
annote={ISMRM2018_4788},
pages={4788},
file={ISMRM2018_4788.pdf:ISMRM2018_4788.pdf:PDF},
title={Augmenting the interpretation of cardiac {MRI} by biomechanical modeling: Application to tetralogy of Fallot},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4788.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Radomir Chabiniok and Reagan M. Tompkins and Maria Gusseva and Animesh (Aashoo) Tandon and Gerald Greil and Philippe Moireau and Dominique Chapelle and Tarique Hussain},
abstract={We propose connecting the acquisition and processing of cardiovascular MR (CMR) data with biomechanical cardiac modeling. Physical and physiological character predisposes biomechanical models to predictivity and CMR data turn them into patient-specific regime. A high computational demand is addressed by applying a spatially-reduced model: the geometry and kinematics are simplified, but all other physical properties kept. The approach is illustrated by example of Tetralogy of Fallot patients, in whom we are able to access the myocardial contractility pre- and post-pulmonary valve replacement aiming at deciding on optimal therapy timing – the problem that has not been completely solved by sole CMR.}
}
@inproceedings{ISMRM2018_4789,
annote={ISMRM2018_4789},
pages={4789},
file={ISMRM2018_4789.pdf:ISMRM2018_4789.pdf:PDF},
title={Implementation of Cardiac {MRF} in Gadgetron for Online Reconstruction},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4789.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={James Ahad and Wei-Ching Lo and Jesse Hamilton and Dominique Franson and Yun Jiang and Nicole Seiberlich},
abstract={Cardiac MRF is a unique MRF technique that requires a new dictionary for each acquisition to account for heart rate variability. Dictionary simulation presents a barrier for accessibility to cardiac MRF techniques due to the lack of tools at the scanner. To this end, Bloch simulation tools were developed on the Gadgetron platform to allow for online dictionary simulation and pattern matching reconstruction. Results between prior MATLAB implementations and Gadgetron implementation were in agreement. Future work in optimization may allow for data feedback from the scanner, reducing the need for additional scan time for accurate quantification of T1 and T2 maps.}
}
@inproceedings{ISMRM2018_4790,
annote={ISMRM2018_4790},
pages={4790},
file={ISMRM2018_4790.pdf:ISMRM2018_4790.pdf:PDF},
title={Improved motion correction for myocardial T1 map and {ECV} map},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4790.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Pan ki Kim and Chul Hwan Park and Yoo Jin Hong and Byoung Wook Choi},
abstract={Chemical Exchange Saturation Transfer (CEST) has been attracting attention as a molecular imaging method to investigate myocardial muscle energetics according to creatine changes. In this study, we proposed a robust CEST imaging technique from cardiac and respiratory motion using golden angle radial readout to achieve CEST imaging at the heart of the rat. We investigated the feasibility of the proposed method for the creatine phantom and a normal rat.}
}
@inproceedings{ISMRM2018_4791,
annote={ISMRM2018_4791},
pages={4791},
file={ISMRM2018_4791.pdf:ISMRM2018_4791.pdf:PDF},
title={Python graphical user interface with deep learning-based segmentation for cardiac {LV} analysis},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4791.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yoon-Chul Kim and Kwanghee Choi and Yeon Hyeon Choe},
abstract={The purpose of this study is to develop a deep learning algorithm for myocardial segmentation and apply it to a Python graphical user interface for cardiac MR image processing and analysis. We used a U-net architecture to simultaneously segment endocardial and epicardial borders. For training data, we used publicly available data and our internal data, both of which are from cardiac cine imaging. When the trained model was used in our Python GUI, myocardial segmentation exhibited moderate accuracy in cine data as well as in perfusion data.}
}
@inproceedings{ISMRM2018_4792,
annote={ISMRM2018_4792},
pages={4792},
file={ISMRM2018_4792.pdf:ISMRM2018_4792.pdf:PDF},
title={A powerful Matlab software platform for assessment of streamlined methods involved in quantification of {MR} myocardial perfusion},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4792.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Clément Daviller and Thomas Grenier and Carole Frindel and Pierre Croisille and Magalie Viallon},
abstract={Quantification of myocardial perfusion by MRI requires a wise combination of advanced and complex techniques from images acquisition, segmentation, deconvolution and/or modelling prior deriving perfusion indexes estimations. Accuracy/reproducibility of measures are crucial for medical diagnostic but rely on the optimization of many algorithms. Hence, the latter techniques at each step shall be made available to the community, challenged and improved for optimal state-of-the-art implementation. We propose a software platform that can easily integrate any methods addressing issues or limitations at each step of the process, integrating sharpened tools for precise assessment of individual step to global pipeline performances.}
}
@inproceedings{ISMRM2018_4793,
annote={ISMRM2018_4793},
pages={4793},
file={ISMRM2018_4793.pdf:ISMRM2018_4793.pdf:PDF},
title={Magnetic resonance imaging of the right ventricle: a simple scheme for self-correction of partial volume effect},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4793.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Bård Andre Bendiksen and Lili Zhang and Ivar Sjaastad and Emil Knut Stenersen Espe},
abstract={Magnetic resonance imaging (MRI) of the right ventricle (RV) offers important diagnostic information. However, analysis of RV MRI images is hampered by the crescent shape of the RV. In particular, pixels at the blood-myocardium border may contain signal from both blood and myocardium, hindering accurate analysis of ventricular volumes or mass. Here, we propose an easily implementable correction algorithm for analysis of standard CINE MRI image stacks, without the need for special acquisition. The proposed algorithm offers improved accuracy, in addition to more consistent RV mass estimates from CINE images of the heart in end systole and end diastole.}
}
@inproceedings{ISMRM2018_4794,
annote={ISMRM2018_4794},
pages={4794},
file={ISMRM2018_4794.pdf:ISMRM2018_4794.pdf:PDF},
title={4D Segmentation of Whole-heart Cine Cardiovascular Magnetic Resonance Imaging in Congenital Heart Disease},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4794.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jay B. Patel and Ruizhi Liao and Andrew J. Powell and Polina Golland and Mehdi Hedjazi Moghari},
abstract={3D cine whole-heart cardiovascular magnetic resonance (MR) imaging promises to enable more accurate quantitative evaluation of cardiac function. To extract volumetric measurements of heart chambers and vascular structures from 3D cine datasets, we utilize a graph cuts segmentation algorithm and a deformable registration method. Our measurements differ from those acquired from the conventional 2D cine images, suggesting measurements of ventricular volume based on 2D cine lack accuracy. Clinical evaluation of heart function can therefore be improved by using 3D cine cardiovascular MR imaging coupled with automatic whole heart segmentation.}
}
@inproceedings{ISMRM2018_4795,
annote={ISMRM2018_4795},
pages={4795},
file={ISMRM2018_4795.pdf:ISMRM2018_4795.pdf:PDF},
title={Rigid co-registration for {MOLLI}, a clinical test.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4795.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yadong Cui and Min Zhang and Xiaoqi Wang and Min Chen},
abstract={T1 quantification requires acquisition of multiple images at a sequence of delay times to derive the T1 recovery curve. Modified look-locker inversion recovery (MOLLI) is one of the most commonly used techniques. However, motion between these image acquisitions, especially at different heartbeats, often results in artifacts. In this work, we evaluated motion correction via a novel rigid co-registration based on images at a series time of delay along the T1 relaxation to eliminate the respiratory and cardiac motion artifacts.
}
}
@inproceedings{ISMRM2018_4796,
annote={ISMRM2018_4796},
pages={4796},
file={ISMRM2018_4796.pdf:ISMRM2018_4796.pdf:PDF},
title={4D high-resolution Angiography maps obtained by combining low-resolution time-resolved {ASL} with static high-resolution Time-of-Flight data},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4796.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Thomas Lindner and Naomi Larsen and Olav Jansen and Michael Helle},
abstract={In this study a method to post-process Arterial Spin Labeling (ASL) and Time-of-Flight (TOF) data is presented. The time-resolved low-resolution images of ASL are mapped onto static high-resolution TOF images to create high-resolution time-resolved angiograms.}
}
@inproceedings{ISMRM2018_4797,
annote={ISMRM2018_4797},
pages={4797},
file={ISMRM2018_4797.pdf:ISMRM2018_4797.pdf:PDF},
title={Improving Cerebrovascular Reactivity Assessment Using High-Resolution {MB}-{EPI} Multi-Delay {PCASL} Imaging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4797.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Xiufeng Li and Nicholas Evanoff and Lynn E. Eberly and David Tupper and Anne M. Murray and Gregory J. Metzger and Donald R. Dengel},
abstract={Arterial spin labeling (ASL) imaging with a respiratory challenge can provide both quantitative baseline cerebral blood flow and the assessment of the cerebrovascular reactivity (CVR), an index for cerebrovascular function. However, to date, low-resolution and single-delay ASL imaging is primarily applied to assess CVR and therefore limited. We proposed and successfully applied high-resolution multi-delay pseudo-continuous ASL (PCASL) imaging using a slice accelerated EPI readout for respiratory challenge studies. The study results suggest that the respiratory challenge can induce significant changes in arterial transit time (ATT) and that the estimates of ATT from the multi-delay imaging protocol are critical to achieve unbiased CVR measurements.}
}
@inproceedings{ISMRM2018_4798,
annote={ISMRM2018_4798},
pages={4798},
file={ISMRM2018_4798.pdf:ISMRM2018_4798.pdf:PDF},
title={Reduced cerebral blood flow and oxygen consumption in asymptomatic unilateral carotid stenosis patients assessed by arterial spin labeling and multi-parametric quantitative {BOLD} imaging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4798.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jens Goettler and Stephan Kaczmarz and Claus Zimmer and Christian Sorg and Christine Preibisch and Fahmeed Hyder},
abstract={Assessing cerebral hemodynamics and oxygen consumption in patients with clinically asymptomatic, high-grade internal carotid artery stenosis is crucial to estimate risk of stroke and cognitive impairment. Here, 23 patients with unilateral high-grade carotid stenosis and 24 age-matched healthy controls underwent a range of MRI scans, including quantitative BOLD, DSC and pCASL imaging to assess relative oxygen extraction (OEF), blood flow (CBF) and oxygen consumption (CMRO
2). Both CBF and CMRO
2 were reduced on the stenosis side, indicating that the proposed easily applicable MR-protocol is useful to estimate even subtle CBF and CMRO
2 changes in carotid stenosis patients.}
}
@inproceedings{ISMRM2018_4799,
annote={ISMRM2018_4799},
pages={4799},
file={ISMRM2018_4799.pdf:ISMRM2018_4799.pdf:PDF},
title={4D Flow {MRI} analysis of cerebral blood flow before and after high-flow {EC}-{IC} bypass surgery for {ICA} aneurysm},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4799.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Erika Orita and Tetsuro Sekine and Yasuo Murai and Ryo Takagi and Yasuo Amano and Takahiro Ando and Kotomi Iwata and Makoto Obara and Yoshio Matsumura and Shin-ichiro Kumita},
abstract={The purpose of this study was to clarify the change of hemodynamics after high-flow extracranial-intracranial (EC-IC) bypass surgery for ICA aneurysm by using time-resolved 3D-phase contrast (4D Flow) MRI. We enrolled 11 patients who underwent high-flow EC-IC bypass surgery. They underwent 4D Flow MRI before and after the surgery. We evaluated the blood flow direction of the circle of Willis. We measured blood flow volume (BFV) of bilateral ICAs, BA and bypass artery. Seven of 11 patients exhibited collateral retrograde flow in the circle of Willis after surgery. The BFV of contralateral ICA and BA and total brain BFV statistically increased after surgery. While, there was no evidence of post-operative hyperperfusion in any cases. 4D Flow MRI could quantify the change of hemodynamics after the high-flow bypass surgery.}
}
@inproceedings{ISMRM2018_4800,
annote={ISMRM2018_4800},
pages={4800},
file={ISMRM2018_4800.pdf:ISMRM2018_4800.pdf:PDF},
title={Prominent vessels on quantitative susceptibility maps indicate microvascular pathology after experimental cerebral ischemia and reperfusion},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4800.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Markus Vaas and Andreas Deistung and Jürgen R Reichenbach and Annika Keller and Anja Kipar and Jan Klohs},
abstract={We tested the utility of quantitative susceptibility mapping (QSM) to assess vascular abnormalities in a mouse model of experimental stroke. We acquired high resolution gradient echo data of mice at different time points after ischemia/reperfusion for computation of susceptibility maps. Prominent vessels with increased magnetic susceptibility values were detected surrounding the ischemic lesion at all times, indicating an increase in oxygen extraction. Immunohistochemistry revealed narrowed capillaries and dilated larger vessels. Thus, prominent vessels are an important indicator of underlying microvascular pathology and may by pivotal for diagnosis and therapeutic decision making in stroke patients.}
}
@inproceedings{ISMRM2018_4801,
annote={ISMRM2018_4801},
pages={4801},
file={ISMRM2018_4801.pdf:ISMRM2018_4801.pdf:PDF},
title={Analyzation and Optimization of Simultaneous Non-Contrast Angiography and intraPlaque Hemorrhage ({SNAP}) Magnetic Resonance Angiography in Intracranial Vascular Imaging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4801.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yuhui Xiong and Le He and Yu Ma and Xihai Zhao and Chun Yuan and Hua Guo},
abstract={In this study, we used theoretical simulation and in-vivo scan validation to explore the relationship between intracranial SNAP-MRA signal and blood flow velocity to explain why the performance of SNAP-MRA may vary greatly between healthy people and patients with neurodegenerative diseases. We also found the way to re-optimize the scan parameters (TI and flip angle) to enhance the SNAP-MRA signal and acquire high quality intracranial SNAP-MRA.}
}
@inproceedings{ISMRM2018_4802,
annote={ISMRM2018_4802},
pages={4802},
file={ISMRM2018_4802.pdf:ISMRM2018_4802.pdf:PDF},
title={3D high resolution Black Blood({BB}) Multiple Echo({ME}) T2* Imaging Technique for Quantitative Ferumoxytol Imaging on Delayed Scans},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4802.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Seong-Eun Kim and J Scott Scott McNalley and Adam de Havenon and Dennis L Parker and Gerald S Treiman},
abstract={The purpose of this work was to develop a 3D BB ME T2* Imaging technique to to allow quantitative ferumoxytol imaging on delayed scans by measuring T2* in intracranial atherosclerotic plaque(ICAD). Post-gadoliniun enhancement in ICAD may be related to endothelial dysfunction or breakdown or secondary to plaque inflammation. Delayed ferumoxytol imaging allows intravascular clearance with retention in the macrophages present in vulnerable atherosclerotic plaque. We developed a 3D BB ME T2* imaging technique to allow quantitative ferumoxytol imaging on delayed scans by measuring T2* in ICAD.}
}
@inproceedings{ISMRM2018_4803,
annote={ISMRM2018_4803},
pages={4803},
file={ISMRM2018_4803.pdf:ISMRM2018_4803.pdf:PDF},
title={Influences of smoking on cerebral arteriolar vasomotor function: evaluation by using magnetic resonance signal fluctuation},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4803.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yusuke Nitanda and Minghui Tang and Toru Yamamoto},
abstract={The vasodilation and vasoconstriction properties of cerebral arterioles (arteriolar vasomotor function) would be a biomarker of early diagnosis of dementia. Although the vasodilation ability has been studied by using vasodilators such as Diamox, these vasodilators cause non-natural extreme vasodilation. Focusing on the natural arteriolar vasomotion induced by respiratory variation of blood CO
2, we have reported a method to evaluate cerebral arteriolar vasomotor function by spectral analysis of fluctuation of venous MRI signal. In this study, we improved our method and applied it to young smokers and demonstrated the degeneration of arteriolar vasomotor function after a few years of chronic smoking.}
}
@inproceedings{ISMRM2018_4804,
annote={ISMRM2018_4804},
pages={4804},
file={ISMRM2018_4804.pdf:ISMRM2018_4804.pdf:PDF},
title={Dynamic Susceptibility Contrast and Dynamic Contrast Enhanced Perfusion Performed in a Single Acquisition Using m{DIXON} Quant},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4804.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Brian Johnson and Sandeep Ganji and Ivan Dimitrov},
abstract={This work investigates the use of mDIXON Quant as a perfusion technique to acquire dynamic susceptibility contrast (DSC) and dynamic contrast enhanced (DCE) scans in a single acquisition. The use of multi-echo mDIXON Quant for assessment of perfusion can be used to eliminate the need for split dosing and allows for acquiring DCE and DSC in a single acquisition. Elimination of a split contrast dose will remove contamination from changes in T1, T2 and T2*. This technique can potentially simplify the workflow for the DCE- based perfusion MRI imaging and reduce overall scan time.}
}
@inproceedings{ISMRM2018_4805,
annote={ISMRM2018_4805},
pages={4805},
file={ISMRM2018_4805.pdf:ISMRM2018_4805.pdf:PDF},
title={Initial experience using combined quantitative susceptibility mapping and quantitative bold oxygen level dependent imaging ({QSM}+q{BOLD}) oxygen extraction fraction for evaluation of acute ischemic stroke},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4805.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Shun Zhang and Junghun Cho and Thanh D. Nguyen and Pascal Spincemaille and Wenzhen Zhu and Yi Wang},
abstract={Oxygen extraction fraction (OEF) reflects tissue oxygen consumption, which is very useful to predict the outcome of ischemic stroke in metabolic level. In this work, we evaluate a combined quantitative susceptibility mapping (QSM) and quantitative bold oxygen level dependent (qBOLD) method for measuring OEF based on MRI multi echo gradient echo (GRE) imaging in 11 acute ischemic stroke patients. OEF maps displayed various patterns both in the lesion and in the ASL-CBF/DWI mismatch area, consistent with previous PET studies. OEF with a heterogeneous increase within the lesion or in the CBF/DWI mismatch area may represent salvageable ischemic tissue, while OEF decrease may suggest irreversible infarct.}
}
@inproceedings{ISMRM2018_4806,
annote={ISMRM2018_4806},
pages={4806},
file={ISMRM2018_4806.pdf:ISMRM2018_4806.pdf:PDF},
title={Myelin imaging may reveal ischemic microstructural damage correlated with neurocognitive dysfunction in patients with moyamoya disease},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4806.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Shoko Hara and Masaaki Hori and Yasuaki Tsurushima and Yoji Tanaka and Taketoshi Maehara and Shigeki Aoki and Tadashi Nariai},
abstract={To investigate myelin structural damage caused by chronic ischemia, we applied myelin imaging using magnetization transfer saturation (MTsat) method to 15 patients with moyamoya disease (36.6±11.6-year-old) and 10 normal volunteers (28.4±5.2-year-old). Although many patients received bypass surgery in the past and currently had good hemodynamic status, we found myelin volume fraction (MVF) was significantly lower and g-ratio was significantly higher in the patient group compared to normal controls. Moreover, regional MVF values showed some correlation with neurocognitive tests. This finding suggests myelin damage occurs in moyamoya disease, is associated with neurocognitive dysfunction and is perhaps irreversible.}
}
@inproceedings{ISMRM2018_4807,
annote={ISMRM2018_4807},
pages={4807},
file={ISMRM2018_4807.pdf:ISMRM2018_4807.pdf:PDF},
title={The relationship between advanced perfusion {MRI} and measurements of vessel size in human gliomas using image-guided stereotactic biopsies and quantitative immunohistochemistry},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4807.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ararat Chakhoyan and Kevin Leu and Robert J. Harris and Mitra D. Harati and William Yong and Albert Lai and Phioanh Nghiemphu and Linda Liau and Noriko Salamon and Whitney B. Pope and Timothy F. Cloughesy and Benjamin Ellingson},
abstract={Following an accurate sampling of glioma tissues with 3D T1w-MRI coordinates, we quantified VSI from multi-echo spin-and-gradient echo DSC perfusion as well as from CD31 staining. Eleven patients were included in this retrospective study with in total 30 evaluated targets. We demonstrated the robustness of VSI quantification by MRI. These maps showed a high sensibility and specificity for tumor grading. Finally, in comparison with classical DSC approaches for rCBV estimations, the quantification of VSI could be automated in clinical settings and enhance our understanding of micro and macro-vessel evolution in glioma patients.}
}
@inproceedings{ISMRM2018_4808,
annote={ISMRM2018_4808},
pages={4808},
file={ISMRM2018_4808.pdf:ISMRM2018_4808.pdf:PDF},
title={Atherosclerotic Diseases in Entire Craniocervical Arteries and Aortic Arch and Stroke Risk: A 3D Multicontrast {MR} Vessel Wall Imaging Study},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4808.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Dongye Li and Wei Dai and Ying Cai and Yongjun Han and Guoen Yao and Huijun Chen and Chun Yuan and Xihai Zhao},
abstract={Vulnerable atherosclerotic plaque in intracranial and extracranial carotid arteries and aortic arch is one of major causes of ischemic stroke. This study investigated the characteristics of atherosclerotic plaques in the craniocervical arteries and aortic arch and their relationships with stroke risk using 3D multicontrast MR vessel wall imaging. We found that high risk atherosclerotic plaques were most prevalent in intracranial arteries among three vascular beds. Combination of the maximum wall thickness in intracranial with extracranial carotid arteries might be a stronger predictor for cerebral acute ischemic lesions than that in each vascular bed alone.}
}
@inproceedings{ISMRM2018_4809,
annote={ISMRM2018_4809},
pages={4809},
file={ISMRM2018_4809.pdf:ISMRM2018_4809.pdf:PDF},
title={Magnetic Susceptibility Mapping Reveals Altered Vein Oxygenation in Patients with Brain Arteriovenous Malformations: A Preliminary Study},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4809.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Emma Biondetti and Alvaro Rojas Villabona and Hans Rolf Jäger and David L Thomas and Karin Shmueli},
abstract={Arteriovenous malformations (AVMs) are vascular anomalies characterised by arteriovenous shunting with the lack of a capillary bed. Since the veins that drain an AVM contain arterialised blood, they would be expected to have a higher venous oxygen saturation (SvO
2) than normal veins. Due to the paramagnetic properties of deoxyhaemoglobin, SvO
2 can be calculated using magnetic susceptibility mapping (SM). Here, we calculated SM-based SvO
2 in five patients with a brain AVM. We found higher SvO
2 in the AVM draining veins compared to normal veins, showing that SM might be a valuable tool to study AVM physiology.}
}
@inproceedings{ISMRM2018_4810,
annote={ISMRM2018_4810},
pages={4810},
file={ISMRM2018_4810.pdf:ISMRM2018_4810.pdf:PDF},
title={Surveillance of unruptured intracranial saccular aneurysms using non-contrast 3D black blood {MRI}: comparison of 3D {TOF} and {CE}-{MRA} with {DSA}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4810.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Chengcheng Zhu and Xinrui Wang and Bing Tian and Qi Liu and Christopher Hess and David Saloner and Jianping Lu},
abstract={Patients with unruptured intracranial aneurysms (UIAs) routinely undergo surveillance imaging to monitor the growth. CTA and CE-MRA provide good accuracy in measuring size relative to gold standard 3D DSA, but require contrast agent and/or have radiation, which is undesirable for repeated imaging. We compared three MRI techniques on 58 aneurysms: 1) 3D non-contrast black blood MRI (SPACE), 2) 3D TOF 3) CE-MRA, against gold standard 3D DSA. SPACE was in excellent agreement with DSA, better than CE-MRA and TOF. Our results support the use of non-contrast SPACE for surveillance of UIA in the clinical setting.}
}
@inproceedings{ISMRM2018_4811,
annote={ISMRM2018_4811},
pages={4811},
file={ISMRM2018_4811.pdf:ISMRM2018_4811.pdf:PDF},
title={Hypertension induces changes in brain network organization},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4811.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Guixiang Ma and Bokai Cao and Philip S. Yu and Ann Ragin},
abstract={Hypertension is a risk factor for dementia and age-related neurological disorders. Analysis of resting state fMRI for brain network organization may capture early changes induced by hypertension. This investigation examined characteristic network metrics in young, otherwise asymptomatic adults (n=27; mean age 34) classified for hypertension. Path length was the most discriminating global metric. Differences in node clustering were identified using machine learning, including for subcortical regions that have been identified as brain network hubs (thalamus, hippocampus and putamen). These are critical structures for memory, supporting a potential role in cognitive deterioration and dementia and the premise of hub vulnerability.}
}
@inproceedings{ISMRM2018_4812,
annote={ISMRM2018_4812},
pages={4812},
file={ISMRM2018_4812.pdf:ISMRM2018_4812.pdf:PDF},
title={Oxygen Extraction Fraction and R2* Mapping in Cerebrovascular Disease using an Acetazolamide Challenge.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4812.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Christopher Leatherday and Seena Dehkharghani and Fadi Nahab and Jason W. Allen and Junjie Wu and Ranliang Hu and Deqiang Qiu},
abstract={Increased cerebral oxygen extraction fraction (OEF) in cerebrovascular disease is linked with a greatly elevated risk of recurrent ischemic stroke. The current gold standard for OEF imaging is Oxygen-15 PET; which is less widely available and more expensive than MRI and includes an ionizing radiation dose. We studied quantitative susceptibility mapping derived OEF maps and R2* mapping combined with an Acetazolamide challenge in a group of unilateral CVD patients and found increased OEF and reduced cerebrovascular reactivity in the disease-affected hemisphere using these methods. With further refinement, these techniques may provide a clinical alternative to
15O-PET for OEF imaging.}
}
@inproceedings{ISMRM2018_4813,
annote={ISMRM2018_4813},
pages={4813},
file={ISMRM2018_4813.pdf:ISMRM2018_4813.pdf:PDF},
title={Effects of physical exercise on hippocampal volume and vasculature in young adults},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4813.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Antonia Kaiser and Michelle M Solleveld and Linda Knutsson and Matthias JP van Osch and Liesbeth Reneman and Paul J Lucassen and Anouk Schrantee},
abstract={The underlying neurobiological changes of exercise-induced hippocampal volume increases are poorly understood, but a substantial role for vascular plasticity, such as perfusion and angiogenesis, has been suggested. We here studied the effect of a high and low intensityexercise intervention on the hippocampal volume and vasculature. Exercise did not induce hippocampal volume changes, despite a baseline association between fitness and volume. Interestingly, improved fitness resulted in increased hippocampal cerebral blood flow (CBF) (p=0.01) and gray matter CBF (p=0.07). No effect on cerebral blood volume was found. This may suggest that perfusion effects are not hippocampus-specific.}
}
@inproceedings{ISMRM2018_4814,
annote={ISMRM2018_4814},
pages={4814},
file={ISMRM2018_4814.pdf:ISMRM2018_4814.pdf:PDF},
title={New vision of tuberous sclerosis complex on 7-Tesla {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4814.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Kaibao Sun and Jianfei Cui and Bo Wang and Tao Jiang and Zhongwei Chen and Fei Cong and Yan Zhuo and Rong Xue and Shuli Liang and Lin Chen},
abstract={Tuberous sclerosis complex is a multisystem genetic disorder characterized by the growth of numerous tuberous lesions in brain. However, few in vivo studies on TSC have focused on venous structure changes, their association with TSC lesions and iron accumulation in basal ganglia. 7T susceptibility weighted imaging was performed on eleven TSC patients in comparison with fifteen age- and sex-matched healthy controls. The tubers might develop along penetrating veins. There might be coexistence of iron deposition and calcification in basal ganglia. These in vivo 7T MRI findings provided new perspectives for better understanding the brain pathology in patients with TSC.}
}
@inproceedings{ISMRM2018_4815,
annote={ISMRM2018_4815},
pages={4815},
file={ISMRM2018_4815.pdf:ISMRM2018_4815.pdf:PDF},
title={Increased intracellular volume fraction, orientation dispersion and diffusion kurtosis in the brain are associated with poor functional outcome in comatose cardiac arrest patients},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4815.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ona Wu and Eric S Rosenthal and Brittany B. Mills and Gaston Cudemus-Deseda and Brian L Edlow and W. Taylor Kimberly and Ming Ming Ning and William A Copen and Pamela W. Schaefer and Joseph T Giacino and David M Greer},
abstract={Cardiac arrest patients who are comatose after restoration of spontaneous circulation were prospectively studied to determine whether changes to intracellular volume fraction (ICVF), orientation dispersion and diffusion kurtosis imaging (DKI) can be used to discriminate patients likely to recover consciousness. Subjects who failed to wake up had greater median ICVF and DKI compared to subjects who woke up. Increases in ICVF and DK are associated with more severe acute ischemic brain injury. Multi-shell diffusion imaging may help identify patients that may recover consciousness.}
}
@inproceedings{ISMRM2018_4816,
annote={ISMRM2018_4816},
pages={4816},
file={ISMRM2018_4816.pdf:ISMRM2018_4816.pdf:PDF},
title={Hemodynamic Biomarkers to Assess Disease Severity in Patients with Intracranial Atherosclerotic Disease using Dual-Venc 4D Flow {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4816.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Alireza Vali and Maria Aristova and Sameer A. Ansari and Ayesha Muzaffar and Shyam Prabhakaran and Michael Markl and Susanne Schnell},
abstract={To conduct a comprehensive assessment of hemodynamics in patients with intracranial atherosclerotic disease (ICAD), an automated analysis tool was developed to quantify 4D flow MRI data, including extraction of pressure gradient and flow resistance across the ICAD stenosis and flow and peak velocity asymmetry indices. For three ICAD cases with identical degree of stenosis, the results demonstrated variability in both flow resistance and flow asymmetry indices. With the inclusion of more patients spanning a spectrum of stenosis degrees, it may be possible to demonstrate the utility of flow resistance as a new metric for characterizing the hemodynamic impacts of ICAD.}
}
@inproceedings{ISMRM2018_4817,
annote={ISMRM2018_4817},
pages={4817},
file={ISMRM2018_4817.pdf:ISMRM2018_4817.pdf:PDF},
title={Rapid Quantitative Susceptibility Mapping of Intracranial Hemorrhage using Echo Planar Imaging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4817.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ashmita De and Hongfu Sun and Ahmed Elkady and Derek Emery and Kenneth Butcher and Alan H Wilman},
abstract={Intracranial hemorrhage(ICH) accounts for about 20\% of strokes. Quantitative Susceptibility Mapping (QSM) may be valuable for tracking iron changes in ICH. Here we apply Echo Planar Imaging (EPI) for rapid QSM at 3.0 T in hemorrhage patients. The acquisition time is only 9 sec without parallel imaging and 27 sec if parallel imaging is considered to maintain high resolution, appropriate echo time and minimize blurring effects. High correlation was observed for ICH area and mean susceptibility between standard QSM and EPI-QSM in hemorrhage. Hence EPI-QSM method has potential for clinical ICH studies when time is a limiting factor.}
}
@inproceedings{ISMRM2018_4818,
annote={ISMRM2018_4818},
pages={4818},
file={ISMRM2018_4818.pdf:ISMRM2018_4818.pdf:PDF},
title={A comparison of cerebrovascular reactivity at 1.5 and 3T in cerebral small vessel disease patients},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4818.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Michael S Stringer and Gordon W Blair and Yulu Shi and Iona Hamilton and Ian Marshall and Fergus Doubal and Michael J Thrippleton and Joanna M Wardlaw},
abstract={Cerebrovascular reactivity can be measured using blood oxygen level dependent (BOLD) MRI and is a potential mechanism in cerebral small vessel disease (SVD). Investigations of the effect of field strength on CVR have been limited, particularly in patient groups. In this study CVR measurements within a series of preselected regions in SVD patients were assessed at 1.5 and 3T. Mean CVR was greater at 3T in 12 of the 14 regions, however differences, as assessed with Bland-Altman plots, were within reasonable limits. These results point to the importance of considering other scanner specific factors beyond field strength when measuring CVR.
}
}
@inproceedings{ISMRM2018_4819,
annote={ISMRM2018_4819},
pages={4819},
file={ISMRM2018_4819.pdf:ISMRM2018_4819.pdf:PDF},
title={Motor recovery after initial severe stroke: confronting kinematics with brain activations},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4819.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Liesjet E.H. van Dokkum and Isabelle Laffont and Denis Mottet and Jerome Froger and Alain Bonafe and Nicolas Menjot-de Champfleur and Emmanuelle le Bars},
abstract={To maximize motor recovery of the upper-limb post-stroke, rehabilitation should be adapted to the individual patient. This requires the identification of motor recovery markers in relation to corresponding brain activations. During elbow flexion/extension, kinematic analysis was confronted with corresponding fMRI activations, comparing 21 participants post-stroke with 13 controls. This provided insight into the underlying functioning and organisation of motor control, switching between ‘automatic’ feed-forward and ‘conscious’ feedback control. Post-stroke, the latter strategy was applied with an additional role for visualisation and the contralesional hemisphere, whereby different kinematic profiles were related to different brain activations, opening doors to personalized rehabilitation.}
}
@inproceedings{ISMRM2018_4820,
annote={ISMRM2018_4820},
pages={4820},
file={ISMRM2018_4820.pdf:ISMRM2018_4820.pdf:PDF},
title={Monitoring diabetic stroke response to novel p38 {MAPK} inhibitor therapy using dynamic contrast enhanced magnetic resonance imaging ({DCE}-{MRI})},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4820.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yu Cai and Shenghong Ju},
abstract={We monitored the increased disruption of blood brain barrier (BBB) by DCE-MRI at acute-stage of ischemic stroke in T2DM mice non-invasively. Furthermore, administration of novel P38 inhibitor is a promising way to promote BBB recovery in diabetic stroke and the therapeutic efficacy can be monitored by DCE-MRI.}
}
@inproceedings{ISMRM2018_4821,
annote={ISMRM2018_4821},
pages={4821},
file={ISMRM2018_4821.pdf:ISMRM2018_4821.pdf:PDF},
title={Prognostication of stroke recovery using structural connectivity},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4821.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Xiaopei Xu and Kui Kai Lau and Leonard SW Li and Yuen Kwun Wong and Christina Yau and Henry KF Mak and Queenie Chan and Edward S Hui},
abstract={We aim to investigate the longitudinal changes in the structural brain network of patients with acute subcortical ischemic infarct in the motor system and the relation between motor recovery and network measures. Our results showed that the nodal degree of parahippocampus, amygdala, calcarine fissure, cuneus and fusiform gyrus increased with time after stroke and that network topology measured at acute phase was associated with the recovery of motor function at 6 months after stroke. These findings suggested that network topology could potentially be a prognostic indicator of motor recovery for patients with acute subcortical ischemic infarct in the motor system.}
}
@inproceedings{ISMRM2018_4822,
annote={ISMRM2018_4822},
pages={4822},
file={ISMRM2018_4822.pdf:ISMRM2018_4822.pdf:PDF},
title={A cost effective, 3D printed vasculature phantom for {MR} imaging of stroke},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4822.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Rashmi Rao and Priyanka Harish and Nithin N Vajuvalli and Arush Honnedevasthana Arun and Ashwini Kumnoor and Sairam Geethanath},
abstract={Stroke is mainly caused due to hemorrhage or ischemia due to infarct. Current work aims to develop a phantom which can mimic structure and function of a human brain stroke using 3D print technology. The normal human brain vasculature was printed using Poly Lactic Acid. An ischemic infarct was mimicked using Poly Vinyl Alcohol and a cerebral aneurysm was integrated to the vasculature to demonstrate simultaneous onset of hemorrhagic and ischemic stroke. Waterflow to the phantom was introduced by integrating the peristaltic pump. T1, T2 , DW images and T 1and T2maps were generated which depict the stroke vasculature}
}
@inproceedings{ISMRM2018_4823,
annote={ISMRM2018_4823},
pages={4823},
file={ISMRM2018_4823.pdf:ISMRM2018_4823.pdf:PDF},
title={Reproducibility of {BOLD} delay perfusion measurements in acute stroke patients},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4823.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ahmed A Khalil and Ayse Ceren Tanritanir and Ulrike Grittner and Arno Villringer and Jochen Fiebach and Ralf Mekle},
abstract={To assess perfusion in ischemic stroke is an important task in clinical diagnosis. In this context, a technique sensitive to the delay of blood-oxygenation-level-dependent (BOLD) oscillations at rest called BOLD delay has been proposed. In this study, the reproducibility of this technique in acute stroke patients was examined. Magnitude differences between perfusion measurements from two timepointswere calculated and evaluated in a statistical model. In particular, the effect of head motion was considered. Reproducibility was found to be limited by motion, but the magnitude of the observed variations was small compared to delays observed due to hypoperfusion in stroke patients.}
}
@inproceedings{ISMRM2018_4824,
annote={ISMRM2018_4824},
pages={4824},
file={ISMRM2018_4824.pdf:ISMRM2018_4824.pdf:PDF},
title={Multi-parametric {MR} Microscopy of Cerebral Thrombi as a Tool for Prediction of Thrombectomy Procedure Times in Stroke Therapy},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4824.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Franci Bajd and Jernej Vidmar and Eduard Kralj and Andrej Fabjan and Fajko Bajrović and Igor Kocijančič and Zoran Miloševič and Miran Jeromel and Igor Serša},
abstract={In this study human cerebral thrombi were quantitatively characterized after their acquisition by mechanical thromectomy. The characterization was based on multi-parametric MRI using 3D T
1-weighted imaging and ADC and T
2 mapping. In the study it was shown that thrombi complex structure can be assessed by ADC and T2 mapping MRI mapping techniques and that the MRI maps of thrombi can be used for prognosis of the mechanical thrombectomy procedure times prior to the interventions.}
}
@inproceedings{ISMRM2018_4825,
annote={ISMRM2018_4825},
pages={4825},
file={ISMRM2018_4825.pdf:ISMRM2018_4825.pdf:PDF},
title={Can susceptibility weighted imaging indicate the ischemic penumbra in patients with acute infarction in middle cerebral artery?},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4825.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yu Luo and Linglei Meng and Yongming Zhou and Shuang Xia and E.Mark Haacke},
abstract={
1.Purpose to evaluate the penumbra in acute ischemic stroke by quantitative mismatch between susceptibility weighted imaging(SWI) and diffusion weight imaging(DWI) in comparison with perfusion weighted imaging(PWI) and diffusion weight imaging(DWI) mismatch. 2.
Method 85 eligible patients were enrolled with acute ischemic stroke who underwent MR scan including DWI, SWI and PWI before treatment within 12 hours after symptom onset. SWI-DWI mismatch was demarcated by the volume of asymmetrical prominent cortical veins(APCV)region in SWI MIP extending beyond the volume of infarct core segmentation of ADC maps. PWI-DWI mismatch was determined by using infarct core and perfusion deficits segmented from ADC and Tmax maps. 3.
Result 41 cases have SWI-DWI mismatch,while 43 cases have PWI-DWI mismatch in totally 85 patients. 42 cases have neither SWI-DWI mismatch nor PWI-DWI mismatch. Only 2 cases have PWI-DWI mismatch without SWI-DWI mismatch. None has SWI-DWI mismatch without PWI-DWI mismatch. There is no a significant difference between SWI-DWI and PWI-DWI in showing mismatch with MCA stroke(P<0.01).The NIHSS of patients with SWI-DWI mismatch was statistically higher compared to the patients without SWI-DWI mismatch (t=-4.956, P<0.01). The NIHSS of patients was also statistically higher with PWI-DWI mismatch in comparison with none PWI-DWI mismatch(t=-4.481, P<0.01). 4.
Conclusion APCV in SWI might to be a good instrument to indicate the ischemic penumbra as well as PWI. SWI may be an alternative to PWI in some stroke cases.}
}
@inproceedings{ISMRM2018_4826,
annote={ISMRM2018_4826},
pages={4826},
file={ISMRM2018_4826.pdf:ISMRM2018_4826.pdf:PDF},
title={Oxygen extraction fraction is elevated in acute stroke with evidence of preserved metabolism: a quantitative susceptibility {MRI} study},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4826.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Audrey P. Fan and Ahmed A. Khalil and Jochen Fiebach and Arno Villringer and Greg Zaharchuk and Kersten Villringer and Claudine J. Gauthier},
abstract={We utilized a novel MRI susceptibility method to quantify oxygen extraction fraction (OEF) in cortical vessels of 22 patients with acute stroke. The observed OEF ratio between affected and contralateral hemispheres depended on patient perfusion status and tended to normalize (decrease) in follow-up scans on average 3 days later. Stroke cases with substantial perfusion-diffusion mismatch (indicative of potentially salvageable penumbra) showed the greatest OEF elevation (OEF ratio = 1.2 ± 0.1). Patients with large mismatch also showed an inverse relationship between OEF and relative cerebral blood flow (from dynamic susceptibility contrast), suggestive of mechanisms to maintain tissue oxygen metabolism even in ischemic tissue.}
}
@inproceedings{ISMRM2018_4827,
annote={ISMRM2018_4827},
pages={4827},
file={ISMRM2018_4827.pdf:ISMRM2018_4827.pdf:PDF},
title={Unruptured Intracranial Aneurysms: Relationship between Wall Enhancement and Rupture Risk Factors Based on High-resolution Magnetic Resonance Imaging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4827.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Chengcheng Zhu and Xinrui Wang and Qi Liu and Christopher Hess and David Saloner and Jianping Lu},
abstract={Wall enhancement (AWE) of intracranial aneurysms (IAs) on high-resolution black blood MRI has been described in ruptured aneurysms. This study investigated 103 unruptured saccular IAs and aims to assess the association between AWE and traditional risk factors and estimated one-year and five-year rupture risk estimated from previous large trails. We found aneurysms with AWE had more than 3 times higher estimated rupture risk (one-year and 5-year, 2.2\% and 6.7\%) than aneurysms without AWE (0.6\% and 2.0\%) and AWE was associated with traditional risk factors (size, location, symptoms). Identifying AWE may improve the risk assessment of IAs.}
}
@inproceedings{ISMRM2018_4828,
annote={ISMRM2018_4828},
pages={4828},
file={ISMRM2018_4828.pdf:ISMRM2018_4828.pdf:PDF},
title={Quantifying dynamic {CBF} changes in 4-day follow up after carotid endarterectomy using 3D p{CASL}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4828.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ting Wang and Bo Bu and Bing Wu and Lin Ma and Xin Lou},
abstract={Hyperperfusion syndrome was a severe complications of carotid endarterectomy (CEA), the routine measurement for preventing this was to take antihypertensive drugs for at least one week after operative. But there were no definite criteria to assess whether this method was reasonable and appropriate; our objective was to detect dynamic CBF changes in 4-day follow up after CEA using 3D pCASL technique. It is seen that compared to patients before CEA, both the ipsilateral and opposite CBF values were increased in various time points after CEA (P<0.05), whereas, the bilateral CBF values shows no significant differences (P>0.05). This shown that 3D pCASL is sensitive to temporal hemodynamic changes after CEA and may provide a quantitative criterion for assessing antihypertensive drugs taken. Also the observed increases shortly in the first and the second day after operations may suggest for potential drug intervention in case of post-CEA complications.}
}
@inproceedings{ISMRM2018_4829,
annote={ISMRM2018_4829},
pages={4829},
file={ISMRM2018_4829.pdf:ISMRM2018_4829.pdf:PDF},
title={The Value of Magnetic Resonance Black-blood Imaging in Differentiating Acute and Chronic Cerebral Venous Thrombosis},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4829.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Xiaoxu Yang and Fang Wu and Ye Wu and Tianyi Qian and Xianggong Duan and Xiangying Du and Xunming Ji and Qi Yang},
abstract={This study aims to demonstrate the value of magnetic resonance black-blood imaging (MRBTI) for differentiating acute and chronic cerebral venous thrombosis (CVT) as well as the diagnosis accuracy of CVT in segment levels. The SNR and CNR of the acute CVT group were significantly higher than that of the chronic group. The sensitivity and specificity of MRBTI were 95.6\% (152 /159) and 98.0\% (352 /359), respectively. Furthermore, the sensitivity of MRBTI in detecting acute thrombus is up to 100\%, compared with 88.5\% in the chronic group, which means MRBTI has high sensitivity for early diagnosis.}
}
@inproceedings{ISMRM2018_4830,
annote={ISMRM2018_4830},
pages={4830},
file={ISMRM2018_4830.pdf:ISMRM2018_4830.pdf:PDF},
title={Vessel Encoded Arterial Spin Labeling Evaluation of Collateral Circulation in Symptomatic and Asymptomatic Patients with Internal Carotid Artery or Middle Cerebral Artery Occlusion},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4830.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jinhao Lyu and Xiaoxiao Ma and Yina Lan and Lin Ma and Xin Lou},
abstract={Symptomatic and asymptomatic patients with internal carotid artery (ICA) or middle cerebral artery (MCA) occlusion have the different prognosis. The present study had evaluated collateral circulation by Vessel Encoded Arterial Spin Labeling (VE-ASL) and cerebral vasoreactivity by mean transit time (MTT) obtained by Dynamic susceptibility contrast in symptomatic and asymptomatic patients with unilateral ICA and/or MCA occlusion. The study had found that the intensity of collateral in asymptomatic patients was significantly better than symptomatic patients while MTT showed no significant differences, which indicate that hemodynamic impairments in symptomatic patients with ICA/MCA occlusion may be mainly induced by the insufficiency of collateral circulation.}
}
@inproceedings{ISMRM2018_4831,
annote={ISMRM2018_4831},
pages={4831},
file={ISMRM2018_4831.pdf:ISMRM2018_4831.pdf:PDF},
title={Proximal Internal Carotid Artery Stenosis Associates with Diffuse Wall Thickening in Petrous Arterial Segment of Moyamoya Disease Patients: A 3D {MR} Vessel Wall Imaging Study},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4831.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Xiaoyi Chen and Jian Wang and Bing Zhang and Dongye Li and Huiyu Qiao and Shuai Liu and Yongjun Han and Hualu Han and Yongbo Yang and Fei Zhou and Xueping Li and Xihai Zhao},
abstract={It has been shown that rapid reduction of lumen diameter at the proximal ICA can be seen in moyamoya disease (MMD) patients. The arterial wall thickness at downstream of proximal ICA may aggravate cerebral ischemia and affect the outcome of revascularization. This study sought to investigate the association between proximal ICA stenosis and diffuse wall thickening in ipsilateral petrous ICA in MMD patients. We found that proximal ICA stenosis was significantly associated with wall thickness (r = 0.434, p<0.001) and presence of diffuse wall thickening (odds ratio=4.433, 95\% confidence interval 1.980–9.925, p<0.001) in ipsilateral petrous ICA in MMD patients.}
}
@inproceedings{ISMRM2018_4832,
annote={ISMRM2018_4832},
pages={4832},
file={ISMRM2018_4832.pdf:ISMRM2018_4832.pdf:PDF},
title={Cerebrovascular resistance responses to {CO}2 improve after revascularization surgery},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4832.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Larissa McKetton and Olivia Sobczyk and Julien Poublanc and Kevin Sam and Adrian P. Crawley and Lakshmikumar Venkat Raghavan and James Duffin and Joseph A. Fisher and David J. Mikulis},
abstract={The cerebral hemodynamics of patients undergoing revascularization surgery for intracranial steno-occlusive disease (IC-SOD) were assessed by deriving an estimate of their cerebrovascular resistance response to CO
2 from their BOLD response to CO
2. Significant improvements were found in the sigmoid parameters describing their resistance responses.}
}
@inproceedings{ISMRM2018_4833,
annote={ISMRM2018_4833},
pages={4833},
file={ISMRM2018_4833.pdf:ISMRM2018_4833.pdf:PDF},
title={Predicting Hyperperfusion syndrome by measurement of leptomenigeal collateral and preoperative cerebral blood flow in patients with unilateral internal carotid artery stenosis},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4833.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yina Lan and Jinhao Lyu and Jianxun Qu and Lin Ma and Xin Lou},
abstract={Hyperperfusion syndrome (HPS) is a rare but potentially fatal postoperative complication after revascularization, while preoperative predictor of HPS had not been fully established. We used pseudo continuous arterial spin labeling (pCASL) to investigate the correlation between the collateral flow proportion and the elevated cerebral blood flow (CBF) ratio relative to the preoperative CBF in patients with unilateral internal carotid artery (ICA) stenosis. A significant correlation was observed between the collateral flow proportion and the elevated CBF ratio . (r =0.588, P =0 .01). As an indication, HPS are likely to occur in patients with low preoperative CBF and good collateralization.}
}
@inproceedings{ISMRM2018_4834,
annote={ISMRM2018_4834},
pages={4834},
file={ISMRM2018_4834.pdf:ISMRM2018_4834.pdf:PDF},
title={Carotid stenosis: a risk factor for white matter disease even at presymptomatic stage},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4834.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Pedro Henrique Rodrigues da Silva and Ana Paula Afonso Camargo and Antonio Carlos Santos Senra Filho and Luiz Otavio Murta Junior and Octávio Marques Pontes Neto and Renata Ferranti Leoni},
abstract={Studies have suggested that cerebral white matter hyperintensity (WMH) is due to hypertension and is associated with carotid artery stenosis (CAS). However, it is unclear whether this association is attributable to effects on WM and how asymptomatic CAS contributes to it. Therefore, we aimed to assess the association between ACAS and WMH lesions and its relationship with cognitive decline using MRI to provide information that may help predicting cases at risk of brain ischemia. Our data showed that ACAS is associated with WMH lesions and cognitive decline, indicating that ACAS, in addition to age, is likely to cause WM lesions.}
}
@inproceedings{ISMRM2018_4835,
annote={ISMRM2018_4835},
pages={4835},
file={ISMRM2018_4835.pdf:ISMRM2018_4835.pdf:PDF},
title={Brain morphometric changes and functional connectivity alterations in post-stroke fatigue},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4835.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Milanka Visser and Thomas Lillicrap and Carlos Garcia-Esperon and Bénédicte Maréchal and Mark Parsons and Christopher Levi and Andrew Bivard},
abstract={Debilitating fatigue is the most common consequence of stroke, however there are no known clinical or radiological biomarkers associated with post-stroke fatigue. We assessed differences in regional brain volumes obtained from T1-weighted, high-resolution structural scans between stroke survivors with and without severe fatigue. Differences were observed in the volume of the globus pallidus and putamen, as well as the ipsilesional temporal, parietal and frontal lobe. The mentioned morphological differences between stroke survivors with and without severe fatigue have also been reported in multiple sclerosis and Parkinson’s-related fatigue, suggesting a possible common mechanism.}
}
@inproceedings{ISMRM2018_4836,
annote={ISMRM2018_4836},
pages={4836},
file={ISMRM2018_4836.pdf:ISMRM2018_4836.pdf:PDF},
title={Preoperative predictors of hyperperfusion after {CEA}: a study using vessel selective {ASL}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4836.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Tianye Lin and Zhichao Lai and Yuelei Lyu and Zhentao Zuo and Bing Wu and Jianxun Qu and Hui You and Bo Hou and Changwei Liu and Feng Feng},
abstract={To identify preoperative predictors for cerebral hyperperfusion (CHS) after CEA based on vessel selective ASL. The perfusion volume of each brain feeding artery and the corresponding mean CBF in each perfusion volume before and after CEA were calculated. It was found that the sum of perfusion volumes corresponding to LICA, RICA and VBA (TotalPerVol) and the preoperative territory perfusion of the surgery side (preCBF_surg) was inversely correlated with the degree of CBF increase. The result indicated that tASL and ASL were useful in predicting cerebral hyperperfusion.}
}
@inproceedings{ISMRM2018_4837,
annote={ISMRM2018_4837},
pages={4837},
file={ISMRM2018_4837.pdf:ISMRM2018_4837.pdf:PDF},
title={Evaluation of Tranvascular Water Exchange Index ({WEI}) in post Thrombectomy Patients},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4837.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Young Ro Kim and Jerold L. Boxerman},
abstract={The dynamic evolution of vascular impairment following thrombotic stroke has important clinical implications for designing effective management and treatment strategies. In the current study, we quantified the rate of water exchange across the blood-brain barrier (BBB) via water exchange index (WEI) in clinical patients undergone thrombectomy. Although extravasation of Gd-DTPA was not observed in most of the patients, the WEI was significantly elevated in both infarct and peri-infarct areas, revealing compromised integrity of the BBB.}
}
@inproceedings{ISMRM2018_4838,
annote={ISMRM2018_4838},
pages={4838},
file={ISMRM2018_4838.pdf:ISMRM2018_4838.pdf:PDF},
title={Correlation between Intracranial Artery Atherosclerotic Disease and the Integrity of Circle of Willis in Symptomatic Patients: A 3D {MR} Vessel Wall Imaging Study.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4838.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yilan Xu and Dongye Li and Zhuozhao Zheng and Chun Yuan and Xihai Zhao},
abstract={This study investigated the correlation between intracranial artery atherosclerotic disease and the integrity of communicating arteries in circle of Willis in symptomatic patients using MR imaging. We found that the intracranial artery stenosis was significantly associated with presence of anterior and posterior communicating arteries. Our findings suggest that the intracranial artery stenosis might be an independent indicator for the integrity of circle of Willis. Our data also suggest that, with the progression of intracranial artery stenosis, collateral circulation tends to be integrated from the anterior to posterior communicating arteries.}
}
@inproceedings{ISMRM2018_4839,
annote={ISMRM2018_4839},
pages={4839},
file={ISMRM2018_4839.pdf:ISMRM2018_4839.pdf:PDF},
title={Brain Perfusion and Structure Variation of Patients with Unilateral Middle Cerebral Artery Stenosis},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4839.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Shuang Yan and Tianyi Qian and Mingli Li and Li Zhang and Zhengyu Jin},
abstract={To investigate the brain structure variation of patients with chronic unilateral middle cerebral artery (MCA) stenosis, a volume-based quantitative segmentation method was used to measure the morphological changes of brain structure. A correlation analysis was performed to find the relationship between the morphometry and cerebral blood perfusion. The results showed that the patients had atrophy in many brain regions within the MCA territory. And the perfusion status may have impact on the atrophy process.}
}
@inproceedings{ISMRM2018_4840,
annote={ISMRM2018_4840},
pages={4840},
file={ISMRM2018_4840.pdf:ISMRM2018_4840.pdf:PDF},
title={Quantitative Cerebral Blood Flow Measured with Arterial Spin Labeling {MRI} in the Unaffected Contralateral Brain Hemisphere Predicts Outcome in Acute Ischemic Stroke},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4840.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Thoralf Thamm and Jia Guo and Jarrett Rosenberg and Tie Liang and Michael P Marks and Soren Christensen and Huy M Do and Stephanie M Kemp and Emily A Ryan and Tudor G Jovin and Bart P Keogh and Jenny Chen and Maarten G Lansberg and Greg W Albers and Greg Zaharchuk},
abstract={During acutestroke, perfusion of the ischemic penumbra might be sustained by both collaterals and elevated systemic blood pressure. Arterial Spin Labeling (ASL) is an MR imaging tool to quantify Cerebral Blood Flow (CBF) non-invasively. We focused on the non-affected brain hemisphere and utilized this contralateral CBF (cCBF) as an imaging biomarker for late neurological outcome prediction. Stroke patients were dichotomized by the median cCBFinto high (>39 mL/100g/min) and low (<39 mL/100g/min) cCBF. Our analysis revealed that high cCBFpredicts goodneurological outcome at day 90 after stroke.}
}
@inproceedings{ISMRM2018_4841,
annote={ISMRM2018_4841},
pages={4841},
file={ISMRM2018_4841.pdf:ISMRM2018_4841.pdf:PDF},
title={Association between Diffusion Weighed Imaging Measured Pretreatment Ischemic Volume and Functional Outcome in Ischemic Stroke},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4841.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yu XIE and Catherine Oppenheim and Francis Guillemin and Vincent Gautheron and Benjamin Gory and Hélène Raoult and Sébastien Soize and Bailiang CHEN and Jacques Felblinger and Gabriela Hossu and Serge Bracard},
abstract={The association between pretreatment ischemic volume (PIV) measured on diffusion weighted images (DWI) and functional outcome after mechanical thrombectomy is of great clinical importance but has yet to be determined. We analyzed 298 ischemic stroke patients from the multicentric study THRACE. Our results showed that increased PIV was an independent predictor for a lower probability of functional independence, a less favorable degree of disability and a higher mortality rate. PIV measured on DWI is a valuable early predictor for functional outcome in ischemic stroke patients and thus can contribute to patient selection for optimal therapeutic intervention.}
}
@inproceedings{ISMRM2018_4842,
annote={ISMRM2018_4842},
pages={4842},
file={ISMRM2018_4842.pdf:ISMRM2018_4842.pdf:PDF},
title={Comparison of {ASL}-{MRA} and 3D {TOF}-{MRA} in patients with transit ischemic attack},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4842.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yan Wang and Jing Chen and Chuanchen Zhang and Jianxun Qu and Mingzhen Wu},
abstract={A comparison of ASL-MRA and TOF-MRA was performed for patients suffered from TIA. TOF-MRA is superior to ASL-MRA in morphological assessment of the stenosis arteries. However, ASL-MRA can reflect more hemodynamic information of the blood supply arteries for the hypoperfusion area.
}
}
@inproceedings{ISMRM2018_4843,
annote={ISMRM2018_4843},
pages={4843},
file={ISMRM2018_4843.pdf:ISMRM2018_4843.pdf:PDF},
title={{MRI}-derived Oxygen Metabolism and Neovascularization Characterization for Grading and {IDH} Gene Mutation Detection of Gliomas},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4843.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Andreas Stadlbauer and Max Zimmermann and Arnd Dörfler and Stefan Oberndorfer and Michael Buchfelder and Gertraud Heinz and Karl Rössler},
abstract={The purpose was to explore the diagnostic performance of combined physiological MRI of oxygen metabolism and neovascularization for glioma grading and characterization of isocitrate-dehydrogenase-1 (IDH1) gene mutation status. 83 patients with glioma WHO°II-IV were examined using vascular architecture mapping (VAM) and multiparametric quantitative BOLD (mp-qBOLD). Neovascularization correlated with increasing WHO° and microvessel type indicator (MTI) had the best diagnostic performance (AUC=0.782) for differentiation between glioma WHO°III and IV. IDH1-mutation was associated with significantly decreased cerebral metabolic rate of oxygen (CMRO
2; P=0.037) in glioma WHO°II and significantly increased (P=0.013) MTI in glioma WHO°III, resulting in best diagnostic performance for IDH1-mutation detection.}
}
@inproceedings{ISMRM2018_4844,
annote={ISMRM2018_4844},
pages={4844},
file={ISMRM2018_4844.pdf:ISMRM2018_4844.pdf:PDF},
title={Vascular Hysteresis Loops and Vascular Architecture Mapping in Patients with Glioblastoma treated with Antiangiogenic Therapy},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4844.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Andreas Stadlbauer and Max Zimmermann and Stefan Oberndorfer and Arnd Dörfler and Michael Buchfelder and Gertraud Heinz and Karl Rössler},
abstract={Glioblastoma are among the most vascularized of all solid tumors and attractive targets for antiangiogenic therapies. Antiangiogenic therapy response assessment in glioblastoma is challenging due to decreased vessel permeability and diminished contrast agent extravasation. Here, we investigated the variability of vascular hysteresis loop (VHL) shapes and the spatial heterogeneity of neovascularization using vascular architecture mapping (VAM) in patients with recurrent glioblastoma during bevacizumab mono-therapy. Responding, non-responding, progressive and remote-progressive tumor areas were observed. Analysis of VHLs in combination with VAM biomarkers may lead to a new perspective on investigating the spatial heterogeneity of neovascularization in glioblastoma during antiangiogenic therapy.}
}
@inproceedings{ISMRM2018_4845,
annote={ISMRM2018_4845},
pages={4845},
file={ISMRM2018_4845.pdf:ISMRM2018_4845.pdf:PDF},
title={Diagnostic Accuracy of 2-Hydroxyglutarate Magnetic Resonance Spectroscopy in Newly-Diagnosed Brain Mass and Suspected Recurrent Gliomas},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4845.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Alexander P. Lin and Min Zhou and Huijun Liao and Raymond Huang},
abstract={Previous studies have reported the utility of 2-hydroxyglutarate magnetic resonance spectroscopy (2HG MRS) in diagnosing isocitrate dehydrogenase (IDH) status, which is of great value for patient management. We determined the optimal thresholds of single voxel spectroscopy (SVS) and chemical shift imaging (CSI) 2HG MRS in differentiating IDH-mutant gliomas from non-IDH-mutant controls and then determined the diagnostic accuracy in two prospective cohorts of patients. We show that 2HG MRS provided diagnostic utility for IDH-mutant gliomas both preoperatively and at time of suspected tumor recurrence. Our findings may provide guidance for devising optimal MRS imaging protocol tailored to specific clinical settings.}
}
@inproceedings{ISMRM2018_4846,
annote={ISMRM2018_4846},
pages={4846},
file={ISMRM2018_4846.pdf:ISMRM2018_4846.pdf:PDF},
title={Mutual Information: Depicting the Interdependence of Perfusion and Diffusion Magnetic Resonance Imaging in Glioblastoma Patients},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4846.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Chao Li and Shuo Wang and Turid Torheim and Florian Markowetz and Stephen J Price},
abstract={The mismatch between energy demands of tumorgrowth and heterogeneous blood supply may cause variations is associated with tumoraggressiveness. Multi-parametric imaging may enable incorporation of complementary imaging modalities. However, finding validated surrogates to depict the interrelation between imaging modalities remains a challenge. We used the mutual information to describe the interrelation between the perfusion and diffusion imaging. The results showed that the higher values of mutual information may contribute to a worse patient survival. The chemical shift imaging results suggested that the higher mutual information may be correlated with a more migratory phenotype.}
}
@inproceedings{ISMRM2018_4847,
annote={ISMRM2018_4847},
pages={4847},
file={ISMRM2018_4847.pdf:ISMRM2018_4847.pdf:PDF},
title={Radiomics of {MRI} at Diagnosis is Predictive of Extreme Survival in Glioblastoma Multiforme},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4847.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Olya Stringfield and Mahmoud Abdalah and Sandra Johnston and Nicolas Rognin and Yoganand Balagurunathan and John Arrington and Kristin Swanson and Kathleen M. Egan and Robert A. Gatenby and Natarajan Raghunand},
abstract={We retrospectively analyzed pre-treatment MR scans in two cohorts diagnosed with Glioblastoma. The Long-Term Survival (LTS) group survived >36 months post-diagnosis, while the Short-Term Survival (STS) group survived ≤18 months. The discovery cohort included 22 LTS patients and 22 STS patients and the validation cohort consisted of 15 patients, each. Tumor voxels were clustered on post-contrast T1w and FLAIR sequences into 6 distinct “habitats”. Radiomic features were extracted from both sequences. The enhancement value on T1w and fraction of Habitat 6 (high signal on T1w and FLAIR) were significantly higher in the LTS groups compared to the STS groups.}
}
@inproceedings{ISMRM2018_4848,
annote={ISMRM2018_4848},
pages={4848},
file={ISMRM2018_4848.pdf:ISMRM2018_4848.pdf:PDF},
title={Radiological Assessment of Vascular Supply of Intracranial Meningeomas by Superselective Arterial Spin Labelling.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4848.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ulf Jensen-Kondering and Michael Helle and Thomas Lindner and Arya Nabavi and Olav Jansen},
abstract={Detailed information on the extent and ratio of blood supply is required to assess the feasibility of presurgical embolisation procedures of intracranial meningeomas. This study investigates the feeding vasculature to intracranial meningeomas using superselective ASL. In 31 prospectively included patients harboring a total of 42 meningeomas, superselective ASL was performed to visualize the contribution of blood supply to the tumor and rated by two readers. We demonstrated that superselective ASL is capable of identifying and quantifying the contribution of feeding arteries in intracranial meningeomas. Agreement with gold standard DSA is also demonstrated.}
}
@inproceedings{ISMRM2018_4849,
annote={ISMRM2018_4849},
pages={4849},
file={ISMRM2018_4849.pdf:ISMRM2018_4849.pdf:PDF},
title={Autopsy analysis of the overlap of radiomic profiles associated with poor overall survival and predictive maps of tumor cellularity in glioblastoma patients},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4849.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Sarah L Hurrell and Sean McGarry and Elizabeth Cochran and Jennifer Connelly and Scott Rand and Wade Mueller and Peter S LaViolette},
abstract={Multiparametric MRI radiomic profiles (RPs) of de novo glioblastoma (GBM) brain tumors have been shown to predict patient prognosis prior to treatment. This study compares prognostic RPs to predictive maps of tumor cellularity derived from radiological-pathological (rad-path) correlation to determine the convergence of both imaging biomarkers. We find that RPs associated with poor prognosis co-localize with high cellularity, both predicted and pathologically confirmed in 6 patients assessed at autopsy.}
}
@inproceedings{ISMRM2018_4850,
annote={ISMRM2018_4850},
pages={4850},
file={ISMRM2018_4850.pdf:ISMRM2018_4850.pdf:PDF},
title={Amide proton transfer-weighted imaging of glioblastoma and metastatic brain tumor: histogram analysis in enhancing tumors and peritumoral regions},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4850.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Kiyohisa Kamimura and Masanori Nakajo and Tomohide Yoneyama and Hirofumi Hirano and Takashi Iwanaga and Yuta Akamine and Jochen Keupp and Takashi Yoshiura},
abstract={To determine whether amide proton transfer-weighted imaging (APTWi) is useful for distinguishing glioblastomas (GBMs) from metastatic brain tumors (Mets), we compared APT-related signal intensity (APTSI) between the two tumor types in the areas of enhancing tumor and peritumoral high signal intensity areas (PHAs) using histogram analysis. In the enhancing tumor, the mean and 90,75,50,25 and 10 percentiles of APTSI histogram were significantly higher in GBMs than in Mets, whereas no APTSI histogram parameters in PHA showed significant difference between GBMs and Mets. APTSI in the areas of enhancing tumor, not in PHA is useful for differentiation between GBMs and Mets.}
}
@inproceedings{ISMRM2018_4851,
annote={ISMRM2018_4851},
pages={4851},
file={ISMRM2018_4851.pdf:ISMRM2018_4851.pdf:PDF},
title={The Influence of Heterogenous Subregions on Predicting {MGMT} Methylation Status of Glioblastomas: A Radiomics Analysis on Multimodal {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4851.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Qiang Tian and Xi Zhang and Lin-feng Yan and Yu-chuan Hu and Yu Han and Ying-zhi Sun and Wen Wang and Guang-bin Cui},
abstract={MGMT promoter methylation is associated with longer survival and better treatment response of GBM patients. Intratumor heterogeneity is partly responsible for inaccurate detection of MGMT status. Therefore, assessing the effect of different heterogenous subregion of GBM on MGMT status would be critical. In this study, a radiomics approach integrated optimal features of heterogenous subregions in multimodal MRI and machine learning model was proposed for effectively predicting MGMT methylation and meanwhile assessing the prediction efficiency of subregions or subregion combinations. The proposed approach achieved a promising MGMT methylation detection performance and indicated that rNEC may play a role in this issue.}
}
@inproceedings{ISMRM2018_4852,
annote={ISMRM2018_4852},
pages={4852},
file={ISMRM2018_4852.pdf:ISMRM2018_4852.pdf:PDF},
title={High-resolution Deuterium {MR} Spectroscopic Imaging of the Warburg Effect in Brain Tumor},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4852.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ming Lu and Xiao-Hong Zhu and Yi Zhang and Walter Low and Wei Chen},
abstract={The best-known metabolic abnormality in brain cancer is the Warburg effect, which shifts the fuel consumption from oxidation towards glycolysis. Recently, we developed a novel in vivo Deuterium (
2H) MR spectroscopic imaging (DMRSI) approach for simultaneously assessing brain glycolysis and oxidation at 16.4 T. In this study, we aimed to image the Warburg effect in a rat model with gliosarcoma using DMRSI with improved resolution. High-resolution quantitative image using the ratio of [lactate] to [glutamate/glutamine] showed a huge contrast between brain tumor and intact tissue and promise to study the decoupling relationship between glycolysis and oxidation in tumor.}
}
@inproceedings{ISMRM2018_4853,
annote={ISMRM2018_4853},
pages={4853},
file={ISMRM2018_4853.pdf:ISMRM2018_4853.pdf:PDF},
title={Edge Contrast of the {FLAIR} Hyperintense Region Predicts Survival in Patients with High Grade Gliomas Following Treatment with Bevacizumab},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4853.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Naeim Bahrami and David Piccioni and Roshan Karunamuni and Nate White and Yu-Hsuan Chang and Tyler Seibert and Rachel Delfanti and Jona jhattangadi-gluth and Nikdokht Farid and Anders M Dale and Carrie McDonald},
abstract={Treatment with bevacizumab is standard of care for recurrent high grade gliomas (HGGs) and the level of border distinctness is a major parameter to monitor the therapy. Previously, the level of border distinctness was defined qualitative. In this study, we calculated the distinctness of the fluid-attenuated inversion recovery (FLAIR) hyperintense border—edge contrast (EC)—and showed it improves the evaluation of response to bevacizumab in patients with HGG. We showed that after bevacizumab, lower EC of the FLAIR hyperintense region was associated with poorer survival among HGG patients. We developed a quantitative parameter to characterize the border of the tumor.}
}
@inproceedings{ISMRM2018_4854,
annote={ISMRM2018_4854},
pages={4854},
file={ISMRM2018_4854.pdf:ISMRM2018_4854.pdf:PDF},
title={True-Diffusion Coefficient Retracted from Intra-Voxel Incoherent Motion ({IVIM}) Can Stratify Biopsy-Approved Infiltrative Edema from Normal Tissue and Active Tumor in Diffuse Brain Gliomas},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4854.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Anahita Fathi Kazerooni and Nima Gilani and Mahnaz Nabil and Mehdi Zeinalizadeh and Kavous Firouznia and Farid Azmoudeh-Ardalan and Mohammad Peikari and Mohammadreza Alviri and Mehrdad Hadavand and Hamidreza Saligheh Rad},
abstract={Infiltration of tumorous cells in the normal brain parenchyma is an intrinsic characteristic of diffuse gliomas and is a determinant factor in tumor recurrence, transformation into malignant form and poor prognosis. The objective of this study was to investigate the role of intra-voxel incoherent motion (IVIM) imaging in characterizing tumor infiltration through localized biopsies. Histopathologically-approved regions of active tumor, infiltrative glioma (edema) and normal tissues were accurately discriminated by true (perfusion-free) diffusion coefficient (D).}
}
@inproceedings{ISMRM2018_4855,
annote={ISMRM2018_4855},
pages={4855},
file={ISMRM2018_4855.pdf:ISMRM2018_4855.pdf:PDF},
title={Characterization of Active and Infiltrative Tumorous Subregions from Normal Tissue in Brain Gliomas Using Multi-Parametric {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4855.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Anahita Fathi Kazerooni and Mahnaz Nabil and Mohammadreza Alviri and Mehdi Zeinalizadeh and Kavous Firouznia and Farid Azmoudeh-Ardalan and Hamidreza Saligheh Rad},
abstract={In this preliminary work, a variety of MRI techniques, including conventional high-resolution T1-weighted, T2-weighted and T2-FLAIR, as well as quantitative techniques comprising of T2-relaxometry, DWI, DTI, DSC-MRI and IVIM derived features were acquired from patients with gliomas. The features extracted from the mentioned images were explored for their potential in stratification of histopathologically-approved samples, labelled as active tumor, infiltrative glioma (edema) and normal brain tissue. Furthermore, the most accurate combination of the features for discrimination of tissue subregions was generated through a machine learning technique.}
}
@inproceedings{ISMRM2018_4856,
annote={ISMRM2018_4856},
pages={4856},
file={ISMRM2018_4856.pdf:ISMRM2018_4856.pdf:PDF},
title={Combined Diffusion Kurtosis Imaging and Dynamic Susceptibility Contrast Magnetic Resonance Perfusion Imaging for In Vivo Molecular Profiling of Human Glioma.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4856.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Johann-Martin Hempel and Jens Schittenhelm and Nils Nüssle and Cornelia Brendle and Benjamin Bender and Ghazaleh Tabatabai and Marco Skardelly and Salvador Castaneda Vega and Ulrike Ernemann and Uwe Klose},
abstract={The purpose of this study was to assess the diagnostic performance of combined DKI and DSC-MRI maps for in vivo assessment of the 2016 WHO integrated glioma grades. Histogram parameters of DKI show a higher diagnostic performance than those of DSC-MRI in stratifying gliomas according to the integrated molecular approach of 2016 CNS WHO. However, DSC-MRI may provide additional insight into the MGMT methylation profile of primary IDH wild-type GBM. Thus, combined DKI and DSC-MRI provide promising potential biomarkers for glioma.}
}
@inproceedings{ISMRM2018_4857,
annote={ISMRM2018_4857},
pages={4857},
file={ISMRM2018_4857.pdf:ISMRM2018_4857.pdf:PDF},
title={Deep-learned 3D black-blood imaging using automatic labeling technique and 3D convolutional neural networks for detection of metastatic brain tumors},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4857.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yohan Jun and Taejoon Eo and Taeseong Kim and Hyungseob Shin and Dosik Hwang and Sohi Bae and Yaewon Park and Hojoon Lee and Byoungwook Choi and Sungsoo Ahn},
abstract={Black-blood (BB) imaging has complementary roles in addition to contrast-enhanced 3D gradient-echo (CE 3D-GRE) imaging for detection of brain metastases. We proposed deep-learned 3D BB imaging with an auto-labeling technique and 3D convolutional neural networks (CNNs) for detecting metastatic brain tumors. On deep-learned BB imaging, vessel signals of the brain were effectively suppressed in all patients. According to per lesion analysis, overall sensitivities were 90.3\% for deep-learned BB and 100\% for original BB. There were eight false positive nodules on original BB and only one on deep-learned BB. Deep-learned 3D BB imaging can be effectively used for detecting metastatic tumors in the brain.}
}
@inproceedings{ISMRM2018_4858,
annote={ISMRM2018_4858},
pages={4858},
file={ISMRM2018_4858.pdf:ISMRM2018_4858.pdf:PDF},
title={High Resolution T1-Perfusion using Compressed-{SENSE} for Glioma Grading},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4858.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Rakesh Kumar Gupta and Indrajit Saha and Anup Singh and Pradeep Kumar Gupta and Rupsa Bhattacharjee and Anandh K Ramaniharan and Rana Patir and Sunita Ahlawat and Jitender Saini and Marc Van Cauteren},
abstract={T1-perfusion MRI derived relative cerebral blood volume (rCBV) is a key bio-marker for pre-surgical grading of gliomas; however, acquiring clinically relevant higher resolution T1-perfusion data with whole brain coverage is challenging due to possible loss in temporal resolution. This study takes the advantage of combining compressed-sensing with SENSE parallel-imaging i.e., Compressed-SENSE (CSENSE), to develop high-resolution whole brain T1-perfusion with improved temporality. The CSENSE enabled T1-perfusion derived rCBV values successfully differentiated high and low grade gliomas and matched with the histopathological grading. The rCBV cut-off value from CSENSE assisted T1-perfusion was similar to the routine T1-perfusion without-CSENSE of histopathology-matched gliomas.}
}
@inproceedings{ISMRM2018_4859,
annote={ISMRM2018_4859},
pages={4859},
file={ISMRM2018_4859.pdf:ISMRM2018_4859.pdf:PDF},
title={Lactate-weighted Chemical Exchange Saturation Transfer (Lactate-{CEST}) Imaging in Glioma Patients at 7 Tesla},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4859.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Daniel Paech and Jan-Eric Meissner and Markus Wennmann and Andreas Korzowski and Alexander Radbruch and Martin Bendszus and Wolfgang Wick and Andreas Unterberg and Peter Bachert and Mark Edward Ladd and Heinz-Peter Schlemmer},
abstract={Non-invasive imaging of lactate is of enormous significance, particularly in oncologic diseases or metabolic disorders. In this work, we applied Lactate-weighted Chemical Exchange Saturation Transfer (Lactate-CEST) magnetic resonance imaging (MRI) at 7 Tesla (7T) to newly-diagnosed glioma patients. Lactate-CEST MRI revealed increased levels of lactate production in brain tumors of patients with glioma and could therefore serve as an additional imaging biomarker in diagnostic oncology with implications for biopsy targeting, patient therapy and response monitoring.}
}
@inproceedings{ISMRM2018_4860,
annote={ISMRM2018_4860},
pages={4860},
file={ISMRM2018_4860.pdf:ISMRM2018_4860.pdf:PDF},
title={Advanced {MRI} and {MRS} precursors to progression in Grade {II} and {III} Glioma},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4860.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Tracy L Luks and Yan Li and Marisa LaFontaine and Angela Jakary and Michael Wahl and Susan M Chang and Sarah J. Nelson},
abstract={The goal of this project is to identify serial advanced imaging markers that reveal tumor progression in grade II and III gliomas prior to the Response Assessment in Neuro-Oncology Criteria (RANO) criteria for progression. Serial advanced imaging demonstrated significant changes associated with tumor activity prior to the clinical determination of tumor progression. In diffusion imaging, there were declines in nFA and an increase in nADC in the contrast enhancing lesions. In spectroscopic imaging, there were declines in nNAA and nCRE and increases in nCho, nLIP and nLAC.}
}
@inproceedings{ISMRM2018_4861,
annote={ISMRM2018_4861},
pages={4861},
file={ISMRM2018_4861.pdf:ISMRM2018_4861.pdf:PDF},
title={Volumetric Amide Proton Transfer-Weighted ({APT}w) Image Metrics as Biomarkers for the Identification of Tumor Progression in Patients with Post-treatment Glioblastoma},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4861.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Shanshan Jiang and Hye-Young Heo and Yi Zhang and Jinyuan Zhou},
abstract={We quantified the accuracy of volumetric APTw image derived metrics in identifying recurrent malignant glioma. 31 patients with suspected recurrent glioblastoma underwent a volumetric APTw imaging sequence at 3T. Volumes with Gd-enhancing, FLAIR abnormality and APTw hyperintensity were drawn as regions of interest (ROIs). Ratios and APTw histogram parameters of volumetric ROIs were calculated and analyzed. There were significant differences in multiple parameters between treatment effects and recurrent tumor. APT/Gd and Gd-APT
10\% showed the highest diagnostic performance. FLAIR-Mean showed reasonable diagnostic performance with great operation simplicity.}
}
@inproceedings{ISMRM2018_4862,
annote={ISMRM2018_4862},
pages={4862},
file={ISMRM2018_4862.pdf:ISMRM2018_4862.pdf:PDF},
title={Predicting efficacy of a novel immune stimulator in an animal model of glioblastoma with ferumoxytol cell tracking {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4862.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Runze Yang and A. Max Hamilton and Susobhan Sarkar and Reza Mirzaei and V. Wee Yong and Jeff F. Dunn},
abstract={Treatment of malignant gliomas with immunotherapy has become an important area of exploration. However, one of the major problems in glioma immunotherapy is the lack of sensitive imaging techniques to differentiate tumor progression (detrimental) from pseudoprogression (beneficial, caused by stimulated macrophages). We hypothesized that tracking macrophages is a sensitive way to detect immunotherapy treatment response. We used a novel drug that stimulates the innate immune system and showed that ferumoxytol based cell tracking MRI is a sensitive way to detect monocyte infiltration and predict tumor growth. Ferumoxytol is used clinically, so this method has high potential for clinical translation}
}
@inproceedings{ISMRM2018_4863,
annote={ISMRM2018_4863},
pages={4863},
file={ISMRM2018_4863.pdf:ISMRM2018_4863.pdf:PDF},
title={Late-delayed perfusion decrease following radiochemotherapy in glioblastoma patients},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4863.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jan Petr and Henri JMM Mutsaerts and Ivan Platzek and Vera C Keil and Frank Hofheinz and Iris Asllani and Annekatrin Seidlitz and Marketa Petrova and Esther GC Troost and Mechthild Krause and Jörg van den Hoff},
abstract={Temozolomide-based radiochemotherapy (RCT) is a treatment standard for glioblastoma patients. However, RCT is associated with risks of neurocognitive decline. Perfusion is a possible early marker of tissue damage and has been shown to correlate with cognitive changes in many diseases. Perfusion decrease at 3 to 6 months after RT was recently reported in glioblastoma patients. However, it remains unclear whether the decrease is reversible and thus possibly a precursor of the late-delayed cognitive changes. In this study, we have measured perfusion changes up to 18 months following RCT. No further progress of perfusion deficits was found indicating that the early perfusion decrease is predictive of late perfusion decrease and might thus be connected with cognitive decline.}
}
@inproceedings{ISMRM2018_4864,
annote={ISMRM2018_4864},
pages={4864},
file={ISMRM2018_4864.pdf:ISMRM2018_4864.pdf:PDF},
title={{THE} {CHALLENGE} {OF} {TRACTOGRAPHY} {APPLIED} {TO} {CRANIAL} {NERVES}: {OUR} {EXPERIENCE} {ON} {DESIGN} {OF} {REGIONS} {OF} {INTEREST}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4864.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Timothée Jacquesson and François Cotton and Justine Bosc and Moncef Berhouma and Emmanuel Jouanneau and Arnaud Attye and Carole Frindel},
abstract={Recent studies have demonstrated diffusion tensor imaging tractography of cranial nerves (CNs). Spatial and angular resolution, however, is limited with this imaging technique. In this study, we reported our experience in CNs tractography detailing the influence of ROI design. We demonstrated that understanding in detail the key role of ROI design and its influence helps to provide coherent tracts. We expect this work to enable a more reliable CNs tractography and made it a useful tool for surgical planning of complex skull base tumors.}
}
@inproceedings{ISMRM2018_4865,
annote={ISMRM2018_4865},
pages={4865},
file={ISMRM2018_4865.pdf:ISMRM2018_4865.pdf:PDF},
title={23Na {MRI} at 7 Tesla for Early Response Assessment in Patients with Glioblastoma and Skull Base Meningioma},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4865.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Sebastian Regnery and Daniel Paech and Heiz-Peter Schlemmer and Mark E. Ladd and Armin M. Nagel and Stefan Rieken and Jürgen Debus and Sebastian Adeberg and Nicolas G.R. Behl},
abstract={Radiotherapy is a cornerstone in the treatment of glioblastoma and skull base meningioma. Here, the first results of a prospective longitudinal study employing 23Na MRI for the response evaluation of glioblastoma and skull base meningioma patients during radiotherapy are presented. The study results show that radiation treatment of glioblastoma leads to considerable changes in sodium concentrations within the tumor and the surrounding edema that are dependent on treatment response.}
}
@inproceedings{ISMRM2018_4866,
annote={ISMRM2018_4866},
pages={4866},
file={ISMRM2018_4866.pdf:ISMRM2018_4866.pdf:PDF},
title={{MRI} Texture Analysis based on 3D tumor measurement in the identification and prognosis of Gliomas with {IDH}1 Mutations},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4866.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Liang Han and Yanwei Miao and Junyi Dong and Xiaoxin Li and Yangyingqiu Liu and Shiyun Tian and Mame Fatou KEITA and Weiwei Wang and Yan Guo and Qingwei Song},
abstract={The 2016 World Health Organization Classification of Tumors of the Central NervousSystem(CNS) used molecular parameters in addition to histology to define manytumor entities, thus formulating a concept for how CNS tumor diagnosis should bestructured in the molecular era.IDH1 is an important molecular marker which has important clinical significance. The prognosis of gliomas with IDH1 mutation is better than those without one. In general,IDH1is detected by pathological biopsy. In this study, gliomas with or without IDH1 mutation was distinguished by using non-invasive MRI texture analysis based on 3D tumor measurement and then the relationship between MRI texture parameters with survival rate was further assessed.
}
}
@inproceedings{ISMRM2018_4867,
annote={ISMRM2018_4867},
pages={4867},
file={ISMRM2018_4867.pdf:ISMRM2018_4867.pdf:PDF},
title={Single Acquisition Multiparametric {MRI} for Differentiation of Left Ventricular Scar Tissue Composition},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4867.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Zahra Hosseini and Junmin Liu and Nikolaos Tzemos and Raymond Yee and Maria Drangova},
abstract={Cardiac MRI plays a key role in identifying heart failure patients' response to cardiac resynchronization therapy. The identification of healthy myocardial regions for lead implantation is accomplished by means of late gadolinium enhancement MRI using exogenous contrast agents. Most MRI techniques that enable non-contrast cardiac tissue characterization are magnitude-based. MRI phase is an effective standalone source of information. However, most successful phase-based imaging is performed at lower field strength to alleviate field inhomogeneity-related artifacts. We present the application of a robust multiparametric magnitude- and phase-based myocardial mapping approach for scar tissue characterization at 3T.}
}
@inproceedings{ISMRM2018_4868,
annote={ISMRM2018_4868},
pages={4868},
file={ISMRM2018_4868.pdf:ISMRM2018_4868.pdf:PDF},
title={Temporal evaluation of acute myocardial ischemia/reperfusion injury in rats using 7.0T magnetic resonance imaging and {APT}102 therapeutic effect},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4868.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ziqian Xu and Jie Zheng and Fabao Gao},
abstract={Intramyocardial hemorrhage(IMH) and microvascualr obstruction(MVO) were the serious injuries in the early myocardial infarction reperfusion period, which were independent predictors of larger infarct size, lower systolic function and the worse prognosis at follow-up. APT102 as a synthetic apyrase of the hunman nucleoside triphosphate diphosphohydrolase-3(CD39L3) can exhibit ADPase activity, prevent thrombotic reocclusion and decrease infarct size without an increased bleeding risk. The purpose of this study was to continuously detect myocardial ischemia/reperfusion injury and APT102 effect in rats by 7.0T MRI.}
}
@inproceedings{ISMRM2018_4869,
annote={ISMRM2018_4869},
pages={4869},
file={ISMRM2018_4869.pdf:ISMRM2018_4869.pdf:PDF},
title={Estimation of late gadolinium enhancement of myocardial infarction with phase sensitive inversion recovery balanced steady state free precession ({PSIR}-b{SSFP})},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4869.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Takashige Yoshdia and Masami Yoneyama and Kohei Yuda and Takumi Koyano and Yuki Furukawa and Hiroe Kobayashi and Nobuo Kawauchi and Haruo Saito},
abstract={The late gallium enhancement (LGE) image showing an expression amount having a significant difference for improvement wall motion or not is estimated from contrast enhancement area in patients with cardiovascular disease. However, left ventricle blood (LVB) with contrast wash-out can have similar T1 value to scar and a fabrication sub-endocardial scar is often deluded as LVB. The phase sensitive inversion recovery balanced steady state free precession (PSIR-bSSFP) is possible to obtain black blood and contrast enhancement image. Our study of PSIR-bSSFP was propose BB-LGE that feasible visualize of myocardial hyper-enhancement area with LV blood suppression.}
}
@inproceedings{ISMRM2018_4870,
annote={ISMRM2018_4870},
pages={4870},
file={ISMRM2018_4870.pdf:ISMRM2018_4870.pdf:PDF},
title={Improvement of radiofrequency lesion visualization using 3D T1-weighted compressed sensing imaging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4870.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Pierre Bour and Valéry Ozenne and Marylène Delcey and Takeshi Kitamura and David Gonthier and Michaela Schmidt and Christoph Forman and Wadie Ben Hassen and Hubert Cochet and Pierre Jais and Bruno Quesson},
abstract={Visualization of acute radiofrequency lesions in the heart is a key point to assess the endpoint of catheter-based anti-arrhythmic therapy. Albeit 3D navigated T1-weighted sequences have proven there reliability to delineate lesion cores and edema, these sequences remain too lengthy/insufficiently spatially resolved to be used clinically. In this study we investigated the benefit of combining 3D T1-weighted acquisition with compressed sensing acceleration to reduce acquisition duration while maintaining sufficient spatial resolution to visualize the core of the lesion and surrounding edema. Methods are evaluated with/without gadolinium injection with different inversion times in vivo in the heart of swine.}
}
@inproceedings{ISMRM2018_4871,
annote={ISMRM2018_4871},
pages={4871},
file={ISMRM2018_4871.pdf:ISMRM2018_4871.pdf:PDF},
title={Accelerated free breathing 3D cardiac T1ρ mapping in humans using compressed sensing and improved k-space reordering},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4871.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Srikant Kamesh Iyer and Yuchi Han and Harold Litt and Walter R.T. Witschey},
abstract={Cardiac T1ρ MRI is a parametric mapping technique for imaging myocardial fibrosis and may benefit heart disease patients unable to receive contrast agents due to poor kidney function. The purpose of this work was to develop accelerated free-breathing T1ρ mapping MRI that achieves whole heart coverage with superior spatial resolution compared to 2D methods in a reasonable scan time using compressed sensing (CS). The overall hypothesis is that 3-fold accelerated free breathing 3D cardiac T1ρ MRI is feasible.}
}
@inproceedings{ISMRM2018_4872,
annote={ISMRM2018_4872},
pages={4872},
file={ISMRM2018_4872.pdf:ISMRM2018_4872.pdf:PDF},
title={3D Whole-Ventricle, Free-Breathing, Non-{ECG}, Myocardial T1 and {ECV} Mapping with {CMR} Multitasking},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4872.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jaime Shaw and Anthony Christodoulou and Xiaoming Bi and Debiao Li},
abstract={Myocardial fibrosis is a common pathological feature in cardiovascular diseases and can be detected with T1 and extracellular volume fraction (ECV) mapping. 3D methods are desirable to fully characterize the entire left ventricle. Typical T1 mapping methods require long scan times with respiratory navigators or repeated breath-holds which lead to patient discomfort or noncompliance. In this study, we perform 3D T1 and ECV mapping with CMR Multitasking to achieve whole-ventricle coverage in a free-breathing, non-ECG scan, producing comparable ECV to a conventional breath-hold, ECG-gated technique.}
}
@inproceedings{ISMRM2018_4873,
annote={ISMRM2018_4873},
pages={4873},
file={ISMRM2018_4873.pdf:ISMRM2018_4873.pdf:PDF},
title={Free-breathing and ungated 3D-T1rho mapping of the heart using golden angle radial sampling and compressed sensing with low-rank constrained sparse reconstruction},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4873.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Rajiv G Menon and Marcelo V.W. Zibetti and Azadeh Sharafi and Li Feng and Leon Axel and Ravinder R Regatte},
abstract={In this study, we present a technique for T1rho mapping of myocardium using a combination of T1rho preparation, radial sampling and low rank-based compressed sensing (CS) reconstruction. We acquire free-breathing, ungated data using a 3D T1rho prepared radial acquisition scheme with different spin lock times (TSL). After retrospectively synchronizing the data to a window in diastole, a sparse 3D k-dataset is given as input to compressed sensing reconstruction that uses a low rank constraint. Mono-exponential modeling of the reconstructed data yields the T1rho maps. The CS reconstruction results in improved images and the mean T1rho values estimated in the myocardium are consistent with literature.}
}
@inproceedings{ISMRM2018_4874,
annote={ISMRM2018_4874},
pages={4874},
file={ISMRM2018_4874.pdf:ISMRM2018_4874.pdf:PDF},
title={Myocardial fibrosis evaluated by diffusion weighted imaging and and its relationship to three-dimensional global contractile function in patients with hypertrophic cardiomyopathy},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4874.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Rui Wu and Dong-Ao-Lei An and Bing-Hua Chen and Ruo-Yang Shi and Wei-Bo Chen and Tong-Tong Han and Lian-Ming Wu and Jian-Rong Xu},
abstract={The prognostic value of the apparent diffusion coefficient (ADC) for diffuse myocardial fibrosis and its relationship to the contractile function is still not investigated. A total of 45 HCM patients and 20 controls underwent a 3.0-T cardiac magnetic resonance imaging (CMRI), including cine, T1 mapping and DWI. ADC values in the ECV ≥ 29.6\% group were significantly increased compared to the ECV < 29.6\% group. ADC values were linearly associated with 3D LV GCS, GLS, GCSR, GLSR and GRSR. Impairment of contractile function in HCM is predominantly associated with the contrast-free ADC value.}
}
@inproceedings{ISMRM2018_4875,
annote={ISMRM2018_4875},
pages={4875},
file={ISMRM2018_4875.pdf:ISMRM2018_4875.pdf:PDF},
title={Elevated {NT}-pro{BNP} in a Community Cohort is Associated with Myocardial Fibrosis: the Multi-Ethnic Study of Atherosclerosis ({MESA})},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4875.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Chia-Ying Liu and Susan R Heckbert and Shenghan Lai and Bharath Amable-Venkatesh and Mohammad R Ostovaneh and Robyn L McClelland and Joao A.C Lima and David A Bluemke},
abstract={We evaluated the relationship between cardiac MRI measures of fibrosis and NT-proBNP levels in 1334 participants in the Multi-Ethnic Study of Atherosclerosis (MESA). Univariate and multivariable regression analyses adjusting for demographics, cardiovascular risk factors and left ventricular (LV) mass were performed to examine the association of log NT-proBNP with MRI T1 mapping indices. In the fully adjusted model, each one standard deviation increment (0.44pg/mL) of log NT-proBNP was associated with 0.62\% increment in ECV (P<0.001), 4.7ms increment in native T1 (P=0.001) and 0.01 increment in partition coefficient (P<0.001). Elevated NT-proBNP is related to subclinical fibrosis in a community-based setting.}
}
@inproceedings{ISMRM2018_4876,
annote={ISMRM2018_4876},
pages={4876},
file={ISMRM2018_4876.pdf:ISMRM2018_4876.pdf:PDF},
title={Myocardial Oxygenation Using T2* {BOLD} Cardiac {MRI} with Compressed {SENSE}: Association with Myocardial Fibrosis and Contraction in Hypertrophic Cardiomyopathy},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4876.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Michinobu Nagao and Kenji Fukushima and Eri Watanabe and Umiko Ishizaki and Yuka Matsuo and Akiko Sakai and Risako Nakao and Yasuhiro Goto and Masami Yoneyama and Shuji Sakai},
abstract={We developed a new method for myocardial oxygenation using oxygen-inhalation blood-oxygen-level-dependent (BOLD) T2* cardiac magnetic resonance imaging (T2*-CMR). Myocardial oxygenation (ΔR2*, ms-1) was defined as the difference in R2* between under room-air and oxygen inhalation. ΔR2* is increased in patients with hypertrophic cardiomyopathy who had large LGE areas and low strains, suggesting that impairment of myocardial oxygenation associates with myocardial fibrosis and systolic dysfunction. In addition, T2*-CMR with compressed SENSE enables to shorten scan time and less motion artifact. This contributes to make high precision of T2* and R2* maps.}
}
@inproceedings{ISMRM2018_4877,
annote={ISMRM2018_4877},
pages={4877},
file={ISMRM2018_4877.pdf:ISMRM2018_4877.pdf:PDF},
title={Clinical validation of the T1blood-based synthetic hematocrit used to calculate the {ECV} on 3T {MRI} in patients with type 2 diabetes mellitus and hypertrophic cardiomyopathy},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4877.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Xiaoyue Zhou and Yongning Shang and Xiaochun Zhang and Jian Wang},
abstract={Calculation of the extracellular volume fraction is based on a patient’s hematocrit (Hct), which can be obtained via a clinical blood test or can be estimated synthetically according its linear relationship with the native T1 of the blood. However, the reliability of the synthetic Hct needs to be studied further. We therefore assessed the clinical validation of the synthetic Hct compared with the Hct derived from a blood test in patients with type 2 diabetes mellitus and hypertrophic cardiomyopathy.}
}
@inproceedings{ISMRM2018_4878,
annote={ISMRM2018_4878},
pages={4878},
file={ISMRM2018_4878.pdf:ISMRM2018_4878.pdf:PDF},
title={Free-Breathing Myocardial T1-Acquisition with Region-based Analysis is Feasible to Quantify Diffuse Myocardial Fibrosis},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4878.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Mao-Yuan Marine Su and Yu-Sen Huang and Yeun-Chung Chang and Shun-Chung Yang and Kui-Yuan Ho and Lian-Yu Lin and Cho-Kai Wu and Wen-Yih Isaac Tseng},
abstract={This study investigated whether free-breathing T1-acquisition with the proposed region-based (RB) method is feasible to quantify ECV as an index of diffuse myocardial fibrosis. Thirty-eight patients with non-ischemic cardiomyopathy (NICM) and 20 healthy controls were examined using both breath-hold and free-breathing myocardial T1-acquisitions. ECV was measured from free-breathing images by the RB method, which was compared with the measurement on the standard pixel-wise T1-mapping. Intraclass correlation coefficient of the two methods was 0.915. Patients with NICM showed significantly higher ECV than controls for both methods. Our results suggest that free-breathing T1-acquisition with the RB method is feasible to quantify diffuse myocardial fibrosis and is comparable to the measurement using the standard T1-mapping.}
}
@inproceedings{ISMRM2018_4879,
annote={ISMRM2018_4879},
pages={4879},
file={ISMRM2018_4879.pdf:ISMRM2018_4879.pdf:PDF},
title={Validation of Diffusion Tensor Imaging in Diseased Myocardium},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4879.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Irvin Teh and Darryl McClymont and Marie-Christine Zdora and Hannah J. Whittington and Katja Gehmlich and Christoph Rau and Craig A. Lygate and Jürgen E. Schneider},
abstract={Diffusion tensor imaging (DTI) has been used in clinical research to identify microstructural changes in the heart following disease. However, the evidence supporting its use in the presence of abnormalities such as scar, hypertrophy and collagen infiltration is limited. Here, we investigate the application of DTI in fixed healthy, infarcted, hypertrophic and fibrotic mouse hearts and validate these on a voxel-wise basis with high-resolution structure tensor synchrotron radiation imaging. Our findings show good agreement in helix angle estimation between the two imaging modalities across all hearts and supports the clinical role of DTI in the presence of cardiac pathologies.}
}
@inproceedings{ISMRM2018_4880,
annote={ISMRM2018_4880},
pages={4880},
file={ISMRM2018_4880.pdf:ISMRM2018_4880.pdf:PDF},
title={Feasibility Study of Whole Heart T1 Mapping with {SMS} in A Single Breath Hold},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4880.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Wenbo Sun and Meng Ye and Yuan Zheng and Lele Zhao and Nan Liu and Yanqun Teng and Lan Lan and Jian Xu and Haibo Xu},
abstract={A novel single breath hold (BH) whole-heart T1 mapping technique with simultaneous multi-slice (SMS) imaging with improved spatial coverage and faster acquisition speed is proposed and evaluated, the initial results show that the proposed whole heart T1 mapping approach has similar results compared to conventional approaches.}
}
@inproceedings{ISMRM2018_4881,
annote={ISMRM2018_4881},
pages={4881},
file={ISMRM2018_4881.pdf:ISMRM2018_4881.pdf:PDF},
title={Spin Echo Based Cardiac Diffusion Tensor Imaging of the Unfixed, Ex-vivo Porcine Heart at 7T and 3T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4881.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={David Lohr and Maxim Terekhov and Andreas Max Weng and Anja Schröder and Heike Walles and Laura Maria Schreiber},
abstract={7T, 3D, whole heart, high resolution, diffusion tensor data sets with 1.3mm isotropic voxels, unachievable in human in-vivo scans, were acquired for 8 ex-vivo pig hearts using a Stejskal-Tanner sequence with varying parallel imaging factors. ADC, FA, helix angle and secondary eigenvector angle values were analyzed and compared to a reference set of 26 ex-vivo hearts measured with the same protocol at 3T. Purpose of this study was quality assessment in DTI of the ex-vivo porcine heart at 7T. The proof of principle data acquired allows future optimization of acquisition approaches and helps translating the method to an in-vivo application.}
}
@inproceedings{ISMRM2018_4882,
annote={ISMRM2018_4882},
pages={4882},
file={ISMRM2018_4882.pdf:ISMRM2018_4882.pdf:PDF},
title={A myocardial strain phantom for cardiovascular magnetic resonance},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4882.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Andrew Scott and Priyanka Sukumaran and Pedro Ferreira and Jennifer Keegan and Sonia Nielles-Vallespin and Dudley Pennell and David Firmin},
abstract={We have developed a mechanical phantom which replicates myocardial strain in blocks of jelly and sections of myocardial tissue. Initial results show the effects of strain during the diffusion time in diffusion tensor cardiovascular magnetic resonance using STEAM and the use of the phantom evaluating the DENSE strain measurement technique.}
}
@inproceedings{ISMRM2018_4883,
annote={ISMRM2018_4883},
pages={4883},
file={ISMRM2018_4883.pdf:ISMRM2018_4883.pdf:PDF},
title={Native T1 Mapping for Characterization of Acute and Chronic Myocardial Infarction in Swine: Comparison with Contrast-enhanced {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4883.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Xi Liu and Zhi-gang Yang and Ying-kun Guo},
abstract={Native T1 mapping is a novel technique that permits quantification of the T1 relaxation time of myocardial tissue without requiring exogenous contrast agents, it could be used as a reliable alternative to LGE in patients with severe renal insufficiency. The present study was conducted to determine and verify the clinical feasibility of native T1 mapping of AMI and CMI as a replacement for LGE and for the discrimination of AMI from CMI in Bama mini-pigs. In our study, native T1 mapping can accurately determine acute and chronic infarct areas as well as conventional LGE imaging, however, it cannot distinguish acute from chronic myocardial infarction.}
}
@inproceedings{ISMRM2018_4884,
annote={ISMRM2018_4884},
pages={4884},
file={ISMRM2018_4884.pdf:ISMRM2018_4884.pdf:PDF},
title={Second-order motion-compensated in-vivo cardiac diffusion tensor imaging in diastole – impact of ventricular flow, strain and trigger delay.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4884.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Robbert J.H. van Gorkum and Constantin von Deuster and Christian T. Stoeck and Sebastian Kozerke},
abstract={Motion-compensated spin-echo cardiac diffusion tensor imaging (cDTI) sequences suffer from signal loss if the motion pattern has higher-order motion terms than the motion compensation model of the encoding gradients. Particularly cardiac strain, ventricular flow and atrial contraction render diffusion imaging in diastole challenging. It is shown that a suitable trigger delay in the diastolic phase can be identified by taking into account ventricular flow, strain and diffusion-weighted data at several time points in diastole. This knowledge aids towards the development of spin-echo-based cDTI sequences to study dynamic myofiber changes between systole and diastole.}
}
@inproceedings{ISMRM2018_4885,
annote={ISMRM2018_4885},
pages={4885},
file={ISMRM2018_4885.pdf:ISMRM2018_4885.pdf:PDF},
title={Prognostic value of cardiac T1 mapping in Pulmonary Arterial Hypertension},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4885.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Laura Saunders and Chris Johns and Neil Stewart and Charlotte Oram and David Capener and David Kiely and Martin Graves and Jim Wild and Andy Swift},
abstract={Native T1 mapping of the myocardium was performed in 223 patients with pulmonary arterial hypertension. Patients with higher right ventricular (RV) insertion point T1 were less likely to survive than patients with lower inter-ventricular insertion point T1, however when assessed in a multivariate Cox regression with other MRI markers of cardiac size and function, inter-ventricular insertion point T1 was not an independent predictor of mortality.}
}
@inproceedings{ISMRM2018_4886,
annote={ISMRM2018_4886},
pages={4886},
file={ISMRM2018_4886.pdf:ISMRM2018_4886.pdf:PDF},
title={Contrast steady state myocardial scar imaging in a chronic porcine infarct model},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4886.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={John Whitaker and Radhouene Neji and Rahul Mukherjee and James Harrison and Steven Williams and Henry Chubb and Louisa O'Neill and Justo Julia and John Silberbauer and Matthew Wright and Sébastien Roujol and Tevfik Ismail and Mark O'Neill and Reza Razavi},
abstract={Contrast steady state (CSS) may be achieved using continuous contrast infusion following bolus. This technique was used to acquire high resolution late gadolinium enhanced (LGE) scar imaging of 8 pigs with chronic myocardial infarction. CSS imaging allowed extended acquisition to facilitate high-resolution 3D LGE imaging with improved signal-to-noise, contrast-to-noise and overall image quality. CSS may also be used in experimental studies, when total gadolinium bolus is not restricted, to directly compare imaging sequences acquired using consistent contrast distributions.}
}
@inproceedings{ISMRM2018_4887,
annote={ISMRM2018_4887},
pages={4887},
file={ISMRM2018_4887.pdf:ISMRM2018_4887.pdf:PDF},
title={An off-resonance correction for in-vivo spiral {STEAM} diffusion tensor cardiovascular magnetic resonance},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4887.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Margarita Gorodezky and Andrew Scott and Pedro F Ferreira and Sonia Nielles-Vallespin and Dudley J Pennell and David N Firmin},
abstract={Spiral diffusion tensor cardiovascular magnetic resonance demonstrates promising results, but as with all spiral techniques is susceptible to off-resonance artefacts. The majority of off-resonance corrections rely on acquiring a separate field map based on phase differences between acquisitions with different echo times. However, bulk motion is encoded in image phase using STEAM and the motion and off-resonance induced phases are indistinguishable. Here we use a dual spiral approach in each stimulated echo to separate the motion- and off-resonance-induced phase and use this information to correct DT-CMR data.}
}
@inproceedings{ISMRM2018_4888,
annote={ISMRM2018_4888},
pages={4888},
file={ISMRM2018_4888.pdf:ISMRM2018_4888.pdf:PDF},
title={Assessment of Myocardial Fibrosis in Uremic Cardiomyopathy using Cardiac {MR} Native T1 Mapping: A Comparison with Coronary Artery Calcium Score},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4888.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Shengjia Gu and Wenjie Yang},
abstract={Congestive heart failure is the leading cause of death in patients with end-stage renal disease. The process of this type of dysfunction is termed uremic cardiomyopathy. Extensive myocardial fibrosis, which leads the process, has also been shown to be a stronger predictor of death. Recently, anti-fibrosis has risen as a hot target in the treatment of uremic cardiomyopathy. Therefore, its urgent to find a more accurate and non-invasive method in order to meet the demand of clinic.In this study, we use the native T1 mapping to assess the level of myocardial fibrosis in ESRD patients,comparing with the Coronary Artery Calcium Score, in order to evaluate its accuracy in diagnosis uremic cardiomyopathy.}
}
@inproceedings{ISMRM2018_4889,
annote={ISMRM2018_4889},
pages={4889},
file={ISMRM2018_4889.pdf:ISMRM2018_4889.pdf:PDF},
title={Expanding {SMS} cardiac imaging with deep slice interpolation},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4889.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Eric Gibbons and Akshay Chaudhari and Edward DiBella},
abstract={Cardiac SMS imaging acquires multiple slices at the same time as a single slice. SMS provides increased slice coverage without a loss in temporal resolution, which is important in myocardial perfusion imaging. However, a single SMS acquisition is able to acquire three slices at a time, which is insufficient for whole heart coverage. This work expands SMS coverage by using new deep learning interpolation techniques to generate missing slices in the "gaps" between acquired slices in SMS imaging.}
}
@inproceedings{ISMRM2018_4890,
annote={ISMRM2018_4890},
pages={4890},
file={ISMRM2018_4890.pdf:ISMRM2018_4890.pdf:PDF},
title={Contrast-free 3D whole-heart magnetization transfer imaging for simultaneous myocardial scar and cardiac vein visualization},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4890.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Karina Lopez and Radhouene Neji and Rahul Mukherjee and Imran Rashid and Reza Razavi and Claudia Prieto and Sebastien Roujol and Rene Botnar},
abstract={A novel 3D contrast-free and motion corrected sequence for simultaneous assessment of chronic myocardial scar and coronary veins is proposed, using magnetization transfer ratio (MTR) to target the increase in collagen content associated with fibrosis. Two gradient echo datasets are sequentially acquired to obtain MTR: a reference and an off-resonance MT-weighted image. Bloch simulations and in-vivo data demonstrated that the proposed acquisition is superior to bSSFP MT-weighted sequences, yielding more consistent MTR values throughout the myocardium. Scans in patients with chronic scar confirmed the ability of MTR to localize scar, in addition to cardiac vein visualization from the MT-weighted image.
}
}
@inproceedings{ISMRM2018_4891,
annote={ISMRM2018_4891},
pages={4891},
file={ISMRM2018_4891.pdf:ISMRM2018_4891.pdf:PDF},
title={A comparison of motion compensated spin echo (M2{SE}) and stimulated echo acquisition mode ({STEAM}) diffusion tensor cardiovascular magnetic resonance in the in vivo assessment of hypertrophic cardiomyopathy.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4891.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Zohya Khalique and Andrew Scott and Pedro Ferreira and Sonia Nielles-Vallespin and David Firmin and Dudley Pennell},
abstract={Diffusion tensor cardiovascular magnetic resonance (DT-CMR) interrogates myocardial microstructure, using parameters such as mean diffusivity (MD), fractional anisotropy (FA) and secondary eigenvector angulation (E2A), an index of sheetlet orientation. We compared motion compensated spin echo (M2SE) and stimulated echo acquisition mode (STEAM) and their ability to distinguish hypertrophied fibrosed myocardium (LVH+Gd+) in hypertrophic cardiomyopathy. M2SE discriminated areas of LVH+Gd+ best through FA and MD, whilst STEAM was more sensitive to changes in E2A mobility. FA derived from both M2SE and STEAM correlated significantly with extracellular volume.}
}
@inproceedings{ISMRM2018_4892,
annote={ISMRM2018_4892},
pages={4892},
file={ISMRM2018_4892.pdf:ISMRM2018_4892.pdf:PDF},
title={Analysis of cardiac motion induced error for in-vivo cardiac {DTI} in different heart phases - a comparison of second-order motion compensated {SE} versus {STEAM}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4892.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Christian T Stoeck and Constantin von Deuster and Robbert J H van Gorkum and Sebastian Kozerke},
abstract={Being a single R-R interval imaging technique, second order motion compensated spin echo (M2-SE) cardiac DTI is appealing for clinical application but its implementation has so far been limited to systolic imaging. In this study we investigate signal dephasing in in-vivo cDTI at different time points within the cardiac cycle. The motion induced dephasing found for both sequences lies well within the previously reported limits for repeated measurements, when imaged in mid-to-end systole and diastole. STEAM based approaches result in consistent signal preservation across the cardia cycle, while M2-SE the exhibits a minimum in signal dephasing at around 50\%-75\% systole.}
}
@inproceedings{ISMRM2018_4893,
annote={ISMRM2018_4893},
pages={4893},
file={ISMRM2018_4893.pdf:ISMRM2018_4893.pdf:PDF},
title={3D Radial Free-breathing Variable Flip Angle Whole Heart Myocardial T1 Mapping},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4893.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Orhan Unal and Steve Kecskemeti},
abstract={A number of quantitative T1 mapping techniques have been developed for assessing myocardial pathologies. Inversion recovery (IR) techniques such as MOLLI are widely used due to higher precision and better reproducibility but tend to underestimate T1 values. The aim of this study was to evaluate the potential of new, free-breathing, variable flip angle (VFA), 3D radial and 3D hybrid-radial-Cartesian IR techniques accelerated using radial k-space undersampling for myocardial T1 quantification. Our initial results show promise and suggest that the proposed 3D T1 mapping techniques are not sensitive to B1 variations.}
}
@inproceedings{ISMRM2018_4894,
annote={ISMRM2018_4894},
pages={4894},
file={ISMRM2018_4894.pdf:ISMRM2018_4894.pdf:PDF},
title={Reconstructing real-time exercise stress cine images with multiple sets of sensitivity maps},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4894.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Chong Chen and Yingmin Liu and Orlando Simonetti and Rizwan Ahmad},
abstract={Motivated by the changing sensitivity maps due to exaggerated chest wall motion in real-time stress cardiac MRI (CMR), we utilize ESPIRiT-based multiple sets of sensitivity maps in a SENSE-based reconstruction method to reduce image artifact. The proposed method was tested on twelve volunteers and compared with the images reconstructed using a temporally invariant single set of sensitivity maps as well as a temporally varying single set of sensitivity maps. It was demonstrated that using multiple sets of sensitivity maps leads to significant reduction in image artifact.}
}
@inproceedings{ISMRM2018_4895,
annote={ISMRM2018_4895},
pages={4895},
file={ISMRM2018_4895.pdf:ISMRM2018_4895.pdf:PDF},
title={Accelerated, 3D Cine {MRI} with Stack of Stars k-space Sampling and Self-Navigation of Respiratory Motion for Aortic Valve Visualization.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4895.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Nivedita Naresh and Hassan Haji-Valizadeh and Bradley D. Allen and Matthew J. Barrett and Daniel C. Lee and Jeremy D. Collins and James C. Carr and Daniel Kim},
abstract={Aortic valve disease is the most common form of valvular heart disease in the western world and accurate aortic valve visualization is very important for this reason. Accurate imaging of the aortic valve is very critical in grading and diagnosing the severity of the disease. 3D imaging may enable better visualization of the aortic valve as compared to the standard 2D techniques due to both the ability to acquire high resolution volumetric coverage and to visualize in other imaging planes. This study describes the development and evaluation of an accelerated, 3D cine MRI pulse sequence using a combination of stack-of-star k-space sampling and XDGRASP reconstruction.}
}
@inproceedings{ISMRM2018_4896,
annote={ISMRM2018_4896},
pages={4896},
file={ISMRM2018_4896.pdf:ISMRM2018_4896.pdf:PDF},
title={Influence of respiration-induced B0 variations in {CSF} flow quantification},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4896.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Kristina Peters and René Bastkowski and Kilian Weiss and David Maintz and Daniel Giese},
abstract={Susceptibility changes and resulting B
0 changes during the respiratory cycle lead to phase variations in cerebrospinal fluid phase-contrast flow measurements and might be erroneously misinterpreted as physiological flow changes. These B
0 changes were analysed by acquiring flow compensated and flow encoded real-time, single-shot EPI images. The respiration-induced phase variations in phase-contrast images were found to depend on the magnetic field strength, the delay between the flow compensated and flow encoded images and the depth and frequency of respiration. Thus, respiration-induced B
0 variations need to be corrected prior to analysing true respiration-dependent cerebrospinal fluid flow measured by real-time phase-contrast MRI.}
}
@inproceedings{ISMRM2018_4897,
annote={ISMRM2018_4897},
pages={4897},
file={ISMRM2018_4897.pdf:ISMRM2018_4897.pdf:PDF},
title={Self-gated respiratory-resolved 5D Flow {MRI} using the 3D spiral phyllotaxis trajectory},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4897.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Monica Sigovan and Gastao Cruz and Torben Schneider and Juan Felipe Perez-Juste Abascal and Cyril Mory and Guruprasad Krishnamoorty and Rene Botnar and Philippe Douek and Claudia Prieto and Loic Boussel},
abstract={Clinical diagnosis based on thoracic blood flow using three-dimensional cardiac-resolved (4D) phase contrast PC-MRI is limited by long acquisition times, due to the need of respiratory gating. In addition, gating does not provide potentially important physiological information, the variation of flow within the respiratory cycle. To address these challenges we developed a 5D (4D respiratory-resolved) PC-MRI sequence combining 3D radial k-space sampling, respiratory self-gating and compressed sensing reconstruction. Our preliminary results demonstrate respiratory related changes in blood flow in healthy subjects. The proposed method may potentially refine diagnosis in congenital heart disease by assessing the respiratory related blood flow variations.}
}
@inproceedings{ISMRM2018_4898,
annote={ISMRM2018_4898},
pages={4898},
file={ISMRM2018_4898.pdf:ISMRM2018_4898.pdf:PDF},
title={Dynamic Auto-calibrated Multiband {CAIPIRINHA}: proof of principle and application to cardiac tissue phase mapping},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4898.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Giulio Ferrazzi and Jean Pierre Bassenge and Clarissa Wink and Johannes Mayer and Anthony N. Price and Steen Moeller and Pierre-François Van de Moortele and Alexander Ruh and Michael Markl and Sebastian Schmitter},
abstract={In conventional multiband CAIPIRINHA, an additional reference scan is acquired to allow the separation of the simultaneously excited slices. In this study, an acquisition-reconstruction method that makes use of the multiband data itself to calculate this reference scan is presented. The immediate implication is that the full multiband acceleration can be exploited. In addition, since the reference data has the same resolution and phase structure to multiband (i.e. it is the same data), improved slice separation is achieved. The method was implemented starting from a 2D CINE phase-contrast MR sequence and it was used to assess velocities in the myocardium in two subjects scanned at 3T.}
}
@inproceedings{ISMRM2018_4899,
annote={ISMRM2018_4899},
pages={4899},
file={ISMRM2018_4899.pdf:ISMRM2018_4899.pdf:PDF},
title={Real life application of compressed sensing cardiac {MRI} for biventricular response to exercise.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4899.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Aaron Lin and Norman Morris and Helen Seale and Andrew Trotter and Benjamin Schmitt and Wendy Strugnell},
abstract={Accurate assessment of left and right ventricular function using cardiac MRI plays an important role in the management of cardiac diseases. Combined with exercise stress testing, unveiling of cardiac diseases in the latent phase permits early initiation of appropriate therapy. Using compressed sensing cardiac MRI, we demonstrated dynamic quantitative biventricular functional assessment is safe and highly feasible for clinical utility.}
}
@inproceedings{ISMRM2018_4900,
annote={ISMRM2018_4900},
pages={4900},
file={ISMRM2018_4900.pdf:ISMRM2018_4900.pdf:PDF},
title={One Minute Free Breathing 3D Cardiac Cine {MRI} Using Data Clustering for Respiratory Self-Gating with Subject-Adaptive Gating Efficiency},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4900.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jing Liu and Peng Lai and Yan Wang and Zhaoying Wen and Karen Ordovas},
abstract={Conventional 2D cine MRI for cardiac functional measurements requires a series of breath-holds, which is usually difficult for children or sick patients and often results in non-diagnostic images. We aim to develop a fast and reliable free-breathing 3D imaging technique, which also allows subject-specific respiratory motion compensation.}
}
@inproceedings{ISMRM2018_4901,
annote={ISMRM2018_4901},
pages={4901},
file={ISMRM2018_4901.pdf:ISMRM2018_4901.pdf:PDF},
title={3D myocardial t1 mapping using a 2D fat image navigator for respiratory motion correction},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4901.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Giovanna Nordio and Torben Schneider and Gastao Cruz and Teresa Correia and Claudia Prieto and Rene Botnar and Markus Henningsson},
abstract={In this study, we propose a 3D whole-heart saturation-recovery T1-mapping technique combined with a 2D fat image navigator (fat-iNAV) for respiratory motion compensation. Respiratory motion of the heart is estimated from the 2D fat-iNAVs and used to correct the T1-weighted images prior to the fitting. The delineation of the myocardium is considerably improved after motion correction, while gating permits to further improve image quality and precision (p<0.05) of the T1 maps. Future work will focus on validating the proposed technique on patients with cardiovascular disease.}
}
@inproceedings{ISMRM2018_4902,
annote={ISMRM2018_4902},
pages={4902},
file={ISMRM2018_4902.pdf:ISMRM2018_4902.pdf:PDF},
title={Motion Correction for 3D+time Cardiac {MRI} Perfusion Images},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4902.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Apoorva Shirish Pedgaonkar and Ye Tian and Jason Mendes and Ganesh Adluru and Edward DiBella},
abstract={A motion correction technique for 3D dynamic cardiac perfusion MRI using rigid and non-rigid image registrations to improve quantification of cardiac perfusion is presented. This method is unique because it employs a 3D image registration which not only resolves in plane motion but also resolves the out of plane motion for all slices in a 3D volume. This method also ensures smooth registration between all time frames of the data giving a more accurate analysis of the flow values.}
}
@inproceedings{ISMRM2018_4903,
annote={ISMRM2018_4903},
pages={4903},
file={ISMRM2018_4903.pdf:ISMRM2018_4903.pdf:PDF},
title={Propagation of Metaplastic Adipose Tissue Throughout the Scar of Hemorrhagic Myocardial Infarct is an Iron-Dependent Process: Cardiac {MRI} Study with Histological Insights},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4903.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ivan Cokic and Guan Wang and Xingmin Guan and Hsin-Jung Yang and Richard LQ Tang and Diego Hernando and Scott B Reeder and Rohan Dharmakumar},
abstract={Lipomatous metaplasia (LM) of myocardial infarctions (MI) is typically observed in the peripheral zone of chronic MI and has been linked to major adverse clinical outcomes. To date, the mechanisms driving LM of MI remain unknown. A common feature of many disease processes associated with pathological fat accumulation is the iron-induced foam cell formation. Growing body of evidence now shows that iron deposits within hemorrhagic MI drive the prolonged recruitment of phagocytes into the infarcted territory. Herein, we investigated the spatial distribution and temporal accumulation of fatty infiltration in hemorrhagic MIs.}
}
@inproceedings{ISMRM2018_4904,
annote={ISMRM2018_4904},
pages={4904},
file={ISMRM2018_4904.pdf:ISMRM2018_4904.pdf:PDF},
title={Simultaneous T1 and T2 Mapping of the Carotid Artery with T2 and Inversion Recovery Prepared 3D Radial Imaging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4904.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Haikun Qi and Jie Sun and Huiyu Qiao and Rui Guo and Xihai Zhao and Niranjan Balu and Zechen Zhou and Chun Yuan and Huijun Chen},
abstract={Multi-contrast MRI has been widely used for comprehensive characterization of atherosclerotic plaque. However, the qualitative nature and long scan time have limited its clinical application. In this study, a 3D high spatial resolution time-efficient technique, iGOAL-SNAP, is proposed, which generates different T1 and T2 contrasts in a single scan of 8min, enabling simultaneous T1 and T2 mapping. In addition, a rapid B1 correction method is presented in the fitting process. The accuracy and feasibility of iGOAL-SNAP was demonstrated using phantoms and in vivo studies.}
}
@inproceedings{ISMRM2018_4905,
annote={ISMRM2018_4905},
pages={4905},
file={ISMRM2018_4905.pdf:ISMRM2018_4905.pdf:PDF},
title={Cardiac and Respiratory Self-Gated Motion-Corrected Free-Breathing Spiral Cine Imaging.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4905.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ruixi Zhou and Yang Yang and Roshin Mathew and Michael Salerno},
abstract={We developed a free-breathing continuous-acquisition respiratory and cardiac self-gated spiral cine pulse sequence. Data was acquired using a single spiral interleaf rotated by the golden-angle in time. The cardiac self-gating signal was extracted using principal component analysis on a gridded 8x8 central region of k-space for each spiral and the respiratory motion is derived from rigid registration for each heartbeat. Images were reconstructed with motion compensated SPIRiT using 16 seconds (2000 spirals) or 8 seconds of data. Free-breathing self-gated spiral cine imaging demonstrated high image quality providing whole heart coverage with clinical spatial and temporal resolution in under 3 minutes.}
}
@inproceedings{ISMRM2018_4906,
annote={ISMRM2018_4906},
pages={4906},
file={ISMRM2018_4906.pdf:ISMRM2018_4906.pdf:PDF},
title={Navigator-less manifold recovery of cardiac data using iterative {ST}o{RM}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4906.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yasir Q Mohsin and Sunrita Poddar and Bijoy Thattayilath and Deidra Ansah and Mathews Jacob},
abstract={Self-gated acquisitions, which rely on navigator acquisitions, can offer shortened scan time and can enable cardiac imaging of patients who cannot hold their breath; they are emerging as promising alternatives to breath-held protocols. A challenge with such schemes is the inefficiencies associated with the navigator acquisition, as well as the need for complex and heuristic processing of the navigator signals to accurately determine the cardiac and respiratory phases. The focus of this work is to introduce a navigator-less acquisition and reconstruction strategy, built upon our recent work termed as SToRM, which exploits the manifold structure of images. The proposed framework eliminates the need for navigators in SToRM, in addition to enabling spatially localized manifold modeling, where the manifold structure can vary depending on the spatial structure.}
}
@inproceedings{ISMRM2018_4907,
annote={ISMRM2018_4907},
pages={4907},
file={ISMRM2018_4907.pdf:ISMRM2018_4907.pdf:PDF},
title={Initial Validation of Free-Breathing Navigator Gated Cardiac Quantitative Susceptibility Mapping via Comparison with Right Heart Catheterization Measurements},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4907.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yan Wen and Thanh Nguyen and Pascal Spincemaille and Zhe Liu and Javid Alakbarli and Jiwon Kim and Evelyn M. Horn and Meridith P. Pollie and Jonathan W. Weinsaft and Yi Wang},
abstract={Our previous work has shown the feasibility of measuring differential RV-to-LV oxygen saturation with cardiac quantitative susceptibility mapping (QSM) in healthy volunteers; in this work, we present our initial validation of cardiac QSM in patients by comparing the QSM-based measurements with gold standard right heart catheter measurements.}
}
@inproceedings{ISMRM2018_4908,
annote={ISMRM2018_4908},
pages={4908},
file={ISMRM2018_4908.pdf:ISMRM2018_4908.pdf:PDF},
title={Reduced Specific Energy Deposition with Diagnostic Image Quality in Pediatric Population using {CA}rdio{RE}spiratory Synchronized ({CARES}ync) Balanced Steady-State Free Precession Cine Imaging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4908.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Amol S. Pednekar and Siddharth Jadhav and Ivone Rodriguez and Connor Ho and Cory Noel and Prakash Masand},
abstract={Cine-bSSFP cardiac imaging in sedated pediatric population faces two-fold challenges: 1) respiratory motion; and 2) cardiocirculatory impairment associated compromised thermoregulatory response. Prospective 63 sedated patients’ study shows that CAdioREspiratory Synchronized sequence, with prospective arrhythmia rejection and retrospective cardiac gating, reduced specific absorbed energy per slice in fixed (18.96±5.16 J/kg) by 49.36\% and adaptive (24.13±9.55 J/kg) by 39.24\% modes, than equivalent 4NSA sequence while maintaining spatial, temporal and contrast resolutions possible with breath-holds, providing consistently good image quality with 21.13\% increased scan time (26.38±8.15 s) per slice. Adaptive mode reduced scan time by 18\% than fixed mode for favorable cardiorespiratory rates.}
}
@inproceedings{ISMRM2018_4909,
annote={ISMRM2018_4909},
pages={4909},
file={ISMRM2018_4909.pdf:ISMRM2018_4909.pdf:PDF},
title={{MRI}-based retrospective gating for {PET} reconstruction in rats: implementation and proof of principle study},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4909.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Willy Gsell and Uwe Himmelreich and Arno Nauerth and Cesar Molinos and Carlos Correcher and Antonio J Gonzalez and Sven Junge and Thorsten Greeb and Ramiro Polo and Bryan Holvoet and Christophe M Deroose and Michael Heidenreich},
abstract={We hereby report the implementation and the preliminary results of an MRI-based retrospective gating strategy for reconstructing simultaneously acquired PET data in rats (SPECMRI). Ejection fraction extracted from MRI, SPECMRI and ECG-gated PET were all within the same range (70.0 ± 3.5\%, 72.5 ± 5.4\% and 70.5 ±6\% for MRI, ECG-gated and SPECMRI respectively). This new technique enables to ease the animal handling (no need for ECG electrodes) and provide true synchronization of PET and MRI data.}
}
@inproceedings{ISMRM2018_4910,
annote={ISMRM2018_4910},
pages={4910},
file={ISMRM2018_4910.pdf:ISMRM2018_4910.pdf:PDF},
title={Assessment of right ventricular functional recovery after acute myocardial infarction by cardiac magnetic resonance},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4910.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yue Gao and Zhigang Yang and Min Ma and Kaiyue Diao and Qin Zhao and Yong He},
abstract={In order to clarify the assess the right ventricular (RV) function changes and recovery and the relationship with different culprit vessel for myocardial infarction (MI) patients on cardiac magnetic resonance (CMR). We prospectively recruited forty-nine MI patients and 20 healthy control, all them underwent CMR to analysis right ventricular (RV) function and global strain. Our results showed that, the RV function was related to whether the culprit vessel was RCA or not and even RCA was obstructed the RV global strain can significantly recovery at chronic phase.}
}
@inproceedings{ISMRM2018_4911,
annote={ISMRM2018_4911},
pages={4911},
file={ISMRM2018_4911.pdf:ISMRM2018_4911.pdf:PDF},
title={Simultaneous multislice spiral cine {DENSE} {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4911.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Changyu Sun and Yang Yang and Xiaoying Cai and Sophia Cui and Daniel Auger and Michael Salerno and Frederick H. Epstein},
abstract={Spiral cine DENSE is an established method for imaging myocardial strain, however a relatively long acquisition time is a limitation. We developed a simultaneous multislice (SMS) method to accelerate spiral cine DENSE imaging. For SMS excitation we employed CAIPIRINHA phase modulation of the multiple slices. For the SMS reconstruction, we implemented a modified iterative conjugate gradient sensitivity encoding (CG-SENSE) method. Simulations and experiments in phantoms show that a 10-15\% error occurs when imaging two slices simultaneously. Two-slice volunteer SMS images showed close agreement with separately-acquired single-slice images. SMS with CG-SENSE may be an effective means to accelerate spiral cine DENSE.}
}
@inproceedings{ISMRM2018_4912,
annote={ISMRM2018_4912},
pages={4912},
file={ISMRM2018_4912.pdf:ISMRM2018_4912.pdf:PDF},
title={Effects of sex and age on {CMR}-derived left ventricular wall thickness and peak systolic wall stress in normal subjects},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4912.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Xiaodan Zhao and Angela S Koh and Soo Kng Teo and Sen Lin and Shuang Leng and Ris Low and Yi Su and Ru San Tan and Liang Zhong},
abstract={To investigate the left ventricular (LV) wall thickness, LV wall stress and their association with age and sex in a cohort of 210 healthy subjects (age: 19 to 87 years), endocardial and epicardial contour meshes from stacks of 2D short axis images were imported into our in-house software (CardioWerkz) for further analysis of 3D regional wall thickness and peak systolic wall stress (PSWS). Results indicated that mean LV wall thickness was smaller in females than males and more positively correlated with age in female than male. Moreover, no significant difference for mean PSWS between females and males.}
}
@inproceedings{ISMRM2018_4913,
annote={ISMRM2018_4913},
pages={4913},
file={ISMRM2018_4913.pdf:ISMRM2018_4913.pdf:PDF},
title={Model-Based Lag Free Processing of Pilot Tone Navigator Data Enables Prospective Cardiac Triggering},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4913.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Mario Bacher and Peter Speier and Jan Bollenbeck and Matthias Fenchel and Matthias Stuber},
abstract={Cardiac MRI acquisitions require accurate triggering, usually derived from ECG. The contactless, electromagnetic Pilot Tone navigator enables direct measurement of cardiac and respiratory motion, independently of the acquisition. Here we present an almost lag free pipeline to process the cardiac Pilot Tone signal and derive triggers from it.}
}
@inproceedings{ISMRM2018_4914,
annote={ISMRM2018_4914},
pages={4914},
file={ISMRM2018_4914.pdf:ISMRM2018_4914.pdf:PDF},
title={k-t2 {ESPIR}iT – Image reconstruction of respiratory motion resolved undersampled 4D Flow {MRI} data in a higher-dimensional subspace},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4914.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jonas Walheim and Claudio Santelli and Sebastian Kozerke},
abstract={An image reconstruction algorithm termed k-t2 ESPIRiT is proposed, which constrains respiratory motion-resolved MRI to a high-dimensional subspace spanned by receiver-coil channels, cardiac phases and respiratory motion states. Respiratory motion resolved 4D flow MRI data is reconstructed and compared to k-t ESPIRiT reconstruction of end-expiration and a standard parallel imaging protocol. Increased reconstruction accuracy compared to k-t ESPIRiT reveals that k-t2 ESPIRiT can effectively exploit redundancies between respiratory motion states to improve scan efficiency.
}
}
@inproceedings{ISMRM2018_4915,
annote={ISMRM2018_4915},
pages={4915},
file={ISMRM2018_4915.pdf:ISMRM2018_4915.pdf:PDF},
title={Pulsatility and velocity in cerebral penetrating arteries in patients with carotid occlusive disease with 7T phase contrast: preliminary results},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4915.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Tine Arts and Laurien Onkenhout and Jeroen Siero and Jaco Zwanenburg and Geert Jan Biessels},
abstract={The direct contribution of hemodynamics to the development and progression of vascular cognitive impairment (VCI) is relatively unexplored due to technical challenges concerning the assessment of hemodynamic properties of small vessels. This ongoing study explores changes of hemodynamics by measuring the velocity and pulsatility of perforating arteries in patients with internal carotid artery disease and healthy controls. The preliminary results indicate that high resolution velocity and pulsatility measurements in patients are challenging, particularly due to motion related artefacts. Thus, future research will evaluate user independent analysis to reduce the influence of artifacts and assess test-retest agreement by repeated scanning.}
}
@inproceedings{ISMRM2018_4916,
annote={ISMRM2018_4916},
pages={4916},
file={ISMRM2018_4916.pdf:ISMRM2018_4916.pdf:PDF},
title={{INVESTIGATION} {OF} {CEREBRAL} {BLOOD} {FLOW} {PULSATILITY} {IN} {AGING} {PROCESS} {USING} {PHASE} {CONTRAST} {MAGNETIC} {RESONANCE} {IMAGING}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4916.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Armelle LOKOSSOU and Bader CHAARANI and Souraya ELSANKARI and Catherine GONDRY-JOUET and Olivier BALEDENT},
abstract={No study already evaluated how arterial blood flow is transferred from extracranial to intracranial level and how venous outflow is transferred from intracranial sinuses to jugular veins. Healthy young and elderly volunteers were enrolled and underwent phase contrast magnetic resonance imaging to investigate intracranial and extracranial arterial and venous flows. In both groups, we found a significant decrease of arterial and venous flows pulsatilities inside the cranium. However, the intracranial and extracranial cerebral blood flow pulsatilities increased significantly with age.}
}
@inproceedings{ISMRM2018_4917,
annote={ISMRM2018_4917},
pages={4917},
file={ISMRM2018_4917.pdf:ISMRM2018_4917.pdf:PDF},
title={Quantification of total cerebral blood flow measurements using phase contrast magnetic resonance imaging: Comparison and validation at 1.5T and 3T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4917.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yen-Chih Huang and Chun-Ming Chen and Shin-Lei Peng},
abstract={The effect of field strengths of the total cerebral blood flow (TCBF) quantification using non-gated phase contrast magnetic resonance imaging (PC-MRI) was evaluated in this study. Our results show that, non-gated PC-MRI for TCBF quantification at 3T provided better inter-scan reproducibility when compared to that at 1.5T. Nevertheless, non-gated PC-MRI for TCBF measurements can be performed equally well at 1.5T and 3T. Findings of this study may facilitate data interpretation and comparison of TCBF between different field strengths.}
}
@inproceedings{ISMRM2018_4918,
annote={ISMRM2018_4918},
pages={4918},
file={ISMRM2018_4918.pdf:ISMRM2018_4918.pdf:PDF},
title={4D {CSF} Flow Measurement in Cervical Spine at 3T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4918.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ruponti Nath and MJ Negahdar and Robert Bert and Amir Amini},
abstract={Quantitative and Qualitative analysis of CSF flow was done on a Siemens Skyra 3T Scanner. Four normal Volunteers data shows highly accurate flow waveform, average distance travelled by particle along spinal axis and clear axial and coronal flow visualization between C3-C6 in the cervical spine. Particle tracking was performed in each axial slices. Distance travelled by particles along spinal axis was measured in all volunteers. The average distance travelled in all slices during systole in the head to foot direction varied from 0.1mm to 0.38 mm and during diastole varied from 0.14mm to 0.28 mm in the opposite directions.}
}
@inproceedings{ISMRM2018_4919,
annote={ISMRM2018_4919},
pages={4919},
file={ISMRM2018_4919.pdf:ISMRM2018_4919.pdf:PDF},
title={Pseudo spiral sampling and Compressed Sensing reconstruction provides high acceleration of intracranial 4D flow {MRI} at 7T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4919.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Lukas M. Gottwald and Johannes Töger and Eva S. Peper and Karin Markenroth Bloch and Qinwei Zhang and Bram F. Coolen and Gustav J. Strijkers and Pim van Ooij and Aart J. Nederveen},
abstract={Long scan times limit the application of 4D flow in clinical practice. Even at 7T, considerable scan times are needed for modest spatiotemporal resolutions. This work demonstrates the advantage of Compressed Sensing acceleration of 4D flow MRI at 7T with a novel undersampling technique. Healthy subjects (n=5) were scanned using standard SENSE and a proposed undersampling technique with Compressed Sensing reconstruction. Flow analysis showed minor differences and image quality improved for Compressed Sensing reconstructions with maintained resolution and reduced scan time. The method enables further increases of acceleration and spatiotemporal resolution, adding more physiological details beyond current resolution limitations.}
}
@inproceedings{ISMRM2018_4920,
annote={ISMRM2018_4920},
pages={4920},
file={ISMRM2018_4920.pdf:ISMRM2018_4920.pdf:PDF},
title={Influence of Signal Magnitude on Intracranial Flow Quantification using 4D flow {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4920.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Leonardo A Rivera-Rivera and Tilman Schubert and Patrick A Turski and Oliver Wieben and Kevin M Johnson},
abstract={Physiological parameters derived from quantitative flow MRI can potentially improve characterization of a large spectrum of vascular diseases if routinely used in a clinical setting. However, current barriers limit the use of quantitative flow MRI in a clinical setting, partially due to a lack of calibration tests and concerns regarding accuracy and reproducibility. In this study we investigate the potential induced bias of flow measurements in a cranial 4D flow MRI acquisition due to signal magnitude heterogeneity and the implications for comparing protocols with differing flip angle or contrast agent usage.}
}
@inproceedings{ISMRM2018_4921,
annote={ISMRM2018_4921},
pages={4921},
file={ISMRM2018_4921.pdf:ISMRM2018_4921.pdf:PDF},
title={Blood Brain Barrier Water Permeability in Non-Enhancing Multiple Sclerosis Lesion with Intrinsic Diffusivity Encoding of Arterial Labeled Spins ({IDEALS})},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4921.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Kenneth T Wengler and Jason Ha and Patricia Coyle and Mark Schweitzer and Tim Q Duong and Xiang He},
abstract={Persistent endothelial abnormalities and blood-brain barrier (BBB) disruption may play an important role in MS lesion formation and progression. In MS, BBB dysfunction occurs not only in active lesions with contrast-enhancement, but also in inactive (chronic) lesions and normal appearing white matter. In this study a novel method to map whole-brain BBB water permeability (IDEALS) was used to measure in non-enhancing MS lesions of 11 relapse-remitting MS patients. Although the permeability for MRI contrast in non-enhancing MS lesions is several orders of magnitude lower than that of enhancing MS lesions, our study demonstrated a robust reduction of lesion water permeability.}
}
@inproceedings{ISMRM2018_4922,
annote={ISMRM2018_4922},
pages={4922},
file={ISMRM2018_4922.pdf:ISMRM2018_4922.pdf:PDF},
title={Epidermal Growth Factor's lowers Blood Brain Barrier leakiness in an Alzheimer's disease mouse model as detected using Diffusion Weighted Arterial Spin Labeling {MR} Imaging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4922.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Frederick C Damen and Riya Thomas and Rong-Wen Tain and Weiguo Li and Leon Tai and Kejia Cai},
abstract={Blood-brain barrier (BBB) dysfunction is reemerging as a critical component of Alzheimer’s disease (AD). Higher BBB leakiness is one of the mechanistic pathways through which AD risk factors induce cognitive decline. We have previously demonstrated that epidermal growth factor (EGF) prevents BBB leakiness in a model of two important AD risk factors: APOE4 and female sex (female E4FAD mice). The goal of this study was to use Diffusion Weighted Arterial Spin Labeling MRI to determine whether post-symptomatic EGF treatment, (during 8-10 months) can reduce BBB leakiness in EGF treated mice compared to vehicle controls.}
}
@inproceedings{ISMRM2018_4923,
annote={ISMRM2018_4923},
pages={4923},
file={ISMRM2018_4923.pdf:ISMRM2018_4923.pdf:PDF},
title={Imaging Blood Brain Barrier Disruption in Multiple Sclerosis using Gluco{CEST} {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4923.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Xiang Xu and Pavan Bhargava and Linda Knutsson and Martin Pomper and Peter Calabresi and Peter C.M. van Zijl},
abstract={It has been demonstrated that glucose can be used as a contrast agent for chemical exchange saturation transfer (glucoCEST) and enhanced relaxation (T2 or T1ρ). In the present work we show the possibility of detecting blood brain barrier (BBB) disruption in multiple sclerosis (MS) using glucoCEST MRI at 7T and 3T. At both field strengths, glucoCEST enhancement was observed in some MS lesions that were not enhanced by Gd T1w images. Our results show that glucose may be more permeable than Gd to minor BBB disruptions, suggesting that glucose transport may also be more sensitive to MS disease activities.}
}
@inproceedings{ISMRM2018_4924,
annote={ISMRM2018_4924},
pages={4924},
file={ISMRM2018_4924.pdf:ISMRM2018_4924.pdf:PDF},
title={High Resolution {UTE}-{MRA}s for Longitudinal Visualization of Revascularization and Blood-Brain Barrier Disruption on a Rat Transient Middle Cerebral Artery Occlusion Model},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4924.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={MungSoo Kang and HyungJoon Cho},
abstract={Longitudinal study of revascularization and BBB disruption after ischemic stroke provides prognostic and therapeutic information. In this work, high resolution UTE-MRAs with superparamagnetic iron oxide nanoparticles (SPION) were performed on a rat tMCAO model to visualize revascularization and BBB disruption longitudinally. UTE-MRAs before and after SPION injection clearly visualized arterial vessels and all vessels, respectively. Thickened and twisted vessels at the rat brain surface of ipsilateral hemisphere were highly resolved (59 μm
3 isotropic).}
}
@inproceedings{ISMRM2018_4925,
annote={ISMRM2018_4925},
pages={4925},
file={ISMRM2018_4925.pdf:ISMRM2018_4925.pdf:PDF},
title={Glycine is an early 'biomarker' of blood brain barrier breakdown in Gliomas},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4925.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Vivek Tiwari and Zhongxu An and Yiming Wang and Michael Levy and Marco Pinho and Elizabeth A. Maher and Edward Pan and Toral Patel and Bruce E. Mickey and Changho Choi},
abstract={Cancer cells may use altered metabolic pathways with respect to their normal counterparts; this metabolic switch is necessary to support their rapid proliferation in oxygen- and nutrient-poor conditions. A few of the metabolites are up-regulated while some others are down-regulated or unaltered. High grade malignant tumors present with enhancement on T1-weighted (T1w) image. Enhancement on post-contrast T1w images is an indicative of breakdown of blood brain barrier (BBB). The increased number of tumor cells may stress the vessels and, thus BBB tend to rupture. A non-invasive bio-marker that can predict the disruption of BBB will be of great clinical significance for assessing the tumor aggressiveness. Here, we show elevated Gly can be a potential bio-marker for predicting the tumor’s potential to present with ruptured BBB.}
}
@inproceedings{ISMRM2018_4926,
annote={ISMRM2018_4926},
pages={4926},
file={ISMRM2018_4926.pdf:ISMRM2018_4926.pdf:PDF},
title={Increased vascular permeability in the lenticulostriate arteries results in increased hemosiderin deposition in the basal ganglia in aging and cognitive impairment},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4926.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Axel Montagne and Giuseppe Barisano and Meng Law and Farshid Sepherband and Arthur Toga and Berislav Zlokovic},
abstract={The intramural periarterial drainage pathway is critical for the elimination of metabolic waste products from the brain. In a number of neurological diseases such as Alzheimer’s Disease, blood-brain barrier damage and increased vascular permeability may play an important role in the pathogenesis. Leakiness of the blood-brain barrier allows fibrin(ogen), hemosiderin and metabolic wastes to exudate and deposit around the vessels in the basal ganglia. In order to test this hypothesis, we evaluated the relationship between blood-brain barrier permeability measured as ktrans and hemosiderin deposition in 76 subjects scanned at 3T MRI.}
}
@inproceedings{ISMRM2018_4927,
annote={ISMRM2018_4927},
pages={4927},
file={ISMRM2018_4927.pdf:ISMRM2018_4927.pdf:PDF},
title={Exercise selectively increases cerebral blood flow in the postcentral gyrus in patients with Huntington’s disease},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4927.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jessica Steventon and Hannah Furby and Richard Wise and Kevin Murphy},
abstract={The therapeutic potential of exercise - a potent trigger for both neurogenesis and vascular plasticity - is currently a hot research topic in neurodegenerative diseases. Here we tested whether a single 20-minute bout of aerobic exercise was sufficient to induce changes in cerebral blood flow (CBF) in people with Huntington’s disease (HD). We find a transient and selective increase in CBF in the postcentral gyrus in HD participants following exercise, a region with reduced intrinsic functional connectivity in HD patients, with no change in healthy controls. The CBF change was unrelated to clinical and genetic markers of disease.}
}
@inproceedings{ISMRM2018_4928,
annote={ISMRM2018_4928},
pages={4928},
file={ISMRM2018_4928.pdf:ISMRM2018_4928.pdf:PDF},
title={Impact of focused ultrasound on cerebral blood flow},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4928.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Vasile Stupar and Anthony Delalande and Nora Collomb and Claire Rome and Emmanuel L. Barbier},
abstract={One major application of FUS is the opening of the blood brain barrier (BBB) to target the brain cells with drugs such as in glioma. While the impact of FUS on brain disease is under intense evaluation, its impact of normal brain physiology has received less attention. In this study, we evaluate the impact of BBB opening using FUS on cerebral blood flow (CBF), assessed by pseudo-continuous arterial spin labeling (ASL). Following 0.6MPa FUS at 1.2Mhz, a small change in ADC was observed, suggesting a small vasogenic edema. In addition, there was a 50\%CBF reduction in a large vascular territory.}
}
@inproceedings{ISMRM2018_4929,
annote={ISMRM2018_4929},
pages={4929},
file={ISMRM2018_4929.pdf:ISMRM2018_4929.pdf:PDF},
title={Age-related shift of cerebral venous outflow pathway detected by {BOLD} signal-based blood flow tracking},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4929.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Toshihiko Aso and Shinnichi Urayama and Tsukasa Ueno and Naoya Oishi and Yukako Nakagami and Toshiya Murai and Hidenao Fukuyama},
abstract={A novel blood tracking technique based on BOLD MRI signal was applied to two age groups of healthy subjects (n=81) to investigate age-related alterations in cerebral circulation. By mapping the phase of low-frequency component and between-subject regression analysis on this “BOLD lag map”, linear extension of venous drainage times with age was found in the deep venous system draining the periventricular region. Interestingly, age-related shortening of washout time was observed in the superficial system involving the major sinuses. This dissociation of deep and superficial venous systems may reflect focal inefficiency in the deep system as part of normal aging processes.}
}
@inproceedings{ISMRM2018_4930,
annote={ISMRM2018_4930},
pages={4930},
file={ISMRM2018_4930.pdf:ISMRM2018_4930.pdf:PDF},
title={Cerebral Blood Flow, Intracranial Volumes and Cognitive Status in Type-2 Diabetes Mellitus},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4930.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Leanne Hunt and Dinesh Selvarajah and Solomon Tesfaye and Iain D Wilkinson},
abstract={This study quantitates regional brain volumes and arterial cerebral perfusion characteristics (ASL) in patients with Type-2 Diabetes Mellitus (T2DM) who have Mild Cognitive Impairment, in patients with T2DM who have normal cognitive status and in non-diabetic healthy volunteers. Mean group differences were identified in both grey matter volume and cerebral blood flow in regions that include the medial temporal lobes. These findings may further our understanding of the mechanisms that lead to an increased risk of the development of cognitive impairment associated with diabetes.}
}
@inproceedings{ISMRM2018_4931,
annote={ISMRM2018_4931},
pages={4931},
file={ISMRM2018_4931.pdf:ISMRM2018_4931.pdf:PDF},
title={Aortic flow and cerebral hemodynamics in age-related brain volume loss},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4931.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ann Ragin and Can Wu and Guixiang Ma and Sameer A. Ansari and Michael Markl and Susanne Schnell},
abstract={Concurrent cardiac and neurovascular (4D flow) MR imaging were used to quantify cardiac and cerebral hemodynamics in 30 healthy adults to determine the relationship to brain volumetric measures of regions considered vulnerable in aging. Cardiac index (p=0.001); ascending aorta (p=0.003) total cerebral blood flow (p=0.001) and flow for left internal carotid (p<0.001), basilar (p=0.04) and right anterior cerebral (p=0.03) arteries were significantly lower in midlife compared to younger adults. Lower cardiac index, total cerebral blood flow and left internal carotid flow were correlated with reduced gray matter, superior frontal cortical thinning and volume loss in putamen.}
}
@inproceedings{ISMRM2018_4932,
annote={ISMRM2018_4932},
pages={4932},
file={ISMRM2018_4932.pdf:ISMRM2018_4932.pdf:PDF},
title={Altered cerebral blood flow before and after 4-weeks of neurostimulation in patients with episodic migraine},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4932.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Lars Michels and Jessica Aschmann and Franz Riederer and Andreas Gantenbein and Roger Luechinger and Spyros Kolllias and Peter Sandor},
abstract={Cerebral blood flow is altered in migraineurs but it is unknown if this can be changed by repetitive neurostimulation, leading to less migraine attacks. In a double blind and sham-controlled study, we used arterial spin labeling MRI and transcranial direct current stimulation (tDCS) to address this question. Four weeks of real tDCS diminished initial hyperperfusion in patients with episodic migraine in pain processing brain regions (p < 0.001). In addition, less migraine attacks occurred after real tDCS compared to baseline (p < 0.05). Our results indicate a regulating effect of tDCS on cerebral blood flow and clinical outcome in migraineurs.}
}
@inproceedings{ISMRM2018_4933,
annote={ISMRM2018_4933},
pages={4933},
file={ISMRM2018_4933.pdf:ISMRM2018_4933.pdf:PDF},
title={Quantifying brain oxygen extraction fraction: correlation between a global venous susceptibility method and calibrated f{MRI} mapping method.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4933.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Hannah L Chandler and Michael Germuska and Thomas W Okell and Ana E Rodriguez-Soto and Erin K Englund and Rachael C Stickland and Catherine Foster and Jessica Steventon and Fabrizio Fasano and Kevin Murphy and Valentina Tomassini and Felix W Wehrli and Richard G Wise},
abstract={Measuring oxygen extraction fraction (OEF) may prove a useful clinical tool for assessing brain oxygen consumption. Dual-calibrated fMRI is used to map voxel-wise OEF across grey-matter and requires respiratory challenge (hypercapnia and hyperoxia). However, this method presents challenges to clinical implementation. Conversely, OxFlow provides a global estimate of OEF, has a shorter acquisition time and does not require respiratory challenge. Here we examine the relationship between both approaches for measuring OEF, revealing a significant association between methods. While further investigation is required, OxFlow may offer additional clinical utility for measuring cerebral oxygen consumption.}
}
@inproceedings{ISMRM2018_4934,
annote={ISMRM2018_4934},
pages={4934},
file={ISMRM2018_4934.pdf:ISMRM2018_4934.pdf:PDF},
title={{MR} susceptometry based superior sagittal sinus venous oxygen saturation: effects of carbon dioxide based cerebral vascular reserve and anesthesia in Moyamoya patients},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4934.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Chou-Ming Cheng and Tzu-Chen Yeh and Jen-Chuen Hsieh and Hsiao-Wen Chung},
abstract={Venous oxygen saturation (SvO
2) is measured on Moyamoya patients with previous proposed automatic methods based on MR susceptometry from the phase information obtained with multi-echo gradient-echo imaging. According to anesthesia condition and carbon dioxide based cerebral vascular reserve (CO
2-CVR) using blood oxygen level dependence (BOLD) technique, 21 Moyamoya patients are classified into four groups. Results from them suggested that global SvO
2 value may indicate global pathophysiological change supported by reduced SvO
2 without obviously impaired CO
2-CVR and elevated SvO
2 under anesthesia.}
}
@inproceedings{ISMRM2018_4935,
annote={ISMRM2018_4935},
pages={4935},
file={ISMRM2018_4935.pdf:ISMRM2018_4935.pdf:PDF},
title={Assessment of Intravenous Immunoglobulin treatment on {BBB} function following inflammation},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4935.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Oliviero L. Gobbo and Aislinn Mc Phillips and Tara Hamilton and Jerrard Hayes and Gavin Davey},
abstract={The blood brain barrier (BBB) is a complex structure that separates brain interstitial fluid from blood. BBB dysfunction is a key feature of Central Nervous System diseases. This in vivo study examines the effects of Intravenous Immunoglobulin (IVIg), regularly used to treat immune and inflammatory diseases, on BBB function following LPS-induced BBB disruption. The change in permeability of the BBB was evaluated by MRI, using gadolinium. Our results suggest that LPS breach the integrity of the BBB with regional specificity and can be reversed by IVIg administration.}
}
@inproceedings{ISMRM2018_4936,
annote={ISMRM2018_4936},
pages={4936},
file={ISMRM2018_4936.pdf:ISMRM2018_4936.pdf:PDF},
title={Permeability of the blood-brain barrier predicts no evidence of disease activity at two years after natalizumab or fingolimod treatment in relapsing-remitting multiple sclerosis},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4936.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Stig P Cramer and Helle J Simonsen and Ulrich Lindberg and Aravinthan Varatharaj and Ian Galea and Jette Frederiksen and Henrik BW Larsson},
abstract={Dynamic contrast-enhanced MRI enables measurements of the permeability of the blood-brain barrier (BBB), possibly a marker of disease activity in multiple sclerosis (MS). In order to investigate if permeability predicts early suboptimal treatment response, defined as loss of no evidence of disease activity (NEDA) status after two years, we included 35 relapsing-remitting MS patients initiating either fingolimod or natalizumab, drugs with a common effect of decreasing lymphocyte influx into the CNS. We find that permeability measured after six months of treatment was a good predictor loss of NEDA status at two years and a surrogate marker of the state of health of the blood-brain barrier.}
}
@inproceedings{ISMRM2018_4937,
annote={ISMRM2018_4937},
pages={4937},
file={ISMRM2018_4937.pdf:ISMRM2018_4937.pdf:PDF},
title={Imaging correlates of the Blood Brain Barrier disruption in {HIV} associated neuro cognitive disorder and therapeutic implications},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4937.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Joga Chaganti and Bruce James Brew},
abstract={. Neurocognitive impairment in HIV infection, known as HIV associated neurocognitive disorder (HAND), in the context of suppressive combination antiretroviral therapy still occurs. We hypothesized that ongoing chronic systemic inflammation, a feature of HIV disease despite viral suppression, causes blood brain barrier (BBB) disruption thereby allowing entry of neurotoxic cytokines/chemokines or HIV itself (in very low levels because of suppression) thereby causing HAND or at least worsening it. To test this hypothesis, we have used dynamic contrast enhancement derived metrics (K-trans) to measure the capillary permeability as, a direct indicator for possible BBB disruption and correlated it with neuro inflammatory markers in the cerebrospinal fluid (CSF ) MR spectroscopy derived metabolites as well as with clinical indices of neurocognition (neuropsychological scores).
}
}
@inproceedings{ISMRM2018_4938,
annote={ISMRM2018_4938},
pages={4938},
file={ISMRM2018_4938.pdf:ISMRM2018_4938.pdf:PDF},
title={Effects of Track Length on White Matter Alterations in Mild Traumatic Brain Injury},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4938.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Sourajit Mitra Mustafi and Jaroslaw Harezlak and Joaquin Goni and Laura A Flashman and Thomas W McAllister and Yu-Chien Wu},
abstract={In the present study, we performed streamline tractography to characterize effects of track length on white-matter microstructural alterations after mild traumatic brain injury. Streamline length and counts were studied in involved white-matter fiber tracts that were found to have decreased axonal density at some points along the tracts using voxel-based analyses. The results suggested that long fibers in the brains of individuals who sustained mild traumatic brain injury are more vulnerable to the injury.}
}
@inproceedings{ISMRM2018_4939,
annote={ISMRM2018_4939},
pages={4939},
file={ISMRM2018_4939.pdf:ISMRM2018_4939.pdf:PDF},
title={Regional fractional anisotropy and processing speed in diffuse traumatic brain injury: An exploratory analysis using a linear regression panel model},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4939.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Sindhuja T Govindarajan and David J Ouellette and Junghoon Kim and Tim Q Duong},
abstract={Recently, Ware and colleagues
1 showed that FA-derived damage assessment in WM regions can accurately classify subjects with processing speed impairment in moderate to severe diffuse TBI at 3 months post-injury. Using a subset of the same cohort who completed follow-up DTI scans at 6 and 12 months post-injury, the goals of this study were 1) to investigate if regional FA remains associated with processing speed in a dataset including all time points and 2) to conduct an exploratory analysis to identify a subset of regions that can best explain such association. Four regions were identified that explained most variance in processing speed.}
}
@inproceedings{ISMRM2018_4940,
annote={ISMRM2018_4940},
pages={4940},
file={ISMRM2018_4940.pdf:ISMRM2018_4940.pdf:PDF},
title={Within-Subject Characterization of Sports Concussion with Serial Diffusion {MRI} and Spherical Mean Technique},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4940.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Matthew Budde and L. Tugan Muftuler and Andrew Nencka and Kevin Koch and Yang Wang and Timothy Meier and Michael McCrea},
abstract={Diffusion tensor imaging is a promising biomarker of mild Traumatic Brain Injury and concussion, but it has not been refined sufficiently for diagnosis in individual subjects. In this study, we demonstrate that spherical mean technique (SMT) diffusion MRI can detect post-concussion changes in single subjects over the acute recovery period.}
}
@inproceedings{ISMRM2018_4941,
annote={ISMRM2018_4941},
pages={4941},
file={ISMRM2018_4941.pdf:ISMRM2018_4941.pdf:PDF},
title={Characterizing acute, subacute and chronic changes in the brain following sport-related concussion using Diffusion Kurtosis Tensor Imaging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4941.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={L. Tugan Muftuler and Timothy B. Meier and Daniel V. Olson and Michael A. McCrea},
abstract={The aim of this study was to characterize acute, subacute and chronic changes in the brain following sport-related concussion in a group of young athletes. Diffusion kurtosis tensor parameters were compared between concussed athletes and controls. The concussed group demonstrated widespread increase in axial kurtosis compared to the controls at the acute time point, which gradually diminished over the course of 14 days. Conversely, alterations in radial kurtosis were mostly in the frontal white and gray matter and occipital gray matter regions. These findings may have important implications for the clinical management of sport-related concussions.}
}
@inproceedings{ISMRM2018_4942,
annote={ISMRM2018_4942},
pages={4942},
file={ISMRM2018_4942.pdf:ISMRM2018_4942.pdf:PDF},
title={Evaluating Microstructural Integrity of Cortical and Deep Gray Matter over a Season of High School Football Using Diffusion Kurtosis Imaging and Quantitative Susceptibility Mapping},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4942.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Nan-Jie Gong and Samuel Kuzminski and Michael Clark and Melissa Fraser and Mark Sundman and Kevin Guskiewicz and Jeffrey R Petrella and Chunlei Liu},
abstract={Over the course of a single high school football season, QSM showed no evidence of microhemorrhage or iron-related changes; however, we observed significant microstructural alterations, as reflected by DKI metrics, in cortical and deep gray matter over the course of a single high school football season. These microstructural changes correlated with the frequency of head impacts, suggesting that DKI imaging of cortical and deep gray matter may yield valuable biomarkers for tracking subclinical traumatic brain injury in contact-sport athletes.}
}
@inproceedings{ISMRM2018_4943,
annote={ISMRM2018_4943},
pages={4943},
file={ISMRM2018_4943.pdf:ISMRM2018_4943.pdf:PDF},
title={Exploring the effects of concussion history on quantitative estimation of temporal delays and cerebrovascular reactivity: A novel approach combining hypercapnia and hyperoxia in collegiate football players},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4943.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={ALLEN A. CHAMPAGNE and NICOLE S. COVERDALE and ALEX A. BHOGAL and DOUGLAS J. COOK},
abstract={Recent evidence suggests that concussion history may be associated with long-term structural and functional changes in the brain. However, little is known about the effects of head injury on vascular reactivity. In this study, we combined hypercapnic and hyperoxic respiratory manipulations to explore the effects of concussion history on hemodynamic latencies and tissue cerebrovascular reactivity (CVR) in football players. We found that, although tissue CVR was not different between the groups (P>0.05), time delays to hypercapnia were shorter in subjects with a history of concussion (P<0.05), which may suggest some compensatory mechanism in the vasculature that persists beyond clinical recovery.}
}
@inproceedings{ISMRM2018_4944,
annote={ISMRM2018_4944},
pages={4944},
file={ISMRM2018_4944.pdf:ISMRM2018_4944.pdf:PDF},
title={Investigating tissue oxygenation in acute Traumatic Brain Injury using Arterial Spin Labelling and quantitative-{BOLD}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4944.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Alan J Stone and Tim P Lawrence and Thomas W Okell and Natalie L Voets and Nicholas P Blockley},
abstract={Following a traumatic brain injury, oxygen metabolism may be disrupted by changes in oxygen supply and demand. This study aims to investigate global changes in oxygen metabolism in the hours immediately following the initial insult to the brain. Pseudo-continuous ASL (PCASL) and streamlined-qBOLD (sqBOLD) are used to measure blood flow and oxygenation in the acute stages of TBI (<24 hours post-injury). When compared with an age matched control group, blood oxygenation appears to increase during injury (decreased OEF (p=0.03)) at this acute time-point.}
}
@inproceedings{ISMRM2018_4945,
annote={ISMRM2018_4945},
pages={4945},
file={ISMRM2018_4945.pdf:ISMRM2018_4945.pdf:PDF},
title={{DTI} Connectome Analysis in Moderate {TBI}: Parcellation Improves Detection of Relevant Injury and the Monitoring of Therapeutic Response},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4945.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={TALAIGNAIR N VENKATRAMAN and RYAN PEARMAN and HAICHEN WANG and CHRIS PETTY and ALLEN W SONG and DANIEL T LASKOWITZ and CHRISTOPHER D LASCOLA},
abstract={Conventional DTI readouts such as fractional anisotropy (FA), axial diffusion (RD) and radial diffusion (RD) show distinct alterations following closed head injury but do not correlate well with measured functional and cognitive outcomes. 3D DTI with parcellated connectome analysis reveals neural fiber networks between brain regions that are most vulnerable to closed head (acceleration-deceleration) injury and also most relevant to measurable functional deficits. In this study, fiber tract number between hippocampus and cortex is the most sensitive marker of both motor and memory deficits and therapeutic improvement following administration of a novel neuroprotective therapeutic agent.}
}
@inproceedings{ISMRM2018_4946,
annote={ISMRM2018_4946},
pages={4946},
file={ISMRM2018_4946.pdf:ISMRM2018_4946.pdf:PDF},
title={Working Memory And White Matter Microstructure In Mild Traumatic Brain Injury},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4946.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Sohae Chung and Els Fieremans and Xiuyuan Wang and Charles J Morton and Dmitry S Novikov and Joseph F Rath and Yvonne W Lui},
abstract={Working memory is a critical cognitive function implicated after mild traumatic brain injury (MTBI). Here, we investigate the association between white matter microstructure and working memory in normal controls (NC) and MTBI patients, using diffusion white matter tract integrity (WMTI) and WAIS-IV subtests, respectively. For the NC group, significant correlations were observed in axonal water fraction (AWF; higher axonal density/myelination) and mean kurtosis (MK; greater tissue complexity) with letter-number sequencing (LNS). However, such relationships were not present in the MTBI group.}
}
@inproceedings{ISMRM2018_4947,
annote={ISMRM2018_4947},
pages={4947},
file={ISMRM2018_4947.pdf:ISMRM2018_4947.pdf:PDF},
title={{CNR} comparison to identify the detectability rate and {FA} histogram analysis of {FLAIR} lesions in {DTI} metrics.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4947.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ramtilak Gattu and Randall R Benson and Ewart M Haacke},
abstract={There is a paucity of studies trying to investigate the sensitivity of DTI metrics like Fractional Anisotropy (FA), Apparent Diffusion Coefficient (ADC), Axial Diusivity and Radial Diffusivity in areas corresponding to the lesion sites detected in clinical MRI using FLAIR images. Aim of this study was to compare the utility of DTI with FLAIR by evaluating the contrast to noise ratio (CNR) in their detecting capacity of DAI lesions and to evaluate whether DTI is more accurate than FLAIR or vice versa.}
}
@inproceedings{ISMRM2018_4948,
annote={ISMRM2018_4948},
pages={4948},
file={ISMRM2018_4948.pdf:ISMRM2018_4948.pdf:PDF},
title={Using f{MRI} to assess cerebrovascular reactivity after acute concussion},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4948.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Nathan W Churchill and Michael Hutchison and Simon Graham and Tom Schweizer},
abstract={Cerebrovascular reactivity (CVR) is an important biomarker of concussion, as brain activity and blood flow regulation are often impaired after brain injury. This study examines an fMRI breath hold paradigm as a probe of CVR in concussed athletes, showing significant variations with days post-injury.}
}
@inproceedings{ISMRM2018_4949,
annote={ISMRM2018_4949},
pages={4949},
file={ISMRM2018_4949.pdf:ISMRM2018_4949.pdf:PDF},
title={Functional correlates of microstructural damage in developmental traumatic brain injury: a multi-modal {MRI} study of neuroanatomy, cerebrovascular reactivity and functional connectivity},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4949.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Maxime Parent and Ying Li and Basavaraju G. Sanganahalli and Vijayalakshmi Santhakumar and D.S. Fahmeed Hyder and Sridhar Kannurpatti},
abstract={The developing brain is particularly vulnerable to traumatic brain injury (TBI), with symptoms and co-morbidities lasting into adulthood. Animal models of developmental TBI are useful tools for investigating molecular pathways of TBI injuries and to assess novel therapeutics; however, validation of in vivo injury biomarkers in these models is important for the translational application of pre-clinical findings. Here, we demonstrate that the persistent dysfunctions of developmental TBI in an animal model can be measured at the level of microstructural damage (with diffusion MRI), functional interhemispheric connectivity (with resting-state fMRI) and systemic neurovascular coupling (with CO2 challenge fMRI).}
}
@inproceedings{ISMRM2018_4950,
annote={ISMRM2018_4950},
pages={4950},
file={ISMRM2018_4950.pdf:ISMRM2018_4950.pdf:PDF},
title={Military {TBI} Patients Demonstrate Increased Cerebral Venous Volume Using Quantitative Susceptibility Mapping},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4950.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Wei Liu and Gerard Riedy and Ping-Hong Yeh and Dominic E Nathan and Chihwa Song and Grant H Bonavia and John Ollinger},
abstract={Cerebral venous volume above the lateral ventricle was analyzed using quantitative susceptibility mapping in patients with severe (n = 7), moderate (n = 21) and mild (n = 27 for blast and n = 19 for nonblast) TBI. Severe and moderate TBI patients both demonstrated increased venous volume compared to control subjects without history of TBI. Blast injured mild TBI patients also showed increased venous volume compared to the control subjects. These results suggest that microvascular injury may present in TBI patients and blast related injury might have a more pronounced impact on the venous system.}
}
@inproceedings{ISMRM2018_4951,
annote={ISMRM2018_4951},
pages={4951},
file={ISMRM2018_4951.pdf:ISMRM2018_4951.pdf:PDF},
title={Transient neuronal dysfunction correlates with hypo-perfusion in patients with moderate post-traumatic brain injury},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4951.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Eva-Maria Ratai and Suk-tak Chan and Maria Gabriela Figueiro Longo and Michael Wenke and Termara Parker and Jonathan Welt and Joyce van Loon and Emad Ahmadi and Anastasia Yendiki and Jacqueline Namati and Isabel Chico-Calero and Blair Parry and Can Ozan Tan and Jarone Lee and Michael Lev and Michael Hamblin and Benjamin Vakoc and Rajiv Gupta},
abstract={We present a DOD funded study to assess the effects of low-level light therapy (LLLT) on metabolites measured by MRS and cerebral perfusion measured by ASL using a double-blind, placebo controlled study where patients with moderate TBI were randomized between LLLT and sham treatment. We report CBF and metabolic changes pertaining to neuronal injury and neuroinflammation for the entire cohort (i.e., both treated and control arms), before the blind is broken. Our findings suggest that transient neuronal dysfunction in the posterior cingulate cortex and neuroinflammation in the thalamus correlated with hypo-perfusion during the subacute phase of moderate TBI.}
}
@inproceedings{ISMRM2018_4952,
annote={ISMRM2018_4952},
pages={4952},
file={ISMRM2018_4952.pdf:ISMRM2018_4952.pdf:PDF},
title={Eye motion artifacts in T2-weighted images, identified by deep neural networks, correlate with concussion},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4952.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Andrew S. Nencka and John D. Bukowy and Robin A. Karr and Andrew P. Klein and Kevin M. Koch and Peter LaViolette and Sean D. McGarry and Timothy B. Meier and Brad J. Swearingen and Michael McCrea},
abstract={Oculomotor deficits occur with traumatic brain injury and eye motion yields artifacts in the phase encoding directions of common MRI acquisitions. Here we quantify motion artifacts in regions of interest of T2-weighted MRI head images in concussed and healthy high school and collegiate athletes. Regions of interest over eyes and inner ear structures as a control, were automatically generated using a convolutional neural network. Acute and sub-acute injury was found to yield significantly increased motion artifact compared to controls in ROIs covering eyes. No differences in motion artifacts covering inner ear structures were found. These results indicate that anatomical MRI following traumatic brain injury may offer increased diagnostic or prognostic information through artifact resulting from eye motion associated with injury.}
}
@inproceedings{ISMRM2018_4953,
annote={ISMRM2018_4953},
pages={4953},
file={ISMRM2018_4953.pdf:ISMRM2018_4953.pdf:PDF},
title={Alteration of Resting-state Functional Networks is Associated with Post Concussion Symptoms in Mild Traumatic Brain Injury},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4953.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Nai-Chi Chen and Chia-Feng Lu and Li-Chun Hsieh and Sho-Jen Cheng and Yu-Chieh Jill Kao and Ho-Fang Huang and Cheng-Yu Chen},
abstract={A subgroup of patients with mild traumatic brain injury (mTBI) suffer from a series of post-concussion symptoms, such as headache, dizziness and cognitive deficits. These patients also present altered neural connectivity compared to healthy controls (HC). In our study, we examined resting-state functional connectivity in 30 mTBI patients and 35 HC using independent component analysis. We found that patients showed lower functional connectivity in several resting-state networks and the left frontoparietal network was associated with the level of dizziness in patients. We concluded that the alterations of resting-state neural networks may support post-concussion symptoms after mTBI.}
}
@inproceedings{ISMRM2018_4954,
annote={ISMRM2018_4954},
pages={4954},
file={ISMRM2018_4954.pdf:ISMRM2018_4954.pdf:PDF},
title={Low-frequency Fluctuations of Resting-state f{MRI} {BOLD} Signal after Experimental Mild Traumatic Brain Injury},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4954.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yu-Chieh Jill Kao and Chia-Feng Lu and Ping-Huei Tsai and Fei-Ting Hsu and Bao-Yu Hsieh and Cheng-Yu Chen},
abstract={Regionalamplitude of rsfMRI BOLD signal after mTBI was quantified using amplitudeof low-frequency fluctuation (ALFF). The significant increase of ALFF around the impact regions at 24 h and renormalized at 50 days after mTBImay suggest the dynamics of neuronal activity and neurovascular response induced by the injury.}
}
@inproceedings{ISMRM2018_4955,
annote={ISMRM2018_4955},
pages={4955},
file={ISMRM2018_4955.pdf:ISMRM2018_4955.pdf:PDF},
title={Altered Functional Connectivity and Network Topology in Active Profession Fighters},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4955.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Karthik R Sreenivasan and Zhengshi Yang and Virendra Mishra and Sarah Banks and Dietmar Cordes and Charles Bernick},
abstract={Studies have shown that both active and retired athletes with repeated head trauma are more likely to suffer from cognitive decline and loss of executive and attention functions when compared to age- matched healthy controls. Our results show decreased functional connectivity in the active fighter group when compared to controls between regions known to be implicated in traumatic brain injury. Furthermore, we found a shift towards a less efficient network topology with altered integration and segregation in active professional fighters.}
}
@inproceedings{ISMRM2018_4956,
annote={ISMRM2018_4956},
pages={4956},
file={ISMRM2018_4956.pdf:ISMRM2018_4956.pdf:PDF},
title={Gluco{CEST} weighted {MRI} detects metabolic abnormalities following experimental {TBI} on 7T and 9.4T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4956.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Tsang-Wei Tu and Jaclyn Witko and Joseph Frank},
abstract={Delayed glucose hypometabolism has been reported in traumatic brain injury (TBI) patients from weeks to years posing a high risk for neurodegenerative diseases. This study shows the feasibility of glucoCEST weighted MRI (GWI) to detect metabolic abnormalities following TBI on 7T and 9.4T. The GWI results were compared to 2DG autoradiography and immunohistochemitry indicating that the injured brain needed immediate energy to restore nervous function and then entered a hypometabolism state in week 2. GWI affords the sensitivity to detect cerebral metabolic states following TBI and has potential to identify the treatment window to increase neuronal survival.}
}
@inproceedings{ISMRM2018_4957,
annote={ISMRM2018_4957},
pages={4957},
file={ISMRM2018_4957.pdf:ISMRM2018_4957.pdf:PDF},
title={Transient disappearance of traumatic microbleeds on susceptibility weighted imaging in rats},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4957.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Arnold Tóth and Bálint Soma Környei and Zoltán Berente and Endre Czeiter and Krisztina Amrein and Péter Bogner and Tamás Dóczi and András Büki and Attila Schwarcz},
abstract={Traumatic microbleeds (TMBs) are regarded as markers of traumatic brain injury (TBI) related diffuse axonal injury (DAI). According to several recently published observations, TMBs depicted by susceptibility weighted imaging (SWI), seems to show temporal changes. This study aims to explore the temporal features of TMBs in a rat model.}
}
@inproceedings{ISMRM2018_4958,
annote={ISMRM2018_4958},
pages={4958},
file={ISMRM2018_4958.pdf:ISMRM2018_4958.pdf:PDF},
title={Gray matter volume changes following Cranial Nerve Non-invasive NeuroModulation in patients with traumatic brain injuries},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4958.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jiancheng Hou and Arman Kulkarni and Neelima Tellapragada and Veena Nair and Mitch Tyler and Yuri Danilov and Kurt Kaczmarek and Beth Meyerand and Vivek Prabhakaran},
abstract={The main conventional approach for treating traumatic brain injury related gait and balance deficits has been through physical therapy, but few approaches have focused on brain based rehabilitation efforts that create direct neuroplastic changes. There remains a need for such an approach. Therefore, the goal of this study was: 1) to apply Cranial Nerve Non-Invasive NeuroModulation (CN-NINM) via the tongue in combination with multiple symptom-specific physical therapy exercises in patients with mild to moderate TBI and 2) to investigate and quantify gray matter volume changes prior to and after intervention as well as their correlation with behavior.}
}
@inproceedings{ISMRM2018_4959,
annote={ISMRM2018_4959},
pages={4959},
file={ISMRM2018_4959.pdf:ISMRM2018_4959.pdf:PDF},
title={Novel Processing of Magnetic Resonance Spectroscopy Enables Biomarker Discovery for {PTSD} and m{TB}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4959.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={John M. Irvine and Laura Mariano and Ben Rowland and Huijun Liao and Kristin Heaton and Alexander P Lin},
abstract={The objective of this study was to determine the neurochemical biomarkers for mild traumatic brain injury (mTBI) and posttraumatic stress disorder (PTSD) among members of the military. A sample of 100 participants were assigned to each cohort (mTBI only, PTSD only, mTBI and PTSD, military control and civilian control). Analysis of metabolite concentrations in the mTBI and PTSD cohorts showed significant metabolite difference across 3 voxels in the brain (posterior cingulate gyrus (PCG), anterior cingulate cortex (ACC) and posterior white matter (PWM)), indicating that magnetic resonance spectroscopy provides objective biomarkers for distinguishing these conditions.}
}
@inproceedings{ISMRM2018_4960,
annote={ISMRM2018_4960},
pages={4960},
file={ISMRM2018_4960.pdf:ISMRM2018_4960.pdf:PDF},
title={Assessment of metabolic changes in traumatic brain injury using hyperpolarized [1-13C]pyruvate: a longitudinal study},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4960.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Edward Hackett and Laura Ingle and Brenda Bartnik-Olson and Jae Mo Park},
abstract={In this study, we longitudinally assessed acute metabolic changes during 2-120hrs post traumatic brain injury in a controlled-cortical impact rat model using hyperpolarized [1-
13C]pyruvate. We observed mildly increased pyruvate conversion to lactate and significantly reduced bicarbonate production in the injured site at 24hrs after impact. Conversely, lactate was reduced when measured at 48hrs-post injury. Bicarbonate production in the lesion remained low with significantly increased bicarbonate production in the contralateral normal-appearing brain}
}
@inproceedings{ISMRM2018_4961,
annote={ISMRM2018_4961},
pages={4961},
file={ISMRM2018_4961.pdf:ISMRM2018_4961.pdf:PDF},
title={Hippocampal-Cerebellar metabolic investigation in {TBI} rats: {NMR} spectroscopy study},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4961.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Subash Khushu and Kavita Singh and Richa Trivedi and Sonia Gandhi and Poonam Rana},
abstract={Cerebellar atrophy and dysfunction has been reported in clinical TBI. hippocampal-cerebellar cognitive collaborations and its manifestation in TBI is being reported. This study investigated TBI mediated metabolic irregularities in CB and HP in animal model of TBI. These results indicated that CB and HP are metabolically different regions. The models generated from the changes due to trauma could accurately discriminate CB and HP and injury severity. We speculate that reduced NAA and Cho levels may be due to substantial focal neuronal loss after weight drop TBI. Edema and excitotoxity following injury leads to altered levels of osmolytes and Glu/Gln.
}
}
@inproceedings{ISMRM2018_4962,
annote={ISMRM2018_4962},
pages={4962},
file={ISMRM2018_4962.pdf:ISMRM2018_4962.pdf:PDF},
title={{ASL}-based f{MRI} phenotyping of high-anxiety Fischer rat strain reveals two unexpected sub-traits or -states: caveat for rodent studies},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4962.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Andreas Bruns and Thomas Mueggler and Markus von Kienlin and Basil Künnecke},
abstract={Fischer rats serve as a rodent model of high trait anxiety in neuroscience and drug discovery. Using ASL-based fMRI, we characterized Fischer rats with respect to their regional brain activity patterns and with reference to the standard Sprague-Dawley rat strain. Fischer rats clearly differed from Sprague-Dawley rats, but also split into two distinct subpopulations, with one showing a more deviant pattern than the other. Although it has remained elusive whether this is a trait or a state phenomenon, our data suggest that neuronal networks related to anxiety and/or depression are implicated.}
}
@inproceedings{ISMRM2018_4963,
annote={ISMRM2018_4963},
pages={4963},
file={ISMRM2018_4963.pdf:ISMRM2018_4963.pdf:PDF},
title={In utero monitoring of early embryonic mouse brain development and injury progression with localized diffusion {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4963.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Dan Wu and Jun Lei and Yan Zhu and Michael McLane and Irina Burd},
abstract={In utero diffusion MRI (dMRI) of the embryonic mouse brain is challenging due to maternal and fetal motions and limited resolution. We have previously developed a localized imaging technique and achieved fast dMRI of the live embryos. Here we explored the capacity of this technique to image embryonic mouse brains from mid-to-late gestation stages during development. Furthermore, we monitored the progression of embryonic brain injury in a mouse model of intrauterine inflammation. Our results suggested in utero dMRI is an indicator of fetal outcome after inflammatory injury and the embryonic brain injury correlates with placental injury in this animal model.}
}
@inproceedings{ISMRM2018_4964,
annote={ISMRM2018_4964},
pages={4964},
file={ISMRM2018_4964.pdf:ISMRM2018_4964.pdf:PDF},
title={Longitudinal voxel-based morphometry in juvenile zebra finch brains reveals volume changes linked to distinct stages of the critical period for song learning},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4964.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Julie Hamaide and Kristína Lukáčová and Geert De Groof and Johan Van Audekerke and Marleen Verhoye and Annemie Van der Linden},
abstract={We present an in vivo longitudinal MRI study that traces relative volume changes in the brain of juvenile male zebra finches from 20 to 200 days post hatching. In parallel, we also characterized song behavior to explore whether improvements in song performance can be linked to regional volume changes in the developing bird brain.}
}
@inproceedings{ISMRM2018_4965,
annote={ISMRM2018_4965},
pages={4965},
file={ISMRM2018_4965.pdf:ISMRM2018_4965.pdf:PDF},
title={Towards the Macaque Connectome: 24-Channel 3T Multi-Array Coil, {MR} Sequences and {HCP}-style Preprocessing},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4965.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Joonas Autio and Takayuki Ose and Masahiro Ohno and Yoshihiko Kawabata and Yuta Urushibata and Kantaro Nishigori and Masataka Yamaguchi and Yuki Hori and Atsushi Yoshida and Katsutoshi Murata and Matthew Glasser and Takuya Hayashi},
abstract={Macaque monkeys are an important neuroscientific model for understanding cortical organization of primates, yet non-human primate MRI applications have lagged behind those developed for humans. To address this issue, we developed a 24-channel receive coil for macaque brain imaging and adapted the Human Connectome Project (HCP)’s image acquisition protocols matched to monkey’s neuroanatomical resolution. By adapting HCP’s preprocessing methods for the macaque, we demonstrate that the resulting HCP-style monkey MRI data show great promise for multi-modal analyses of cortical architecture and connectivity, which have previously only been possible in humans.}
}
@inproceedings{ISMRM2018_4966,
annote={ISMRM2018_4966},
pages={4966},
file={ISMRM2018_4966.pdf:ISMRM2018_4966.pdf:PDF},
title={Orbitofrontal-limbic structural development maturation in non-human primates: a longitudinal study},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4966.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Akiko Uematsu and Junichi Hata and Yuji Komaki and Fumiko Seki and Chihoko Yamada and Norio Okahara and Yoko Kurotaki and Erika Sasaki and Hideyuki Okano},
abstract={We investigated typical orbitofront-limbic structural development of a non-human primate model, common marmoset, using longitudinal MRI data. Overall, robust volumetric growth was observed during infancy. This rapid brain volumetric growth was associated with the largest decrease in diffusivities of diffusion tensor imaging. That suggest that the volume increment result from an increase in the number and size of cells, dendrites and spines in the regions. In addition, our result suggested familial factors contributed the development of the orbitofrontal-limbic brain regions. Overall, this study provides further data on the factors and timing important for typical brain development.}
}
@inproceedings{ISMRM2018_4967,
annote={ISMRM2018_4967},
pages={4967},
file={ISMRM2018_4967.pdf:ISMRM2018_4967.pdf:PDF},
title={Assignment of Two More Fucose-α-(1-2)-Galactose Glycans in the Human Brain Linked in Animal Models to Learning and Memory},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4967.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Nathan Tosh and Scott Quadrelli and Graham Galloway and Carolyn Mountford},
abstract={Two-dimensional COSY scans at 3T using a 64 channel head and neck coil have enabled the inspection of fucose-α-(1-2)-galactose glycans that resonate in the region of F1=0.9-1.7ppm; F2= 4.1-4.5ppm. With accurate shimming and water suppression, two new peaks were identified (Fuc VI at 4.44-1.37 ppm and Fuc VII at 4.29-1.36 ppm). These cross-peaks were consistently visualised across 86 participants.}
}
@inproceedings{ISMRM2018_4968,
annote={ISMRM2018_4968},
pages={4968},
file={ISMRM2018_4968.pdf:ISMRM2018_4968.pdf:PDF},
title={Tomoelastography of the mouse brain by multifrequency single-shot {MR} elastography},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4968.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Gergely Bertalan and Jing Guo and Heiko Tzschätzsch and Charlotte Klein and Jürgen Braun and Ingolf Sack},
abstract={The overall aim of this study was to introduce in-vivo multifrequency single-shot MR elastography (MRE) for full-field-of-view stiffness mapping of mouse brain and to compare in-vivo stiffness of neural tissues featuring different white-to-gray matter ratios. Tomoelastography retrieves mouse brain stiffness with greater detail. The measured order of shear vave speed values indicates that white matter in the mouse brain is softer than gray matter within the examined frequency range from 900 to 1400 Hz.}
}
@inproceedings{ISMRM2018_4969,
annote={ISMRM2018_4969},
pages={4969},
file={ISMRM2018_4969.pdf:ISMRM2018_4969.pdf:PDF},
title={Synaptic Basis for Remodeling in the Mouse Somatosensory System Characterized by f{MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4969.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Emily Petrus and Galit Saar and Zhiwei Ma and Steve Dodd and Alan Koretsky},
abstract={Functional MRI (fMRI) is an effective tool to analyze brain activity, with research and clinical implications. Here we describe changes in fMRI stimulus evoked BOLD responses after unilateral whisker denervation in adult mice. These effects were mediated by specific synaptic remodeling in the whisker somatosensory system. Our results indicate that fMRI can detect circuit level changes in vivo, which can then be characterized at the synaptic level in vitro.}
}
@inproceedings{ISMRM2018_4970,
annote={ISMRM2018_4970},
pages={4970},
file={ISMRM2018_4970.pdf:ISMRM2018_4970.pdf:PDF},
title={Transient hyperhydration modulates the brain fluid distribution of spontaneous hypertension rats: A T2 relaxometry study},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4970.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Kun-I Chao and Xia-Yu Lyu and Pei-Lun Yu and Sheng-Min Huang and Shin-Lei Peng and Kung-Chu Ho and Ping-Huei Tsai and Fu-Nien Wang},
abstract={After 2\% of body weight fluid infusion, the homeostasis of fluid distribution was temporally modulated in spontaneously hypertensive rats, which is an animal model of neurodegenerative disease. After fluid infusion, shortened T2 showed in hippocampus and ventricles and prolonged T2 was in corpus callosum and amygdala. The analysis of T2 distribution with rNNLS showed that a component with T2 around 100-200ms was increased in both T2-altered regions. We attributed this component as a restricted interstitial fluid, which could be correlated to the function of glymphaticsystem. Therefore, our experiment may shed a light on functional imaging of glymphaticsystem.}
}
@inproceedings{ISMRM2018_4971,
annote={ISMRM2018_4971},
pages={4971},
file={ISMRM2018_4971.pdf:ISMRM2018_4971.pdf:PDF},
title={Comparison of white matter tracts between macaque and human brain},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4971.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Qinlin Yu and Fang Fang and Hao Huang},
abstract={White matter as the substrate of connectivity plays a critical role in brain evolution. However, the comprehensive tract-level comparison in morphology and microstructure between all common macaque and human white matter tracts has not been delineated. We aimed to qualitatively and quantitatively compare the tract-level microstructure and 3D pathways of corresponding white matter tracts between macaque and human brain using DTI measurements and tractography. Macaque white matter tract skeleton was obtained and comparison was conducted in five categorized tract groups. The differences are most prominent in association tracts with more extensive pathways and higher microstructural integrity in human brain association tracts.}
}
@inproceedings{ISMRM2018_4972,
annote={ISMRM2018_4972},
pages={4972},
file={ISMRM2018_4972.pdf:ISMRM2018_4972.pdf:PDF},
title={Lactate, the new hope against brain damages in neonatal hypoxia-ischemia},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4972.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Hélène Roumes and Ursule Dumont and Leslie Mazuel and Stéphane Sanchez and Jordy Blanc and Véronique Bouchaud and Jean-François Chateil and Anne-Karine Bouzier-Sore},
abstract={Hypoxia-ischemia remains a major perinatal mortality and chronic disability cause in newborns. Hypothermia is the only clinically therapeutic approach but new therapy must be developed. Our aim was to study the neuroprotective role of lactate in rat neonatal hypoxic-ischemic model and to determine the best pattern to counteract brain damages. Interestingly, lactate was much more neuroprotective when administered after hypoxia (curative) than before (preventive). Single versus 48h injection of lactate were compared. Lactate shows significant and important neuroprotection (ADC, FA, immunohistochemistry, behavioral studies).}
}
@inproceedings{ISMRM2018_4973,
annote={ISMRM2018_4973},
pages={4973},
file={ISMRM2018_4973.pdf:ISMRM2018_4973.pdf:PDF},
title={Mapping neurotransmitter variations upon water deprivation in rats using overlap-resolved {CEST}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4973.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Frederico Severo and Noam Shemesh},
abstract={Thirst regulation involves several brain regions and Glutamatergic/GABAergic mechanisms. Imaging those noninvasively could make a big impact on understanding brain circuitry in-vivo. A recently proposed method termed overlap-resolved CEST (orCEST) was suggested for mapping both Glutamate and GABA in the brain with increased specificity. Here, orCEST is used to investigate changes in these neurotransmitters in the rat brain in vivo upon water deprivation. Decreases in GABA and Glutamate in hypothalamic preoptic areas and corpus callosum, respectively, were observed in the Water Deprived group. This bodes well for future applications of orCEST for studying neurotransmission in-vivo.}
}
@inproceedings{ISMRM2018_4974,
annote={ISMRM2018_4974},
pages={4974},
file={ISMRM2018_4974.pdf:ISMRM2018_4974.pdf:PDF},
title={In Vivo Mapping and Quantification Approaches in Epileptic Seizure Rat Models Using Creatine Chemical Exchange Saturation Transfer (Cr{CEST}) Imaging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4974.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Dong-Hoon Lee and Do-Wan Lee and Jae-Im Kwon and Chul-Woong Woo and Sang-Tae Kim and Jin Seong Lee and Choong Gon Choi and Kyung Won Kim and Jeong Kon Kim and Dong-Cheol Woo},
abstract={CrCEST imaging is a novel imaging technique to provide in vivo image contrasts related with the changes of energy metabolism by creatine level changes. In this abstract, we attempted to evaluate signal changes in hippocampus at epileptic seizure rat models based on the quantified CrCEST signals. We also analyzed the correlations between CrCEST signals and PCr and PCr+Cr concentrations assessed by
1H-MRS spectra. Our results clearly showed that the CrCEST imaging can be a useful approach to evaluate the energy metabolism in hippocampus at epileptic seizure model and to provide the quantitative results that related with creatine level changes.}
}
@inproceedings{ISMRM2018_4975,
annote={ISMRM2018_4975},
pages={4975},
file={ISMRM2018_4975.pdf:ISMRM2018_4975.pdf:PDF},
title={Chemical Exchange Saturation Transfer Imaging of Glutamate (Glu{CEST}) in a Rat Model of Epilepsy using Proton Magnetic Resonance Spectroscopy (1H-{MRS}) at 7T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4975.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Do-Wan Lee and Jae-Im Kwon and Dong-Hoon Lee and Chul-Woong Woo and Sang-Tae Kim and Jin Seong Lee and Choong Gon Choi and Kyung Won Kim and Jeong Kon Kim and Dong-Cheol Woo},
abstract={Chemical exchange saturation transfer imaging of glutamate (GluCEST) is a novel magnetic resonance imaging (MRI) method for measuring brain glutamate (Glu) in humans and animals. In vivo quantification of neurotransmitter signals can provide insight into functional roles of brain structures and knowledge about biochemical compounds. This study, based on quantified GluCEST contrast values and
1H-MR spectral concentrations, assessed signal changes in control rats and rats with kainic acid-induced epileptic seizures and showed that in vivo GluCEST and
1H-MR spectral data can provide valuable information for interpreting changes in signals and concentrations of specific cerebral metabolites in kainic acid-induced rats.}
}
@inproceedings{ISMRM2018_4976,
annote={ISMRM2018_4976},
pages={4976},
file={ISMRM2018_4976.pdf:ISMRM2018_4976.pdf:PDF},
title={Correlations between brain metabolites and tau protein accumulation assessed by H-{MRS} and tau {PET} in Alzheimer’s disease model mice},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4976.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yuhei Takado and Hiroyuki Takuwa and Urushihata Takuya and Manami Takahashi and Maiko Ono and Jun Maeda and Masafumi Shimojo and Nobuhiro Nitta and Sayaka Shibata and Ichio Aoki and Naruhiko Sahara and Tetsuya Suhara and Makoto Higuchi},
abstract={Amyloid beta protein and tau proteins are two major hallmarks of the pathology of Alzheimer’s disease. To elucidate the relationship between brain metabolites and tau protein, we performed H-MRS and tau PET imaging of tauopathy mouse model (rTg4510). Five rTg4510 mice and five wild-type mice were scanned at the age of 4 and 6 months by H-MRS and tau PET. We demonstrated that the amount of tau had negative correlations with the amount of taurine, tNAA and glutamate, indicating that tau might reduce those metabolites selectively and caused neural impairment.}
}
@inproceedings{ISMRM2018_4977,
annote={ISMRM2018_4977},
pages={4977},
file={ISMRM2018_4977.pdf:ISMRM2018_4977.pdf:PDF},
title={Longitudinal evaluation of lesion pathology in a novel murine model for Multiple Sclerosis},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4977.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Caroline Guglielmetti and Christian Cordano and Ari Green and Myriam Chaumeil},
abstract={We used conventional MRI to longitudinally assess lesion pathology in a combined cuprizone and experimental autoimmune encephalomyelitis (CPZ/EAE) model. The novelty of this model lies in the recruitment of cells from the innate and adaptive immune system into brain lesions. We used T
2-weighted imaging to monitor white matter lesions. Interestingly, we showed a transient change in T
2 contrast at the onset of clinical symptoms in the CPZ/EAE group. Using gadolinium-enhanced MRI, we showed transient opening of the blood-brain-barrier prior and/or following clinical symptoms. Altogether, these findings are of relevance to understand the dynamics of lesion formation in a novel MS model.}
}
@inproceedings{ISMRM2018_4978,
annote={ISMRM2018_4978},
pages={4978},
file={ISMRM2018_4978.pdf:ISMRM2018_4978.pdf:PDF},
title={Anti-angiogenic treatment alters stiffness of glioblastoma in an orthotopic mouse model},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4978.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Katharina Schregel and Michal Oskar Nowicki and Miklos Palotai and Navid Nazari and Rachel Zane and Ralph Sinkus and Sean Lawler and Samuel Patz},
abstract={Glioblastoma (GBM) is the most common malignant brain tumor. As it is highly vascularized, anti-angiogenic treatment strategies have been tested. Such treatment hinders radiological tumor monitoring. Here, we probed the potential of magnetic resonance elastography (MRE) to evaluate GBM treated with anti-angiogenic therapy. GBM was orthotopically implanted in 10 nude mice, of which 5 were treated with B20 anti-VEGF antibody. MRI and MRE were performed repeatedly and brains were harvested for histology afterwards. Anti-angiogenic treatment slowed tumor growth, affected contrast-enhancement and slowed down tumor softening. The phase angle Y expressing the solid/liquid ratio appeared to indicate tumor progression.}
}
@inproceedings{ISMRM2018_4979,
annote={ISMRM2018_4979},
pages={4979},
file={ISMRM2018_4979.pdf:ISMRM2018_4979.pdf:PDF},
title={Fronto-striatal connectivity alterations in a prenatal ethanol exposure rat model: a resting-state functional {MRI} study},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4979.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Shiyu Tang and Su Xu and Jaylyn Waddell and Marie Hanscom and Wenjun Zhu and Rao Gullapalli and Sandra Mooney},
abstract={People with Fetal Alcohol Spectrum Disorders (FASDs) may present deficits in executive functions. The fronto-striatal circuit is a critical component of the fronto-basal ganglia pathway that plays an important role in executive processes. We used resting-state functional MRI to assess the effects of prenatal alcohol exposure on the functional interaction within the fronto-striatal circuit in a rat FASD model. Male alcohol-exposed rats, but not females, showed reduced fronto-striatal connectivity. Further exploratory analysis revealed a reduction in cortico-striatal connectivity in female alcohol-exposed rats, suggesting that prenatal alcohol exposure has sex dependent effects on executive and sensory processing functions.}
}
@inproceedings{ISMRM2018_4980,
annote={ISMRM2018_4980},
pages={4980},
file={ISMRM2018_4980.pdf:ISMRM2018_4980.pdf:PDF},
title={Longitudinal assessment of {TAT}-{PHP} treatment effect in improving brain function recovery from cardiac arrest resuscitation with endogenous perfusion using {ASL} and metabolic {CEST} {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4980.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Rong-Wen Tain and Chunpei Lee and Alessandro Scotti and Weiguo Li and Xiangdong Zhu and Terry L. Vanden Hoek and Jing Li and Kejia Cai},
abstract={Sudden cardiac arrest is a leading cause of death in the US. A recently developed peptide-based (TAT-PHP) therapy has been shown to improve survival rate and heart metabolism in animal studies. There is a great need to evaluate the effect of the treatment in the brain as the brain is the most susceptible organ following cardiac arrest. We here demonstrated that the recovery of brain perfusion and metabolism is improved in mice with TAT-PHP treatment vs. controls with endogenous perfusion arterial spin labeling MRI and metabolic MRI based on chemical exchange saturation transfer.}
}
@inproceedings{ISMRM2018_4981,
annote={ISMRM2018_4981},
pages={4981},
file={ISMRM2018_4981.pdf:ISMRM2018_4981.pdf:PDF},
title={Longitudinal evaluation of iron load with quantitative suceptibility mapping ({QSM}) in a primate model of Parkinson's disease},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4981.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Mathieu David Santin and Maxime Verdier and Romain Valabregue and Elodie Laffrat and Lydia Yahia Cherif and Alexandra Petiet and Stéphane Lehéricy and Stéphane Hunot},
abstract={In this study, we performed a longitudinal follow-up of iron load in a primate model of Parkinson's disease using both QSM and R2* mapping. ROI definition was automatically performed using an in-house template computed from all acquired data. Statistical analyses revealed that QSM is more sensitive to model-induced variation in iron-rich regions compared to R2* mapping.}
}
@inproceedings{ISMRM2018_4982,
annote={ISMRM2018_4982},
pages={4982},
file={ISMRM2018_4982.pdf:ISMRM2018_4982.pdf:PDF},
title={Optical Coherent Tomography ({OCT}) Detected Axonal Loss but Failed to Identify Acute Axonal Injury: A Diffusion Study},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4982.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Tsen-Hsuan (Abby) Lin and Ying-Bo Shui and Ying Liu and Hsin-Chieh Yang and Michael Wallendorf and Carla J Siegfriedand and Sheng-Kwei Song},
abstract={Optical coherence tomography (OCT) is widely used to noninvasively assess retinal nerve fiber layer (RNFL) thickness to assess optic nerve damage. However, the impact of coexisting pathology on OCT-detected RNFL thickness remains unclear. We have previously developed a diffusion basis spectrum imaging (DBSI) to directly assess coexisting pathologies in mouse models of optic nerve crush (ONC) and optic neuritis. In the current study, we assessed retinal pathology and coexisting pathologies in optic nerve of ONC mice longitudinally, with OCT and DBSI, respectively. Our goal is to determine the relationship between OCT-detected RNFL change and DBSI-derived optic nerve pathologies.}
}
@inproceedings{ISMRM2018_4983,
annote={ISMRM2018_4983},
pages={4983},
file={ISMRM2018_4983.pdf:ISMRM2018_4983.pdf:PDF},
title={Diffusion Basis Spectrum Imaging ({DBSI}): Successful in vivo Use to Assess Axonal Protection in Mouse Optic Neuritis treated with Fingolimod},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4983.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Tsen-Hsuan (Abby) Lin and Rui-Meng Yang and Jie Zhan and Chunyu Song and Peng Sun and Michael Wallendorf and Anne H Cross and Sheng-Kwei Song},
abstract={We previously introduced diffusion basis spectrum imaging (DBSI) to noninvasively assess coexisting pathologies in central nervous system (CNS) tissues.Previously, we showed in multiple sclerosis (MS) spinal cord specimens and mice with experimental autoimmune encephalomyelitis (EAE), the main animal model of MS, that DBSI reflected coexisting white matter pathologies in CNS. Fingolimod, a disease-modifying treatment approved for relapsing MS, is thought to preserve axons. In the current study, we employed longitudinal DBSI to noninvasively assess fingolimod treatment efficacy in EAE mouse optic nerve, followed by histological validation.}
}
@inproceedings{ISMRM2018_4984,
annote={ISMRM2018_4984},
pages={4984},
file={ISMRM2018_4984.pdf:ISMRM2018_4984.pdf:PDF},
title={Protein Aggregation in Mouse Brain with Alzheimer's Disease Revealed by Saturation Transfer {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4984.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Lin Chen and Zhiliang Wei and Kannie Chan and Shuhui Cai and Guanshu Liu and Hanzhang Lu and Philip C. Wong and Peter C.M. van Zijl and Tong Li and Jiadi Xu},
abstract={This study aims to detect the aggregated proteins involved in Alzheimer's Disease (AD) using chemical exchange saturation transfer (CEST) as a potential strategy for early diagnosis of the disease. A radial ultra-short echo time (UTE) image acquisition scheme was applied to map CEST signals with sufficient sensitivity and robustness to motion. Studies on cross-linked bovine serum albumin (BSA) and an AD transgenic model (mutant APP/PS1 mouse) demonstrated that the saturation transfer (ST) signal at -3.6 ppm, which is a combination of relayed nuclear Overhauser enhancement (rNOE)-CEST and a small portion of magnetization transfer contrast (MTC), can be used a potential biomarker for monitoring changes in brains of a mouse model of AD.}
}
@inproceedings{ISMRM2018_4985,
annote={ISMRM2018_4985},
pages={4985},
file={ISMRM2018_4985.pdf:ISMRM2018_4985.pdf:PDF},
title={Atlas-based and voxel-based symptom mapping to explore anatomical substrates of functional recovery after stroke in the mouse},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4985.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Stefan Paul Koch and Felix Knab and Ulrike Grittner and René Bernard and Susanne Mueller and Marco Foddis and Janet Lips and Philipp Euskirchen and Norman Zerbe and Peter Hufnagl and André Rex and Ulrich Dirnagl and Tracy Deanne Farr and Christoph Harms and Philipp Boehm-Sturm},
abstract={Post-stroke functional recovery remains a poorly understood process. We aimed to identify anatomical regions that statistically explain a deficit in the staircase test after stroke in the mouse using two animal models (MCAO, photothrombosis). MATLAB toolboxes are presented for co-registration of MRI and histology data to the Allen brain atlas and implementation of atlas region-wise or voxel-wise mapping of behavioral deficits. Automatic techniques are shown for validation of MRI results on stained tissue sections.
}
}
@inproceedings{ISMRM2018_4986,
annote={ISMRM2018_4986},
pages={4986},
file={ISMRM2018_4986.pdf:ISMRM2018_4986.pdf:PDF},
title={True Phase Quantitative Susceptibility Mapping Using Continuous Single Point Imaging: A Feasibility Study},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4986.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Hyungseok Jang and Xing Lu and Eric Y Chang and Jiang Du},
abstract={Quantitative susceptibility mapping (QSM) has recently been in the limelight as a novel contrast mechanism to provide quantification of apparent magnetic susceptibility based on phase information in MR images. In this study, we explore feasibility of single point imaging (SPI) for QSM. SPI, also known as constant time encoding or pure phase encoding, provides true phase information not affected by phase evolution during readout, which is beneficial for accurate QSM. We propose a new and efficient SPI acquisition scheme for QSM, termed Continuous SPI, where SPI images are continuously obtained with extremely high temporal resolution in a single scan.}
}
@inproceedings{ISMRM2018_4987,
annote={ISMRM2018_4987},
pages={4987},
file={ISMRM2018_4987.pdf:ISMRM2018_4987.pdf:PDF},
title={Quantitative {MRI} and laser ablation-inductively coupled plasma-mass spectrometry imaging of iron in post-mortem frontal cortex of Alzheimer patients},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4987.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Marjolein Bulk and Walid M. Abdelmoula and Wim Wiarda and Itamar Ronen and Jouke Dijkstra and Louise van der Weerd},
abstract={Previous imaging studies reported iron-induced T2* or phase contrast changes in the cortex of post-mortem brain tissue of patients with Alzheimer’s disease (AD), but comparison with a gold standard is lacking. This study used laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) as a gold standard for iron in post-mortem brain tissue of controls and AD patients and investigated the correlation between LA-ICP-MS, quantitative MRI (R2*, phase and QSM) and histology. R2* and QSM showed the highest correlation with iron content; the correlation of phase with iron was weaker, probably due to its high orientation dependence.}
}
@inproceedings{ISMRM2018_4988,
annote={ISMRM2018_4988},
pages={4988},
file={ISMRM2018_4988.pdf:ISMRM2018_4988.pdf:PDF},
title={Fat Correction of {MRI} Phase Images for Accurate Susceptibility Mapping in the Head and Neck},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4988.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Anita Karsa and Shonit Punwani and Karin Shmueli},
abstract={Susceptibility Mapping (QSM) is increasingly applied in parts of the body where fatty tissue is present. QSM uses the phase of the complex MRI signal which contains both susceptibility- and chemical-shift-induced components. For accurate QSM, the latter need to be suppressed. Here we compared a range of different fat-correction strategies for QSM in head-and-neck images. Techniques providing reliable fat-fraction maps also gave similar susceptibility values in fatty fascia. However, some of these methods were not robust to the choice of echo times. In-phase imaging was found to be the best candidate for robust fat-correction in QSM of the head-and-neck.}
}
@inproceedings{ISMRM2018_4989,
annote={ISMRM2018_4989},
pages={4989},
file={ISMRM2018_4989.pdf:ISMRM2018_4989.pdf:PDF},
title={Bone Marrow Susceptibility as a Marker of Bone Mineral Density in Spondyloarthritis},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4989.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Anita Karsa and Timothy J.P. Bray and Alan Bainbridge and Shonit Punwani and Margaret A. Hall-Craggs and Karin Shmueli},
abstract={New bone formation (causing spinal fusion) and bone loss are both key features of spondyloarthritis and contribute to significant morbidity and disability. However, these processes are difficult to monitor using conventional MRI, which provides minimal information about bone mineral density (BMD). Here, we show that bone marrow susceptibility can be used as a marker of BMD, using data from a fat-water-bone phantom and from subjects with spondyloarthritis. Susceptibility values are significantly increased in areas of fat metaplasia compared to normal marrow, suggesting that this lesion represents a form of local bone loss, which could be monitored using susceptibility mapping.}
}
@inproceedings{ISMRM2018_4990,
annote={ISMRM2018_4990},
pages={4990},
file={ISMRM2018_4990.pdf:ISMRM2018_4990.pdf:PDF},
title={Whole Brain Background Field Removal using Spherical Mean Value Filtering and Local Polynomial Approximation for Quantitative Susceptibility Mapping},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4990.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Toru Shirai and Ryota Sato and Takenori Murase and Yoshitaka Bito and Hisaaki Ochi},
abstract={We propose a novel background-field removal method to recover a local field of a brain edge. The proposed method consists of two steps. First, the background field of the brain edge is calculated from the total field by using local polynomial approximation. Second, the local field of the whole brain is calculated by regularization that enables sophisticated harmonic artifacts reduction for phase data (RESHARP) processing with the constraint term of the background field of the brain edge. The results from a human brain experiment showed that the method is useful for calculating the local field and susceptibility maps of the whole brain.}
}
@inproceedings{ISMRM2018_4991,
annote={ISMRM2018_4991},
pages={4991},
file={ISMRM2018_4991.pdf:ISMRM2018_4991.pdf:PDF},
title={High resolution frequency difference mapping using {ASPIRE} phase combination},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4991.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Korbinian Eckstein and Siegfried Trattnig and Simon Daniel Robinson},
abstract={Frequency difference mapping (FDM) is a promising new method for investigating tissue microstructure. To date, images have been of quite low resolution and noise because of the need to use monopolar readout and two difference operations. We propose an improved approach – ASPIRE-FDM – which is based on a recently developed coil combination method which removes both phase offsets and phase gradients in readout direction in more efficient bipolar acquisitions. The resulting maps have drastically reduced noise and make feasible a four-fold reduction in voxel volume compared to prior work.}
}
@inproceedings{ISMRM2018_4992,
annote={ISMRM2018_4992},
pages={4992},
file={ISMRM2018_4992.pdf:ISMRM2018_4992.pdf:PDF},
title={An assessment of the ‘Prescan-Normalize Adaptive Combine’ approach to combining phase images from multi-channel coils at 3T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4992.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Korbinian Eckstein and Siegfried Trattnig and Simon Daniel Robinson},
abstract={The combination of data acquired with array coils often leads to phase artifacts. The recently-introduced method ‘Prescan-Normalize Adaptive Combine’ (PN-AC) is assessed in terms of non-ΔB
0-related contributions and reproducibility with different head positions and compared with a robust multi-echo phase combination approach (called ASPIRE) which yields only ΔB
0-related phase. PN-AC was found to generate low noise phase images but introduce non-ΔB
0-related contributions to the combined phase. It was robust to motion between the prescan and the main acquisition other than the introduction of arbitrary background phase.}
}
@inproceedings{ISMRM2018_4993,
annote={ISMRM2018_4993},
pages={4993},
file={ISMRM2018_4993.pdf:ISMRM2018_4993.pdf:PDF},
title={Multi-channel phase combination for quantitative susceptibility mapping at 7T using Phase-Offsets Estimation from Multi-echoes ({POEM}) method},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4993.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Hongfu Sun and Jon O. Cleary and Rebecca Glarin and Scott Kolbe and Bradford A. Moffat and Roger J. Ordidge and G. Bruce Pike},
abstract={A Phase-Offsets Estimation from Multi-echoes (POEM) method is proposed to combined the phase-arrayed coil at 7T for quantitative susceptibility mapping (QSM). The method demonstrates equivalent or better results than adding a conventional reference scan for both single-orientation and multi-orientation QSM.}
}
@inproceedings{ISMRM2018_4994,
annote={ISMRM2018_4994},
pages={4994},
file={ISMRM2018_4994.pdf:ISMRM2018_4994.pdf:PDF},
title={Extracting more: Multi-echo {MP}2{RAGE} at 7T enables simultaneous T1w, quantitative T1, T2* and susceptibility mapping from a single acquisition},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4994.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Hongfu Sun and Jon O. Cleary and Rebecca Glarin and Yuhan Ma and Kieran O'Brien and Scott Kolbe and Bradford A. Moffat and Roger J. Ordidge and G. Bruce Pike},
abstract={We demonstrate the feasibility of extracting simultaneous T1w, quantitative T1, T2* and susceptibility mapping from a single Multi-echo MP2RAGE scan of 10min at 7T. After optimizing the multi-channel phase combination, QSM from the Multi-echo MP2RAGE is comparable to that from a standard GRE sequence, with the benefits of additional parametric maps.}
}
@inproceedings{ISMRM2018_4995,
annote={ISMRM2018_4995},
pages={4995},
file={ISMRM2018_4995.pdf:ISMRM2018_4995.pdf:PDF},
title={Shading Artifact Suppression using Relaxation Map and Machine Learning-based Region Detection for Quantitative Susceptibility Mapping},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4995.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Taichiro Shiodera and Takashi Watanabe and Tomoyuki Takeguchi and Naotaka Sakashita and Masao Yui and Samir D. Sharma},
abstract={We propose a dipole inversion method for improving quantitative susceptibility mapping. In conventional methods, shading artifacts often occur near the longitudinal fissure (LF) region of the estimated susceptibility map. Here, we propose an algorithm for LF region detection and regularized inversion, to reduce the shading artifacts. The LF region is automatically detected using information from the T2* map as well as training datasets via machine learning. The proposed method eliminates shading artifacts near the LF region in the susceptibility maps, while also showing negligible change in regions that do not suffer from shading artifacts, such as the basal ganglia.}
}
@inproceedings{ISMRM2018_4996,
annote={ISMRM2018_4996},
pages={4996},
file={ISMRM2018_4996.pdf:ISMRM2018_4996.pdf:PDF},
title={Considerations in Quantitative Susceptibility Mapping using Echo Planar Imaging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4996.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Beata Bachrata and Korbinian Eckstein and Siegfried Trattning and Simon Daniel Robinson},
abstract={Phase images from EPI and GE acquisitions differ due to the divergent acquisition schemes and reconstruction steps. The effect of these is investigated both in measured phase and estimated susceptibility values. We show that non-ΔB
0-related phase is present in phased array data combined with the Virtual Receiver Coil and Roemer approaches and that this influences estimated susceptibilities. For EPI, data can be combined using a multi-echo “ASPIRE” GE prescan, leading to minimal non-ΔB
0-related phase. There was large variability of in-vivo EPI fieldmaps due to physiological noise and non-linearities in phase evolution in both GE and EPI data.}
}
@inproceedings{ISMRM2018_4997,
annote={ISMRM2018_4997},
pages={4997},
file={ISMRM2018_4997.pdf:ISMRM2018_4997.pdf:PDF},
title={Accelerating 3D whole brain quantitative susceptibility mapping acquisition using compressed sensing},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4997.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Nian Wang and Gary Cofer and Yi Qi and G. Allan Johnson},
abstract={To evaluate the feasibility of compressed sensing (CS) for accelerating quantitative susceptibility mapping (QSM) acquisition at a high spatial resolution in mouse brains (22.5 μm
3, isotropic). This preliminary study shows that CS can be applied to significantly reduce the acquisition time of GRE MRI of mice brains at 9.4 T without losing apparent accuracy in quantitative susceptibility values.}
}
@inproceedings{ISMRM2018_4998,
annote={ISMRM2018_4998},
pages={4998},
file={ISMRM2018_4998.pdf:ISMRM2018_4998.pdf:PDF},
title={Simultaneous Analyses and Reconstruction of Quantitative Susceptibility Mapping and Voxel-based Morphometry Using Magnetization-prepared Spoiled Turbo Multiple Gradient Echo},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4998.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Hirohito Kan and Nobuyuki Arai and Satoshi Tsubokura and Masato Yamada and Yuta Nishiwaki and Kyosuke Mizuno and Harumasa Kasai and Yasujiro Hirose and Yuta Shibamoto},
abstract={Quantitative susceptibility mapping (QSM) and voxel-based morphometry (VBM) analyses are helpful in detecting an abnormal iron overload and the regional change of volume in the gray and white matters, respectively. This abstract presents a novel method for simultaneous analyses of QSM and VBM using magnetization-prepared spoiled turbo multiple gradient echo sequence with inversion pulse for QSM sequence which provides 3D T1-weighted structural images for VBM and multi-echo phase images for QSM on single scan.}
}
@inproceedings{ISMRM2018_4999,
annote={ISMRM2018_4999},
pages={4999},
file={ISMRM2018_4999.pdf:ISMRM2018_4999.pdf:PDF},
title={A multi-scale approach to quantitative susceptibility mapping ({MSDI})},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/4999.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Julio Acosta-Cabronero and Carlos Milovic and Cristian Tejos and Martina F Callaghan},
abstract={We propose a new QSM algorithm, namely multi-scale dipole inversion (MSDI), which builds on the nonlinear MEDI (nMEDI) framework incorporating two additional features: (i) improved error control through dynamic phase-reliability compensation across harmonic scales and (ii) scale-specific use of the morphological prior. MSDI is the first algorithm to rank in the top-10 for all performance metrics evaluated in the 2016 QSM Reconstruction Challenge. It also demonstrates lower variance than nMEDI in a reproducibility test.}
}
@inproceedings{ISMRM2018_5000,
annote={ISMRM2018_5000},
pages={5000},
file={ISMRM2018_5000.pdf:ISMRM2018_5000.pdf:PDF},
title={Quantitative susceptibility mapping Accelerated Reconstruction Technique ({QUART}): A novel Split Bregman based approach for rapid reconstruction of quantitative susceptibility maps},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5000.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Srikant Kamesh Iyer and Brianna F. Moon and Walter R.T. Witschey},
abstract={This abstract presents a novel Split Bregman (SB) based approach to enable rapid minimization of the quantitative susceptibility reconstruction formulation that includes a weighted least squares fidelity constraint and a total variation (TV) penalty. The purpose of this approach is to develop a rapid minimization technique that does not need complex matrix factorization or computation of matrix preconditioners to accelerate convergence. Rapid minimization is achieved by the application of two variable substitutions, one to the weighted fidelity constraint and the other to the total variation term. Minimization of the cost functional is achieved by the novel combination of FISTA based iterative re-weighting and soft thresholding.}
}
@inproceedings{ISMRM2018_5001,
annote={ISMRM2018_5001},
pages={5001},
file={ISMRM2018_5001.pdf:ISMRM2018_5001.pdf:PDF},
title={Reducing Streaking Artifacts in Quantitative Susceptibility Mapping via Deep Learning},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5001.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jie Liu and Yida Wang and Yang Song and Haibin Xie and Jianqi Li and Guang Yang},
abstract={In this study, we proposed a new approach to reduce streaking artifacts in quantitative susceptibility mapping via deep learning. It combined two convolutional neural networks to reduce streaking artifacts from classic threshold-based k-space division (TKD) . The proposed method achieved impressive performance both visually and statistically.}
}
@inproceedings{ISMRM2018_5002,
annote={ISMRM2018_5002},
pages={5002},
file={ISMRM2018_5002.pdf:ISMRM2018_5002.pdf:PDF},
title={Susceptibility-Weighted Imaging on a Compact 3T Scanner with High-Performance Gradients},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5002.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yunhong Shu and Shengzhen Tao and MyungHo In and Joshua D Trzasko and Erin Gray and John Huston III and Matt A Bernstein},
abstract={Susceptibility-weighted imaging (SWI) uses a 3D multi-echo gradient-echo sequence with unipolar gradient lobes to acquire all echoes, with fly-back gradients inserted in-between. These fly-back gradients reduce acquisition efficiency and increase echo spacing. We demonstrated that the high gradient performance available on a compact 3T system can reduce the echo spacing in the multi-echo readout by reducing the pulse-width of the fly-back gradient, which consequently allows a greater number of echoes to be sampled. The increased number of echoes translates into reduced noise and improved small vessel conspicuity in SWI acquired on the compact 3T compared to the conventional whole-body system.}
}
@inproceedings{ISMRM2018_5003,
annote={ISMRM2018_5003},
pages={5003},
file={ISMRM2018_5003.pdf:ISMRM2018_5003.pdf:PDF},
title={Quantitative Susceptibility Mapping of Articular Cartilage in Patients with Osteoarthritis},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5003.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Hongjiang Wei and Huimin Lin and Yuyao Zhang and Weibo Chen and Fuhua Yan and Chunlei Liu},
abstract={Osteoarthritis (OA) is a multifactorial degenerative joint disease and is the most common form of arthritis which characterized by degenerative changes in the cartilage, menisci, ligamentsand bone. The purpose of this study is to evaluate the magnetic susceptibility changes in knee diseases, such as patients with bone marrow lesions and cartilage loss. Clear susceptibility contrast was observed between bone marrow lesions and surroundings. The multilayer pattern of the damaged cartilage was lost compared with that of healthy subjects. QSM may provide a new way to improve the characterization of tissue microstructure in the knee joint related to osteoarthritis.}
}
@inproceedings{ISMRM2018_5004,
annote={ISMRM2018_5004},
pages={5004},
file={ISMRM2018_5004.pdf:ISMRM2018_5004.pdf:PDF},
title={{GRE} Phase Contrast of the Brain at Ultra-Short {TE} in Patients with Multiple Sclerosis},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5004.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Hongjiang Wei and Peng Cao and Roland Henry and Peder Larson and Chunlei Liu},
abstract={The purpose of this study was to determine whether gradient-echo proton images of the brain exhibit any phase contrast at UTE and whether this contrast can be used to improve the characterization of tissue microstructure in the brain. Our data demonstrated that UTE images of the brain can attain strong phase contrast even at a TE of 226ms by using off-resonance RF pulses for selective saturation. UTE phase in an MS patient shows a strong contrast with surrounding white matters.}
}
@inproceedings{ISMRM2018_5005,
annote={ISMRM2018_5005},
pages={5005},
file={ISMRM2018_5005.pdf:ISMRM2018_5005.pdf:PDF},
title={Imaging Human Brain Cortical Substructure with Quantitative Susceptibility Mapping at 7 T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5005.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Hongjiang Wei and Berkin Bilgic and Kawin Setsompop and Boris Keil and David Feinberg and Chunlei Liu},
abstract={High-field MRI combined with high-density motor-cortex coil and a novel QSM algorithm allows in vivo brain cortex imaging with high contrast-to-noise ratio and spatial resolution (0.15x0.15x0.65 mm
3). Our work revealed up to six apparent myelin/iron layers in humancortex in vivo determined by the underlying magnetic susceptibility and complex vasculature in the cortical areas. Cortical susceptibility imaging provides high-resolution quantitative measurements of cortical cytoarchitecture and vasculature.}
}
@inproceedings{ISMRM2018_5006,
annote={ISMRM2018_5006},
pages={5006},
file={ISMRM2018_5006.pdf:ISMRM2018_5006.pdf:PDF},
title={In vivo quantitative susceptibility mapping detection of β-amyloid targeted by curcumin-conjugated magnetic nanoparticles},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5006.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Celia M. Dong and Mengye Lyu and Anthea To and Ed X. Wu},
abstract={At present, there is a lack of reliable in vivo diagnostic methods to visualize and quantify the Alzheimer's disease (AD) pathologies. β-amyloid (Aβ) plaques are the hallmarks of AD brains. Recently, we have designed a novel curcumin-conjugated magnetic nanoparticles (Cur-MNPs) that target Aβ pathologies. Quantitative susceptibility mapping (QSM) offers the possibility of quantifying Cur-MNPs in vivo as a quantitative surrogate marker for Aβ pathologies. In this study, we optimized the QSM acquisition and processing procedure for mouse brains in vivo. Furthermore, we investigated the ability of QSM in detecting Cur-MNPs targeted Aβ pathologies in vivo in transgenic AD mouse models.}
}
@inproceedings{ISMRM2018_5007,
annote={ISMRM2018_5007},
pages={5007},
file={ISMRM2018_5007.pdf:ISMRM2018_5007.pdf:PDF},
title={Quantitative assessment of melanoma metastases at 7T: Susceptibility and T1 mapping},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5007.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Sina Straub and Frederik B. Laun and Martin T. Freitag and Heinz-Peter Schlemmer and Mark E. Ladd and Till M. Schneider},
abstract={Susceptibility values and T1 values of melanoma metastases measured at 7T are shown. There is an ongoing discussion about whether melanin or hemorrhage dominate the contrast mechanisms observed in melanoma metastases. Susceptibility maps as well as T1 maps benefit from the high contrast and high resolution available at 7T, though we observed paramagnetic susceptibility in areas corresponding to vessels or hemorrhagic events, but no general relation between susceptibility values and T1 values of individual metastases}
}
@inproceedings{ISMRM2018_5008,
annote={ISMRM2018_5008},
pages={5008},
file={ISMRM2018_5008.pdf:ISMRM2018_5008.pdf:PDF},
title={Clinical Implementation of Quantitative Susceptibility Mapping: Experience Across Multiple Sites and Scanner Platforms.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5008.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Pascal Spincemaille and Zhe Liu and Shun Zhang and Matteo Ippoliti and Marcus Makowski and Richard Watts and Ludovic de Rochefort and Vijay Venkatraman and Patricia Desmond and Brian Kopell and Patrice Péran and Yi Wang},
abstract={In recent years, quantitative susceptibility mapping (QSM) has undergone a series of technical improvements and found applications in an expanding array of diseases. To support this ongoing process of development and validation, it is important to automate the computationally intensive susceptibility reconstruction on the scanner after the acquisition of gradient echo data. In this work, an online QSM reconstruction system for a variety of scanner platforms with low cross-site ROI standard deviation is demonstrated.}
}
@inproceedings{ISMRM2018_5009,
annote={ISMRM2018_5009},
pages={5009},
file={ISMRM2018_5009.pdf:ISMRM2018_5009.pdf:PDF},
title={Multi-site reproducibility of quantitative susceptibility mapping at 1.5, 3 and 7T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5009.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Kofi M Deh and Keigo Kawaji and Deb Horng and Marjolein Bulk and Louise Van Der Weerd and Pascal Spincemaille and Thanh Nguyen and Yi Wang},
abstract={Quantitative susceptibility mapping (QSM) is increasingly being applied to quantitative research on disease conditions including intracerebral hemorrhage, liver iron overload and bone mineral quantification. These applications require knowledge of the reproducibility of QSM of sources with high susceptibility, which has not been previously reported. Here, we investigate the agreement between QSM maps generated from gradient-echo scans acquired at multiple sites using multiple platforms.
}
}
@inproceedings{ISMRM2018_5010,
annote={ISMRM2018_5010},
pages={5010},
file={ISMRM2018_5010.pdf:ISMRM2018_5010.pdf:PDF},
title={Gadoxetate relaxivities increase significantly after hepatic uptake at clinical field strength impacting kinetic modelling for liver function analysis},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5010.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Gregor Jost and Gunnar Schuetz and Hubertus Pietsch},
abstract={Schuhmann-Giampieri1 reported r1 of gadoxetate to be significantly higher in liver tissue compared to blood at 0.47T. Gadoxetate relaxivities at 1.5T, 3T and 4.7T have since then been reported for water and plasma2, but not hepatocytes. We here present r1 values for gadoxetate in hepatocytes at 1.5T and 3T to complement existing data. r1 values of gadoxetate after uptake into hepatocytes are about 2x higher compared to blood. There is no relevant field strength dependency over a wide range (0.47T - 3T). This has implications on kinetic modelling of dynamic gadoxetate enhanced MRI data for determination of liver transporter activity.}
}
@inproceedings{ISMRM2018_5011,
annote={ISMRM2018_5011},
pages={5011},
file={ISMRM2018_5011.pdf:ISMRM2018_5011.pdf:PDF},
title={Exploring the Origin of Asymmetries in the Balanced {SSFP} Profile at 9.4 Tesla: Microstructure Anisotropy or Chemical Exchange?},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5011.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Rahel Heule and Moritz Zaiss and Philipp Ehses and Klaus Scheffler},
abstract={The balanced steady-state free precession (bSSFP) profile is known to carry information about the tissue-dependent frequency content in a voxel. There has been strong evidence that the observed asymmetries in the bSSFP profile of white matter depend on the tract orientation with the largest asymmetries occurring in tracts perpendicular to B
0. Recently, it was demonstrated that the bSSFP sequence can be used for chemical exchange detection based on profile asymmetries arising in isotropic probes of two exchanging pools. In this work, we explore the question whether exchanging species might contribute to the bSSFP profile asymmetry observed in white matter.}
}
@inproceedings{ISMRM2018_5012,
annote={ISMRM2018_5012},
pages={5012},
file={ISMRM2018_5012.pdf:ISMRM2018_5012.pdf:PDF},
title={Towards Quantification of Manganese Deposition in the Human Brain in the Presence of Iron: A Calibration Study},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5012.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Chien-Lin Yeh and Ulrike Dydak},
abstract={Welders are exposed to high levels of manganese (Mn) and iron (Fe). Since Mn is neurotoxic, being able to quantify brain Mn deposition by MRI is of high interest. This phantom calibration study is a first step towards understanding the combined effect of Mn and Fe on R1. Our results show that the presence of serum in the solution requires a Mn-Fe interaction term to improve the fit, likely due to the competing binding to the protein. The presence of Fe reduces the R1 effect of pure Mn, which would lead to an underestimation of brain Mn if Fe was neglected.}
}
@inproceedings{ISMRM2018_5013,
annote={ISMRM2018_5013},
pages={5013},
file={ISMRM2018_5013.pdf:ISMRM2018_5013.pdf:PDF},
title={Comparison of B0 versus B0 and B1 field inhomogeneity correction for glycosaminoglycan chemical exchange saturation transfer imaging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5013.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Anja Müller-Lutz and Alexandra Ljimani and Julia Stabinska and Hans-Jörg Wittsack and Christoph Schleich},
abstract={Glycosaminoglycan CEST (gagCEST) has been shown to be a useful tool for assessing changes in glycosaminoglycan concentrations in cartilage. However, accurate B0 referencing is necessary for observing reliable gagCEST. Here we investigate whether the quality of in vivo gagCEST images can be further improved by correction of both B0 and B1 inhomogeneity by using a novel water shift and B1 (WASABI) mapping method. We present results from 20 healthy volunteers acquired at 3T. A comparison with the outcome of WASSR B0 mapping shows that the application of the WASABI maps to inhomogeneity artefact correction is advantageous to gagCEST imaging.}
}
@inproceedings{ISMRM2018_5014,
annote={ISMRM2018_5014},
pages={5014},
file={ISMRM2018_5014.pdf:ISMRM2018_5014.pdf:PDF},
title={Dephasing and diffusion in blood vessel networks: an exact solution of the Bloch-Torrey-equation},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5014.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Lukas R. Buschle and Felix T. Kurz and Heinz-Peter Schlemmer and Christian H. Ziener},
abstract={The relaxation in blood vessel networks depends on susceptibility and diffusion effects around vessels. In 1994, Yablonskiy and Haacke developed a geometrical model of vessels and analyzed the gradient echo signal for negligible diffusion. Many approximative methods were developed generalizing this model in the limits of small and large diffusion effects. Important methods like vessel size or architectural imaging are based on these works. Here, we provide an exact solution of the Bloch-Torrey-equation in the model of Yablonskiy and Haacke for arbitrary diffusion effects that allows a validation of previously developed methods.}
}
@inproceedings{ISMRM2018_5015,
annote={ISMRM2018_5015},
pages={5015},
file={ISMRM2018_5015.pdf:ISMRM2018_5015.pdf:PDF},
title={An improved blood pool {MRI} agent with dinuclear structure: characterization and in vivo bio-distribution},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5015.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Alberto Fringuello Mingo and Francesca La Cava and Luigi Miragoli and Enzo Terreno and Enrico Cappelletti and Luciano Lattuada and Sonia Colombo Serra and Luisa Poggi and Fabio Tedoldi},
abstract={A novel dinuclear gadolinium(III) chelate containing two moieties of DTPA, covalently conjugated to deoxycholic acid is presented. The product was synthesized and characterized in vitro (analysis of relaxometric properties in different media) and in vivo (blood pharmacokinetic and MRI bio-distribution). The complex showed a much higher relaxivity than Gd-DTPA and other dinuclear complexes proposed in literature. Moreover, it displayed a strong interaction with human serum albumin in three binding sites. This property translates in a long blood elimination half time (130min in rats) making the product an optimal blood-pool agent.}
}
@inproceedings{ISMRM2018_5016,
annote={ISMRM2018_5016},
pages={5016},
file={ISMRM2018_5016.pdf:ISMRM2018_5016.pdf:PDF},
title={Comparison of cardiac output calculated from low dose Ultra-fast {DCE} {MRI} to the values measured from cardiac {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5016.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Shiyang Wang and Yue Zhang and Xiaobing Fan and Dianning He and Milica Medved and Tatjana Antic and Ambereen Yousuf and Gregory Karczmar and Aytekin Oto},
abstract={Accurately measuring arterial input function (AIF) is essential for quantitative dynamic contrast enhanced (DCE) MRI. The indicator dilution principle was used to verify the accuracy of AIF measured at iliac arties following injection of low dose (0.015 mmol/kg) gadolinium contrast media. The cardiac output from cardiac MRI (CO
CMRI) were compared with the cardiac output from Ultra-fast DCE-MRI (CO
DCE). Results demonstrated that the CO
DCE were consistent with the ‘gold standard’ CO
CMRI. This demonstrates that the low dose ultra-fast DCE-MRI can be used to accurately measure the AIF.}
}
@inproceedings{ISMRM2018_5017,
annote={ISMRM2018_5017},
pages={5017},
file={ISMRM2018_5017.pdf:ISMRM2018_5017.pdf:PDF},
title={Principal Process Analysis of dynamic Gluco{CEST} {MRI} data},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5017.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Stefano Casagranda and Marco Pizzolato and Francisco Torrealdea and Xavier Golay and Timothé Boutelier},
abstract={GlucoCEST is an MRI contrast enhancement technique sensitive to the concentration of sugar in the tissue. Because of a difference in metabolism, it is thought that tumors consume more sugar than normal tissue. However, glucose metabolism is complex and depends on many processes, which are all important to understand the origin of the measured signal. To achieve this goal we apply here a process analysis method to a deterministic system describing the metabolism of glucose in the tissue.}
}
@inproceedings{ISMRM2018_5018,
annote={ISMRM2018_5018},
pages={5018},
file={ISMRM2018_5018.pdf:ISMRM2018_5018.pdf:PDF},
title={{NOE} contributions to the z-spectrum of human blood},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5018.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Andrew John Carradus and Simon Shah and Olivier Mougin and Hans Hoogduin and Penny Gowland},
abstract={This study investigates the properties of relayed NOE effects in the blood by fitting z-spectra acquired using continuous wave saturation to the analytical solutions of the Bloch-McConnel equations. We systematically model for an increasing number of NOE peaks based on previous reports and find that adding in two NOE peaks at -3.5ppm and -1.7ppm significantly improves the fit, but adding further peaks does not. Furthermore, we fit for the exchange rates and T
2s of these pools and find that the peak at -3.5ppm has exchange rate=21.5Hz and T
2=0.9ms and the peak at -1.7 ppm has exchange rate=8.6Hz and T
2=3ms.}
}
@inproceedings{ISMRM2018_5019,
annote={ISMRM2018_5019},
pages={5019},
file={ISMRM2018_5019.pdf:ISMRM2018_5019.pdf:PDF},
title={Non-rigid atlas registration for improved quantitative assessment of rat brain regions with limited inherent anatomical contrast},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5019.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Matthew Tarasek and Jeannette Roberts and Deirdre Cassidy and Desmond Yeo and Randall Carter and Brian Bales},
abstract={We present a method for 3D non-rigid, feature-based atlas registration to images that contain limited inherent anatomical MR contrast. This method can be used to standardize ROI identification and may be applied to any multi-functional imaging technique to provide increased quantitative registration accuracy. Here quantitative T1 measurements were used to test the accuracy and reproducibility of the method. Overall, data analysis performed with atlas registration provides a 2-fold reduction in standard deviation and 4-fold increase in reproducibility versus data analysis performed without registration.}
}
@inproceedings{ISMRM2018_5020,
annote={ISMRM2018_5020},
pages={5020},
file={ISMRM2018_5020.pdf:ISMRM2018_5020.pdf:PDF},
title={Phenols as Diamagnetic T2-exchange Magnetic Resonance Imaging Contrast Agents},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5020.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jia Zhang and Yuguo Li and Stephania Slania and Nirbhay Yadav and Jing Liu and Rongfu Wang and Jianhua Zhang and Martin Pomper and Peter van Zijl and Xing Yang and Guanshu Liu},
abstract={To further explore the ability of usingdiamagnetic compounds for generating MRI contrast, we chose phenol as a model compound and systematically characterized its T
2-exchange (T
2ex) ability. We designed a library of phenol-based compounds and determined the effects of chemical modification on their proton exchange rate (k
ex) and chemical shift (∆ω) and consequently, their T
2ex contrast. A large ∆ω is favorable for generating strong T
2ex contrast, while there is an optimal k
exat each specific ∆ω. Finally, as an example of biomedical application, we demonstrated the label-free detection of tyrosinase activity using T
2ex MRI.}
}
@inproceedings{ISMRM2018_5021,
annote={ISMRM2018_5021},
pages={5021},
file={ISMRM2018_5021.pdf:ISMRM2018_5021.pdf:PDF},
title={Nanomicelles – A Blood Pool Contrast Agent for {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5021.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Vassily Vorobiev and Lindsey Alexandra Crowe and Yohan van de Looij and Lothar Helm and Samuel Espy and Andrej Babič and Jean-Paul Vallée and Eric Allémann},
abstract={A blood pool MRI contrast agent for free breathing MR angiography is highly desirable in particular for pediatric cardiovascular exams in order to improve both image quality and patient comfort. Apnea in infants and be propofol induced, or via intubation, which is invasive and limits acquisition to short protocols. We present here initial in-vivo studies in mice of a newly developed nanomicelles gadolinium contrast agent. Persistent vascular enhancement is observed with no toxicity. Micelles also open the way to functionalization for theranostic applications.}
}
@inproceedings{ISMRM2018_5022,
annote={ISMRM2018_5022},
pages={5022},
file={ISMRM2018_5022.pdf:ISMRM2018_5022.pdf:PDF},
title={Investigating the nature of distinct regions in brain tissue affected by stroke with principal component analysis of multi-b valued diffusion data},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5022.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ana-Maria Oros-Peusquens and Omid Nikoubashman and Martin Wiesmann and N. Jon Shah},
abstract={A data-driven, observer-independent segmentation of brain regions affected by stroke is proposed. It is based on PCA analysis of a multi b-value diffusion trace acquisition and offers fast, high-SNR visualisation of affected areas. Substructure of these areas is easily identified and can be automatically delineated using clustering algorithms.}
}
@inproceedings{ISMRM2018_5023,
annote={ISMRM2018_5023},
pages={5023},
file={ISMRM2018_5023.pdf:ISMRM2018_5023.pdf:PDF},
title={Reducing T2-related bias in mq-{BOLD} derived maps of Oxygen Extraction Fraction by 3D acquisition},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5023.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Stephan Kaczmarz and Jens Goettler and Andreas Hock and Dimitrios Karampinos and Claus Zimmer and Fahmeed Hyder and Christine Preibisch},
abstract={Multi-parametric quantitative BOLD (mq-BOLD) measurements have been successfully applied in several studies to assess the vascular oxygenation, however, calculated relative Oxygen Extraction Fraction (rOEF) shows unphysiological systematic elevations. We suspect biased T
2-measurements to be the main source of error. Therefore, we present an optimized 3D-GraSE T
2-mapping sequence and its evaluation in four stages within phantoms, young healthy controls, elderly controls and internal carotid artery stenosis (ICAS) patients. We found significant T
2-decreases, fully consistent with reference-values and thereby significantly decreased rOEF-values by ~25 \% towards physiologically more realistic values. Additional clinical value was demonstrated by detecting focal rOEF-increases in an ICAS-patient.}
}
@inproceedings{ISMRM2018_5024,
annote={ISMRM2018_5024},
pages={5024},
file={ISMRM2018_5024.pdf:ISMRM2018_5024.pdf:PDF},
title={Comparison of Labeling Capacity for Protamine-sulphate-conjugated and Fu{GENE}-labeled Progenitor Cardiac Stem Cells using Perfluorocarbon Nanoparticle Labels for In Vivo Murine Cardiac 19F {MRI}/{MRS}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5024.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Chris Constantinides and Akhilesh Rai and Mangala Srinivas and Lino Ferreira and Carolyn Carr},
abstract={Despite prior work, a direct comparison of the labeling of progenitor cardiac stem cells (CPCs) using protamine-sulphate (PS)-conjugated or FuGENE-labeled perfluorocarbon nanoparticle labels (based on their respective cellular uptake mechanisms) and their capacity to achieve direct cardiac 19FMRI on the same animal species, is still lacking. We report herein improved in vivo cardiac 19FMRI performance for FuGENE-labeled compared to PS-labeled CPCs.}
}
@inproceedings{ISMRM2018_5025,
annote={ISMRM2018_5025},
pages={5025},
file={ISMRM2018_5025.pdf:ISMRM2018_5025.pdf:PDF},
title={High rotating frame relaxation {MRI} mapping for detecting ischemia in rats},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5025.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Eleni Demetriou and Hanne Laakso and Timo Liimatainen and Silvia Mangia and Shalom Michaeli and Xavier Golay},
abstract={The goal of this work is to evaluate novel MRI technique entitled Relaxation Along a Fictitious Field (RAFF) in the rotating frame of rank n (RAFFn, with n=4) in its ability to detect ischemia, specifically when tuning the sensitivity of RAFF4 to exchange processes of amide protons. Relaxation maps were thus measured in healthy and infarcted rats at 24h post stroke and were compared with other conventionally used quantitative MRI modalities. RAFF4 robustly detected infarcted regions with enhanced contrast as compared to T1 relaxation and MTR asymmetry, thus offering a sensitive novel MRI marker for quantifying tissue abnormalities during ischemia.}
}
@inproceedings{ISMRM2018_5026,
annote={ISMRM2018_5026},
pages={5026},
file={ISMRM2018_5026.pdf:ISMRM2018_5026.pdf:PDF},
title={Direct D2O {MRI} for quantifying tissue permeability: application to Vitreous},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5026.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Shengwen Deng and Eric Muir and Shiliang Huang},
abstract={D2O is a freely diffusible trace for calculating blood flow and give more accurate than limited diffused Gadolinium based contrast agents. A few publications from over twenty years ago used MRI or single-voxel NMR spectroscopy to assess D2O (or 17O water) for tissue perfusion. However, these studies never investigated the application of D2O MRI to altered permeability. Our current study explore the dynamic direct D2O MRI to map tissue permeability and applied it to map the water exchange in rodent vitreous.}
}
@inproceedings{ISMRM2018_5027,
annote={ISMRM2018_5027},
pages={5027},
file={ISMRM2018_5027.pdf:ISMRM2018_5027.pdf:PDF},
title={Performance of ultrafast {DCE}-{MRI} for diagnosis of prostate cancer},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5027.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Aritrick Chatterjee and Dianning He and Xiaobing Fan and Shiyang Wang and Teodora Szasz and Ambereen Yousuf and Federico Pineda and Tatjana Antic and Melvy Mathew and Gregory S Karczmar and Aytekin Oto},
abstract={This study aimed to test high temporal resolution DCE- MRI for different zones of the prostate and evaluate its performance in the diagnosis of prostate cancer (PCa). High temporal resolution (~2.2s) was achieved by modestly decreasing spatial resolution, increasing sensitivity encoding and partial Fourier factors. Our results show that PCa had significantly faster signal enhancement and washout rates than normal tissue. DCE-MRI with higher temporal resolution may capture clinically useful information for PCa diagnosis that would be missed by low temporal resolution DCE-MRI. This new information could improve the performance of mpMRI in prostate cancer detection.}
}
@inproceedings{ISMRM2018_5028,
annote={ISMRM2018_5028},
pages={5028},
file={ISMRM2018_5028.pdf:ISMRM2018_5028.pdf:PDF},
title={Is the Parker arterial input function necessary to model the second pass for dynamic contrast enhanced {MRI}? - A simulation study},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5028.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Dianning He and Lisheng Xu and Wei Qian and Xiaobing Fan},
abstract={Accurately modeling arterial input function (AIF) is important for dynamic contrast enhanced (DCE) MRI. Simulations were performed comparing nine population AIF models to the Parker AIF. Effects of AIF second pass with and without adding noise onto extracted physiological parameters were evaluated with n=1,000 randomly generated physiological parameters (K
trans and v
e) used to calculate contrast agent concentration curves using the Tofts model and Parker AIF. Results demonstrated that the six-parameter linear function plus bi-exponential function AIF model was almost equivalent to Parker AIF. Effects of the second pass were small, unless noise with signal-to-noise ratio was <10 dB.}
}
@inproceedings{ISMRM2018_5029,
annote={ISMRM2018_5029},
pages={5029},
file={ISMRM2018_5029.pdf:ISMRM2018_5029.pdf:PDF},
title={Relaxivity of Ferumoxytol at 1.5T and 3.0T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5029.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Gesine Knobloch and Timothy Colgan and Curtis Wiens and Xiaoke Wang and Tilman Schubert and Diego Hernando and Scott Reeder},
abstract={Ferumoxytol (Feraheme, AMAG, Waltham, MA) is an iron supplement that has shown promise as an off-label alternative contrast agent for MRI. Optimization of imaging and dosing protocols requires accurate knowledge of the relaxation characteristics of ferumoxytol, which are currently not well understood. Therefore, the purpose of this work was to measure the r1, r2 and r2* relaxivity of ferumoxytol. Studies were performed at 1.5T and 3.0T over a range of concentrations, in saline, human plasma and human blood, all at body temperature.}
}
@inproceedings{ISMRM2018_5030,
annote={ISMRM2018_5030},
pages={5030},
file={ISMRM2018_5030.pdf:ISMRM2018_5030.pdf:PDF},
title={R2-Star \& {DCE}-Perfusion {MRI} based Novel Approach for Classification of Intra Tumoral Susceptibility Signal ({ITSS}) into Haemorrhage, Non-Leaky Vessels and Leaky Vessels in Glioblastoma},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5030.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Anup Singh and Rupsa Bhattacharjee and Prashant Budania and Pradeep Kumar Gupta and Rakesh Kumar Gupta and Sunita Ahlawat},
abstract={Susceptibility-weighted-imaging (SWI) demonstrates intra-tumoral-susceptibility-signal (ITSS) which could be a combination of haemorrhage and vasculature. True biological classification is necessary to understand the tumor-viability, aggressiveness and angiogenesis. This study develops a novel quantitative approach which combines SWI, R2-Star-relaxivity and DCE-MRI parameters for segmenting ITSS and its further classification into biological-behavior-based sub-categories. After analysis of 128 ITSS from 25 high-grade-glioblastoma patients, we found haemorrhages have higher R2-Star and lower rCBV values compared-to vessel ITSS. Leakage parameter Ve from tracer-kinetic analysis is found as differentiator between leaky and non-leaky-vessels. Proposed approach enables automatic-classification of ITSS into haemorrhage, non-leaky (passive) and leaky (aggressive) vessels.}
}
@inproceedings{ISMRM2018_5031,
annote={ISMRM2018_5031},
pages={5031},
file={ISMRM2018_5031.pdf:ISMRM2018_5031.pdf:PDF},
title={Formalin fixation significantly changes cell membrane permeability in cortical brain tissue},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5031.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ruiliang Bai and Xihui Ju and Peter J Basser},
abstract={Ex vivo, formalin-fixed biological tissue sample are often used to validate MRI methods for in vivo applications. However, since fixation may alter the chemical and physical properties of tissue, including the cell membrane permeability, it is important to know how and whether fixation changes in water microdynamics and potentially affects MRI signals. In this work, we studied the transmembrane water exchange kinetics in live rat brain cortical tissue in vitro and following formalin fixation. We found that the fixation process can significantly increase the transmembrane water exchange kinetics by increasing the cell membrane permeability to water.}
}
@inproceedings{ISMRM2018_5032,
annote={ISMRM2018_5032},
pages={5032},
file={ISMRM2018_5032.pdf:ISMRM2018_5032.pdf:PDF},
title={A compact solution for physiological parameters from ultrafast prostate {DCE}-{MRI} may reduce random and systematic errors},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5032.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Xiaobing Fan and Dianning He and Aritrick Chatterjee and Shiyang Wang and Milica Medved and Federico D Pineda and Ambereen Yousuf and Tatjana Antic and Aytekin Oto and Gregory S Karczmar},
abstract={The Tofts pharmacokinetic model requires multiple calculations for analysis of dynamic contrast enhanced (DCE) MRI. This can result in error propagation that reduces the accuracy of pharmacokinetic measurements. Here, we present a new compact solution for estimating physiological parameters based on changes in signal intensity, without the Tofts model. Human prostate DCE-MRI data were analyzed to compare physiological parameters estimated from proposed compact solution with the Tofts model. The K
trans and v
e from the compact solution correlated strongly with values from the Tofts Model. Bland–Altman plots showed moderate to excellent agreement between the compact solution and the Tofts Model.
}
}
@inproceedings{ISMRM2018_5033,
annote={ISMRM2018_5033},
pages={5033},
file={ISMRM2018_5033.pdf:ISMRM2018_5033.pdf:PDF},
title={Automated evaluation of T2 relaxation time measurements in the knee cartilage at 3T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5033.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ales Neubert and Craig Engstrom and Ilaria Croci and Shekhar S. Chandra and Benjamin Schmitt and Stuart Crozier and Jurgen Fripp},
abstract={A software framework for fully automated analysis in 3D of regional distribution of biochemical MRI values in knee cartilage sub-regions was proposed. The framework was compared to values extracted using manual segmentations and strong agreement with the automated measures was found. The framework was applied in a preliminary analysis to assess the reproducibility of T2 relaxation time measurements at 3T with promising results. The proposed automated framework can facilitate investigations and advance the search for biomarkers of pathophysiological processes preceding the development of osteoarthritis.}
}
@inproceedings{ISMRM2018_5034,
annote={ISMRM2018_5034},
pages={5034},
file={ISMRM2018_5034.pdf:ISMRM2018_5034.pdf:PDF},
title={Depth dependence of diffusion in articular cartilage of the knee visualized at 7T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5034.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Sander Brinkhof and Qinwei Zhang and Martijn Froeling and Gustav J. Strijkers and Aart J. Nederveen and Keita Ito and Dennis W.J. Klomp},
abstract={The goal of this study was to apply high-resolution diffusion weighted imaging (DWI) at 7T to assess depth dependence of diffusion in the articular cartilage in the knee. Four healthy volunteers were scanned with a diffusion prepared TSE sequence. ADC maps were consequently used to assess the depth dependence of ADC throughout the articular cartilage. The ADC value was shown to significantly increase from the bone-cartilage interface to the superficial zone. This work shows that the significant depth dependence of the ADC in cartilage layers can be observed in vivo on 7T with diffusion weighed imaging.}
}
@inproceedings{ISMRM2018_5035,
annote={ISMRM2018_5035},
pages={5035},
file={ISMRM2018_5035.pdf:ISMRM2018_5035.pdf:PDF},
title={Measurement of Acute Changes in Articular Cartilage T2 Relaxation Times Immediately After Exercise},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5035.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Joanna Langner and Feliks Kogan and Bryan Haddock and Garry Gold},
abstract={Increased joint loading is a known risk factor for progression of osteoarthritis (OA) of the knee. However, the acute effects of exercise and joint loading are still poorly understood. Quantitative MRI measures, such as T2 relaxation times, provide an opportunity to objectively study how exercise affects cartilage matrix organization and hydration. In this work, we evaluate the feasibility of measuring acute changes in T2 relaxation times immediately after exercise, in both knees simultaneously.}
}
@inproceedings{ISMRM2018_5036,
annote={ISMRM2018_5036},
pages={5036},
file={ISMRM2018_5036.pdf:ISMRM2018_5036.pdf:PDF},
title={T2-mapping of Femoral Cartilage 3-months Following {ACL} Reconstruction Surgery},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5036.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Marianne S. Black and Katherine A. Young and Akshay S. Chaudhari and Bragi Sveinsson and Feliks Kogan and Uchechukwuka Monu and Emily J. McWalter and Marc E. Levenston and Garry E. Gold and Brian A. Hargreaves},
abstract={T2-mapping can be used to detect changes in cartilage following ACL injury that are indicative of cartilage degeneration. We imaged subjects at 3-weeks and 3-months post-ACL-reconstruction surgery to obtain T2 relaxation times for the femoral cartilage of both knees. A trend in increasing T2 relaxation times was observed for the injured knee at 3-months relative to 3-weeks, although this increase was not significant, while T2 remained consistent for the contralateral knee in this time. This work demonstrates that changes to cartilage may be occurring earlier than expected in the injured knee following ACL-reconstruction surgery.}
}
@inproceedings{ISMRM2018_5037,
annote={ISMRM2018_5037},
pages={5037},
file={ISMRM2018_5037.pdf:ISMRM2018_5037.pdf:PDF},
title={T2 texture features can detect differences between the discs of patient with and without low back pain},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5037.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Vahid Abdollah and Eric C Parent and Maria Beketskaia and Jeff F. Dunn},
abstract={Conventional MRI is often clinically inconclusive in diagnosing the pathology of back pain, as both symptomatic and asymptomatic individuals demonstrate the same abnormal features. We hypothesized that texture driven features could be deployed to identify the underlying pathology of low back pain. Fourteen patients with chronic back pain were matched (age, weight and gender) with 14 healthy volunteers. A grey-level co-occurrence matrix with one- to four-pixel offset and four directions was constructed to extract texture features. The texture analysis results indicated the discs of the healthy subjects were more uniform (lower contrast) than those of the participants with back pain.}
}
@inproceedings{ISMRM2018_5038,
annote={ISMRM2018_5038},
pages={5038},
file={ISMRM2018_5038.pdf:ISMRM2018_5038.pdf:PDF},
title={Compositional assessment of low-grade cartilage lesions using T2 mapping at 3 and 7 Tesla {MRI}: a one year follow-up study},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5038.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Vladimir Juras and Markus Schreiner and Didier Laurent and Stefan Zbyn and Vladimir Mlynarik and Pavol Szomolanyi and Celeste Scotti and Joerg Goldhahn and Harry Haber and Ewa Kubiak and Stefan Marlovits and Rahel Heule and Oliver Bieri and Ivan Frollo and Siegfried Trattnig},
abstract={T2 maps were assessed as a potential marker for the long-term follow-up of the patients with cartilage lesions ICRS Grade I-II in five time points (baseline, 8 days, 3, 6 and 12 months). For the T2 mapping, a 3D triple echo steady state sequence which is capable of delivering high quality high-resolved T2 maps at ultra-high field MRI was used. We observed a significant decrease in T2 values at 3T over time in superficial zone of the cartilage defect. There was no statistically significant change at 7T. T2 mapping could be used in the future as a good alternative to cartilage biopsies in clinical trials on new therapies aimed at cartilage regeneration.}
}
@inproceedings{ISMRM2018_5039,
annote={ISMRM2018_5039},
pages={5039},
file={ISMRM2018_5039.pdf:ISMRM2018_5039.pdf:PDF},
title={A composite metric R2-R1ρ measures an incomplete anisotropic R2 of human femoral cartilage at 3T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5039.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yuxi Pang and Riann M Palmieri-Smith and Thomas L Chenevert},
abstract={The composite relaxation metric R
2-R
1ρ, a potential MR imaging biomarker for detecting early cartilage degeneration, was shown as an incomplete orientation-dependent R
2 at 3T. Both R
2 and R
1ρ mappings of femoral cartilage were performed on two subjects and the constructed composite metrics were compared to the anisotropic R
2 values that were extracted from a single 3D T2W dataset using a newly developed method. The preliminary results demonstrated that the orientation-dependent information derived from two completely different methods was comparable, implying that the diagnostically most relevant information in knee or other joint cartilage could be easily and efficiently obtained.}
}
@inproceedings{ISMRM2018_5040,
annote={ISMRM2018_5040},
pages={5040},
file={ISMRM2018_5040.pdf:ISMRM2018_5040.pdf:PDF},
title={{DESS} vs T1-{FLASH} 3D-{MRI} for Knee Cartilage Segmentation: An Evaluation Using Deep 3D-{CNN}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5040.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Archit Raj and Harsh Kumar Agarwal},
abstract={Automated knee cartilage segmentation can potentially improve the clinical utility of the MRI assessment of knee osteoarthritis due to the convoluted structure of the knee cartilage in 3D. Recently deep convolutional neural network (CNN) have shown better performance for knee cartilage segmentation. Unlike other segmentation algorithms deep-CNN techniques learn the model parameters from the data itself. Therefore, this abstract proposed that deep 3D-CNN techniques can be used to determine the optimal MRI sequence for knee cartilage segmentation and demonstrated that 3D-DESS MRI have statistically better segmentation performance as compared to 3D-T
1-FLASH MRI.}
}
@inproceedings{ISMRM2018_5041,
annote={ISMRM2018_5041},
pages={5041},
file={ISMRM2018_5041.pdf:ISMRM2018_5041.pdf:PDF},
title={Prediction of the mechanical properties of articular cartilage with {QSM} and T2* in equine post traumatic osteoarthritis model},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5041.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Olli Juhani Nykänen and Juuso Ketola and Henri Leskinen and Jaakko Sarin and Nikae te Moller and Irina A.D. Mancini and Harold Brommer and Rene van Weeren and Jos Malda and Juha Töyräs and Mikko J Nissi},
abstract={In this study, we investigated the potential of quantitative susceptibility mapping (QSM) and T2* mapping to predict the mechanical properties of equine articular cartilage. To assess the potential of these parameters, they were used to predict the biomechanical properties of cartilage using artificial neural network (ANN) modelling of the 235 mechanical testing points in 20 equine samples representing variable tissue properties. The results indicated that both T2* and QSM correlate moderately with biomechanics (r=0.648 and r=0.652, respectively) and combining these parameters improved the correlation slightly (r=0.714). The study highlights the potential of both quantitative MRI and ANN-analysis in cartilage imaging.}
}
@inproceedings{ISMRM2018_5042,
annote={ISMRM2018_5042},
pages={5042},
file={ISMRM2018_5042.pdf:ISMRM2018_5042.pdf:PDF},
title={Simplified method for estimating chemical exchange rate in human knee cartilage from R1rho dispersion},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5042.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ping Wang and John C. Gore},
abstract={Chemical exchange between water and exchangeable protons in macromolecules in knee cartilage can be quantified by fitting R
1ρ dispersion data to a model. However, acquiring the entire dispersion curve is time consuming, which therefore hampers the application in clinical practice. We propose a simple three-point method for R
1ρ dispersion data to estimate exchange rate. The method requires data acquired at three selected spin-locking frequencies instead of acquiring a full dispersion curve. The results show good agreement between the proposed method and measurements from the full dispersion data.}
}
@inproceedings{ISMRM2018_5043,
annote={ISMRM2018_5043},
pages={5043},
file={ISMRM2018_5043.pdf:ISMRM2018_5043.pdf:PDF},
title={3D Ultrashort Echo Time {MRI} for Evaluation of Cartilaginous Endplate of Lumbar Disc In Vivo: Feasibility and Correlation with Disc Degeneration in T2 weighted Spin Echo Sequence},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5043.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yeoju Kim and Jang Gyu Cha and Gwang Pyo Hong and Juhyuen Ryu},
abstract={Total 165 discs of 33 patients were imaged with sagittal 3D UTE (TR = 16.1 ms, TE = 0.032 ms and 6.6 ms, echo-subtraction) with 3D cones trajectory technique and conventional sagittal T2 weighted (TR = 3232, TE = 91.4) SE in 3T MRI. Two musculoskeletal radiologists evaluated the CEP abnormalities such as irregularity, thickening, thining and defects in the 3D UTE with consensus and correlated with the Pfirrmann grading system in the sagittal T2 SE. In result, all of the CEP abnormalities were positively correlated with the Pfirrmann grading system with statistical significance (p < 0.001).}
}
@inproceedings{ISMRM2018_5044,
annote={ISMRM2018_5044},
pages={5044},
file={ISMRM2018_5044.pdf:ISMRM2018_5044.pdf:PDF},
title={{MR} Evaluation of Disco-Vertebral Junction: Effects of Sequence and Parameters on {SNR} and {CNR}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5044.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Palanan Siriwananrangsun and Tim Finkenstädt and Tailynn S Chen and Michael Carl and Reni Biswas and Colin Bae and Sheronda Statum and Graeme M Bydder and Christine B Chung and Won C Bae},
abstract={The disco-vertebral junction of lumbar spine contains thin structures with short T2 values, including cartilaginous endplate (CEP) sandwiched between the bony vertebral endplate (VEP) and nucleus pulposus (NP). We have demonstrated that ultrashort echo time MRI is able to capture signal from cartilaginous endplate and we sought to further refine the technique by characterizing contrast-to-noise ratio of these tissues when varying echo times are used. Optimal contrast between CEP and VEP was achieved with UTE source image at the shortest TE, while a balanced contrast between all tissues was achieved by Cones Subtraction imaging at a long 2nd TE.}
}
@inproceedings{ISMRM2018_5045,
annote={ISMRM2018_5045},
pages={5045},
file={ISMRM2018_5045.pdf:ISMRM2018_5045.pdf:PDF},
title={A comparative study of diffusion kurtosis imaging and T2* mapping in quantitative evalutation of lumbar intervertebral disc degeneration},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5045.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Feifei Zeng and Yunfei Zha and Yang Fan},
abstract={The purpose of this study is to compare the diagnostic value of diffusion kurtosis imaging (DKI) and T2* mapping in assessing lumbar intervertebral disc degeneration. DKI related parameters, such as mean kurtosis (MK), mean diffusivity (MD), fractional anisotropy (FA), FA of Kurtosis (FAK) and T2* values of nucleus pulposus (NP), anterior annulus fibrosus (AAF) and posterior annulus fibrosus (PAF) were measured and correlated with Pfirrmann grades, disc level, gender and age. It was found that DKI related parameters and T2* values had significantly correlation with Pfirrmann grades, disc leveland, age, but had no significantly correlation with gender. In addition, DKI was more sensitive than T2* mapping in quantitative detection of early lumbar intervertebral disc degeneration.}
}
@inproceedings{ISMRM2018_5046,
annote={ISMRM2018_5046},
pages={5046},
file={ISMRM2018_5046.pdf:ISMRM2018_5046.pdf:PDF},
title={Comparison of {DENSE}-{FISP} and {DENSE}-{FID} for assessment of cartilage strain computation under compressive loading.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5046.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Willy Zavenbergen and Willy Gsell and Maria-Ioana Pastrama and Deva Chan and Corey Neu and Uwe Himmelreich and Ilse Jonkers},
abstract={While true-FISP provides increased signal to noise ratio, it is also prone to banding artefacts due to incoherent dephasing. We thus here compare true-FISP DENSE with FID-DENSE to estimate cartilage strain under compressive loading. As FID-DENSE will be artefact free however at the expense of a lower signal to noise ratio, we investigate if DENSE-FID or DENSE-FISP will provide a more robust computation of cartilage strains under compressive loading.}
}
@inproceedings{ISMRM2018_5047,
annote={ISMRM2018_5047},
pages={5047},
file={ISMRM2018_5047.pdf:ISMRM2018_5047.pdf:PDF},
title={T1ρ dispersion assessment of articular cartilage in a rabbit {ACL} transection model},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5047.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Abdul Wahed Kajabi and Victor Casula and Simo Ojanen and Mikko Finnilä and Rami K. Korhonen and Walter Herzog and Simo Saarakkala and Mikko J. Nissi and Miika T. Nieminen},
abstract={T1ρ dispersion measurements were performed to assess early degenerative changes in articular cartilage in an experimentally induced anterior cruciate ligament transection (ACLT) rabbit model. T2 and T1ρ with spin-lock field amplitudes of 500 Hz, 1 kHz and 2 kHz were measured at 9.4 T. Cartilage mechanical properties and proteoglycan content were determined using indentation testing and quantitative histology, respectively. T1ρ dispersion identified degenerative alterations in cartilage as early as two weeks after ACL transection. The dispersion parameters were statistically correlated with biomechanical properties and proteoglycan content.}
}
@inproceedings{ISMRM2018_5048,
annote={ISMRM2018_5048},
pages={5048},
file={ISMRM2018_5048.pdf:ISMRM2018_5048.pdf:PDF},
title={T2 Relaxometry of Cartilage and Meniscus and Semi-Quantitative Assessment of the Osteoarthritic Knee using a fast 3D Quantitative {DESS} Scan},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5048.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Susanne Eijgenraam and Akshay Chaudhari and Max Reijman and Edwin Oei and Brian Hargreaves and Garry Gold},
abstract={In this study, we investigated quantitative and semi-quantitative MR imaging biomarkers of knee OA, obtained with a
5-minute DESS sequence, in increasing stages of
knee OA. 54 patients were included: 20 patients with no knee OA, 18 patients with mild knee OA and 16 patients with moderate knee OA. All patients were scanned using DESS and a routine clinical knee MRI protocol. Simultaneous quantitative T2 and morphological assessment of cartilage and meniscus with a 5-minute DESS-sequence showed consistent outcomes with increasing stages of degeneration, making this sequence a useful tool for OA research.}
}
@inproceedings{ISMRM2018_5049,
annote={ISMRM2018_5049},
pages={5049},
file={ISMRM2018_5049.pdf:ISMRM2018_5049.pdf:PDF},
title={Optimizing $T_{1\rho}$ dispersion measurements for correlation time mapping in articular cartilage at 9.4 T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5049.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Hassaan Elsayed and Stefan Zbyn and Nina Hänninen and Timo Liimatainen and Mikko J. Nissi and Miika T. Nieminen and Matti Hanni},
abstract={Correlation time ($\tau_c$) is an intrinsic property of molecules that can be probed from $T_{1\rho}$ dispersion measurement. The aim of this study was to evaluate the effect of low and high spin-lock frequencies (SLFs) on $\tau_c$ fitting and to find the optimum SLFs set within the typical clinical range. One bovine and two human cartilage samples were scanned to obtain $T_{1\rho}$ dispersion with 22 SLFs between 10 to 2500 Hz. $\tau_c$ maps were obtained by fitting Lorentzian function to different subsets of $T_{1\rho}$ dispersion. Our results show that $\tau_c$ fitting is significantly affected by low SLFs compared to high SLFs.}
}
@inproceedings{ISMRM2018_5050,
annote={ISMRM2018_5050},
pages={5050},
file={ISMRM2018_5050.pdf:ISMRM2018_5050.pdf:PDF},
title={T2 mapping pseudo-color pictures and {FS}-{FSE}- {PDWI} in grading diagnosis of patellar cartilage damage:a retrospective study compared with arthroscopy},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5050.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Shaowei Zheng and Jing Chen and Weisheng Zhang and Qingwei Song},
abstract={Our institution use arthroscopy as the gold standard, apply T2mapping and FS-FSE- PDWI for the evaluation of patellar cartilage damage, to investigate value of T2 mapping pseudo-color pictures in assessment of patellar cartilage injury grading. This group of 45 cases of patellar cartilage damage, the correlations of T2mapping pseudo color grading,FS-FSE- PDWI grading and arthroscopic grading were analyzed, found the correlation between T2mapping pseudo color and arthroscopy precedes that between FS-FSE- PDWI and arthroscopy. Therefore, we believe that the T2mapping pseudo color can be used to evaluate the patellar cartilage damage and better than FS-FSE- PDWI.}
}
@inproceedings{ISMRM2018_5051,
annote={ISMRM2018_5051},
pages={5051},
file={ISMRM2018_5051.pdf:ISMRM2018_5051.pdf:PDF},
title={Orientation anisotropy of q{MRI} parameters in degenerated human articular cartilage},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5051.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Nina Hänninen and Olli Nykänen and Mithilesh Prakash and Matti Hanni and Miika Tapio Nieminen and Mikko Johannes Nissi},
abstract={Quantitative MR relaxation parameters have been used for evaluation of composition and structure of articular cartilage and demonstrated to have variable sensitivity to orientation of the tissue in magnetic field. The orientation dependence of multiple relaxation parameters was assessed in human cartilage of varying degree of degeneration and correlated with biomechanical testing. T
2 and CW-T
1ρ at 400Hz spin-lock demonstrated most clear anisotropy patterns which varied among the samples of different cartilage quality.}
}
@inproceedings{ISMRM2018_5052,
annote={ISMRM2018_5052},
pages={5052},
file={ISMRM2018_5052.pdf:ISMRM2018_5052.pdf:PDF},
title={Ultra-high-field (7 Tesla) {MRI} study of the articular cartilage in normal subjects},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5052.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Giacomo Aringhieri and Massimo Marletta and Sara Toscano and Laura Biagi and Gianluigi Tiberi and Michela Tosetti and Mirco Cosottini and Virna Zampa},
abstract={Ultra High Field MRI gives the opportunity to study in vivo articular cartilage with optimal signal-to-noise ratio, contrast-to-noise ratio and spatial resolution in comparison with lower field strength systems. We obtained the mean T2 and T2* maps values for under and over 50 years aged healthy subjects, both mean values increase with the subjects' age. With dedicated multichannel coils and specific cartilage sequences, it is possible to make both a qualitative and a quantitative evaluation of early and pre-clinical cartilage ageing-related changes in estimating the water content and the integrity of the cartilage matrix.}
}
@inproceedings{ISMRM2018_5053,
annote={ISMRM2018_5053},
pages={5053},
file={ISMRM2018_5053.pdf:ISMRM2018_5053.pdf:PDF},
title={Accelerated T1ρ Dispersion Data Acquisition for Correlation Time Mapping of Cartilage at 3T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5053.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Stefan Zbyn and Mikko J. Nissi and Hassaan Elsayed and Victor Casula and Matti Hanni and Timo Liimatainen and Miika T. Nieminen},
abstract={Correlation time (τ
c) is novel MRI parameter that can be calculated from time demanding dispersion measurements of longitudinal relaxation times in the rotating frame (T
1ρ). Therefore methods able to accelerate data acquisition are needed for τ
c mapping of cartilage in vivo. Present results demonstrate that partial k-space acquisition and Parallel Imaging can reduce imaging time while having small influence on τ
c values. Although long TurboGRE readout train significantly decreases τ
c values, it allows the τ
c mapping of cartilage in clinically acceptable measurement times. The τ
c mapping may therefore serve for the noninvasive in vivo evaluation of cartilage at 3T.}
}
@inproceedings{ISMRM2018_5054,
annote={ISMRM2018_5054},
pages={5054},
file={ISMRM2018_5054.pdf:ISMRM2018_5054.pdf:PDF},
title={Sodium Imaging of Untreated Cartilage Lesions in the Knee Joint: 3-months and 6-months Follow-up Study at 7T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5054.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Stefan Zbyn and Markus Schreiner and Vladimir Mlynarik and Vladimir Juras and Pavol Szomolanyi and Didier Laurent and Celeste Scotti and Harry Haber and Joerg Goldhahn and Ewa Kubiak and Xeni Deligianni and Oliver Bieri and Stefan Marlovits and Miika T. Nieminen and Siegfried Trattnig},
abstract={Sodium MRI was used for the follow-up of patients with cartilage lesions at 7T. MRI was obtained at baseline, 8-days, 3-months and 6-months follow-up. Regions-of-interest evaluations were performed in weight-bearing, non-weight-bearing and lesion area of femoral cartilage. Sodium values were significantly lower in lesion than in weight-bearing and non-weight-bearing regions at all follow-up measurements. On the other hand, weight-bearing and non-weight-bearing cartilage regions showed stable sodium values over the follow-up time. Sodium imaging allows noninvasivein vivo monitoring of changes in cartilage GAG content and thus can be useful for the evaluation of cartilage degeneration or cartilage regenerating therapies.}
}
@inproceedings{ISMRM2018_5055,
annote={ISMRM2018_5055},
pages={5055},
file={ISMRM2018_5055.pdf:ISMRM2018_5055.pdf:PDF},
title={Texture features from T2 mapping of talar dome cartilage in normal volunteers and dancers},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5055.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Hon J. Yu and Saya Horiuchi and Alex Luk and Adam Rudd and Jimmy Ton and Edward Kuoy and Jeff Russell and Kelli Sharp and Hiroshi Yoshioka},
abstract={This study demonstrates a feasibility of texture analysis based on T2 mapping of the talar-dome cartilage. Some of the investigated texture features showed statistically significant differences between healthy volunteers and ballet dancers that are regional in nature and also very much dependent on how the spatial distribution of T2 pixels is defined during calculation of texture features. More conventional analytic approach, such as comparison based on cartilage-averaged T2 value, failed to show any difference between the groups. The results in this study demonstrate an alternative analytical approach based on texture features as surrogate variables for the evaluation of cartilage properties.}
}
@inproceedings{ISMRM2018_5056,
annote={ISMRM2018_5056},
pages={5056},
file={ISMRM2018_5056.pdf:ISMRM2018_5056.pdf:PDF},
title={Improved 3D T1rho and T2 Mapping with Synovial Fluid Suppression for the Knee Cartilage on 3T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5056.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Qi Peng and Can Wu and Xiaojuan Li and Karen Sperling},
abstract={T1rho and T2 values of synovial fluid are more than twenty times larger than those of the normal cartilage tissue at 3T. The potential signal contamination originated from synovial fluid within the joints adjacent to the concerned articular cartilage could be a major source of errors associated with current T1rho and T2 mapping sequences in clinical research. In this study, we presented a long-T2-selective suppression module to null synovial fluid signal while preserve cartilage signal for acquisition. Its performance in 3D continuous-wave T1rho, adiabatic T1rho and T2 mapping sequences was evaluated in phantom and human studies.
}
}
@inproceedings{ISMRM2018_5057,
annote={ISMRM2018_5057},
pages={5057},
file={ISMRM2018_5057.pdf:ISMRM2018_5057.pdf:PDF},
title={Evaluation of Resting-State {BOLD} {MRI} of Calf Muscles in Healthy Volunteers and Patients with Peripheral Arterial Disease},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5057.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Shiteng Suo and Qing Lu and Lan Zhang and Hui Tang and Qihong Ni and Suqin Li and Haimin Mao and Xiangyu Liu and Jianxun Qu and Jianrong Xu},
abstract={BOLD MRI is a helpful imaging modality for assessing tissue oxygenation/perfusion characteristics in skeletal muscles. However, few studies have explored the utility of resting-state BOLD MRI in healthy subjects and patients with peripheral arterial disease (PAD). We conducted this study aimed at addressing this question and results showed that (1) T2* was found to be independent of age factor in calf muscles; (2) T2* was useful for differentiating PAD patients with age-matched older healthy subjects, as well as mild-to-moderate PAD patients with severe ones; and (3) T2* correlated well with ankle-brachial index in PAD patients.}
}
@inproceedings{ISMRM2018_5058,
annote={ISMRM2018_5058},
pages={5058},
file={ISMRM2018_5058.pdf:ISMRM2018_5058.pdf:PDF},
title={Comparison thigh skeletal muscles between snowboarding halfpipe athletes and healthy volunteers by using quantitative multi-parameter {MR} imaging at rest},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5058.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Shinong Pan and He Sun and Mengtao Xu and Xiaoqi Wang and Menghu Wang and Baoheng Wang and Fengzhe Wang},
abstract={To quantitatively investigate thigh skeletal muscles difference between snowboarding halfpipe athletes and healthy volunteers via MRI.}
}
@inproceedings{ISMRM2018_5059,
annote={ISMRM2018_5059},
pages={5059},
file={ISMRM2018_5059.pdf:ISMRM2018_5059.pdf:PDF},
title={Decreasing Water T2 based on multi-{TE} single-voxel {MRS} in fatty infiltrated skeletal muscles of patients with neuromuscular diseases},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5059.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Sarah Schlaeger and Dominik Weidlich and Elisabeth Klupp and Federica Montagnese and Marcus Deschauer and Benedikt Schoser and Sarah Bublitz and Claus Zimmer and Ernst J. Rummeny and Jan S. Kirschke and Dimitrios C. Karampinos},
abstract={Quantitative imaging techniques are emerging in the field of magnetic resonance imaging of neuromuscular diseases. Water T2 and proton density fat fraction are the most important imaging markers to assess edematous and fatty transformation in the patients’ muscle tissue. To validate the accuracy of quantitative methods
1H magnetic resonance spectroscopy can be used as a reference standard. The present study investigates water T2 of remaining muscle tissue in regions of higher proton density fat fraction in 42 patients with various neuromuscular diseases using multi-TE single-voxel MRS.}
}
@inproceedings{ISMRM2018_5060,
annote={ISMRM2018_5060},
pages={5060},
file={ISMRM2018_5060.pdf:ISMRM2018_5060.pdf:PDF},
title={Effectiveness of Diffusion-Tensor Imaging adapted to chemical-shift-encoded water-fat {MRI} in dystrophic skeletal muscle},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5060.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Sarah Keller and Zhiyue J. Wang and Annette Aigner and Amir Golsari and Hendrik Kooijman and Gerhard Adam and Jin Yamamura},
abstract={Diffusion tensor imaging of the skeletal muscle has been successfully applied in various conditions such as inflammation, age and trauma. However it remains challenging in dystrophic skeletal muscle as reliable acquisition of tensor metrics is hampered due to fatty infiltration. This study aimed to assess the effectiveness of a simple clinical approach on region-of-interest localization choosing either a custom, whole muscle ROI or a selective ROI excluding areas of fatty replacement. The effect of ROI localization on tensor metrics was calculated based on mixed effect models.}
}
@inproceedings{ISMRM2018_5061,
annote={ISMRM2018_5061},
pages={5061},
file={ISMRM2018_5061.pdf:ISMRM2018_5061.pdf:PDF},
title={Do {MR} biomarkers for muscular fat infiltration and atrophy correlate with functionality and the {DMPK} {CTG} repeat length in myotonic dystrophy type 1?},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5061.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Linda Heskamp and Marlies van Nimwegen and Guillaume Bassez and Cecilia Jimenez-Moreno and Marieke Ploegmakers and Jean-Francois Deux and Grainne Gorman and Darren Monckton and Baziel van Engelen and Arend Heerschap},
abstract={Quantitative MRI provides objective non-invasive biomarkers for muscle pathology in muscular dystrophy disorders. In this work we show that MR biomarkers for muscular fat infiltration and atrophy accurately reflect clinical outcomes for disease severity and physical capacity in myotonic dystrophy type 1 (DM1) patients. Furthermore, we found that 37\% of the variation in fat infiltration in DM1 patients was explained by age. Interestingly, an additional 9.7\% of the variation in fat infiltration was associated with the over life time increase in the DMPK CTG repeat length, i.e. the genetic defect causing DM1.}
}
@inproceedings{ISMRM2018_5062,
annote={ISMRM2018_5062},
pages={5062},
file={ISMRM2018_5062.pdf:ISMRM2018_5062.pdf:PDF},
title={Reproducibility of Diffusion Tensor Imaging ({DTI}) in the hamstrings of healthy athletes},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5062.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jithsa R. Monte and Melissa T. Hooijmans and Martijn Froeling and Jos Oudeman and Johannes L. Tol and Mario Maas and Gustav J. Strijkers and Aart J. Nederveen},
abstract={Muscle injuries are diagnosed using T2-weighted scans, but these techniques lack specificity for assessing tissue repair. DTI seems more suitable for this purpose, but reproducibility data is lacking. Therefore, the aim of this study was to determine the reproducibility of DTI, expressed as the within subject CV per DTI parameter in the hamstrings of healthy athletes. The wsCV values reported here for DTI parameters are superior or similar to previously reported wsCV. In conclusion, our protocol allows us to perform DTI on both upper legs simultaneously with an overall high SNR and high reproducibility.}
}
@inproceedings{ISMRM2018_5063,
annote={ISMRM2018_5063},
pages={5063},
file={ISMRM2018_5063.pdf:ISMRM2018_5063.pdf:PDF},
title={Combined accelerated 4D Phase Contrast and 3D Diffusion Tensor Imaging reveals a complex relation between strain and muscle architecture in contracting leg muscles},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5063.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Valentina Mazzoli and Martijn Froeling and Lukas M Gottwald and Nico Verdonschot and Melissa T Hooijmans and Aart J Nederveen and Gustav J Strijkers},
abstract={Skeletal muscles are geometrically complex 3D structures and cannot be fully characterized by 2D imaging. Therefore, a complete understanding of mechanisms of force transmission and strain development in relation to muscle architecture during contraction requires a 3D approach. We measured strain rate in the lower leg using a 4D accelerated Phase Contrast protocol and 3D muscle architecture with DTI. Our 3D strain rate data revealed a planar pattern, with one negative and one positive strain rate eigenvalue. Strain rate data combined with 3D muscle architecture, suggested a complex and heterogeneous behavior of strain development during muscle contraction.}
}
@inproceedings{ISMRM2018_5064,
annote={ISMRM2018_5064},
pages={5064},
file={ISMRM2018_5064.pdf:ISMRM2018_5064.pdf:PDF},
title={Modeling skeletal muscle perfusion through application of the continuous time random walk model to diffusion-weighted images},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5064.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={David Reiter and Fatemeh Adelnia and Donnie Cameron and Christopher Bergeron and Richard G. Spencer and Luigi Ferrucci},
abstract={The continuous time random walk (CTRW) model provides a flexible framework for representing complex diffusive processes, allowing for smooth interpolation between sub- and super-diffusion. This work presents supporting arguments for the application of the CTRW model to the measurement of skeletal muscle perfusion. We present model fit parameters from DW images of human skeletal muscle and compare estimates of intravascular volume fraction with previously reported values obtained using intravital microscopy.}
}
@inproceedings{ISMRM2018_5065,
annote={ISMRM2018_5065},
pages={5065},
file={ISMRM2018_5065.pdf:ISMRM2018_5065.pdf:PDF},
title={Effectiveness of fatty fraction by high-speed T2-corrected multi-echo {SVS} ({HISTO}) and multi-echo 3D {DIXON} (m{DIXON}) in rapid and robust acquisition for Duchenne Muscular Dystrophy},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5065.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Xiaolei Zhu and Guijin Li and Zhiyong Li},
abstract={The purpose of this study is to assess a potential fat quantitative technique in Duchenne muscular dystrophy (DMD), one of High-Speed T2-corrected multi echo(HISTO) acquisition with multi echoMRS, which is a rapid way in quantifying fatty content of pelvic and thigh muscles with confound effect and then a rapid multi echo3D Dixon technique was performed with multi peakfitted and R2* correction method to further evaluated the un-confounded fat fraction and the region of fat content in muscles. Proposed protocol was used to quantify the accuracy of fatfraction in DMD patients; both of measurements demonstrate strong consistency in fat quantification.}
}
@inproceedings{ISMRM2018_5066,
annote={ISMRM2018_5066},
pages={5066},
file={ISMRM2018_5066.pdf:ISMRM2018_5066.pdf:PDF},
title={Quantitative water T2 mapping and 31P {NMR} spectroscopy to evaluate disease progression and activity in {GNE} myopathy patients},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5066.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Harmen Reyngoudt and Julien Le Louër and Ericky CA Araujo and Benjamin Marty and Pierre-Yves Baudin and Jean-Yves Hogrel and Teresa Gidaro and Laurent Servais and Pierre G Carlier},
abstract={GNE myopathy (GNEM) is a neuromuscular disorder, characterized by distal lower limb muscle atrophy known for the relative preservation of quadriceps muscles. Quantitative NMRI including fat fraction and water T
2 mapping as well as
31P NMRS were performed in 10 GNEM patients and controls. In contrast to functional and strength tests, qNMRI and
31P NMRS could detect significant changes in FF and
31P NMRS indices such as pH over the course of 1 year. More interestingly, we could also demonstrate highly significant correlations between water T
2 and the rate of transformation of muscle tissue into fat, demonstrating the strength of water T
2 as an indicator of disease activity.}
}
@inproceedings{ISMRM2018_5067,
annote={ISMRM2018_5067},
pages={5067},
file={ISMRM2018_5067.pdf:ISMRM2018_5067.pdf:PDF},
title={Skeletal muscle tissue characterization of Duchenne muscular dystrophy patients by 1H- and 23Na-{MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5067.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Teresa Gerhalter and Lena V. Gast and Benjamin Marty and Regina Trollmann and Sophia Rügner and Stephanie Schüssler and Frank Roemer and Frederik B. Laun and Michael Uder and Pierre G. Carlier and Armin M. Nagel},
abstract={Duchenne muscular dystrophy (DMD) is a hereditary neuromuscular disease leading to progressive muscle wasting. As there is a need to identify NMR variables as potential early sensitive indicators of dystrophic muscle response to treatment, we evaluated the sensitivity of
23Na NMR in DMD in comparison to the commonly used water T2 and fat fraction. Sodium anomalies seemed to be systematically present and precede water T2 increases and fatty degenerative changes, also in muscles that were relatively spared. Although still limited in the small number of subjects, the data supports that
23Na could be used to characterize early dystrophic muscle alteration.}
}
@inproceedings{ISMRM2018_5068,
annote={ISMRM2018_5068},
pages={5068},
file={ISMRM2018_5068.pdf:ISMRM2018_5068.pdf:PDF},
title={Assessment for Lumbar Paraspinal Muscle Activation Before and After Exercises Using {BOLD} and T2-Mapping Imaging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5068.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Bo He and Yilong Huang and Jialong Zhou and Wei Zhao and Dan Han and Weibo Chen},
abstract={BOLD and T2-mapping might serve as noninvasive methods to evaluate the muscle activation of paraspinal muscles, thus providing deeper insights into muscle physiology. This has made possible the evaluation of the efficacy of early clinical exercise therapy for patients with lower-back pain.}
}
@inproceedings{ISMRM2018_5069,
annote={ISMRM2018_5069},
pages={5069},
file={ISMRM2018_5069.pdf:ISMRM2018_5069.pdf:PDF},
title={Rapid Measurement of {ATP} Kinetics in Human Skeletal Muscle at 7T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5069.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jimin Ren and A. Dean Sherry and Craig R. Malloy},
abstract={Measuring ATP energy metabolism in human subjects by conventional 31P saturation transfer (ST) is challenging because of multiple competing metabolic pathways, high SAR and artifacts caused by the prolonged B1-saturation pulses. EKIT (exchange kinetics by inversion transfer) allows magnetization transfer (MT) to evolve in the absence of B1 pulsing and multiple pathways can be probed by inverting all spins individually, but the process is time consuming and MT effects are small. A multi-module EBIT technique (exchange kinetics by band inversion transfer) addresses these issues and provides a comprehensive picture of ATP kinetics in human skeletal muscle.}
}
@inproceedings{ISMRM2018_5070,
annote={ISMRM2018_5070},
pages={5070},
file={ISMRM2018_5070.pdf:ISMRM2018_5070.pdf:PDF},
title={Semi-automatic segmentation of individual muscles in {MR} images: A new tool dedicated to the follow-up of patients with neuromuscular disorders},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5070.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Augustin C Ogier and Linda Heskamp and Alexandre Fouré and Marc-Emmanuel Bellemare and Arnaud Le Troter and Arend Heerschap and David Bendahan},
abstract={Quantitative magnetic resonance imaging can monitor intramuscular fat accumulation and has proven value for follow-up and therapy evaluation of neuromuscular disease. So far, segmentation processes of individual muscles from quantitative MRI data have been recognized as challenging in healthy subjects and even more challenging in patients for whom borders between muscles can be compromised by the disease process. We designed a semi-automatic segmentation pipeline of individual leg muscles in MR images based on automatic propagation of a minimal number of manually segmented MR slices. This segmentation pipeline allows an accurate follow-up of any MRI biomarkers in neuromuscular disorders.}
}
@inproceedings{ISMRM2018_5071,
annote={ISMRM2018_5071},
pages={5071},
file={ISMRM2018_5071.pdf:ISMRM2018_5071.pdf:PDF},
title={How reliable is {DTI} of the lower extremity muscles at high-field (3T) and ultra-high-field (7T) {MRI}?},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5071.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Chiara Giraudo and Stanislav Motyka and Michael Weber and Thorsten Feiweier and Siegfried Trattnig and Wolfgang Bogner},
abstract={The feasibility of DTI at 7T was already demonstrated for brain and muscles but, to date, the assessment of its reliability for calf muscles and a comparison with the reliability at 3T were still missing.Our results showed excellent ICCs(>.750) at 7T and 3T mainly for single muscles(e.g.,gastrocnemii’s tracks number).The comparison of absolute differences of the two consecutive measurements with each device demonstrated similar variability except for tracks’ number of the whole-calf(lower absolute difference at 7T;p=0.034) and FA of the gastrocnemius lateralis(lower absolute difference at 3T;p=0.032).Larger studies should further assess the overall performance of 7T for specific healthy and injured muscles.}
}
@inproceedings{ISMRM2018_5072,
annote={ISMRM2018_5072},
pages={5072},
file={ISMRM2018_5072.pdf:ISMRM2018_5072.pdf:PDF},
title={{SVD} Compression for Quantification of 31P Relaxation Time and Creatine Kinase Reaction Rate by 31P Magnetic Resonance Fingerprinting},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5072.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yuning Gu and Mingrui Yang and Charlie Y. Wang and Debra F. McGivney and Mark A. Griswold and Xin Yu},
abstract={Magnetic resonance fingerprinting (MRF) provides the opportunity for efficient quantification of ATP synthesis using
31P magnetization transfer (MT) spectroscopy. However, the multi-compartment, multi-parametric nature of
31P MT experiments renders dictionary-matching computationally infeasible. In this study, singular value decomposition was employed for parameter estimation in a
31P MRF study that quantified creatine kinase activity. Such approach allowed dictionary compression by 16 fold and accelerated parameter matching by up to 80\% without compromising matching accuracy. In vivo experiments on rat hindlimb (N=21) showed a 2.7-fold increase in measurement efficiency comparing to the conventional MT method using saturation transfer.}
}
@inproceedings{ISMRM2018_5073,
annote={ISMRM2018_5073},
pages={5073},
file={ISMRM2018_5073.pdf:ISMRM2018_5073.pdf:PDF},
title={Exercise-induced muscle hypoxia and re-oxygenation in the calf: A comparison between Near Infra-Red Spectroscopy ({NIRS}) and {BOLD} {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5073.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Christopher C Conlin and Jiawei Dong and Stephen Decker and Gwenael Layec and Vivian S Lee and Jeff L Zhang},
abstract={This study compared calf-muscle oxygenation measurements from BOLD MRI and near-infrared spectroscopy (NIRS) in a group of healthy subjects after plantar-flexion exercise. NIRS measurement of deoxyhemoglobin (dHb) was limited to the medial gastrocnemius, while BOLD imaging allowed for R2* mapping of the entire calf. Post-exercise R2* recovery dynamics in the calf indicated significant functional differences between different calf muscle groups. This advantage of BOLD makes it potentially valuable for assessing peripheral arterial disease (PAD), where impairment of muscle function can vary depending on the location of upstream stenosis.}
}
@inproceedings{ISMRM2018_5074,
annote={ISMRM2018_5074},
pages={5074},
file={ISMRM2018_5074.pdf:ISMRM2018_5074.pdf:PDF},
title={Repeatability and Reproducibility of Diffusion Tensor {MRI} and 2-Point Dixon Fat Fraction Measurements in the Muscle},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5074.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Matthew Farrow and Ai Lyn Tan and Maya Buch and Paul Emery and Andrew Grainger and Steven Tanner and John Biglands},
abstract={Muscle deterioration is associated with fat infiltration and alterations in muscle fibrearchitecture. Quantitative MRI measurements may be able to detect subtle muscle changes. However, before these can be considered for research and clinical use, the repeatability and reproducibility of these measurements must be established. 19 healthy participants had two scans separated by 30 minutes and diffusion and fat fraction measurements were obtained in the thigh. Test-retest repeatability, intra-rater repeatabilityand inter-rater reproducibility were assessed. Both diffusion and fat fraction measurements showed excellent repeatability and reproducibility suggesting that these measurements may be sufficiently precise to allow the study of subtle changes in muscle.}
}
@inproceedings{ISMRM2018_5075,
annote={ISMRM2018_5075},
pages={5075},
file={ISMRM2018_5075.pdf:ISMRM2018_5075.pdf:PDF},
title={Skeletal muscle acetylcarnitine in fasting and postprandial state: 1H {MRS} 7T pilot study.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5075.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Radka Klepochová and Martin Gajdošík and Siegfried Trattnig and Michael Krebs and Martin Krššák},
abstract={Acetylcarnitine plays an important role in fat metabolism. A long TE proton magnetic resonance spectroscopy was applied for detection of skeletal muscle acetylcarnitine during the day in fasting and postprandial conditions at whole body 7T MRsystem in the vastus lateralis muscle. Our observation points towards big variations of acetylcarnitine in postprandial state and no significant changes in acetylcarnitine concentrations during the fasting. Moreover, excellent repeatability of the acetylcarnitine 1H MRS based measurement was estimated during three different days in three weeks. Our data emphasize the need for strict standardization of dietary conditions and time point for the measurement of acetylcarnitine.}
}
@inproceedings{ISMRM2018_5076,
annote={ISMRM2018_5076},
pages={5076},
file={ISMRM2018_5076.pdf:ISMRM2018_5076.pdf:PDF},
title={Muscle specific role of acetylcarnitine concentration and {IMCL} accumulation as a marker for long term glycemic control: 3T 1H {MRS} study},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5076.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Radka Klepochová and Magdalena Bastian and Michael Krebs and Siegfried Trattnig and Alexandra Kautzky-Willer and Martin Krššák},
abstract={Acetylcarnitine can be observed non-invasively in 1H MRspectra in skeletal muscle and its inverse relationship to intramyocellular lipids and metabolic markers of chronic hyperglycemia was suggested. This study aimed to compare the acetylcarnitine concentrations and intramyocellular lipids content in tibialis anterior and soleus of four different groups of volunteers with broad range of glycemic control by 1HMRS on 3Tscanner. Differences in the patient phenotype were mirrored by increased intramyocellular lipids in the tibialis anterior and decreased acetylcarnitine in soleus of type2diabetes patients. This muscle specific behavior of intramyocellular metabolites could represent different fiber composition in examined muscles.}
}
@inproceedings{ISMRM2018_5077,
annote={ISMRM2018_5077},
pages={5077},
file={ISMRM2018_5077.pdf:ISMRM2018_5077.pdf:PDF},
title={Drug efficacy monitoring using magnetic resonance imaging in a cancer cachexia model},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5077.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ho-jin Kim and Sun Kyu Park and Jeom Yong Kim and Chul-Woong Woo and Sang-Tae Kim and Kyung Won Kim and Dong-Cheol Woo},
abstract={Most studies in the field of cachexia research show photographs and H\&E-stained sections of hindlimb muscles to demonstrate changes in fat/muscle volume. However, these methods do not capture the global changes in fat/muscle volume in a cachexia model. In this study, we established a cachexia animal model induced by tumor and ant-cancer drug and examined the efficacy of an anticachexia drug by monitoring fat/muscle volume using magnetic resonance imaging (MRI). Our results illustrated that MRI is a useful tool for drug development owing to its ability to monitor fat/muscle volumes in the cachexia model.}
}
@inproceedings{ISMRM2018_5078,
annote={ISMRM2018_5078},
pages={5078},
file={ISMRM2018_5078.pdf:ISMRM2018_5078.pdf:PDF},
title={Intravoxel Inchoerent Motion {MRI} to Evaluate Post-Occlusive Reactive Hyperemia in Calf Muscles},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5078.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Alfonso Mastropietro and Simone Porcelli and Marcello Cadioli and Letizia Rasica and Elisa Scalco and Simonetta Gerevini and Mauro Marzorati and Giovanna Rizzo},
abstract={The main goal of this study was to evaluate changes of IVIM parameters related to muscle perfusion changes occurring in the calf of healthy subjects before, during and after transitory ischemia of lower limb. MRI acquisitions were performed on 11 healthy volunteers on a 3T scanner. IVIM was performed on the right calf before, during and after arterial occlusion. A slight redcutionof D* and fD* was observed during ischemia whereas a significant increase of D*, fD* and D was observed during hyperemia. IVIM appears as a promising tool to evaluate muscle perfusion relatedparameters in ischemia/hyperemia.}
}
@inproceedings{ISMRM2018_5079,
annote={ISMRM2018_5079},
pages={5079},
file={ISMRM2018_5079.pdf:ISMRM2018_5079.pdf:PDF},
title={Anisotropy of water T2* in murine skeletal muscle at rest},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5079.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Aurea B. Martins-Bach and Ericky C. A. Araujo and Pierre G. Carlier},
abstract={Modelling ultra-short TE (UTE) signal decay allows the extraction of multiple T2* components, an interesting approach to evaluate collagen-rich tissues with short T2 values. UTE can be promising to assess skeletal muscle fibrosis, whose non-invasive evaluation is still challenging. There are, though, indications that muscle T2* during ischemia can change when altering muscle orientation in the static magnetic field. Here we showed that muscle T2* at rest is indeed sensitive to muscle positioning in B
0, with variable orientation-dependent changes in different muscles. We hypothesize that muscle structure might lead to orientation-dependent local susceptibility-induced B
0 gradients, resulting in anisotropy of water-T2*.}
}
@inproceedings{ISMRM2018_5080,
annote={ISMRM2018_5080},
pages={5080},
file={ISMRM2018_5080.pdf:ISMRM2018_5080.pdf:PDF},
title={Association of thigh muscle fat infiltration with isometric strength measurements based on chemical shift encoding-based water–fat {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5080.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Thomas Baum and Sarah Schlaeger and Stephanie Inhuber and Florian Kreuzpointer and Michael Dieckmeyer and Friedemann Freitag and Elisabeth Klupp and Barbara Cervantes and Ansgar Schwirtz and Jan S Kirschke and Dimitrios C Karampinos},
abstract={Chemical shift encoding-based water–fat MRI derived proton density fat fraction (PDFF) of the thigh muscles has been emerging as surrogate marker in subjects with osteoarthritis, sarcopenia and neuromuscular disorders. However, little is known about the relationship of thigh muscle PDFF and corresponding muscle strength measurements. The present study demonstrated that PDFF measurements improve the prediction of thigh muscle strength beyond muscle cross-sectional area in healthy subjects. Thus, chemical shift encoding-based water–fat MRI can provide clinically important information and may potentially track early changes in muscles that are not severely atrophied or fattily infiltrated.
}
}
@inproceedings{ISMRM2018_5081,
annote={ISMRM2018_5081},
pages={5081},
file={ISMRM2018_5081.pdf:ISMRM2018_5081.pdf:PDF},
title={Electro-Magnetic Property Mapping Using Kalman Filtering with a Single Acquistion at 3.0 T and 7.0 T {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5081.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Han-Jae Chung and Jong-Min Kim and You-Jin Jeong and Jeong-Hee Kim and Chulhyun Lee and Chang-Hyun Oh},
abstract={The phase-based Electro-Magnetic (EM) MR property imaging such as Quantitative Susceptibility Mapping (QSM) and MR Electric Properties Tomography (MREPT) shows great potential clinically. The main post-processing steps in QSM and MREPT are high-pass filtering and Laplacian of MR images. They, however, cause severe artifacts and noise during conventional calculations. In this work, we propose a novel reconstruction method of EM property MRI using Kalman filter algorithm and show the utility of the proposed method by comparing the imaging results.}
}
@inproceedings{ISMRM2018_5082,
annote={ISMRM2018_5082},
pages={5082},
file={ISMRM2018_5082.pdf:ISMRM2018_5082.pdf:PDF},
title={Development of Carbon Electrodes for Current Density Mapping during {DBS}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5082.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Neeta Ashok Kumar and Munish Chauhan and Rosalind Sadleir},
abstract={We used MR phase mapping techniques in a preclinical DBS model to image current distributions nearby deep brain stimulation electrodes. To avoid safety issues and artifacts associated with imaging typical platinum-iridium (Pt-Ir) DBS leads, we developed custom carbon electrodes. We compared carbon electrode performance to size-matched Pt-Ir and clinical DBS electrodes at 7 T, using uniform phantoms and fixed brain tissue. Artifacts surrounding carbon electrodes were smaller than for Pt-Ir electrodes. Current density distributions derived from phase images were similar for both electrode types in uniform phantoms and fixed tissue.}
}
@inproceedings{ISMRM2018_5083,
annote={ISMRM2018_5083},
pages={5083},
file={ISMRM2018_5083.pdf:ISMRM2018_5083.pdf:PDF},
title={In vivo Current Density and Conductivity Tensor Imaging of Human Brain During {TACS} using {DT}-{MREIT}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5083.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Munish Chauhan and Aprinda Indahlastari and Aditya Kumar Kasinadhuni and Christopher Saar and Bakir Mousa and Kevin Castellano and Thomas H Mareci and Rosalind J Sadleir},
abstract={Knowledge of the electrical properties of brain tissue is key to developing better understanding of whole brain function. In this study, we present the first in vivo images of anisotropic conductivity distribution in the human head, measured at a frequency of ~10 Hz. We used MREIT techniques to encode phase changes caused by transcranial AC current flow (TACS) within the head via two independent electrode pairs. These results were then combined with DTI data to reconstruct full anisotropic conductivity distributions in 5 mm-thick slices of the brains of two participants. Conductivity values recovered in the study were broadly consistent with literature values.}
}
@inproceedings{ISMRM2018_5084,
annote={ISMRM2018_5084},
pages={5084},
file={ISMRM2018_5084.pdf:ISMRM2018_5084.pdf:PDF},
title={Sequences for transceive phase mapping: a comparison study and application to conductivity imaging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5084.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Soraya Gavazzi and Stefano Mandija and Cornelis AT van den Berg and Yulia Shcherbakova and Mick Bennis and Jan JW Lagendijk and Lukas JA Stalpers and Hans Crezee and Astrid LHMW van Lier},
abstract={Electrical properties imaging relies on accurate transceive phase determination. We explored the use of PLANET, an ellipse fitting approach on phase-cycled bSSFP data, for transceive phase mapping for the first time. We compared its accuracy, precision and time-efficiency with conventional SE and bSSFP techniques. Additionally, we reconstructed conductivity maps based on these techniques. We found that bSSFP and PLANET were as accurate as SE, but more precise. Also, bSSFP was the most time-efficient. Nevertheless, banding artefacts corrupting bSSFP transceive phase were, instead, intrinsically removed by PLANET. PLANET had clinically acceptable scan-time and was generally more suitable for conductivity mapping.}
}
@inproceedings{ISMRM2018_5085,
annote={ISMRM2018_5085},
pages={5085},
file={ISMRM2018_5085.pdf:ISMRM2018_5085.pdf:PDF},
title={Noninvasive Assessment of Electrical Conductivity Characteristics of Normal and Diseased Liver Using Electric Properties Tomography},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5085.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Khin Khin Tha and Ulrich Katscher and Kinya Ishizaka and Kohsuke Kudo and Hiroki Shirato},
abstract={The feasibility of Electric Properties Tomography (EPT) in distinguishing between the normal and diseased liver tissues was evaluated. A 2D steady state free precession sequence was used to acquire the RF transceive phase needed for a simplified version of EPT; and a total of 10 dynamic sagittal scans of the liver were obtained under single breath-hold, in 10 healthy volunteers and 11 patients with hepatic lesions. Despite the need of technical improvements, noninvasive electrical conductivity assessment of the liver by EPT was possible. Its potential utility in identifying hepatocellular carcinomas with intratumoral necrosis and/ or high vascularity was also shown.}
}
@inproceedings{ISMRM2018_5086,
annote={ISMRM2018_5086},
pages={5086},
file={ISMRM2018_5086.pdf:ISMRM2018_5086.pdf:PDF},
title={Diffusion Tensor Magnetic Resonance Electrical Impedance Tomography versus Magnetic Resonance Conductivity Tensor Imaging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5086.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Mehdi Sadighi and Figen S. Oktem and B. Murat Eyuboglu},
abstract={In this study, recently proposed diffusion tensor magnetic resonance electrical impedance tomography (DT-MREIT) is compared with magnetic resonance conductivity tensor imaging (MRCTI) using simulated measurements generated by means of a finite element model. Both methods are used to reconstruct conductivity tensor images of an anisotropic conductivity distribution. In DT-MREIT, extra cellular conductivity and diffusivity ratio (ECDR) is recovered from its transverse gradient. In MRCTI, the conductivity tensor is reconstructed from two current profiles by using anisotropic B
z sensitivity (AB
zS) method with a stronger regularization. Reconstructed conductivity images suggest that MRCTI provides better accuracy than DT-MREIT, at lower SNR levels.}
}
@inproceedings{ISMRM2018_5087,
annote={ISMRM2018_5087},
pages={5087},
file={ISMRM2018_5087.pdf:ISMRM2018_5087.pdf:PDF},
title={Transceive Phase Corrected Contrast Source Inversion-Electrical Properties Tomography},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5087.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Peter R.S. Stijnman and Stefano Mandija and Patrick S. Fuchs and Rob F. Remis and Cornelis A.T. van den Berg},
abstract={Contrast Source Inversion Electrical Properties Tomography (CSI-EPT) is an integral-based method that aims to reconstruct tissue electrical properties through an iterative minimization procedure. This method requires complex $B_1^+$ data as input. In practice, however, the transmit phase cannot be measured in MRI-experiments. Only the transceive phase can be calculated from MR-measurements. In this work, the CSI-EPT reconstruction algorithm is reformulated to take the transceive phase into account. This transceive phase correction opens the possibility to exploit higher sensitivity of EPT at higher field strengths with regular quadrature setups. Additionally, for the first time CSI-EPT reconstructions from MR-measurements are shown.}
}
@inproceedings{ISMRM2018_5088,
annote={ISMRM2018_5088},
pages={5088},
file={ISMRM2018_5088.pdf:ISMRM2018_5088.pdf:PDF},
title={Evaluating Validity of {MREPT} Assumptions for 21.1 T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5088.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ghoncheh Amouzandeh and Jens T Rosenberg and Frederic Mentink-Vigier and Nastaren Abad and Samuel Colles Grant},
abstract={This study examines conductivity mapping using MR Electrical Properties Tomography (MREPT) at ultra-high field (21.1 T). The accuracy of reconstructing conductivity using the complex B
1+ field (Full-form) versus only the B
1+ phase (Phase-based) is evaluated. Phantoms containing different NaCl concentrations were tested to compare these reconstructions with actual conductivities measured by dielectric probe at 900 MHz. Also, these methods were evaluated for experiments acquired with volume and surface coil configurations operated in either linear or quadrature transceiver. Conductivity maps of Full-form versus Phase-based MREPT from in vivo MCAO rats were acquired, with both providing similar variations across the ischemic brain.}
}
@inproceedings{ISMRM2018_5089,
annote={ISMRM2018_5089},
pages={5089},
file={ISMRM2018_5089.pdf:ISMRM2018_5089.pdf:PDF},
title={b{SSFP} Phase Correction and its use in {MREPT}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5089.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Safa Ozdemir and Yusuf Ziya Ider},
abstract={Balanced steady state free precision (bSSFP) has various advantages, namely high speed, high SNR, motion insensitivity and eddy current compensation. However, due to the B
0 inhomogeneity, the so called "banding artifact" occurs at certain frequency regions. In this paper, phase correction method for the bSSFP sequence is proposed utilizing B
0 and T
2 maps. As an application, acquired B
0 insensitive phase maps are used to obtain artifact-free conductivity maps.}
}
@inproceedings{ISMRM2018_5090,
annote={ISMRM2018_5090},
pages={5090},
file={ISMRM2018_5090.pdf:ISMRM2018_5090.pdf:PDF},
title={Implementation of Conductivity Tensor Imaging ({CTI}) using {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5090.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Nitish Katoch and Bup Kyung Choi and Saurav ZK Sajib and Hyung Joong Kim and Oh In Kwon and Eung Je Woo},
abstract={Electrical conductivity is a passive material property primarily determined by concentrations of charge carriers and their mobility. The macroscopic conductivity of biological tissue at low frequency may exhibit anisotropy related with its structural directionality. When expressed as a tensor and properly quantified, the conductivity tensor can provide diagnostic information of numerous diseases. Imaging of conductivity distributions inside the human body requires probing it by externally injecting conduction currents or inducing eddy currents. Here we propose a novel method to reconstruct conductivity tensor images using an MRI scanner without any current injection.}
}
@inproceedings{ISMRM2018_5091,
annote={ISMRM2018_5091},
pages={5091},
file={ISMRM2018_5091.pdf:ISMRM2018_5091.pdf:PDF},
title={A Fast and Dedicated First-Order Differencing {EPT} Reconstruction Method},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5091.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Patrick Stefan Fuchs and Stefano Mandija and Peter Stijnman and Wyger Brink and Cornelis van den Berg and Rob Remis},
abstract={A new method for reconstructing electrical properties from $B_1^+$ data based on Maxwell's equations in an E polarized field (found in the midplane of a birdcage coil) is presented. This first-order EPT (foEPT) method uses first order spatial derivatives as opposed to the second order Helmholtz based MR-EPT methods and is thus less susceptible to noise. Furthermore, the method does not rely on any homogeneity assumptions. The method is validated using an in-vivo phantom measurement and compared to an MR-EPT reconstruction. FoEPT conductivity reconstructions show less noise-amplification and less boundary artefacts compared to Helmholtz-based MR-EPT reconstructions.}
}
@inproceedings{ISMRM2018_5092,
annote={ISMRM2018_5092},
pages={5092},
file={ISMRM2018_5092.pdf:ISMRM2018_5092.pdf:PDF},
title={An Explicit Method for {MR}-Based Electrical Properties Reconstruction Free from Their Boundary Values},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5092.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Motofumi Fushimi and Takaaki Nara},
abstract={This paper presents a new explicit reconstruction method for Magnetic Resonance Electrical Properties Tomography (MREPT) in a circular region of interest (ROI) that does not require EP values on the boundary of the ROI. Starting from the complex form of Maxwell's equations, we solved the D-bar equation of the electric field with the Neumann boundary condition. The proposed method reconstructs EPs successfully without giving any knowledge of EP values on the boundary of the ROI. To extend the method to, for example, a rectangular ROI, is our future work.}
}
@inproceedings{ISMRM2018_5093,
annote={ISMRM2018_5093},
pages={5093},
file={ISMRM2018_5093.pdf:ISMRM2018_5093.pdf:PDF},
title={{LCF} Artifact Elimination in cr-{MREPT} using Phased-Array Receive Coil},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5093.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Gulsah Yildiz and Yusuf Ziya Ider},
abstract={Convection-reaction equation based MREPT (cr-MREPT)
1 conductivity images suffer from LCF artifact at low convective field (LCF) regions. Padding
2 method has been proposed to overcome this issue but it requires additional acquisition, prolonging the total time. In this paper, we propose using data from different channels of phased-array receive coil to eliminate LCF artifact without requiring extra acquisitions.}
}
@inproceedings{ISMRM2018_5094,
annote={ISMRM2018_5094},
pages={5094},
file={ISMRM2018_5094.pdf:ISMRM2018_5094.pdf:PDF},
title={Automated Seed Selection for Gradient-based Electrical Properties Tomography and Its in vivo Validation in the Brain},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5094.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yicun Wang and Pierre-Francois Van de Moortele and Bin He},
abstract={Electrical Properties Tomography (EPT) retrieves tissue electrical conductivity and permittivity at Larmor frequency which potentially provides diagnostic information and facilitates subject-specific local SAR estimation. Gradient-based EPT (gEPT) significantly alleviates boundary artifactencountered by conventional EPT methods, yet its implementation requires subjectiveassignment of integration seed points. In this study, we developed an automated seed selection strategy based on locally calculated conductivity values and evaluated the effect of seed number forhuman brain imaging. This new strategy was validated in eight healthy subjects to produce robust and accurate results, paving the path for an unbiased and fully-automated process for EP quantification.}
}
@inproceedings{ISMRM2018_5095,
annote={ISMRM2018_5095},
pages={5095},
file={ISMRM2018_5095.pdf:ISMRM2018_5095.pdf:PDF},
title={Global Maxwell Tomography with Match Regularization for accurate electrical properties extraction from noisy B1+ measurements},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5095.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jose E.C. Serralles and Athanasios G. Polimeridis and Luca Daniel and Daniel K. Sodickson and Riccardo Lattanzi},
abstract={We introduce a new regularization approach, “Match Regularization” and show that in tandem with Global Maxwell Tomography (GMT) it enables accurate, artifact-free volumetric estimation of electrical properties from noisy B1+ measurements. We demonstrated the new method for two numerical phantoms with completely different electrical properties distributions, using clinically feasible SNR levels. Estimated electrical properties were accurate throughout the volume for both phantoms. Our results suggest that GMT with match regularization is robust to noise and can be employed to map electrical properties in phantoms and in vivo experiments.}
}
@inproceedings{ISMRM2018_5096,
annote={ISMRM2018_5096},
pages={5096},
file={ISMRM2018_5096.pdf:ISMRM2018_5096.pdf:PDF},
title={In-vivo validation of water content Electrical Properties Tomography reconstructions in white matter using independent {MR}-{EPT} measurements},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5096.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Stefano Mandija and Petar I Petrov and Jord T Vink and Sebastian F.W. Neggers and Peter R. Luijten and Cornelis A.T. van den Berg},
abstract={MR-Electrical Properties Tomography (MR-EPT) can provide accurate mean conductivity values in large homogeneous tissues such as the white matter, provided sufficient erosion to avoid boundary regions. Water-content-EPT (wEPT) has been recently proposed to reconstruct EPs on a voxel-to-voxel basis. However, wEPT uses an empirical model calibrated with literature EPs values, assumed correct, obtained from ex-vivo probe measurements. In this work, the validity of the model employed in wEPT is verified for white matter conductivity reconstructions by using in the wEPT model calibration the mean white matter conductivity value obtained from in-vivo MR-EPT reconstructions as an independent modality.}
}
@inproceedings{ISMRM2018_5097,
annote={ISMRM2018_5097},
pages={5097},
file={ISMRM2018_5097.pdf:ISMRM2018_5097.pdf:PDF},
title={Error Analysis of Helmholtz-based {MR}-Electrical Properties Tomography},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5097.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Stefano Mandija and Alessandro Sbrizzi and Ulrich Katscher and Peter R. Luijten and Cornelis A.C. van den Berg},
abstract={The numerical error arising from the computation of spatial derivatives using finite difference kernels is investigated for Helmholtz-based MR-Electrical-Properties-Tomography conductivity reconstructions. We show that this numerical error is one major cause of limited accuracy in Helmholtz-based MR-EPT reconstructions, even if mitigation strategies such as Gibbs ringing correction and Gaussian apodization in k-space are adopted. Ultimately, large derivative kernels lead to more noise-robust conductivity reconstructions, at the cost of more spatially-extended boundary errors. If boundaries are not explicitly taken into account during reconstructions, the accuracy of MR-EPT is severely hampered, particularly for spatially convoluted tissues such as the human brain.}
}
@inproceedings{ISMRM2018_5098,
annote={ISMRM2018_5098},
pages={5098},
file={ISMRM2018_5098.pdf:ISMRM2018_5098.pdf:PDF},
title={Spatial resolution of Full cr-{MREPT}: 2D and 3D evaluation},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5098.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yusuf Ziya Ider and Celik Boga and Gulsah Yildiz},
abstract={Determining the spatial resolution (SR) of Magnetic Resonance Electrical Property Tomography (MREPT) is important for assessing its utility in clinical applications. This study aims at finding the SR of Full cr-MREPT which yields images without internal boundary artifact. It is shown by simulations and experimental results that SR in general is determined by the resolution of the MR data. With noise-free simulation data SR is 2-2.5 pixels. With noisy and real data it may go up to 4-4.5 pixels due to Low Pass filtering and regularization. SR appears to be equal in all three directions.}
}
@inproceedings{ISMRM2018_5099,
annote={ISMRM2018_5099},
pages={5099},
file={ISMRM2018_5099.pdf:ISMRM2018_5099.pdf:PDF},
title={A Dictionary-Based Method for Conductivity Tensor Mapping},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5099.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Kathleen M. Ropella-Panagis and Scott J. Peltier and Douglas C. Noll},
abstract={Measuring conductivity tensors provides an additional layer of information as to how tissues in the body conduct electric current. Tissues with anisotropic conductivity values may include white matter tracts and muscle. Measurement of the tensor requires the object to rotate with respect to the main magnetic field of the MRI scanner, but the degree of rotation is severely limited in human subjects. We propose a dictionary-based approach that provides an estimate of the tensor given small rotation angles of the object.}
}
@inproceedings{ISMRM2018_5100,
annote={ISMRM2018_5100},
pages={5100},
file={ISMRM2018_5100.pdf:ISMRM2018_5100.pdf:PDF},
title={In Vitro Imaging of Therapeutic Effect of Curcumin on Liver Cirrhosis using {MR}-based Electrical Conductivity Imaging Method},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5100.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Bup Kyung Choi and Nitish Katoch and In Ok Ko and Ji Ae Park and Jin Woong Kim and Hyung Joong Kim and Oh In Kwon and Eung Je Woo},
abstract={Curcumin has been used for the treatment of inflammatory diseases in oriental medicine and its anti-inflammatory effect was recently reported. In this feasibility study, hepato-protective effect of curcumin was imaged in rat liver cirrhosis model, which was induced with dimethylnitrosamine (DMN). Magnetic resonance (MR)-based electrical conductivity imaging method was applied to evaluate tissue condition associated with protective effect. From electrical conductivity images, damaged liver tissues by DMN showed decreased conductivity than normal liver tissues. In contrast, cirrhotic tissues with curcumin treatment showed increased conductivity which was similar to normal tissue.}
}
@inproceedings{ISMRM2018_5101,
annote={ISMRM2018_5101},
pages={5101},
file={ISMRM2018_5101.pdf:ISMRM2018_5101.pdf:PDF},
title={Contrast source inversion global Maxwell tomography: a technique for electric properties {MR} imaging without phase information.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5101.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Alessandro Arduino and Oriano Bottauscio and Luca Zilberti},
abstract={The possibility to perform MR imaging of the electric properties relying only on the measurable magnitude of transmit sensitivity, without any hypothesis on its phase, is an extremely interesting task pursued by the scientific community in the last years. Here, the adoption of the contrast source inversion technique in the context of the global Maxwell tomography is proposed. The lack of phase information affect the numerical minimisation procedure by introducing local minima in the cost functional. The convergence of the method is restored by the adoption of multi-channel transmit coils, which can increase the data by measuring multiple transmit sensitivities.}
}
@inproceedings{ISMRM2018_5102,
annote={ISMRM2018_5102},
pages={5102},
file={ISMRM2018_5102.pdf:ISMRM2018_5102.pdf:PDF},
title={Dictionary-based Electric Properties Tomography for brain conductivity imaging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5102.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ulrich Katscher and Max Herrmann and Thomas Amthor and Christian Findeklee and Mariya Doneva},
abstract={Electric Properties Tomography (EPT) derives tissue conductivity and permittivity according to the Helmholtz equation via the second derivative of the measured complex B1 map, or by iteratively solving the corresponding forward problem. This abstract presents a different type of EPT reconstruction: the measured B1 map is compared locally with entries of a dictionary, which are small B1 maps of a priori known electric properties. This "dictionary-based EPT" (db-EPT) could be able to solve the transceive phase problem as well as the boundary problem of EPT. This study demonstrates the feasibility of db-EPT by measuring brain conductivity of healthy volunteers.}
}
@inproceedings{ISMRM2018_5103,
annote={ISMRM2018_5103},
pages={5103},
file={ISMRM2018_5103.pdf:ISMRM2018_5103.pdf:PDF},
title={Evaluation of the Noise Behavior of Gradient-based vs. Helmholz-based Reconstruction of Electrical Properties Tomography in Simulation},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5103.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yihe Hua and Ileana Hancu and Seung-Kyun Lee and Teck Beng Desmond Yeo and Jiaen Liu},
abstract={Electrical properties tomography (EPT) is a promising technique that has the potential to generate high resolution images of tissue electrical properties in vivo. One limitation of EPT is its high sensitivity to noise in the measured data. In this study, a comparison was performed between the so-called gradient-based EPT (gEPT) algorithm and the Helmholtz-based EPT method in a simulation. The result suggests significantly improved performance using gEPT and provides useful insight into the noise behavior of various EPT algorithms for optimization of the algorithm design.}
}
@inproceedings{ISMRM2018_5104,
annote={ISMRM2018_5104},
pages={5104},
file={ISMRM2018_5104.pdf:ISMRM2018_5104.pdf:PDF},
title={Mapping the Brain’s water content and low-frequency electrical properties through T1-weighted {MRI} imaging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5104.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Cornelia Wenger and Catherine Tempel-Brami and Hadas Sara Hershkovich and Moshe Giladi and Zeev Bomzon},
abstract={This study investigates the possibility to extend the water-content based electrical properties tomography (wEPT) technique to lower frequencies. The wEPT approach assumes that electrical properties (EP) of brain tissues can be estimated from water-content (WC) which is derived from two T1-weighted MRIs. Adapted wEPT model parameters were evaluated from ex-vivo measurements of calf brain tissue samples. We performed wEPT estimations in an in-vivo rat brain tumor model, followed by ex-vivo measurements of brain extracted samples. Results predict good correlation between WC ex-vivo measurements and in-vivo wEPT estimations. Yet, mapping EPs with wEPT at lower frequencies needs further investigation.
}
}
@inproceedings{ISMRM2018_5105,
annote={ISMRM2018_5105},
pages={5105},
file={ISMRM2018_5105.pdf:ISMRM2018_5105.pdf:PDF},
title={Spin-lock Imaging of 3-o-Methyl-D Glucose (3o{MG}) in Brain Tumors},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5105.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Zhongliang Zu and Xiaoyu Jiang and Junzhong Xu and John C Gore},
abstract={We evaluated the ability of spin-lock imaging to detect the uptake of 3-o-methyl-D-glucose (3oMG) in normal brain and brain tumors in animals. We used $\triangle R_{1\rho}^{diff}$ to isolate the contribution from only the injected agent. We found that $\triangle R_{1\rho}^{diff}$ in tumors increased rapidly after injection, whereas intact brain showed a gradual increase up to 1h. $\triangle R_{1\rho}^{diff}$ was significantly different between tumors and contralateral normal tissues}
}
@inproceedings{ISMRM2018_5106,
annote={ISMRM2018_5106},
pages={5106},
file={ISMRM2018_5106.pdf:ISMRM2018_5106.pdf:PDF},
title={Chemical Exchange Rotation Transfer imaging of Phosphocreatine in Muscle},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5106.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Zhongliang Zu and Eugene C Lin and Elizabeth A Louie and Xiaoyu Jiang and Christopher L Lankford and Bruce M Damon and Mark D Does and John C Gore and Daniel F Gochberg},
abstract={CEST imaging of Creatine has been reported, whereas selective mapping of PCr in vivo has not been implemented. We found that CEST imaging of Creatine may be influenced by other molecules in muscle, but CERT imaging of PCr is more specific and thus should be a better indicator of changes of flux through the CK reaction.}
}
@inproceedings{ISMRM2018_5107,
annote={ISMRM2018_5107},
pages={5107},
file={ISMRM2018_5107.pdf:ISMRM2018_5107.pdf:PDF},
title={Chemical Exchange Saturation Transfer imaging of prostate cancer at 3T: Repeatability and initial results of an acquisition and multi-pool analysis protocol},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5107.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Vincent Evans and Francisco Torrealdea and Marilena Rega and Mina Kim and Mrishta Brizmohun Appayya and Arash Latifoltojar and Shonit Punwani and Xavier Golay and David Atkinson},
abstract={An optimised acquisition and post-processing protocol for multi-pool Lorentzian analysis of CEST data in the prostate at 3T is described. The repeatability of the technique is evaluated in five healthy volunteers and the contrast observed between healthy tissue, TZ tumour and PZ tumour in two prostate cancer patients is evaluated.}
}
@inproceedings{ISMRM2018_5108,
annote={ISMRM2018_5108},
pages={5108},
file={ISMRM2018_5108.pdf:ISMRM2018_5108.pdf:PDF},
title={Toward {CEST} {MRI} of renal masses: protocol optimization and first preliminary data},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5108.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Shu Zhang and Bian Li and Joshua Greer and Ananth J Madhuranthakam and Jochen Keupp and Ivan E Dimitrov and Robert E Lenkinski and Ivan Pedrosa and Elena Vinogradov},
abstract={Chemical Exchange Saturation Transfer (CEST) MRI is emerging as a tool for the studies of human malignancy. However, the translation of CEST into a successful tool for renal cancer characterization has been slow and hampered by technical difficulties associated with body imaging, such as motion, contaminating lipid signals and increased B0 ingomogeneity. Here we optimize CEST protocol for characterization of renal masses and demonstrate CEST measurements are feasible in kidneys using combination of motion synchronization, post-processing registration and lipid artifact removal. In addition, first Renal Cell Carcinoma patient CEST-mDixon data is shown and imaging results are correlated with the pathology.}
}
@inproceedings{ISMRM2018_5109,
annote={ISMRM2018_5109},
pages={5109},
file={ISMRM2018_5109.pdf:ISMRM2018_5109.pdf:PDF},
title={{APT}-{CEST} post Gadolinium. Should it be avoided? Comparison of pre- \& post-Gadolinium {CEST} on glioma at 3T.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5109.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Francisco Torrealdea and Joe Hearle and Vincent Evans and Moritz Zaiss and Ana Carvalho and Anath Shankar and Harpreet Hyare and David Atkinson and Xavier Golay and Anna Barnes and Marilena Rega},
abstract={This study compares APT-CEST between pre- and post-gadolinium in patients with gliomas at 3T and evaluates the feasibility of performing CEST after administration of T1 contrast. The results of the study demonstrate that Gd administration does not significantly affect the quality of the APT-CEST image, encouraging the acquisition of CEST data, even after the administration of T1 contrast agents.}
}
@inproceedings{ISMRM2018_5110,
annote={ISMRM2018_5110},
pages={5110},
file={ISMRM2018_5110.pdf:ISMRM2018_5110.pdf:PDF},
title={Phase-locked {CEST} – Introducing dynamic B0-correction to gag{CEST}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5110.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Johannes Windschuh and Moritz Zaiss and Jae-Seung Lee and Alexej Jerschow and Ravinder Regatte},
abstract={Even a small frequency drift of less than 1Hz/min of the MRI scanner can have a strong impact on gagCEST measurements. We propose a dynamic B
0-correction that tracks the frequency shift using the phase images provided by the GRE readout. We show that this correction eliminates the influence of the frequency drift on gagCEST without the need of additional measurement time allowing higher accuracy, reproducibility and comparability of gagCEST studies.}
}
@inproceedings{ISMRM2018_5111,
annote={ISMRM2018_5111},
pages={5111},
file={ISMRM2018_5111.pdf:ISMRM2018_5111.pdf:PDF},
title={Accelerating {CEST} with Patch-based Global Orthogonal Dictionary Learning},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5111.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Huajun She and Xinzeng Wang and Shu Zhang and Ece Ercan and Jochen Keupp and Anath Madhuranthakam and Ivan Dimitrov and Robert Lenkinski and Elena Vinogradov},
abstract={This work investigates accelerating CEST imaging using patch-based global spatial-temporal dictionary learning (G-KSVD). We extend the dictionary learning for CEST acceleration. CEST data has high spatial-temporal correlation, so we can utilize the global Z-Spectrum information as well as the spatial information to form the global spatial-temporal dictionary. The dictionary is learned iteratively from overlapping patches of the dynamic image sequence along both the spatial and temporal directions. The proposed method performs better than the BCS and k-t FOCUSS methods for both phantom and in vivo brain data at high reduction factor of R=8.}
}
@inproceedings{ISMRM2018_5112,
annote={ISMRM2018_5112},
pages={5112},
file={ISMRM2018_5112.pdf:ISMRM2018_5112.pdf:PDF},
title={Accelerated {CEST} Imaging with Parallel Deep Convolutional Neural Networks},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5112.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Huajun She and Shu Zhang and Xinzeng Wang and Ece Ercan and Jochen Keupp and Anath Madhuranthakam and Ivan Dimitrov and Robert Lenkinski and Elena Vinogradov},
abstract={CEST is a new contrast mechanism in MRI. However, a successful application of CEST is hampered by its slow acquisition. This work investigates accelerating CEST imaging using parallel convolutional neural networks (PCNN). We extend the Cascade-CNN into a multi-channel model and train the network establish a mapping from the multi-coil input to multi-coil output. This work is the first try to apply deep learning and convolutional neural networks technique in accelerating CEST imaging. The in vivo brain results show that the proposed method demonstrates a high quality reconstruction of the MTR
asym maps with different saturation pulses at R=4.}
}
@inproceedings{ISMRM2018_5113,
annote={ISMRM2018_5113},
pages={5113},
file={ISMRM2018_5113.pdf:ISMRM2018_5113.pdf:PDF},
title={Accelerating 3D {CEST} Imaging with Low Rank Sparse Reconstruction},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5113.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Huajun She and Ece Ercan and Shu Zhang and Xinzeng Wang and Jochen Keupp and Anath Madhuranthakam and Ivan Dimitrov and Robert Lenkinski and Elena Vinogradov},
abstract={Chemical exchange saturation transfer (CEST) is a new contrast mechanism in MRI. However, a successful application of CEST is hampered by its slow acquisition especially in the 3D applications. Compressed sensing (CS) is powerful for reconstruction of highly undersampled data. This work implements the 3D pulsed steady-state CEST acquisition sequence and extended the low rank plus sparse (L+S) method to a 3D version. The phantom and in vivo human brain results demonstrate our design has the potential to accelerate the 3D CEST imaging about 4 times.}
}
@inproceedings{ISMRM2018_5114,
annote={ISMRM2018_5114},
pages={5114},
file={ISMRM2018_5114.pdf:ISMRM2018_5114.pdf:PDF},
title={Quantitative Magnetization Transfer Imaging in Murine Kidneys with Renal Artery Stenosis},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5114.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Kai Jiang and Lilach O. Lerman},
abstract={Quantitative magnetization transfer (qMT) imaging was used to measure bound water fraction in mouse kidneys with renal artery stenosis (RAS). MT-weighted images at variable offset frequencies and amplitudes, as well as B
0, B
1 and T
1 maps of control and RAS kidneys, were acquired. A two-pool qMT model was used to estimate the bound water fraction as well as other relaxation and exchange parameters. An increased bound water fraction was found in the cortex, outer medulla and inner medulla of the RAS kidneys. In conclusion, qMT imaging offers potential new biomarkers for assessment of RAS kidneys.}
}
@inproceedings{ISMRM2018_5115,
annote={ISMRM2018_5115},
pages={5115},
file={ISMRM2018_5115.pdf:ISMRM2018_5115.pdf:PDF},
title={Assessing changes in kidney pH in acute kidney injury model using acido{CEST} {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5115.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Atul Singh Minhas and Jack Sharkey and Edward A Randtke and Patricia Murray and Bettina Wilm and Mark "Marty" Pagel and Harish Poptani},
abstract={Kidneys are responsible for regulation of pH homeostasis and cytotoxicity caused by cancer therapeutics can significantly alter renal function and homeostasis. Chemical exchange saturation transfer (acidoCEST) MRI has been proposed to measure tissue pH in-vivo using exogenous contrast agents. In this study, we used the acidoCEST technique to measure changes in kidney pH after acute kidney injury (AKI) in rodents. Typically, CT contrast agents such as Iopamidol (300 mg iodine/mL) are used as CEST contrast agent in acidoCEST MRI. However, the accuracy of acidoCEST using CT contrast agents relies on the delivery of the contrast agent to the target organ. To address this issue, we performed acidoCEST and FAIR-EPI based perfusion imaging to assess pH and blood flow changes in a mouse model of AKI. Results show that perfusion of kidneys affect pH measurements.}
}
@inproceedings{ISMRM2018_5116,
annote={ISMRM2018_5116},
pages={5116},
file={ISMRM2018_5116.pdf:ISMRM2018_5116.pdf:PDF},
title={Detection of the accumulation of mannitol in rat brains using {CEST} {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5116.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jing Liu and Chengyan Chu and Lin Chen and Jia Zhang and Rohit Kumar Srivatava and Piotr Walczak and Jiadi Xu and Peter van Zijl and Miroslaw Janowski and Guanshu Liu},
abstract={Mannitol is a clinically widely-used osmotic agent. Accumulation of mannitol in the interstitium of the brain, however, can cause severe adverse effects. Here we used CEST MRI to detect mannitol directly through its inherently carried exchangeable hydroxyl protons. After comprehensively characterizing the CEST properties of mannitol in vitro, we demonstrated that the intra-arterial infusion of mannitol at an excess dose led to a significantly elevated CEST signal at 0.9 ppm, indicating that CEST MRI has greatclinical potential to be used as a monitoring tool for mannitol treatment.}
}
@inproceedings{ISMRM2018_5117,
annote={ISMRM2018_5117},
pages={5117},
file={ISMRM2018_5117.pdf:ISMRM2018_5117.pdf:PDF},
title={Nuclear Overhauser enhancement effect of low $B_{1}$ power {CEST} {RF} in human brain at 3.0 T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5117.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yuki Kanazawa and Masafumi Harada and Mitsuharu Miyoshi and Ikuho Kosaka and Kotaro Baba and Hiroaki Hayashi and Yuki Matsumoto},
abstract={The purpose of this study is to clarify the relationship between APT and NOE effects derived from CPE fitting of the human brain on a 3 T MR scanner. CEST imaging with different B
1 values of the brain was performed in healthy subjects. The mean NOE values of white matter at 0.5 µT were higher than all regions (P < 0.05). CPE-spectrum shows greater sensitivity for both APT and NOE peaks than conventional Z-spectrum and MTR
asym. It is found that NOE imaging on a 3.0 T scanner is sensitive on low-B
1 power regardless of the CEST fitting process.}
}
@inproceedings{ISMRM2018_5118,
annote={ISMRM2018_5118},
pages={5118},
file={ISMRM2018_5118.pdf:ISMRM2018_5118.pdf:PDF},
title={Glu{CEST} {MRI}: Reproducibility, background contribution and source of glutamate changes in the {MPTP} mouse model of Parkinson’s disease},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5118.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Puneet Bagga and Stephen Pickup and Dan Martinez and Rachelle Crescenzi and Ari Borthakur and Gaurav Verma and Joel Greenberg and John Detre and Hari Hariharan and Ravinder Reddy},
abstract={Glutamate Chemical Exchange Saturation Transfer (GluCEST) MRI provides indirect detection of glutamate in vivo by measuring the exchange of glutamate amine protons with bulk water. The GluCEST contrast is potentially contaminated by a contribution of other metabolites exhibiting proton chemical exchange. We evaluated the reproducibility and background contamination to the GluCEST and source of the GluCEST changes in MPTP mouse model. Approximately 28\% of GluCEST contrast appears to be derived from sources other than glutamate that arealso not detectable by MRS. Glial proliferation caused by neuroinflammation was found to be the cause of elevated glutamate in mice exposed to MPTP.}
}
@inproceedings{ISMRM2018_5119,
annote={ISMRM2018_5119},
pages={5119},
file={ISMRM2018_5119.pdf:ISMRM2018_5119.pdf:PDF},
title={Toward Safer Monitoring of Glucose Transport in a Rat Brain Tumor Necrosis using 3-O-Methyl-Glucose Chemical Exchange-sensitive Spin-Lock Magnetic Resonance Imaging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5119.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Julius Juhyun Chung and Moon-Sun Jang and Geun Ho Im and Wonmin Choi and Tao Jin and Seong-Gi Kim and Jung Hee Lee},
abstract={Glucose exchange-sensitive spin lock imaging has been shown to have promise in monitoring glucose uptake with reasonable sensitivity. There are design choices that can be made in such an experiment such as whether to use an analog for better sensitivity and how to establish an efficient spin-lock. We examine metabolic uptake of a rat brain tumor with necrosis using 3-O-methyl-glucose, a safer glucose analog than 2DG and examine differences between using an adiabatic pulse and a paired self-compensated pulse with lower peak power. Both pulses demonstrated delayed uptake in the infarcted tumor region although with higher sensitivity using adiabatic pulses.}
}
@inproceedings{ISMRM2018_5120,
annote={ISMRM2018_5120},
pages={5120},
file={ISMRM2018_5120.pdf:ISMRM2018_5120.pdf:PDF},
title={Magnetization Transfer in Lipids - Role of Exchangeable Groups and Water Binding},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5120.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Weiqi Yang and Jae-Seung Lee and Johannes Windschuh and Maureen Leninger and Nate Traaseth and Alexej Jerschow},
abstract={We study the magnetization exchange mechanism in lipid systems, with relevance to imaging myelin via MT contrast. Studies of samples with different lipid compositions reveal exchange time scales and the role of structural features in the contrast mechanism. Insights from molecular dynamics provide estimates of the contribution of the dipolar pool equilibration to the MT amplitude. The effect of lipid head groups and the contribution of cholesterol and proteins are examined. It is hoped that these findings will help explaining the origin of White Matter MT contrast and will allow better myelin quantification by tailored saturation sequences.}
}
@inproceedings{ISMRM2018_5121,
annote={ISMRM2018_5121},
pages={5121},
file={ISMRM2018_5121.pdf:ISMRM2018_5121.pdf:PDF},
title={In vivo Kinetic {CEST} {MRI} of sodium salicylate(Na{SA}): Comparison of {MTR}asym and Subtraction of saturation-weighted images},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5121.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yanrong Chen and Chengwang Jin and Yan Luo and Chongxue Bie and Yingcheng Zhao and Xiaowei He and Xiaolei Song},
abstract={Salicylate analogues feature chemical shift far from water (Δω = 8-10 ppm), however, there are almost no available reports on their in vivo detection of salicylate upon intravenous administration. We aim to optimize the in vivo detection of NaSA, by comparing compared MTRasym and a Dynamic Salicylate Enhancement (DSE). For the mice brain with LPS-induced inflammation, there are ~4\% DSE signal which displays a clear kinetic trend. While MTRasm values are very small, oscillating between -2\% to 0\% due to the unsymetric MTC. In conclusion, our DSE method is able to track the dynamic signal changes following the infusion of NaSA.}
}
@inproceedings{ISMRM2018_5122,
annote={ISMRM2018_5122},
pages={5122},
file={ISMRM2018_5122.pdf:ISMRM2018_5122.pdf:PDF},
title={Assessment of a clinically feasible Bayesian fitting algorithm using a simplified description of Chemical Exchange Saturation Transfer ({CEST}) Imaging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5122.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Aaron Kujawa and Mina Kim and Eleni Demetriou and Annasofia Anemone and Dario Longo and Moritz Zaiss and Xavier Golay},
abstract={A Bayesian fitting algorithm was combined with analytical approximations of the Bloch-McConnell (BM) equations with the aim to considerably reduce processing time. The accuracy of the algorithm was assessed with simulated data and data from phantom experiments and compared to fit results obtained with the numerical solution of the BM equations. Continuous-wave and pulsed saturation was considered. The results showed agreement between estimates and ground truth as well as between the approximate analytical and numerical model implementations of the Bayesian algorithm. A considerable reduction of processing time was achieved.}
}
@inproceedings{ISMRM2018_5123,
annote={ISMRM2018_5123},
pages={5123},
file={ISMRM2018_5123.pdf:ISMRM2018_5123.pdf:PDF},
title={Including water nutation in an analytic solution for pulsed {CEST}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5123.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Christopher Lynn Lankford and Zhongliang Zu and Elizabeth A Louie and Mark D Does and Daniel F Gochberg},
abstract={Pulsed chemical exchange saturation transfer (CEST) MRI lacks an analytical solution, impeding data analysis and optimization efforts. A recently proposed solution has mitigated this problem, but it ignores water pool nutation and is thus inaccurate near the water resonance frequency. This work proposes a solution that accounts for water nutation assuming a known flip angle function which can be numerically estimated with no a priori knowledge about tissue parameters. The nutation-corrected solution closely matches numerical Bloch-McConnell simulation, even near the water resonance frequency.}
}
@inproceedings{ISMRM2018_5124,
annote={ISMRM2018_5124},
pages={5124},
file={ISMRM2018_5124.pdf:ISMRM2018_5124.pdf:PDF},
title={Chemical exchange saturation transfer magnetic resonance imaging of functionalized poly(N, N’-methylene bisacrylamide 4-aminobutanol) gel},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5124.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Weiqiang Dou and Jos M.J. Paulusse and Heinz Peter Janke and Xiaolei Song and Jiadi Xu and J.W.M Bulte and Arend Heerschap},
abstract={Poly (amido amine)s like poly(N, N’-methylene bisacrylamide 4-aminobutanol) (MBA-ABOL) are compounds with promising biomedical applications, which, however, require that they can be visualized without contrast application. In this study we investigated if they can be imaged in a “label free fashion” by CEST MRI making use of their exchangeable amide and hydroxyl protons. We systematically determined optimal conditions for CEST in MBA-ABOL in solution and then demonstrated that the material can be imaged both in vitro and ex vivo, implanted in a rat leg, with a strong CEST effect from the amide protons and substantial effect from the hydroxyl protons.}
}
@inproceedings{ISMRM2018_5125,
annote={ISMRM2018_5125},
pages={5125},
file={ISMRM2018_5125.pdf:ISMRM2018_5125.pdf:PDF},
title={Clinically Feasible Model-based Analysis of Amide Proton Transfer {MRI} in Acute Ischaemic Stroke},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5125.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Paula L. Croal and Yunus Msayib and Kevin J. Ray and James R. Larkin and Brad A. Sutherland and George Harston and Alistair Buchan and Peter Jezzard and James Kennedy and Nicola Sibson and Michael Chappell},
abstract={Model-based analysis of CEST MRI is a robust quantitative method, however, the lengthy acquisition and processing times make it less clinically feasible. It has recently been proposed that partial acquisition of Z-spectra provides a faster approach, but at the cost of increased variability and large alterations in baseline Amide Proton Transfer (APT) effect. Here we present a refined approach, accounting for magnetisation transfer effects, which reduces acquisition and processing times and also decreases variability in the data. We demonstrate its ability to detect pathological reductions in the APT effect in both preclinical and clinical cohorts of acute ischaemic stroke respectively.}
}
@inproceedings{ISMRM2018_5126,
annote={ISMRM2018_5126},
pages={5126},
file={ISMRM2018_5126.pdf:ISMRM2018_5126.pdf:PDF},
title={Improved quantification of amide proton transfer effect with direct water saturation- and magnetization transfer-correction in a glioma rat model at 3 Tesla},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5126.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yin Wu and Yinsheng Chen and Yiying Zhao and Shasha Yang and Jing Zhao and Zhongping Chen and Phillip Zhe Sun},
abstract={Quantification of in vivo APT effect with routine asymmetry analysis is problematic due to concomitant contributions. Herein, a steady-state CEST signal solution was utilized to estimate direct water saturation (DWS) to improve Z-spectral quantification in a pulsed-RF CEST imaging. Specifically, APT effect was measured from the DWS and magnetization transfer (MT)-corrected CEST signals in glioma rat brains post-chemoradiotherapy at 3 Tesla. The proposed method revealed significant APT signal difference among regions of control (3.13±0.38\%), necrosis (3.95±0.31\%) and tumor (4.56±0.34\%), consistent with histological observations and superior than routine asymmetry analysis.}
}
@inproceedings{ISMRM2018_5127,
annote={ISMRM2018_5127},
pages={5127},
file={ISMRM2018_5127.pdf:ISMRM2018_5127.pdf:PDF},
title={In-vivo Z-spectra acquisition with decreased direct saturation using adiabatic spin-lock pulses at 9.4T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5127.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Kai Herz and Chirayu Gandhi and Klaus Scheffler and Moritz Zaiss},
abstract={Off-resonant spin-lock imaging enables a lot of possibilities for T
1ρ and chemical exchange (CE) sensitive applications. For this purpose, a matching amplitude of the tipping and the locking pulse is required, which can be difficult due to the high power requirements of adiabatic pulses. In this work, we present a newly shaped adiabatic half-passage pulse, usable at low power to match the amplitude of the pulses. Off- and on-resonant saturated images acquired at 9.4T are shown. The new pulse shape is able to generate robust images with comparatively low power at ultra-high-field strengths.}
}
@inproceedings{ISMRM2018_5128,
annote={ISMRM2018_5128},
pages={5128},
file={ISMRM2018_5128.pdf:ISMRM2018_5128.pdf:PDF},
title={Optimization of overlap-resolved {CEST} for specific mapping of Glutamate and {GABA}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5128.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Frederico Severo and Noam Shemesh},
abstract={Glutamate-CEST (GluCEST) has been recently emerging as a powerful new technique for mapping Glutamate in the brain. A recent development termed overlap-resolved CEST (orCEST) has demonstrated that other metabolites may contaminate GluCEST contrast and proposed how to resolve the wanted signals; here we optimize orCEST contrast to reflect Glutamate and GABA with very high sensitivity and good specificity. orCEST experiments are optimized on metabolite phantoms and then are applied in-vivo in the rat. The results are promising for neurotransmitter mapping in-vivo.
}
}
@inproceedings{ISMRM2018_5129,
annote={ISMRM2018_5129},
pages={5129},
file={ISMRM2018_5129.pdf:ISMRM2018_5129.pdf:PDF},
title={Non-invasive Detection of {NADH}+{NAD}+ in Human Muscle Using 31P {MR} Spectroscopy at 3T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5129.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Rajakumar Nagarajan and Miles Bartlett and Kwan-Jin Jung and Jane A Kent and Nagendra Yadava},
abstract={NAD+ and NADH act as coenzymes in metabolic reactions. The reduction of NAD+ to NADH is linked with generation of ATP through glycolysis and oxidative phosphorylation. The consumption of NAD+ by various signaling proteins regulates protein modification, cell fate and survival. Therefore, NAD+ and NADH measurements have the potential to inform about tissue energetics and health. Recently, some investigators have suggested that NADH and NAD+ may be detected in human muscle using 31-phosphorus MRS. However, the utility and reliability of this measure is not clear. The goals of this project were to 1) determine whether the NADH+NAD peak can be resolved in human skeletal muscle at 3T, 2) compare peak resolution with and without a decoupling technique and 3) evaluate the reliability of this measure. Interpretation of these data and their potential for studying alterations in NAD+ and NADH homeostasis in human muscle remain to be determined.}
}
@inproceedings{ISMRM2018_5130,
annote={ISMRM2018_5130},
pages={5130},
file={ISMRM2018_5130.pdf:ISMRM2018_5130.pdf:PDF},
title={Altered Microcirculation and Oxygenation of Skeletal muscle in Type 2 Diabetes Mellitus (T2{DM}) Rhesus Monkeys with Non-contrast {MRI} Perfusion and Oximetry Techniques},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5130.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yushu Chen and Li Gong and Yu Zhang and Wen Zeng and Jie Zheng and Fabao Fao},
abstract={In this study, the altered microcirculation and oxygenation of skeletal muscle in T2DM rhesus monkeys were evaluated by non-contrast skeletal muscle MR perfusion and oximetry techniques. We found that the perfusion of skeletal muscle decreased, especially in fast-twitch fiber muscles and with an air-cuff caused muscle hyperemia, the ability to reperfusion in slow-twitch muscle is higher than in fast-twitch muscle. The oxygen extraction fraction of skeletal muscle significantly increased in all skeletal muscle angiosomes. These results suggest the diverse adaptation of slow- and fast-twitch skeletal muscles to T2DM.}
}
@inproceedings{ISMRM2018_5131,
annote={ISMRM2018_5131},
pages={5131},
file={ISMRM2018_5131.pdf:ISMRM2018_5131.pdf:PDF},
title={OpenForce {MR}: A Low-Cost Open-Source {MR}-Compatible Force Sensor},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5131.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Francesco Santini and Oliver Bieri and Xeni Deligianni},
abstract={This work presents an open design for a low-cost (100 USD) MR-compatible force sensor to be used in the context of dynamic muscle MRI/MRS. The sensor is both based on commercial nonmagnetic components and custom manufactured parts. The electronics is realized using Arduino and a prototype software interface is presented. The sensor is calibrated using a commercial dynamometer and shows good linearity in the sensitivity. The setup is proven to function in an MR environment without disturbing the signal acquisition.}
}
@inproceedings{ISMRM2018_5132,
annote={ISMRM2018_5132},
pages={5132},
file={ISMRM2018_5132.pdf:ISMRM2018_5132.pdf:PDF},
title={Multi-Nuclei Functional Imaging of the Skeletal Muscle during Synchronized Electrical Stimulation: Interleaving 1H Velocity Mapping with 31P Spectroscopy},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5132.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Francesco Santini and Dirk Fischer and Oliver Bieri and Xeni Deligianni},
abstract={In this work, we present a novel multi-nuclei interleaved acquisition sequence that acquires three-directional phase contrast images and phosphorus spectra during muscle exercise. The sequence is combined with electrical muscle stimulation to achieve a comprehensive investigation method of the functionality of the skeletal muscle.}
}
@inproceedings{ISMRM2018_5133,
annote={ISMRM2018_5133},
pages={5133},
file={ISMRM2018_5133.pdf:ISMRM2018_5133.pdf:PDF},
title={Diffusion, perfusion and T2 analyses of lower leg muscles after intermittent pneumatic compression},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5133.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Kento Furihata and Tosiaki Miyati and Naoki Ohno and Yuki Hiramatsu and Yurina Ohta and Toshifumi Gabata},
abstract={Although the IPC supposedly changes regional muscle functions, this mechanism has not been clarified. Therefore, to quantitatively assess the effect of IPC, we simultaneously acquired functional information on diffusion, perfusion and transverse relaxation time (T
2) for lower-leg muscles before and after IPC using single-shot diffusion echo-planar imaging (SSD-EPI) with different b-values and echo times (TE). IPC reduces water molecule diffusion in the soleus muscle. Our method makes it possible to simultaneously obtain regional functional information on diffusion, perfusion and T
2 in lower-leg muscles before and after IPC.}
}
@inproceedings{ISMRM2018_5134,
annote={ISMRM2018_5134},
pages={5134},
file={ISMRM2018_5134.pdf:ISMRM2018_5134.pdf:PDF},
title={3D Fiber Aligned Strain Rate: Application to Unilateral Limb Suspension Induced Atrophy},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5134.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Usha Sinha and Vadim Malis and Shantanu Sinha},
abstract={2D and 3D strain rate imaging has been recently introduced to study local tissue deformations. The strain rate tensors are represented in the principal basis while further relevant physiological information can be obtained by extracting 3D strain rate tensors in the muscle fiber basis; the latter is determined by diffusion tensor imaging. Here, we present the methodological developments to extract 3D fiber aligned strain rate images and application to study atrophy induced by Unilateral limb suspension. FASR indices were much smaller than those extracted in the principle basis and further studies are required to understand FASR changes with suspension.}
}
@inproceedings{ISMRM2018_5135,
annote={ISMRM2018_5135},
pages={5135},
file={ISMRM2018_5135.pdf:ISMRM2018_5135.pdf:PDF},
title={Signal-to-Noise Assessment for Diffusion Tensor Imaging of Muscles Using Single Data Set},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5135.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Zhiyue J. Wang and Jin Yamamura and Sarah Keller},
abstract={The DTI metric are prone to bias if the SNR is too low, such as in muscular dystrophies where fat infiltration decreases the partial volume of the muscle. DTI is usually acquired using parallel imaging so the noise level from the background air space is unreliable for SNR assessment. SNR can be measured using a difference image method from 2 image sets acquired repeatedly, but in many studies only one data set is acquired. Here high-pass k-space filtering method for measuring SNR of muscle DTI from single data set was optimized using a difference image method as reference.}
}
@inproceedings{ISMRM2018_5136,
annote={ISMRM2018_5136},
pages={5136},
file={ISMRM2018_5136.pdf:ISMRM2018_5136.pdf:PDF},
title={Reproducibility of calf-muscle perfusion measurements from dynamic contrast-enhanced {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5136.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Christopher C Conlin and Jiawei Dong and Stephen Decker and Nan Hu and Mariya A Chadovich and Michelle T Mueller and Lillian L Khor and Christopher J Hanrahan and Gwenael Layec and Vivian S Lee and Jeff L Zhang},
abstract={This study examined the reproducibility of calf-muscle perfusion measurements from DCE-MRI following plantar-flexion exercise, which is a promising technique for assessing calf-muscle function and viability. In a group of healthy subjects, the same post-exercise DCE-MRI protocol was repeated on two different days and calf-muscle perfusion measurements were compared between the two visits. High correlation and agreement of perfusion between visits was observed for the posterior calf muscles, demonstrating that a plantar-flexion exercise protocol followed by DCE-MRI is suitable for achieving precise measurements of calf-muscle perfusion.}
}
@inproceedings{ISMRM2018_5137,
annote={ISMRM2018_5137},
pages={5137},
file={ISMRM2018_5137.pdf:ISMRM2018_5137.pdf:PDF},
title={Deformable registration of calf muscle {MRI} using an improved Demons approach},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5137.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Sarath Chintalapati and Christopher C Conlin and Gwenael Layec and Stephen T Decker and Nan Hu and Jiawei Dong and Christopher Hanrahan and Michelle Mueller and Lillian Khor and Vivian S Lee and Jeff L Zhang},
abstract={Lower-extremity peripheral arterial disease (PAD) as a major clinical problem and MRI, which measures multiple aspects of the function of the calf muscles, such as muscle perfusion and oxygenation has not been significantly used for this. The reason being no efficient scanning and processing to compare data acquired during the course of treatment. Here we propose to register the calf MRI images using a modified Demons registration method which is more efficient. This method involves first a fast rigid registration and then the Demons deformable registration, by first applying rigid translation and rotation which substantially improved the registration performance for the calf muscle images.}
}
@inproceedings{ISMRM2018_5138,
annote={ISMRM2018_5138},
pages={5138},
file={ISMRM2018_5138.pdf:ISMRM2018_5138.pdf:PDF},
title={The interplay of {MRS} measured skeletal muscle acetylcarnitine, mitochondrial function and glucose availability},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5138.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Anne Tonson and Robert W Wiseman and Ronald A Meyer and Taylor Ann Callahan and Ashley Lang and Jill M Slade},
abstract={Recently resting muscle acetylcarnitine content (AC) has been proposed as a marker for peripheral insulin resistance. However, muscle oxidative capacity and glucose availability may largely contribute to interindividual AC fluctuations independent of peripheral insulin sensitivity. In this study we monitored resting muscle AC in healthy subjects using
1H MRS in response to carbohydrate ingestion and examined the relationship of fasting muscle AC to muscle oxidative capacity measured by
31P MRS. Our results show a strong relationship between mitochondrial capacity and fasting muscle AC and also show that carbohydrate ingestion causes a rapid sharp decline in muscle AC.}
}
@inproceedings{ISMRM2018_5139,
annote={ISMRM2018_5139},
pages={5139},
file={ISMRM2018_5139.pdf:ISMRM2018_5139.pdf:PDF},
title={Rectus capitis posterior minor and nuchal ligament work as a mydural bridge complex-from 3D {MR} Imaging in vivo},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5139.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Mei-yu Sun and Ai-lian Liu and Qing-wei Song and Li-Zhi Xie and Sheng-bo Yu and Hong-jin Sui},
abstract={Myodural bridges (MDB) are soft tissue connections crossing the cervical epidural space to link suboccipital muscles, ligament and cervical dura. It may transmit tensile force from its connection components to dura mater which correlates with spinal cord circulation and chronic headache. The MDB was first described as a dense connective tissue bridge located between the rectus capitis posterior minor (RCPmi) muscle and the spinal dura. RCPmi mass has been suggested as a biomechanical contributor to injury severity in mild traumatic injury and cervicogenic headache. The fibers from nuchal ligament (NL) have also been demonstrated to attach to the cervical dura mater and may affect the RCPmi muscle mass. However, the correlation between RCPmi and NL remains unclear and is investigated in this work.}
}
@inproceedings{ISMRM2018_5140,
annote={ISMRM2018_5140},
pages={5140},
file={ISMRM2018_5140.pdf:ISMRM2018_5140.pdf:PDF},
title={A static {MR} follow-up study of injured levator ani muscle recovery},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5140.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={yujiao zhao and wen shen and zhizheng zhuo},
abstract={The abnormal structure or function of Levator ani muscle(LAM) is the basis for pelvic floor dysfunction disease. Our study is to assess the recovery of injured LAM resulting from vaginal delivery by using static MRI.The primiparas who presented LAM injury at six weeks after delivery were brought into MRI follow-up study(reviewed at three months and six months).54 pubovisceralis injury with edema in a bilateral summary, there was significant difference among different postpartum time points. To summarise, the injured LAM has the ability to recover after delivery. LAM edema may exaggerate the true severity and extent of LAM injury.}
}
@inproceedings{ISMRM2018_5141,
annote={ISMRM2018_5141},
pages={5141},
file={ISMRM2018_5141.pdf:ISMRM2018_5141.pdf:PDF},
title={Quantitative and qualitative analysis of paraspinal back muscle with focus on fat content using {CT} and {MRI} in asymptomatic volunteers},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5141.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Eun Kyung Khil and Jung-Ah Choi and Eunjin Hwang and Sabrilhakim Sidek and Jang Gyu Cha and Il Choi},
abstract={MRI and CT can be reliably used for qualitative and quantitative analysis of para-spinal back muscles in healthy volunteers, especially regarding fat content. Good correlation was found between the two methods. Female gender and older age were associated with higher fat content of para-spinal back muscles.}
}
@inproceedings{ISMRM2018_5142,
annote={ISMRM2018_5142},
pages={5142},
file={ISMRM2018_5142.pdf:ISMRM2018_5142.pdf:PDF},
title={Reproducibility of {MR} elastography of lumbar paraspinal muscle in healthy volunteers},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5142.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Chia-Hui Chen and Chien-Kuo Wang},
abstract={The abnormal tissue stiffness of lumbar paraspinal muscle in symptomatic patients can be diagnosed by palpation in clinical practice. MRE can measure tissue stiffness quantitatively and noninvasively. The objective of this pilot study was to evaluate the reproducibility of MRE of lumbar paraspinal muscles in healthy volunteers. The strong positive relationship between 2 MRE exams was demonstrated by the Pearson's correlation coefficient.}
}
@inproceedings{ISMRM2018_5143,
annote={ISMRM2018_5143},
pages={5143},
file={ISMRM2018_5143.pdf:ISMRM2018_5143.pdf:PDF},
title={Variation of Strain Rate with Force Output in the Medial Gastrocnemius During Isometric Contractions in Young and Senior Subjects},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5143.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Shantanu Sinha and Vadim Malis and Usha Sinha},
abstract={Strain rate tensor mapping can be conveniently computed from velocity encoded phase contrast imaging. It provides a tool to explore local tissue deformations including the magnitude and directions of the principal axes of deformations. The study of the variation of strain rate indices with force output (\% Maximum Voluntary Contraction (MVC) can provide additional information similar to stress-strain relationships measured at the whole muscle level. Here, we present the methodological developments to extract 2D Strain rate indices as a function of \%MVC in 6 normal young (3) and senior (3) subjects. An approximately linear variation of SR indices with \%MVC force was seen in the range of 20-50\% MVC in young and senior subjects.}
}
@inproceedings{ISMRM2018_5144,
annote={ISMRM2018_5144},
pages={5144},
file={ISMRM2018_5144.pdf:ISMRM2018_5144.pdf:PDF},
title={Muscle Activation using 3D Cones Sodium, T2-Weighted Imaging and T2 Mapping: Comparison of Techniques},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5144.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Logan Thorneloe and Neal Bangerter and Victoria Violette and Clint Frandsen and Michael Mendoza and Wayne Johnson and Grayson Tarbox},
abstract={We present a comparison of muscle functional magnetic resonance imaging (mfMRI) techniques in order to determine the most accurate method of measuring muscle activation via MRI that is practical and easy-to-use in numerous research environments.}
}
@inproceedings{ISMRM2018_5145,
annote={ISMRM2018_5145},
pages={5145},
file={ISMRM2018_5145.pdf:ISMRM2018_5145.pdf:PDF},
title={Diffusion tensor imaging of the human calf in healthy and diseased subjects during plantar-flexion exercise},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5145.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Masoud Edalati and Christopher Sorensen and Mary K Hastings and Mohamed Zayed and Michael Mueller and Jie Zheng},
abstract={This study aims to elucidate diffusion variations between human healthy and diseased calf muscles. Subjects were assigned into three groups: healthy, diabetes mellitus (DM) and peripheral artery disease (PAD). DTI echo planar imaging was performed at rest and ankle plantar-flexion to provide fractional anisotropy (FA), mean diffusivity (MD) and fiber length for calf medial gastrocnemius (MG), lateral gastrocnemius (LG) and soleus (SOL). Our initial results revealed noticeable diffusion indices variations from resting to contraction of the above muscles between healthy and diseased groups and demonstrated a good accordance with previous healthy studies in the literature.}
}
@inproceedings{ISMRM2018_5146,
annote={ISMRM2018_5146},
pages={5146},
file={ISMRM2018_5146.pdf:ISMRM2018_5146.pdf:PDF},
title={Real-time {MRI} of the larynx: detecting phonation contrasts},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5146.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Sarah E Johnson and Marissa Barlaz and Shuju Shi and Ryan K Shosted and Brad P Sutton},
abstract={The present study assesses the ability of rt-MRI to detect subtle laryngeal configuration changes during varying phonation contrasts. One subject lay supine within a 3T Siemens Trio scanner while producing a variety of phonation types including breathy, modal and creaky voice. An analysis of axial and coronal slices of the larynx detected predictable changes at the ventricular folds, vocal folds and arytenoid cartilages. We conclude that rt-MRI of the larynx may have further application in the study of phonation in both research and clinical settings as a non-invasive measure of laryngeal function.}
}
@inproceedings{ISMRM2018_5147,
annote={ISMRM2018_5147},
pages={5147},
file={ISMRM2018_5147.pdf:ISMRM2018_5147.pdf:PDF},
title={Can 5-Minute 3D Isotropic Turbo Spin-Echo {MR} Imaging Replace 2D Standard Knee {MR} Imaging at 3T?},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5147.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Seung hee Han and Na Hye Han and Won-Hee Jee and Joon-Yong Jung and Jun-Pyo Myoung and Yoonho Nam and Young In and Won-Hee Jee},
abstract={2D TSE intermediate(IM) or T2-weighted images have been traditionally used to evaluate internal derangements of knee. However partial volume effect due to relatively thick image section and gap and long acquisition time due to impossible reformation is limitation of standard 2D TSE technique. Newly developed 3D isotropic T2 or IM weighted image is made by isotropic voxel data, which allows 3D reformation and reduce acquisition time. The purpose of this study is to compare the image quality and diagnostic performance of 5-minute sagittal fat-suppressed 3D isotropic turbo spin-echo sequence (MSK VIEW) and 2D standard knee magnetic resonance (MR) imaging at 3T.}
}
@inproceedings{ISMRM2018_5148,
annote={ISMRM2018_5148},
pages={5148},
file={ISMRM2018_5148.pdf:ISMRM2018_5148.pdf:PDF},
title={Rapid enhanced {SPI} imaging using inductively coupled local coils for metal artifact reduction},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5148.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Alexander Storm and Kilian Stumpf and Tobias Speidel and Jan Paul and Jan Bernd Hövener and Volker Rasche},
abstract={As a pure phase encoding technique, Single Point Imaging (SPI) has a great potential to reduce metal-induced artifacts, at the cost of long acquisition times normally not suited for clinical use. In this contribution, we present an approach combining SPI with reduced field-of-view imaging and SPARSE-SENSE reconstruction techniques, by using inductively coupled coils (ICC) for local signal boosting and multi-element receive coils. Initial phantom and in-vivo results show reduced metal artifacts at clinically acceptable scan times with the proposed techniques.}
}
@inproceedings{ISMRM2018_5149,
annote={ISMRM2018_5149},
pages={5149},
file={ISMRM2018_5149.pdf:ISMRM2018_5149.pdf:PDF},
title={{MAVRIC} {SL} Compressed Sensing {STIR} Imaging using a Total Generalized Variation ({TGV}) Reconstruction},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5149.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Suryanarayanan Sivaram Kaushik and Graeme McKinnon and Matthew Koff and Hollis Potter and Kevin Koch},
abstract={3D Multi-spectral imaging sequences like MAVRIC SL have been used overcome susceptibility artifacts caused by metallic hardware. Several studies have attempted to reduce long scan times by using parallel imaging and compressed sensing, but PD images are commonly displayed with evident blurring. MAVRIC STIR images, due to their sparseness, may be more amenable to compressed sensing acceleration. The current work focuses on accelerating MAVRIC SL STIR images using compressed sensing and a total generalized variation reconstruction (TGV).}
}
@inproceedings{ISMRM2018_5150,
annote={ISMRM2018_5150},
pages={5150},
file={ISMRM2018_5150.pdf:ISMRM2018_5150.pdf:PDF},
title={Comparison of {DESS} and conventional clinical sequences for imaging the lumbosacral plexus},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5150.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Daehyun Yoon and Adam Luce Bartret and Peter Cipriano and Brian Andrew Hargreaves and Sandip Biswal and Amelie Lutz},
abstract={Peripheral nerve imaging with MRI has gained increasing attention for non-invasive detection of nerve diseases. Unfortunately, the current performance of clinical sequences (T2-weighted fast spine echo with fat saturation and other supporting sequences) in spatial resolution, fat-saturation and nerve-vessel distinction is often insufficient to make a convincing diagnosis. We conducted a radiologic review of lumbosacral plexus images from 3D double-echo in steady state (DESS) in comparison with images from conventional sequences in our current clinical protocol. Our results demonstrate the improved nerve visualization with the DESS sequence with comparable sensitivity to pathology.}
}
@inproceedings{ISMRM2018_5151,
annote={ISMRM2018_5151},
pages={5151},
file={ISMRM2018_5151.pdf:ISMRM2018_5151.pdf:PDF},
title={A New Contrast Mechanism for Parametric Segmentation of {MRI} Using Alternating {RF} Pulses in b{SSFP} Sequence},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5151.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Joonsoo Kim and Hyunseok Seo and Sungpil Jung and JaeMoon Jo and Seohee So and HyunWook Park},
abstract={Magnetic resonance imaging (MRI) technology offers the most important diagnostic information for musculoskeletal (MSK) disorders, in comparison to other imaging modalities (1). However, human MSK system contains a lot of fat, by which the important tissue signals from the cartilage and the synovial fluid are obstructed. Even with fat suppression techniques, it is still difficult to distinguish tissues having similar proton density (PD), T
1 and T
2 values. In this abstract, a new contrast enhancing method for the color MR image based on parametric segmentation is introduced, using the modified bSSFP pulse sequence.}
}
@inproceedings{ISMRM2018_5152,
annote={ISMRM2018_5152},
pages={5152},
file={ISMRM2018_5152.pdf:ISMRM2018_5152.pdf:PDF},
title={Pressure-Triggered Gated {MRI} Acquisition of a Vibrating Scaled Vocal Fold Model},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5152.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Grayson Tarbox and Cassandra Smith and Bradley D. Bolster and Scott Thomson and Neal Bangerter},
abstract={In this work, we present a technique for MR gated imaging of a scaled model of the vocal folds vibrating in the 13-17 Hz frequency range. The vocal fold model was scaled to roughly 4X human size to decrease the frequency of vibration and make gating feasible. The model contained an embedded grid of markers such that biomechanical motion of the laryngeal model could be accurate tracked across multiple phases of the periodic vibrational cycle.
}
}
@inproceedings{ISMRM2018_5153,
annote={ISMRM2018_5153},
pages={5153},
file={ISMRM2018_5153.pdf:ISMRM2018_5153.pdf:PDF},
title={Inversion-Recovery sat-{UTE} sequence for short-T2 structures positive contrast generation and quantification},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5153.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Lucas Soustelle and Ericky Caldas de A. Araujo and François Rousseau and Jean-Paul Armspach and Pierre G. Carlier and Paulo Loureiro de Sousa},
abstract={Short-T2 structures such as myelin and cortical bone often requires the use of inversion-recovery modules in UTE sequences to provide a selective contrast in the components of interest. The sat-UTE sequence allows for an effective slice selection and avoid issues found in commonly used 2D IR-UTE sequences concerning the use of reshaped half-radiofrequency pulses to achieve a minimal echo time. In this work, we propose to make use of an Inversion-Recovery-prepared sat-UTE sequence to provide a short-T2 positive contrast and quantification in the white matter and in the cortical bone of a fixed mouse head.}
}
@inproceedings{ISMRM2018_5154,
annote={ISMRM2018_5154},
pages={5154},
file={ISMRM2018_5154.pdf:ISMRM2018_5154.pdf:PDF},
title={{MR} Imaging of Patients Receiving Anterior Cervical Discectomy and Fusion Surgery Using {MAVRIC}-{SL}-{STIR} Technique},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5154.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Renjie Yang and Yunfei Zha and Yu Zhang and Changsheng Liu and Yang Fan},
abstract={Metal implants are now very common in modern joint and spine surgeries. However, conventional MR images are significantly compromised by implant-induced magnetic susceptibility artifacts. A novel metal artefacts reduction technique, termed MAVRIC-SL was proposed. The purpose of this study is to evaluate its clinical feasibility and diagnostic value in patients after anterior cervical discectomy and fusion surgery compared with routine 2D FSE images at 3 T. As a result, although the image quality of MAVRIC-SL is limited at 3 T, it can still provide important additional diagnostic information through substantially reduced metal artefacts.}
}
@inproceedings{ISMRM2018_5155,
annote={ISMRM2018_5155},
pages={5155},
file={ISMRM2018_5155.pdf:ISMRM2018_5155.pdf:PDF},
title={Ultra-short echo time ({UTE}) imaging with Three-component fitting analysis of human cortical bone},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5155.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Xing Lu and Saeed Jerban and Michael Carl and Wenhui Yang and Annette von Drygalski and Eric Y Chang and Jiang Du},
abstract={Increased cortical porosity is a major cause of the decreased strength of osteoporotic bone, which can be evaluated by MRI based bone water components analysis. The chemical shift caused by fat in the bone may lead to incorrect estimation of water components with a bi-component exponential model. Thus, we propose a tri-component fitting method for accurate bound and pore water quantification incorporating a multi-peak spectral modeling of fat. Nine human cortical bone samples were studied. Our results suggest improved curve fitting and additional information when a tri-component analyses is used.}
}
@inproceedings{ISMRM2018_5156,
annote={ISMRM2018_5156},
pages={5156},
file={ISMRM2018_5156.pdf:ISMRM2018_5156.pdf:PDF},
title={Image derived arterial input function using popliteal artery for [18F]-sodium fluoride (NaF) {PET}/{MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5156.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Bryan Haddock and Feliks Kogan and Audrey Fan and Charlotte Suetta and Garry Gold},
abstract={This study evaluates the feasibility of performing dynamic [18F]-sodium fluoride (NaF) kinetic studies of the knee using PET/MRI with a focus on determining a robust method to produce an image derived input function (IDIF) using MRI images. Input functions are created using an angiography sequence to isolate the popliteal arteries and create intravascular ROIs centred in the artery to measure blood activity. 12 subjects were given two injections 75 min apart and the derived IDIFs were compared for reproducibility and accuracy. The resulting IDIFs had high reproducibility and gave values matching blood samples and literature values. Given its accuracy and robustness, this technique is well suited for clinical PET/MRI examinations.}
}
@inproceedings{ISMRM2018_5157,
annote={ISMRM2018_5157},
pages={5157},
file={ISMRM2018_5157.pdf:ISMRM2018_5157.pdf:PDF},
title={Time interleaved multi-gradient-echo imaging with {UTE} and non-{UTE} sampling for simultaneous {PDFF}, T2* and magnetic susceptibility mapping of cortical bone},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5157.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Sophia Kronthaler and Maximilian Nikolaus Diefenbach and Stefan Ruschke and Jakob Meineke and Holger Eggers and Peter Boernert and Dimitrios Karampinos},
abstract={Recently, quantitative magnetic susceptibility mapping (QSM) is gaining attention in the context of probing bone microstructure with potential clinical application in the assessment of bone health. Particularly, in bone applications the presence of multiple chemical species including short and long T2* components embedded in the bone environment poses several challenges including rapid signal decay, fieldmap estimation and chemical species separation. Using non-UTE QSM leads to signal voids in cortical bone regions complicating QSM. Therefore, the present study investigates the application of a stack-of-stars time-interleaved multi-gradient echo sequence including UTE and regular echo sampling for bone QSM.}
}
@inproceedings{ISMRM2018_5158,
annote={ISMRM2018_5158},
pages={5158},
file={ISMRM2018_5158.pdf:ISMRM2018_5158.pdf:PDF},
title={Prognostic value of dynamic {MRI} in assessing femoral head vascularity of male smokers.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5158.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={lei hu and yang fan},
abstract={Smokers were at a higher risk of osteonecrosis of the femoral head (ONFH). In this study we aim to evaluate prognostic value of dynamic magnetic resonance imaging in assessing the femoral head vascularity of male smokers. 80 young adult men of whom 40 were smokers and 40 were nonsmokers underwent routine MR and DCE MR examination. The images and data were analyzed. In this study, we found that there was no difference of T1WI and T2WI between smokers and non-smokers. K
trans and K
ep of femoral head in the smoking group were higher compared to the control group. DCE MR can be a potential tool to detect the early change of femoral head vascularity of male smokers.}
}
@inproceedings{ISMRM2018_5159,
annote={ISMRM2018_5159},
pages={5159},
file={ISMRM2018_5159.pdf:ISMRM2018_5159.pdf:PDF},
title={Correlation study between micro-architecture of trabecular bone and magnetic resonance transverse relaxation times at multiple spatial resolutions},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5159.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={DongKyu Lee and Youngkyu Song and Bumwoo Park and Hwapyung Cho and Gyunggoo Cho and HyungJoon Cho},
abstract={The effects of magnetic resonance (MR) imaging resolutions on the correlations between standard trabecular structural indices and MR transverse relaxation-times (T
2 and T
2*) were evaluated by performing Monte Carlo proton diffusion simulations, ex vivo experiments with defatted human trabecular specimens and bovine knee trabecular samples with intact bone marrow via 7T system. T
2 relaxation-time robustly represented the trabecular micro-architecture, such as trabecular spacing and number, while T
2* was vulnerable with degrading spatial resolution. T
2 relaxation times may facilitate the radiation-free diagnosis to assess osteoporotic fractures and therapy response for deep trabecular areas within a feasible scan time on a 7T system.}
}
@inproceedings{ISMRM2018_5160,
annote={ISMRM2018_5160},
pages={5160},
file={ISMRM2018_5160.pdf:ISMRM2018_5160.pdf:PDF},
title={Femoral Head Perfusion Color Mapping using {DCE}-{MRI} in Slipped Capital Femoral Epiphysis: Preliminary Experience},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5160.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Kojiro Ono and Hirofumi Watanabe and Yasuhiro Oikawa and Takumi Okubo and Akira Shirayama},
abstract={There is no established method for diagnosing femoral head necrosis before surgery, because it is difficult to predict AN due to SCFE. In this study, we propose a scheme and optimization to evaluate the femoral head perfusion in children with SCFE. Our objective is to optimize DCE-MRI and to provide useful color maps for diagnosing the femoral head perfusion.Femoral head perfusion color mapping using DCE-MRI in SCFE is useful for decision of surgical treatment method. Color maps of positive enhancement integral and maximum slope of increase contributes to evaluation of perfusion status.}
}
@inproceedings{ISMRM2018_5161,
annote={ISMRM2018_5161},
pages={5161},
file={ISMRM2018_5161.pdf:ISMRM2018_5161.pdf:PDF},
title={Imaging Scoliosis Using Zero Echo Time {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5161.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Chien-Yuan Eddy Lin and Hsiao-Ling Lin and Ya-Lin Fang and Hung-Ta Wu and Chi-Kuang Feng and Wan-You Guo},
abstract={A high resolution, rapid scanning and three-dimensional zero-echo time (ZTE) protocol for cortical bone of whole spine imaging was established in this study. It provides computed tomography-like bone contrast and offers the similar result in the measurement of Cobb angle with conventional radiography, suggesting that the detection scoliosis and measurement of curvature using ZTE is possible, providing a potential alternative radiation-free diagnostic option that is especially relevant to scoliosis patients who need to undergo repeated examinations for evaluating the progress of spinal curvature.}
}
@inproceedings{ISMRM2018_5162,
annote={ISMRM2018_5162},
pages={5162},
file={ISMRM2018_5162.pdf:ISMRM2018_5162.pdf:PDF},
title={Estimating vertebral bone marrow triglyceride unsaturation based on the extraction of the olefinic peak in short-{TE} {STEAM} {MRS} using a constrained fitting model},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5162.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jan Syväri and Stefan Ruschke and Michael Dieckmeyer and Daniela Franz and Hans Hauner and Jan S Kirschke and Thomas Baum and Dimitrios Karampinos},
abstract={The measurement of vertebral bone marrow triglyceride unsaturation using single-voxel STEAM MRS serves as a potential biomarker for bone health. The required quantifiction of the olefinic fat peak (OFP) is often prevented by an overlapping water signal. The aim of this study was to investigate the feasibility of measuring the OFP by defining a quantification reliability measure (QRM) based on the comparison of two constrained triglyceride models. Result: The feasibility of estimating the OFP depends on the water linewidth and proton density fat fraction, increases with the QRM and may not be achievable if the water peak and OFP are not intercepting.}
}
@inproceedings{ISMRM2018_5163,
annote={ISMRM2018_5163},
pages={5163},
file={ISMRM2018_5163.pdf:ISMRM2018_5163.pdf:PDF},
title={Sex dependence of age-related vertebral bone marrow {PDFF} and T2 relaxation time changes in a cohort of nearly 200 subjects using multi-{TE} single-voxel {MR} spectroscopy},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5163.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jan Syväri and Stefan Ruschke and Michael Dieckmeyer and Daniela Franz and Hans Hauner and Jan S Kirschke and Thomas Baum and Dimitrios Karampinos},
abstract={Fat quantification of vertebral bone marrow (VBM) has been often performed with single-TE MRS. Using MRS the differences in the T
2-decay of water and fat is neglected and therefore the extracted fat fraction (FF) measure comprises T
2-weighting. The aim of this study was to examine differences between T
2-weighted FF and proton density fat fraction (PDFF) using multi-TE single-voxel MRS and to relate the observed differences with changes in T
2-relaxation of water with age in 197 subjects. The T
2-relaxation of water remained constant in males and showed an age dependence in females resulting in amplified gender differences of T
2-weighted FF with age compared to PDFF.}
}
@inproceedings{ISMRM2018_5164,
annote={ISMRM2018_5164},
pages={5164},
file={ISMRM2018_5164.pdf:ISMRM2018_5164.pdf:PDF},
title={What is the role of {MRS}-based bone marrow fatty acid unsaturation level compared to fat fraction in predicting vertebral bone strength?},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5164.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Michael Dieckmeyer and Stefan Ruschke and D Anitha and Jan S Kirschke and Dimitrios C Karampinos and Subburaj Karupppasamy and Thomas Baum},
abstract={In addition to bone marrow fat content, bone marrow composition is attracting growing interest as an advanced biomarker in the investigation of osteoporosis and bone metabolism. Finite-element analysis of CT imaging data allows non-invasive assessment of bone fracture risk. The present vertebral specimen study showed that vertebral bone marrow fatty acid unsaturation level (UL) is positively correlated with finite-element analysis based failure load and confirmed the negative correlation between bone marrow fat fraction and failure load. However, UL estimation did not improve failure load prediction beyond bone marrow fat fraction in this in-vitro study.}
}
@inproceedings{ISMRM2018_5165,
annote={ISMRM2018_5165},
pages={5165},
file={ISMRM2018_5165.pdf:ISMRM2018_5165.pdf:PDF},
title={Comparison of cortical bone visualization in the hip using {ZTE} and in-phase 3D gradient echo {MRI} sequences at 3T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5165.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Aiming Lu and Krzysztof R Gorny and Joel P Felmlee and Stephen M Broski and Benjamin Howe},
abstract={Visualizing cortical bone with MRI is challenging, as it appears as signal void in conventional MRI. Both the “black bone” technique and the zero-TE (ZTE) sequence have been proposed for cortical bone visualization. While the “black bone” technique potentially provides better cortical bone to soft tissue contrast, the ZTE sequence enables differentiation from air. This work aimed to compare the two techniques for visualizing cortical bone in the hip. Our results show that cortical bone visualization was compromised using the “black bone” technique due to chemical shift artifacts, while ZTE MRI delivered excellent depiction of the cortical bone.}
}
@inproceedings{ISMRM2018_5166,
annote={ISMRM2018_5166},
pages={5166},
file={ISMRM2018_5166.pdf:ISMRM2018_5166.pdf:PDF},
title={Cortical Bone Imaging Using Ultrashort Echo Time ({UTE}) Phase Sensitive Dual Inversion Recovery Subtraction Technique},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5166.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yajun Ma and Wei Zhao and Adam Searleman and Nikolaus M Szeverenyi and Jiang Du and Graeme M Bydder},
abstract={Imaging of cortical bone is of fundamental importance in clinical MR but signals are low even with ultrashort echo time (UTE) sequences and contamination with high signals from long T2 muscle and fat is a problem 1. Here we propose a new phase sensitive dual inversion recovery subtraction method to obtain pure cortical bone images with zero signal from surrounding long T2 muscle and fat.}
}
@inproceedings{ISMRM2018_5167,
annote={ISMRM2018_5167},
pages={5167},
file={ISMRM2018_5167.pdf:ISMRM2018_5167.pdf:PDF},
title={Quantitative Dynamic Contrast-enhanced {MR} Imaging in Different Arterial Input Functions and Measurement Dimensions: Which Method Performs Best in differentiation of Malignant from Benign Soft Tissue Tumors?},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5167.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jimin Yoon and Won-Hee Jee and Jun-Pyo Myoung and Joon-Yong Jung and Chan Kwon Jung and Yang-Guk Chung},
abstract={This study was designed to evaluate the reliability of quantitative dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) according to the different arterial input functions (AIF) at different measurement dimensions in differentiating malignant from benign soft tissue tumors at 3T. Quantitative DCE-MRI parameters of either benign or malignant tumors were obtained in three different measurement dimensions: focal early enhancing area, single-slice average and whole tumor volume. They were calculated using three different population-averaged AIF (fast, intermediate and slow) and one of the three AIF of the lowest Chi-square, using SyngoVia software. The result showed quantitative DCE-MRI may be reliable and accurate in differentiating malignant from benign soft tissue tumors at 3T, particularly from focal early enhancing area using intermediate or fast AIF.}
}
@inproceedings{ISMRM2018_5168,
annote={ISMRM2018_5168},
pages={5168},
file={ISMRM2018_5168.pdf:ISMRM2018_5168.pdf:PDF},
title={Differentiation of Pulmonary From Non-Pulmonary Spine Metastases Using Conventional {DCE} Kinetic Analysis and Machine Learning},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5168.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ning Lang and Yang Zhang and Enlong Zhang and Jiahui Zhang and Daniel Chow and Peter Chang and Melissa Khy and Hon J. Yu and Huishu Yuan and Min-Ying Su},
abstract={DCE-MRI of the spine was analyzed to differentiate metastasis from lung cancer (N=30) and other tumors (N=31, 9 breast, 6 prostate, 7 thyroid, 6 liver, 3 kidney). Using DCE parameters measured from the tumor ROI, CHAID decision tree classification selected the wash-out slope of -6.6\% and wash-in SE of 98\% as thresholds, which could achieve diagnostic accuracy of 0.79. In machine learning, the enhanced tumor on DCE image was segmented automatically by using the normalized cut algorithm. The Convolutional Long Short Term Memory (CLSTM) network with all 12 sets of DCE images as the input could yield accuracy of 0.75-0.84.}
}
@inproceedings{ISMRM2018_5169,
annote={ISMRM2018_5169},
pages={5169},
file={ISMRM2018_5169.pdf:ISMRM2018_5169.pdf:PDF},
title={Texture Analysis Based Separation of Osteosarcoma and Ewing’s Sarcoma using Diffusion Weighted {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5169.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Esha Baidya Kayal and Devasenathipathy Kandasamy and Jayendra Tiru Alampally and Sameer Bakhshi and Raju Sharma and Amit Mehndiratta},
abstract={Osteosarcoma(OS) and Ewing’s sarcoma family of tumors(ESFT) are the most common primary malignant bone tumor in children and adolescents. As the patient’s age, presenting signs \& symptoms and qualitative imaging features are common in both, there could be a diagnostic dilemma that can only be resolved by biopsy \& histopathological assessment. Texture analysis in Diffusion Weighted Imaging(DWI) might provide additional useful information as DWI captures early cellular changes within tumors. We computed textural features in patients with OS and ESFT. Experimental results revealed that textural features provided significant discrimination between OS and ESFT; thus might be useful as diagnostic marker.}
}
@inproceedings{ISMRM2018_5170,
annote={ISMRM2018_5170},
pages={5170},
file={ISMRM2018_5170.pdf:ISMRM2018_5170.pdf:PDF},
title={Texture Analysis of Apparent Diffusion Coefficient ({ADC}) Maps of Vertebral Bone Marrow in Patients with Multiple Myeloma: Correlation with Clinical Parameters and the Revised International Staging System},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5170.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Qin Wang and Huadan Xue and Tianyi Qian and Alto Stemmer and Shuo Li and Zhaoyong Sun and Zhengyu Jin},
abstract={This study aimed to correlate textural parameters derived from apparent diffusion coefficient (ADC) maps of bone marrow to clinical parameters and the revised international staging system (R-ISS) in patients with multiple myeloma (MM). Sixty-one patients with MM underwent whole-body DWI. Texture analysis of ADC maps on vertebral bodies extracted five parameters, including mean, standard deviation, entropy, skewness and kurtosis. These parameters were significantly correlated with clinical parameters of disease burden. Entropy showed the highest diagnostic capacity for discriminating R-ISS stage III from stage I/II. ADC-based textural parameters may serve as adjunct tools for detecting MM patients with advanced R-ISS stages.}
}
@inproceedings{ISMRM2018_5171,
annote={ISMRM2018_5171},
pages={5171},
file={ISMRM2018_5171.pdf:ISMRM2018_5171.pdf:PDF},
title={{MRI}, {CT} and histomorphometry co-registration studies: analysis of murine tibia morphology before and after decalcification process},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5171.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Marilena Tauro and William Dominguez-Viqueira and Jan Poleszczuk and Conor C Lynch and Gary Martinez and Mikalai M Budzevich},
abstract={In this work we evaluate the relative merits of MRI and CT to “gold standard” histopathology assessment, with regard to bone tumor metastases. We also investigate the profound effect that decalcification process has on tumor/bone morphology. MRI shows differences in tumor shape before and after decalcifications, however the differences in total tumor volume were smaller than 5 percent. Co-registered microCT images and MR images exhibit displacement of bone-matrix after decalcification. The question of co-registration between all three modalities remains open, however we believe our algorithm minimizes registration errors.}
}
@inproceedings{ISMRM2018_5172,
annote={ISMRM2018_5172},
pages={5172},
file={ISMRM2018_5172.pdf:ISMRM2018_5172.pdf:PDF},
title={Evaluation of the therapeutic effect on multiple myeloma patients using {IDEAL} {IQ}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5172.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yichen Ma and Li Wang and Yanhua Tang and Yang Fan and Tao Jiang},
abstract={Multiple myeloma is the second most common hematologic malignancy which occurs commonly in elderly patients. The alteration of bone marrow microenvironment caused by multiple myeloma may lead to the change of fat content and T2* of the bone. IDEAL IQ is a technique which can simultaneously and quantitatively calculate the fat fraction and R2* value of given tissues. The purpose of this study is to investigate the prognostic value of IDEAL IQ technique for the Blood treatment under M protein test on multiple myeloma.}
}
@inproceedings{ISMRM2018_5173,
annote={ISMRM2018_5173},
pages={5173},
file={ISMRM2018_5173.pdf:ISMRM2018_5173.pdf:PDF},
title={From Bench to Bedside: Improved Detection of Spondylolysis Using 3D Cones Ultrashort Time to Echo ({UTE}) {MR} Technique},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5173.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Tim Finkenstaedt and Suraj Achar and Ibraheem Algarni and Michael Carl and Palanan Siriwanarangsun and Nirusha Abeydeera and Reni Biswas and Sheronda Statum and Christine B. Chung and Won C. Bae},
abstract={Spondylolysis, defined as a bony defect in the pars interarticularis of the vertebral arch, is a frequent condition in the young population in which exposure to ionizing radiation is a major concern. In practice, CT imaging is performed in addition to MRI if spondylolysis is suspected. 3D Cones-based UTE MR techniques providing contrast and resolution similar to CT may have overcome the issue of conventional MR-sequences that do not yield sufficient contrast of short T2 tissues near the pars defect. Our study shows in an exemplary manner that detection of spondylolysis with UTE sequences is feasible in the clinical setting.}
}
@inproceedings{ISMRM2018_5174,
annote={ISMRM2018_5174},
pages={5174},
file={ISMRM2018_5174.pdf:ISMRM2018_5174.pdf:PDF},
title={Fat Saturation in Musculoskeletal {MRI} using Spectral Heterogeneity Adaptive {RF} Pulses ({SHARP})},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5174.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Venkata Veerendranadh Chebrolu and Matthew Frick and Peter Kollasch and Benjamin Schmitt and Vibhas Deshpande and John Grinstead and Daniel Spence and Joel Felmlee and Kimberly K Amrami},
abstract={In this work we propose the use of adaptive RF pulses for achieving uniform fat-saturation (fat-sat) that is robust to B0 and B1 heterogeneity often observed in musculoskeletal MRI. A prototype with Spectral Heterogeneity Adaptive RF Pulses (SHARP) was developed to improve the quality and functionality of fat-sat. SHARP was shown to provide fat-sat with higher robustness to B0 and B1 heterogeneity compared to SPIR and SPAIR fat-sat methodologies.}
}
@inproceedings{ISMRM2018_5175,
annote={ISMRM2018_5175},
pages={5175},
file={ISMRM2018_5175.pdf:ISMRM2018_5175.pdf:PDF},
title={Water/fat separation imaging at 7T using 3D integrated {SSFP}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5175.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Kaibao Sun and Zhentao Zuo and Huilou Liang and Jing An and Danny J.J. Wang and Rong Xue},
abstract={Balanced SSFP (bSSFP) has been used as a new alternative for water-fat separation imaging due to its fast acquisition and high SNR efficiency. However, it displays characteristic banding artifacts in the presence of field inhomogeneity, especially at the 7T ultrahigh-field MRI system. Complex combination of two phase-cycled bSSFP was used to alleviate the artifact at 3T, but would take more scan time. Integrated SSFP (iSSFP), which was modified from bSSFP, was introduced to separate water and fat while removing banding artifacts in shorter scan time. iSSFP also inherited the advantages of relatively high SNR and bright fluid. 3D iSSFP with high spatial resolution may have great potential to separate water and fat in the clinical application of 7T ultrahigh-field MRI.
}
}
@inproceedings{ISMRM2018_5176,
annote={ISMRM2018_5176},
pages={5176},
file={ISMRM2018_5176.pdf:ISMRM2018_5176.pdf:PDF},
title={Protocol for in vivo acquisition and fully-automated segmentation of the anterior cruciate ligament},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5176.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Laura Bernadette Lane and Gabriel della Maggiora and Nicolás Schlotterbeck and Cristián Montalba and Pablo Besa and Sebastián Irarrazaval and Alvaro Burdiles and Pablo Irarrazaval},
abstract={In this preclinical study we propose a protocol for rapid 3D imaging and fully automated segmentation to create a standardized healthy ACL image database. The segmentation problem of the ACL is particularly challenging due to its poor contrast. Our protocol demonstrated promising fully-automated segmentation of the ACL. Thus, allowing us to have a 3D computational model of the ACL. Ongoing experimentation explores dynamic imaging of the ACL in motions of flexion-extension. Such work will improve understanding of in vivo knee mechanics with potential to inform treatment of different injuries related to the ACL.}
}
@inproceedings{ISMRM2018_5177,
annote={ISMRM2018_5177},
pages={5177},
file={ISMRM2018_5177.pdf:ISMRM2018_5177.pdf:PDF},
title={{CPPD}-diseased, Normal and Degenerated Menisci: Biomechanical and quantitative {MRI}-derived Properties},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5177.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Tim Finkenstaedt and Reni Biswas and Nirusha Abeydeera and Palanan Siriwanarangsun and Robert Healey and Sheronda Statum and Won C. Bae and Christine B. Chung},
abstract={Calcium pyrophosphate crystal deposition (CPPD) disease of the knee is a frequent condition in the elderly population that might cause chondrocalcinosis of the fibrocartilaginous menisci. Controversy exists whether chondrocalcinosis of the menisci is a cause or consequence of osteoarthritis. Thus, it would be desirable to determine whether CPPD-afflicted menisci exhibit altered biomechanical properties and if they correlate with quantitative MR values. Purpose of this study is to investigate if CPP deposits alter the biomechanical properties as well as the UTE values of menisci compared to grossly normal and degenerated human menisci.}
}
@inproceedings{ISMRM2018_5178,
annote={ISMRM2018_5178},
pages={5178},
file={ISMRM2018_5178.pdf:ISMRM2018_5178.pdf:PDF},
title={Pre-operative {MRI} for Predicting Clinical Outcome Following Rotator Cuff Tendon Repair Surgery},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5178.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Richard Kijowski and Kevin Lian and Peter Thurlow and Gang Li and Michael Tuite and Fang Liu},
abstract={This study was performed to determine whether pre-operative MRI could provide prognostic information regarding clinical outcome following rotator cuff tendon repair surgery. The study group consisted of 141 patients undergoing surgical repair of a full-thickness rotator cuff tendon tear who completed the Disabilities of Arm, Shoulder and Hand (DASH) and Short Form (SF-12) surveys before and one year after surgery. The pre-operative MRI was reviewed to determine tear size, tear retraction, torn tendon tendinosis and composite muscle atrophy. There was a significant inverse association (p<0.05) between post-operative DASH and SF-12 scores and tear width, tendon retraction and torn tendon tendinosis.}
}
@inproceedings{ISMRM2018_5179,
annote={ISMRM2018_5179},
pages={5179},
file={ISMRM2018_5179.pdf:ISMRM2018_5179.pdf:PDF},
title={Usefulness of non-contrast perfusion using arterial spin labeling ({ASL}) for the differential diagnosis of shoulder pain},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5179.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Katsumi Nakamura and Fumihide Arakami and Tomoko Nishi and Kenichi Inoue and Akiyoshi Yamamoto and Asaka Aso and Mitsue Miyazaki},
abstract={We evaluated the usefulness of non-contrast perfusion obtained using arterial spin labeling (ASL) for the assessment and the differential diagnosis of shoulder disorders. Twenty consecutive patients were divided into 4 groups. Group 1 (partial tear or less) had no enhancement at the subacromional region; whereas, group 2 (full thickness tear of rotator cuff) showed significant enhancement due to bursitis. Group 3 (calcific tendinitis) and group 4 (osteoarthritis) also showed well enhancement. ASL perfusion could provide the additional physiological information to the morphological routine shoulder MRI without use of contrast materials, which is valuable for the management of shoulder disorders.}
}
@inproceedings{ISMRM2018_5180,
annote={ISMRM2018_5180},
pages={5180},
file={ISMRM2018_5180.pdf:ISMRM2018_5180.pdf:PDF},
title={Quantitative {MRI} in patients with Greater Trochanteric Pain Syndrome and Asymptomatic Volunteers: an Exploratory Study on T2* and T1 mapping.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5180.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Joseph Rudy Dadour and Guillaume Gilbert and Bernard Leduc and Roger Vadeboncoeur and Jean Rémillard and Nathalie J Bureau},
abstract={Greater Trochanteric Pain Syndrome is a debilitating and highly prevalent disorder in women. Quantitative short-TE MRI sequences might overcome conventional MRI limitations in characterizing and staging gluteus tendinopathy. Ten patients and 10 asymptomatic volunteers were evaluated with hip MRI. Manual segmentations of the hip tendons were done to map T1 and T2* relaxation times. Statistically significant results were found for the T1 values of the lateral gluteus medius tendon and for the T2* values of both parts of the gluteus medius and the gluteus minimus tendons, indicating very promising results.}
}
@inproceedings{ISMRM2018_5181,
annote={ISMRM2018_5181},
pages={5181},
file={ISMRM2018_5181.pdf:ISMRM2018_5181.pdf:PDF},
title={Feasibility of Quantitative Ultrashort Echo Time Magnetization Transfer ({UTE}-{MT}) Modeling Based on Undersampled Acquisitions and {ESPIR}iT Reconstruction},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5181.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yanchun Zhu and Yajun Ma and Jie Yang and Yinghua Zhao and Yaoqin Xie and Eric Y. Chang and Jiang Du},
abstract={Recently the ultrashort echo time magnetization transfer (UTE-MT) technique with two-pool modeling has shown promise as a clinically compatible quantitative technique which is resistant to the magic angle effect. However, the UTE-MT quantitative technique requires multiple acquisitions, which result in suboptimal acquisition times. The purpose of this study is to assess the feasibility of undersampled acquisitions for quantitative UTE-MT modeling applications.}
}
@inproceedings{ISMRM2018_5182,
annote={ISMRM2018_5182},
pages={5182},
file={ISMRM2018_5182.pdf:ISMRM2018_5182.pdf:PDF},
title={Texture features from T2 and T1ρ mapping of meniscus in normal and osteoarthritic knee joints},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5182.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Hon J. Yu and Shoichiro Takao and Shigeo Hagiwara and Hiroshi Yoshioka},
abstract={This study demonstrates a feasibility of texture analysis based on T2 and T1ρ mapping of the meniscus. Some of the investigated texture features showed statistically significant differences for both the medial and lateral meniscus between normal volunteers and patients with osteoarthritic knees. One particular texture feature (contrast) based on T2 was also able to differentiate patients with advanced from early knee osteoarthritis for the lateral meniscus as well. The results in this study demonstrate an alternative analytical approach based on texture features as surrogate variables for the evaluation of meniscus properties using T2 and T1ρ mapping.}
}
@inproceedings{ISMRM2018_5183,
annote={ISMRM2018_5183},
pages={5183},
file={ISMRM2018_5183.pdf:ISMRM2018_5183.pdf:PDF},
title={Comparison of {ZTE} vs {UTE} vs Cones for Ultrashort {TE} {MSK} Imaging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5183.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Michael Carl and Yajun Ma and Jiang Du},
abstract={We compared different center out 3D radial trajectories and assess their advantages and disadvantages for short T2 MSK imaging. We found that while ZTE and Cones may provide some unique capabilities, UTE represents a good compromise between the two.}
}
@inproceedings{ISMRM2018_5184,
annote={ISMRM2018_5184},
pages={5184},
file={ISMRM2018_5184.pdf:ISMRM2018_5184.pdf:PDF},
title={Super-resolution Reconstruction of Knee {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5184.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Pieter Van Dyck and Floris Vanhevel and Eline De Smet and Paul M Parizel and Jan Sijbers and Ben Jeurissen},
abstract={Clinical knee MRI is most commonly performed with 2D-turbo-spin-echo (TSE) sequences in multiple imaging planes. Although these multi-slice sequences provide excellent tissue contrast and high in-plane spatial resolution, they use relatively thick slices, which leads to partial volume effects. This study used super-resolution reconstruction (SRR) to reconstruct isotropic high-resolution knee MR images. Our results indicate that SRR of knee MRI is feasible and compares favorably to direct high-resolution TSE acquisition in terms of image quality and acquisition time. SRR provides an attractive alternative for isotropic 3D-MRI of the knee.}
}
@inproceedings{ISMRM2018_5185,
annote={ISMRM2018_5185},
pages={5185},
file={ISMRM2018_5185.pdf:ISMRM2018_5185.pdf:PDF},
title={Single- and Bi-component Analyses of T2* Relaxation in Knee Tendon and Ligament by Using 3D Ultrashort Echo Time Cones ({UTE} Cones) Magnetic Resonance Imaging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5185.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yinghua Zhao and Yajun Ma and Yanchun Zhu and Shaolin Li and Jiang Du},
abstract={For patellar tendon (PT), anterior cruciate ligament (ACL) and posterior cruciate ligament (PCL) of the knee joint, the in vivo application of the bound and free water mapping techniques is still limited. In this study, we aimed to develop 3D multi-echo fat saturated ultrashort echo time Cones (3D FS-UTE-Cones) imaging protocol for fast volumetric mapping of free and bound water components of whole knee joints in a clinical 3T scanner. The results showed that, for PT, PCL and ACL, the short and long T2* components and their fractions can be characterized by 3D FS-UTE-Cones acquisitions with bi-component T2* analysis, accompanying with superior resolution and short scanning time.}
}
@inproceedings{ISMRM2018_5186,
annote={ISMRM2018_5186},
pages={5186},
file={ISMRM2018_5186.pdf:ISMRM2018_5186.pdf:PDF},
title={Novel {MR} coil hardware and fast 3D imaging sequence in evaluating ankle kinematic instability},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5186.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yuqing Zhao and Zheng Zhang and Xuanhui Wei and Jiayu Zhu and Ling Ji and Nan-Jie Gong and Huishu Yuan},
abstract={A specially designed Ankle \& Foot coil that adapts Achilles Tendon Boot is utilized to multiple angle imaging of ankle kinematic instability. With the 3D fast spin echo sequence with compressed sensing based acceleration technique, multi angle high resolution ankle imaging can be achieved in less than 20 minutes. Images from the volunteer with a history of ankle injuries showing anterior talar translation and rotated internally. The integration of novel coil and compressed sensing based acceleration technique enabled ankle kinematic imaging into clinical routine.}
}
@inproceedings{ISMRM2018_5187,
annote={ISMRM2018_5187},
pages={5187},
file={ISMRM2018_5187.pdf:ISMRM2018_5187.pdf:PDF},
title={Influence of fat saturation on 3D -{UTE} Cones T2* mapping of tendon tissue},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5187.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Paul Baron and Dirk H.J. Poot and Stephan Breda and Edwin H.G. Oei and Juan A. Hernandez-Tamames},
abstract={T2* mapping of tendon tissue is important to assess tissue pathology. Fat contamination however may lead to bias in quantification of T2*. The application of fat saturation (FS) to reduce signal contamination is not straight forward, as this may influence the signal of species with short T2* and broader line-widths. Therefore, the influence of FS on T2* was investigated in tendon tissue. No influence of FS on T2* was observed in ex-vivo tendon tissue. However, in-vivo results suggest fat-contamination was present and FS may be beneficial to reduce T2* quantification bias.}
}
@inproceedings{ISMRM2018_5188,
annote={ISMRM2018_5188},
pages={5188},
file={ISMRM2018_5188.pdf:ISMRM2018_5188.pdf:PDF},
title={Application of Intravoxel incoherent motion diffusion imaging in evaluation of tendon perfusion},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5188.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Michael Liu and Patrick Quarterman and Sachin Jambawalikar and Tony Wong},
abstract={Altered perfusion may be a marker of tendon damage. Measurable perfusion characteristics using non contrast techniques such as Intravoxel Incoherent Motion Diffusion Weighted imaging may be a useful technique for assessing perfusion characteristics of tendon.}
}
@inproceedings{ISMRM2018_5189,
annote={ISMRM2018_5189},
pages={5189},
file={ISMRM2018_5189.pdf:ISMRM2018_5189.pdf:PDF},
title={Imaging low grade inflammation in post-traumatic osteoarthritis},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5189.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Amparo Ruiz and Alejandra Duarte and Mark Milne and Zahid Dewan and Len Luyt and José G Raya},
abstract={Chronic inflammation has been identified as a major driver of joint degradation after injury. MRI is very limited to assess chronic inflammation with high specificity. Here we propose a novel contrast agent that targets the interaction of hyaluronan with RAMM cell receptors that represent an important signaling pathway for chronic inflammation. We validated the contrast agent with optical imaging and showed its value as an MRI contrast agent.}
}
@inproceedings{ISMRM2018_5190,
annote={ISMRM2018_5190},
pages={5190},
file={ISMRM2018_5190.pdf:ISMRM2018_5190.pdf:PDF},
title={New Tissue Saturation Method for the Detection of Therapeutic Cells in a Knee Joint},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5190.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Djaudat Idiyatullin and Michael Garwood and Sergey Magnitsky},
abstract={Synapsis. Mesenchymal Stem Cells (MSCs) have a high potential for a treatment of bone diseases. We develop new acquisition protocol for the detection of therapeutic cells in knee joints. Labeling MSCs with iron oxide particles not only reduce T2* but also induce the resonance frequency shift of labeled cells. This shift enabled us to implement tissue saturation scheme and detect distinct hyperintense signal from grafted cells. New protocol allowed us to detect and quantify therapeutic cells for six days after implantation which was not possible before. Proposed protocol opens new opportunities for in vivo monitoring of cell therapy of bone disorders.}
}
@inproceedings{ISMRM2018_5191,
annote={ISMRM2018_5191},
pages={5191},
file={ISMRM2018_5191.pdf:ISMRM2018_5191.pdf:PDF},
title={High resolution 1 mm isotropic semi continuous wave gag{CEST} of articular cartilage using parallel transmit at 7T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5191.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Sander Brinkhof and Vitaliy Khlebnikov and Fredy Visser and Hans Hoogduin},
abstract={The purpose of this work was to implement gagCEST imaging in articular cartilage at 7T using a parallel transmit setup. Two alternating sets of four transmit channels were used in quadrature mode to create a semi continuous excitation pulse. Using this setup, an isotropic 1 mm spatial resolution could be achieved with a low coefficient of variation of 1.05\% (@0.9ppm) within an acquisition time of 5 minutes. To the best of our knowledge, this is the highest gagCEST resolution shown so far in literature.}
}
@inproceedings{ISMRM2018_5192,
annote={ISMRM2018_5192},
pages={5192},
file={ISMRM2018_5192.pdf:ISMRM2018_5192.pdf:PDF},
title={Synthetic{TSE}: Accelerated multicontrast spin-echo knee {MRI} using a combination of Bloch-simulation models, compressed sensing and simultaneous multislice acquisition},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5192.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Akio Yoshimoto and Noam Ben-Eliezer and Mary Bruno and Steven H Baete and Michael Recht and Ricardo Otazo},
abstract={Clinical knee MRI examinations usually consist of a series of 2D acquisitions with different contrasts and orientations. In this work, we propose to simplify and shorten the examination by performing multi-contrast imaging using a single acquisition by directly reconstructing parametric maps (PD and T
2) and then synthesizing the contrasts of clinical interest (PD-weighted and T
2-weighted with and without fat suppression). The proposed SyntheticTSE method uses a Bloch-simulation signal model for parametric mapping and a combination of compressed sensing and simultaneous multislice acceleration. Initial feasibility is demonstrated using retrospective undersampling of multi-spin-echo knee dataset}
}
@inproceedings{ISMRM2018_5193,
annote={ISMRM2018_5193},
pages={5193},
file={ISMRM2018_5193.pdf:ISMRM2018_5193.pdf:PDF},
title={Effects of Reduced Dead Times on the {SNR} of Tissue with Short T2* values},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5193.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Agazi Samuel Tesfai and Johannes Fischer and Ali Caglar Özen and Ute Ludwig and Michael Bock},
abstract={MRI of tissues with short T2* can be realized with ultra-short echo time (UTE) sequences. The effect of lowering TE on relative SNR is calculated and evaluated. The limiting factor for dead time and, consequently, low TE is determined for hardware components of clinical MR system and compared to benchmark results.}
}
@inproceedings{ISMRM2018_5194,
annote={ISMRM2018_5194},
pages={5194},
file={ISMRM2018_5194.pdf:ISMRM2018_5194.pdf:PDF},
title={3D nerve-sheath signal increased with inked rest-tissue rapid acquisition of relaxation enhancement imaging(3D {SHINKEI}) in traumatic brachial plexopathy},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5194.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Shanshan Wang and Guangbin Wang and Weibo Chen},
abstract={3D SHINKEI MRN with high spatial resolution ,is an extremely useful modality to image the traumatized brachial plexus and helps to accurately image the complete brachial plexus and localize as well as describe the lesions from the root still the terminal nerves.}
}
@inproceedings{ISMRM2018_5195,
annote={ISMRM2018_5195},
pages={5195},
file={ISMRM2018_5195.pdf:ISMRM2018_5195.pdf:PDF},
title={4D {MSK} {MRI}: Feasibility of Continuous and Pseudo Real-Time Imaging in the Shoulder and the Wrist},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5195.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Mitsue Miyazaki and Won C Bae and Cheng Ouyang and Dawn Berkeley and Sheronda Statum and Christine B Chung},
abstract={For dynamic evaluation of musculoskeletal joints including the shoulder and the wrist, continuous and pseudo real-time techniques were developed in 4D (3D acquisition and time) using single shot FSE (SSFSE). Effective echo time (TEeff) of SSFSE was optimized for the contrast at each joint. Advantages of 4D over existing 2D techniques are volume acquisition with thinner slices, crucial in cases of target structures moving out of a single 2D imaging slice. Both continuous and pseudo real-time images permitted depiction of joint movements with good contrast; however, pseudo real-time gives slightly sharper images as compared to continuous real-time images.}
}
@inproceedings{ISMRM2018_5196,
annote={ISMRM2018_5196},
pages={5196},
file={ISMRM2018_5196.pdf:ISMRM2018_5196.pdf:PDF},
title={Comparison of gag{CEST} Effects in Phantoms and Bovine Musculoskeletal Specimens Using 2D Single-Shot Fast Spin Echo and 3D Ultrashort Time-to-Echo at 3-Tesla},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5196.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Mitsue Miyazaki and Cheng Ouyang and Nirusha Abeydeera and Dawn Berkeley and Reni Biswas and Sheronda Statum and Won C Bae and Christine B Chung},
abstract={3D UTE and 2D single-shot fast spin-echo (SSFSE) gagCEST techniques were used to image varying concentrations of chondroitin sulfate (CS) in long or short T1 solutions. Echo time (TE) in SSFSE and UTE ranged from 10-60 ms and 0.1-8 ms, respectively. Effect of TE on asymmetric magnetization transfer ratio (MTR
asym) was examined around 1.0 and 3.5 ppm. For long T1 saline phantom, we found a general increase in MTR
asym with concentration, with similar slopes over different TEs, for either technique. For short T1 MnCl2 doped phantom, while UTE could acquire gagCEST signal unlike SSFSE, no consistent trends were found.}
}
@inproceedings{ISMRM2018_5197,
annote={ISMRM2018_5197},
pages={5197},
file={ISMRM2018_5197.pdf:ISMRM2018_5197.pdf:PDF},
title={{SNR} Optimization of Simultaneous Multi-Slice Accelerated {TSE} Sequences for Diabetic Foot Imaging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5197.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yauheni Rudzevich and Kenneth Buckwalter and Chen Lin and Dingxin Wang},
abstract={To optimize Simultaneous Multi-Slice (SMS) accelerated TSE sequences for ultra-fast imaging of patients with diabetic neuropathy, a phantom study was performed to determine the optimal Field of View Shift (FOVS) which is a key parameter for SMS, but depend on other imaging parameters and coil configuration. SNR maps for different FOVS were measured using a subtraction method combined with shifting ROI. The optimal selections of FOVS based on quantitative SNR measurement are in good agreement with the selections derived from visual evaluation of clinical images by radiologists. Such agreement provides additional confidence.}
}
@inproceedings{ISMRM2018_5198,
annote={ISMRM2018_5198},
pages={5198},
file={ISMRM2018_5198.pdf:ISMRM2018_5198.pdf:PDF},
title={Fully-Automated Segmentation of Knee Joint Anatomy using Deep Convolutional Neural Network Approach},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5198.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Fang Liu and Zhaoye Zhou and Richard Kijowski},
abstract={A new fully-automated approach was proposed using a deep convolutional encoder-decoder (CED) network combined with 3D fully-connected conditional random field (CRF) and 3D simplex modeling for performing efficient and accurate multi-class musculoskeletal tissue segmentation from MR images. The deep learning-based segmentation method could be used to create 3D rendered models of all knee joint structures including cartilage, bone, tendon, meniscus, muscle, infrapatellar fat pad and joint effusion and Baker’s cyst which may be sources of pain in patients with knee osteoarthritis. The results of our study serve as a first step to provide quantitative MR measures of musculoskeletal tissue degeneration in a highly time efficient manner which would be practical for use in large population-based osteoarthritis research studies.}
}
@inproceedings{ISMRM2018_5199,
annote={ISMRM2018_5199},
pages={5199},
file={ISMRM2018_5199.pdf:ISMRM2018_5199.pdf:PDF},
title={Ultrashort Echo Time-{MRI} of proximal femoral cortical bone in patients with osteoporosis},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5199.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Dimitri MARTEL and Mary BRUNO and H.Michael BELMONT and Amit SAXENA and Gabrielle TURYAN and Stephen HONIG and Ravinder R. REGATTE and Gregory CHANG},
abstract={Ultra-short echo time MRI (uTE-MRI) allows exploration of the role of cortical bone properties in osteoporosis. OP can be primary or can also be induced by drugs such as glucocorticoids (glucocorticoid-induced osteoporosis, GIO).No previous studies have assessed cortical porosity in GIO patients compared to OP patients.Our aim was to perform uTE-MRI of cortical bone of the proximal femur (a common site of fracture) in GIO patients and compare the results to those of OP patients using a bi-exponential fitting procedure of uTE images.
}
}
@inproceedings{ISMRM2018_5200,
annote={ISMRM2018_5200},
pages={5200},
file={ISMRM2018_5200.pdf:ISMRM2018_5200.pdf:PDF},
title={The uncinate fasciculus: hemispheric asymmetries of {DTI} metrics and curvature mapping},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5200.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Lia Talozzi and Claudia Testa and Stefania Evangelisti and Lorenzo Cirignotta and Claudio Bianchini and Micaela Mitolo and Paola Fantazzini and Caterina Tonon and David Neil Manners and Raffaele Lodi},
abstract={We reconstructed the uncinate fasciculus bilaterally by probabilistic tractography in a group of 29 healthy subjects, in order to quantitatively investigating hemispheric asymmetries. We evaluated tract volume and DTI metrics. Our tract Laplacian parameterization successfully described curving bundles and allowed the calculation of along-tract measures and curvature mapping. Group variability maps showed a more dorsal route in the left hemisphere, towards the lateral fronto-orbital cortex. We also found a higher fractional anisotropy on the right compared to the left and different tract curvature. These asymmetries could be associated to specific tract functions as semantic and emotional processing, selectively affected in pathologies.}
}
@inproceedings{ISMRM2018_5201,
annote={ISMRM2018_5201},
pages={5201},
file={ISMRM2018_5201.pdf:ISMRM2018_5201.pdf:PDF},
title={Ischemic optic neuropathy: Using Track-Weighted Imaging to detect changes in the neuroretina},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5201.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Arnaud Attyé and Felix Renard and Clement Jean and Laurent Lamalle and Alexandre Krainik},
abstract={Track-Weighted Imaging was recently introduced as a qualitative tractography-based method with super-resolution properties and high anatomical contrast. We report the use of this method to explore the human retina. In healthy volunteers, we showed that reconstructions of neuroretinal fascicles were influenced by diffusion acquisition parameters, ocular laterality and ocular dominance. We have raised the hypothesis that patients with anterior ischaemic optic neuropathy, a disease that leads to degeneration of neuroretinal cells, could present with specific neuroretinal fascicle injuries. We demonstrated that presence of the temporal fascicle in the affected eye provides an objective outcome radiological sign correlated with visual recovery.}
}
@inproceedings{ISMRM2018_5202,
annote={ISMRM2018_5202},
pages={5202},
file={ISMRM2018_5202.pdf:ISMRM2018_5202.pdf:PDF},
title={Tractography-Based Atlas of the Healthy Cortico-Spinal Tract},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5202.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Aymeric Stamm and Alessandro Zito and Valeria Callioni and Ilaria Sartori and Luca Torriani and Simone Vantini},
abstract={The corticospinal tract is a critical white matter pathway as it connects the primary motor cortex to the spinal cord and handles voluntary motion. Atlases of major brain connections do exist, but, surprisingly, atlases that depict the actual localisation of a specific pathway are missing. In this work, we propose a comprehensive statistical methodology for generating an atlas of the healthy CST. This should help designing efficient statistical tests for detecting damaged tissue along the CST and consequently improving patient outcome in a number of brain pathologies (tumors, strokes, Parkinson and related disorders, etc.).}
}
@inproceedings{ISMRM2018_5203,
annote={ISMRM2018_5203},
pages={5203},
file={ISMRM2018_5203.pdf:ISMRM2018_5203.pdf:PDF},
title={Bootstrapping Fibre Orientation Distributions: Accuracy advantages and other benefits of estimating shape uncertainty},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5203.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Marina Rakic and Robert Dallyn and Flavio Dell'Acqua},
abstract={Inherently low signal-to-noise ratio in diffusion-MRI results in high uncertainty in the estimated underlying fibre orientation distributions. True bootstrapping and model- based residual bootstrapping approaches have been proposed to estimate the uncertainty in the estimated peak directions. Here we compare the two methods using simulations and observe that more information can be extracted by looking at the variation in the entire shape of the FOD, as opposed to just the peak direction. Results also suggest that, in this case, residual bootstrapping might not provide a representative estimation of directional uncertainty due to non-negligible model bias.}
}
@inproceedings{ISMRM2018_5204,
annote={ISMRM2018_5204},
pages={5204},
file={ISMRM2018_5204.pdf:ISMRM2018_5204.pdf:PDF},
title={Biases in classical structural parcellation},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5204.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Michael Hejselbak Jensen and Henrik Thomsen and Sune Darkner and Matthew Liptrot and Niklas Kasenburg and Karl-Anton Dorph-Petersen and Aasa Feragen},
abstract={The classical structural parcellation algorithm by Behrens et al
1 remains widely used in clinical research, largely thanks to its simplicity and availability in standard MRI processing software. However, its construction and dependency on tractography leads to several biases that can severely affect the conclusions drawn from it, but which are not well known. We illustrate these biases via the original thalamus parcellation experiment on Human Connectome Project (HCP) data
3. Based on our experiments, we outline open problems for future structural parcellation algorithms and possible directions for overcoming them.}
}
@inproceedings{ISMRM2018_5205,
annote={ISMRM2018_5205},
pages={5205},
file={ISMRM2018_5205.pdf:ISMRM2018_5205.pdf:PDF},
title={Exploring peritumoral neural tracts by using Neurite Orientation Dispersion and Density Imaging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5205.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Shin Tai Chong and Hung-Wen Kao and Chien-Yuan Eddy Lin and Chiao-Chi Chen and Chun-Yi Zac Lo and Ching-Po Lin and Chen Chang},
abstract={We hypothesized that the Neurite Orientation Dispersion and Density Imaging (NODDI)-based tractography could improve the reconstruction of the fiber tracts that by tracking through regions of peritumoral edema. In visual comparison with diffusion tensor imaging (DTI), this model provided similar performance in healthy side and better performance in the corticospinal tract (CST) of the affected side. This technique may help neurosurgeons to define an optimal safe margin for total resection.}
}
@inproceedings{ISMRM2018_5206,
annote={ISMRM2018_5206},
pages={5206},
file={ISMRM2018_5206.pdf:ISMRM2018_5206.pdf:PDF},
title={The impact of structure tensor informed fibre tractography ({STIFT}) on structural connectivity},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5206.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Kwok-Shing Chan and David G. Norris and José P. Marques},
abstract={Structure tensor informed fibre tractography(STIFT) incorporating white matter morphology from gradient echo data to diffusion data is beneficial in the presence of kissing and highly curved fibres. However, previous demonstrations of STIFT provide only qualitative results and its performance beyond the initial targets (optic radiation and cingulum) is still unknown. This study investigated the quantitative effects of STIFT through structural connectivity comparison between diffusion tractography and STIFT. We found that there is no change of connectivity with STIFT in major structural connections.}
}
@inproceedings{ISMRM2018_5207,
annote={ISMRM2018_5207},
pages={5207},
file={ISMRM2018_5207.pdf:ISMRM2018_5207.pdf:PDF},
title={{DTI}-based Network Analysis of {APP}/{PS}1 Mouse Brains with Age and Sex},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5207.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Samuel Colles Grant and David C Hike and Abdol Aziz Ould Ismail and Victor Wong and Scott Boebinger and Tara Palin},
abstract={This study utilizes DTI and graph theory as a novel way for identifying early pathology and connectivity changes related to Alzheimer’s Disease. As a function of phenotype, age and sex, DTI studies were performed on APP/PS1 mouse brains and age-matched wild type controls at 11.75 T. Current data shows a drop in FA and a decrease in connectivity in the temporal region of the brain. High resolution 3D images acquired at 21.1 T display the presence of amyloid plaques, which temporally correlate with the progression of structural connectivity alterations in this transgenic preclinical model.}
}
@inproceedings{ISMRM2018_5208,
annote={ISMRM2018_5208},
pages={5208},
file={ISMRM2018_5208.pdf:ISMRM2018_5208.pdf:PDF},
title={The unresolved problem of synaptic connectivity in the context of the cerebro-cerebellar loop},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5208.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Fulvia Palesi and Fernando Calamante and Giovanni Savini and Egidio D'Angelo and Claudia Angela Michela Gandini Wheeler-Kingshott},
abstract={Recently advanced tractography has been used for assessing the feasibility of characterizing cerebro-cerebellar tracts, acknowledging the issue of how tractography deals with polysynaptic connectivity in particular through the thalamus. In this work, four different synaptic connectivity configurations at thalamic level were hypothesized and each one of them was reconstructed using high-quality HCP data. Our findings revealed the key role of thalamic connectivity for characterizing the cerebro-cerebellar connections. We can hypothesize that the relation between streamlines entering/outing the thalamic synapses is multiplicative and our findings using polysynaptc thalamic tracts support the fact that cognitive/associative areas are the mainly involved in the cerebro-cerebellar connections.}
}
@inproceedings{ISMRM2018_5209,
annote={ISMRM2018_5209},
pages={5209},
file={ISMRM2018_5209.pdf:ISMRM2018_5209.pdf:PDF},
title={Improved fibre tracking with optimized diffusion-weighted single-refocused spin echo {EPI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5209.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Manoj Shrestha and Pavel Hok and Ulrike Nöth and Bianca Lienerth and Ralf Deichmann},
abstract={This study investigates the suitability of data acquired with an optimized diffusion-weighted (DW) single-refocused spin-echo EPI sequence for fibre tracking. The proposed scheme uses dummy scans of 1.5s duration prior to the acquisition of each multi-slice data volume, thus driving eddy-currents into a steady-state, thus allowing to use an optimized parameter setting of the eddy-current correction tool “EDDY”. Results show that the proposed sequence yields better fibre tracking results than conventional DW sequences with a more precise estimation of the subsidiary fibre orientations, showing additional connections to the lateral frontal, parietal and temporal cortices and to the thalamus.}
}
@inproceedings{ISMRM2018_5210,
annote={ISMRM2018_5210},
pages={5210},
file={ISMRM2018_5210.pdf:ISMRM2018_5210.pdf:PDF},
title={Are Brain Networks Reproducible across Sites?},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5210.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Abdol Aziz Ould Ismail and Drew Parker and Sriram Moparthy and Birkan Tunç and Ragini Verma},
abstract={The field of connectomics has introduced new computational tools to the system neuroscience domain, facilitating novel investigations into the mechanisms of the human brain. While methodological advancements in connectomics have found numerous applications with exciting interpretations, a systematic analysis on the reliability and reproducibility of the results and inferences drawn from the findings is still missing. We aim to fill this gap by studying the reproducibility of connectomics findings on diffusion data that has been collected at different sites with varying acquisition protocols. Structural network properties at local, meso and global scales were investigated to determine what is different and what is preserved in the presence of site related variation. Our comprehensive investigation revealed that despite significant differences between local and global properties, the topological features were mostly preserved.}
}
@inproceedings{ISMRM2018_5211,
annote={ISMRM2018_5211},
pages={5211},
file={ISMRM2018_5211.pdf:ISMRM2018_5211.pdf:PDF},
title={Personalized Lesion Profiling in Multiple Sclerosis},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5211.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Sidong Liu and Alexander Klistorner and Chenyu Wang and Yang Gao and Brittany Gilchrist and Yang Song and Yuyi You and Junen Yao and Weidong Cai and Michael Barnett},
abstract={The pathology of multiple sclerosis (MS) lesions is highly subject-specific, therefore personalized lesion analysis is important in assessing the degree of disease-related brain damage and the patient’s response to therapy. Separating and comparing lesional and non-lesional tissue provides an “internal control” and, therefore, increased precision of measurement of the degree of lesional damage in the brain. Here we present a novel and fully automatic method to create a personalized lesion profile of the subject based on DTI tractography, which can be used to assess whole brain lesional damage. This technique can be applied to measure microstructural change using any MRI modality and may have high translational impact in clinical trials and neurological research.}
}
@inproceedings{ISMRM2018_5212,
annote={ISMRM2018_5212},
pages={5212},
file={ISMRM2018_5212.pdf:ISMRM2018_5212.pdf:PDF},
title={Reproducibility of Human Diffusion Connectomes Generated from Different Atlases: A Multicenter Study},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5212.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Qiqi Tong and Hongjian He and Peipeng Liang and Ting Gong and Tianyi Qian and Yi Sun and Qiuping Ding and Chen Li and Kuncheng Li and Jianhui Zhong},
abstract={In a multicenter study, high reproducibility among centers is essential. However, the construction of diffusion connectomes requires multiple complex steps. Errors may be easily hidden in the connectome matrix and possible deteriorate the intrinsic neural network analysis. The registration and parcellation based on the brain template are the final steps and are vital to the connectome matrix. A different anatomical and functional image-based atlas may produce variable reproducibility in diffusion connectome matrices. In this work, seven frequently used atlases were compared to test the reproducibility of different templates.}
}
@inproceedings{ISMRM2018_5213,
annote={ISMRM2018_5213},
pages={5213},
file={ISMRM2018_5213.pdf:ISMRM2018_5213.pdf:PDF},
title={{AFQ}-Browser: Supporting reproducible human neuroscience research through browser-based visualization tools},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5213.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jason Yeatman and Adam Richie-Halford and Josh Kenyon Smith and Anisha Keshavan and Ariel Rokem},
abstract={MRI research faces various challenges with regards to reproducibility: scientists are generally aware that data sharing is an important component of reproducible research, but it is not always clear how to share data in a manner that allows other researchers to understand and reproduce published findings. Here we describe AFQ-Browser, a software tool that builds an interactive website as a companion to a diffusion MRI study and leverages web-visualization technologies to create linked views between different aspects of a diffusion MRI dataset (anatomy, diffusion metrics, subject metadata). This facilitates exploratory data analysis, fueling new scientific discoveries based on previously published datasets.}
}
@inproceedings{ISMRM2018_5214,
annote={ISMRM2018_5214},
pages={5214},
file={ISMRM2018_5214.pdf:ISMRM2018_5214.pdf:PDF},
title={Adaptive linear discriminant analysis for complex networks to study extreme prematurity and intrauterine growth restriction effects at school age},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5214.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Serafeim Loukas and Djalel Eddine Meskaldji and Elda Fischi Gomez and Lana Vasung and Dimitri Van De Ville and Petra Susan Huppi},
abstract={In this study, we combined complex network theory with machine learning in order to grasp potential biomarkers of brain development. The data consists of brain connectomes (brain connectivity matrices) of 53 children aged six years old. For each subject, we estimated brain network-based measures at four different levels: connection, node, module and global levels. Then we applied linear discriminant analysis and support vector machine in order to extract features and we compared their performances. We showed that node and module levels are the best choices to extract relevant and interpretable biomarkers in order to distinguish between different brain development conditions.}
}
@inproceedings{ISMRM2018_5215,
annote={ISMRM2018_5215},
pages={5215},
file={ISMRM2018_5215.pdf:ISMRM2018_5215.pdf:PDF},
title={Advances in structural and functional connectivity visualization using the Fibernavigator},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5215.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Maxime Chamberland and Maxime Descoteaux and Derek K. Jones},
abstract={Scientific data visualization is constantly challenged by the continuously growing diffusion MRI (dMRI) field. Exploring and interacting with high-dimensional datasets is central to every analysis pipeline, allowing us to better understand the behavior of a certain tracking algorithm, for example. In this abstract, we present a brief overview of the recent advances in data analysis \& visualization available inside the Fibernavigator package.}
}
@inproceedings{ISMRM2018_5216,
annote={ISMRM2018_5216},
pages={5216},
file={ISMRM2018_5216.pdf:ISMRM2018_5216.pdf:PDF},
title={Enhancing bundle topology for tractography visualization using silhouette rendering},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5216.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Maxime Chamberland and Derek K. Jones},
abstract={Global illumination rendering techniques are often considered the gold standard for displaying 3D structures. They are however computationally expensive and most neuroimaging software packages do not support such advanced methods. Here, we applied cartoon-like shading to tractography-derived bundles to enhance visualization of their topological features. Combined with glass-brain rendering, we believe that this non-realistic rendering technique can help both new comers to the field and experienced scientists to better perceive shape specific features of brain bundles, enhancing both neuroanatomical understanding and neurosurgical planning.}
}
@inproceedings{ISMRM2018_5217,
annote={ISMRM2018_5217},
pages={5217},
file={ISMRM2018_5217.pdf:ISMRM2018_5217.pdf:PDF},
title={Generation of a muscle fibre orientation atlas of the in vivo tongue},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5217.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Luuk Voskuilen and Ludi E. Smeele and Alfons J.M. Balm and Ferdinand van der Heijden and Gustav J. Strijkers and Aart J. Nederveen},
abstract={While diffusion tensor imaging based atlases in the brain are common, no muscle fibre atlases for the tongue have been created. An unbiased atlas was generated from ten healthy volunteers, by iteratively registering fibre orientation distributions calculated via constrained spherical deconvolution to a template. The atlas shows good reproducibility and better performance than an image intensity based atlas. Various tongue muscles can be detected in tractography of the atlas. This atlas may facilitate automatic segmentation of tongue muscles after tumour resection to evaluate impaired tongue function.}
}
@inproceedings{ISMRM2018_5218,
annote={ISMRM2018_5218},
pages={5218},
file={ISMRM2018_5218.pdf:ISMRM2018_5218.pdf:PDF},
title={Functional- and Structural-Connectivity Connectome Fingerprints Correlate With Cognitive Behavior Traits in {HCP} Datasets},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5218.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ying-Chia Lin and Steven H. Baete and Xiuyuan Wang and Fernando E. Boada},
abstract={Connectome analysis of the human brains structural and functional architecture provides a unique opportunity to understand the organization of brain networks. Recently, connectome fingerprinting using brain functional connectivity profiles as the unique traits was able to identify individuals from the group in the Human Connectome Project (HCP) datasets. In HCP s900 datasets, we extend connectome fingerprinting from functional to structural connectivity, identifying multiple relationships between behavioral traits and brain connectivity.}
}
@inproceedings{ISMRM2018_5219,
annote={ISMRM2018_5219},
pages={5219},
file={ISMRM2018_5219.pdf:ISMRM2018_5219.pdf:PDF},
title={The Benefits Of Cognitive Training Depend On The Wiring Of The Brain},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5219.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Karen Caeyenberghs and Claudia Metzler-Baddeley and Peter Wilson and Derek K Jones},
abstract={There is strong evidence that task-specific training leads to changes in brain structure, as assessed using MRI-based techniques that probe microstructure or morphology. In the present study, we want to understand the specific mechanisms of action of task-specific training and identify other critical ingredients. Here, we used a well-established working memory training program and state-of-the art neuroimaging methods in 40 healthy adults. Further research on dose, timing and duration of training is necessary to generalize the training protocols to the field of structural neuroplasticity.}
}
@inproceedings{ISMRM2018_5220,
annote={ISMRM2018_5220},
pages={5220},
file={ISMRM2018_5220.pdf:ISMRM2018_5220.pdf:PDF},
title={Automated fibre tractography of the optic radiation for epilepsy surgery planning},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5220.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Sjoerd B Vos and Matteo Mancini and Vejay Vakharia and Rachel Sparks and Mei Iok Chiang and M Jorge Cardoso and John S Duncan and Gavin P Winston and Sebastien Ourselin},
abstract={Fibre tractography of the optic radiation can be helpful in epilepsy surgery, but its widespread clinical use is hampered by the need for time-consuming expert manual ROI delineations and interrater variability. Our automated approach using anatomically constrained geodesic shape-based averaging is evaluated on two diffusion MRI datasets from different scanners. Automatically generated tracts are within the interrater agreement of two expert raters when evaluating for distance between temporal pole and Meyer’s loop for both datasets, with a tendency towards a more inclusive Meyer’s loop in the automated method.}
}
@inproceedings{ISMRM2018_5221,
annote={ISMRM2018_5221},
pages={5221},
file={ISMRM2018_5221.pdf:ISMRM2018_5221.pdf:PDF},
title={Decomposition of brain structural connectivity using Independent component analysis},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5221.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Farzaneh Keyvanfard and Abbas Nasiraei Moghaddam and Alessandra Griffa and Patric Hagmann},
abstract={Diffusion imaging provides the capability of investigating brain white matter non-invasively. There is an increasing interest in studying whole brain structural connectivity (SC) as a complex network, but examining multiple structural sub-networks has yet to be investigated. In this study we have proposed a specific pipeline to decompose whole brain structural connectivity into different sub-networks using Independent Component Analysis (ICA). Obtaining two structural gender related sub-networks in line with previous findings confirms the feasibility of the approach.}
}
@inproceedings{ISMRM2018_5222,
annote={ISMRM2018_5222},
pages={5222},
file={ISMRM2018_5222.pdf:ISMRM2018_5222.pdf:PDF},
title={Reducing Tractogram Endpoint Biases with Surface-Enhanced Tractography},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5222.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Etienne St-Onge and Maxime Descoteaux},
abstract={In this work, we highlight the importance and advantages of integrating cortical surfaces with dMRI tractography. Doing so facilitates the integration of gray matter (GM) features in white matter (WM) connectivity analysis. Extending streamlines to cortical meshes allows the study of WM structural features from tractography along the cortex. This combined approach also enables the measurement of streamline connections cortical coverage and density bias with different tractography algorithms.
}
}
@inproceedings{ISMRM2018_5223,
annote={ISMRM2018_5223},
pages={5223},
file={ISMRM2018_5223.pdf:ISMRM2018_5223.pdf:PDF},
title={Accurate fibre dispersions from varying the b-tensor shape},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5223.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Michiel Cottaar and Filip Szczepankiewicz and Matteo Bastiani and Stamatios N. Sotiropoulos and Markus Nilsson and Saad Jbabdi},
abstract={Accurate measures of fibre dispersion might improve tractography through voxels with bending and/or fanning configurations and also provide more accurate tissue microstructure indices. When estimated from regular diffusion MRI, however, the accuracy of the dispersion estimate depends on the accuracy of the underlying microstructural model. In this work, we find that encoding water diffusion using multiple shapes of the b-tensor leads to an accurate measurement of fibre dispersion within a single b-shell. We show that this holds for complicated sub-voxel geometries using both simulations and in vivo data.}
}
@inproceedings{ISMRM2018_5224,
annote={ISMRM2018_5224},
pages={5224},
file={ISMRM2018_5224.pdf:ISMRM2018_5224.pdf:PDF},
title={Intra-axonal Fractional Anisotropy from Fiber Ball Imaging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5224.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Hunter Moss and Emilie T. McKinnon and Andreana Benitez and Dorothea D. Jenkins and G. Russel Glenn and Jens H. Jensen and Joseph A. Helpern},
abstract={Using fiber ball imaging (FBI), we isolate the intra-axonal compartment of the white matter with strong diffusion weighting in order to suppress the extra-axonal water fraction and then calculate its associated fractional anisotropy (FA). We call this parameter the fractional anisotropy axonal (FAA) in contrast to the conventional FA and we compare these two measures in three subjects: a healthy young adult, a cognitively intact older adult with severe white matter abnormalities and a neonate with acute hypoxic ischemic injury. Our results indicate that FAA reveals diffusion anisotropy that is not apparent using the conventional FA.}
}
@inproceedings{ISMRM2018_5225,
annote={ISMRM2018_5225},
pages={5225},
file={ISMRM2018_5225.pdf:ISMRM2018_5225.pdf:PDF},
title={Deep Learning Captures More Accurate Diffusion Fiber Orientations Distributions than Constrained Spherical Deconvolution},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5225.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Vishwesh Nath and Kurt G Schilling and Prasanna Parvathaneni and Allison E Hainline and Colin B Hansen and Camilo Bermudez and Andrew J Plassard and Justin A Blaber and Vaibhav Janve and Yurui Gao and Iwona Stepniewska and Adam W Anderson and Bennett A Landman},
abstract={Confocal histology provides an opportunity to establish intra-voxel fiber orientation distributions that can be used to quantitatively assess the biological relevance of diffusion-weighted MRI models, e.g., constrained spherical deconvolution (CSD). Here, we apply deep learning to investigate the potential of single shell diffusion-weighted MRI to explain histologically observed fiber orientation distributions (FOD) and compare the derived deep learning model with a leading CSD approach. This study (1) demonstrates that there exists additional information in the diffusion signal that is not currently exploited by CSD and (2) provides an illustrative data-driven model that makes use of this information.}
}
@inproceedings{ISMRM2018_5226,
annote={ISMRM2018_5226},
pages={5226},
file={ISMRM2018_5226.pdf:ISMRM2018_5226.pdf:PDF},
title={Influence of the size and curvedness of neural projections on the orientationally averaged diffusion {MR} signal},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5226.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Evren Özarslan and Cem Yolcu and Magnus Herberthson and Hans Knutsson and Carl-Fredrik Westin},
abstract={We studied the orientationally averaged diffusion weighted MR signal for diffusion along general curves at all three temporal regimes of the traditional pulsed field gradient measurements. We found that long fibers as well as short fibers that are straight could yield the $q^{-1}$ decay. The absence of such a decay suggests fibers that are short and curvy. We note that the true asymptotic behavior of the signal decay is characterized by the Debye-Porod law, which suggests $\bar{E}(q)\propto q^{-4}$ at very large $q$-values. This study is expected to provide insights for interpreting the diffusion-weighted images of the central nervous system.}
}
@inproceedings{ISMRM2018_5227,
annote={ISMRM2018_5227},
pages={5227},
file={ISMRM2018_5227.pdf:ISMRM2018_5227.pdf:PDF},
title={Estimation of the brain microstructure in the presence of crossing fascicles from a dictionary of Monte Carlo signals},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5227.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Gaëtan Rensonnet and Benoit Scherrer and Gabriel Girard and Jonathan Rafael-Patino and Simon K Warfield and Benoit Macq and Jean-Philippe Thiran and Maxime Taquet},
abstract={We estimate microstructural features of crossing fascicles using Monte Carlo simulations to represent the diffusion attenuation of each fascicle. The measured diffusion-weighted MRI signal is reconstructed as a sparse weighted sum of pre-computed signals and microstructural properties are estimated from the selected fascicle configurations. The consistent results obtained on various synthetic phantoms as well as on in vivo brain data suggest the potential of our method for the quantitative estimation of microstructural features in fascicle crossings.}
}
@inproceedings{ISMRM2018_5228,
annote={ISMRM2018_5228},
pages={5228},
file={ISMRM2018_5228.pdf:ISMRM2018_5228.pdf:PDF},
title={Advanced quantification of dispersion and directionality in three-dimensional electron microscopy images and diffusion {MR} imaging of injured rat brain},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5228.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Raimo A. Salo and Ilya Belevich and Eppu Manninen and Eija Jokitalo and Olli Gröhn and Alejandra Sierra},
abstract={The relationship between orientation distribution functions (ODFs) from advanced dMRI and the real tissue microstructure is under active research. We utilized three-dimensional (3D) serial block-face scanning electron microscopy in the corpus callosum and cingulum and implemented 3D structure tensor (ST) analysis to produce ODFs comparable to dMRI ODFs from the same locations. The ODFs were parametrized using Watson distribution. Our results showed a clear correspondence in orientation estimates, but dispersion estimates were not as clearly correlated. ST analysis combined with 3D SBEM has great potential to unveil the complexity of the underlying microstructure in biological tissues.}
}
@inproceedings{ISMRM2018_5229,
annote={ISMRM2018_5229},
pages={5229},
file={ISMRM2018_5229.pdf:ISMRM2018_5229.pdf:PDF},
title={Sensing Von Economo Neurons in the Insula with Multi-shell Diffusion {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5229.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Demian Wassermann and Van-Dang Nguyen and Guillermo Gallardo-Diez and Jing-Rebecca Li and Weidong Cai and Vinod Menon},
abstract={Sensing microstructural characteristics of human brain tissue with clinical scanners has been an area of heated debate in the diffusion MRI (dMRI) community . In this work we propose that diffusion MRI on clinical scanners is sensitive to the presence of Von Economo neurons. Von Economo neurons, located in the insular and anterior cingular cortices, are large neurons present only in mammals with high cognitive functions. Albeit these neurons' role is not yet known, evidence suggests they facilitate rapid long-range information integration. In this work, we provide theoretical and in-silico evidence that the dMRI signal is sensitive to the presence of Von Economo neurons as well as preliminary evidence on human dMRI images.}
}
@inproceedings{ISMRM2018_5230,
annote={ISMRM2018_5230},
pages={5230},
file={ISMRM2018_5230.pdf:ISMRM2018_5230.pdf:PDF},
title={Prediction of Neurite Indices From Diffusion Tensor Imaging in the human cerebral cortex.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5230.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Hikaru Fukutomi and Thai Akasaka and Koji Fujimoto and Takayuki Yamamoto and Tomohisa Okada and Kaori Togashi and Takuya Hayashi},
abstract={Recent studies suggest that Neurite Orientation Dispersion and Density Imaging (NODDI) provides valuable information about cortical neurites. However, it requires lengthy time to acquire multi-shell data of diffusion weighted imaging (DWI), as well as to calculate parameters, neurite density index (NDI) and orientation dispersion index (ODI). We propose a method to estimate cortical NDI and ODI from diffusion tensor imaging (DTI), which is based on a mathematical relationship between NODDI and DTI assuming negligible cerebrospinal fluid (CSF) in the cortex. We also show the accuracy and time for scanning and computation.}
}
@inproceedings{ISMRM2018_5231,
annote={ISMRM2018_5231},
pages={5231},
file={ISMRM2018_5231.pdf:ISMRM2018_5231.pdf:PDF},
title={Stick, ball and plane phantoms for validation of diffusion {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5231.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Karin Bryskhe and Johan Larsson and Dan Lundberg and Greta Eklund and Hong Jiang and Filip Szczepankiewicz and Daniel Topgaard},
abstract={When using quantitative measurements, sensitive to subtle errors, access to a stable reference object is crucial to validate parameter accuracy and system fluctuations. Here, we propose three complementary phantoms providing ideal systems for validation of metrics of diffusivity, microscopic anisotropy and compartment orientation. We have used liquid crystals to design phantoms exhibiting local diffusion tensors with normalized anisotropy (
DΔ) equal to the theoretical values of +1 (sticks), 0 (balls), as well as –½ (planes). We also confirm that our proposed phantoms have the desired properties with regards to voxel-average diffusion tensors and microscopic diffusion tensors.}
}
@inproceedings{ISMRM2018_5232,
annote={ISMRM2018_5232},
pages={5232},
file={ISMRM2018_5232.pdf:ISMRM2018_5232.pdf:PDF},
title={Microscopic diffusion anisotropy imaging in the kidneys},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5232.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Fabio Nery and Matt G Hall and David L Thomas and Enrico Kaden and Filip Szczepankiewicz and Isky Gordon and Chris A Clark},
abstract={Diffusion tensor imaging (DTI) is a widely used diffusion weighted imaging (DWI) approach, successful owing to its sensitivity to changes in tissue microstructure. Recent advances in diffusion MRI acquisition using arbitrary b-tensor shapes allow the in-vivo estimation of tissue microscopic fractional anisotropy (μFA), which unlike conventional fractional anisotropy (FA) is not confounded by orientation dispersion. The aim of this work is to investigate, for the first time, the feasibility of μFA quantification in the kidneys of healthy volunteers.}
}
@inproceedings{ISMRM2018_5233,
annote={ISMRM2018_5233},
pages={5233},
file={ISMRM2018_5233.pdf:ISMRM2018_5233.pdf:PDF},
title={Robust and fast {MCMC} sampling of diffusion {MRI} microstructure models},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5233.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Robbert Leonard Harms and Alard Roebroeck},
abstract={In this work we extend the Maastricht Diffusion Toolbox (MDT) software package with MCMC capabilities, thereby introducing robust and fast sampling of diffusion MRI microstructure models. MDT's object oriented modular design allows arbitrary specification and combination of models, likelihood functions, prior functions and proposal distributions. GPU based computations allow for ~80x faster MCMC sampling; e.g. the 81 volume example NODDI dataset can be sampled with 15000 samples in 1.5 hour, making MDT suitable for probabilistic inference of all implemented models, both dMRI microstructure as quantitative MRI models. The software is open source and freely available at https://github.com/cbclab.}
}
@inproceedings{ISMRM2018_5234,
annote={ISMRM2018_5234},
pages={5234},
file={ISMRM2018_5234.pdf:ISMRM2018_5234.pdf:PDF},
title={Unified multi-modal characterization of microstructural parameters of brain tissue using diffusion {MRI} and multi-echo T2 data},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5234.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Erick Jorge Canales-Rodríguez and Marco Pizzolato and Yasser Alemán-Gómez and Nicolas Kunz and Caroline Pot and Jean-Philippe Thiran and Alessandro Daducci},
abstract={In this study we propose a theoretical model to estimate different microstructure indices from diffusion MRI and multi-echo T2 (MET2) data. The proposed estimation framework takes into account the common and complementary information provided by both modalities. While the MET2 data allow us to model the myelin compartment, the diffusion data enable us to better characterize the intra-axonal and extra-axonal compartments. Results from numerical experiments support the hypothesis that the new unified estimation is more accurate than the alternative approach based on the individual sequential fitting of both image modalities. The performance was stable for noise levels commonly found in clinical protocols.}
}
@inproceedings{ISMRM2018_5235,
annote={ISMRM2018_5235},
pages={5235},
file={ISMRM2018_5235.pdf:ISMRM2018_5235.pdf:PDF},
title={Estimating axon diameter distributions beyond the physical limits of acquisition capabilities},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5235.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Mark Drakesmith and Suryanarayana Umesh Rudrapatna and Silvia de Santis and Derek K Jones},
abstract={Estimation of axon diameter distributions (ADDs) is hindered by the fact that axon diameters below a certain limit, which are prevalent throughout the nervous system, are invisible to a diffusion MRI protocol. Here we propose a simple modification to the AxCaliber protocol where only the portions of the ADD that can feasibly generate a signal are modelled, by fitting to a truncated distribution. We show in simulations and human data acquired on a high-gradient (300mT/m) system that using this approach produces ADD estimates much closer to those observed in histology.}
}
@inproceedings{ISMRM2018_5236,
annote={ISMRM2018_5236},
pages={5236},
file={ISMRM2018_5236.pdf:ISMRM2018_5236.pdf:PDF},
title={Microstructure characterisation of fixed prostate tissue using ultra high-resolution diffusion-weighted {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5236.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Maira Tariq and Andrada Ianus and Nyoman Kurniawan and Gary Cowin and Daniel C Alexander and Roger M Bourne and Eleftheria Panagiotaki},
abstract={This work explores ultra-high field microimaging of prostate tissue using diffusion compartment modelling. The acquired ultra-high-resolution data provides a unique opportunity to investigate the accuracy of the diffusion estimates as well as the contribution of various tissue components to the diffusion signal. We compare several multi-compartment models to explore the best microstructure model for prostate tissue. We find plausible results for the data and models used, which will be compared to corresponding histology. Future work will use more samples and extend the models compared to get a comprehensive analysis of the data.}
}
@inproceedings{ISMRM2018_5237,
annote={ISMRM2018_5237},
pages={5237},
file={ISMRM2018_5237.pdf:ISMRM2018_5237.pdf:PDF},
title={Voxel size matters: big voxels are required to generate realistic extra-axonal d{MRI} signals from Monte Carlo simulations},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5237.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={David Romascano and Jonathan Rafael-Patino and Ileana Jelescu and Muhamed Barakovic and Tim B. Dyrby and Jean-Philippe Thiran and Alessandro Daducci},
abstract={Monte Carlo simulations provide diffusion MRI signals that can be used to evaluate microstructure models, but that can also be incorporated into microstructure reconstruction methods. It is therefore important for the generated signals to be as realistic as possible. This work shows preliminary evidence that, in the case of white matter models, the symmetry of the perpendicular extra-axonal signal generated with Monte Carlo simulations depends on the voxel size. Simulations corresponding to millimeter-sized voxels should therefore be computed using substrates of equivalent size, or by averaging signals generated from multiple small voxels.}
}
@inproceedings{ISMRM2018_5238,
annote={ISMRM2018_5238},
pages={5238},
file={ISMRM2018_5238.pdf:ISMRM2018_5238.pdf:PDF},
title={Deep learning based segmentation of cardiomyocytes to aid numerical simulations of diffusion cardiovascular magnetic resonance},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5238.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jan N Rose and Wee Zhao Chua Khoo and Sonia Nielles-Vallespin and Pedro F Ferreira and David N Firmin and Andrew D Scott and Denis J Doorly},
abstract={To better understand how the underlying microstructure and pathology affect the DT-CMR signal in vivo, more realistic numerical models that account for irregular myocyte configurations such as sheetlets are necessary. We manually segmented cardiomyocytes from pig histology and confirmed that the resulting substrate is representative of the local microstructure through automatic segmentation of the surrounding tissue with a convolutional neural network. Monte Carlo random walk simulations, covering short and long mixing times and varying compartment diffusivities, show a mismatch between the results for the histology-based substrate and a simple cuboid model with comparable ECV and mean cell size.}
}
@inproceedings{ISMRM2018_5239,
annote={ISMRM2018_5239},
pages={5239},
file={ISMRM2018_5239.pdf:ISMRM2018_5239.pdf:PDF},
title={Diffusion Weighting with Linear and Planar Encoding Solves Degeneracy in Parameter Estimation},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5239.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Bibek Dhital and Marco Reisert and Elias Kellner and Valerij G. Kiselev},
abstract={While estimating parameters of tissue microstructure models has never been simple, the recently discovered bi-modality (degeneration) of objective function in parameter space render it highly challenging. This study proposes a response to this challenge based on combining the commonly used linear encoding (the b-matrix with the diagonal 0,0,b) with the planar encoding (b,b,0). The signal was simulated in the whole parameter space of the standard model of brain white matter. Exhaustive search in this space demonstrates the absence of bi-modality when results for both encoding schemes are treated together.}
}
@inproceedings{ISMRM2018_5240,
annote={ISMRM2018_5240},
pages={5240},
file={ISMRM2018_5240.pdf:ISMRM2018_5240.pdf:PDF},
title={Constrained analysis of b-tensor encoding diffusion data with multiple echo times allows estimation of compartment-specific T2 relaxation times in white matter.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5240.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Björn Lampinen and Filip Szczepankiewicz and Daniel Topgaard and Oskar Hansson and Danielle van Westen and Markus Nilsson},
abstract={We used b-tensor encoding and multiple echo times to estimate the separate T2 relaxation times and apparent fractions of white matter compartments. Nineteen elderly subjects were imaged and data were analyzed using a constrained ‘ball-and-stick’ diffusion-relaxation model. Results show that the ‘ball’ T2 relaxation time is inversely related to the fraction of ‘sticks’ in white matter lesions and that the ‘stick’ T2 relaxation time may be sensitive to the axonal diameter. The approach could be useful to characterize white matter damage.}
}
@inproceedings{ISMRM2018_5241,
annote={ISMRM2018_5241},
pages={5241},
file={ISMRM2018_5241.pdf:ISMRM2018_5241.pdf:PDF},
title={Revised {NODDI} model for diffusion {MRI} data with multiple b-tensor encodings},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5241.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Michele Guerreri and Filip Szczepankiewicz and Björn Lampinen and Markus Nilsson and Marco Palombo and Silvia Capuani and Hui Zhang},
abstract={This work proposes a revision of the NODDI model to relate brain tissue microstructure to the new generation of diffusion MRI data with multiple b-tensor encodings. NODDI was developed originally for conventional multi-shell diffusion data acquired with linear tensor encoding (LTE). While adequate for LTE data, it has been shown to be incompatible with data using spherical tensor encoding (STE). We embed a different set of assumptions in NODDI, while retaining the tortuosity constraint, to accommodate both LTE and STE data. Experiments with human data with multiple b-tensor encodings confirm the efficacy of the revision.}
}
@inproceedings{ISMRM2018_5242,
annote={ISMRM2018_5242},
pages={5242},
file={ISMRM2018_5242.pdf:ISMRM2018_5242.pdf:PDF},
title={Isotropic Diffusometry {MRI} of the human brain},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5242.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Alexandru V Avram and Joelle E Sarlls and Peter J Basser},
abstract={From diffusion MRI data acquired with isotropic diffusion encoding over a wide range of b-values, we estimate intravoxel distributions of mean diffusivities using a regularized Inverse Laplace Transform analysis. In vivo spectra of intra-voxel mean diffusivities measured in healthy subjects show consistent single-peak distributions in most brain regions, with subtle differences between white matter, cortical gray matter, subcortical gray matter, corpus callosum and cerebrospinal fluid. This non-invasive, model-free, whole-brain approach to quantifying spectra of intrinsic tissue water mobilities could improve the clinical diagnosis and characterization of stroke, cancer and other diseases.}
}
@inproceedings{ISMRM2018_5243,
annote={ISMRM2018_5243},
pages={5243},
file={ISMRM2018_5243.pdf:ISMRM2018_5243.pdf:PDF},
title={Quantification of white matter pathologies by a diffusion {MRI} technique modeling both intra- and extra-axonal compartments},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5243.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Chunyu Song and Tsen-Hsuan Lin and Peng Sun and Sheng-Kwei Song},
abstract={A new diffusion MRI histology (D-Histo) is proposed to model both intra- and extra-axonal diffusion as well as isotropic diffusion components within an image voxel. Both Monte-Carlo simulation, in vivo MRI of EAE mouse optic nerve and post-MRI histology were used to validate this approach. The intra-axonal fraction derived from D-Histo more accurately assessed fiber fraction and the intra-axonal axial diffusivities (AD) it derives more sensitively reflected axonal injury.}
}
@inproceedings{ISMRM2018_5244,
annote={ISMRM2018_5244},
pages={5244},
file={ISMRM2018_5244.pdf:ISMRM2018_5244.pdf:PDF},
title={Axon Diameter Mapping Independent of Crossing Structures using Spherical Mean Technique},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5244.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Qiuyun Fan and Aapo Nummenmaa and Thomas Witzel and Ned Ohringer and Qiyuan Tian and Lawrence L Wald and Susie Y. Huang and Eric C. Klawiter},
abstract={Current approaches to axonal size estimation by diffusion MRI assume a single fiber bundle, which limits its application to a few white matter tracts in the healthy human brain. We introduce a new approach to per-voxel axon diameter and volume fraction estimation inspired by the spherical mean framework that is robust to fiber crossings and orientation dispersion. We use this technique to estimate whole brain axon diameter and volume fraction in 6 healthy subjects scanned on the 3T Connectome scanner and demonstrate the utility of this approach to characterize white matter pathology in a patient with multiple sclerosis.}
}
@inproceedings{ISMRM2018_5245,
annote={ISMRM2018_5245},
pages={5245},
file={ISMRM2018_5245.pdf:ISMRM2018_5245.pdf:PDF},
title={Assessing feasibility and reproducibility of a bundle-specific framework on in vivo axon diameter estimates at 300mT/m},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5245.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Muhamed Barakovic and Gabriel Girard and David Romascano and Jonathan Rafael-Patino and Maxime Descoteaux and Giorgio Innocenti and Derek K. Jones and Jean-Philippe Thiran and Alessandro Daducci},
abstract={In vivo quantitative estimation of axon diameter in the white matter is a potential new tool for studying the structural and functional architecture of the brain. Recently, the feasibility of axon diameter estimation with diffusion-weighted MRI (DW-MRI) has been questioned. In this work, we explore the feasibility of bundle-specific axon diameter mapping in the context of a reproducibility study using the Convex Optimization Modeling for Microstructure informed Tractography (COMMIT) framework. Our results show that DW-MRI axon diameter estimatesof the corpus callosum and of the corticospinal tract are comparable to histological reports in previous studies.}
}
@inproceedings{ISMRM2018_5246,
annote={ISMRM2018_5246},
pages={5246},
file={ISMRM2018_5246.pdf:ISMRM2018_5246.pdf:PDF},
title={Mapping Normative Mean Apparent Propagator Derived Microstructural Parameters},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5246.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Adam Scott Bernstein and Alexandru V Avram and Amber Simmons and Martin Cota and Neville Gai and Neekita Jikaria and Anita Moses and Christine Turtzo and Lawrence Latour and Dzung Pham and John A Butman and Peter J Basser},
abstract={This work establishes preliminary data as well as a processing pipeline to generate normative MAP-MRI parameter maps. This normative data can be used to better understand the values and variation of different diffusion-derived microstructural parameters found in healthy humans. This information can then be used as a baseline for future research or clinical projects.
}
}
@inproceedings{ISMRM2018_5247,
annote={ISMRM2018_5247},
pages={5247},
file={ISMRM2018_5247.pdf:ISMRM2018_5247.pdf:PDF},
title={White Matter Microstructural Change Following Traumatic Brain Injury Assessed by Simultaneous Multi-Slice Multi-Shell Diffusion {MRI} - A Preliminary Study},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5247.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ping-Hong Yeh and Nicholas Goh and Cheng Guan Koay and Chihwa Song and Wei Liu and Grant Bonavia and John Ollinger and Gerard Riedy},
abstract={Mild traumatic brain injury (mTBI) is difficult to diagnose and characterize. In this study, we applied simultaneous multi-slice multi-shell diffusion MRI to assess white matter microstructural changes in chronic military mTBI. Preliminary results showed parameters derived from Mean Apparent Propagator MRI method are superior to the parameters derived from diffusion tensor imaging or diffusion kurtosis imaging in differentiating tissues with distinct structural and architectural features and thus has increased ability to identify microstructural changes in mTBI.}
}
@inproceedings{ISMRM2018_5248,
annote={ISMRM2018_5248},
pages={5248},
file={ISMRM2018_5248.pdf:ISMRM2018_5248.pdf:PDF},
title={Effects of tissue microstructure on water resonance line-shape in post-mortem rat brain},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5248.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Sean Foxley and Gregory S Karczmar and Kazutaka Takahashi},
abstract={Many neurodegenerative diseases are characterized by microstructural changes in white matter, including demyelination and cell loss. Such changes have been demonstrated to produce measurable effects on the MR signal. This work examines these effects from post-mortem fixed rat brain on voxel-wise, high-resolution water spectra acquired using a multi-gradient echo pulse sequence. Results demonstrate that components of the spectra are differentially affected by both white matter orientation relative to B0 as well as tissue microstructure. This suggests that water proton spectra may be sensitive to the tissue microenvironment and could serve as potential MRI based biomarkers of neurodegenerative diseases.}
}
@inproceedings{ISMRM2018_5249,
annote={ISMRM2018_5249},
pages={5249},
file={ISMRM2018_5249.pdf:ISMRM2018_5249.pdf:PDF},
title={Effects of early alcohol exposure on functional organization and microstructure of a visual-tactile integrative circuit},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5249.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Shiyu Tang and Su Xu and Alexandre E. Medina and Rao Gullapalli},
abstract={Children with fetal alcohol spectrum disorders (FASD) often have deficits associated with multisensory processing. Because ethanol disrupts activity-dependent neuronal plasticity, a process that is essential for refining connections during cortical development, we hypothesize that early alcohol exposure results in alterations in multisensory cortical networks, which could explain the multisensory processing deficits seen in FASD. Here, we use a gyrencephalic animal model to test the prediction that early alcohol exposure alters the functional connectivity and microstructural features of a visual-tactile integrative area with resting-state functional magnetic resonance imaging and diffusion kurtosis imaging.}
}
@inproceedings{ISMRM2018_5250,
annote={ISMRM2018_5250},
pages={5250},
file={ISMRM2018_5250.pdf:ISMRM2018_5250.pdf:PDF},
title={Axonal distributions: a simulation study to estimate Diffusion {MRI} signal contributions in white matter},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5250.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Andrea Chiappiniello and Valentina Reggioli and Roberto Tarducci and Marco Catani and Flavio Dell’Acqua},
abstract={In the last decade, many techniques that use diffusion MRI to obtain an axon diameter estimate as micro-structural integrity index have been developed. However, recent studies showed that diffusion signal may be not sensitive enough to quantify axon diameters. In this study, we simulated a simplified model of white matter to evaluate the contribution of intra-axonal compartment to diffusion MRI signal in white matter. We found that, even in distributions with a small mean diameter, big axons still substantially contribute to the total axonal volume. We conclude that quantifications of human axon diameters from diffusion MRI may still be possible.}
}
@inproceedings{ISMRM2018_5251,
annote={ISMRM2018_5251},
pages={5251},
file={ISMRM2018_5251.pdf:ISMRM2018_5251.pdf:PDF},
title={White Matter Fiber Structure Revealed by Synthetic {MRI} of the Longitudinal Magnetization Relaxation Rate (R1): Effects of Age at 1.5T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5251.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Hernan Jara and Stephan W Anderson and Osamu Sakai},
abstract={Purpose: To investigate the potential of R1-weighted Synthetic-MRI for unraveling the microstructure of white matter and for constructing accurate high resolution brain connectomes. Methods: Eighteen research subjects ranging in age from 0.6 to 87years were scanned with multispectral qMRI (T1, R1, T2 and PD) and analyzed with R1-weighted Synthetic MRI. Results: connectome renderings as function of increasing age show the expected increased WM track bundle packing and anatomical distributions evolution as function of age. Conclusion: R1-weighted WM Fibrography is a promising complementary alternative to DTI-WM Tractography for studying the microarchitecture of white matter.}
}
@inproceedings{ISMRM2018_5252,
annote={ISMRM2018_5252},
pages={5252},
file={ISMRM2018_5252.pdf:ISMRM2018_5252.pdf:PDF},
title={Ultra-High Gradient Diffusion {MRI} Reveals Distinct Microstructural Changes in Diffuse Gliomas Before and After Radiation Therapy},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5252.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ina Ly and Qiuyun Fan and Barbara Wichtmann and Aapo Nummenmaa and Ovidiu Andronesi and Brian Nahed and William Curry and Daniel Cahill and Tracy Batchelor and Jayashree Kalpathy-Cramer and Bruce Rosen and Susie Huang and Elizabeth Gerstner},
abstract={The lack of a sensitive imaging method capable of capturing the full extent of glioma cell infiltration represents a significant challenge to accurate treatment planning and monitoring of therapeutic response. Here, using a recently developed diffusion MRI method (Linear Multi-Scale Model; LMM), we estimated the changes in restricted, hindered and free water in six glioma patients pre- and post-treatment. We found scan-to-scan reproducibility of diffusion profiles in normal brain and identified distinct diffusion profiles in the tumor and peritumoral regions at different time points, thus highlighting the robustness of the LMM and its feasibility in the clinical setting.}
}
@inproceedings{ISMRM2018_5253,
annote={ISMRM2018_5253},
pages={5253},
file={ISMRM2018_5253.pdf:ISMRM2018_5253.pdf:PDF},
title={Brain Microstructure Characterization: Initial Experience and Optimization of protocols for the Siemens Terra 7T System},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5253.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Maria Roxana Stefanescu and David Lohr and Aleksander Kosmala and Maxim Terekhov and Laura Maria Schreiber},
abstract={Recent technological advances have brought new ultrahigh-field MRI (UHF) systems to the market, which nourish the expectation of better image quality with vendor-supplied sequences than with older systems. This would be an important factor for a wider distribution of UHF system and, thus, for moving UHF technology forward from a research tool to a clinical application. Therefore, the aim of this study was to perform a pilot study to assess the new Siemens Magnetom Terra 7T system with regard to typical clinical applications of 7T MRI in the brain.}
}
@inproceedings{ISMRM2018_5254,
annote={ISMRM2018_5254},
pages={5254},
file={ISMRM2018_5254.pdf:ISMRM2018_5254.pdf:PDF},
title={Characterization of white matter structures growth in common marmosets},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5254.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Fumiko Seki and Keigo Hikishima and Yuji Komaki and Marin Nishio and Junichi Hata and Akiko Uematsu and Norio Okahara and Erika Sasaki and Hideyuki Okano},
abstract={This study investigated developmental patterns of white matter structures in common marmosets using DTI and MTR. Longitudinal MRI was performed to 23 marmosets at the age of 1-34 months. Tract-based ROIs were created for assessment of major fiber bundles. Population growth trajectories of association fibers estimated using Gompertz function showed different developmental patterns. As previously reported, inferior longitudinal fasciculus (ILF) showed earlier maturation with slow speed, whereas inferior fronto-occipital fasciculus (IFOF) showed slower maturation with fast speed observed in MTR, RD and FA. It indicates ILF might mature compared with IFOF at birth, which was consistent with human studies.}
}
@inproceedings{ISMRM2018_5255,
annote={ISMRM2018_5255},
pages={5255},
file={ISMRM2018_5255.pdf:ISMRM2018_5255.pdf:PDF},
title={Non-invasive assessment of glioma microstructure using {VERDICT} {MRI} with comparison to histopathology},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5255.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Fulvio Zaccagna and Frank Riemer and Andrew N. Priest and Kieren S. J. Allinson and Mary A. McLean and James T. Grist and Tomasz Matys and Jonathan H. Gillard and Colin Watts and Stephen J. Price and Martin J. Graves and Ferdia A. Gallagher},
abstract={Gliomas are characterized by diffuse infiltration, high heterogeneity and poor prognosis. Imaging tumor heterogeneity may improve diagnosis and therapy planning. The Vascular, Extracellular and Restricted Diffusion for Cytometry in Tumors (VERDICT) MRI technique is a multi-compartmental model that exploits tissue microstructure. This preliminary study demonstrated the feasibility of translating VERDICT MRI in human brain imaging to investigate the microstructure of glioma with an abbreviated protocol. We demonstrated that VERDICT-derived cell size does not differ from the measured size on pathological slides and we found clear trends in LGG and HGG that may be useful to better differentiate types of glioma.}
}
@inproceedings{ISMRM2018_5256,
annote={ISMRM2018_5256},
pages={5256},
file={ISMRM2018_5256.pdf:ISMRM2018_5256.pdf:PDF},
title={Microstructure-mesh projection: Combining shape analysis with diffusion {MRI} models},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5256.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Kirsten Lynch and Yonggang Shi and Arthur Toga and Kristi Clark},
abstract={The hippocampus is a heterogeneous structure consisting of subfields with distinct cytoarchitectonic and connectivity patterns. In order to capture the complexity of hippocampal structure, we propose a framework that combines the localized specificity of shape analysis with the microstructural sensitivity obtained with diffusion MRI models. The microstructure-mesh projection pipeline projects local model parameters within the hippocampus onto the surface to enable visualization and analysis of regional microstructural features. In a pediatric dataset, regional patterns of microstructural maturation within the hippocampus were observed.}
}
@inproceedings{ISMRM2018_5257,
annote={ISMRM2018_5257},
pages={5257},
file={ISMRM2018_5257.pdf:ISMRM2018_5257.pdf:PDF},
title={Diffusion Tensor Imaging to Investigate Diet-induced Changes in Neuronal Tissue Microstructure and Organization},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5257.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Maribel Torres Velazquez and M. Elizabeth Meyerand and John-Paul J. Yu},
abstract={Altered gut microbiome populations are associated with a broad range of neurodevelopmental disorders. Disruption of the gut microbiome via dietary intake has been shown to influence brain function and behavior in animal models. Utilizing diffusion tensor imaging we identified global changes in white matter structural integrity occurring in a diet-dependent manner. Subsequent diet-crossover experiments demonstrate the varying permanence of these diet-induced changes and the degree of plasticity associated with these changes. These studies allow us to further explore our understanding of the gut-brain-microbiota axis by revealing possible links between altered and dysbiotic gut microbiome populations and changes in brain structure.}
}
@inproceedings{ISMRM2018_5258,
annote={ISMRM2018_5258},
pages={5258},
file={ISMRM2018_5258.pdf:ISMRM2018_5258.pdf:PDF},
title={{ASSOCIATION} {OF} {MID}-{LIFE} {VASCULAR} {RISK} {FACTORS} {AND} {LATE}-{LIFE} {WHITE} {MATTER} {MICROSTRUCTURE} {IN} {COGNITIVELY} {NORMAL} {OLDER} {WOMEN}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5258.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Vijay Venkatraman and Christopher Steward and Cassandra Szoeke and Rowa Aljondi and Patricia Desmond},
abstract={In this study, we explored the use of diffusion imaging measures, as possible biomarkers in clinical trials. We examined the association between vascular risk factors and white matter microstructure in normal aging. Consequently, we studied the relationship between composite and individual mid-life vascular risk factors with late-life white matter microstructure in a cohort of cognitively normal women. The results showed no association between composite score and microstructure. However, there was a significant association between systolic blood pressure and white matter microstructure such as the corpus callosum. Future work is needed to understand this relationship and its effect on cognition.}
}
@inproceedings{ISMRM2018_5259,
annote={ISMRM2018_5259},
pages={5259},
file={ISMRM2018_5259.pdf:ISMRM2018_5259.pdf:PDF},
title={Brain microstructure alterations associated to Alzheimer's disease assessed by diffusion tensor and neurite orientation dispersion and density imaging.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5259.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Emma Muñoz-Moreno and Laura Obrado and Raúl Tudela and Xavier López-Gil and Gemma Piella and Guadalupe Soria},
abstract={NODDI characterizes neurite orientation dispersion (ODI) and intracellular volume fraction (ICVF), related to neurite density, based on diffusion magnetic resonance imaging. In this study, we have applied NODDI to evaluate excised brains of TgF344-AD, a transgenic rat model of Alzheimer’s disease (AD) and compared them with brains from control rats. Specific brain regions were evaluated: amygdala, caudate putamen, insular cortex and antero-dorsal and posterior hipppocampi. ODI and ICVF shown a different distribution in AD and control rats, with a tendency to higher values in AD, that could not be observed by standard diffusion parameters such as fractional anisotropy (FA).}
}
@inproceedings{ISMRM2018_5260,
annote={ISMRM2018_5260},
pages={5260},
file={ISMRM2018_5260.pdf:ISMRM2018_5260.pdf:PDF},
title={Characterisation of microstructural alterations in a weight drop m{TBI} rat model: a longitudinal diffusion {MRI} and histological analysis},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5260.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Kim Braeckman and Benedicte Descamps and Leen Pieters and Karen Caeyenberghs and Christian Vanhove},
abstract={TBI is the leading cause of acquired disability of young adults and due to the subtle nature, conventional scans show no evidence of injury. In this multi-shell longitudinal diffusion MRI study of mTBI in rat brain we found that DKI and white matter metrics can be used to follow up recovery in the brain at least until one week after injury. Moreover, histological analysis showed that changes in the metrics could be explained by inflammation and neurofilament compaction. On the other hand, DTI metrics could not differentiate between the sham and TBI group and were comparable in the two groups.}
}
@inproceedings{ISMRM2018_5261,
annote={ISMRM2018_5261},
pages={5261},
file={ISMRM2018_5261.pdf:ISMRM2018_5261.pdf:PDF},
title={The contribution of astrocytic aquaporin-4 to gray and white matter diffusion ansiotropy},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5261.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Andre Obenaus and Jacqueline Coats and Andrew Fukada and Wei Sun and Jerome Badaut},
abstract={We investigated the impact of water channels (aquaporin 4; AQP4) on DTI metrics after silencing expression of AQP4 in the juvenile brain. We observed a significant reduction in AQP4 expression after RNA silencing of AQP4 (siAQP4) along with significantly altered DTI metrics in the cortex but not the corpus callosum (CC). No changes in cellular constituents were found. Histological studies have reported decreased AQP4 expression in acquired brain injuries. Thus, our novel findings suggest that reductions in AQP4 expression may underlie the changes in DTI metrics that are often reported in DTI studies of stroke, traumatic brain injury and others.}
}
@inproceedings{ISMRM2018_5262,
annote={ISMRM2018_5262},
pages={5262},
file={ISMRM2018_5262.pdf:ISMRM2018_5262.pdf:PDF},
title={Diffusion tensor changes in acute neuroinflammation in rats},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5262.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Eugene Kim and Camilla Simmons and Karen Randall and Brigida Ranieri and Paula Sureda-Gibert and Tobias Wood and Carmine Pariante and Federico Turkheimer and Diana Cash},
abstract={Many neurodegenerative and psychiatric disorders feature low level neuroinflammation that is insidious yet difficult to diagnose in vivo. Here we explore the possibility of detecting acute neuroinflammation induced by systemic administration of lipopolysaccharide (LPS) in rats using in vivo diffusion tensor imaging (DTI) at 9.4T. Subtle yet widespread decreases in fractional anisotropy and increases in mean diffusivity were found in LPS-treated rats. Our results confirm the notion that DTI metrics are potential sensitive biomarkers of the dynamic inflammatory response in the brain, raising the possibility of utilizing DTI as a non-invasive in vivo assay for therapeutic interventions.}
}
@inproceedings{ISMRM2018_5263,
annote={ISMRM2018_5263},
pages={5263},
file={ISMRM2018_5263.pdf:ISMRM2018_5263.pdf:PDF},
title={Combining diffusion and perfusion weighted {MRI} measurements for disease and treatment monitoring in Multiple Sclerosis},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5263.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Madalina E Tivarus and Xing Qiu and Nicole Zizzi and Giovanni Schifitto},
abstract={In this large sample retrospective study of MS patients with different diagnoses and treatment regimens we investigated interactions between imaging metrics and age, MS phenotype and types of treatment and longitudinal changes associated with disease modifying treatments. We assessed WM injury using DTI metrics (FA, MD) and vascular changes (CBF and CBV) using perfusion DSC, in corpus callosum and in its cortical projections. We found significant correlations of perfusion with age and DTI metrics with disease type and medication, suggesting that advanced neuroimaging methods such as DTI should become integrated into the clinical evaluation of MS patients for improved management.}
}
@inproceedings{ISMRM2018_5264,
annote={ISMRM2018_5264},
pages={5264},
file={ISMRM2018_5264.pdf:ISMRM2018_5264.pdf:PDF},
title={Free-Water Elimination Diffusion Tensor Imaging to Assess Nerve Recovery in Excised Rat Nerve},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5264.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Shashank Manjunath and Isaac V. Manzanera-Esteve and Wesley P. Thayer and Mark D. Does and Richard D. Dortch},
abstract={We present our findings using a free water elimination model, which allows for the characterization of edema signal in diffusion measurements. We validate this model on ex vivo rat nerve data after sham surgeries on the sciatic nerve. The free water model effectively accounts for inflammation following sham surgeries, leading to increased accuracy in fractional anisotropy measurements throughout the recovery process. This model will be applied in other injury models (crush, transection/surgical repair) to test its ability to independently monitor inflammation/edema and nerve degeneration/regeneration.}
}
@inproceedings{ISMRM2018_5265,
annote={ISMRM2018_5265},
pages={5265},
file={ISMRM2018_5265.pdf:ISMRM2018_5265.pdf:PDF},
title={Diffusion tensor imaging in a rat model of brain stem ischemia reveals structural remodeling contralateral to the ischemic lesion},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5265.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Lydia Wachsmuth and Jens Minnerup and Jan-Kolja Strecker and Kai Diederich and Cornelius Faber},
abstract={Ischemic stroke of the brain stem affects a considerable number of human patients. However, mechanisms of degeneration and recovery are not well understood and animal models of brain stem ischemia are rare compared to models of cortical stroke. Here we implemented a rat model of brain stem ischemia and applied diffusion tensor MR imaging as a noninvasive means to assess structural connectivity. Probabilistic mapping and histology indicate structural remodeling at the level of thalamus. These results add evidence for a potential compensatory mechanism for the observed partial recovery after brain stem stroke.}
}
@inproceedings{ISMRM2018_5266,
annote={ISMRM2018_5266},
pages={5266},
file={ISMRM2018_5266.pdf:ISMRM2018_5266.pdf:PDF},
title={Diffusion Changes in Normal-Appearing White Matter in Tracts Affected by White Matter Hyperintensities},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5266.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Rozanna Meijboom and Susana Muñoz Maniega and Maria Valdés Hernández and Nathalie Royle and Zoe Morris and John Starr and Mark Bastin and Ian Deary and Joanna Wardlaw},
abstract={White matter hyperintensities (WMH) are common in older brains. We analyzed how WMH affect white matter (WM) tracts and particularly their normal-appearing WM (NAWM). We used MRI of 52 participants (72.2±0.7y) to quantify diffusion parameters of WMH-affected tracts. The intersections of tracts with WMH were identified and volumes quantified. Diffusion parameters were measured for tract-WMH, tract-NAWM and for tract-NAWM at different distances from the tract-WMH edge and from the edge of nearby—non-intersecting—WMH. Tract-NAWM showed a gradient of diffusion abnormalities away from tract-WMH and nearby-WMH. Tract-WMH diffusion and either tract-WMH volume or whole-brain WMH load, predicted tract-NAWM diffusion.}
}
@inproceedings{ISMRM2018_5267,
annote={ISMRM2018_5267},
pages={5267},
file={ISMRM2018_5267.pdf:ISMRM2018_5267.pdf:PDF},
title={Evaluating the effect of 3-n-butylphthalide on expression of aquaporin-4 by ultra-high b value diffusion weighted imaging in animal model with focal cerebral ischemia},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5267.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Baohong Wen and Dandan Zheng and Jingliang Cheng},
abstract={Previous studies have reported that 3-n-butylphthalide (NBP) had beneficial effects on stroke through multiple aspects, including decreasing the area of cerebral infarct, improving energy metabolism , inhibiting the inflammatory response and improving cerebral microvessels . Although the positive effects of NBP on cerebral ischemia and cerebral infarct have been verified in ischemic patients and animal models, the effects of NBP in aquaporin-4 (AQP-4) are still unclear. Recently, ultra-high diffusion weighted imaging was reported to be able to reflect AQP-4 changes . This study would like to evaluate the effect of 3-n-butylphthalide on expression of aquaporin-4 by ultra-high b value diffusion weighted imaging in animal model of focal cerebral ischemia at different time points.}
}
@inproceedings{ISMRM2018_5268,
annote={ISMRM2018_5268},
pages={5268},
file={ISMRM2018_5268.pdf:ISMRM2018_5268.pdf:PDF},
title={Early Apparent Diffusion Coefficient Deficit Correlates to Final Outcome in Experimental Neonatal Hypoxic Ischemia},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5268.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yu-Chieh Jill Kao and Chia-Feng Lu and Chao-Ching Huang and Cheng-Yu Chen},
abstract={Changes in apparent diffusion coefficient (ADC) at 2 h after hypoxic ischemia (HI) in neonatal rats showed the significant correlation to the final lesion severity. The early ADC deficit appeared within 6 h after HI injury may serve as an index for outcome prediction and the translational evidence to stratify neonates for hypothermia treatment.}
}
@inproceedings{ISMRM2018_5269,
annote={ISMRM2018_5269},
pages={5269},
file={ISMRM2018_5269.pdf:ISMRM2018_5269.pdf:PDF},
title={Diffusion Tensor Imaging of Excised Rat Nerve Following Transection and Surgical Repair},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5269.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Isaac Vicente Manzanera Esteve and Angel F Farinas Chopite and Marlieke C Nussenbaum and Alonda C Pollins and Wes P Thayer and Mark D Does and Dortch D Richard},
abstract={Traumatic peripheral nerve injury (TPNI) from crushing and/or transection can lead to nerve degeneration distal to the site of injury and a temporary loss in sensorimotor function. In this study, we present our findings showing how high-resolution DTI and Tractography measurements of traumatic nerve injury in the sciatic nerve region are capable to identify and characterize nerve injury degeneration/regeneration and injury type in rats. Our findings suggest that DTI and Tractography are viable biomarkers of nerve regeneration and can provide with valuable information in the evaluation of therapeutic interventions}
}
@inproceedings{ISMRM2018_5270,
annote={ISMRM2018_5270},
pages={5270},
file={ISMRM2018_5270.pdf:ISMRM2018_5270.pdf:PDF},
title={Spinal cord cross section and {DTI} by vertebral level correlate superior and inferior to injury},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5270.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Devon M Middleton and Shiva Shahrampour and Chris J Conklin and Mahdi Alizadeh and Scott H Faro and Laura Krisa and MJ Mulcahey and Feroze B Mohamed},
abstract={Examination of diffusion and cord cross section by vertebral level in pediatric subjects has the potential to show useful information in injury diagnosis and prognosis. Correlations between DTI and cord cross section by vertebral level are shown superior and inferior to the injury site.
}
}
@inproceedings{ISMRM2018_5271,
annote={ISMRM2018_5271},
pages={5271},
file={ISMRM2018_5271.pdf:ISMRM2018_5271.pdf:PDF},
title={Gray Matter Myelin Alterations in Early and Late Relapsing-Remitting Multiple Sclerosis Evaluated with Quantitative Synthetic Magnetic Resonance Imaging: A Gray-Matter Based Spatial Statistics Analysis},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5271.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Christina Andica and Akifumi Hagiwara and Keigo Shimoji and Koji Kamagata and Asami Saito and Yuki Takenaka and Tomoko Maekawa and Saori Koshino and Ryusuke Irie and Akihiko Wada and Masaaki Hori and Kanako K Kumamaru and Kanako Sato and Kazumasa Yokoyama and Nobutaka Hattori and Shigeki Aoki},
abstract={Our study demonstrated that myelin volume fraction (MVF) and myelin volume (MyV) obtained by a multi-parametric quantitative synthetic MRI might be useful for evaluating gray matter (GM) myelin alterations and for monitoring disease progression in relapsing-remitting multiple sclerosis (RRMS) patients. GM-based spatial statistics analysis demonstrated decreased MVF in limbic, paralimbic and deep GM areas in the early-RRMS and in extensive areas of GM in the late-RRMS. In the meanwhile, MyV was found to be decreased in both RRMS groups compared to healthy subjects, with late-RRMS showing the lowest value and significantly correlated with disease duration.}
}
@inproceedings{ISMRM2018_5272,
annote={ISMRM2018_5272},
pages={5272},
file={ISMRM2018_5272.pdf:ISMRM2018_5272.pdf:PDF},
title={Discriminative Analysis of Regional Evolution of Iron and Myelin/Calcium in Deep Gray Matter of Multiple Sclerosis and Healthy Subjects},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5272.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ahmed M. Elkady and Dana Cobzas and Hongfu Sun and Gregg Blevins and Alan H Wilman},
abstract={We introduce Discriminative Analysis of Regional Evolution (DARE) of iron and myelin/calcium to assess specific changes in Deep Gray Matter (DGM) of Relapsing-Remitting Multiple Sclerosis (RRMS), Progressive MS (PMS) and corresponding age-matched healthy subjects, which we regress with disease severity. DARE enabled discriminative assessment of longitudinal changes in MS and demonstrated superior performance compared to conventional bulk analysis. Iron decrease and myelin/calcium increase and myelin/calcium changes, were the primary drivers of observed MRI longitudinal changes in RRMS and PMS DGM, respectively. Specific DARE measures of MS DGM can be used to predict MS Severity Score and may reflect complex disease pathology.}
}
@inproceedings{ISMRM2018_5273,
annote={ISMRM2018_5273},
pages={5273},
file={ISMRM2018_5273.pdf:ISMRM2018_5273.pdf:PDF},
title={Surface-based Quantitative Susceptibility Mapping of Cortical Pathology in Multiple Sclerosis},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5273.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Marco Castellaro and Roberta Magliozzi and Alessandro Palombit and Stefania Montemezzi and Francesca Benedetta Pizzini and Alessandra Bertoldo and Massimiliano Calabrese},
abstract={Multiple Sclerosis has been showed to be characterized by extent cortical sub-pial demyelination and iron alterations. Moreover, a “surface-in” gradient of pathology has been showed to be present in MS. In this study, we used QSM to investigate iron and/or myelin changes in the whole cortex. Moreover, we exploit surface-based methods to clarify the presence of a laminar specific changes in cortical susceptibility of Relapsing-Remitting MS patients.}
}
@inproceedings{ISMRM2018_5274,
annote={ISMRM2018_5274},
pages={5274},
file={ISMRM2018_5274.pdf:ISMRM2018_5274.pdf:PDF},
title={Optimization of {CEST} {MRI} at 7 Tesla for Detection of Cortical Gray Matter Pathology in Multiple Sclerosis},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5274.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Kristin Poole O'Grady and Samantha By and Bailey A. Box and Quinn R. Weinberg and Siddharama Pawate and Francesca R. Bagnato and Seth A. Smith},
abstract={Glutamate-sensitive chemical exchange saturation transfer (CEST) MRI has been applied in the human brain and shows promise for detecting pathology related to dysfunctional glutamate regulation. Glutamate abnormalities are linked to cortical gray matter (GM) pathology and cognitive impairment in multiple sclerosis (MS), but quantitative assessment techniques are lacking. We optimized and applied CEST MRI at 7.0T in phantoms and in vivo to evaluate sensitivity to glutamate and the effect of saturation pulse duration. Our results show increased CEST contrast in cortical GM of MS patients relative to controls and demonstrate the potential of CEST in characterizing GM damage in MS.}
}
@inproceedings{ISMRM2018_5275,
annote={ISMRM2018_5275},
pages={5275},
file={ISMRM2018_5275.pdf:ISMRM2018_5275.pdf:PDF},
title={{MR} Microscopy of Cortical Lesions Reveal Iron Loss in Individual Oligodendrocytes},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5275.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Stephen Dodd and Govind Nair and Seung-Kwon Ha and Daniel Reich and Alan Koretsky},
abstract={Imaging of cortical demyelination in chronic multiple sclerosis, has been challenging. Previous MRI studies have detecting signal changes in cortical lesions have been attributed to myelin loss and the presence of iron-laden microglia. Here we demonstrate, in a case study, that MR microscopy may readily identify individual iron-rich cells (primarily oligodendrocytes) and regions. In addition, MR microscopy is shown to allow detailed examination of the central vein signal in white matter lesions.}
}
@inproceedings{ISMRM2018_5276,
annote={ISMRM2018_5276},
pages={5276},
file={ISMRM2018_5276.pdf:ISMRM2018_5276.pdf:PDF},
title={Inconsistency in Grey Matter Volume Estimation of {MS} Patients: A Multi-Vendor Study at 3 Tesla},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5276.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Houshang Amiri and Stephanie Bosschaert and Iman Brouwer and Joost P.A. Kuijer and Jan C. de Munck and Marloes Hagens and Joep Killestein and Frederik Barkhof and Hugo Vrenken},
abstract={MR images are widely used to measure brain atrophy is neurodegenerative diseases. However, reliable evaluation of atrophy is hampered by between- and within-scanner variability and inconsistency. We investigated this in 21 multiple sclerosis patients scanned at three different scanners (twice at each scanner). Volumes of GM, WM and whole brain, as well as deep grey matter structures were assessed using SIENAX and FSL-FIRST, respectively. Voxel-based morphometry was used to localise variabilities in the brain. Our findings suggests that scanner-related factors and especially between-scanner variability, play a role in inconstancy of brain volume measurements.}
}
@inproceedings{ISMRM2018_5277,
annote={ISMRM2018_5277},
pages={5277},
file={ISMRM2018_5277.pdf:ISMRM2018_5277.pdf:PDF},
title={Comparison of Methods for Whole-Brain and Grey Matter Atrophy Assessment in Multiple Sclerosis},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5277.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Loredana Storelli and Maria A. Rocca and Elisabetta Pagani and Wim Van Hecke and Mark A. Horsfield and Nicola De Stefano and Alex Rovira and Jaume Sastre-Garriga and Jacqueline Palace and Diana Sima and Dirk Smeets and Massimo Filippi},
abstract={We compared different methods for whole-brain and grey matter (GM) atrophy estimation (ANTs v1.9, CIVET v2.1, FSL-SIENA(X) v5.0.1, Icometrix-MSmetrix v1.7 and SPM v12) in multiple sclerosis (MS). The accuracy and precision were evaluated for cross-sectional and longitudinal whole-brain and GM atrophy measures. All software showed high accuracy and comparable repeatability for cross-sectional measures. However, since there was poor reproducibility and high variability in cross-sectional and longitudinal atrophy measures, changes of MR scanner should be avoided. This study may help in the selection of a suitable pipeline, depending on the requirements of the application (research center, clinical setting or clinical trial).}
}
@inproceedings{ISMRM2018_5278,
annote={ISMRM2018_5278},
pages={5278},
file={ISMRM2018_5278.pdf:ISMRM2018_5278.pdf:PDF},
title={1H {MRS} study of glutamate excitotoxicity in hypothalamus of early multiple sclerosis patients},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5278.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Petra Hnilicová and Ema Kantorová and Hubert Poláček and Štefan Sivák and Michal Bittšanský and Kamil Zeleňák and Egon Kurča and Dušan Dobrota},
abstract={Multiple sclerosis (MS) is considered as an autoimmune disease with expanding axonal and neuronal degeneration in the spinal cord or cerebral cortex during the acute MS phase. The hypothalamus (HYP) is often overlooked yet controls important homeostatic functions. This
1H MRS study performed on 1.5 T MR scanner using 3D CSI with 10×10×12.5 mm
3 voxels was focused to altered HYP metabolism in early MS. Considering our results, increased Glx ratios with reduced mIns and tNAA ratios in HYP suggested glutamate excitotoxicity associated with glial activity and neuronal damage. This indicated that HYP plays an important role in early disease evolution.}
}
@inproceedings{ISMRM2018_5279,
annote={ISMRM2018_5279},
pages={5279},
file={ISMRM2018_5279.pdf:ISMRM2018_5279.pdf:PDF},
title={Examining Cortical Thickness Markers in Relapse Remitting Multiple Sclerosis},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5279.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Geoffrey Ngo and Ravi S Menon},
abstract={Recent evidence suggests that cortical pathology in Multiple Sclerosis (MS) does not affect all brain regions equally. We aim to investigate regional cortical MS pathology by using cortical thickness measures in a relapsing-remitting group (RRMS). Structural scans from 21 RRMS and 21 controls were processed using Freesurfer to obtain cortical thickness measurements. Group level analysis was performed to investigate the preference of sulcal and gyral thinning. Differences between gyri and sulci thickness between groups were also calculated to see if there was any evidence of cortical-layer specific thinning. Sulcal preference was shown and no layer specific thinning was observed.}
}
@inproceedings{ISMRM2018_5280,
annote={ISMRM2018_5280},
pages={5280},
file={ISMRM2018_5280.pdf:ISMRM2018_5280.pdf:PDF},
title={Indirect assessment of cerebral metabolism in deep grey matter areas of progressive multiple sclerosis subjects – preliminary results},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5280.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Andrea Horvath and Ian Tagge and Manoj Sammi and Katherine Powers and Dennis Bourdette and Xin Li and Rebecca Spain and Charles Springer and William Rooney},
abstract={Mitochondrial injury and impaired metabolic capacity are hypothesized to drive neurodegeneration in multiple sclerosis (MS). Here, we investigate a novel putative marker of tissue metabolic activity, trans-capillary water flux, derived from dynamic contrast enhanced MRI. In this study we compared 23 subjects with progressive MS to 19 healthy controls. We find significantly reduced measures on capillary water flux in MS thalami compared to controls. Implications for use of this new biomarker are discussed.}
}
@inproceedings{ISMRM2018_5281,
annote={ISMRM2018_5281},
pages={5281},
file={ISMRM2018_5281.pdf:ISMRM2018_5281.pdf:PDF},
title={Mismatch Between Cerebral Glucose and Oxygen Metabolisms in Young Adults with Relapsing-Remitting Multiple Sclerosis},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5281.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Xiang He and Kenneth T Wengler and Elizabeth Bartlett and Leigh Charvet and Tim Q Duong and Christine DeLorenzo and Lauren Krupp},
abstract={Oxidative stress has been linked to neuroinflammation that leads to demyelination in multiple sclerosis (MS). While most studies focus on older MS patients, the underlying cause of oxidative stress at this stage of the disease may be obscured. In this study, cerebral metabolic rates of oxygen and glucose in young adult relapsing-remitting MS patients were measured with simultaneous PET/MRI. Several brain regions, most associated with the corticostriatal pathway, exhibited increased oxygen metabolism and decreased glucose metabolism in young MS patients when compared to healthy controls. These observations may elucidate the mechanism for mitochondrial dysfunction and neuroinflammation in MS pathophysiology.}
}
@inproceedings{ISMRM2018_5282,
annote={ISMRM2018_5282},
pages={5282},
file={ISMRM2018_5282.pdf:ISMRM2018_5282.pdf:PDF},
title={Altered Hippocampal {GABA} and Glutamate Levels and Uncoupling from Functional Connectivity in Multiple Sclerosis},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5282.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={fei gao and xuntao yin and weibo chen and guangbin wang},
abstract={This study offers a novel combination of methods investigating the complex relationships among excitatory/inhibitory neurotransmitters, brain connectivity and cognitive function in health and disease states. Modulation of Glu and GABA neurotransmission may enable the development of new therapeutic strategies for the early stages of MS.}
}
@inproceedings{ISMRM2018_5283,
annote={ISMRM2018_5283},
pages={5283},
file={ISMRM2018_5283.pdf:ISMRM2018_5283.pdf:PDF},
title={Quantification of white matter tract integrity in primary-progressive multiple sclerosis},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5283.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Maria Petracca and Simona Schiavi and Catarina Saiote and Lazar Fleysher and Matilde Inglese},
abstract={Diffuse white matter (WM) injury is prominent in primary progressive multiple sclerosis (PPMS). Diffusion Kurtosis Imaging (DKI) allows the quantification of non-Gaussian water diffusion, offering the possibility of more detailed characterization of WM damage, in comparison with that provided by diffusion tensor imaging metrics. Here we present application of DKI metrics in PPMS using a Tract-Based Spatial Statistics approach. We observed a diffuse WM microstructural damage, manifested as axonal water fraction, mean kurtosis and fractional anisotropy decrease. In line with histopathological studies, our results suggest the prevalence of axonal damage over demyelination in progressive MS.}
}
@inproceedings{ISMRM2018_5284,
annote={ISMRM2018_5284},
pages={5284},
file={ISMRM2018_5284.pdf:ISMRM2018_5284.pdf:PDF},
title={Multi-dimensional microstructural imaging offers novel in vivo insights into brain pathology: an application to multiple sclerosis},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5284.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Kasper Winther Andersen and Samo Lasič and Henrik Lundell and Markus Nilsson and Daniel Topgaard and Filip Szczepankiewicz and Lars G. Hanson and Hartwig Roman Siebner and Morten Blinkenberg and Tim B. Dyrby},
abstract={Magnetic resonance imaging is today the most versatile imaging method for characterization of multiple sclerosis (MS) in vivo, but clinical examinations lack sensitivity to capture changes in the tissue microstructure. Using a multi-dimensional microstructural imaging approach, we demonstrate how it is possible to obtain more specific and broader microstructural insights about the underlying pathology of MS. For this we use a comprehensive battery of conventional and novel diffusion weighted imaging and quantitative MRI sequences each capable of explaining different and complementary microstructural properties. This allows us to explore the underlying pathology of MS, which is normally only accessible with histology.}
}
@inproceedings{ISMRM2018_5285,
annote={ISMRM2018_5285},
pages={5285},
file={ISMRM2018_5285.pdf:ISMRM2018_5285.pdf:PDF},
title={Does the presence of diffusely abnormal white matter in {MS} affect cognitive function?},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5285.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={James Cairns and Irene Vavasour and Guojun Zhao and Roger Tam and Sarah Morrow and Andrew Riddehough and Alex MacKay and Anthony Traboulsee and Martin McKeown and Wayne Moore and David Li and Cornelia Laule},
abstract={Multiple sclerosis (MS) subjects with diffusely abnormal white matter (DAWM) typically progress faster on physical disability scores. The impact of DAWM on cognitive measures is unknown. 50 MS participants had conventional MRI and cognitive tests of Trails Making Test, Working Memory and Processing Speed. The presence of DAWM was not associated with worse cognitive performance. As DAWM is most commonly present in posterior regions of the brain, it may be that these cognitive tests were not sensitive to DAWM-associated pathology.}
}
@inproceedings{ISMRM2018_5286,
annote={ISMRM2018_5286},
pages={5286},
file={ISMRM2018_5286.pdf:ISMRM2018_5286.pdf:PDF},
title={Advanced diffusion {MRI} characterization of microstructure changes associated with increasing T1 hypointensity in the white matter lesions of relapsing-remitting multiple sclerosis patients.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5286.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Timothy M. Shepherd and Benjamin Ades-aron and Bettina Conti and Yvonne Lui and Dmitry S Novikov and Els Fieremans},
abstract={Autopsy studies of white matter lesions in relapsing-remitting multiple sclerosis demonstrate that FLAIR-bright lesions represent a juxtaposition of inflammation, demyelination, axonal injury and gliosis, whereas T1 hypointense lesions represent more severe confluent injury and axonal loss. We used a white matter tract integrity (WMTI) previously validated in cuprizone animal models of demyelination to better characterize specific in vivo microstructure changes associated with graded T1 signal intensity changes in multiple sclerosis lesions.}
}
@inproceedings{ISMRM2018_5287,
annote={ISMRM2018_5287},
pages={5287},
file={ISMRM2018_5287.pdf:ISMRM2018_5287.pdf:PDF},
title={{DTI} Analysis in {FLAIR}-positive Lesions and Normal-Appearing White Matter in Young Adult Multiple Sclerosis Patients},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5287.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Tao Wang and Sindhuja Govindarajan and M. Andrea Parra and Patricia Stefancin and Andrew Labella and Kenneth Wengler and Chuan Huang and Xiang He and Leigh Charvet and Lauren Krupp and Tim Q Duong},
abstract={
Neuroimaging studies showed that there is abundant diffusion tensor imaging (DTI) research that has been done on older multiple sclerosis (MS) patients. By contrast, similar research is relatively sparse in young/pediatric MS patients. Our study is interested in discovering the effects of MS on young adult patients to see whether the same pattern as in older patients appears. Our results suggest that DTI diffusivity data provides insights in the pathophysiology of MS in young adults. Diffusivity data may serve as an imaging biomarker of early disease pathophysiology in MS. }
}
@inproceedings{ISMRM2018_5288,
annote={ISMRM2018_5288},
pages={5288},
file={ISMRM2018_5288.pdf:ISMRM2018_5288.pdf:PDF},
title={Utility of Combination Image of T2-weighted and {FLAIR} using Synthetic {MRI} for Improved Lesion Contrast in Multiple Sclerosis},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5288.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yasuhiro Fujiwara and Yumi Inoue and Masayuki Kanamoto and Shota Ishida and Toshiki Adachi and Hirohiko Kimura},
abstract={To improve multiple sclerosis plaque, we attempted to produce Synthetic FLAIR3 (SyFLAIR3) combined from FLAIR and T2WI using Synthetic MRI. The purpose of this study was to determine optimal contrast weighting for SyFLAIR3 and to evaluate whether the SyFLAIR3 can improve the T2 contrast on WM. To effectively suppress CSF signal for SyFLAIR3, it was necessary to optimize the combination of TE for T2WI and FLAIR. The optimized SyFLAIR3 using Synthetic MRI makes it possible to improve contrast in MS lesion.}
}
@inproceedings{ISMRM2018_5289,
annote={ISMRM2018_5289},
pages={5289},
file={ISMRM2018_5289.pdf:ISMRM2018_5289.pdf:PDF},
title={Accelerated Isotropic Sub-Millimeter Whole-Brain Susceptibility Imaging at 3T: Application to Multiple Sclerosis},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5289.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Sunil Patil and Henrik Odéen and J. Andrew Derbyshire and Gunnar Krueger and Dennis L. Parker and Himanshu Bhat and Daniel S. Reich and Pascal Sati},
abstract={High-resolution susceptibility-weighted MRI has recently gained attention as a novel imaging biomarker in multiple sclerosis (MS) such as the ‘central vein sign’ and ‘phase rims’. This preliminary study demonstrates the feasibility of an accelerated volumetric (3D) segmented echo-planar-imaging (EPI) sequence, which allows acquiring whole brain images at 0.65 mm isotropic resolution in approximately 3 minutes. Both magnitude (T2
*-weighted) and phase (QSM) information were interpretable and displayed characteristic features of MS lesions. This accelerated 3D EPI anatomical acquisition shows potential to open the door to routine high-resolution susceptibility-weighted imaging to better support diagnosis and therapy monitoring in MS patients.}
}
@inproceedings{ISMRM2018_5290,
annote={ISMRM2018_5290},
pages={5290},
file={ISMRM2018_5290.pdf:ISMRM2018_5290.pdf:PDF},
title={Quantitative {MT} (q{MT}) imaging of the Whole Brain: Conventional 3D {MT} vs. 3D {EP}-vf{MT} methods},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5290.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Se-Hong Oh and Dongmyung Shin and Ken Sakaie and Daniel Ontaneda and Mark J. Lowe},
abstract={In this study, the whole brain qMT map from conventional MT imaging was compared with that from a newly proposed method, Segmented EPI readout Variable Flip angle Magnetization Transfer (EP-vfMT). The voxel-wise correlation shows a high correlation between the two maps. Compared to the conventional MT method, EP-vfMT provides similar image quality with good reproducibility. It also covers a whole brain volume in a much reduced scan time.}
}
@inproceedings{ISMRM2018_5291,
annote={ISMRM2018_5291},
pages={5291},
file={ISMRM2018_5291.pdf:ISMRM2018_5291.pdf:PDF},
title={Multicenter assessment of focal and diffuse cervical cord {MTR} abnormalities in early relapsing-remitting multiple sclerosis},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5291.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Benoit Combès and Anne Kerbrat and Laureline Monteau and Jean-Christophe Ferré and Emmanuelle Le Page and Josefina Maranzano and Virginie Callot and Pierre Labauge and Xavier Ayrignac and Clarisse Carra Dallière and Nicolas Menjot de Champfleur and Jean Pelletier and Adil Maarouf and David Brassat and Jérome de Seze and Nicolas Collongues and Francoise Durand Dubief and Christian Barillot and Gilles Edan and Elise Bannier},
abstract={The purpose of this work was to assess the ability of magnetization transfer ratio imaging of the cervical spinal cord to capture relevant differences in the first stage of multiple sclerosis in a multicenter context. For this purpose, we analyzed the MTR values in the lesions, the whole cord and normal-appearing cord from 52 patients in the first 18 months of the disease and from 17 controls. Images were acquired in 5 centers. We showed such measurements were able to capture relevant group differences and displayed slightly higher correlations with patients clinical status than lesion volume.}
}
@inproceedings{ISMRM2018_5292,
annote={ISMRM2018_5292},
pages={5292},
file={ISMRM2018_5292.pdf:ISMRM2018_5292.pdf:PDF},
title={Assessing the Role of Cord Atrophy Toward Disease Progression in Multiple Sclerosis},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5292.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Govind Nair and Shila Azodi and Yoshimi Akahata and Daniel S Reich and Steven Jacobson},
abstract={Plot of spinal cord cross-sectional area (SCCSA) from C1 to T10 reveals distinct patterns in various multiple sclerosis subtypes. While the relapsing remitting subtype revealed thinner cord in the cervical region, progressive subtypes had thinner c- and t-spines compared to healthy subjects. SCCSA measures were related to clinical outcomes and revealed that up to 10-15\% of disability can be explained by differences in SCCSA alone. Furthermore, segregating patients based on the SCCSA seems to give a better stratification of their clinical disability. This study suggests SCCSA can be used as an outcome measure in clinical trials.}
}
@inproceedings{ISMRM2018_5293,
annote={ISMRM2018_5293},
pages={5293},
file={ISMRM2018_5293.pdf:ISMRM2018_5293.pdf:PDF},
title={A fully unsupervised method for spinal cord lesion segmentation in Multiple Sclerosis},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5293.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Carole Hélène Sudre and Ferran Prados and Rosanna Cortese and Marios Yiannakas and Hugh Kearney and Olga Ciccarelli and Sébastien Ourselin and Claudia Angela Gandini Wheeler-Kingshott and M. Jorge Cardoso},
abstract={The presence of focal lesions in the spinal cord is an important diagnostic criteria for Multiple Sclerosis (MS). Accurate estimation of lesion volume is important for monitoring disease progression over time. However, manual and automated lesion segmentation for volume estimation remain challenging, since they rely respectively on the skills of the rater or on the automated criteria set within the algorithms. In this work, we present an adaptation to the spinal cord, of a fully unsupervised hierarchical model selection framework that automatically detects abnormality tissue patterns without any a priori knowledge on pathology location.}
}
@inproceedings{ISMRM2018_5294,
annote={ISMRM2018_5294},
pages={5294},
file={ISMRM2018_5294.pdf:ISMRM2018_5294.pdf:PDF},
title={Relationship of spinal cord volume, total and regional brain volumes to disability in a large cohort of multiple sclerosis patients},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5294.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Michaela Andelova and Jan Krasensky and Lukas Sobisek and Zdenek Seidl and Eliska Kusova and Tomas Uher and Eva Havrdova and Barbora Benova and Bénédicte Maréchal and Tobias Kober and Dana Horakova and Manuela Vaneckova},
abstract={Identification of MRI biomarkers that predict permanent neurological disability in multiple sclerosis is crucial for assigning patients to correct treatment and for appropriate recruitment of patients for clinical trials. A variety of brain structures and spinal cord have been investigated; however, neither a single structure nor combinations of structures have been routinely used as stable, specific and sensitive biomarkers. Small sample sizes, different MR protocols and segmentation approaches across studies may hamper the identification of such a biomarker. We evaluated global and regional brain volumes and cervical spinal cord volume in a large single-center cohort of multiple sclerosis patients.
}
}
@inproceedings{ISMRM2018_5295,
annote={ISMRM2018_5295},
pages={5295},
file={ISMRM2018_5295.pdf:ISMRM2018_5295.pdf:PDF},
title={Hypersynchronicity in the default mode-like network and altered {NMDA} receptor function in a maternal immune activation model},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5295.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Stephan Missault and Cynthia Anckaerts and Soumaya Ahmadoun and Ines Blockx and Kenny Bielen and Disha Shah and Samir Kumar-Singh and Annemie Van der Linden and Stefanie Dedeurwaerdere and Marleen Verhoye},
abstract={Maternal immune activation (MIA) is an important risk factor for schizophrenia, which supports the neurodevelopmental hypothesis of this disorder. Two major hypotheses of schizophrenia are the aberrant connectivity hypothesis and the NMDA receptor hypofunction hypothesis. The goal of our study was to investigate functional and structural connectivity, as well as NMDA receptor function in a MIA model using resting-state functional MRI, diffusion tensor imaging and pharmacological MRI. We observed increased functional connectivity in the default mode-like network, as well as a decreased response to the NMDA receptor antagonist in adult rats that were exposed to prenatal immune challenge.}
}
@inproceedings{ISMRM2018_5296,
annote={ISMRM2018_5296},
pages={5296},
file={ISMRM2018_5296.pdf:ISMRM2018_5296.pdf:PDF},
title={Brain Metabolism in Schizophrenia and First-Degree Relatives: a 7T {MRS} study},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5296.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Anna Min Wang and Subechhya Pradhan and Stephanie Korenic and S. Andrea Wijtenburg and Laura M. Rowland and Peter B. Barker},
abstract={Brain metabolism was investigated in 38 patients with schizophrenia (SZ), 38 healthy control (HC) subjects and 11 first degree relatives of SZ patients using 7T MRS in 5 brain regions. Multiple metabolic abnormalities were found in SZ patients, including increases in the ratio of glutamine to glutamate, increased levels of brain lactate and decreased levels of γ-aminobuytric acid (GABA) and N-acetylaspartate-glutamate (NAAG). Many of these changes also correlated with measures of cognitive performance and negative symptom severity. 7T MRS is an excellent tool for the non-invasive investigation of brain pathophysiology in SZ.}
}
@inproceedings{ISMRM2018_5297,
annote={ISMRM2018_5297},
pages={5297},
file={ISMRM2018_5297.pdf:ISMRM2018_5297.pdf:PDF},
title={Ex-vivo diffusion {MRI} reveals microstructural alterations in stress-sensitive brain regions: A chronic mild stress recovery study},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5297.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ahmad Raza Khan and Brian Hansen and Ove Wiborg and Christopher D Kroenke and Sune Nørhøj Jespersen},
abstract={Depression is a leading cause of disability worldwide and causes significant microstructural alterations in stress-sensitive brain regions. However, the potential recovery of these microstructural alterations has not previously been investigated, which we, therefore, set out to do using diffusion MRI (d-MRI) in the chronic mild stress (CMS) rat model of depression. This study reveals significant microstructural alterations after 8 weeks of recovery, in the opposite direction to change induced by stress in the acute phase of the experiment. Such findings may be useful in the prognosis of depression or for monitoring treatment response.}
}
@inproceedings{ISMRM2018_5298,
annote={ISMRM2018_5298},
pages={5298},
file={ISMRM2018_5298.pdf:ISMRM2018_5298.pdf:PDF},
title={Analysis of resting-state networks alterations of first-episode obsessive–compulsive disorder by {ICA} -based f{MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5298.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Junhong Liu and Dandan Zheng and Jingliang Cheng},
abstract={Whole brain resting-state functional connectivity was analyzed using independent component analysis in 47 subjects including 23 first-episode and treatment-naïve patients with obsessive-compulsive disorder(OCD) and 24 health controls. Three abnormal resting-state networks, pDMN, RFP and lVN, have been found in OCD patients. In addition, OCD patients showed increased functional connection in Bilateral cuneus(T=3.8222,P=0.005), Right inferior parietal lobule(T=5.291,P=0.005)and Right middle occipital lobule(T=4.614,P=0.005) compared with controls. It’s considered that changes of abnormal resting-state networks might be associated with emotional and cognitive dysfunction in OCD patients.}
}
@inproceedings{ISMRM2018_5299,
annote={ISMRM2018_5299},
pages={5299},
file={ISMRM2018_5299.pdf:ISMRM2018_5299.pdf:PDF},
title={Disrupted reward and cognitive control networks contribute to anhedonia in depression},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5299.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Liang Gong and Chunming Xie and Hongxing Zhang and Zhijun Zhang},
abstract={In the present study, we investigate the association between intrinsic reward network (β-network) and cognitive control network (δ-network) and anhedonia in depression patient. We found that depression patients showed decreased functional connectivity (FC) in intra- and inter- β- and δ-networks and the FC in both β- and δ-networks were significantly correlated with anhedonic severity in depression patients. Importantly, the integrated neural features of β- and δ-networks would more precisely predict anhedonia symptom. These findings indicated that the neural features in both β- and δ-networks would represent a fundamental mechanism underlying anhedonia in the MDD patients.}
}
@inproceedings{ISMRM2018_5300,
annote={ISMRM2018_5300},
pages={5300},
file={ISMRM2018_5300.pdf:ISMRM2018_5300.pdf:PDF},
title={Subcortical and medial temporal lobe shape changes following electroconvulsive therapy},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5300.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Filip Bouckaert and Jurgen Germann and Mallar Chakravarty and Annemieke Dols and François-Laurent De Winter and Lies Van Assche and Jan Van den Stock and Stefan Sunaert and Max Stek and Pascal Sienaert and Mathieu Vandenbulcke and Louise Emsell},
abstract={Electroconvulsive therapy is a safe, rapid-acting antidepressant treatment that has consistently been associated with grey matter (GM) volume increase, primarily in the medial temporal lobe (MTL). Here we replicate and extend previous studies by demonstrating substantial surface area and local displacement changes in subcortical and MTL GM one week following the last ECT treatment in 70 patients with late-life depression. We report new data on ECT induced thalamus shape changes and demonstrate that whilst the number of ECT treatments correlates positively with the degree of medial temporal GM surface area increase, this is not associated with clinical improvement in mood.}
}
@inproceedings{ISMRM2018_5301,
annote={ISMRM2018_5301},
pages={5301},
file={ISMRM2018_5301.pdf:ISMRM2018_5301.pdf:PDF},
title={Reduced White Matter Integrity Related with Elevated Inflammatory Cytokine Expression and Cognitive Impairments in First-episode Schizophrenia: A Diffusion Tensor Imaging Study Based on Tract-Based Spatial Statistics},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5301.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jie Gao and Yajuan Fan and Lei Wang and Yarong Wang and Feng Zhu and Min Tang and Dongsheng Zhang and Xia Zhe and Xuejiao Yan and Xin Zhang and Zhizheng Zhuo and Xiaoling Zhang},
abstract={This study aimed to investigate whether elevated inflammatory cytokine expression induced white matter integrity changes and cognitive impairments in first-episode schizophrenia patients. 27 first-episode schizophrenia patients and 16 healthy controls who underwent diffusion tensor imaging were enrolled. Tract-based spatial statistics analysis exhibited significantly decreased fractional anisotropy and increased radial diffusivity in widespread white matter tracts in patients. Of these tracts, anterior corona radiata (ACR), superior corona radiata, superior longitudinal fasciculus, the body of the corpus callosum, the splenium of the corpus callosum and fornix showed significant correlations with higher inflammatory cytokine expression. Moreover, ACR and fornix simultaneously showed reduced white matter integrity related to cognitive impairments in working memory and problem solving. These findings provides more evidence for supporting the role of neuroinflammation in the pathophysiology of schizophrenia.}
}
@inproceedings{ISMRM2018_5302,
annote={ISMRM2018_5302},
pages={5302},
file={ISMRM2018_5302.pdf:ISMRM2018_5302.pdf:PDF},
title={Disrupted functional connectivity of occipital lobe with frontal and parietal regions in subjects with Cocaine addiction.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5302.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jaspreet Kaur and Divya Gautam and Rahul Garg},
abstract={The study aims at exploring a data driven method to analyse connectivity differences between two populations - subjects with cocaine addiction and healthy controls. Sufficient indications of previously undiscovered hypo- and hyper-connectivity was observed in cocaine addicts spanning different lobes of brain suggesting that hypothesis driven approaches are insufficient.}
}
@inproceedings{ISMRM2018_5303,
annote={ISMRM2018_5303},
pages={5303},
file={ISMRM2018_5303.pdf:ISMRM2018_5303.pdf:PDF},
title={Investigation of Schizophrenia Patients with Clozapine-Induced Obsessive Compulsive Symptoms by Advanced {MR} Imaging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5303.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Arzu Ceylan Has and Sule Bicakci and Elif Bulut and Aygun Ertugrul and Kader K. Oguz},
abstract={We aimed to investigate white matter (WM) integrity and structural differences in schizophrenia patients with clozapine-induced obsessive compulsive symptoms (S-OCS) comparing them those without symptoms (S) and healthy controls (HC). Tract-based-spatial-statistic/diffusion-tensor-imaging, voxel-based morphometry and caudate volume measurements were performed to reveal underlying WM and gray matter (GM) alterations. S-OCS showed less fractional anisotropy (FA) reductions in WM and less areas of reduced GM density than S when compared to HC. FA elevations and increased GM density were observed in S-OCS compared with S. The results may suggest differential effect of clozapine and/or different baseline pathophysiology in a subgroup of patients.}
}
@inproceedings{ISMRM2018_5304,
annote={ISMRM2018_5304},
pages={5304},
file={ISMRM2018_5304.pdf:ISMRM2018_5304.pdf:PDF},
title={Whole brain effect of real-time f{MRI} amygdala neurofeedback emotional training and its association with {PTSD} symptom reduction},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5304.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Masaya Misaki and Vadim Zotev and Raquel Phillips and Chung-Ki Wong and Brent Wurfel and Frank Krueger and Matthew Feldner and Jerzy Bodurka},
abstract={
The effect of real-time fMRI neurofeedback (rtfMRI-nf) training with the left amygdala activity on whole brain regions and their association with symptom reduction was investigated in veterans with combat-related PTSD. The main effect of training was seen in the salience network regions including anterior insula and the anterior cingulate cortex (ACC). The decrease in ACC response was significantly correlated with a decrease in PTSD symptoms. These results indicated that the effect of rtfMRI-nf training was not limited to the left amygdala but other emotion-related regions were co-modulated during the training. The treatment response could be meditated by those regions.}
}
@inproceedings{ISMRM2018_5305,
annote={ISMRM2018_5305},
pages={5305},
file={ISMRM2018_5305.pdf:ISMRM2018_5305.pdf:PDF},
title={Multivariate pattern analysis of {DTI} reveals differential white matter in depressive patients with and without suicidal ideation.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5305.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Huawei Zhang and Zhiyun Jia},
abstract={At present there are no objective biological markers that can be used to reliably identify depressive individuals with and without suicidal ideation (SI). DTI data were obtained from 20 depressive patients with SI and 20 depressive patients without SI, scanned using a 3T MRI system. Fractional anisotropy (FA) values of white matter between patients were examined using multivariate support vector machine (SVM). SVM applied to FA images correctly discriminated two groups of patients with a sensitivity of 75\% and a specificity of 85\% resulting in a statistically significant accuracy of 80\% (p≤0.001). The discriminating regions contain the bilateral occipital lobes and parietal lobes, right temporal lobe and splenium of corpus callosum. These results reveal patterns of neuroanatomical alterations that could be used to inform the identification of depressive patients with and without SI at the individual level.}
}
@inproceedings{ISMRM2018_5306,
annote={ISMRM2018_5306},
pages={5306},
file={ISMRM2018_5306.pdf:ISMRM2018_5306.pdf:PDF},
title={{EEG} Correlates of Real-time f{MRI} Neurofeedback of the Amygdala in Combat-related {PTSD} Evaluated Using e{LORETA}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5306.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Vadim Zotev and Raquel Phillips and Masaya Misaki and Chung Ki Wong and Brent Wurfel and Matthew Meyer and Frank Krueger and Matthew Feldner and Jerzy Bodurka},
abstract={We have performed a study of emotion regulation training in veterans with combat-related PTSD using real-time fMRI neurofeedback (rtfMRI-nf) with simultaneous EEG. Eighteen PTSD patients learned to upregulate their left amygdala activity using rtfMRI-nf during a positive emotion induction task based on retrieval of happy autobiographical memories. EEG source analysis with eLORETA revealed task-specific changes in the current source densities in the upper alpha and delta EEG bands that significantly correlated with PTSD severity. These results suggest that the rtfMRI-nf training in combination with EEG source analysis provides new insights into the neurobiology of PTSD.}
}
@inproceedings{ISMRM2018_5307,
annote={ISMRM2018_5307},
pages={5307},
file={ISMRM2018_5307.pdf:ISMRM2018_5307.pdf:PDF},
title={Multimodal metabolic imaging using single voxel {MRS} and [11C]{ABP}688 {PET} in Schizophrenic Patients},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5307.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Linda Orth and Ravichandran Rajkumar and Cláudia Régio Brambilla and Ezequiel Farrher and Andreas Matusch and Shukti Ramkiran and Andrej Ruch and Jörg Mauler and Elena Rota Kops and Lutz Tellmann and Jürgen Scheins and Bernd Neumaier and Markus Lang and Johannes Ermert and Hans Herzog and Karl-Josef Langen and Christoph Lerche and N. Jon Shah and Irene Neuner},
abstract={By utilizing a multimodal imaging approach, the levels of glutamate and other metabolites in the anterior cingulate and the posterior cingulate cortex were assessed by MRS and compared to the metabotropic glutamate receptor 5 (mGluR5) binding potential using [11C]ABP688 PET in schizophrenic patients and healthy controls. Glutamate levels seem to be elevated in schizophrenic patients. PET analysis revealed no differences in binding potential (BPND) in both diagnostic groups. However, adding smoking status to analysis, there is a significant reduction in BPND in smokers compared to non-smokers, suggesting a connection between mGluR5 binding potential and nicotine dependence.}
}
@inproceedings{ISMRM2018_5308,
annote={ISMRM2018_5308},
pages={5308},
file={ISMRM2018_5308.pdf:ISMRM2018_5308.pdf:PDF},
title={A multi-methodological f{MRI} resting state voxel-wise analysis to assess brain abnormalities of children with {ADHD}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5308.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yingxue Gao and Hailong Li and Xuan Bu and Lianqing Zhang and Xinyu Hu and Peiran Hu and Xiaoxiao Hu and Xiaoqi Huang},
abstract={We used three different measurements including regional homogeneity (ReHo), voxel-mirrored homotopic connectivity (VMHC) and functional connectivity strength (FCS) to explore local and interhemispheric FC in drug naïve ADHD children. And we found lower ReHo and FCS in ADHD located in almost identical region of right middle frontal gyrus and correlated with each other. In addition, we also found lower VMHC in the bilateral occipital lobe, which was related with characteristics of WCST and CPRS-R. This finding may provide new insights into functional connectivity changes in ADHD and promote the exploration of functional network in the future.}
}
@inproceedings{ISMRM2018_5309,
annote={ISMRM2018_5309},
pages={5309},
file={ISMRM2018_5309.pdf:ISMRM2018_5309.pdf:PDF},
title={Quantative Tractography Reveals Alteration in Corticospinal Tract Associated with Motor Abnormalies in Medication-Naive Attention-Deficit /Hyperactivity Disorder Children},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5309.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Xuan Bu and Qingxia Lin and Lu Lu and Lianqing Zhang and Xiaoxiao Hu and Hailong Li and Xinyu Hu and Chuang Yang and Xiaoqi Huang},
abstract={In the current study, we aim to quantify diffusion measures at multiple nodes along the trajectory of corticospinal tract in ADHD children. We found altered FA and RD in distinctive CST regions. Besides, significant correlations between neuropsychological measurements and abnormal white matter microstructure implicated critical role the disturbed CST played in the pathology of motor deficits in ADHD.}
}
@inproceedings{ISMRM2018_5310,
annote={ISMRM2018_5310},
pages={5310},
file={ISMRM2018_5310.pdf:ISMRM2018_5310.pdf:PDF},
title={The effects of relapse on gray matter volume changes in patients with Major Depression – a longitudinal {VBM} study},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5310.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Harald Kugel and Dario Zaremba and Katharina Dohm and Ronny Redlich and Dominik Grotegerd and Robert Strojny and Susanne Meinert and Christian Buerger and Verena Enneking and Katharina Foerster and Jonathan Repple and Nils Opel and Bernhard T Baune and Pienie Zwitserlood and Walter Heindel and Volker Arolt and Udo Dannlowski},
abstract={Structural brain alterations in major depressive disorder (MDD) are associated with patients' course of illness, especially in progressive and recurrent MDD. Here, a longitudinal study investigated the influence of relapse on gray matter volume. As a result, Voxel based morphometry showed a decrease of insular and DLPF gray matter volume in patients with at least one relapse, while volume in patients without relapse was stable. This illustrates the negative effect of relapse on structural brain alterations.}
}
@inproceedings{ISMRM2018_5311,
annote={ISMRM2018_5311},
pages={5311},
file={ISMRM2018_5311.pdf:ISMRM2018_5311.pdf:PDF},
title={Characteristic Changes of Shape in Subcortical Nuclei in Major Depressive Disorder},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5311.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Lianqing Zhang and Naici Liu and Lu Li and Lu Lu and Xiaoxiao Hu and Hailong Li and Xuan Bu and Xinyu Hu and Qiyong Gong and Xiaoqi Huang},
abstract={We analysis alterations of volume and shape of subcortical nuclei in a relatively large sample of adult patients with Major Depressive Disorder (MDD) using an automatically segmentation and vertex-based shape analysis protocol. We found that hippocampus, putamen and accumbens were impaired in patients with MDD and subregional shape of hippocampus, accumbens and pallidum may have potential predictive value of treatment response in patients with MDD. Shape analysis may provide more evidence of neuropathology related to depression from a different perspective. Future study should consider shape and volume analysis simultaneously.}
}
@inproceedings{ISMRM2018_5312,
annote={ISMRM2018_5312},
pages={5312},
file={ISMRM2018_5312.pdf:ISMRM2018_5312.pdf:PDF},
title={Alterations in functional brain network topology in Tourette’s syndrome},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5312.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Shukti Ramkiran and Larissa Heidemeyer and Ravichandran Rajkumar and N Jon Shah and Irene Neuner},
abstract={Tourette syndrome (TS) is a neurodevelopmental disorder with typical onset in childhood. Its characteristic motor tics are said to be attributed to dysfunction in the cortico-striato-thalamo-cortical circuit and cerebellar communication. Brain functional connectivity along with network topology analysis provides a useful tool to understand communication strategies in the brain. Hence we aim to investigate alterations in functional and effective connectivity in brains of patients with TS. Based on prior results1,2, we hypothesize that connectivity of basal ganglia, thalamus and cerebellum with other regions will be altered.}
}
@inproceedings{ISMRM2018_5313,
annote={ISMRM2018_5313},
pages={5313},
file={ISMRM2018_5313.pdf:ISMRM2018_5313.pdf:PDF},
title={Altered Brain Activity in Jet Lag by Regional Homogeneity (ReHo): A resting state f{MRI} study},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5313.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Feifei Zhang and Zhiyun Jia and Qiyong Gong},
abstract={To identify how jet lag influence brain activity in rest we calculate ReHo values of 23 adult participants who were on a transmeridian flight across eight-time zones from west to east .Participants in ‘Jet Lag’ state compare to recovered state showed decreased ReHo value in the right inferior parietal lobule (BA40, BA7) and the right angular gyrus and increased in the bilateral occipital lobe. Acute circadian disruption caused by jet lag can lead to mild temporary visual cognitive dysfunction.}
}
@inproceedings{ISMRM2018_5314,
annote={ISMRM2018_5314},
pages={5314},
file={ISMRM2018_5314.pdf:ISMRM2018_5314.pdf:PDF},
title={Meta-analytic investigations of grey matter alterations in patients with anorexia nervosa.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5314.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Simin Zhang and Weina Wang and Xiaorui Su and Qiyong Gong and Qiang yue},
abstract={The purpose of the present Meta-analytic study was to summarize the grey matter volumetric alterations and elucidate how the changes were associated with symptoms and pathophysiology in anorexia nervosa(AN). We use effect-size signed differential mapping (ES-SDM) to conduct meta-analytical whole brain volumetric differences between patients AN and healthy controls (HCs). The studies showed volume reduction in bilateral median cingulate cortex(MCC), posterior cingulate cortex (PCC), precuneus, supplementary motor area(SMA) and left cerebellum, which provide evidence for abnormalities in emotion regulation, behavior regulation and sensorimotor area in nervosa anorexia.}
}
@inproceedings{ISMRM2018_5315,
annote={ISMRM2018_5315},
pages={5315},
file={ISMRM2018_5315.pdf:ISMRM2018_5315.pdf:PDF},
title={Meta-analysis of Resting-State Functional Connectivity in Major Depressive Disorder},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5315.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Shi Tang and Xinyu Hu and Lianqing Zhang and Lu Lu and Xuan Bu and Xiaoxiao Hu and Hailong Li and Qiyong Gong and Xiaoqi Huang},
abstract={To investigate the most reliable resting-state functional connectivity(rsFC) abnormalities in adult dignosed as having major depressive disorder(MDD) with existing studies.After a comprehensive literature search of studies, meta analysis was conducted using Signed Differential Mapping(SDM) software package. We found dysfunction in large-scale brain regions in MDD patients, including hyperconnectivity in fronto-cingulate-parietal area and hypoconnectivity in bilateral superior temporal gyrus(STG). These findings paralleled to the core feature of MDD patients and may underlie the cognitive and affective abnormalities in depressive disorder.}
}
@inproceedings{ISMRM2018_5316,
annote={ISMRM2018_5316},
pages={5316},
file={ISMRM2018_5316.pdf:ISMRM2018_5316.pdf:PDF},
title={The morphometric brain alteration in current and remitted major depressive disorder: a meta-analysis},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5316.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Xin Xu and Zhiyun Jia and Qiyong Gong},
abstract={To investigate the gray matter volume (GMV) alteration in major depressive disorder (MDD) patients at different episode state, here we conducted a meta-analysis which tried to integrate the Voxel-based morphometry (VBM) studies by using Seed-based d Mapping. This study detected that lower GMV in the left insula in both current and remitted MDD patients compared to HC. And the current conjunction meta-analysis indicated that GMV in bilateral anterior cingulate (ACC) were decreased in current MDD patients but increased in remitted MDD patients. Our findings here motivate a morphological alteration pattern of MDD linked to dynamic mood dysfunction state.}
}
@inproceedings{ISMRM2018_5317,
annote={ISMRM2018_5317},
pages={5317},
file={ISMRM2018_5317.pdf:ISMRM2018_5317.pdf:PDF},
title={The effects of illness duration on white matter connectivity in drug-naive schizophrenia},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5317.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Fei Li and Su Lui and Li Yao and Wei Liao and Gongjun Ji and Xiaoqi Huang and Qiyong Gong},
abstract={This study investigated the topological alterations of white matter connectivity in schizophrenia patients with a long illness duration by using diffusion tensor imaging and graph theoretical analysis and explored the relationship of such characteristics with the duration. We recruited three groups including the healthy controls, drug-naive schizophrenia patients with a short illness duration (0.1 to 10 months) and a long duration (12 to 36 months) and found that only the patients with a long illness duration exhibited decreased connection strength than the controls and a correlation between the nodal degree of rolandic operculum and the duration, suggesting a neuroprogressiveprocess.}
}
@inproceedings{ISMRM2018_5318,
annote={ISMRM2018_5318},
pages={5318},
file={ISMRM2018_5318.pdf:ISMRM2018_5318.pdf:PDF},
title={Functional Connectivity as a Potential Predictor of Treatment Response in Patients With Major Depressive Disorder},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5318.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Hailong Li and Xinyu Hu and Lianqing Zhang and Lu Lu and Xiaoxiao Hu and Xuan Bu and Shi Tang and Qiyong Gong and Xiaoqi Huang},
abstract={Resting-state functional connectivity(FC) analyses using a subcallosal cingulate cortex(SCC) seed was applied to major depressive disorder(MDD) patients to characterize a potential neuro-imaging biomarker that identifies the treatment outcome. MDD patients were divided into refractory and non-refractory group according to the treatment response. We found distinguished FC alterations between the three groups especially the lack of FC between SCC and Anterior Cingulate Cortex in the refractory MDD patients. In addition, the alterations in FC correlated with clinical symptoms in different ways in two MDD groups.
}
}
@inproceedings{ISMRM2018_5319,
annote={ISMRM2018_5319},
pages={5319},
file={ISMRM2018_5319.pdf:ISMRM2018_5319.pdf:PDF},
title={Distortion-free diffusion imaging with {SMS} {PROPELLER} {DUO}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5319.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ali Ersoz and Graeme C McKinnon},
abstract={Although fast spin echo based diffusion-weighted imaging methods provide distortion-free images, they suffer from prolonged scan times. In this work, we incorporated simultaneous multi-slice (SMS) techniques into PROPELLER DUO for accelerated distortion-free diffusion imaging. Results show that SMS PROPELLER DUO can reduce scan time dramatically which can make it a feasible option for clinical applications.}
}
@inproceedings{ISMRM2018_5320,
annote={ISMRM2018_5320},
pages={5320},
file={ISMRM2018_5320.pdf:ISMRM2018_5320.pdf:PDF},
title={Non-{CPMG} {PROPELLER} diffusion imaging: comparison of phase insensitive preparation with split acquisition},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5320.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Kun Zhou and Wei Liu and Shi Cheng},
abstract={Turbo spin echo (TSE) based diffusion weighted (DW) PROPELLER imaging has the advantage of reduced sensitivity to B0 inhomogeneity and T2 decay caused image blurring, comparing to DW-EPI sequence. However, the violation of CPMG condition is a challenge for DW-PROPELLER sequences. Phase insensitive preparation and split acquisition methods can be used to handle the non-CPMG problem. A comparison study of these two methods was performed and the results show that the phase insensitive method has superior image quality while split acquisition method has the advantage of speed and lower SAR.}
}
@inproceedings{ISMRM2018_5321,
annote={ISMRM2018_5321},
pages={5321},
file={ISMRM2018_5321.pdf:ISMRM2018_5321.pdf:PDF},
title={Multiband Diffusion-Weighted {MRI} of the Eye and Orbit Free of Geometric Distortions Using a {RARE}-{EPI} Hybrid},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5321.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Katharina Paul and Till Huelnhagen and Sebastian Schmitter and Oliver Stachs and Thoralf Niendorf},
abstract={This study shows that multiband diffusion-weighted RARE-EPI has the capability to acquire distortion-free images of the eye and orbit with ample diffusion contrast for slices in close proximity. The results underpin the challenges of ocular imaging at 3.0 T and 7.0 T for echo planar imaging and demonstrate that these issues can be offset by using accelerated RARE based approaches. This benefit can be exploited for the assessment of spatial arrangements of the eye segments and their masses with the goal to provide guidance in diagnostic assessment and treatment of ophthalmological diseases.}
}
@inproceedings{ISMRM2018_5322,
annote={ISMRM2018_5322},
pages={5322},
file={ISMRM2018_5322.pdf:ISMRM2018_5322.pdf:PDF},
title={Distortion-Free High-Resolution Diffusion {MRI} with {RPG}-{MUSE}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5322.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Iain P Bruce and Christopher Petty and Allen W Song},
abstract={Diffusion-weighted images acquired with multi-shot EPI at high-resolution are susceptible to inter-shot motion artifacts and geometric distortions resulting from magnetic-field inhomogeneities. This study presents an efficient means of inherently accounting for both motion and distortion artifacts by alternating the phase encoding gradient polarities in odd/even shots of multi-shot EPI. When acquired in this fashion, the proposed RPG-MUSE model simultaneously accounts for both shot-to-shot motion induced artifacts and geometric distortions during the reconstruction of multi-shot diffusion weighted images. This technique requires no additional scan time and accounts for B
0 and eddy current induced distortions specific to each diffusion-weighted volume.}
}
@inproceedings{ISMRM2018_5323,
annote={ISMRM2018_5323},
pages={5323},
file={ISMRM2018_5323.pdf:ISMRM2018_5323.pdf:PDF},
title={Diffusion-weighted {MRI} of the prostate without susceptibility artifacts: Multi-shot {STEAM} with radial undersampling},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5323.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Andreas Merrem and Klaus-Dietmar Merboldt and Jakob Klosowski and Jens Frahm},
abstract={Undersampled radial STEAM MRI allows for diffusion-weighed imaging without susceptibility artifacts. Here, this technique was developed for applications to the prostate by moving to a multi-shot acquisition and reconstruction method to optimally process data with limited SNR. Numerical simulations defined the conditions for accurate ADC measurements. In vivo studies of healthy subjects resulted in ADC values in the central gland of the prostate which are consistent and in agreement with previous literature values. A comparison of DW STEAM and DW EPI of the prostate confirmed the major benefit of STEAM sequences which are free of susceptibility-induced distortions.}
}
@inproceedings{ISMRM2018_5324,
annote={ISMRM2018_5324},
pages={5324},
file={ISMRM2018_5324.pdf:ISMRM2018_5324.pdf:PDF},
title={Improved signal-to-noise ratio with highly asymmetric {STEAM}-{EPI} ({HASTEAM}-{EPI})},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5324.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Manoj Shrestha and Ulrike Nöth and Ralf Deichmann},
abstract={Several methods exist for increasing the signal-to-noise ratio (SNR) in high spatial resolution imaging, e.g., by using reduced field-of-view techniques or reduced echo-times (TE). Here, a novel module dubbed “highly asymmetric STEAM" (HASTEAM) is proposed, where the stimulated echo (STE) occurs prior to the EPI readout and thus maintains a constant duration of STE preparation, independent of the acquisition matrix-size. This shortens TE and allows for higher SNR, in particular for high spatial resolutions. SNR gain of HASTEAM over the standard STEAM is simulated and compared to in vivo results for different resolutions in structural and diffusion-weighted imaging.}
}
@inproceedings{ISMRM2018_5325,
annote={ISMRM2018_5325},
pages={5325},
file={ISMRM2018_5325.pdf:ISMRM2018_5325.pdf:PDF},
title={Comparison of Different Methods for Motion-induced Data Corruption Detection Using k-space Information in Diffusion Imaging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5325.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Zhe Zhang and Hua Guo and Zhangxuan Hu and Yaou Liu and Yilong Wang and Chun Yuan},
abstract={In diffusion imaging, subject motion together with diffusion encoding gradient may introduce data corruption. Several methods for corrupted data detection using k-space information such as DC peak amplitude, entropy and signal distribution metric have been proposed and the detection directly from acquired k-space enables instant data rejection and re-acquisition. This work compared and evaluated these methods using the same single-shot data set. The results show that all methods can successfully detect corrupted shots and demonstrate good detection consistency with each other and also with ADC measurement.}
}
@inproceedings{ISMRM2018_5326,
annote={ISMRM2018_5326},
pages={5326},
file={ISMRM2018_5326.pdf:ISMRM2018_5326.pdf:PDF},
title={Highly efficient diffusion {MRI} by Slice-interleaved Free-waveform Imaging ({SIFI})},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5326.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jana Hutter and Markus Nilsson and Daan Christiaens and Torben Schneider and Anthony N Price and Joseph V Hajnal and Filip Szczepankiewicz},
abstract={Diffusion encoding along multiple directions in a single shot facilitates probing of tissue microstructure that is not accessible with conventional (linear) tensor encoding. However, it tends to engage gradients on multiple axes in a pattern that yields higher energy consumption, which can become a critical limiting factor for gradient system performance. Here, we show that Slice Interleaved Free-waveform Imaging (SIFI) of b-tensor size, orientation and shape reduces peak power consumption and heating, which translates to markedly reduced repetition time, shorter examination times and higher temporal SNR.}
}
@inproceedings{ISMRM2018_5327,
annote={ISMRM2018_5327},
pages={5327},
file={ISMRM2018_5327.pdf:ISMRM2018_5327.pdf:PDF},
title={Efficient mutli-slice reduced field of view cardiac T2-{ADC} mapping with a restore pulse},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5327.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Kévin Moulin and Eric Aliotta and Daniel B Ennis},
abstract={Slice-following significantly reduces the scan time in cardiac diffusion weighting imaging by enabling free-breathing acquisition compatible with multi-slice coverage. However reduced field of view techniques result in a significant SNR penalty when combined with this multi-slice strategy. The objective of this work was to develop and evaluate a reduce field of view T2+ADC protocol compatible with multi-slice acquisition by using a “restore” pulse to improve higher SNR-efficiency.}
}
@inproceedings{ISMRM2018_5328,
annote={ISMRM2018_5328},
pages={5328},
file={ISMRM2018_5328.pdf:ISMRM2018_5328.pdf:PDF},
title={Combined Crushers: Omitting Separate Crusher Gradients in the Twice-Refocused Spin Echo Diffusion {MRI} Sequence},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5328.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Richard Buschbeck and Seong Dae Yun and Markus Zimmermann and Ezequiel Farrher and N. Jon Shah},
abstract={A new method is proposed that allows for the omission of crusher gradients in the Twice-Refocused Spin Echo (TRSE) sequence. The proper spoiling of the unwanted signal pathways is achieved by modifying the amplitudes and durations of the diffusion gradients. Both the crusher moment as well as the desired diffusion weighting is eventually provided only by the diffusion gradients. This results in several advantages like shorter minimum TEs and higher SNRs, all of which can be beneficial in diffusion MRI.}
}
@inproceedings{ISMRM2018_5329,
annote={ISMRM2018_5329},
pages={5329},
file={ISMRM2018_5329.pdf:ISMRM2018_5329.pdf:PDF},
title={Flow-compensated {IVIM} model: accuracy and precision as function of {SNR}, b-values and perfusion fraction},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5329.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Susanne S. Rauh and Oliver J. Gurney-Champion and Uwe Oelfke and Frederik B. Laun and Andreas Wetscherek},
abstract={To use intravoxel incoherent motion (IVIM) modelling for clinical applications, the model parameters need to be determined accurately and precisely, which was found challenging. We studied the influence of signal-to-noise ratio (SNR), number of b-values and perfusion fraction on the accuracy of the recently introduced flow-compensated IVIM model parameters (tissue diffusivity, perfusion fraction, characteristic timescale and blood flow velocity). Simulations were performed for typical parameters obtained in healthy volunteers for pancreas and kidney and revealed that for an SNR of 20, 9 b-values and a perfusion fraction of more than 15\% are needed for reliable parameter estimation in flow-compensated IVIM.}
}
@inproceedings{ISMRM2018_5330,
annote={ISMRM2018_5330},
pages={5330},
file={ISMRM2018_5330.pdf:ISMRM2018_5330.pdf:PDF},
title={Simultaneous {IVIM} and kurtosis acquisition in brain tumours: a trace-based protocol validated in a hybrid {MR}-{PET} system},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5330.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ricardo Loução and Ana-Maria Oros-Peusquens and Karl-Josef Langen and Hugo Alexandre Ferreira and N. Jon Shah},
abstract={Diffusion weighted imaging such as intravoxel incoherent motion (IVIM) and non-Gaussian diffusion (NG-diff) allow the non-invasive study of tissue perfusion and are able to infer the organisation of the microstructure, respectively. Both are highly relevant in pathology characterisation, but are often acquired separately. Here we propose a unified IVIM/NG-diff protocol and apply it to brain tumour patients undergoing preoperative or follow-up scans in a hybrid MR-PET environment. The results agree well with previously reported values using standard techniques. Furthermore, indication for tumour grading power of IVIM parameters was found.}
}
@inproceedings{ISMRM2018_5331,
annote={ISMRM2018_5331},
pages={5331},
file={ISMRM2018_5331.pdf:ISMRM2018_5331.pdf:PDF},
title={Randomized-Slice Simultaneous Multi-Slice for Diffusion Kurtosis Imaging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5331.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Daniel V Olson and Volkan Emre Arpinar and Andrew Nencka and L. Tugan Muftuler},
abstract={Simultaneous Multi-slice (SMS) techniques excite multiple slices simultaneously to accelerate MRI data acquisition. However, slice separation during image reconstruction is not exact and results in coupling between separated voxels. While this may not be critical for most anatomic imaging methods, small but consistent leakage of information from another slice in a DKI dataset will cause bias in diffusion parameter estimates. Here, we implement a randomized-slice pairing technique to alleviate this problem in diffusion MRI acquisitions.}
}
@inproceedings{ISMRM2018_5332,
annote={ISMRM2018_5332},
pages={5332},
file={ISMRM2018_5332.pdf:ISMRM2018_5332.pdf:PDF},
title={Multi-Shot Diffusion-Weighted {EPI} Reconstruction Based on Locally Low-Rank Constraints},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5332.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Xin Ma and Mengye Lyu and Yilong Liu and Ed X. Wu},
abstract={Based on the locally low rank (LLR) property of multi-shot diffusion-weighted imaging (DWI), a novel reconstruction scheme is proposed to achieve high signal-to-noise ratio (SNR) without explicit estimation of inter-shot phase variation. The results from in vivo DWI data indicate that the proposed method can effectively improve the image quality at various shot numbers when compared with traditional shot-by-shot reconstruction approaches.}
}
@inproceedings{ISMRM2018_5333,
annote={ISMRM2018_5333},
pages={5333},
file={ISMRM2018_5333.pdf:ISMRM2018_5333.pdf:PDF},
title={{SPIR}iT-Based Reconstruction of Interleaved Multi-shot {EPI} ({SPECTRA}) for Navigator-Free Diffusion Weighted {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5333.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Gaojie Zhu and Hai Luo and Xiang Zhou and Meining Chen and Chao Wang and Wei Bian and Ziyue Wu},
abstract={Multi-shot EPI can achieve a high imaging resolution for Diffusion weighted MRI (DWI) by sampling a large k-space without increasing the degree of T2* blurring. However, its shot-to-shot phase error has to be corrected. Recently, a navigator-free correction method based on SENSE technique has been developed, assuming the phase error is spatially smooth among different DWI shots. In this work, we propose a SPIRiT-based method to correct the phase error and iteratively reconstruct navigator-free multi-shot EPI. Our results suggest it has the advantage of insensitivity to coil map bias and better SNR compared to the SENSE-based method.}
}
@inproceedings{ISMRM2018_5334,
annote={ISMRM2018_5334},
pages={5334},
file={ISMRM2018_5334.pdf:ISMRM2018_5334.pdf:PDF},
title={Eddy current characterization and correction using field monitoring for diffusion weighted imaging with maximal strength of 250 mT/m},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5334.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yi-Cheng Hsu and Ying-Hua Chu and Thomas Witzel and Qiuyun Fan and Fa-Hsuan Lin},
abstract={We used a 24-channel field probe array to characterize the eddy current in a connectome scanner during diffusion weightedimaging with the maximal strength of 250 mT/m. Image distortion can be reduced by field monitoring but noticeable artifact remained after characterizing the eddy by up the 3rd-order spherical harmonics. We also found that eddy current lasted longer than 1 s. Our results suggested that the connectome scanner is not a linear time-invariant system, where concurrent field monitoring and high-order spherical harmonics characterization are desired.}
}
@inproceedings{ISMRM2018_5335,
annote={ISMRM2018_5335},
pages={5335},
file={ISMRM2018_5335.pdf:ISMRM2018_5335.pdf:PDF},
title={The importance of constraints and spherical sampling in diffusion {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5335.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Tom Dela Haije and Aasa Feragen},
abstract={In this work we analyze the incidence of voxels with physically impossible model parameters, reconstructed from diffusion-weighted data that is acquired using different sampling schemes. Our results show that for cumulants up to order $4$ constrained least squares can be used to compute a reliable reconstruction of the cumulant expansion of the signal from realistic acquisitions, with spherical sampling producing fewer unsatisfied model constraints compared to space-filling sampling. Voxels where reconstruction is likely to fail are shown to be consistently localized near the white matter-gray matter interface and in deep brain structures.}
}
@inproceedings{ISMRM2018_5336,
annote={ISMRM2018_5336},
pages={5336},
file={ISMRM2018_5336.pdf:ISMRM2018_5336.pdf:PDF},
title={Phase Inconsistency Compensated Multi-shot Diffusion Image Reconstruction with Locally Low-Rank Constraint},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5336.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ziwu Zhou and Fei Han and Yu Gao and Yingli Yang and Peng Hu},
abstract={Multi-shot diffusion imaging is a promising technique to achieve high-resolution visualization of the microstructure of the issue. However, phase variations induced by physiological motion among different shots remains to be a challenge. To improve the reconstruction accuracy, we propose a novel reconstruction method that integrates the information of phase variation within a compressed sensing framework and exploits the data redundancy using locally low-rank constraint after phase inconsistency is taken care of.}
}
@inproceedings{ISMRM2018_5337,
annote={ISMRM2018_5337},
pages={5337},
file={ISMRM2018_5337.pdf:ISMRM2018_5337.pdf:PDF},
title={Model-Based Iterative Reconstruction for in vivo Diffusion Quantification},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5337.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jannik Marcel Arbogast and Anna-Katinka Bracher and Meinrad Beer and Henning Neubauer and Volker Rasche},
abstract={A model-based iterative reconstruction of the apparent diffusion coefficient (ADC) is introduced enabling the quantification of diffusion properties from undersampled DWI data of human knee joints. The approach uses an underlying model function to synthesize k-space data containing crucial phase information. A NLCG is implemented for ADC reconstruction comparing synthetic and measured k-space data. In vivo data of nine subjects show up to 3.5-fold acceleration of the DWI sequence without losing substantial accuracy of the ADC estimates.}
}
@inproceedings{ISMRM2018_5338,
annote={ISMRM2018_5338},
pages={5338},
file={ISMRM2018_5338.pdf:ISMRM2018_5338.pdf:PDF},
title={A {POCS}-Enhanced k-Space Reconstruction for 3D Multi-Slab Diffusion Imaging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5338.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Erpeng Dai and Xiaodong Ma and Zhe Zhang and Yu-hsuan Wu and Wenchuan Wu and Karla L. Miller and Chun Yuan and Hua Guo},
abstract={3D multi-slab acquisition is a new technique for high-resolution isotropic diffusion imaging with sufficient SNR maintained. To fill the whole 3D k-space, multi-shot acquisitions are usually needed. However, this can cause the inter-shot phase variations. In this study, we propose a new k-space-based phase correction method for multi-slab diffusion imaging. This proposed method is based on a previous method termed GRAPPA with compact kernel (GRAPPA-CK). Furthermore, POCSMUSE algorithm is subsequently used to enhance the reconstruction of GRAPPA-CK. Finally, the newly proposed method is demonstrated to be compatible with in-plane acceleration in 3D multi-slab imaging.}
}
@inproceedings{ISMRM2018_5339,
annote={ISMRM2018_5339},
pages={5339},
file={ISMRM2018_5339.pdf:ISMRM2018_5339.pdf:PDF},
title={Novel Image-based Nyquist Ghost Correction of Diffusion-Weighted Echo Planar Imaging using Ghost/Object Minimization},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5339.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jessica A McKay and Steen Moeller and Sudhir Ramanna and Edward J Auerbach and Gregory J Metzger and Justin R Ryder and Kamil Ugurbil and Essa Yacoub and Patrick J Bolan},
abstract={Diffusion weighted imaging (DWI) acquired with SE-EPI is subject to Nyquist ghosts, which are commonly corrected using a three-line navigator. However, several alternative ghost correction strategies do not require any reference acquisition. These methods define a cost function that is minimized when the image is ghost-free. We propose a novel referenceless method called ghost/object minimization by defining the cost function as the summation over the image divided by its ½-FOV-shifted counterpart. In this work, we test noise sensitivity and demonstrate the feasibility of the ghost/object minimization using simulated ghosts and in vivo acquisitions including brain, prostate, breast and liver DWI.}
}
@inproceedings{ISMRM2018_5340,
annote={ISMRM2018_5340},
pages={5340},
file={ISMRM2018_5340.pdf:ISMRM2018_5340.pdf:PDF},
title={Accelerating Intravoxel Incoherent Motion Mapping in the Brain using k-bpp {PCA}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5340.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Georg Ralph Spinner and Johannes Frieder Matthias Schmidt and Sebastian Kozerke},
abstract={Intravoxel Incoherent Motion (IVIM) parameter mapping yields quantitative information about diffusion and pseudo-perfusion properties. In brain IVIM, parallel imaging with two-fold undersampling has been reported. In order to address noise amplification and unfolding artifacts at undersampling factors greater than two with parallel imaging, reconstruction in spatio-principal component space with data reshuffling (k-b
pp PCA) is presented here. Using in-vivo brain data, it is demonstrated that k-b
pp PCA allows for significantly increased undersampling factors relative to parallel imaging while maintaining comparable image quality and parameter estimation errors.}
}
@inproceedings{ISMRM2018_5341,
annote={ISMRM2018_5341},
pages={5341},
file={ISMRM2018_5341.pdf:ISMRM2018_5341.pdf:PDF},
title={Comparison of Navigator-free Multi-shot Diffusion-Weighted Imaging Reconstruction Algorithms for {EPI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5341.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Malte Steinhoff and Kay Nehrke and Peter Börnert},
abstract={Multi-shot diffusion-weighted MRI allows for higher spatial resolution than single-shot approaches, but suffers from image artifacts due to motion-induced shot-specific phase variations. Advanced parallel imaging reconstructions can mitigate these effects, but a comparison of these approaches is still missing, especially for the widespread EPI. Following the concept of reproducible research, a number of algorithms were implemented, adapted and refined for EPI and compared in simulations and in-vivo. Results show different performance and applicability. The iterative feedback and the sharing of joint global information in the reconstruction and appropriate constraints were found to be crucial for high-quality high-resolution DWI.}
}
@inproceedings{ISMRM2018_5342,
annote={ISMRM2018_5342},
pages={5342},
file={ISMRM2018_5342.pdf:ISMRM2018_5342.pdf:PDF},
title={A diffusion-matched principal component analysis ({DM}-{PCA}) based denoising procedure for high-resolution diffusion-weighted {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5342.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Nan-kuei Chen and Hing-Chiu Chang and Ali Bilgin and Adam Bernstein and Theodore P Trouard},
abstract={A concern with high-resolution DWI and DTI is the limited SNR. Here we report a new denoising procedure, termed diffusion-matched principal component analysis (DM-PCA), which comprises 1) identifying a group of voxels with very similar signal variation patterns along the diffusion dimension, 2) performing PCA along the diffusion dimension for those voxels and 3) suppressing noisy PCA components. The DM-PCA method performs reliably for input data with a range of SNR and different numbers of diffusion encoding scans, without compromising anatomic resolvability and should prove highly valuable for imaging studies in research and clinical uses.
}
}
@inproceedings{ISMRM2018_5343,
annote={ISMRM2018_5343},
pages={5343},
file={ISMRM2018_5343.pdf:ISMRM2018_5343.pdf:PDF},
title={A framework for b-value optimization in {DWI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5343.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Rick Keesman and Leon ter Beek and Uulke van der Heide},
abstract={Diffusion-weighted imaging is a valuable asset in the diagnosis of a plethora of diseases. General guidelines are available when measuring (mono-exponential) diffusion in several organs of interest, but there is less consensus on optimal acquisition parameters for more complex models (e.g., intravoxel incoherent motion, kurtosis). We provide a general, easy to implement, solution scheme (similar to the Cramér–Rao lower bound approach) that can be used to optimize the acquisition protocol with respect to the $b$-values. We present mathematical proof and phantom as well as in-vivo measurements that corroborate the viability of our method.}
}
@inproceedings{ISMRM2018_5344,
annote={ISMRM2018_5344},
pages={5344},
file={ISMRM2018_5344.pdf:ISMRM2018_5344.pdf:PDF},
title={Investigation of the Effect of Body Posture on Dynamic {ADC} Change during Cardiac Cycle in Human Brain},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5344.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Naoki Ohno and Tosiaki Miyati and Masatomo Uehara and Yuki Hiramatsu and Riho Okamoto and Mitsuhito Mase and Satoshi Kobayashi and Toshifumi Gabata},
abstract={Intracranial conditions are strongly affected by body posture. Apparent diffusion coefficient (ADC) of the brain significantly changes during the cardiac cycle and this change (ΔADC) reflects intracranial condition. However, the effect of body posture on ΔADC has yet to be confirmed. Therefore, we evaluated the ΔADC and ADC of the brain in upright and supine postures using a multi-posture MRI. ΔADC and ADC of the white matter in the upright posture were significantly higher than those in the supine posture. Multi-posture MRI facilitates the noninvasive evaluation of the effect of gravity on intracranial conditions.}
}
@inproceedings{ISMRM2018_5345,
annote={ISMRM2018_5345},
pages={5345},
file={ISMRM2018_5345.pdf:ISMRM2018_5345.pdf:PDF},
title={{GPU} Accelerated Maximum Likelihood Estimation of Diffusion and Kurtosis Tensors with the Rician Noise Model},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5345.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Viljami Sairanen and Jia Liu and Dario Gasbarra},
abstract={Diffusion- and kurtosis tensor estimators generally assume independent and a Gaussian distributed noise. While with adequate signal-to-noise ratios (SNR) this assumption can be made without significant bias in the estimated models, this is not true when utilizing high diffusion weighting thus low SNR. In such case, the Rician noise should be considered with maximum likelihood (ML) estimators for example. Moreover, the mathematical properties of ML estimators could unveil novel details of the underlying diffusion process within the brain. In this work, we present super-fast, GPU accelerated ML estimator with Matlab interface to provide a practical tool for such improved estimation.}
}
@inproceedings{ISMRM2018_5346,
annote={ISMRM2018_5346},
pages={5346},
file={ISMRM2018_5346.pdf:ISMRM2018_5346.pdf:PDF},
title={Rebooting diffusion {MRI} uncertainty distributions in the presence of outliers with {ROBOOT}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5346.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Viljami Sairanen and Derek K Jones and Alexander Leemans and Chantal M. W. Tax},
abstract={Characterizing uncertainty distributions in diffusion MRI derived metrics such as fractional anisotropy or kurtosis anisotropy requires non-parametric approaches, since the correct form of the distribution is rarely known a priori. Previously suggested wild bootstrapping methods, however, have not considered the impact of outliers in the data. In this work, we updated the existing wild bootstrap methodology to consider outliers detected by a robust model estimator, adopting a strategy similar to the rejection of the outliers prior to the model estimate. Additionally, we used simulations based on real human data to demonstrate the benefits of our pipeline for recovering uncertainty distributions.}
}
@inproceedings{ISMRM2018_5347,
annote={ISMRM2018_5347},
pages={5347},
file={ISMRM2018_5347.pdf:ISMRM2018_5347.pdf:PDF},
title={Automated Pattern Recognition Analysis of Intravoxel Incoherent Motion ({IVIM})-diffusion to Segment Hypo-perfused Stroke Region},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5347.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={MinJung Jang and SoHyun Han and HyungJoon Cho},
abstract={The variation in fitted perfusion factors (f) from different fitting models and the necessary parameter thresholdings are one of the challenges in the robust interpretation of intravoxel incoherent motion (IVIM) diffusion data [1-3]. The purpose of this study is to investigate the feasibility of applying constrained nonnegative matrix factorization (cNMF) to IVIM-diffusion data for the automatic segmentation of hypo-perfused stroke region of rat brain without any model-fittings nor thresholdings.}
}
@inproceedings{ISMRM2018_5348,
annote={ISMRM2018_5348},
pages={5348},
file={ISMRM2018_5348.pdf:ISMRM2018_5348.pdf:PDF},
title={Digital {DWI} phantoms for non-Gaussian diffusion with Rician noise},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5348.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Dariya I Malyarenko and Yuxi Pang and Thomas L Chenevert},
abstract={Multi-parametric diffusion models describe non-Gaussian diffusivity of tissue observed by quantitative diffusion weighted imaging (qDWI). The ground-truth values for assumed model parameters are useful for both testing the analysis algorithms and optimizing qDWI acquisition. These values can be provided by virtual phantoms, termed digital reference objects (DROs), based on forward modeling. Here we describe a tool to generate DWI DICOM DROs with varying diffusivity model parameters and b-values including physical noise. Application examples are shown for Kurtosis, Stretched Exponential and Perfusion-fraction Intra-Voxel Incoherent-Motion DWI DROs to quantify noise-induced bias and variation in derived qDWI parametric maps.}
}
@inproceedings{ISMRM2018_5349,
annote={ISMRM2018_5349},
pages={5349},
file={ISMRM2018_5349.pdf:ISMRM2018_5349.pdf:PDF},
title={Impact of scan and fitting parameters on the accuracy of parameter maps in {IVIM}-diffusion-{MRI} of the knee joint},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5349.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Anna-Katinka Bracher and Meinrad Beer and Volker Rasche and Henning Neubauer},
abstract={Intravoxel Incoherent Motion (IVIM) imaging has proven its potential for combined diffusion and perfusion imaging of synovitis in the knee joint. In this abstract the impact of the maximum B-value B
max and the threshold B-value B
cutoff - which separates the B-values for the fitting function in perfusion and non-perfusion part - were investigated. The parameter maps show high dependency on B
cutoff and only slight variations on B
max.}
}
@inproceedings{ISMRM2018_5350,
annote={ISMRM2018_5350},
pages={5350},
file={ISMRM2018_5350.pdf:ISMRM2018_5350.pdf:PDF},
title={Diffusion and Perfusion Analysis using Intravoxel Incoherent Motion ({IVIM}): A Twenty Patient Study with Osteosarcoma},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5350.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Esha Baidya Kayal and Devasenathipathy Kandasamy and Kedar Khare and Raju Sharma and Sameer Bakhshi and Amit Mehndiratta},
abstract={Quantitative analysis of Intravoxel incoherent motion (IVIM) effect of diffusion weighted imaging can assess both diffusion and perfusion component of tissue separately. To the best of our knowledge, IVIM analysis in primary bone tumors has not been reported yet and no reference for IVIM parameter values in bone tumors is available for simulation study. We estimated quantitative IVIM parameters using state-of-the-art IVIM analysis method – Bi-exponential model with adaptive Total Variation penalty function (BE+TV) in a cohort of twenty patients with Osteosarcoma that is useful for IVIM analysis in bone tumors for prognosis and can serve as standard reference for future studies.}
}
@inproceedings{ISMRM2018_5351,
annote={ISMRM2018_5351},
pages={5351},
file={ISMRM2018_5351.pdf:ISMRM2018_5351.pdf:PDF},
title={Features extracted from diffusion-driven tensor based morphometry can serve as a specific imaging marker for Moebius Syndrome},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5351.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Neda Sadeghi and Irini Manoli and Timothy Wood and Francis S. Collins and Ethylin Wang Jabs and Elizabeth C. Engle and Moebius Syndrome Research Consortium and Carlo Pierpaoli},
abstract={Quantitative diffusion derived metrics such as fractional anisotropy (FA) and Trace of diffusion tensor (TR) have been used in many studies to assess differences between a subject group and a control group. In this study, in addition to FA and TR, we also look at morphological differences measured by diffusion-driven tensor based morphometry (DTBM). We use DTBM to extract features for use in classification of Moebius syndrome subjects, a rare birth defect characterized by paralysis or weakness of facial muscles and impairment of ocular abduction.}
}
@inproceedings{ISMRM2018_5352,
annote={ISMRM2018_5352},
pages={5352},
file={ISMRM2018_5352.pdf:ISMRM2018_5352.pdf:PDF},
title={Brain q-space imaging: Mean displacement measurement by {SMS}, grid sampling and multi-shell {QSI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5352.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Koji Sakai and Hiroyasu Ikeno and Hiroshi Imai and Kentaro Akazawa and Masashi Yasuike and Hitomi Nagano and Kei Yamada},
abstract={The comparisons of mean displacement (MD) from multi-shell QSI (msQSI) and grid sampling QSI (gsQSI) were executed by anisotropic diffusion phantom and human brain. In addition, the effect of the number of slices excited and acquired simultaneously (SMS factor) we also investigated. The MDs of msQSI and gsQSI were different. The shorter diffusion time on gsQSI might effect these differences. SMS factors on msQSI showed difference among the acceleration. On contrary, SMS factors on gsQSI did not show any difference among the acceleration.}
}
@inproceedings{ISMRM2018_5353,
annote={ISMRM2018_5353},
pages={5353},
file={ISMRM2018_5353.pdf:ISMRM2018_5353.pdf:PDF},
title={Physiological noise at low diffusion weighting reduces repeatability of apparent diffusion coefficient independent of underlying diffusion curve characteristics},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5353.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Neil Peter Jerome and Igor Vidic and Liv Egnell and Torill E. Sjøbakk and Agnes Østlie and Hans E. Fjøsne and Tone F. Bathen and Pål Erik Goa},
abstract={The apparent diffusion coefficient is a powerful imaging biomarker, sensitive to microstructure properties and possessing excellent repeatability. Exclusion of perfusion influence (b<150 s.mm
-2) reflects true diffusivity, although fewer data points reduces precision and thus repeatability. We investigate repeatability of experimental breast diffusion data and show an unexpected increased repeatability with low b-value data inclusion, in contrast to simulated data. This indicates that experimentally-acquired low b-values contains additional noise, perhaps modulated by the non-Gaussianity of the underlying diffusion processes, that decreases diffusion modelling repeatability independent of the true diffusion curve and should be considered as part of the analysis strategy.}
}
@inproceedings{ISMRM2018_5354,
annote={ISMRM2018_5354},
pages={5354},
file={ISMRM2018_5354.pdf:ISMRM2018_5354.pdf:PDF},
title={{EDDY} {QC}: Automated quality control for diffusion {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5354.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Matteo Bastiani and Jesper Andersson and Michiel Cottaar and Fidel Alfaro-Almagro and Sean P Fitzgibbon and Sana Suri and Stamatios N Sotiropoulos and Saad Jbabdi},
abstract={Given the very large number of individual datasets acquired in recent population imaging studies, it is becoming essential to automate data quality control (QC). Here we present an automated QC framework to assess diffusion MRI data both at the single subject and group levels. The QC metrics are derived through different stages of FSL’s pre-processing tools (TOPUP and EDDY). We show that using this framework, it is possible to distinguish between good and bad quality datasets and, importantly, identify subsets of the data that may need careful visual inspection. We hope this QC tool will help harmonisation efforts across sites/studies.}
}
@inproceedings{ISMRM2018_5355,
annote={ISMRM2018_5355},
pages={5355},
file={ISMRM2018_5355.pdf:ISMRM2018_5355.pdf:PDF},
title={An open-source framework for analysis of multidimensional diffusion {MRI} data implemented in {MATLAB}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5355.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Markus Nilsson and Filip Szczepankiewicz and Björn Lampinen and André Ahlgren and João P. de Almeida Martins and Samo Lasic and Carl-Fredrik Westin and Daniel Topgaard},
abstract={Reproducible research requires robust methods for data management and analysis. We have developed a comprehensive analysis framework for diffusion MRI data based on a robust but flexible management of data and metadata, which enables rapid prototyping and sharing of code. The framework is tailored to deal with multidimensional diffusion MRI data featuring novel types of diffusion encoding strategies, such as b-tensor encoding. It also features routines for higher order tensor mathematics as well as adapted volume registration for motion correction, an analysis GUI and other tools.}
}
@inproceedings{ISMRM2018_5356,
annote={ISMRM2018_5356},
pages={5356},
file={ISMRM2018_5356.pdf:ISMRM2018_5356.pdf:PDF},
title={Different Models of Ultra-high b-Value {DWI} for Better Detection of Restricted Diffusion},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5356.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Qiqi Tong and Hongjian He and Tianyi Qian and Yi Sun and Ting Gong and Jianhui Zhong},
abstract={Diffusion-weighted imaging with high b-value can potentially capture the restricted diffusion in tissues. With high-b-value diffusion weighting, the signal in tissue decays non-exponentially, thus the expansion of DWI signal usually be interpreted at second order or higher. However, in the ultra-high b-value (b>4k s/mm
2), the cumulant expansion of higher order would fail to fit the signal. In this study, DTI, DKI, biexponential and Kärger models were used for approximating DWI signals with ultra-high b-values.}
}
@inproceedings{ISMRM2018_5357,
annote={ISMRM2018_5357},
pages={5357},
file={ISMRM2018_5357.pdf:ISMRM2018_5357.pdf:PDF},
title={Intravoxel Incoherent Motion Imaging of Thermoregulation in Skeletal Muscle},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5357.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Kemal Sümser and Juan Antonio Hernandez-Tamames and Gerard Cornelis van Rhoon and Margarethus Marius Paulides},
abstract={Accurate temperature dependent perfusion maps are needed for accurate thermal modelling. In this study, perfusion maps were created for human leg muscle at rest and under cold stress using Intravoxel Incoherent Motion (IVIM) Diffusion Weighted Imaging. IVIM parameters decreasesignificantly under cold stress. Consistency of inter-subject measurements proved IVIM method is suitable for imaging temperature dependent perfusion maps.}
}
@inproceedings{ISMRM2018_5358,
annote={ISMRM2018_5358},
pages={5358},
file={ISMRM2018_5358.pdf:ISMRM2018_5358.pdf:PDF},
title={Comparative study of {DKI} model and traditional {DWI} model in diagnosis of breast cancer},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5358.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ting Li and Siying Wang and Yun Xiong and Kangan Li},
abstract={The aim of this study is to compare the value of diffusion kurtosis imaging model with traditional single-index diffuse weighted imaging model parameters in the differential diagnosis of benign and malignant breast lesions. The rusults showed that the parameters of DKI model and traditional DWI model can be used to differentiate benign and malignant breast lesions. The diagnostic value of MK value in DKI model is the largest. There is a certain correlation between DKI model parameters and prognostic factors.}
}
@inproceedings{ISMRM2018_5359,
annote={ISMRM2018_5359},
pages={5359},
file={ISMRM2018_5359.pdf:ISMRM2018_5359.pdf:PDF},
title={Differential Diagnosis of Intrahepatic Cholangiocarcinoma and Hepatocellular Carcinoma by Using Diffusion-tensor Imaging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5359.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Lihua Chen and Ailian Liu and Qingwei Song and Lizhi Xie},
abstract={The advent of functional MR imaging has facilitated an increased role for imaging in risk stratification and treatment planning. In this study, DTI and DWI MR measurements were performed to investigate the correlation of the FA and ADC values in ROIs of the intrahepatic cholangiocarcinoma (ICC) and hepatocellular carcinoma (HCC) and in further the sensitivity, specificity and accuracy of the parameters for the diagnosis. DTI working at present scanning hardware are more capable to detect the pathophysiological changes unattainable compare to conventional MRI techniques.}
}
@inproceedings{ISMRM2018_5360,
annote={ISMRM2018_5360},
pages={5360},
file={ISMRM2018_5360.pdf:ISMRM2018_5360.pdf:PDF},
title={The diagnostic capability of diffusion Kurtosis Imaging in distinguishing cervical lymphoma from nasopharyngeal carcinoma metastases},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5360.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Cuifang Chen and Jing Zhong and Yunbin Chen and Weibo Chen},
abstract={In our prospective study, We compared DKI and DWI related parameters in order to investigate the diagnostic capability of DKI in distinguishing cervical lymphoma from nasopharyngeal carcinoma(NPC) metastases. The ROC curve showed that K value of DKI had no significantly diagnostic capability, whlie D value of DKI had a better diagnostic performance than the ADC value of DWI in distinguishing the cervical lymphoma from the NPC metastases. Therefore, DKI may be a better noninvasive imaging biomarker for distinguishing the lymphoma and NPC metastases involving the head and neck.}
}
@inproceedings{ISMRM2018_5361,
annote={ISMRM2018_5361},
pages={5361},
file={ISMRM2018_5361.pdf:ISMRM2018_5361.pdf:PDF},
title={An Analytical Segmented ({AS}) Approach for Extracting IntraVoxel Incoherent Motion ({IVIM}) Model Parameters},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5361.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Erick Buko and Jiming Zhang and Afis Ajala and Pei-Herng Hor and Raja Muthupillai},
abstract={Although IVIM model can provide valuable insight into tissue perfusion and microstructure without the need for contrast, the estimation of model parameters with sufficient accuracy continues to be a challenge. In this work, we propose a analytical segmented (AS) approach for estimating IVIM model parameters describing tissue perfusion (Df and f) and tissue diffusion (Ds) and compare the performance of this work against conventional approaches using numerical simulations. Results from our work suggest that AS approach can minimize errors in the estimation of metrics characterizing perfusion, i.e., f and Df compared to conventional approaches (full fitting , segmented and oversegmented methods) even for tissues with low Df/Ds ratios.}
}
@inproceedings{ISMRM2018_5362,
annote={ISMRM2018_5362},
pages={5362},
file={ISMRM2018_5362.pdf:ISMRM2018_5362.pdf:PDF},
title={Inadequate modeling of diffusion anisotropy can lead to artefactual {IVIM} effects: evidence from numerical simulations},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5362.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Gabrielle Fournet and Luisa Ciobanu and Denis Le Bihan},
abstract={The interest in studying perfusion anisotropy using IVIM imaging is growing. However, due to the small amount of perfusion in some tissues, IVIM imaging is highly sensitive to imperfections in the analysis. In this work, we investigate the impact of improperly modeling diffusion anisotropy on the IVIM effect. Performing numerical simulations of a perfusion-free tissue using different sets of diffusion directions and tissue orientations, we show that fitting anisotropic diffusion to the Kurtosis model creates a direction- and orientation-dependent IVIM effect, which can be minimized by taking the geometric mean of the signals with at least 6 properly chosen directions.}
}
@inproceedings{ISMRM2018_5363,
annote={ISMRM2018_5363},
pages={5363},
file={ISMRM2018_5363.pdf:ISMRM2018_5363.pdf:PDF},
title={Non-Gaussian {DWI} of breast lesions at high b-values},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5363.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Igor Vidic and Liv Egnell and Neil P. Jerome and Torill E. Sjøbakk and Agnes Østlie and Hans E. Fjøsne and Roshan Karunamuni and Nathan S. White and Rebecca Rakow-Penner and Anders M. Dale and Tone F. Bathen and Pål Erik Goa},
abstract={In this work, we fit multiple non-Gaussian models to high b-value DW-MRI (b= 200-3000 s/mm
2) in benign and malignant breast lesions. Models included bi-exponential, stretched exponential, diffusion kurtosis, Padé exponent and ADC (for comparison). We evaluated the quality of fit for each model and investigated the lesion differentiation accuracy for all extracted model parameters. The bi-exponential model provided statistically significant better quality of fit than all the other models and without systematic bias. This suggests the existence of two effective diffusion compartments in breast lesions. Several of the extracted model parameters performed equally well in terms of lesion differentiation (AUC>0.97).}
}
@inproceedings{ISMRM2018_5364,
annote={ISMRM2018_5364},
pages={5364},
file={ISMRM2018_5364.pdf:ISMRM2018_5364.pdf:PDF},
title={Measurement biases in diffusion and diffusion kurtosis {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5364.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Nima Gilani and Hamidreza Saligheh Rad and Glyn Johnson},
abstract={Water diffusion in tissue is non-Gaussian and the expressions used to calculate diffusion parameters are approximations which introduce systematic errors dependent on the maximum b-value employed. The purpose of this study was to characterize biases in estimates of both apparent diffusion coefficient and kurtosis and to determine their dependence on maximum b-value. Hence, equations were derived to predict biases in measured diffusion parameters and to explain much of the discrepancy between measurements obtained with different b-values. The equations may also be used to choose appropriate maximum b-values for diffusion-weighted, tensor and kurtosis imaging.}
}
@inproceedings{ISMRM2018_5365,
annote={ISMRM2018_5365},
pages={5365},
file={ISMRM2018_5365.pdf:ISMRM2018_5365.pdf:PDF},
title={Can Apparent Diffusion Coefficient from Ultra-high b-Values be Used to Assess Renal Function with Murine Model of Unilateral Ureteral Obstruction?},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5365.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Anqin Li and Zhen Li and Jiali Li and Yao Hu and Daoyu Hu},
abstract={To evaluate the utility of apparent diffusion coefficient (ADC) data obtained from ultra-high b-values in renal function using with rat model of unilateral ureteral obstruction (UUO). We compared the differences of ADCuh among time points and between the sides and determined the correlation of ADCuh with positron emission tomography (PET) renal function and expression of aquaporin 2 (AQP-2). ADCuh of the UUO sides on day 0 was significantly lower than that of on day 1, 3, 5 and 7. ADCuh was negatively correlated with SUV both on the UUO side and contralateral side. Therefore, ADCuh may have a certain value to help evaluate renal function.}
}
@inproceedings{ISMRM2018_5366,
annote={ISMRM2018_5366},
pages={5366},
file={ISMRM2018_5366.pdf:ISMRM2018_5366.pdf:PDF},
title={Bayesian estimation applied to stretched exponential modelling of diffusion-weighted imaging data},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5366.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Peter Thomas While},
abstract={The stretched exponential model provides a means of assessing non-monoexponential signal attenuation in diffusion-weighted imaging data. However, standard least squares approaches to parameter estimation remain susceptible to noise. In this work, we apply two distinct Bayesian approaches to stretched exponential modelling and assess their performance at low-medium b-values using simulations. The use of a spatial homogeneity prior is found to yield parameter maps with higher precision and accuracy than those obtained with the use of a Gaussian shrinkage prior or nonlinear least squares.
}
}
@inproceedings{ISMRM2018_5367,
annote={ISMRM2018_5367},
pages={5367},
file={ISMRM2018_5367.pdf:ISMRM2018_5367.pdf:PDF},
title={Impact of time-of-day on diffusivity measures of brain tissue derived from diffusion tensor imaging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5367.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Cibu Thomas and Neda Sadeghi and Aaron Trefler and Joelle Sarlls and Chris Baker and Carlo Pierpaoli},
abstract={Although diurnal fluctuations in DTI-based measures of brain tissue properties have been reported, the underlying mechanism has not been investigated. Here, we processed multi-shell diffusion data using the conventional monoexponential tensor model as well as with a dual-compartment tensor model and assessed whether, time-of-day (TOD) fluctuations in DTI measures are due to changes in the magnitude of a CSF-like water compartment, or due to changes in the diffusion properties of parenchymal water. Our results suggest that TOD effects are due to fluctuations in the magnitude of a CSF-like water compartment rather than changes in the diffusion properties of parenchymal water.}
}
@inproceedings{ISMRM2018_5368,
annote={ISMRM2018_5368},
pages={5368},
file={ISMRM2018_5368.pdf:ISMRM2018_5368.pdf:PDF},
title={Longitudinal Changes in Gray Matter Regions after Cranial Radiation and Comparative Analysis with Whole Body Radiation: A {DTI} Study},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5368.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Poonam Rana and Apurva Watve and Mamta Gupta and Richa Trivedi and Subash Khushu},
abstract={Radiation induced white matter changes are well known and vastly studied. However, radiation induced gray matter alterations are still a research question. In the present study, DTI based gray matter changes in C57BL/6 mice were studied following cranial and whole body irradiation at 5 Gy during sub acute and early delayed time point. Longitudinal changes in FA and MD were observed till 8 months post radiation. Comparative analysis depicted differential response after cranial and whole body radiation exposure with prominent alterations in cranially irradiated animals. with most changes at 8 months post irradiation}
}
@inproceedings{ISMRM2018_5369,
annote={ISMRM2018_5369},
pages={5369},
file={ISMRM2018_5369.pdf:ISMRM2018_5369.pdf:PDF},
title={Brain axonal and myelin changes after positive airway pressure treatment in patients with obstructive sleep apnea},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5369.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ashish Kaul Sahib and Bhaswati Roy and Xiaopeng Song and Sadhana Singh and Luke Ehlert and Ravi Aysola and Daniel Kang and Mary Woo and Rajesh Kumar},
abstract={Newly-diagnosed, treatment-naïve obstructive sleep apnea subjects show predominately acute tissue changes in gray and white matter, in addition to autonomic, mood and cognitive deficits, but the extent of brain tissue recovery after PAP treatment and required minimum treatment time is unclear. We examined brain axonal and myelin changes at baseline and tissue recovery after 3 and 9 months’ positive airway pressure treatment in OSA compared to control subjects. Our findings indicate that brain structural changes found in newly-diagnosed OSA subjects can be reversible with long-term PAP treatment.}
}
@inproceedings{ISMRM2018_5370,
annote={ISMRM2018_5370},
pages={5370},
file={ISMRM2018_5370.pdf:ISMRM2018_5370.pdf:PDF},
title={Investigating the spatial pattern of structural changes of the Optic Radiation in early blind individuals.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5370.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Lisa Novello and Chiara Maffei and Hicret Atilgan and Stefania Mattioni and Ceren Battal and Mohamed Rezk and Olivier Collignon and Jorge Jovicich},
abstract={The study of sensory deprived individuals shows the capability of the brain to massively reorganize. Previous studies show that the optic tract of early blind individuals undergoes structural changes, but little is known about their spatial distribution. We investigated the spatial profile of the structural changes occurring along tractography reconstruction from diffusion MRI data of the optic radiations in early blind individuals compared to age- and gender-matched healthy sighted controls.}
}
@inproceedings{ISMRM2018_5371,
annote={ISMRM2018_5371},
pages={5371},
file={ISMRM2018_5371.pdf:ISMRM2018_5371.pdf:PDF},
title={Abnormal cerebellar wiring in a mouse model of Down syndrome revealed by {HARDI}-based tractography},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5371.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Dan Wu and Feng Gao and Roger Reeves},
abstract={We investigated the cerebellar microstructure and wiring diagram in a mouse model of Down syndrome (DS), using HARDI-based tractography analysis. Our results showed an absence of cerebellar climbing fibers (CF) and/or mossy fibers (MF) in the intra-granule layer of the DS mice at neonatal stage, when those fiber tracts started to form in the control neonatal brains. In the adult mice, two groups of crossing fibers—the CF/MF fibers versus the parallel fibers (PF) were identified, but the number of crossing fibers and apparent fiber density was significantly reduced in the granule layer of the DS mice, especially for the CF/MF group.}
}
@inproceedings{ISMRM2018_5372,
annote={ISMRM2018_5372},
pages={5372},
file={ISMRM2018_5372.pdf:ISMRM2018_5372.pdf:PDF},
title={Using Double Diffusion Encoding ({DDE}) {MRI} to study tissue microstructure in traumatic brain injury ({TBI})},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5372.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Michal E Komlosh and Dan Benjamini and Elizabeth B Hutchinson and Sarah King and Margalit Haber and Alexandru V Avram and Lynne A Holtzclaw and Abhishek Desai and Carlo Pierpaoli and Peter J Basser},
abstract={A double diffusion encoding (DDE) MRI method was used to estimate apparent mean axon diameter (AMD) in a mild traumatic brain injury (mTBI) mouse model exhibitig diffuse axonal injury (DAI). MRI data show clear tissue alterations caused by the injury, while immunohistochemistry data confirm the MRI findings. DDE could potentially be used as a non-invasive means to detect mTBI.}
}
@inproceedings{ISMRM2018_5373,
annote={ISMRM2018_5373},
pages={5373},
file={ISMRM2018_5373.pdf:ISMRM2018_5373.pdf:PDF},
title={Comparison of diffusion {MR} models in lymph nodes at ultra high field},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5373.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Andrada Ianus and Ines Santiago and Daniel C. Alexander and Celso Matos and Noam Shemesh},
abstract={Diffusion MRI could play an important role for detection and characterisation of lymph nodes, however, the standard ADC metric lacks specificity and cannot accurately capture the signal decay. Multi-compartment models aim to represent the signal contribution of different water pools in order to better explain the acquired data. In this study, a rich dMRI dataset is acquired for ex-vivo lymph nodes and various diffusion models are fitted. The results show that including compartments which feature restricted diffusion improves the signal fit. Although such models have only a slight impact on lymph node differentiation, they could potentially provide more specific biomarkers.}
}
@inproceedings{ISMRM2018_5374,
annote={ISMRM2018_5374},
pages={5374},
file={ISMRM2018_5374.pdf:ISMRM2018_5374.pdf:PDF},
title={Heterochronous regional white matter development in pre-adolescent children: diffusion kurtosis imaging study},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5374.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Farida Grinberg and Ezequiel Farrher and Kerstin Konrad and Irene Neuner and N. Jon Shah},
abstract={Diffusion tensor imaging and, more recently, diffusion kurtosis imaging enables the examination of white matter connectivity and of in vivo microstructural changes across the lifespan. However, only very few diffusion kurtosis imaging studies have addressed white matter maturation. Here we explore which specific brain regions continue to develop throughout late childhood into the adulthood as revealed by kurtosis tensor metrics. We show the potential of these metrics as maturation-sensitive biomakerscapable of elucidating maturation heterochronicity of various white matter tract groups, such as association, projection and commissural fibres.}
}
@inproceedings{ISMRM2018_5375,
annote={ISMRM2018_5375},
pages={5375},
file={ISMRM2018_5375.pdf:ISMRM2018_5375.pdf:PDF},
title={Oscillating Gradient Spin Echo Diffusion Tensor {MRI} of Acute Human Stroke},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5375.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Christian Beaulieu and Leka Sivakumar and Ken Butcher and Sarah Treit and Derek Emery and Robert Stobbe},
abstract={Different spatial scales of micro-structural alteration with disease can be interrogated by varying the time water has to interact with its surroundings (e.g. membranes, etc). Oscillating gradient spin echo (OGSE) diffusion MRI enables much shorter diffusion times (e.g. 6 ms) than typical pulsed gradient spin-echo (PGSE) (e.g. 40 ms). The large diffusion reduction typically observed with PGSE in ischemic lesions in human stroke was markedly less with OGSE and the OGSE-PGSE difference was greatest for radial diffusivity in ischemic white matter. This result is consistent with the swelling and beading of the axons underlying diffusion contrast in cerebral ischemia.}
}
@inproceedings{ISMRM2018_5376,
annote={ISMRM2018_5376},
pages={5376},
file={ISMRM2018_5376.pdf:ISMRM2018_5376.pdf:PDF},
title={Non-invasive quantification of inflammation, axonal and myelin injury in {MS}: a 7T {DBSI} study},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5376.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Simona Schiavi and Peng Sun and Sirio Cocozza and Maria Petracca and Mohamed Mounir El Mendili and Kornelius Podranski and Matilde Inglese and Sheng-Kwei Song},
abstract={Diffusion basis spectrum imaging (DBSI) has successfully distinguished co-existing pathological processes in CNS diseases, such as multiple sclerosis (MS). The aim of our study was to determine the feasibility of DBSI in MS patients at 7T and to investigate the underlying pathological substrates of different lesion types and normal appearing white matter (NAWM). For the first time, we proved the feasibility of DBSI at 7T, validating the specificity of the different metrics to diverse pathological substrates. Additionally, we employed DBSI metrics to characterize focal and diffuse tissue damage in different MS phenotypes, confirming their utility as biomarkers of tissue-specific microstructural damage.}
}
@inproceedings{ISMRM2018_5377,
annote={ISMRM2018_5377},
pages={5377},
file={ISMRM2018_5377.pdf:ISMRM2018_5377.pdf:PDF},
title={Diffusion Basis Spectrum Imaging and Diffusion Tensor Imaging in Mouse Model of Traumatic Brain Injury},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5377.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Harri Merisaari and Tsen-Hsuan Lin and Gentian Toshkezi and Michele Kyle and Zhao Li-Ru and Sheng-Kwei Song},
abstract={Traumatic brain injury (TBI) is a major cause of acquired brain injury in both children and adults. Traumatic axonal injury (TAI) is a major contributor to cognitive dysfunction followed by TBI. Diffusion Tensor Imaging (DTI) has shown to characterize TAI in non-invasive manner. However, DTI as a gross measure has limitations in its parameters in detection capability of underlying pathologies. Diffusion Basis Spectrum Imaging (DBSI) is an advanced imaging technique that has been applied to investigate nervous system pathology. Accurate characterization of brain pathologies in vivo, such as axonal injury, is extremely important in the study of changes that occur over time after TBI. To investigate these two methods in TBI data, we performed a comparison in mouse model between control and injured groups.}
}
@inproceedings{ISMRM2018_5378,
annote={ISMRM2018_5378},
pages={5378},
file={ISMRM2018_5378.pdf:ISMRM2018_5378.pdf:PDF},
title={q-Space Novelty Detection in Short Diffusion {MRI} Scans of Multiple Sclerosis},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5378.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Vladimir Golkov and Aleksei Vasilev and Francesco Pasa and Ilona Lipp and Wassim Boubaker and Eleonora Sgarlata and Franz Pfeiffer and Valentina Tomassini and Derek K. Jones and Daniel Cremers},
abstract={Diffusion MRI can capture disease-related microstructural changes, but most methods use handcrafted data transformations that discard parts of the information and require quite long scan times. In contrast, q-space novelty detection (q-ND) circumvents these drawbacks and does not require any knowledge whatsoever about the effect of disease on q-space measurements. Instead, q-ND highlights voxels that look unlike anything seen in a database of healthy scans. Here we show that novelty scores from q-ND largely coincide with multiple sclerosis lesions and that q-ND also works at reduced scan times.}
}
@inproceedings{ISMRM2018_5379,
annote={ISMRM2018_5379},
pages={5379},
file={ISMRM2018_5379.pdf:ISMRM2018_5379.pdf:PDF},
title={Diffusion-weighted imaging reveals microstructural alterations in a transgenic rat model of Alzheimer’s disease - validation against immunohistochemistry},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5379.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Hamied A Haroon and Ben R Dickie and Matthias Vandesquille and Charlotte Auty and Herve Boutin and Geoffrey JM Parker and Laura M Parkes},
abstract={Diffusion-weighted imaging (DWI) holds the promise of detecting very subtle neuronal changes in Alzheimer’s disease (AD). We compare the sensitivity of different DWI metrics to microstructural change in a transgenic rat model of AD. We find genotype-related differences in regions known to be affected in AD, with NODDI metrics showing greater sensitivity than FA and MD. However, no genotype-related difference in neuronal density is detected using immunohistochemistry staining for NeuN suggesting that the DWI changes reflect alterations in the neuronal structure (dendritic density or myelination) rather than density. DWI metrics are however correlated with neuronal density on a regional basis.}
}
@inproceedings{ISMRM2018_5380,
annote={ISMRM2018_5380},
pages={5380},
file={ISMRM2018_5380.pdf:ISMRM2018_5380.pdf:PDF},
title={Towards a ‘resolution limit’ for {DW}-{MRI} tumour microstructural models: what microstructural changes can be distinguished?},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5380.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Damien J. McHugh and Geoffrey J. M. Parker},
abstract={The ability to detect specific changes in tumour tissue using diffusion-weighted (DW) MRI microstructural models depends on the accuracy and precision of parameter estimates, as well as the magnitude of specific biological changes. This work investigates the SNR requirements that data must meet in order to yield sufficiently precise estimates for detecting apoptotic cell shrinkage. Given the relative changes in cell size, R and intracellular volume fraction, f
i, as a result of apoptosis, simulations indicate that detecting changes in R require ~4-fold higher SNR than detecting changes in f
i. Comparing the magnitude of biological changes with measurement accuracy and precision should form part of the validation process for potential biomarkers.}
}
@inproceedings{ISMRM2018_5381,
annote={ISMRM2018_5381},
pages={5381},
file={ISMRM2018_5381.pdf:ISMRM2018_5381.pdf:PDF},
title={Demyelination or not: increased radial diffusivity in Parkinson’s disease},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5381.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ruimeng Yang and Pen Sun and Xiangling Zeng and Ajit George and Ajit George and xinhua Wei and xinqing jiang and Sheng-Kwei Song},
abstract={White matter (WM) integrity alteration has been noted in Parkinson’s disease (PD). Whether the increased radial diffusivity (RD) revealed in previous study using diffusion tensor imaging (DTI) in PD patients is suggestive of demyelinating etiology remains to be established. To further investigate white matter (WM) microstructure changes in PD, diffusion tensor imaging (DTI) and diffusion basis spectrum imaging (DBSI) were analyzed using Tract Based Spatial Statistics (TBSS). Both whole brain voxel-based group analysis and reginal analysis on the corpus callosum were performed. DBSI results suggest that axonal injury is present in PD while no myelin injury was seen.}
}
@inproceedings{ISMRM2018_5382,
annote={ISMRM2018_5382},
pages={5382},
file={ISMRM2018_5382.pdf:ISMRM2018_5382.pdf:PDF},
title={Diffusion kurtosis imaging in chronic disorders of consciousness: state estimation and treatment prognosis},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5382.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Elena Kremneva and Lyudmila Legostaeva and Sofya Morozova and Elizaveta Mochalova and Dmitry Sinitsyn and Natalia Suponeva and Marina Krotenkova and Aleksandr Suslin and Mikhail Piradov and Ivan Maximov},
abstract={Chronic disorders of consciousness (DOC) are severe neurological disorders due to lesions massively affecting the brain. The treatment and prognosis in the case of DOC is an actual problem demanding novel imaging approaches, in particular, allowing one to determine the extend of brain structural changes. Diffusion-weighted MRI is a powerful candidate for in vivo probing and visualization of brain damage severity in DOC patients. In order to investigate white matter microstructural changes associated with the chronic DOC we performed tract-based spatial statistics analysis and complementary brainstem diffusion metric comparisons between patients and healthy control groups. Our findings revealed large white matter changes in the DOC patients, in particular, using novel and sensitive biomarkers based on the kurtosis scalar metrics. We hope that our discoveries help us to improve a forthcoming treatment of DOC patients.}
}
@inproceedings{ISMRM2018_5383,
annote={ISMRM2018_5383},
pages={5383},
file={ISMRM2018_5383.pdf:ISMRM2018_5383.pdf:PDF},
title={Spinal cord axonal diameter variations in the relapsing remitting {EAE} mouse model of multiple sclerosis},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5383.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ahmad Joman Alghamdi and Ian M. Brereton and Nemat Khan and Maree Smith and Nyoman D. Kurniawan},
abstract={This study aimed to determine the extent of axon diameter distribution changes in the lumbar spinal cord in C57BL/6 mice associated with experimental autoimmune encephalomyelitis (EAE). AxCaliber protocol was performed ex-vivo at 16.4T to analyze changes in mice with a range of EAE severity and the effect of treatment with alpha-lipoic acid (R-ALA), a nutraceutical compound that is recently known for suppressing microglial activation and CNS inflammation in EAE rodent models. AxCaliber showed axon diameter increases in mild relapsing remitting EAE group after R-ALA treatment. This might indicate a process of remyelination or other microstructural changes.}
}
@inproceedings{ISMRM2018_5384,
annote={ISMRM2018_5384},
pages={5384},
file={ISMRM2018_5384.pdf:ISMRM2018_5384.pdf:PDF},
title={Brain activations during a motor cortex paradigm: a diffusion {MRI} signal perspective.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5384.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Alberto De Luca and Lara Schlaffke and Jeroen C. W. Siero and Martijn Froeling and Alexander Leemans},
abstract={Brain activations during task are commonly investigated by gradient-echo functional MRI (GE-fMRI), which is sensitive to blood volume changes and blood deoxygenation. Recent studies have shown that diffusion MRI, which is regarded as static in the time-scale of minutes, might be sensitive to changes in activated areas. We investigated changes in signals acquired during a motor cortex paradigm using GE-fMRI and diffusion fMRI (dfMRI). We observed causality between the task and the dfMRI acquired at different diffusion weightings. These preliminary results suggest that the observed changes in the dfMRI signal might not be a pure result of blood volume alterations.}
}
@inproceedings{ISMRM2018_5385,
annote={ISMRM2018_5385},
pages={5385},
file={ISMRM2018_5385.pdf:ISMRM2018_5385.pdf:PDF},
title={White matter micro-structural alterations in Hypothyroid: A Diffusion Kurtosis Imaging study},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5385.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Mukesh Kumar and Poonam Rana and Deepak Sharma and Ratnesh Kanwar and Tarun Sekhri and Maria D’souza and Subash Khushu},
abstract={The aim of our study was to assess changes in brain tissue microstructures in hypothyroid patients using Diffusion Kurtosis Imaging (DKI). The water diffusion in living tissue is hindered by interactions with other molecules and cell membranes. Therefore, water movement in biological tissue is often non-Gaussian and this non-Gaussian behavior may contain useful information related to tissue structure and pathophysiology. Our findings demonstrate widespread reduced kurtosis indices MK, AK; diffusion index FA was decreased and AD was increased in major white matter pathways and such abnormal white matter structure may be linked to cognitive and behavioral impairment in hypothyroid patients.}
}
@inproceedings{ISMRM2018_5386,
annote={ISMRM2018_5386},
pages={5386},
file={ISMRM2018_5386.pdf:ISMRM2018_5386.pdf:PDF},
title={Alterations in white matter connectivity related to language comprehension in patients with Crohn’s disease in remission},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5386.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jiancheng Hou and Keith Dodd and Veena Nair and Poonam Beniwal-Patel and Vivek Prabhakaran and Sumona Saha},
abstract={Reduced white matter integrity in patients with Crohn’s disease (CD) has been previously reported. However few studies have examined the behavioral implications of compromised WM integrity in these patients. Here we report results from an exploratory study investigating group differences in diffusivity measures in patients with Crohn’s disease in remission [compared to age and gender matched healthy control (HC) subjects] and examined their relationship to participants’ performance on a phonemic fluency task. CD patients demonstrate altered brain microstructural changes in regions associated with several cognitive functions including language processing.}
}
@inproceedings{ISMRM2018_5387,
annote={ISMRM2018_5387},
pages={5387},
file={ISMRM2018_5387.pdf:ISMRM2018_5387.pdf:PDF},
title={Alteration in Diffusion Characteristic of Cerebrospinal Fluid after Neurological Disease in Rats},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5387.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jun Tazoe and Yu-Chieh Jill Kao and Chia-Feng Lu and Ping-Huei Tsai and Fei-Ting Hsu and Bao-Yu Hsieh and Cheng-Yu Chen},
abstract={While the quantitative maps conducted by diffusion weighted or diffusion tensor imaging were applied to the brain parenchyma to describe the tissue type and fate, the diffusion coefficient in the cerebrospinal fluid (CSF) was not well explored. In this study, significant lower mean of diffusion constant (D-value) and change in the histogram of D-value were observed in stroke animals compared with intact rats and the mTBI animals, suggesting the brain lesion or damage may alter the diffusion characteristics in CSF.}
}
@inproceedings{ISMRM2018_5388,
annote={ISMRM2018_5388},
pages={5388},
file={ISMRM2018_5388.pdf:ISMRM2018_5388.pdf:PDF},
title={Spatially constrained mathematical models for diffusion weighted imaging of prostate cancer xenografts in mice: evaluation of therapy response},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5388.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Parisa Movahedi and Harri Merisaari and Hanne Laakso and Ileana Montoya Perez and Heidi Liljenbäck and Hannu Aronen and Heikki Minn and Anne Roivainen and Timo Liimatainen and Ivan Jambor},
abstract={Tumor growth in mice preclinical prostate cancer model (human prostate cancer cells, PC-3) was followed for 4 weeks by weekly DWI in control group (n=10) and treatment group (n=9) receiving Docetaxel. DWI data sets were acquired using 12 b-values the range of 0-2000 s/mm2. The DWI signal decays were fitted using monoexponential, biexponential, kurtosis and stretched exponential models/functions. Independent least squares fitting and spatially constrained Maximum Penalized Likelihood Estimation have been applied. The spatially constrained Maximum Penalized Likelihood Estimation revealed the effect of treatment in mice subjects, while conventional LSQ fitting failed to reveal significant difference between control and treatment.}
}
@inproceedings{ISMRM2018_5389,
annote={ISMRM2018_5389},
pages={5389},
file={ISMRM2018_5389.pdf:ISMRM2018_5389.pdf:PDF},
title={Generalised kurtosis imaging approach for glioblastoma evaluation},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5389.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Eduard Pogosbekian and Artem Batalov and Alexander Turkin and Igor Pronin and Ivan Maximov},
abstract={Primary brain gliomas are very a widespread type of intra-axial brain tumours. Brain gliomas have different cellular origins and can be differentiated by WHO 2016 classification. The most aggressive type of glioma is the glioblastoma (GB). Thus, a correct and reliable grading of gliomas, in particular, the GB, is critical for a patient treatment and prognosis. Diffusion kurtosis imaging (DKI) has been applied to glioma validation in order to perform non-invasive evaluation. DKI allowed one to obtain information about microstructure and inhomogeneity differentiation. In the present work we demonstrate advantages of generalised DKI approach for GB detection and evaluation.}
}
@inproceedings{ISMRM2018_5390,
annote={ISMRM2018_5390},
pages={5390},
file={ISMRM2018_5390.pdf:ISMRM2018_5390.pdf:PDF},
title={The Effect of Respiration on Apparent Diffusion Coefficient of the Brain},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5390.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Naoki Ohno and Tosiaki Miyati and Yuki Hiramatsu and Ryoto Shimizu and Mitsuhito Mase and Satoshi Kobayashi and Toshifumi Gabata},
abstract={ADC of the brain significantly changes during the cardiac cycle because of intracranial pressure changes and fluid fluctuations. We hypothesized that ADC of the brain changes during the respiratory cycle because intracranial pressure changes during the respiratory cycle. We determined the maximum and minimum ADC (ADC
max and ADC
min) and maximum change in ADC (ΔADC) in the respiratory cycle and non-synchronized periodical data. ADC
max and ΔADC in the white matter with respiratory-synchronization were significantly greater than those with non-synchronized periodical scan, whereas there was no significant difference in ADC
min between the scans. ADC of the brain changes during the respiratory cycle.
}
}
@inproceedings{ISMRM2018_5391,
annote={ISMRM2018_5391},
pages={5391},
file={ISMRM2018_5391.pdf:ISMRM2018_5391.pdf:PDF},
title={Semi-automatic, Machine Learning Segmentation of Peripheral Nerves in Healthy Volunteers and Patients},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5391.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Fabian Balsiger and Mirjam Arn and Carolin Steindel and Benedikt Wagner and Marwan El-Koussy and Waldo Valenzuela and Mauricio Reyes and Olivier Scheidegger},
abstract={Magnetic resonance neurography (MRN) is increasingly used to diagnose peripheral neuropathy. Here, we propose a semi-automatic multimodal machine learning-based segmentation algorithm to segment peripheral nerves from MRN images. Our algorithm was tested on 9 volunteers and 25 patient cases suffering from sciatic neuropathy. Compared to manual segmentation, Dice coefficients were 0.723 ± 0.202 and 0.443 ± 0.228, respectively, with segmentation times of 5 ± 1 for semi-automatic and 24 ± 8 minutes for manual segmentation. Our preliminary results suggest that machine learning-based segmentation of the sciatic nerve is possible in healthy and diseased nerves in clinically feasible time.}
}
@inproceedings{ISMRM2018_5392,
annote={ISMRM2018_5392},
pages={5392},
file={ISMRM2018_5392.pdf:ISMRM2018_5392.pdf:PDF},
title={Improved brachial plexus visualization using an adiabatic i{MSDE}-prepared {STIR} 3D {TSE}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5392.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Elisabeth Klupp and Barbara Cervantes and Nico Sollmann and Franziska Treibel and Dominik Weidlich and Thomas Baum and Ernst J. Rummeny and Claus Zimmer and Jan S. Kirschke and Dimitrios C. Karampinos},
abstract={The close proximity of blood vessels to the brachial plexus nerves can confound nerve visualization in the preferably used fat suppressed 3D T2 weighted sequences. Vessel suppression can be increased by means of an additional motion-sensitizing preparation (e.g. iMSDE). The aim of this work was the evaluation of STIR 3D-TSE in conjunction with an adiabatic T2 preparation incorporating iMSDE-based motion sensitization for MRN of the brachial plexus in a clinical routine-setting quantitatively and qualitatively. The additional motion-sensitizing iMDSE preparation reveals robust blood suppression, leading to higher CNR, increased conspicuity of the nerves, better image quality and less artifacts.}
}
@inproceedings{ISMRM2018_5393,
annote={ISMRM2018_5393},
pages={5393},
file={ISMRM2018_5393.pdf:ISMRM2018_5393.pdf:PDF},
title={Investigating the value of arterial spin labeling ({ASL}) and intravoxel incoherent motion ({IVIM}) imaging on the diagnosis of nasopharyngeal carcinoma ({NPC}) in T1 stage},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5393.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Meng Lin and Xiaoduo Yu and Lizhi xie},
abstract={T1-stage NPC was difficult to diagnosis using conventional MRI and additional examinations were often needed. This study aimed to investigate ASL and IVIM on diagnosing T1-stage NPC. We measured the BF by ASL and IVIM parameters (D, D*, f, fD*) of T1-stage NPC tumors and nasopharyngeal mucosa of healthy control. The mean BF and D* of T1-stage NPC were higher than those of healthy control. And the BF correlated positively with D* and fD*. Therefore, ASL and IVIM could reflect blood perfusion difference between T1-stage NPC and benign nasopharyngeal mucosa, which is potential to help the early diagnosis of NPC.}
}
@inproceedings{ISMRM2018_5394,
annote={ISMRM2018_5394},
pages={5394},
file={ISMRM2018_5394.pdf:ISMRM2018_5394.pdf:PDF},
title={Normalised Grey Matter and White Matter Volumes in the Neurologically Intact Conus Medullaris},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5394.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Marios C Yiannakas and Martina D Liechti and Patrick Cullinane and Xixi Yang and Ahmed T Toosy and Jalesh N Panicker and Claudia Angela Gandini Wheeler-Kingshott},
abstract={Magnetic Resonance Imaging derived measures of spinal cord (SC) grey matter (GM) and white matter (WM) volume are useful for indirectly assessing neurodegeneration over time (i.e. atrophy). However, for the correct interpretation of such morphometric analyses, one must take into consideration the natural variability that exists between subjects, which is unrelated to a disease process. Various normalisation strategies have been proposed for use in the upper SC, but evidence from similar applications in the lower SC is currently lacking. In this work, we present our first approach to normalisation of GM/WM volumes in the neurologically intact conus medullaris.}
}
@inproceedings{ISMRM2018_5395,
annote={ISMRM2018_5395},
pages={5395},
file={ISMRM2018_5395.pdf:ISMRM2018_5395.pdf:PDF},
title={Development of the fast 3D-{MR} neurography using the optimized combination of the compressed sensing and parallel imaging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5395.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Takuya Aoike and Noriyuki Fujima and Masami Yoneyama and Kinya Ishizaka and Hiroyuki Sugimori and Kohsuke Kudo},
abstract={We assessed the rapid
acquisition design in 3D-MR
neurography (3D-MRN) using compressed sensing (CS) with the combination of the parallel imaging technique. High sparsity in 3D-MRN raw data was considered to be compatible with high CS acceleration factor. This result will be make patients comfortable in daily clinical MRN scanning.}
}
@inproceedings{ISMRM2018_5396,
annote={ISMRM2018_5396},
pages={5396},
file={ISMRM2018_5396.pdf:ISMRM2018_5396.pdf:PDF},
title={Structural and quantitative {MRI} to identify lesion level dependant neurodegeneration after {SCI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5396.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Michela Azzarito and Patrick Grabher and Maryam Seif and Patrick Freund},
abstract={Patients with spinal cord injury (SCI) undergo neurodegeneration affecting the spinal cord and the brain. However, the volumetric and microstructural patterns of degeneration, their relation to lesion level and clinical outcomes are uncertain. In this study, both structural and quantitative MRI approaches are used in order to identify lesion dependent neurodegeneration following SCI. It was found that lesion level drives structural changes in the spinal cord but not brain.}
}
@inproceedings{ISMRM2018_5397,
annote={ISMRM2018_5397},
pages={5397},
file={ISMRM2018_5397.pdf:ISMRM2018_5397.pdf:PDF},
title={Spinal Cord Perfusion is Associated with Diffusion and clinical m{JOA} score in Preoperative Patients with Cervical Spondylotic Myelopathy},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5397.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Chunyao Wang and Xiao Han and Wen Jiang and Guangqi Li and Jinchao Wang and Hua Guo and Huijun Chen},
abstract={Cervical Spondylotic Myelopathy (CSM) is a chronic progressive disorder of spinal cord with a relatively ill-defined onset of pathogenesis. A series of state-of-art quantitative and functional MR imaging techniques have been proposed aiming to find out specific indicators in prediction and diagnosis of CSM at early phase, but lack of sufficient evidences. Spinal cord blood supply change was recognized as one of the crucial pathophysiological process in CSM. Hence, we investigate the relationship between spinal cord blood perfusion assessed by MR DSC with DTI metrics and clinical mJOA score. Finally, we find spinal cord blood flow is significantly correlated with diffusion metrics and mJOA.}
}
@inproceedings{ISMRM2018_5398,
annote={ISMRM2018_5398},
pages={5398},
file={ISMRM2018_5398.pdf:ISMRM2018_5398.pdf:PDF},
title={Diffusion weighted T2-mapping for the determination of tissue characteristics in patients with head and neck squamous cell carcinoma},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5398.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Noriyuki Fujima and Masami Yoneyama and Eunju Kim and Takuya Aoike and Suzuko Aoike and Kohsuke Kudo},
abstract={We investigated the utility of T2 mapping with the pre-pulse of diffusion gradient (DW T2-map) for the determination of tissue characteristics in head and neck squamous cell carcinoma. Significant difference in T2-value of tumor tissue between that with and without diffusion gradient was observed. In addition, DW T2-map was suggested to be one of the diagnostic tool for the prediction of tumor histological grade. DW T2-map can be useful tool for the assessment of tumor tissue characteristics with greater detail.}
}
@inproceedings{ISMRM2018_5399,
annote={ISMRM2018_5399},
pages={5399},
file={ISMRM2018_5399.pdf:ISMRM2018_5399.pdf:PDF},
title={Simultaneous Diffusion Tensor Imaging and T2 relaxometry in Lumbar Nerve Roots using Dual-Echo Single-Shot {DW}-{EPI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5399.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Masami Yoneyama and Takayuki Sakai and Eunju Kim and Tetsuo Ogino and Atsuya Watanabe and Marc Van Cauteren},
abstract={Diffusion tensor imaging (DTI) is promising for evaluation of lumbar nerve root compression in the extraforaminal area. A quantitative assessment using T
2 relaxometry is also promising to evaluate nerve injury. Hence, nerve root quantification using both DTI and T
2 relaxation properties may improve the diagnosis of nerve roots in patients with lower back pain, but it requires a long scan time. In this study, we developed a new sequence to simultaneously obtain both diffusion parameters and T
2 value in one single scan (Diffusion-Relaxation Matrix: DRM). DRM simultaneously provides diffusion tensor imaging and T
2 map without prolongation of acquisition time. This quantitative combination may be helpful to further assess the lumbar nerve root pathology.}
}
@inproceedings{ISMRM2018_5400,
annote={ISMRM2018_5400},
pages={5400},
file={ISMRM2018_5400.pdf:ISMRM2018_5400.pdf:PDF},
title={Quantitative {MR} Neurography with Robust Fat Suppression},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5400.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Masami Yoneyama and Akio Hiwatashi and Xinzeng Wang and Osamu Togao and Ivan E. Dimitrov and Ananth J. Madhuranthakam and Iain Ball and Marc Van Cauteren},
abstract={MR neurography plays a major role in the diagnostic work-up of peripheral nerve pathologies and a quantitative evaluation based on T
2 values can be clinically useful in estimating treatment effects and determining prognosis. Recently, we proposed a new sequence (SHINKEI-Quant) to add a quantitative information to MR neurography. To solve some issues caused by the current fat suppression techniques (SPAIR and STIR), we propose to combine SHINKEI-Quant with a new two-point dual-echo 3D DIXON-TSE (DE-mDIXON) technique. SHINKEI-Quant with DE-mDIXON simultaneously provides both MR neurography with high SNR, uniform fat suppression and T
2 maps with T
2 values similar to conventional method. This sequence may be helpful to quantitatively assess nerve pathology.}
}
@inproceedings{ISMRM2018_5401,
annote={ISMRM2018_5401},
pages={5401},
file={ISMRM2018_5401.pdf:ISMRM2018_5401.pdf:PDF},
title={Automatic delicate segmentation of the intervertebral discs from {MR} spine images using deep convolutional neural networks: {ICU}-net},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5401.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Sewon Kim and Won C Bae and Dosik Hwang},
abstract={The segmentation method using Deep Convolutional Neural Networks shows good performance in medical imaging. In particular, U-net is a well-known and successful model. However, U-net based on classification network shows weakness in fine segmentation. We developed a new model by changing layers and structure of U-net. Our model enables more detailed segmentation of the intervertebral discs in spine MR images.}
}
@inproceedings{ISMRM2018_5402,
annote={ISMRM2018_5402},
pages={5402},
file={ISMRM2018_5402.pdf:ISMRM2018_5402.pdf:PDF},
title={A longitudinal study of {APT} {CEST} contrast in the spinal cord of patients with multiple sclerosis at 3T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5402.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Richard Dylan Lawless and Quinn R Weinberg and Bailey Box and Samantha By and Francesca Bagnato and Seth A Smith},
abstract={Current clinical MRI sequences cannot characterize biochemical tissue changes within the spinal cord. Therefore, MRI biomarkers sensitive to biochemical tissue changes are needed. Amide proton transfer chemical exchange saturation transfer (APT CEST) is an emerging MRI contrast method sensitive to the exchange rate and concentration of amide proton moiety. In this work, we sought to assess the reproducibility and longitudinal change of spinal cord APT CEST in patients with MS. Our results suggest that APT CEST in the spinal cord is capable of reproducibly identifying underlying changes in spinal cord tissue pathology.}
}
@inproceedings{ISMRM2018_5403,
annote={ISMRM2018_5403},
pages={5403},
file={ISMRM2018_5403.pdf:ISMRM2018_5403.pdf:PDF},
title={Low Apparent Diffusion Coefficient Value Predicts Early Progression of Skull Base Meningiomas},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5403.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ching Chung Ko and Sher Wei Lim and Tai Yuan Chen and Jeon Hor Chen and Chien Feng Li and Yow Ling Shiue},
abstract={A recent study described the extent of tumor resection and ADC values could offer better prediction of progression/recurrence (P/R) in meningiomas than histopathological grading. Although complete resection of tumor is a key determining factor of recurrence in meningiomas, it is often difficulty to achieve for the skull base meningiomas (SBM) due to complex neurovascular structures. In this study, we investigated the preoperative CT and MR imaging features for the prediction of early P/R in SBM, with emphasis on ADC values. Our results found that low ADC value and adjacent bone invasion could predict high risk of early P/R in SBM and therefore, offer clinically vital information for the planning of treatment.}
}
@inproceedings{ISMRM2018_5404,
annote={ISMRM2018_5404},
pages={5404},
file={ISMRM2018_5404.pdf:ISMRM2018_5404.pdf:PDF},
title={In vivo 31P magnetic resonance spectroscopy of human parotid gland},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5404.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Toshiyuki Sato and Hiroyoshi Isoda and Hirotsugu Nakai and Shigeshi Kohno and Koji Tokunaga and Hironori Shimizu and Seiya Kawahara and Kaori Togashi},
abstract={This is the first in vivo study to investigate major phosphorus metabolites of human parotid gland with
31P magnetic resonance spectroscopy (MRS) using 3D chemical shift imaging (CSI) technique. Five healthy volunteers were measured on a clinical 3.0 T MRI scanner and three of them were remeasured immediately after intake of tablets containing vitamin C. The spectra reveal large adenosine triphosphate (ATP) and phosphocreatine (PCr) intensities. Following intake of tablets containing vitamin C, decrease of β-ATP can be observed. In vivo
31P MRS can be used to assess bioenergetics of the human parotid gland within a reasonable scan time.}
}
@inproceedings{ISMRM2018_5405,
annote={ISMRM2018_5405},
pages={5405},
file={ISMRM2018_5405.pdf:ISMRM2018_5405.pdf:PDF},
title={Detection of Spinal Cord Compression Injury in the Rat using Filter-Probe Diffusion Encoding},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5405.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Matthew Budde and Natasha Beucher and Seung Yi Lee and Brian Schmit and Shekar Kurpad},
abstract={A rat model of chronic spinal cord compression was evaluated with reduced field of view (rFOV) diffusion tensor imaging and filter-probe diffusion encoding. The results demonstrate the sensitivity of diffusion MRI for detecting injury.}
}
@inproceedings{ISMRM2018_5406,
annote={ISMRM2018_5406},
pages={5406},
file={ISMRM2018_5406.pdf:ISMRM2018_5406.pdf:PDF},
title={Anatomically-informed and patient-specific diffusion tensor sampling schemes for the cervical spinal cord},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5406.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Kurt Schilling and Samantha By and Quinn Weinberg and Bailey Box and Bennett A Landman and Adam W Anderson and Seth A. Smith},
abstract={In this study, we minimize uncertainty in Diffusion Tensor Imaging (DTI) parameters by optimally selecting diffusion gradient directions utilizing prior structural knowledge. By measuring the anatomy of the spinal cord for each subject, we created patient-specific, anatomically-informed DTI encoding schemes for 256 subjects, utilizing just 6 diffusion directions. In addition, we create an optimal encoding 6-direction scheme for the anatomically-average person. Through simulations and experimental validation on a physical fiber phantom, we show improvements in FA estimation, even when compared to conventional 30 direction schemes. This technique results in minimal scan time and increased accuracy in order to maximize clinical value.}
}
@inproceedings{ISMRM2018_5407,
annote={ISMRM2018_5407},
pages={5407},
file={ISMRM2018_5407.pdf:ISMRM2018_5407.pdf:PDF},
title={Oscillating Gradient Spin Echo ({OGSE}) Diffusion Tensor Imaging of the Human Spinal Cord: Application to Multiple Sclerosis},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5407.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Samantha By and Seth A. Smith and Kurt G. Schilling and Quinn Weinberg and Sean P. Devan and Francesca R. Bagnato and Junzhong Xu},
abstract={Compared to conventional pulsed gradient spin echo (PGSE) techniques, oscillating gradient spin echo (OGSE) provides access to shorter diffusion times, thereby enabling greater sensitivity to microstructure on smaller scales. Here, we report initial results of OGSE in the human spinal cord. Unlike in the brain, axial diffusivity in the spinal cord appears to be negligibly affected with diffusion time. Relative to the PGSE sequence (t
diff= 66 ms), the OGSE sequence (t
diff=8.77 ms) shows a 37\% mean increase in radial diffusivity (RD) in healthy controls. When applied to MS, OGSE shows a larger difference in RD in comparison to healthy controls.}
}
@inproceedings{ISMRM2018_5408,
annote={ISMRM2018_5408},
pages={5408},
file={ISMRM2018_5408.pdf:ISMRM2018_5408.pdf:PDF},
title={{MRI}-guided Focused Ultrasound to Improve Drug Delivery in Spinal Cord Injury},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5408.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Donna J. Cross and Allison H. Payne and Amanda J. Stump and Henrik Odéen and Megan A. Ostlie and Ethan C. Reichert and Chloe G. Cross and Yoshimi Anzai and Gregory W. Hawryluk},
abstract={Spinal cord injury (SCI) affects over 17,000 individuals each year in the United States and most patients are left with some permanent paralysis. MRI-guided focused ultrasound (MRgFUS), when applied to the spinal cord with microbubbles to generate sonoporation, can transiently open the blood spinal cord barrier for effective drug delivery by breaking the glial scar. We used MRgFUS to increase permeability in the blood spinal cord barrier in a SCI rat model. Rats that underwent an MRgFUS procedure showed increased contrast caudal to the injury site, indicating drugs could potentially permeate these regions and assist with axonal regrowth.}
}
@inproceedings{ISMRM2018_5409,
annote={ISMRM2018_5409},
pages={5409},
file={ISMRM2018_5409.pdf:ISMRM2018_5409.pdf:PDF},
title={Evaluation of a new semi-automatic delineation method for quantitative analysis of tumors: application to head and neck squamous cell carcinoma},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5409.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Kanae Moriyama and Hiroyuki Sugimori and Noriyuki Fujima and Toru Yamamoto},
abstract={Objective determination of tumor region of interest (ROI) on MR images is expected for quantitative analysis of tumors. We developed a semi-automatic method of ROI delineation. We applied this method to head and neck squamous cell carcinoma and evaluated the matching of the ROI delineation by our method and an experienced radiologist. The ADC values were compared for different ROI delineation methods. Averagely, 80\% of the area of the ROI matched and the difference of the ADC value was within 2\% (sd), showing that our new method of tumor delineation can be used to analyze the tumor characteristics quantitatively.}
}
@inproceedings{ISMRM2018_5410,
annote={ISMRM2018_5410},
pages={5410},
file={ISMRM2018_5410.pdf:ISMRM2018_5410.pdf:PDF},
title={Correlation of tumor blood flow in head and neck squamous cell carcinoma by pseudo-continuous arterial spin labeling with parameters of dynamic contrast-enhanced {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5410.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Young Jun Choi and Jeong Hyun Lee and Josef Pfeuffer},
abstract={The aim of this prospective study was to evaluate the correlation between tumor blood flow (TBF) measurement using pseudo-continuous arterial spin labeling (pCASL) and parameters of DCE-MRI in patients with head and neck squamous cell carcinoma (HNSCC). We scanned 26 patients with HNSCC using 3T MRI with both pCASL and DCE-MRI. There were significant correlation between TBF of pCASL and wash-in, signal enhancement ratio and Vp of DCE-MRI, with a correlation coefficient of 0.649, 0.642 and 0.507, respectively (P<0.01). The pCASL can be a useful tool for noninvasive assessments of the TBF in patients with HNSCC.}
}
@inproceedings{ISMRM2018_5411,
annote={ISMRM2018_5411},
pages={5411},
file={ISMRM2018_5411.pdf:ISMRM2018_5411.pdf:PDF},
title={Texture analysis applied to {MRI} of nerves affected with chronic inflammatory demyelinating neuropathy.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5411.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Paolo F Felisaz and Andrea Poli and Giovanni Vitale and Raimondo Vitale and Laura Piccolo and Andrea Cortese and Niels Bergsland and Anna Pichiecchio and Stefano Bastianello},
abstract={Introduction. Texture analysis was applied to MR images of peripheral nerves obtained with MR micro-neurography. Materials and Methods. Ankle tibial nerves were imaged at 3T in 10 patients affected with chronic inflammatory demyelinating neuropathy and 10 healthy subjects. Multiple subsets of textural features were compared, using different extraction methods and statistical analyses. The most discriminating features were selected and compared to the automatically extracted subsets. Results. Feature subset extracted from the whole pool of features performed better than the ones obtained by specific groups of features. Conclusion. Texture analysis may have a role in discriminating between pathologic and normal nerves.}
}
@inproceedings{ISMRM2018_5412,
annote={ISMRM2018_5412},
pages={5412},
file={ISMRM2018_5412.pdf:ISMRM2018_5412.pdf:PDF},
title={How to separate peripheral nerves from muscles},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5412.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ibrahim Ibrahim and Jaroslav Tintěra and Vít Herynek and Antonín Škoch and Ivan Humhej and Milan Hájek},
abstract={MR tractography of the peripheral nerves (PN) is challenging due to the difficulty to acquire high quality DWI data for peripheral nerve bundles reconstruction. The aim of this study was to propose an algorithm for separation LSP bundles from muscles using segmentaion of cauda equina and normalized quantitative anisotropy.}
}
@inproceedings{ISMRM2018_5413,
annote={ISMRM2018_5413},
pages={5413},
file={ISMRM2018_5413.pdf:ISMRM2018_5413.pdf:PDF},
title={Feasibility of Quantitative Diffusion {MR} Tractography of the Vestibulocochlear Nerve in Children with Unilateral Profound Sensorineural Hearing Loss},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5413.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ryan P Cabeen and Elina Kari and Courtney Voelkner and Marta Kulich and Laurel M Fisher and Yonggang Shi and Meng Law and Arthur W Toga},
abstract={Diffusion MR tractography modeling of the vestibulocochlear nerve (VCN) has clinical value for characterizing hearing loss and surgical planning for cochlear implants; however, the neuroanatomy of the VCN presents technical challenges to image-based modeling. We conducted a feasibility study to evaluate VCN tractography in children with unilateral sensorineural hearing loss using advanced diffusion MRI acquisitions and modeling techniques. The results indicate tractography of the VCN is clinically feasible and quantitative tractography metrics reflect lateralization of hearing loss. We further found significant improvements from a reverse-phase encoding acquisition and multi-shell multi-compartment diffusion modeling.}
}
@inproceedings{ISMRM2018_5414,
annote={ISMRM2018_5414},
pages={5414},
file={ISMRM2018_5414.pdf:ISMRM2018_5414.pdf:PDF},
title={Phantom Validation Study for Custom-made Orbit Surface Coil},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5414.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={ZONG RUI ZHANG and QING HUA CHEN and XIAO QI WANG and YAN TAO NIU and JUN FANG XIAN},
abstract={Previously introduced the new custom-made orbit imaging surface coil was tested in this research. The study gives a brief overview of the quantitative information that can be derived from it. Combining information from normal standard 15 channel head coil can aid in answering the typical advantages and future clinical application of the new surface coil. This phantom study is to verify the orbit surface coil’s feasibility in clinical use.
}
}
@inproceedings{ISMRM2018_5415,
annote={ISMRM2018_5415},
pages={5415},
file={ISMRM2018_5415.pdf:ISMRM2018_5415.pdf:PDF},
title={Working memory training and brain structural and functional correlates in children born preterm},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5415.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Claire Kelly and Deanne Thompson and Jian Chen and Elisha Josev and Leona Pascoe and Megan Spencer-Smith and Chris Adamson and Chiara Nosarti and Lex Doyle and Marc Seal and Peter Anderson},
abstract={In a randomised controlled trial, we investigated if adaptive, computerised working memory training using Cogmed was associated with greater neural changes compared with a placebo training program. Participants were a population-based cohort of 91 school-age children born <28 weeks’ gestation or <1000 g birthweight. Children had structural, diffusion and task-based functional MRI before and two weeks following five weeks of Cogmed or placebo. There was little evidence for larger changes in cortical morphometry, white matter microstructure, or brain functional activity following Cogmed compared with placebo. In our study, Cogmed did not benefit brain structure or function in preterm-born children.}
}
@inproceedings{ISMRM2018_5416,
annote={ISMRM2018_5416},
pages={5416},
file={ISMRM2018_5416.pdf:ISMRM2018_5416.pdf:PDF},
title={Early Identification of Reduced Brain Functional Connectivity in Very Preterm Infants with Motor Impairments},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5416.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Lili He and Hailong Li and Nehal Parikh},
abstract={Very preterm infants (<32 weeks gestational age) are at high risk for motor impairments. Investigation of brain network connectivity will improve our understanding of how brain organizational changes influence motor function and can result in improved individual risk stratification. In this work, we found reduction in functional connectivity in multiple motor and sensory regions, soon after birth, in very preterm infants at high risk of motor impairments assessed at 2 years of age. Our findings may enable mechanistic understanding and facilitate early, more accurate prediction of motor impairments.}
}
@inproceedings{ISMRM2018_5417,
annote={ISMRM2018_5417},
pages={5417},
file={ISMRM2018_5417.pdf:ISMRM2018_5417.pdf:PDF},
title={Prevalence of brain lesions in a contemporary cohort of newborns with complex congenital heart disease prior to surgery},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5417.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Christopher Kelly and Catarina Tristão Pereira and Sophie Arulkumaran and Lucilio Cordero Grande and Emer Hughes and Rui Pedro A. G. Teixeira and Johannes Steinweg and Joseph V Hajnal and John Simpson and A. David Edwards and Mary A Rutherford and Serena J Counsell},
abstract={Infants born with congenital heart disease (CHD) are known to experience a distinct pattern of neurodevelopmental and behavioural impairment in later life. In this study, we scanned 64 infants with complex CHD prior to surgery and used high-resolution structural, diffusion and susceptibility-weighted magnetic resonance imaging to understand the burden of brain lesions in a contemporary cohort. We characterised lesions and produced quantitative lesion maps, registered to a population template. We found a lower incidence of infarction than has been reported in previous comparable cohorts and we explore the clinical reasons that may explain such variation.}
}
@inproceedings{ISMRM2018_5418,
annote={ISMRM2018_5418},
pages={5418},
file={ISMRM2018_5418.pdf:ISMRM2018_5418.pdf:PDF},
title={Multicentre pediatric brain tumour dynamic susceptibility contrast ({DSC}-) {MRI} with contrast agent leakage correction},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5418.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Stephanie Withey and Jan Novak and Lesley MacPherson and Laurence Abernethy and Barry Pizer and Richard Grundy and Simon Bailey and Dipayan Mitra and Theodoros Arvanitis and Dorothee Auer and Shivaram Avula and Andrew Peet},
abstract={Dynamic susceptibility contrast (DSC-) MRI provides measures of relative cerebral blood volume (rCBV) in pediatric brain tumors. Correction of rCBV for the effects of contrast agent leakage can be done using post-processing techniques. Forty pediatric patients with high and low grade tumors underwent DSC-MRI scans pre-treatment at four centers. DSC-data was analyzed with and without leakage correction to calculate rCBV and the leakage parameter, K2. There were significant differences between all parameters when comparing the high and low grade tumor groups. Low grade tumors tended to show T1-dominant leakage effects while high grade tumors showed predominantly T2* dominance.}
}
@inproceedings{ISMRM2018_5419,
annote={ISMRM2018_5419},
pages={5419},
file={ISMRM2018_5419.pdf:ISMRM2018_5419.pdf:PDF},
title={Brain growth over the first 13 years of life in typically developing and very preterm children},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5419.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Deanne Thompson and Lillian Matthews and Bonnie Alexander and Katherine Lee and Claire Kelly and Rod Hunt and Jeanie Cheong and Megan Spencer-Smith and Marc Seal and Jeffrey Neil and Terrie Inder and Lex Doyle and Peter Anderson},
abstract={Few longitudinal cohort studies exist characterizing regional brain volumes from birth to adolescence. This study derives brain volumes in approximately 100 regions at term-equivalent, 7 and 13 years of age for 102 very preterm and 20 full-term children. The trajectory of brain development in many regions differed between very preterm and full-term children over the first 7 years of life. From 7 to 13 years brain growth slowed, ceased or regressed in both groups in a region-specific manner, apart from subcortical regions that continued to increase in volume. This study provides novel insights in typical and atypical regional brain volumetry.}
}
@inproceedings{ISMRM2018_5420,
annote={ISMRM2018_5420},
pages={5420},
file={ISMRM2018_5420.pdf:ISMRM2018_5420.pdf:PDF},
title={A simple semi-quantitative scale for brain {MR} imaging is associated with motor function, communication and cognition in dyskinetic cerebral palsy},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5420.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Olga Laporta-Hoyos and Simona Fiori and Kerstin Pannek and Julia Ballester-Plane and David Leiva and Lee B Reid and Alex M Pagnozzi and Elida Vázquez and Ignacio Delgado and Alfons Macaya and Roser Pueyo and Roslyn N Boyd},
abstract={Previous neuroimaging studies of DCP have been based on categorical descriptors or advanced neuroimaging protocols that cannot be easily utilised in a clinical context. To enable clinical translation, we characterized brain lesions and their association with clinical outcomes in 39 participants with DCP, using a semi-quantitative scale for brain MRI that is clinically accessible due to its relative simplicity and reliance only on standard clinical images. Our results indicate that (A) ventral posterior lateral thalamus and frontal lobe are the most frequent locations of observable lesions in DCP and that (B) sqMRI can index motor, communication and cognitive functioning.}
}
@inproceedings{ISMRM2018_5421,
annote={ISMRM2018_5421},
pages={5421},
file={ISMRM2018_5421.pdf:ISMRM2018_5421.pdf:PDF},
title={Quantitative 1H Single Voxel Spectroscopy In Metachromatic Leukodystrophy Patients Treated With Haematopoietic Stem Cell Gene Therapy: Preliminary Results},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5421.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Paola Scifo and Pasquale Anthony Della Rosa and Matteo Canini and Francesca Fumagalli and Valeria Calbi and Andrea Falini and Alessandro Aiuti and Cristina Baldoli},
abstract={The efficacy of Haematopoietic Stem Cell-Gene Therapy for Metachromatic Leukodystrophy is under evaluation. CNS damage is currently rated by means of visual MR severity scores. The aim of this study was to investigate whether quantitative spectroscopy measurements correlate with MR severity scores. This preliminary analysis shows that both NAA/Cr and NAA/Cho ratios are associated with progression in total MR Severity Score, Atrophy and Demyelination Load. This suggests that MR spectroscopy could be useful to longitudinally and quantitatively evaluate the disease burden in MLD patients.}
}
@inproceedings{ISMRM2018_5422,
annote={ISMRM2018_5422},
pages={5422},
file={ISMRM2018_5422.pdf:ISMRM2018_5422.pdf:PDF},
title={{FETAL} {CORTICAL} {PARCELLATION} {BASED} {ON} {GROWTH} {PATTERNS}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5422.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jing Xia and Caiming Zhang and Fan Wang and Oualid M. Benkarim and Gerard Sanroma and Gemma Piella and Miguel A. Gonzalez Ballester and Nadine Hahner and Elisenda Eixarch and Dinggang Shen and Gang Li},
abstract={The available cortical parcellations created for adults are inapplicable for fetuses, due to dramatic differences in brain appearances and dynamic growth of fetal brains. Considering sulcal-gyral landmarks are not stably established in fetal brains, we propose to use the growth patterns of cortical properties to parcellate fetal cortical surfaces. Growth patterns, which reflect underlying changes of microstructures, enable an accurate definition of distinct regions in development and function, as microstructures determine the molecular organization and functional principles of the cortex. We apply the growth-pattern-basedmethod on 25 normal fetuses from 26 to 29 gestational weeks and generated biologically meaningful parcellations.}
}
@inproceedings{ISMRM2018_5423,
annote={ISMRM2018_5423},
pages={5423},
file={ISMRM2018_5423.pdf:ISMRM2018_5423.pdf:PDF},
title={Fetal T1 mapping using multi-inversion {EPI} at 3T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5423.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Borjan Gagoski and Daniel Joseph Park and Ville Renvall and Esra Abaci-Turk and Elfar Adalsteinsson and Thomas Witzel and Lawrence L. Wald and Patricia Ellen Grant and Jonathan Polimeni},
abstract={T
1 mapping of the fetal brain is hindered by substantial, frequent and random fetal motion, making many current quantitative techniques impractical in the fetus. We have applied to the fetal brain (and adult brain for validation purposes) a recently introduced T
1 mapping technique based on EPI readout that is preceded by a non-selective inversion pulse and where the order of the acquired slices is permuted from one inversion recovery to the next, allowing efficient, high temporal sampling of the T
1 relaxation curve. We believe that this method is capable of providing accurate T
1 maps of the fetal brain.}
}
@inproceedings{ISMRM2018_5424,
annote={ISMRM2018_5424},
pages={5424},
file={ISMRM2018_5424.pdf:ISMRM2018_5424.pdf:PDF},
title={Chemotherapy reduces microstructural asymmetry in the brain},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5424.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Junyu Guo and Yuanyuan Han and Yimei Li and Wilburn E. Reddick},
abstract={Previously, we discovered two types of brain microstructural asymmetry: myelin-related asymmetry and axon-related asymmetry in healthy volunteers. In this study, we found that chemotherapy with methotrexate significantly reduced the microstructural asymmetries in patients with acute lymphoblastic leukemia, having a greater impact on asymmetries in younger patients than in older ones. Our results indicate that chemotherapy may lead to atypical brain development long before patients become symptomatic. These results may help to provide insights into neurocognitive deficits caused by chemotherapy.}
}
@inproceedings{ISMRM2018_5425,
annote={ISMRM2018_5425},
pages={5425},
file={ISMRM2018_5425.pdf:ISMRM2018_5425.pdf:PDF},
title={The Impact of Prenatal Endocrine-Disrupting-Chemical Exposure on Brain Function in Teenagers},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5425.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Chi-Ieong Hong and Shu-Li Wang and Chao-Yu Shen and Jeng-Dau Tasi and Tou-Rong Chen and Jun-Cheng Weng},
abstract={The products made by endocrine disrupting chemicals (EDCs) widely exists in our daily life, which could be a risk of our health. We tried to find the relationship between prenatal exposure to EDCs’ concentrations and teenager’s brain function using resting-state functional MRI (rs-fMRI). Our results showed the correlation between prenatal perfluorononanoic acid (PFNA)/MeHg exposure and functional alterations of the teenage brain in caudate gyrus and putamen.}
}
@inproceedings{ISMRM2018_5426,
annote={ISMRM2018_5426},
pages={5426},
file={ISMRM2018_5426.pdf:ISMRM2018_5426.pdf:PDF},
title={Assessment of myelination in developing brains by using the inhomogeneous magnetization transfer {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5426.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Xianjun Li and Yuli Zhang and Fan Wu and Xiaoqian Jia and Xiaoyu Wang and Chao Jin and Qinli Sun and Heng Liu and Xiaocheng Wei and Jian Yang},
abstract={In vivo assessment of myelination is critical for understanding the typical and pathological brain development. Inhomogeneous magnetization transfer (ihMT) has been proposed recently and may be useful to quantify myelin contents. This study tried to evaluate performances of magnetization transfer ratio (MTR) and ihMT ratio (ihMTR) in assessing the myelination of toddler and adolescent brains. The ihMTR maps hold larger image contrasts than MTR maps. Moreover, ihMTR demonstrates larger relative changes during the period from the toddler to adolescent. Results in this study suggested that ihMTR was specific for characterizing white matter and sensitive to myelination during the brain development.}
}
@inproceedings{ISMRM2018_5427,
annote={ISMRM2018_5427},
pages={5427},
file={ISMRM2018_5427.pdf:ISMRM2018_5427.pdf:PDF},
title={White Matter Integrity in Adolescents with Attention Deficit Hyperactivity Disorder with Comorbid Bipolar Disorder assessed by Tract Based Spatial Statistics},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5427.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Arzu Ceylan Has and Mahmut Mujdeci and Gokce Nur Say and Hediye Pinar Gunbey and Nilufer Okumus and Yusuf Karaer and Halime Tuna Cak Esen and Ozlem Yildiz Gundogdu and Rahsan Gocmen and Yonca Anik},
abstract={White matter (WM) integrity is an important factor for the pathophysiology of attention-deficit/hyperactivity disorder (ADHD) and bipolar disorder (BD) in adolescents. In this study, we hypothesized that adolescents with attention deficit hyperactivity disorder with comorbid bipolar disorder (ADHD+BD) would yield different pattern and extent of WM abnormalities than ADHD and BD. Sixty adolescents were categorized into four groups as ADHD, BD, ADHD+BD and healthy controls. The comparative diffusion tensor imaging analyses were performed between each patient group and healthy controls. Adolescents with ADHD+BD displayed different pattern and extent of WM abnormalities than ADHD and BD revealed by tract-based spatial statistics.}
}
@inproceedings{ISMRM2018_5428,
annote={ISMRM2018_5428},
pages={5428},
file={ISMRM2018_5428.pdf:ISMRM2018_5428.pdf:PDF},
title={Late post-natal brain metabolic changes in healthy rats, a longitudinal in vivo 1H and 31P {MRS} study},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5428.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Veronika Rackayova and Olivier Braissant and Rolf Gruetter and Valerie McLin and Cristina Cudalbu},
abstract={New-born rats are known to undergo important brain metabolic changes during first 4-5 weeks of their lives. However precise description of metabolic changes at latter stages is missing. At this period rats might still undergo changes due to final brain maturation what may impact data interpretation of experiments during this window. This study aimed to explore possible metabolic changes in the rat brain during the late post-natal period (post-natal days 29 - 77), using in-vivo
1H and
31P-MRS and a temporal resolution of 1 week. We report significant changes in Ins, tCho (mainly due to GPC increase), Tau and Glu in rats considered as young adults.}
}
@inproceedings{ISMRM2018_5429,
annote={ISMRM2018_5429},
pages={5429},
file={ISMRM2018_5429.pdf:ISMRM2018_5429.pdf:PDF},
title={Automated Extraction of the Fetal Brain from Functional {MRI} Data},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5429.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Saige E Rutherford and Mike Angstad and Jasmine Hect and Andre Zapico and Moriah Thomason and Chandra Sripada},
abstract={In this study, we present a novel application of a Convolution Neural Network algorithm to a challenging image segmentation problem: fetal brain segmentation. Resting-state fMRI data was obtained from 192 fetuses (gestational age 20-40 weeks, M=31.9, SD=4.28). The output from automated extractions are compared with the ground truth of manually drawn brain masks. We report that automated fetal brain localization and extraction is achievable at the same integrity of manual methods, in a fraction of the time.}
}
@inproceedings{ISMRM2018_5430,
annote={ISMRM2018_5430},
pages={5430},
file={ISMRM2018_5430.pdf:ISMRM2018_5430.pdf:PDF},
title={In vivo
1H {NMR} spectroscopy study of mitochondrial pyruvate carrier 1 ({MPC}1) deficient mouse reveals energy shift in the development of embryonic brain},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5430.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Hongxia Lei and Zeinab Ammar and Corina M Berset and Jean-Claude Martinou},
abstract={Pyruvate degradation is an important step for oxidative phosphorylation. We studied brains of murine embryos devoid of mitochondrial pyruvate carrier 1 (MPC1) using
1H MRS. We demonstrates that after the embryonic energy shift, lactate accumulation can explain embryonic lethality in embryo devoid of MPC1.}
}
@inproceedings{ISMRM2018_5431,
annote={ISMRM2018_5431},
pages={5431},
file={ISMRM2018_5431.pdf:ISMRM2018_5431.pdf:PDF},
title={Differential effects of hunger and depression on cerebral blood flow in healthy adolescents},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5431.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Céline Charroud and Emmanuelle Le Bars and Emily Sanrey and Jérémy Deverdun and Josef Pfeuffer and Nicolas Menjot de Champfleur and Philippe Coubes},
abstract={This study aims to explore the appetite effect on taste and depression on healthy adolescents using Arterial Spin Labeling. Fifteen participants complete the Multiscore Depression Inventory for Children test and two MRI sessions: pre-lunch (hunger) and post-lunch (satiety). We found an increased CBF – cerebral blood flow – during hunger in the posterior insula (anticipation and motivation of feeding) and during satiation in the precuneus, lingual gyrus and cuneus (inhibition pattern of food intake). We show that the correlations between depression and CBF are modulated by appetite in the precuneus, operculum, lingual, cuneus, middle frontal gyrus and inferior parietal lobule.}
}
@inproceedings{ISMRM2018_5432,
annote={ISMRM2018_5432},
pages={5432},
file={ISMRM2018_5432.pdf:ISMRM2018_5432.pdf:PDF},
title={Influences of the Gut Microbiome on Early Brain Development},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5432.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Douglas C Dean and Elizabeth M Planalp and Nicholas Vogt and Kristin Dowe and Alysha Rameshk and Kristine Mclaughlin and Abigail Freeman and Andrew L Alexander},
abstract={Increasing evidence from animal studies suggests the gut microbiome has a significant role on early brain development and function. However, little is known about this role on human brain development and in particular, on myelination. Using quantitative multicomponent relaxometry and 16S rRNA sequencing, we examined measures of myelin content and the gut microbiome from a cohort of typical developing infants. Infant brain measures were found to be differentially associated with the relative abundancies of certain bacteria phylum, suggesting that microbial communities may have a significant influence on processes of early brain development.}
}
@inproceedings{ISMRM2018_5433,
annote={ISMRM2018_5433},
pages={5433},
file={ISMRM2018_5433.pdf:ISMRM2018_5433.pdf:PDF},
title={Establishing a developmentally appropriate f{MRI} paradigm for presurgical mapping of memory in children},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5433.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Amanda G Wood and Elaine Foley and Parnpreet Virk and Helen Ruddock and Paras Joshee and Kelly Murphy and Stefano Seri},
abstract={The use of functional MRI to evaluate risk to memory function following temporal lobe surgery in children cannot rely on adult tools. We present a novel fMRI paradigm that is brief, independent of reading ability and therefore a candidate for presurgical evaluation. Data from 36 adults and 19 children (all healthy controls) show that the paradigm captures the expected leftward asymmetry of mesial temporal activation in adults. A more symmetrical pattern is observed in children, consistent with the emergence of hemispheric specialisation across childhood. These data have important implications for the interpretation of presurgical memory fMRI in the paediatric setting.}
}
@inproceedings{ISMRM2018_5434,
annote={ISMRM2018_5434},
pages={5434},
file={ISMRM2018_5434.pdf:ISMRM2018_5434.pdf:PDF},
title={Trajectories of brain lactate and energy metabolite concentrations do not contribute to elevated aerobic glycolysis across childhood},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5434.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Helene Benveniste and Gerald Dienel and Zvi Jacob and Hedok Lee and Rany Makaryus and Albert Gjedde and Fahmeed Hyder and Douglas L. Rothman},
abstract={Lactate is produced in normal brain even when O
2 levels are ample and high lactate production may explain aerobic glycolysis (AG) in developing brain. We evaluated steady state lactate concentrations ([Lac]) in brains of 87 children using 1HMRS while they underwent routine MRI examination. The trajectory of [Lac] in cerebral cortex across childhood was below the 0.5-0.7 mM range in normal adult brain. Thus, lactate accumulation and efflux are unlikely to underlie excessive AG in children.}
}
@inproceedings{ISMRM2018_5435,
annote={ISMRM2018_5435},
pages={5435},
file={ISMRM2018_5435.pdf:ISMRM2018_5435.pdf:PDF},
title={Potential role of diffusion tensor imaging in assessing neonatal neurobehavior development in the newborn stage},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5435.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Chao Jin and Xianjun Li and Congcong Liu and Yannan Cheng and Miaomiao Wang and Jian Yang},
abstract={Maturation of brain structure underpins its functionality. From birth, brain structure and neurobehavior abilities progressively mature. However, specific link between these two entities remains unclear. This study therefore aims to investigate such correlation between neonatal neurobehavior and brain white matter (WM) microstructural development measured by diffusion tensor imaging (DTI)-fractional anisotropy (FA). Results indicated that neonatal behavior abilities significantly correlated with sensorimotor WM FAs; while active-tone just correlated with motor-associated WM. These findings demonstrate the specialized correlations of specific neurobehavior abilities with microstructural maturation in corresponding WMs, suggesting the potential role of DTI in assessing the neonatal neurodevelopment in clinical practice.}
}
@inproceedings{ISMRM2018_5436,
annote={ISMRM2018_5436},
pages={5436},
file={ISMRM2018_5436.pdf:ISMRM2018_5436.pdf:PDF},
title={Quantifying cerebral hemodynamics in developing children using multiple post-labeling delay pseudo-continuous arterial spin labeling},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5436.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Nick Todd and Helen Santoro and Haley McEvoy and Danny JJ Wang and Lino Becerra and David Borsook and Duncan J Hodkinson},
abstract={Arterial Spin Labeling (ASL) is an attractive option for studies in pediatric populations due to its ability to acquire quantitative cerebral perfusion measurements without ionizing radiation. Brain vascular dynamics in children are different from adults and rapidly changing with age. ASL sequence parameters must therefore be carefully chosen and longitudinal studies must account for normally occurring neurodevelopment. Here we present a multiple-post label delay pseudo-continuous ASL approach to quantifying cerebral blood flow, arterial transit time and cerebral blood volume in children. We show analysis of the PLD selections with respect to ATT values and test-retest reliability of the CBF measurements.}
}
@inproceedings{ISMRM2018_5437,
annote={ISMRM2018_5437},
pages={5437},
file={ISMRM2018_5437.pdf:ISMRM2018_5437.pdf:PDF},
title={Changes in Resting-State Functional Brain Activity are Correlated with Waning Cognitive Functions in Pediatric {HIV}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5437.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Santosh K Yadav and Rakesh K Gupta and Sheema Hashem and Ajaz A Bhat and Ravindra K Garg and Vimala Venkatesh and Pradeep K Gupta and Alok K Singh and Muhammad W Azeem and Deepak Kaura and Mohammad Haris},
abstract={We evaluated the functional brain changes in HIV-infected children by mapping the amplitude-of-low-frequency-fluctuations (ALFF) and functional connectivity (FC) using rs-fMRI. Association of these changes with cognitive measures was also explored. ALFF and FC were significantly altered in multiple brain regions involved in auditory, visual, language, motor and sensory activity. The waning cognitive functions in HIV-infected children were associated with the changes in ALFF and FC. These two imaging parameters in association with the cognitive evaluation may provide better understanding of the functional brain activity in HIV-infected children.
}
}
@inproceedings{ISMRM2018_5438,
annote={ISMRM2018_5438},
pages={5438},
file={ISMRM2018_5438.pdf:ISMRM2018_5438.pdf:PDF},
title={Using Virtual Conjugate Coil reconstruction for statistical improvement in highly accelerated Simultaneous Multislice f{MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5438.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Adam O. Kettinger and Petra Hermann and Pal Vakli and Martin Blaimer and Kawin Setsompop and Stephan A. R. Kannengiesser and Felix A. Breuer and Zoltan Vidnyanszky},
abstract={Simultaneous multislice EPI is a popular acquisition method for high-temporal-resolution fMRI. However, at high acceleration factors, significant noise amplification could occur that can hinder the detection of activation. Using the Virtual Conjugate Coil concept, the g-factors of such measurements can be reduced. In this work we investigate the potential statistical improvement of using Virtual Conjugate Coil reconstruction in simultaneous multislice fMRI. Our results show that using Virtual Conjugate Coil reconstruction, first-level and group-level t-values, as well as first-level effect sizes and temporal signal-to-noise ratio are increased.}
}
@inproceedings{ISMRM2018_5439,
annote={ISMRM2018_5439},
pages={5439},
file={ISMRM2018_5439.pdf:ISMRM2018_5439.pdf:PDF},
title={Spiral f{MRI} using the Gradient Impulse Response Function for Trajectory Prediction},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5439.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Nadine N Graedel and Lars Kasper and Maria Engel and Jennifer Nussbaum and Bertram J Wilm and Klaas P Pruessmann and S Johanna Vannesjo},
abstract={Image artifacts resulting from gradient imperfections remain a challenge in spiral functional MRI. In this work we reconstructed spiral fMRI data using trajectories predicted by the gradient impulse response function (GIRF). The GIRF-reconstruction generates image quality and fMRI results similar to using a fully monitored trajectory. The presented approach requires only a one-time calibration per system, thus the fMRI acquisition is not prolonged or complicated by the acquisition of additional data for correction purposes.}
}
@inproceedings{ISMRM2018_5440,
annote={ISMRM2018_5440},
pages={5440},
file={ISMRM2018_5440.pdf:ISMRM2018_5440.pdf:PDF},
title={Gain of temporal signal-to-noise ratio with pTx universal pulses and the whole-brain f{MRI} 3D-{GE} {EPI} sequence at 7T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5440.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Vincent Gras and Alexandre Vignaud and Cécile Rabrait-Lerman and Denis Le Bihan and Tony Stoecker and Ruediger Stirnberg and Nicolas Boulant},
abstract={The volumetric 3D-EPI sequence has already shown great promise for fMRI studies due to potentially increased temporal SNR (tSNR) and lower energy demands compared to 2D multi-slice acquisition schemes. For whole-brain studies the tSNR yet can suffer from sub-optimal flip angles due to RF inhomogeneity. Parallel transmission (pTx) has been shown to be a very powerful technology to mitigate these effects but has been barely used in routine due to a cumbersome calibration procedure. Here, we use Universal Pulses to skip entirely the latter step and increase locally the tSNR at 7T in the 3D-EPI GE sequence.}
}
@inproceedings{ISMRM2018_5441,
annote={ISMRM2018_5441},
pages={5441},
file={ISMRM2018_5441.pdf:ISMRM2018_5441.pdf:PDF},
title={High {SNR} Functional {MRI} Using Oscillating Steady State Imaging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5441.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Shouchang Guo and Douglas C. Noll},
abstract={Signal-to-noise ratio (SNR), a limiting factor for functional MRI, can be improved by through the use of higher magnetic fields or through the use of array coils. This work proposes a novel acquisition scheme for BOLD fMRI that has the potential to improve SNR by a factor of 2 or more. This approach uses an oscillating steady state signal that is T2*-weighting and when combined across the period of oscillation produced robust fMRI results in both 2D and 3D imaging experiments.}
}
@inproceedings{ISMRM2018_5442,
annote={ISMRM2018_5442},
pages={5442},
file={ISMRM2018_5442.pdf:ISMRM2018_5442.pdf:PDF},
title={Effect of optimised coil-combinations on high-resolution laminar f{MRI} at 9.4T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5442.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Sriranga Kashyap and Francisco J. Fritz and Robbert L. Harms and Laurentius Huber and Dimo Ivanov and Alard Roebroeck and Benedikt A. Poser and Kâmil Uludağ},
abstract={Despite the availability of more sophisticated coil-combination methods like Roemer and STARC, ultra-high field fMRI studies still use the conventional sum-of-squares (SoS) method for combining the images of the individual coils from multi-channel RF-coil arrays. Here we use a memory-efficient, CPU/GPU accelerated coil-combine toolbox written in Python to compare and characterise the effect of methods such as covariance-weighted sum-of-squares (CovSoS), Roemer and STARC on sub-millimetre resolution GE-EPI laminar fMRI data acquired at 9.4T and demonstrate the benefit of using optimised coil-combination for UHF fMRI studies.}
}
@inproceedings{ISMRM2018_5443,
annote={ISMRM2018_5443},
pages={5443},
file={ISMRM2018_5443.pdf:ISMRM2018_5443.pdf:PDF},
title={Distortion-matched high-resolution reduced-FoV functional and diffusion {MRI} of the human brainstem at 7T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5443.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Giovanni Savini and Fabrizio Fasano and Joseph Whittaker and Letizia Casiraghi and Fulvia Palesi and Gloria Castellazzi and Alessandro Lascialfari and Egidio D'Angelo and Derek Jones and Richard Wise and Claudia Angela Gandini Wheeler-Kingshott},
abstract={The brainstem plays a key role in the central nervous system, but its proximity to the oral cavity and physiological noise sources constitute major limitations for EPI imaging. We compared image quality from full and reduced-FoV spin-echo EPI sequences at ultrahigh field. Compared to standard EPI acquisitions, reduced-FoV techniques confer considerable benefits for brainstem imaging in terms of shortening TE, increasing signal-to-noise ratio and mitigating distortions. We exploited these advantages for 7T distortion-matched functional and diffusion imaging of the brainstem using ZOOM-EPI. A finger tapping task resulted in significant activations in regions corresponding to the cuneate nucleus and the pyramidal decussation.}
}
@inproceedings{ISMRM2018_5444,
annote={ISMRM2018_5444},
pages={5444},
file={ISMRM2018_5444.pdf:ISMRM2018_5444.pdf:PDF},
title={Enhanced f{MRI} Using a Novel 3D Ultrafast Gradient-echo-based Sequence Using Spatiotemporal Encoding.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5444.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={JaeKyun Ryu and Won Beom Jung and Jeong Pyo Son and Seong-gi Kim and Jang-Yeon Park},
abstract={We recently introduced a novel ultrafast 3D gradient-echo-based imaging technique using spatiotemporal encoding (SPEN), which was dubbed RASE (Rapid Acquisition with Sequential Excitation). RASE has less sensitivity to field inhomogeneities and susceptibility differences compared to conventional multi-slice GE-EPI, sharing the advantages of 3D imaging such as high signal-to-noise ratio and high spatial resolution. In this preliminary study, we present very promising results of RASE-II fMRI, i.e., better t-scores, tSNR and BOLD percent-signal-changes than conventional multi-slice GE-EPI, on a 9.4-T animal scanner.}
}
@inproceedings{ISMRM2018_5445,
annote={ISMRM2018_5445},
pages={5445},
file={ISMRM2018_5445.pdf:ISMRM2018_5445.pdf:PDF},
title={Human Connectome Project ({HCP})-style resting state functional {MRI} at 7 Tesla using {RF} parallel transmission},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5445.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Xiaoping Wu and Edward J. Auerbach and Steen Moeller and Pierre-Francois Van de Moortele and Essa Yacoub and Kamil Ugurbil},
abstract={A major component of the Human Connectome Project (HCP) in the WU-Minn consortium is slice-accelerated whole-brain resting-state functional MRI (rfMRI) at both 3T and 7T. Although providing better contrast and higher spatial resolution, the 7T acquisition is compromised by RF nonuniformity. Here, we demonstrate how RF parallel transmission (pTx) can be used to improve RF uniformity for highly-accelerated, HCP-style rfMRI at 7T with simultaneous multislice multiband approach. Our results demonstrate that the combination of pTx with the 8-channel transmit/32-channel receive coil (Nova8Tx/32Rx) enhanced functional contrast-to-noise ratio (fCNR) in most cortical surfaces and subcortical voxels relative to the original HCP protocol utilizing the Nova1Tx/32Rx in combination with dielectric padding. The enhanced fCNR in turn yielded higher correlation values in seed-based connectivity measures. These results demonstrate that pTx provides significant gains in whole-brain rfMRI employed for defining the functional connectome of the human brain.}
}
@inproceedings{ISMRM2018_5446,
annote={ISMRM2018_5446},
pages={5446},
file={ISMRM2018_5446.pdf:ISMRM2018_5446.pdf:PDF},
title={Dual reconstructions of {SLIDER}-{XD} for high spatial and temporal resolution resting state f{MRI} at 7T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5446.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={An Thanh Vu and Alexander Beckett and David Feinberg and Pratik Mukherjee},
abstract={Here we assert that the individual dithers of a SLIDER-XD dataset can be utilized in a dual fashion to reconstruct not only a high spatial resolution dataset but also a high temporal resolution dataset (termed SLIDER-XDT) suitable for fMRI experiments requiring faster TRs. While analogous to spatial smoothing where spatial resolution is traded for statistical power in post-processing, SLIDER-XDT not only provides additional statistical power but also additional temporal resolution which can be used to support detection of additional resting state networks or to temporally un-alias signals of interest.}
}
@inproceedings{ISMRM2018_5447,
annote={ISMRM2018_5447},
pages={5447},
file={ISMRM2018_5447.pdf:ISMRM2018_5447.pdf:PDF},
title={StImulus Locked K-space shuffling ({SILK}) for ultra-high resolution f{MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5447.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={An Thanh Vu and Alexander Beckett and David Feinberg and Pratik Mukherjee},
abstract={Traditional EPI fMRI methods for acquiring sub-mm ultra-high resolution images require longer echo trains, resulting in SNR losses due to longer TEs, as well as, increased blurring in the phase encode (PE) direction, geometric distortion and susceptibility dropout. StImulus Locked K-space shuffling or SILK-fMRI (e.g. in the context of 3D FLASH imaging) does not suffer from the above limitations but has never before been applied to fMRI. Here we demonstrate the feasibility of SILK fMRI vs. traditional EPI for 0.35 mm ultra-high resolution fMRI at 7T.}
}
@inproceedings{ISMRM2018_5448,
annote={ISMRM2018_5448},
pages={5448},
file={ISMRM2018_5448.pdf:ISMRM2018_5448.pdf:PDF},
title={Multi-Band-Accelerated T2*-Weighted Inner-Field-of-View {EPI} of the Human Spinal Cord with Slice-Specific z-Shimming},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5448.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jürgen Finsterbusch},
abstract={T2*-weighted EPI suffers from severe signal dropouts and geometric distortions in the human spinal cord due to susceptibility differences between tissue, vertebrae and vertebral bones. With 2D-selective RF (2DRF) excitations, the field-of-view can be focused to the spinal cord without aliasing which reduces geometric distortions, shortens echo times and increases the signal-to-noise ratio significantly. Here, this approach is accelerated with simultaneous multi-slice (SMS) imaging to shorten the acquisition time. An individual temporal shift was applied to the different bands of a multi-band 2DRF envelope which corresponds to a slice- or band-specific z-shim that compensates for the specific through-slice dephasing effects.}
}
@inproceedings{ISMRM2018_5449,
annote={ISMRM2018_5449},
pages={5449},
file={ISMRM2018_5449.pdf:ISMRM2018_5449.pdf:PDF},
title={Optimising the detection of subcortical auditory function using f{MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5449.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Rebecca Susan Dewey and Deborah A Hall and Hannah Guest and Garreth Prendergast and Christopher J Plack and Susan T Francis},
abstract={We explore the effects of EPI distortion correction and retrospective correction of cardiac and respiratory artefacts on fMRI data quality. Further, we assess the suitability of this data to provide robust detection of subcortical sound-evoked responses for inter-group and subgroup analyses. We report an optimum acquisition, pre-processing and analysis protocol for subcortical fMRI of the ascending auditory pathway.}
}
@inproceedings{ISMRM2018_5450,
annote={ISMRM2018_5450},
pages={5450},
file={ISMRM2018_5450.pdf:ISMRM2018_5450.pdf:PDF},
title={Block-Interleaved Segmented {EPI} for voxel-wise high-resolution f{MRI} studies at 7T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5450.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Guoxiang Liu and Adnan Shah and Takashi Ueguchi},
abstract={We report a novel segmented EPI method preserving the pattern of hemodynamic response in bock design fMRI studies. The proposed method uses an EPI-based anatomical data obtained with the same distortion from task EPI scans for further fMRI analysis. At sub-millimeter spatial resolution, the proposed method avoids functional to structural registration and spatial smoothing giving us an opportunity to investigate activity dynamics at the columnar level spatial resolution with high specificity. Our results showed that the proposed method can perform voxel-wise high-resolution fMRI studies with a voxel size of 0.6×0.6×0.6 mm
3 at 7T.}
}
@inproceedings{ISMRM2018_5451,
annote={ISMRM2018_5451},
pages={5451},
file={ISMRM2018_5451.pdf:ISMRM2018_5451.pdf:PDF},
title={f{MRI} with Low Acoustic Noise using Variable-Blipped {EPI} with Readout Segmentation},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5451.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Patrick Liebig and Robin Heidemann and Yuehui Tao and Bernhard Hensel and Wei Liu and David Porter},
abstract={Echo-Planar-Imaging is widely used for fMRI, but generates a high level of acoustic noise This could potentially affect activation power, especially for auditory experiments. One established way to reduce acoustic noise is to use a sinusoidal readout gradient combined with a constant phase-encoding gradient. However, this data-sampling scheme is only suitable for lower acceleration factors. This study investigates an alternative EPI sampling scheme with similar acoustic-noise properties that can be used with high acceleration factors in both phase-encoding and slice-encoding directions. Acoustic noise is further reduced by using readout segmentation to reduce the readout gradient amplitude and slew rate.}
}
@inproceedings{ISMRM2018_5452,
annote={ISMRM2018_5452},
pages={5452},
file={ISMRM2018_5452.pdf:ISMRM2018_5452.pdf:PDF},
title={Real-time processing of image and trajectory data: Application to single-shot time series},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5452.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Josip Marjanovic and Jonas Reber and Maria Engel and Lars Kasper and Benjamin E. Dietrich and David O. Brunner and Klaas P. Pruessmann},
abstract={The steady increase in data volume is a significant problem in fMRI time series. Recently proposed signal processing architectures based on digital hardware enable data reduction in real-time before the data are stored. We demonstrate that a high degree of data savings can be achieved with few simple operations. Coil compression and field probe data processing help breaking the data bottleneck in fMRI time-series.}
}
@inproceedings{ISMRM2018_5453,
annote={ISMRM2018_5453},
pages={5453},
file={ISMRM2018_5453.pdf:ISMRM2018_5453.pdf:PDF},
title={Enhanced {BOLD} Contrast-to-Noise-Ratio and Activation Sensitivity with the Intra-shot Adapted Keyhole ({ISAK}) Method},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5453.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Zhan Xu and Guangyu Chen and Andrew S Nencka and Shi-Jiang Li},
abstract={A fast, multi-echo (ME) fMRI acquisition method, ISAK, is introduced by employing the classic keyhole method in a between-echo manner. ISAK acquires eight echoes within 70 ms and the associated contrast-to-noise-ratio (CNR) improvement is up to more than 200\%. The stronger blood-oxygen-level-dependent sensitivity, compared with regular ME fMRI with four echoes and standard single-echo fMRI without any acceleration, proves the benefit of trading a fraction of spatial samples in each image for more temporal echoes images in improving CNR.}
}
@inproceedings{ISMRM2018_5454,
annote={ISMRM2018_5454},
pages={5454},
file={ISMRM2018_5454.pdf:ISMRM2018_5454.pdf:PDF},
title={{THE} {ANGULAR} {DEPENDENCE} {OF} {THE} {GRADIENT} {ECHO} {AND} {SPIN} {ECHO} {BOLD} {SIGNAL} {INDUCED} {BY} {CORTICAL} {MICRO}- {AND} {MACRO}- {VASCULATURE}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5454.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Mario Gilberto Báez-Yáñez and Philbert S. Tsai and David Kleinfeld and Klaus Scheffler},
abstract={In recent investigations, the angular dependence of the BOLD signal with respect to the main magnetic field has been shown by Monte Carlo simulations and experimental approaches. This orientation dependence is often attributed to the contribution of large vessels (cortical surface and penetrating arteries/veins). However, the ability to resolve cortical layers and columns depends ultimately on the contribution of the MR signal generated by the capillary bed. In this work, we studied the MR signal attenuation generated by a vascular network model that was acquired from the parietal cortex of mice using a two-photon laser imaging techniques. We separately investigated the impact of macrovessels (>5 µm in diameter) and microvessels (< 5 µm in diameter) on the BOLD effect.}
}
@inproceedings{ISMRM2018_5455,
annote={ISMRM2018_5455},
pages={5455},
file={ISMRM2018_5455.pdf:ISMRM2018_5455.pdf:PDF},
title={Regional-specific echo-time optimization in spin-echo {EPI} at 3 Tesla},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5455.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Josephine Tan and Don M Ragot and J. Jean Chen},
abstract={Spin-echo (SE) echo-planar imaging (EPI) is less prone to signal dropouts in brain regions of high susceptibility. Such regions are important for the study of memory and language and have been traditionally difficult to image using the conventional gradient-echo BOLD fMRI. To maximize the contrast-to-noise of SE EPI, echo-time (TE) optimization is critical and currently, the optimal TE is assumed to be equal to tissue T2. In this work, we use a comprehensive BOLD signal and noise model to characterize the TE dependence of SE-EPI at 3 T. We show that the optimal TE is significantly shorter than the commonly assumed tissue T2.}
}
@inproceedings{ISMRM2018_5456,
annote={ISMRM2018_5456},
pages={5456},
file={ISMRM2018_5456.pdf:ISMRM2018_5456.pdf:PDF},
title={A comprehensive investigation of physiologic noise modeling in resting state f{MRI}; phase shifted cardiac response function in {EPI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5456.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Wanyong Shin and Mark J Lowe},
abstract={The cardiac and respiratory response functions derived from RETROICOR have substantial variation. In this study, we investigate the source of this variation. We found the cardiac response function is phase or time shifted across the brain while the respiratory function has a fixed phase, but changes polarity across the brain. We further investigated the efficacy of physiologic noise correction accounting for this with a single response function model.}
}
@inproceedings{ISMRM2018_5457,
annote={ISMRM2018_5457},
pages={5457},
file={ISMRM2018_5457.pdf:ISMRM2018_5457.pdf:PDF},
title={Novel multi-slab {GRASE} sequences for f{MRI}. Comparison with {EPI}.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5457.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Djaudat Idiyatullin and Wei Zhu and Yi Zhang and Xiao-Hong Zhu and Wei Chen and Kâmil Uğurbil},
abstract={T2 weighted fMRI has been shown to provide higher spatial specificity than commonly used T2* contrast. However, 2D-spin-echo-EPI method, which is the most commonly employed approach, suffers from a low functional mapping contrast. Versions of single-shot 3D-GRASE sequence provide improvements in fMRI contrast, but suffer limitations particularly at ultrahigh magnetic fields due to shorter T2. To solve this problem, a new multi-slab version of the 3D-GRASE sequence with and without the capability of inner-volume selection, abbreviated as ivmsGRASE and msGRASE, respectively, are proposed. The theoretical and practical considerations of these methods in comparison with spin-echo-EPI for fMRI application are presented.}
}
@inproceedings{ISMRM2018_5458,
annote={ISMRM2018_5458},
pages={5458},
file={ISMRM2018_5458.pdf:ISMRM2018_5458.pdf:PDF},
title={Velocity Selective Inversion improves the sensitivity and speed of perfusion weighted {FMRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5458.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Luis Hernandez-Garcia and Jon-Fredrik Nielsen and Douglas Noll},
abstract={This work compares the performance of pseudo-continuous ASL (PCASL) and velocity selective inversion ASL (VSI) for functional MRI using a simple, robust visual motor task. VSI showed increased sensitivity and allowed faster temporal resolution, resulting in further increases in sensitivity.}
}
@inproceedings{ISMRM2018_5459,
annote={ISMRM2018_5459},
pages={5459},
file={ISMRM2018_5459.pdf:ISMRM2018_5459.pdf:PDF},
title={Inter-site {MRI} scanner resolution and stability variance revealed by {EPI} f{MRI} phantom scans: a multi-site Canadian study},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5459.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={M. Aras Kayvanrad and Aditi Chemparathy and Stephen Arnott and Fan Dong and Mojdeh Zamyadi and Tom Gee and Robert Bartha and Christopher Scott and Sandra Black and Sean Symons and Glenda MacQueen and Jacqueline Harris and Andrew Davis and Geoffrey Hall and Stefanie Hassel and Stephen Strother},
abstract={The Ontario Neurodegenerative Disease Research Initiative (ONDRI) and the Canadian Biomarker Integration Network in Depression (CAN-BIND) are multisite longitudinal studies that employ 12 MRI scanners across Canada (6 in CAN-BIND) to collect neuroimaging data. To ensure comparability of neuroimaging data collected at different sites, fBIRN (functional Biomedical Informatics Research Network) phantoms have been scanned approximately monthly at each site for more than two years to obtain quality assurance (QA) measures from the fBIRN pipeline. In this abstract we present our investigations into within- and between-site variations due primarily to differences in full-width-at-half-maximum (FWHM) measures of imaging resolution.}
}
@inproceedings{ISMRM2018_5460,
annote={ISMRM2018_5460},
pages={5460},
file={ISMRM2018_5460.pdf:ISMRM2018_5460.pdf:PDF},
title={Correcting for the influence of cerebrospinal fluid in quantification of R2’ and deoxygenated blood volume ({DBV}) using quantitative {BOLD}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5460.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Matthew T Cherukara and Alan J Stone and Michael A Chappell and Nicholas P Blockley},
abstract={Streamlined qBOLD (sqBOLD) can be used to quantify deoxygenated blood volume and the reversible relaxation rate R2’ (used to estimate oxygen extraction fraction), although it is vulnerable to systematic errors from a number of confounding factors including the presence of cerebrospinal fluid (CSF). A FLAIR inversion preparation is typically used to null the CSF signal, but this results in a reduction in SNR and increases scan time. We present a post-processing method to account for the presence of CSF that has the potential to improve both the accuracy and efficiency of the sqBOLD technique without the need for FLAIR preparation.}
}
@inproceedings{ISMRM2018_5461,
annote={ISMRM2018_5461},
pages={5461},
file={ISMRM2018_5461.pdf:ISMRM2018_5461.pdf:PDF},
title={Rapid 3D Blipped Spiral f{MRI} at 7 T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5461.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Lars Kasper and Maria Engel and Christoph Barmet and Jonas Reber and Jakob Heinzle and Klaas Enno Stephan and Klaas Paul Pruessmann},
abstract={We present 3D blipped spiral fmri at 7T with a fast TR of 0.54s. Compared to 2D spirals, the 3D nature allows parallel imaging in z direction and blipped sampling of multiple planes that accelerate acquisition time, while the inherent averaging of multiple shots retains sufficient SNR. Intershot field inconsistency due to breathing and trajectory changes due to gradient heating in this high duty cycle sequence are compensated by NMR probe-based concurrent field monitoring, recovering high image quality and tSNR. We show the feasibility for fmri with 3D blipped spirals in a visual paradigm.
}
}
@inproceedings{ISMRM2018_5462,
annote={ISMRM2018_5462},
pages={5462},
file={ISMRM2018_5462.pdf:ISMRM2018_5462.pdf:PDF},
title={Mouse auditory pathway mapping using {BOLD} f{MRI} coherence analysis},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5462.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Cristina Chavarrias and Guilherme Blazquez Freches and Noam Shemesh},
abstract={The feasibility and potential of mapping the mouse auditory system through functional magnetic resonance imaging (fMRI) in mice was recently demonstrated. The goal of this work was to compare the conventional GLM analysis, which relies on the variability across regions of the haemodynamic response, with a coherence analysis, which is data-driven and provides rich temporal information. Coherence amplitudes closely follow the pattern of the GLM maps, whereas the delay maps obtained from the coherence phase show different latencies even inside each ROI. This suggests the utility of coherence analysis for mapping the auditory pathway in-vivo.}
}
@inproceedings{ISMRM2018_5463,
annote={ISMRM2018_5463},
pages={5463},
file={ISMRM2018_5463.pdf:ISMRM2018_5463.pdf:PDF},
title={Improved detection of neuronal-related {BOLD} events of unknown timing with Multi-Echo Sparse Paradigm Free Mapping},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5463.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Cesar Caballero-Gaudes and Javier Gonzalez-Castillo and Peter A Bandettini},
abstract={This work introduces an extension of sparse paradigm free mapping (SPFM) for multiecho (ME) fMRI: ME-SPFM. Based on the ME-fMRI signal model and L1-norm regularized estimators, ME-SPFM produces voxel-wise estimates of time-varying changes in the transverse relaxation ($R_2^*$) and the net magnetization ($S_0$) without prior information about experimental paradigms. Our evaluations demonstrate that ME-SPFM significantly outperforms its SE counterpart in terms of sensitivity and specificity, nearly matching that of traditional model-based analyses. ME-SPFM’s ability to blindly detect individual events at the single-subject level makes it an ideal candidate to explore the time-varying nature of brain activity in experimentally unconstrained paradigms (naturalistic, resting-state) or clinical applications (detection of inter-ictal epileptic events).}
}
@inproceedings{ISMRM2018_5464,
annote={ISMRM2018_5464},
pages={5464},
file={ISMRM2018_5464.pdf:ISMRM2018_5464.pdf:PDF},
title={A comparison of distortion correction methods for {EPI} f{MRI} applied across three 7T platforms},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5464.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ian D Driver and Olivier Mougin and William T Clarke and Catarina Rua and Adrian Carpenter and Keith Muir and Stuart Clare and Susan T Francis and Richard G Wise and Richard Bowtell},
abstract={In preparation for a wider multi-site ‘travelling heads’ 7T fMRI study, we compare the performance of EPI distortion correction techniques for fMRI data across four sites, using three different 7T platforms. Specifically, we compare B
0-map and phase-encoding reversal methods, applied to both task and resting state fMRI data.}
}
@inproceedings{ISMRM2018_5465,
annote={ISMRM2018_5465},
pages={5465},
file={ISMRM2018_5465.pdf:ISMRM2018_5465.pdf:PDF},
title={Serial Correlations in f{MRI} Time-Series Arise from Non-Stochastic Signals Related to Brain Function},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5465.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Kaundinya Gopinath and Venkatagiri Krishnamurthy and K Sathian},
abstract={In this study, we first demonstrate using resting state fMRI (rsfMRI) “null” datasets, that serial correlation in fMRI time-series arises from non-stochastic signals (e.g., coordinated activity within brain function networks unrelated to the fMRI paradigm of interest). Using this principle, we then advance a method to obtain whitened GLM first-level analysis regression residuals in task fMRI studies, by accounting for non-stochastic brain signals through principal components analysis. Importantly, the proposed methods is insensitive to the temporal resolution of fMRI time-series, unlike conventional stochastic models of serial correlation, whose parameters have to be modified depending on fMRI scan-TR.}
}
@inproceedings{ISMRM2018_5466,
annote={ISMRM2018_5466},
pages={5466},
file={ISMRM2018_5466.pdf:ISMRM2018_5466.pdf:PDF},
title={Predicting Individual Task Performance From Resting State f{MRI}: Effects of Training Task Data Quality},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5466.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Alexander D. Cohen and Elizabeth Zakszewski and Yang Wang},
abstract={Resting state functional MRI (rs-fMRI) has been used to predict individual task activation by training a model to map rs-fMRI networks to task performance. This study used a multiband, multi-echo acquisition to collect motor task fMRI as training data. The effects of echo combination and denoising of the training-task data on rs-fMRI predictions were examined. Multi-echo task data resulted in increased predictive accuracy of the model. These results suggest the quality of the training-task data affects the accuracy of the prediction model.}
}
@inproceedings{ISMRM2018_5467,
annote={ISMRM2018_5467},
pages={5467},
file={ISMRM2018_5467.pdf:ISMRM2018_5467.pdf:PDF},
title={Predicting individual language task activation from resting state f{MRI} using a novel data-driven approach},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5467.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Elizabeth Zakszewski and Alexander Cohen and Oiwi Parker Jones and Saad Jbabdi and Yang Wang},
abstract={This study is aimed to apply a newly developed machine learning approach to predict individual language network based on the resting state functional MRI (rs-fMRI). Despite the presence of significant variability of language network across subjects, the predicated language maps match excellently with the language task fMRI derived activation maps at the individual level. Our results suggest that rs-fMRI can be used as a promising clinical tool for mapping language network by using the novel processing approach.}
}
@inproceedings{ISMRM2018_5468,
annote={ISMRM2018_5468},
pages={5468},
file={ISMRM2018_5468.pdf:ISMRM2018_5468.pdf:PDF},
title={An automated method for assessing the accuracy of cross-modal registration in high-field f{MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5468.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Cheryl A Olman and Kimberly B Weldon and Andrea N Grant and Philip C Burton and Essa Yacoub},
abstract={In this work, we developed a method for evaluating the quality of cross-modal registration of functional and anatomical MRI datasets that obviates the need for subjective human judgments. In brief, we propose that the overlap of an activation mask derived from the functional data with a binary GM mask derived from the reference anatomical volume is a useful metric for overall registration quality. In addition, we promote the use of activation consistency throughout the gray matter as an inclusion criterion for regions of interest when computing laminar (depth-dependent) profiles, provided that the activation is computed in a robust, independent localizer.}
}
@inproceedings{ISMRM2018_5469,
annote={ISMRM2018_5469},
pages={5469},
file={ISMRM2018_5469.pdf:ISMRM2018_5469.pdf:PDF},
title={A comparison between amplitude of low frequency fluctuation calculation methods based on R2* signal and traditional T2*-weighted signal},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5469.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Li-Xia Yuan and Li-Sha Yuan and Hong-Jian He and Jian-Hui Zhong and Yu-Feng Zang},
abstract={The amplitude of low frequency fluctuation (ALFF) is usually computed from T2*-weighted functional MRI (fMRI) signals, which is affected by R2* fluctuation, echo time, spin density and mean R2*. To make ALFF more comparable and reliable between researches, we proposed a new method of ALFF calculation based on R2* (ALFF-R2*) in this work and further implemented for multi-echo fMRI. Statistical results from eyes-open and eyes-closed fMRI datasets show that ALFF-R2* detected an overall smaller significant regions than traditional ALFF in the paired T maps. The dice similarity coefficient between T maps from ALFF-R2* and traditional ALFF was 0.37. ALFF-R2* is potential to provide more specific results than traditional ALFF.}
}
@inproceedings{ISMRM2018_5470,
annote={ISMRM2018_5470},
pages={5470},
file={ISMRM2018_5470.pdf:ISMRM2018_5470.pdf:PDF},
title={Comparison of the functional correlation tensor under eyes closed and eyes open conditions},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5470.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yang Fan and Jing Wang and Bing Wu},
abstract={Recently, a novel technique was proposed directly integrated resting-state fMRI and DTI techniques to construct a local spatio-temporal correlation tensor from resting state fMRI data, termed as the functional correlation tensor. Previous studies demonstrated that resting-state fMRI properties varied from different resting conditions, such as eyes closed, eyes open and fixation. However, whether the functional correlation tensor will be affected by different baseline conditions is still need to be investigated. In this study, group-level properties of the functional correlation tensor were assessed and compared under eyes closed and eyes open conditions.}
}
@inproceedings{ISMRM2018_5471,
annote={ISMRM2018_5471},
pages={5471},
file={ISMRM2018_5471.pdf:ISMRM2018_5471.pdf:PDF},
title={Using Hierarchical Clustering Method to Reveal the Formation of Sub-groups among Subjects at Frontal Cortex in f{MRI} study with Complex Natural Stimulus},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5471.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jacky, Tai-Yu Lu and Yi-Tien Li and Yi-Cheng Hsu and Fa-Hsuan Lin},
abstract={The inter-subject correlation (ISC) analysis which is widely used in functional magnetic resonance imaging (fMRI) studies with complex natural stimulus design. It has been reported that relatively lower ISC value at higher cognitive brain areas could be inferred for individual variability. This study proposed the hierarchical clustering analysis method to discover the formation of sub-groups which showed positive correlation within the sub-group members but negative or non-correlation between the sub-groups among subjects. We found that the existence of sub-groups among whole subjects rather than non-correlation at frontal cortex. The synchronized brain activity could be found at frontal cortex within each sub-group.}
}
@inproceedings{ISMRM2018_5472,
annote={ISMRM2018_5472},
pages={5472},
file={ISMRM2018_5472.pdf:ISMRM2018_5472.pdf:PDF},
title={Multi-site reliability of Default Mode Network and Graph Theoretical Measures in Resting State f{MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5472.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Sumra Bari and Pratik Kashyap and Kausar Abbas and Brenna C. McDonald and Thomas M. Talavage},
abstract={This study investigated the multi-site reliability of resting state fMRI (rs-fMRI) using Default Mode Network (DMN) connectivity and graph theory measures like mean shortest path distance, clustering coefficient, modularity, transitivity and global mean strength. Test-retest and between-site reliability for all metrics were calculated by variance component analysis using restricted maximum likelihood (REML) estimates. Test-retest reliability was found to be poor to fair and between-site reliability was consistently poor for all metrics.}
}
@inproceedings{ISMRM2018_5473,
annote={ISMRM2018_5473},
pages={5473},
file={ISMRM2018_5473.pdf:ISMRM2018_5473.pdf:PDF},
title={Accurate modelling of temporal correlations in rapidly sampled f{MRI} time series using “{FAST}”.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5473.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Nadège Corbin and Nick Todd and Karl J Friston and Martina F Callaghan},
abstract={Accurate estimation of the temporal correlations that exist in fMRI time-series is essential in order to avoid a high false positive rate. A common approach is to pre-whiten data using an AR(1)+white noise model. However, this approach proves insufficient for repetition times (TR) <1.5s. An alternative is to expand the set of covariance components included in the model (of serial correlations), as in the “FAST” option implemented by SPM12. Here, we show that this model can be used to accurately pre-whiten rapidly sampled data and identify an upper bound on the parameterisation (i.e., number of covariance components) that precludes numerical overflow with ill-conditioned matrices. Such a model is important given the increasing use of rapid imaging techniques, such as multiband imaging. Using this technique, 18 components provided robust results with TR times ranging from 0.35s to 2.8s.}
}
@inproceedings{ISMRM2018_5474,
annote={ISMRM2018_5474},
pages={5474},
file={ISMRM2018_5474.pdf:ISMRM2018_5474.pdf:PDF},
title={A support vector machine-based method to identify non-neuropsychiatric systemic lupus erythematosus with Regional Homogeneity},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5474.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Xiangliang Tan and Zhuqing Long and Yingjie Mei and Wenjun Qiao and Kai Han and Yikai Xu},
abstract={Previous studies found that changes in brain function happened in default mode network beforeNeuropsychiatric involvement (NPSLE) development by using resting-state functional magnetic resonance imaging (rs-fMRI), highlighting the need for early evaluation and intervention in SLE patients. In this study, we proposed a valid Support Vector Machine (SVM) -based method to identify non-NPSLE using regional homogeneity (ReHo). The results demonstrate that ReHo parameter is an effective classification feature for the SVM-based method to identify SLE patients from healthy subjects.}
}
@inproceedings{ISMRM2018_5475,
annote={ISMRM2018_5475},
pages={5475},
file={ISMRM2018_5475.pdf:ISMRM2018_5475.pdf:PDF},
title={Temporal autocorrelation bias still exists in f{MRI} results},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5475.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Wiktor Olszowy and John Aston and Catarina Rua and Guy Williams},
abstract={Given the recent trend towards validating the neuroimaging methods, we compared the most popular fMRI analysis softwares: AFNI, FSL and SPM, with regard to autocorrelation modelling. We used both resting-state and task-based fMRI data, for which we assumed different experimental designs. For FSL and SPM we observed a strong relationship that the lower the assumed experimental design frequency, the more likely it was to observe significant activation. It indicates that pre-whitening in FSL and SPM does not remove a substantial part of the temporal autocorrelation in the noise. Our study points to superior autocorrelation modelling in AFNI.}
}
@inproceedings{ISMRM2018_5476,
annote={ISMRM2018_5476},
pages={5476},
file={ISMRM2018_5476.pdf:ISMRM2018_5476.pdf:PDF},
title={Complex-valued analysis of high-resolution {SSFP}-f{MRI} increases reliability in detecting active voxels},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5476.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Vahid Malekian and Arash Foroudi Ghasemabadi and Abbas Nasiraei Moghaddam},
abstract={In this study, we evaluated the reliability of the results of a complex-valued analysis that uses both magnitude and phase data in a SSFP-fMRItechnique. From the activation map of complex analysis and the corresponding magnitude one, we selected the common active voxels and calculated the average z-score over all of them. By observing an approximately 9.4\% increase of z-score in complex maps compared to magnitude ones, we can conclude that by using both magnitude and phase data we are able to increase the confidence and reliability of detecting active voxels. Therefore, complex analysis method can be promising in evaluating SSFP-fMRI methods.}
}
@inproceedings{ISMRM2018_5477,
annote={ISMRM2018_5477},
pages={5477},
file={ISMRM2018_5477.pdf:ISMRM2018_5477.pdf:PDF},
title={High Resolution f{MRI} Data De-noising Technique Using Spatio-Temporal Diffusion Filter},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5477.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Vahid Malekian and Abbas Nasiraei Moghaddam},
abstract={Diffusion-based filtering approaches are widely used in MR image de-noising literature but only a few studies, utilize this technique for fMRI applications. In these studies, 1D \& 2D diffusion filters were applied using temporal and spatial information separately. Here, a novel spatio-temporaldiffusion filtering method is proposed for high-spatial resolution fMRI data which has sufficient contrast between gray matter and other tissues. The results on the experimental SSFP data shows the ability of the proposed technique in improving functional sensitivity as well as preserving the edges of active regions in high-resolution fMRI techniques.}
}
@inproceedings{ISMRM2018_5478,
annote={ISMRM2018_5478},
pages={5478},
file={ISMRM2018_5478.pdf:ISMRM2018_5478.pdf:PDF},
title={A novel phase-based technique to reduce physiological noise in resting state f{MRI} data},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5478.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Vahid Malekian and Abbas Nasiraei Moghaddam and Daniel Gomez and Jose P. Marques and David G. Norris},
abstract={In this study, a novel phase-based technique is proposed to decrease the effects of physiological noise in resting-state fMRI data. Our technique is based on extracting nuisance components from the phase of fMRI data using spatial-ICA and utilize it to clean magnitude data. To evaluate, we performed the proposed method on Multi-Band fMRI data which benefits from higher temporal resolution to encode physiological effects and compare the efficacy of the technique both with magnitude-based and with RETRIOCOR techniques. Our method has marginal higher identifiability index and z-score’smean values compared to magnitude-based and RETROICOR methods.}
}
@inproceedings{ISMRM2018_5479,
annote={ISMRM2018_5479},
pages={5479},
file={ISMRM2018_5479.pdf:ISMRM2018_5479.pdf:PDF},
title={Fuzzy {GLM} approaches based on {LR} and alpha-cut representations for f{MRI} activity detection},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5479.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Alejandro Veloz and Steren Chabert and Alejandro Weinstein and Hector Allende and Claudio Moraga},
abstract={The General Linear Model (GLM) approach is still the standard paradigm used in routine fMRI analysis. This method is based on a model of the BOLD response which depends on the Hemodynamic Response Function (HRF). The HRF ignores the intrinsic intra- and inter-subject variability, resulting in inaccuracies in the brain activity detection. This work leverages on fuzzy sets theory with the purpose of developing a fuzzy GLM to overcome limitations of current GLM-based approaches. We performed an evaluation on simulated and in vivo fMRI data. We compare our results with aproaches based on dictionary learning and wavelet decomposition.}
}
@inproceedings{ISMRM2018_5480,
annote={ISMRM2018_5480},
pages={5480},
file={ISMRM2018_5480.pdf:ISMRM2018_5480.pdf:PDF},
title={Smooth global f{MRI} signals facilitate robust cross-subject classification of naturalistic movie stimuli},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5480.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Hendrik Mandelkow and Jacco de Zwart and Jeff Duyn},
abstract={The imprecision of anatomical alignment methods commonly limits the spatial resolution and sensitivity of conventional fMRI analysis based on statistical parametric mapping. Recently proposed machine-learning methods aim to circumvent the cross-subject (XS) alignment problem by computing a linear projection of the fMRI signal from each subject's anatomical space to a common albeit abstract "functional" space [1][2]. The success of these "hyperalignment" methods is often attributed to a spatially and functionally specific (linear) correspondence between the fMRI signal in different subjects under similar stimulation conditions. Cross-subject PCA of averaged fMRI data from repeated movie-viewing experiments reveals smooth globally distributed fMRI signal components that facilitate robust cross-subject classification by Linear Discriminant Analysis (LDA). Such global cortical network activity may contribute to the success of fMRI hyperalignment strategies.}
}
@inproceedings{ISMRM2018_5481,
annote={ISMRM2018_5481},
pages={5481},
file={ISMRM2018_5481.pdf:ISMRM2018_5481.pdf:PDF},
title={Can Sensitivity and Specificity Be Gained Simultaneously in Neuroimaging?},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5481.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Gang Chen and Yaqiong Xiao and Paul A Taylor and Fengji Geng and Tracy Riggins and Elizabeth Redcay and Robert W Cox},
abstract={Whole brain analysis currently faces two challenges: the increasing demand of correction for multiplicity and the usual tug of war between specificity and sensitivity. In addition, sensitivity suffers substantially because of stringent correction, while specificity is not directly considered when forming clusters. Specificity can be largely guaranteed through ROI-based analysis if ROIs can be a priori defined. Furthermore, sharing information across ROIs through an integrated model can improve model efficiency and detection power. We offer an alternative or complementary approach to the conventional methods in resolving the dilemma of multiple comparisons and dichotomous decisions. Lastly, through the approach, we promote totality and transparency in results reporting and avoid the hard thresholding of a p-value funnel.}
}
@inproceedings{ISMRM2018_5482,
annote={ISMRM2018_5482},
pages={5482},
file={ISMRM2018_5482.pdf:ISMRM2018_5482.pdf:PDF},
title={Frequency Characteristics of Blind-Deconvolved Resting-State Networks using Empirical Mode Decomposition},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5482.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Dietmar Cordes and Muhammad Kaleem and Xiaowei Zhuang and Karthik Sreenivasan and Zhengshi Yang and Tim Curran and Virendra Mishra},
abstract={Energy-period relationships and frequency content of Intrinsic Mode Functions (IMFs) were studied in deconvolved fMRI data using a blind deconvolution method. Results are shown for multiband MB8 resting-state data collected with a TR of 0.765s for a group of 22 healthy subjects. Findings of the present study suggest that high-frequency content in the major primary resting-state networks (such as the Default Mode Network, Visual Network, Auditory Network, or Fronto-Parietal network) is rather limited and not supported to be of any significance for high frequencies larger than 0.21 Hz, whether in BOLD data or blind-deconvolved data.}
}
@inproceedings{ISMRM2018_5483,
annote={ISMRM2018_5483},
pages={5483},
file={ISMRM2018_5483.pdf:ISMRM2018_5483.pdf:PDF},
title={{PCA} Based Noise Reduction of Delay Maps Obtained from Human Connectome Project Resting State f{MRI} Data},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5483.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Serdar Aslan and Blaise Frederick},
abstract={Previous work from our group has presented compelling evidence that systemic low frequency oscillations (sLFOs), the major constituent of low frequency global systemic noise overlying resting state functional networks, propagate dynamically throughout the brain with cerebral blood circulation. More specifically, it has been demonstrated that sLFOs travel with the bulk cerebral blood flow with voxel-specific arrival time delays and their spatiotemporal pattern changes in a way that tracks cerebral blood flow dynamics. We are interested in using the Human Connectome Project (HCP) dataset to determine normative blood flow delays throughout the brain. Time delay maps were obtained by the Regressor Interpolation at Progressive Time Delays (RIPTiDe) method , which was applied to 487 subjects of the HCP 500 subjects release data. While the procedure generates extremely clean mean delay maps, the individual delay maps are quite noisy. Because the circulation delays should in general be slowly varying in space, PCA noise reduction is a natural choice to preserve the spatial structure of the delay maps while removing random noise points.}
}
@inproceedings{ISMRM2018_5484,
annote={ISMRM2018_5484},
pages={5484},
file={ISMRM2018_5484.pdf:ISMRM2018_5484.pdf:PDF},
title={Multivariate Pattern Analysis of f{MRI} Data using Deep Neural Network},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5484.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yi-Cheng Wang and Jia-Ren Chang and Chia-Lin Chen and Ching-Ju Yang and Wei-Chi Li and Jen-Chuen Hsieh and Li-Fen Chen and Yong-Sheng Chen},
abstract={This paper presents a novel MVPA method based on deep neural networks, which can identify a group of voxels with their pattern of activity capable of differentiating experimental conditions. Through the forward inference procedure, the proposed deep neural network can also be applied to distinguish brain imaging data of different experimental conditions. Our experimental results suggest that deep neural networks are of great potential as an MVPA tool for functional brain mapping.}
}
@inproceedings{ISMRM2018_5485,
annote={ISMRM2018_5485},
pages={5485},
file={ISMRM2018_5485.pdf:ISMRM2018_5485.pdf:PDF},
title={Serotonergic Excitability and Functional Connectivity in Acute, Chronic and Withdrawal Phases of Antidepressant Treatment},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5485.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Horea-Ioan Ioanas and Bechara John Saab and Markus Rudin},
abstract={The serotonergic system is characterized by high centrality and is implicated in affective disorders and their treatment. During longitudinal antidepressant (fluoxetine) administration in mice, we optogenetically stimulate the ascending serotonergic system and infer brain activity via fMRI. We resolve serotonergic excitability and functional connectivity at 5 time points and show that a network representation is needed to adequately model the data. For acute and chronic sessions we document significantly increased serotonergic excitability and distinctly multivariate effects on serotonergic transmission. Finally, we find a full brain function recovery to baseline after fluoxetine withdrawal.
}
}
@inproceedings{ISMRM2018_5486,
annote={ISMRM2018_5486},
pages={5486},
file={ISMRM2018_5486.pdf:ISMRM2018_5486.pdf:PDF},
title={On the sensitivity of T1 mapping methods to myelin},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5486.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Damien Nguyen and Tobias Kober and Oliver Bieri},
abstract={For homogeneous and isotropic probes, different MR relaxometry methods are expected to yield consistent results. For tissues, however, wide-spread T
1 and T
2 relaxation times are reported in the literature. Especially in the brain, we hypothesize that the microstructure, e.g. the presence of myelin, affects the apparent observed T
1, as assessed by different imaging sequences. As a result, apparent differences in T
1 might reflect valuable information on the underlying tissue microstructure, such as myelination.}
}
@inproceedings{ISMRM2018_5487,
annote={ISMRM2018_5487},
pages={5487},
file={ISMRM2018_5487.pdf:ISMRM2018_5487.pdf:PDF},
title={Comparison of Inhomogeneous Magnetization Transfer (ih{MT}) and Myelin Water Fraction ({MWF}) In-Vivo at 3T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5487.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Irene Vavasour and Anastasia Smolina and Erin MacMillan and Guillaume Gilbert and Michelle Lam and Piotr Kozlowski and Carl Michal and Alan Manning and Cornelia Laule and Alex MacKay},
abstract={Inhomogeneous Magnetization Transfer (ihMT) shows promise as a myelin-specific MRI technique. Recent publications demonstrate that ihMT contrast is generated by long-lived dipolar couplings between protons on lipid molecules. We tested ihMT’s myelin specificity by comparing it to a more validated myelin measure, myelin water fraction (MWF), in 10 healthy volunteers. The ihMT ratio (ihMTR) correlated with MWF in white matter but MWF had a larger dynamic range. When MWF was zero, ihMTR was non-zero, supporting that ihMTR arises from all lipid molecules, not just those in myelin. ihMTR and MWF measure different and complementary, aspects of tissue structure.}
}
@inproceedings{ISMRM2018_5488,
annote={ISMRM2018_5488},
pages={5488},
file={ISMRM2018_5488.pdf:ISMRM2018_5488.pdf:PDF},
title={Acceleration strategies for whole brain quantitative Magnetization Transfer Imaging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5488.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Marco Battiston and Francesco Grussu and Torben Schneider and Ferran Prados and Sebastien Ourselin and Claudia Angela Wheeler-Kingshott and Rebecca Sara Samson},
abstract={Methods for quantitative measurement of myelin are of great interest for understanding brain tissue microstructure and have potentially important implications in clinical settings for improved diagnosis and prognosis in demyelinating diseases. Quantitative Magnetization Transfer (qMT) has been proposed as a sensitive MRI technique for myelin mapping in the central nervous system. However, after an initial wave of interest, it has never found a successful translation into a clinical scenario, mostly due to its prohibitive scan time. Here we investigate solutions to promote the development of fast qMT protocols including simultaneous multi-slice EPI and provide preliminary results in vivo.}
}
@inproceedings{ISMRM2018_5489,
annote={ISMRM2018_5489},
pages={5489},
file={ISMRM2018_5489.pdf:ISMRM2018_5489.pdf:PDF},
title={Accurate measurement of susceptibility and orientation using non-linear signal phase evolution; validation in a phantom experiment},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5489.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Elena Kleban and Richard Bowtell and Penny Gowland and Molly Bright},
abstract={We validate the use of non-linear signal phase evolution to estimate the susceptibility and orientation of sub-voxel structures. Capillary tubes filled with ferritin solutions of varying susceptibility were positioned in a water phantom. Multi-echo gradient-echo scans (100 echoes, echo-spacing=0.6ms) were acquired for multiple orientations of the capillaries with respect to the magnetic field. Fitting a 2-compartment model to the complex signal, processed using frequency difference mapping (FDM), resulted in susceptibility and signal fraction estimates in good agreement with theoretical predictions. Non-linear phase evolution, processed using FDM, may provide new insight into microvascular structure and physiology.}
}
@inproceedings{ISMRM2018_5490,
annote={ISMRM2018_5490},
pages={5490},
file={ISMRM2018_5490.pdf:ISMRM2018_5490.pdf:PDF},
title={7T {GRE}-{MRI} frequency shifts obtained from signal compartments can differentiate normal from dysplastic tissue in focal epilepsy},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5490.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Kiran Thapaliya and Markus Barth and Steffen Bollmann and David Reutens and Viktor Vegh},
abstract={Quantitative assessment of water fraction, relaxation time and frequency shift using a multi-compartment model can be useful in understanding diseases and disorders affecting the human brain. We aimed to explore tissue microstructure information contained in voxel signals by analysing voxel compartment water fraction, $T_2^*$ and frequency shift derived from 7T multi-echo gradient recalled echo MRI data. We recruited four patients with focal cortical dysplasia and compartmentalised normal and dysplastic cortical regions. Parameterisation of tissue characteristics in focal cortical dysplasia can potentially delineate cortical areas which have undergone microstructural changes. This provides a promising framework for studying neurodegenerative processes.}
}
@inproceedings{ISMRM2018_5491,
annote={ISMRM2018_5491},
pages={5491},
file={ISMRM2018_5491.pdf:ISMRM2018_5491.pdf:PDF},
title={Myelin water fraction across the corpus callosum using multi-echo gradient echo at 7T - influence of model settings and flip angle},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5491.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Kiran Thapaliya and Viktor Vegh and Steffen Bollmann and Markus Barth},
abstract={Proper quantitative assessment of myelin water fraction (MWF) using a multi-compartment model can be useful in improving our understanding of white matter diseases, however, MWF model estimates have been shown to be affected by model settings and also by T1 values of the myelin compartment. In this study, we investigated three common models using different number of parameters to assess MWF across the corpus callosum and the influence of acquisition flip angle at 7T.}
}
@inproceedings{ISMRM2018_5492,
annote={ISMRM2018_5492},
pages={5492},
file={ISMRM2018_5492.pdf:ISMRM2018_5492.pdf:PDF},
title={A procedure to scale myelin water fraction to myelin volume fraction for g-ratio mapping},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5492.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Woojin Jung and Hyeong-Geol Shin and Jingu Lee and Sooyeon Ji and Doohee Lee and Yoonho Nam and Jongho Lee},
abstract={In this study, we propose a new scaling approach that translates myelin water fraction into myelin volume fraction using the geometric property of myelin. The method is validated by a histo-imaging dataset. A computer simulation is performed to demonstrate the robustness of the method.}
}
@inproceedings{ISMRM2018_5493,
annote={ISMRM2018_5493},
pages={5493},
file={ISMRM2018_5493.pdf:ISMRM2018_5493.pdf:PDF},
title={Quantifying magnetic microstructure: Beyond the perturbative regime},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5493.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Pippa Storey and Dmitry S. Novikov},
abstract={We model the magnetic microstructure of tissue by a colloidal suspension of spherical beads, whose susceptibility differs from that of the surrounding medium. We show that length scale and susceptibility differences of the microstructure can be quantified with good accuracy by imaging the suspension with a multiple gradient echo sequence and fitting the signal as a function of echo time to the results of Monte Carlo simulations. By comparison, the second-order cumulant expansion used in deriving analytic expressions for the signal is a poor approximation at long echo times, even when the dephasing is relatively small over the correlation time.}
}
@inproceedings{ISMRM2018_5494,
annote={ISMRM2018_5494},
pages={5494},
file={ISMRM2018_5494.pdf:ISMRM2018_5494.pdf:PDF},
title={A Feasibility Study of Quantifying Renal Microvascular Diameter and Density Using Vessel Size Imaging ({VSI})},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5494.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Chengyan Wang and Hanjing Kong and Fei Gao and Li Jiang and Jue Zhang and Xiaoying Wang},
abstract={Information on renal microvascular architecture is still hardly accessible by clinical MRI techniques. This study explores the feasibility of using spin- and gradient-echo (SAGE) based dynamic susceptibility-contrast MRI for the quantification of renal microvascular diameter/density. Microvascular diameter (VSI) map, Q map and vessel density (D) map were calculated based on the differential dependence of R2/R2* relaxation rates on the capillary-sized vascular structures, which may provide a potentially important MR biomarker for the detection and staging of renal cell carcinoma}
}
@inproceedings{ISMRM2018_5495,
annote={ISMRM2018_5495},
pages={5495},
file={ISMRM2018_5495.pdf:ISMRM2018_5495.pdf:PDF},
title={The role of ferritin and myelin in orientation dependent R2* measured from susceptibility-weighted {MR} signal in white matter},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5495.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Daniel Kor and Jonathan Doucette and Tianyou Xu and Alexander Rauscher},
abstract={The R
2* relaxation in brain's white matter(WM) exhibits a dependency on WM fibre orientation relative to the external magnetic field, B
0. Here, we introduce a computational model based on first principles derived from magnetic field inhomogeneities generated by ferritin and myelin. We investigate their effects on the multi gradient-echo signal by fitting simulated R
2*, over angles 0–90
o, to experimental R
2*(R
2=0.94). By comparing different myelin concentrations, we present how ferritin is required to complement myelin in describing the orientation dependency in R
2*. Additionally, we propose a model for mapping R
2* as a function of fibre orientation, myelin and iron concentration.}
}
@inproceedings{ISMRM2018_5496,
annote={ISMRM2018_5496},
pages={5496},
file={ISMRM2018_5496.pdf:ISMRM2018_5496.pdf:PDF},
title={Dipolar relaxation time (T1D) mapping to assess myelin in vivo},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5496.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Victor N. D. Carvalho and Olivier M. Girard and Valentin H. Prevost and Samira Mchinda and Gopal Varma and David C. Alsop and Pierre Thureau and Guillaume Duhamel},
abstract={The dipolar relaxation time (T
1D) is related to motion restricted molecules and could be used to assess myelin molecular dynamics associated with physiopathology processes. T
1D was measured with the inhomogeneous magnetization transfer (ihMT). T
1D maps were obtained from in-vivo mouse brain and from ex-vivo rat spinal cord at different temperatures. T
1D was approximately 5ms in brain and 1.8ms in muscle. T
1D in spinal cord was doubled from 26°C to 37°C, reflecting changes in molecular dynamics caused by the temperature rise. Measuring T
1D in-vivo could give information about the myelin membrane structure altered in neurological disorders.}
}
@inproceedings{ISMRM2018_5497,
annote={ISMRM2018_5497},
pages={5497},
file={ISMRM2018_5497.pdf:ISMRM2018_5497.pdf:PDF},
title={Immunohistochemical validation of myelin water fraction obtained with {FAST}-T2 at 3 Tesla},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5497.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Thanh D Nguyen and Mayyan Mubarak and Somiah Dahlawi and Kelly M Gillen and David Pitt and Yi Wang},
abstract={The purpose of this study was to validate MWF measurements obtained by FAST-T2 at 3T by myelin basic protein (MBP) staining in a postmortem brain. Excellent correlation (R=0.98) was found between MWF and MBP relative optical density measurements.}
}
@inproceedings{ISMRM2018_5498,
annote={ISMRM2018_5498},
pages={5498},
file={ISMRM2018_5498.pdf:ISMRM2018_5498.pdf:PDF},
title={The Effect of Range of Echo Time on Gradient Echo Based Myelin Water Fraction Mapping},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5498.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Hongpyo Lee and Yoonho Nam and Dong-Hyun Kim},
abstract={Recently, myelin water fraction has been investigated using mGRE data. The purpose of this study is to investigate effects of the range of TE in GRE based MWF using different three fitting models. The results of simulation and in-vivo data suggest that complex model can be helpful to overcome bias due to susceptibility anisotropy compared to magnitude based models.}
}
@inproceedings{ISMRM2018_5499,
annote={ISMRM2018_5499},
pages={5499},
file={ISMRM2018_5499.pdf:ISMRM2018_5499.pdf:PDF},
title={In vivo high-field myelin water imaging: Investigating the T2 distribution at 7T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5499.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Vanessa Wiggermann and Alex L MacKay and Gunther Helms and Alexander Rauscher},
abstract={With the increased frequency of human 7T scanners, there is also a drive towards the implementation advanced MR sequences, such a myelin water imaging, at high fields. Here, we demonstrate the feasibility of translating 3T myelin acquisitions scheme, GRASE, to 7T. We studied the distribution of T
2 values at 7T and determined that myelin water has a T
2<25ms. We obtained excellent agreement for myelin water fraction values in the corpus callosum between 3T and 7T.}
}
@inproceedings{ISMRM2018_5500,
annote={ISMRM2018_5500},
pages={5500},
file={ISMRM2018_5500.pdf:ISMRM2018_5500.pdf:PDF},
title={robust principle component analysis (r{PCA}) in multi-echo gradient-echo imaging: application in visualizing myelin-related signal without exponential modeling.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5500.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jaewook Shin and Hongpyo Lee and Dong-Hyun Kim},
abstract={In white matter, it is possible to describe multi-echo gradient-echo (mGRE) signal as the summation of multiple exponential decays. However, fitting to this model is sensitive to the error in the raw mGRE signal. In this study, mGRE signal is decomposed to a low rank plus sparsity component using robust principle component analysis (rPCA). Through this, myelin-related signal was extracted without performing exponential modeling. The sparse signal showed myelin-like contrast similar to other mGRE based myelin water imaging.}
}
@inproceedings{ISMRM2018_5501,
annote={ISMRM2018_5501},
pages={5501},
file={ISMRM2018_5501.pdf:ISMRM2018_5501.pdf:PDF},
title={Varying diffusion effects in susceptibility-based myelin water imaging produce characteristic signal decay curves},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5501.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Felix T Kurz and Lukas R Buschle and Martin Bendszus and Christian H Ziener and Johann ME Jende},
abstract={The biophysical origins of MR signal formation in uniform media such as an axon with its multilayered myelin envelope may produce signal characteristics that can be used to determine status and/or outcome of demyelinating disease. We extend a recently proposed model of neuronal magnetic susceptibility by including the whole dynamic range of diffusion effects to study gradient-echo MR signal decay. Our results may be used to adjust or control simulation studies on neuronal MR signal decay.}
}
@inproceedings{ISMRM2018_5502,
annote={ISMRM2018_5502},
pages={5502},
file={ISMRM2018_5502.pdf:ISMRM2018_5502.pdf:PDF},
title={3D Steady-State Inhomogeneous Magnetization Transfer (ih{MT}) Gradient Echo Sequence for Spinal Cord Imaging at 3T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5502.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ece Ercan and Marco C. Pinho and Gopal Varma and Ivan E. Dimitrov and Xinzeng Wang and Ananth J. Madhuranthakam and Robert E. Lenkinski and Elena Vinogradov},
abstract={Inhomogeneous magnetization transfer (ihMT) is an enhanced magnetization transfer method, which is sensitive to dipolar couplings in white matter. Current spinal cord applications of ihMT use long saturation followed by single-slice acquisitions. As an alternative to this implementation, in our study we implemented and optimized a pulsed ihMT-prepared 3D gradient echo sequence for a larger coverage of spinal cord. The in vivo ihMT results from cervical spinal cord demonstrate potential for future applications of the ihMT in the spinal cord.}
}
@inproceedings{ISMRM2018_5503,
annote={ISMRM2018_5503},
pages={5503},
file={ISMRM2018_5503.pdf:ISMRM2018_5503.pdf:PDF},
title={3D inhomogeneous magnetization transfer and rapid gradient echo (ih{MTRAGE}) imaging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5503.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Gopal Varma and Olivier M Girard and Samira Mchinda and Arnaud Guidon and Dan W Rettmann and Victor Carvalho and Valentin H Prevost and Pauline W Worters and Marc R Lebel and Guillaume Duhamel and David C Alsop},
abstract={The inhomogeneous magnetization transfer (ihMT) technique provides a myelin-sensitive signal and has been applied for 3D acquisition in the steady-state. Sequences applied in a segmented fashion, following some magnetization preparation, provide an advantage of allowing insertion of additional modules, e.g. motion correction. An ihMT acquisition in the style of the magnetization-prepared rapid gradient-echo sequence was designed based on considerations of safety, hardware and optimizing the ihMT signal. Whole brain 3D ihMT data with 2.4mm isotropic resolution was achieved in 6-7mins. IhMT ratios between 15-20\% were measured in white matter areas and were not significantly modified by inclusion of a prospective motion correction module.}
}
@inproceedings{ISMRM2018_5504,
annote={ISMRM2018_5504},
pages={5504},
file={ISMRM2018_5504.pdf:ISMRM2018_5504.pdf:PDF},
title={The developmental dependence of the contrast between white and grey matter in spinal cord: the effect of non-aqueous species content},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5504.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Uzi Eliav and Peter J. Basser and Efrat Sasson and Gil Navon},
abstract={Recently an imaging pulse sequence based on selective saturation of the water that drives magnetization transfer from the non-aqueous semi-solid part of the tissues was introduced. This technique allows the estimation of the fraction of the protons in the non-aqueous species. It separates the exchange processes from T1 in a simple way. In the current study, using this technique, we demonstrate changes with age of the non-aqueous species content in porcine spinal cord.}
}
@inproceedings{ISMRM2018_5505,
annote={ISMRM2018_5505},
pages={5505},
file={ISMRM2018_5505.pdf:ISMRM2018_5505.pdf:PDF},
title={Quantifying the Myelin and Iron Contents of the Brain in vivo using a Linear Model of Relaxation},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5505.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Riccardo Metere and Harald E. Möller},
abstract={Quantitative MRI maps are believed to strongly correlate with myelin and iron contents. Recently, a linear model combining prior information from non-MRI techniques was proposed for quantifying myelin and iron based on relaxometry (R
1 and R
2*) in post-mortem human brain samples. Here, we propose an adaptation of the linear relaxation model that is capable of predicting (with some limitations) the myelin and iron contents of the brain under in vivo conditions. It uses prior knowledge from the literature to calibrate the linear coefficients and was validated in a cohort of 10 subjects.}
}
@inproceedings{ISMRM2018_5506,
annote={ISMRM2018_5506},
pages={5506},
file={ISMRM2018_5506.pdf:ISMRM2018_5506.pdf:PDF},
title={Investigation of tumor bed effect of radiotherapy using vessel size imaging in animal prostate cancer},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5506.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yu-Chun Lin and Fang-Hsin Chen and Gigin Lin and YI-Ping Lin and Ho-Kai Wang and Jiunjie Wang and Chun-Chieh Wang},
abstract={MR-derived estimates of vessel size and vascular density were used to investigate the microvasculature change of tumor following preirradiation on tumor bed. The hypoxic area exhibited higher vessel size and reduced microvascular density compared with those in normoxic area. The alterations of the derived estimates were more pronounced in hypoxic regions. Significantly positive correlations were found between MRI and histology measurements. The vessel size imaging technique may be used as an imaging biomarker to characterize the tumor bed effect that occurs in recurrent tumor after radiotherapy.}
}
@inproceedings{ISMRM2018_5507,
annote={ISMRM2018_5507},
pages={5507},
file={ISMRM2018_5507.pdf:ISMRM2018_5507.pdf:PDF},
title={Imaging white matter damage after traumatic brain injury: a high-field multimodal approach in a rat model},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5507.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Maria Yanez Lopez and Nicoleta Baxan and Cornelius Donat and Marc Goldfinger and Peter Hellyer and Mazdak Ghajari and Steve Gentleman and Magdalena Sastre and David Sharp},
abstract={The aim of this work was to study white matter microstructural and molecular changes in a rat model of TBI using CEST and multi-shell diffusion NODDI techniques. Our results suggest that the FA decrease after injury is mainly caused by an increase in fiber dispersion in the white matter, as seen with OD NODDI. MT decrease in the CC suggests an insult to the lipids in the myelin sheath and the NOE signal displays contributions from haemorrhage in the injury time point. Histology work will allow for a more accurate interpretation of the imaging results.}
}
@inproceedings{ISMRM2018_5508,
annote={ISMRM2018_5508},
pages={5508},
file={ISMRM2018_5508.pdf:ISMRM2018_5508.pdf:PDF},
title={Evaluating the use of Oxygen-Enhanced {MRI} with {ICA} to assess the tumour oxygenation status in murine tumour models},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5508.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Firas Moosvi and Jennifer H.E. Baker and Andrew Yung and Piotr Kozlowski and Andrew I. Minchinton and Stefan Reinsberg},
abstract={Want to assess the oxygenation status of tumours using non-invasive, contrast-agent free MRI? In this work we explore how OE-MRI can be used to extract and amplify signal from oxygen gas challenges in mouse tumours. With only dynamic T1-weighted images we can create rich oxygenation status maps that show high correlation with pimonidazole staining.}
}
@inproceedings{ISMRM2018_5509,
annote={ISMRM2018_5509},
pages={5509},
file={ISMRM2018_5509.pdf:ISMRM2018_5509.pdf:PDF},
title={Quantifying the Effect of Lipids’ Composition on Water Proton Relaxation},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5509.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Oshrat Shtangel and Aviv Mezer},
abstract={It’s a major challenge to localize and quantify molecular content in the human brain for in-vivo MRI clinical use. Here, we formulated liposomes to model the environment of abundant lipids in the brain. To investigate the influence of those lipids on relaxation we estimated multiple quantitative MRI (qMRI) parameters. Moreover, we assess the relationship between the lipids’ qMRI parameters and the water fraction (WF). Our findings show that joining multiple qMRI parameters with the WF introduces a novel possibility to separate between different lipids' mixtures. Extending this approach can potentially be used to identify molecular signatures of human tissue in-vivo.
}
}
@inproceedings{ISMRM2018_5510,
annote={ISMRM2018_5510},
pages={5510},
file={ISMRM2018_5510.pdf:ISMRM2018_5510.pdf:PDF},
title={Self-referenced {DCE}-{MRI}: reference region modelling without a reference tissue},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5510.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Zaki Ahmed and Ives R. Levesque},
abstract={Analysis of dynamic contrast enhanced (DCE) MRI using the reference region model (RRM) requires manual identification of a reference tissue, which is typically chosen as muscle external to the tissue of interest. The current work proposes an automated technique, named the self-reference approach, for finding a suitable reference-region curve from within the tissue of interest. This approach was evaluated on in-vivo data from glioblastoma and sarcoma patients and was found to be equally as effective as manual identification of the reference tissue in most cases and in some cases provides substantially improved fits.}
}
@inproceedings{ISMRM2018_5511,
annote={ISMRM2018_5511},
pages={5511},
file={ISMRM2018_5511.pdf:ISMRM2018_5511.pdf:PDF},
title={A reference region version of the two-compartment exchange model for {DCE}-{MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5511.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Zaki Ahmed and Ives R. Levesque},
abstract={This work proposes a version of the two-compartment exchange model (2CXM) for dynamic contrast enhanced MRI that does not require an arterial input function (AIF). Instead, the proposed model uses the tracer-concentration from a reference region, with the assumption that the AIF is shared between the reference region and tissue of interest. The proposed model was evaluated in simulation and in-vivo where it had comparable performance to the conventional 2CXM with temporal sampling faster than 10 s. With slower temporal sampling, the reference region version had better accuracy and precision than the conventional 2CXM.}
}
@inproceedings{ISMRM2018_5512,
annote={ISMRM2018_5512},
pages={5512},
file={ISMRM2018_5512.pdf:ISMRM2018_5512.pdf:PDF},
title={Support Vector Machine based Differentiation between Vasogenic Edema and Non-enhancing Tumor in High-Grade Glioma Patients using Pre and Post Surgery {MRI} Images},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5512.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Anirban Sengupta and Anup Singh and Sumeet Agarwal and Pradeep Kumar Gupta and Rakesh Kumar Gupta},
abstract={Differentiation of non-enhancing tumor from surrounding vasogenic edema is critical for planning tumor surgery as well as radiation therapy. Most studies suggested that histology results should be taken as ground truth instead of radiologist’s decision for validating results. This study is an attempt to differentiate vasogenic-edema from non-enhancing tumor based upon pre and post-surgery MRI images using a SVM classifier. DCE-MRI obtained perfusion parameters were used for classification. A misclassification error of 2.4 \% was obtained for differentiating between non-enhancing tumor and edema using a SVM classifier followed by smoothing in post-processing step.}
}
@inproceedings{ISMRM2018_5513,
annote={ISMRM2018_5513},
pages={5513},
file={ISMRM2018_5513.pdf:ISMRM2018_5513.pdf:PDF},
title={Effect of B1 Inhomogeneity propagated error of {DCE} {MRI} Data on Tumor Grading of Gliomas at 3T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5513.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Anirban Sengupta and Anup Singh and Rakesh Kumar Gupta and Pradeep Kumar Gupta},
abstract={DCE-MRI data is generally acquired using spoiled gradient Recalled(SPGR) echo sequence which is highly sensitive to B1 inhomogeneity. The error introduced due to B1 inhomogeneity effect on SPGR sequence is propagated to various perfusion parameters calculated in DCE-MRI. These parameters are used in various clinical analysis such as grading of tumor patients. This study had evaluated the change in perfusion parameters due to B1 inhomogeneity on 35 patients. Further simulations were done to evaluate its clinical significance. This study concluded that the change in perfusion parameters because of B1 inhomogeneity can change grading of glioma patients.}
}
@inproceedings{ISMRM2018_5514,
annote={ISMRM2018_5514},
pages={5514},
file={ISMRM2018_5514.pdf:ISMRM2018_5514.pdf:PDF},
title={Application of spin and gradient-echo ({SAGE}) sequence for renal perfusion imaging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5514.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Chengyan Wang and Hanjing Kong and Fei Gao and Li Jiang and Jue Zhang and Xiaoying Wang},
abstract={Quantification of absolute R2/R2* instead of the relative signal changes provides T1-independent perfusion imaging, which is beneficial for renal blood volume (RBV) estimations. This study applied the multiple spin- and gradient-echo (SAGE) sequence for renal perfusion imaging in ischemic acute kidney injury (AKI) animals. The results show that Both RBV and Tmax were significantly attenuated during the acute phase of AKI. R2/R2*-derived RBVs were significantly lower in the AKI kidney than that in the healthy contralateral kidney. Both R2-based and R2*-based perfusion imaging can be used to detect renal injury in AKI animals.}
}
@inproceedings{ISMRM2018_5515,
annote={ISMRM2018_5515},
pages={5515},
file={ISMRM2018_5515.pdf:ISMRM2018_5515.pdf:PDF},
title={Slice-Accelerated Gradient-Echo Echo-Planar Imaging: Feasibility and Utility of Isotropic Perfusion Imaging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5515.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yasuaki Tsurushima and Ryuji Nojiri and Takahiro Mihara and Keiichi Ishigame and Tomohiro Takamura and Masaaki Hori},
abstract={The purpose of this study was to investigate the feasibility and utility of isotropic perfusion maps obtained using multi-band (MB) single-shot echo-planar imaging (EPI) technique. We evaluated the quantitative equivalence between MB dynamic susceptibility contrast-enhanced (DSC) magnetic resonance imaging (MRI) and single-band (SB) DSC MRI, as well as the superiority of registration accuracy in isotropic MB-DSC MRI compared with anisotropic SB-DSC MRI. MB-DSC MRI yields isotropic perfusion maps that can improve the registration accuracy and multisection assessment by creating multiplane reconstruction, without deteriorating or altering the quantitative parameters.}
}
@inproceedings{ISMRM2018_5516,
annote={ISMRM2018_5516},
pages={5516},
file={ISMRM2018_5516.pdf:ISMRM2018_5516.pdf:PDF},
title={Robust {SNR} determination based on Resampling for Quality Control and Workflow Support in Quantitative {DCE} perfusion},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5516.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jakob Meineke and Karsten Sommer and Jochen Keupp},
abstract={A Monte-Carlo method is used to compute and predict SNR of image data for quantitative DCE-MRI perfusion measurements. This information can be used for quality assurance and to improve imaging workflow.}
}
@inproceedings{ISMRM2018_5517,
annote={ISMRM2018_5517},
pages={5517},
file={ISMRM2018_5517.pdf:ISMRM2018_5517.pdf:PDF},
title={Comparison of arterial input functions measured from dynamic contrast enhanced {MRI} and computed tomography in prostate cancer patients},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5517.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Shiyang Wang and Zhengfeng Lu and Xiaobing Fan and Milica Medved and Steffen Sammet and Xia Jiang and Ambereen Yousuf and Federico Pineda and Aytekin Oto and Gregory Karczmar},
abstract={Arterial input functions (AIFs) measured from dynamic contrast enhanced (DCE) MRI following low dose (0.015 mmol/kg) contrast media were compared with AIFs from DCE CT as ‘gold standard’. Twenty prostate cancer patients received CT and MRI scans on the same day. To correct for different temporal resolution and sampling periods, an empirical mathematical model was used to fit the AIFs and calculate numerical AIFs. Convolution was performed to correct for differences in CT and MRI injection times (~1.5s vs. 30s). MRI and CT AIFs were very similar. Therefore, AIFs can be accurately measured by MRI following low dose contrast agent injection.}
}
@inproceedings{ISMRM2018_5518,
annote={ISMRM2018_5518},
pages={5518},
file={ISMRM2018_5518.pdf:ISMRM2018_5518.pdf:PDF},
title={Spinal Cord Perfusion is Associated with Diffusion in Postoperative Patients with Cervical Spondylotic Myelopathy},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5518.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Chunyao Wang and Xiao Han and Wen Jiang and Guangqi Li and Jinchao Wang and Hua Guo and Huijun Chen},
abstract={Cervical Spondylotic Myelopathy (CSM) is a progressive central-nervous degenerative disease caused by vertebral volume abnormalities. A certain proportion of postoperative patients suffered the fluctuation of symptoms after spinal canal decompression. Spinal cord blood supply change was reported as one of the crucial pathophysiological process in CSM. MR DTI has been verified as a relative mature technique in assessing neuro-impairment. In this study, we investigate the relationship between spinal cord blood perfusion and microstructure deficit using MR DSC and DTI technique respectively and find a certain correlation between DSC and DTI metrics.}
}
@inproceedings{ISMRM2018_5519,
annote={ISMRM2018_5519},
pages={5519},
file={ISMRM2018_5519.pdf:ISMRM2018_5519.pdf:PDF},
title={High SpatiotemporalResolution {DCE} {MRA} and Perfusion in a Single 4{DA}cquisition Exploiting KineticModel Based Signal Priors},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5519.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Eun Ji Lim and Joon Sik Park and Eung Yeop Kim and Chul-Ho Sohn and Jaeseok Park},
abstract={In this work we develop a high spatiotemporal resolution (spatial ~ 1.0 mm3, temporal ~ 1.6 sec) simultaneous DCE MRA and perfusion within a single 4D acquisition exploiting kinetic model based signal priors. It is demonstrated that the proposed, high spatiotemporal resolution DCE MRI, which enables rapid sampling of AIF, depicts microvascular permeability in pathological tissues (e.g., tumor) much more accurately than conventional DCE MRI (temporal resolution: 5.0 sec).}
}
@inproceedings{ISMRM2018_5520,
annote={ISMRM2018_5520},
pages={5520},
file={ISMRM2018_5520.pdf:ISMRM2018_5520.pdf:PDF},
title={Whole Brain Absolute {CBF} Measurements Using Ultra-Low {GBCA} {DCE}-{MRI} and Microsphere Model},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5520.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ka-Loh Li and Daniel Lewis and Alan Jackson and Sha Zhao and Xiaoping Zhu},
abstract={Previous authors have attempted to utilize the microsphere model and a maximum gradient (MG) based approach to estimate cerebral blood flow from DCE MRI data, which, however, was not widely accepted. This study developed a new methodology based on the microsphere theory and “early time points” method for mapping absolute CBF, using ultra-low contrast agent dose T1W-DCE-MRI. The new method was assessed using both computer simulation and in vivo data analysis in a patient with GBM, demonstrating that the new method performed better than previous approaches, e.g. MG-based methods, while using much lower dose than perfusion methods based on DSC-MRI.}
}
@inproceedings{ISMRM2018_5521,
annote={ISMRM2018_5521},
pages={5521},
file={ISMRM2018_5521.pdf:ISMRM2018_5521.pdf:PDF},
title={Imaging ocular water inflow in the mouse with deuterium oxide {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5521.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Eric R. Muir and Shengwen Deng and Shiliang Huang},
abstract={Abnormal intraocular fluid flow or clearance is involved with a variety of eye diseases such as diabetic retinopathy, but there is a lack of non-destructive methods to assess the permeability directly of water in the eye. In this study we investigate the feasibility of different MRI sequences for direct imaging of deuterium oxide inflow in the mouse eye. Balanced steady state free precession provided high signal to noise ratio for imaging deuterium oxide in the intraocular fluid, providing dynamic imaging of intraocular water inflow.}
}
@inproceedings{ISMRM2018_5522,
annote={ISMRM2018_5522},
pages={5522},
file={ISMRM2018_5522.pdf:ISMRM2018_5522.pdf:PDF},
title={Can ve be larger than one? A modification for asymmetric vascular permeability in Toft’s model may reveal glymphatic dysfunction in tumor},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5522.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Pei-Lun Yu and Ming Cheng and Kun-I Chao and Cheng-He Li and Chi-Shiun Chiang and Kung-Chu Ho and Yi-Jui Liu and Ruey-Hwang Chou and Fu-Nien Wang},
abstract={The v
e is limited between 0 and 1 by definition. However, we observed large v
e when fitted the Toft’s model or its modified version to both Gd-DTPA and D
2O perfusion MRI. In this study, we modified the v
e to P
as*v
e to incorporate the asymmetry permeability into model. Therefore, the region with high P
as*v
e in D
2O perfusion imaging may be attributed to the blocked pathway of water draining, which could be correlated to glymphatic dysfunction in tumor.}
}
@inproceedings{ISMRM2018_5523,
annote={ISMRM2018_5523},
pages={5523},
file={ISMRM2018_5523.pdf:ISMRM2018_5523.pdf:PDF},
title={{ASL} meets Machine Learning: Classification of type-2 diabetes and normoglycemia using {ASL}-derived cerebral hemodynamic features.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5523.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Maria-Eleni Dounavi and Christopher Martin and Dinesh Selvarajah and Aneurin J. Kennerley and Solomon Tesfaye and Eleni Vasilaki and Iain D. Wilkinson},
abstract={QUASAR ASL is an arterial transit time insensitive perfusion imaging technique which can be used to unravel hemodynamic patterns. This study evaluates cerebral perfusion hemodynamics using QUASAR in patients with type-2 diabetes mellitus (T2DM) and normoglycemic controls. In addition to standard perfusion parameters, multiple metrics were extracted from five QUASAR-derived curves pre and post acetazolamide injection both globally and locally, from regions adjacent to major vascular territories. Following feature reduction, a binary classification task was performed (normoglycemia vs. T2DM). Necessary steps were undertaken to reassure that the observed results were not due to overfitting. The achieved classification accuracy was 95\%.}
}
@inproceedings{ISMRM2018_5524,
annote={ISMRM2018_5524},
pages={5524},
file={ISMRM2018_5524.pdf:ISMRM2018_5524.pdf:PDF},
title={Reproducibility and quality assessment of a 3D-{EPI} Pulsed Arterial Spin Labelling scheme at 7 T in a clinical cohort},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5524.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Richard J Dury and Yasser Falah and Penny A Gowland and Nikos Evangelou and Susan T Francis and Molly G Bright},
abstract={3D-EPI arterial spin labelling (ASL) at 7T has been shown to provide advantages over 2D-EPI, however its reproducibility has not been determined. Here we assess the data quality of 7T 3D-EPI pulsed ASL data in healthy volunteers (HV) and Multiple Sclerosis (MS) patients demonstrating significantly higher temporal SNR (tSNR) in MS patients. On comparing repeats from two scans, acquired ~3 weeks apart, we observe good reproducibility of CBF estimates with a coefficient of variation of 14.7\% in HVs and 12.1\% in MS patients. This ASL method can be used to evaluate perfusion longitudinally in clinical cohorts.}
}
@inproceedings{ISMRM2018_5525,
annote={ISMRM2018_5525},
pages={5525},
file={ISMRM2018_5525.pdf:ISMRM2018_5525.pdf:PDF},
title={Blood transit time heterogeneity ({TTH}) mapping in the human brain with multi-{TI} p{CASL}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5525.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Michael Germuska and Thomas Okell and Richard Wise},
abstract={A blood transit transit heterogeneity (TTH) mapping method is presented based on the regularised fitting of multi-TI pCASL data. The method applies a gamma variate dispersion model to account for upstream flow dispersion and tissue transit heterogeneity. The approach is shown to have sufficient sensitivity to distinguish a range of TTH times in gray matter and results are comparable with previous ROI based approaches. The mapping of TTH has the potential to be a sensitive marker for cerebrovascular dysfunction.}
}
@inproceedings{ISMRM2018_5526,
annote={ISMRM2018_5526},
pages={5526},
file={ISMRM2018_5526.pdf:ISMRM2018_5526.pdf:PDF},
title={Impact of calibration method on {CBF} quantification using multiple post-labeling-delay {PASL}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5526.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Joana Pinto and Pedro Vilela and Michael A Chappell and Patrícia Figueiredo},
abstract={Absolute CBF quantification using ASL requires the normalization of the magnetization difference images by the equilibrium magnetization of arterial blood, which is usually extrapolated from the equilibrium magnetization measured in tissue. Although different calibration methods have been previously compared, a number of subtle processing options made in their practical implementation are often assumed or overlooked, compromising the utility of absolute quantification. We systematically compared different calibration methods and associated options in multiple post-labeling-delay pulsed ASL and found that they can severely impact CBF quantification. Our results highlight the need for consistent calibration pipelines for CBF quantification using ASL.}
}
@inproceedings{ISMRM2018_5527,
annote={ISMRM2018_5527},
pages={5527},
file={ISMRM2018_5527.pdf:ISMRM2018_5527.pdf:PDF},
title={Increasing Arterial Spin Labeling Perfusion Image Resolution Using Convolutional Neural Networks with Residual-Learning},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5527.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Qingping Liu and Jun Shi and Ze Wang},
abstract={A common problem in arterial spin labeling (ASL) perfusion MRI is the relatively low spatial resolution and subsequently the partial volume effects. We evaluated a new deep learning-based super-resolution algorithm for solving that problem. The algorithm successively produced higher resolution ASL cerebral blood flow image from low resolution data, which even outperformed an existing super-resolution method.}
}
@inproceedings{ISMRM2018_5528,
annote={ISMRM2018_5528},
pages={5528},
file={ISMRM2018_5528.pdf:ISMRM2018_5528.pdf:PDF},
title={Feasibility Study of Arterial Spin Labeling on a Compact 3T Scanner with High-Performance Gradient System},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5528.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yunhong Shu and Shengzhen Tao and Marc Lebel and Ek Tan and MyungHo In and Joshua D Trzasko and Erin Gray and Thomas Foo and John Huston III and Matt A Bernstein},
abstract={Our study shows that pCASL based on a 3D segmented fast spin-echo spiral sequence can be performed on a compact 3T (C3T) scanner without the need of second RF transmitter. The high performance gradient system on the C3T can reach 80 mT/m magnitude and 700 T/m/s slew rate without peripheral nerve stimulation, which helps to shorten both the TE and spiral readout length. Both the perfusion-weighted images and the cerebral blood flow maps acquired on the C3T have higher spatial resolution and less off-resonant artifacts compares to those acquired on the conventional whole-body system enabled by the high performance gradients.}
}
@inproceedings{ISMRM2018_5529,
annote={ISMRM2018_5529},
pages={5529},
file={ISMRM2018_5529.pdf:ISMRM2018_5529.pdf:PDF},
title={{QUANTITATIVE} {MULTIPLE} {BOLI} {ARTERIAL} {SPIN} {LABELLING}: {FROM} {PULSED} {TO} {PSEUDO}-{CONTINUOUS} {LABELLING}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5529.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Antoine Vallatos and Camille Graff and Samantha Paterson and William M. Holmes},
abstract={A quantitative kinetic model for the recently introduced high SNR multiple boli Arterial Spin Labelling technique (mbASL) has been developed and validated both theoretically and experimentally. By varying the labelling inversion thickness, mbASL signal was shown to switch from a pseudo-continuous to a pulsed ASL behaviour. The model reflects the hybrid nature of mbASL, which combines the high labelling efficiency of pulsed ASL with the continuous labelling advantage of pseudo-continuous ASL. We use the mbASL kinetic model produce high SNR cerebral blood flow maps based on mbASL measurements.}
}
@inproceedings{ISMRM2018_5530,
annote={ISMRM2018_5530},
pages={5530},
file={ISMRM2018_5530.pdf:ISMRM2018_5530.pdf:PDF},
title={Accounting for p{CASL} labelling efficiency variation in patients with low and high arterial blood flow velocities},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5530.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Lena Vaclavu and Magdalena Sokolska and Aart J Nederveen and David L Thomas},
abstract={Pseudo continuous arterial spin labelling (pCASL) suffers from reduced labelling efficiency in extreme flow conditions. In this work we investigated the sensitivity of labelling efficiency to velocity values measured in vivo to ascertain its variability over a clinically relevant range of velocities. We measured arterial blood velocity in the neck at the level of the labelling plane and obtained simulated labelling efficiency values, which we found to differ significantly between high and low velocity populations. Changes in labelling efficiency induced by acetazolamide administration may have implications for future work using pCASL for cerebrovascular reserve assessments.}
}
@inproceedings{ISMRM2018_5531,
annote={ISMRM2018_5531},
pages={5531},
file={ISMRM2018_5531.pdf:ISMRM2018_5531.pdf:PDF},
title={Measurements of the Labeling Efficiency using super-selective Arterial Spin Labeling for Quantitative Flow Territory Mapping},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5531.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Thomas Lindner and Mariya Krestina and Olav Jansen and Michael Helle},
abstract={In this study, super-selective pseudo-continuous Arterial Spin Labeling was improved regarding the labeling efficiency and used in a volunteer study to evaluate the influence of the positioning of the focus with respect to the labeling efficiency.}
}
@inproceedings{ISMRM2018_5532,
annote={ISMRM2018_5532},
pages={5532},
file={ISMRM2018_5532.pdf:ISMRM2018_5532.pdf:PDF},
title={3D {MRI} of Blood Flow of Human Retina},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5532.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Xiang He and Kenneth T Wengler and Andrew LaBella and Tao Wang and Patricia Stefancin and Tim Q Duong},
abstract={Previous studies have shown that blood flow in the human retina can be measured using MRI. These studies used single-slice 2D pseudo-continuous arterial spin labeling (pCASL) which has limited spatial coverage and resolution and is susceptible to through-plane eye motion. In this study, a pCASL with zoom-3D TSE VFA acquisition was developed to provide whole-eye coverage with 0.5×0.5×4mm
3 resolution and reduced motion induced image blur. This approach should prove useful for studying different retinal disorders such as glaucoma, diabetic retinopathy and retinal ischemia.}
}
@inproceedings{ISMRM2018_5533,
annote={ISMRM2018_5533},
pages={5533},
file={ISMRM2018_5533.pdf:ISMRM2018_5533.pdf:PDF},
title={Efficient kidney perfusion imaging using non-segmented coronal slab 3D echo planar imaging with pseudo continuous arterial spin labeling},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5533.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Neville D Gai and Ashkan A Malayeri},
abstract={Arterial spin labeling (ASL) of the kidneys provides several advantages for the evaluation of kidney perfusion including contrast agent free studies while allowing multiple scans over a short time period. 3D acquisition provides higher SNR and with centric k-space encoding provides a well-defined post-labeling delay which makes background suppression pulses more effective. Prior techniques for 3D ASL perfusion imaging employed segmented GRASE with multi-TI FAIR and segmented TSE with pCASL. These acquisition schemes can be limited in resolution or require coached breathing along with providing limited coverage over an extended scanning time. In this work, we used non-segmented 3D EPI pCASL with coronal acquisition to efficiently image the two kidneys in a shorter time (nominal time 2:15) with increased control-label pairs. Background suppression and saturation pulses were also employed to reduce tissue related noise and signal from aorta, respectively. Cortical and medullary perfusion values were calculated in seven subjects which matched well with values from literature. In addition, good correspondence with transverse slab acquisition as well as good repeatability was shown.
}
}
@inproceedings{ISMRM2018_5534,
annote={ISMRM2018_5534},
pages={5534},
file={ISMRM2018_5534.pdf:ISMRM2018_5534.pdf:PDF},
title={How people recover from extreme life stress: a longitudinal dynamic functional connectivity analysis},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5534.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jing Jiang and Kaiming Li and Xiaoqi Huang and Su Lui and Zhiyun Jia and Qiang Yue and Qiyong Gong and Qiyu Liu},
abstract={Dynamic functional connectivity (dFC) has provided more information than commonly-used static FC analysis. With dFC, we investigated the variation characteristics of three affected resting state networks, i.e., DMN, CEN and SN, in trauma-exposed non-PTSD group using resting state fMRI scans within 25 days and 2 years after Wenchuan earthquake. Results revealed increased connectivity was mainly involved in intra-network FC of DMN and inter-network FC between SN and DMN/CEN. Decreased connectivity was mostly found in intra-network FC of CEN and inter-network FC between CEN and SN. This study may provide insights of how people recover from extreme life stress from a FC variation perspective.}
}
@inproceedings{ISMRM2018_5535,
annote={ISMRM2018_5535},
pages={5535},
file={ISMRM2018_5535.pdf:ISMRM2018_5535.pdf:PDF},
title={From neurons to {BOLD} connectivity: a validation study},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5535.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Andrea Duggento and Luca Passamonti and Gaetano Valenza and Riccardo Barbieri and Maria Guerrisi and Nicola Toschi},
abstract={The use of Multivariate Granger Causality (MVGC) in estimating directed BOLD connectivity is still controversial. We employ realistic complex network models based on Izhikevich neuronal populations interlinked by realistic neuronal fiber bundles which exert compounded directed influences and cascade into Baloon-model-like neurovascular coupling. We show in silico that the top 1 percentile of a BOLD connectivity matrix has a Positive Predictive Value very close to 1 and demonstrate in HCP data that functional interactions between parietal and prefrontal cortices are not symmetrical, but consists of directional connectivity from parietal areas to prefrontal cortices rather than vice versa.}
}
@inproceedings{ISMRM2018_5536,
annote={ISMRM2018_5536},
pages={5536},
file={ISMRM2018_5536.pdf:ISMRM2018_5536.pdf:PDF},
title={In-variance causality: a novel layer of information in directed connectivity},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5536.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Andrea Duggento and Luca Passamonti and Maria Guerrisi and Nicola Toschi},
abstract={Multivariate Granger Causality (MVGC) approaches have recently been employed to estimate the directionality of brain connectivity. While BOLD fluctuations also contain information about neurovascular coupling, so far all MVGC estimation frameworks have focused on central tendencies, hence disregarding directed coupling between volatilities (i.e. in-variance causality). In this paper, we develop a framework for simultaneous estimation of both in-mean and in-variance causality in complex networks. We validate our approach using synthetic data from complex ensembles of coupled nonlinear oscillators and successively employ HCP data to provide the very first estimate of the in-variance connectome of the human brain.}
}
@inproceedings{ISMRM2018_5537,
annote={ISMRM2018_5537},
pages={5537},
file={ISMRM2018_5537.pdf:ISMRM2018_5537.pdf:PDF},
title={Predicting Task Activation from Resting State f{MRI}: A Comparison of Single Band and Multiband {EPI} Acquisitions},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5537.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Alexander D. Cohen and Elizabeth Zakszewski and Yang Wang},
abstract={Recent studies have used resting state functional MRI (rs-fMRI) to predict task activation on an individual basis using a linear-regression machine learning technique. Limited existing studies have used either low-resolution single-band (SB) or high-resolution multiband (MB) data and shown promising results. In this study, SB and MB resting state data were acquired in a group of volunteers to compare their ability to predict motor task activation. Our results showed no significant differences between SB- and MB-based motor task predictions. These findings suggest conventional SB scans might be suitable for making predictions regarding task activation in some clinical settings.}
}
@inproceedings{ISMRM2018_5538,
annote={ISMRM2018_5538},
pages={5538},
file={ISMRM2018_5538.pdf:ISMRM2018_5538.pdf:PDF},
title={Individual Resting-State Brain Networks using Multivariate Conditional Mutual Information},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5538.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Padmavathi Sundaram and Martin Luessi and Marta Bianciardi and Steven Stufflebeam and Matti Hamalainen and Victor Solo},
abstract={Current methods of functional brain connectivity from resting-state fMRI data such as linear correlation have limitations, which result in connectivity maps affected by indirect connections and information loss. To address these problems, we propose to use a multivariate conditional mutual information (mvCMI) measure. mvCMI is a multivariate association method, which does not discard information and eliminates indirect connections. We tested mvCMI for single-subject fMRI-connectivity analysis in 10 healthy subjects. mvCMI was able to generate single-subject maps of functional connectivity showing mostly direct connections; mvCMI-based connectivity-maps were more closely related to diffusion-tensor-imaging-based structural connectivity-maps than linear-correlation-based connectivity-maps.}
}
@inproceedings{ISMRM2018_5539,
annote={ISMRM2018_5539},
pages={5539},
file={ISMRM2018_5539.pdf:ISMRM2018_5539.pdf:PDF},
title={Mapping the functional recovery of brainstem injury-induced comatose rats with eigenvector-centrality mapping and seed-based analysis of resting-state f{MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5539.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Patricia Pais Roldán and Brian Edlow and Johannes Stelzer and Yuanyuan Jiang and Ming Zou and Xin Yu},
abstract={Here we used the rat brainstem coma model and rs-fMRI to systematically study the network dynamics during recovery from coma. Using whole brain connectivity analysis we obtained connectivity slope maps from the comatose animals, which revealed the brain regions with higher connectivity changes. In parallel, we performed a seed-based analysis to specify the strengthened connections between ROIs. Both methods indicated an increase in the connectivity between basal forebrain, basal ganglia and thalamus, along the acute phase of recovery from coma. These parallel analyses applied to comatose rats provided new insights into the regulations occurring during recovery of consciousness.}
}
@inproceedings{ISMRM2018_5540,
annote={ISMRM2018_5540},
pages={5540},
file={ISMRM2018_5540.pdf:ISMRM2018_5540.pdf:PDF},
title={A correlation of resting state Df{MRI} signals reflects functional connectivity in awake mouse},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5540.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yoshifumi Abe and Yuki Sakai and Hiroaki Hamada and Norio Takata and Kenji Doya and Kenji Tanaka},
abstract={Diffusion fMRI (DfMRI) is an imaging method to investigate brain activity regardless of hemodynamic state. The previous study has proposed that resting state DfMRI (rsDfMRI) is suitable to investigate a magnitude of basal activity. In this study, we examined our hypothesis that this rsDfMRI have a potential of detecting functional connectivity (FC). FC patterns were compared between rsDfMRI and BOLD-rsfMRI in awake mice. A strong correlation of the pattern between rsDfMRI and BOLD-rsfMRI indicated that rsDfMRI is possible to conduct FC analysis. Therefore, we propose that rsDfMRI is a powerful tool to detect brain network as well as brain activity.}
}
@inproceedings{ISMRM2018_5541,
annote={ISMRM2018_5541},
pages={5541},
file={ISMRM2018_5541.pdf:ISMRM2018_5541.pdf:PDF},
title={A New Method of Brain Functional Connectivity Analysis via Deep Learning},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5541.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Brandon Campbell and Alice Shen and Simon Platt and Franklin West and Qun Zhao},
abstract={The pig brain model is an important translational model due to its similarity to the human brain anatomy and physiology. However, a lack of a priori information required for common functional analysis techniques dictates that new techniques are required to explore the connectivity of the pig brain. Here we present two new, unsupervised forms of analysis to find functional connectivity in healthy and ischemic stroke pigs using sparse deep convolutional neural networks and dynamic time warping with spectral clustering that yield complementary results.}
}
@inproceedings{ISMRM2018_5542,
annote={ISMRM2018_5542},
pages={5542},
file={ISMRM2018_5542.pdf:ISMRM2018_5542.pdf:PDF},
title={Functional Connectivity-Based Classification of Gulf War Illness Patients vs Control Veterans},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5542.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Unal "Zak" Sakoglu and Mounika Galla and Bruce Crosson and Robert Haley and Kaundinya Gopinath},
abstract={Around 200,000 veterans suffer from Gulf War Illness (GWI). GWI is characterized by multiple deficits in cognitive, emotion, somatosensory and pain domains. In this study we studied 23 GWI patients and 30 age-matched controls with resting state fMRI in order to classify patients versus controls using functional connectivity among brain networks. Results show that different brain networks have discriminating power, signaling widespread impairments in functional connectivity of visual, semantic, multi-sensory and sensory-motor processing networks in GWI consistent with multi-symptom nature of the illness.}
}
@inproceedings{ISMRM2018_5543,
annote={ISMRM2018_5543},
pages={5543},
file={ISMRM2018_5543.pdf:ISMRM2018_5543.pdf:PDF},
title={Dynamic network analysis reveals altered temporal variability in brain regions after brain stroke: A longitudinal resting-state f{MRI} study},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5543.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jianping Hu and Juan Du and Qiang Xu and Fang Yang and Fanyong Zeng and Zhiqiang Zhang and Guangming Lu},
abstract={In this work, we seek to investigate the longitudinal alteration of temporal variability inresting-state brain network after cerebral stroke, by using a novel dynamic network analysis. Our studyillustrated a time dependent alteration of temporal variability in brain networks following strokerecovery. These findings expand our understanding for dynamic properties of brain networks andprovide new insight into the underlying mechanisms of reorganization and integration of functionalnetworks over the recovery process after stroke.
}
}
@inproceedings{ISMRM2018_5544,
annote={ISMRM2018_5544},
pages={5544},
file={ISMRM2018_5544.pdf:ISMRM2018_5544.pdf:PDF},
title={Combining regional homogeneity and Meta-analysis to improve preoperative language mapping with resting-state functional {MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5544.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ai-Ling Hsu and Jason M Johnson and Kyle R Noll and Sujit S Prabhu and Donald F Schomer and Jyh-Horng Chen and Ho-Ling Liu},
abstract={Resting-state (rs) fMRI has been shown its potential for pre-surgical mapping. Seed-correlation analysis is a commonly used approach for network detection. However, lesion-related spatial distortions and functional reorganization make the seed selection difficult for rs-fMRI mapping based on anatomical landmark alone. Here we proposed a novel approach to guide the seed selection for rs-fMRI mapping in patients with brain tumors by incorporating regional homogeneity (RH) confined by results of meta-analysis (MA). Our results showed performance that was equivalent to the seed localization guided by task-fMRI activation, suggesting the potential of RH+MA approach for rs-fMRI mapping in the clinical practice.}
}
@inproceedings{ISMRM2018_5545,
annote={ISMRM2018_5545},
pages={5545},
file={ISMRM2018_5545.pdf:ISMRM2018_5545.pdf:PDF},
title={Altered Variability in Functional Connectivity of the Anterior Cingulate Cortex in Patients with Treatment-resistant and Non-treatment-resistant Depression},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5545.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Bochao Cheng and Gang Ning and Qiyong Gong},
abstract={Although substantial efforts have been made to elucidate the neuronal basis of both Treatment-resistant depression (TRD) and non-TRD (nTRD), the results are inconsistant. We apply the resting-state dynamic functional connectivity (D-RSFC) to explore the divergence of neuronal basis of both depression subtypes. Our results demonstrated that the prefrontal-limbic circuit is the most stable dysfunctional brain network in depression. The D-RSFC method could reveal the altered dynamic functional connectivity in both MDD subtypes and the divergence of brain networks between TRD and nTRD. Additionally, we speculate that the caudate-ACC circuit might be the biomarker for evaluating treatment response in TRD.}
}
@inproceedings{ISMRM2018_5546,
annote={ISMRM2018_5546},
pages={5546},
file={ISMRM2018_5546.pdf:ISMRM2018_5546.pdf:PDF},
title={Baseline dynamic functional connectivity predicts response to repetitive transcranial magnetic stimulation in patients with treatment-resistant depression},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5546.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Sarina Jennifer Iwabuchi and Dorothee P Auer and Sudheer Lankappa and Lena Palaniyappan},
abstract={Repetitive transcranial magnetic stimulation (rTMS) is becoming increasingly popular for the treatment of depression. However, there is a need for improving response through identifying predictive biomarkers and understanding mechanisms underlying treatment response to enable stratified patient care. We investigated in a group of 27 patients with treatment resistant depression, whether dynamic interactions between brain networks (measured with resting-state fMRI) can predict clinical response following 4 weeks of rTMS treatment. We found that clinical response may be more related to ‘trait’ like dynamic balance among large-scale networks that are present at the outset of treatment.}
}
@inproceedings{ISMRM2018_5547,
annote={ISMRM2018_5547},
pages={5547},
file={ISMRM2018_5547.pdf:ISMRM2018_5547.pdf:PDF},
title={Resting Functional Connectivity Across a Language Network Not Related to Task Based Language Laterality Index},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5547.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Akhila Ashokan and Victoria L Morgan},
abstract={Quantification of language dominance via a laterality index is used to assess the risk of language impairment prior to temporal lobe resection, most commonly in temporal lobe epilepsy. While task based functional MRI has become a useful non-invasive method for this measure, its reliability and accuracy can be reduced by poor task performance. In this work, resting fMRI connectivity in a language based network was investigated as an easier and more robust alternative to task based methods. However, results showed poor associations between the resting connectivity and the task based laterality.}
}
@inproceedings{ISMRM2018_5548,
annote={ISMRM2018_5548},
pages={5548},
file={ISMRM2018_5548.pdf:ISMRM2018_5548.pdf:PDF},
title={Regularized-Ncut: Robust functional parcellation of brain networks},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5548.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Qinmu Peng and Ouyang Minhui and Jiaojian Wang and Qinlin Yu and Chenying Zhao and Slinger Michelle and Hongming Li and Yong Fan and Bo Hong and Hao Huang},
abstract={Human brain functional networks are critical in understanding intrinsic functional organization and systems. However, functional brain parcellation is affected by noise, resulting in artificial small patches and decreased functional homogeneity within certain networks. Using resting-state fMRI, we proposed a novel data-driven regularized-Ncut (RNcut) method by integrating a smoothing term and a small patches removal term to conventional Ncut for parcellating functional networks. The proposed method could delineate parcellated functional networks with higher functional homogeneity and better spatial contiguity with less noisy patches. A broad range of brain network applications and analyses could benefit from the proposed RNcut.}
}
@inproceedings{ISMRM2018_5549,
annote={ISMRM2018_5549},
pages={5549},
file={ISMRM2018_5549.pdf:ISMRM2018_5549.pdf:PDF},
title={Altered structural covariance corticothalamic networks in epilepsy.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5549.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Qiang Xu and Qirui Zhang and Zhiqiang Zhang and Wei Quan and Junhao Xiao and Guangming Lu},
abstract={It is the first work to depict the corticothalamus relationship by using the structural covariance connectivity. The epilepsy would significantly change the cortex-thalamus mode. The unilateral foci would lead the damage to the ipsilateral thalamus firstly. It provided a novel window to detected the mechanism of epilepsy.}
}
@inproceedings{ISMRM2018_5550,
annote={ISMRM2018_5550},
pages={5550},
file={ISMRM2018_5550.pdf:ISMRM2018_5550.pdf:PDF},
title={Evaluation of fuzzy clustering for the identification of separate and joint dynamic functional connectivity patterns in resting-state f{MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5550.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Margarida Solas and Rodolfo Abreu and Cátia Salgado and Susana Vieira and Patrícia Figueiredo},
abstract={We propose to investigate the validity and applicability of fuzzy clustering (FCM) for the identification of dynamic functional connectivity (dFC) patterns in resting-state fMRI data and comparing it with two approaches that have been used in this context (PCA and K-means). For such purpose, all methods were applied to data simulating either the joint or separate expression of dFC patterns and to empirical data, collected from epilepsy patients. Both clustering methods, particularly FCM, outperformed PCA. Concomitantly, results from empirical data indicated that the occurrence of epileptic activity of patients was separately expressed by the dFC patterns.}
}
@inproceedings{ISMRM2018_5551,
annote={ISMRM2018_5551},
pages={5551},
file={ISMRM2018_5551.pdf:ISMRM2018_5551.pdf:PDF},
title={A methodology to study brain specialization and integration during the information processing},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5551.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Pedro Henrique Rodrigues da Silva and Renata Ferranti Leoni},
abstract={There is interest in understanding the functional integration of cognitive functions and effective therapeutic interventions as a strategy to improve cognitive deficits. However, uncertainty about how to proceed to address those issues remains. Therefore, this study aims to propose a methodology to assess brain specialization and integration during a cognitive task for future studies on the evaluation of therapeutic strategies. Our methodology provided a network model related to the performed task, that may serve as a reference for future investigations in clinical groups; and coupling parameters that may be used to evaluate the presence of adaptative neuroplasticity after cognitive training/rehabilitation.}
}
@inproceedings{ISMRM2018_5552,
annote={ISMRM2018_5552},
pages={5552},
file={ISMRM2018_5552.pdf:ISMRM2018_5552.pdf:PDF},
title={Clustering-based identification of Regions-of-Interest in Functional Magnetic Resonance Images},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5552.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Camila Rojas and Alejandro Weinstein and Steren Chabert and Alejandro Veloz},
abstract={The first step of brain network analysis in fMRI is to detect regions of interest. The signals from these ROIs are then used to evaluate neural networks and quantify neuronal dynamics The two main methods to identify ROIs are based on brain atlas registration and clustering. In this work, both paradigms are combined by using a hierarchical two-level approach. In the first level, the anatomical parcellation is applied and then a clustering-based strategy within anatomical labels is performed. The proposed method is compared with a current approach based on spectral clustering.}
}
@inproceedings{ISMRM2018_5553,
annote={ISMRM2018_5553},
pages={5553},
file={ISMRM2018_5553.pdf:ISMRM2018_5553.pdf:PDF},
title={Enhanced task-related frontoparietal functional connectivity during a n-back task in children with abacus training},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5553.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Chunjie Wang and Feiyan Chen and Huafeng Liu},
abstract={Abacus-based mental calculation (AMC) training has the potential to induce cognitive plasticity. However, the neural correlates of such benefits remain unknown. In this study, we aimed to examine impacts of AMC training on task-related functional connectivity. We obtained functional imaging data from 23 children with AMC training and 21 control children. For AMC children, we found a increase in task-related functional connectivity within the frontoparietal regions, which was also significantly correlated with the speed in the 2-back condition. Therefore, AMC training may enhance the functional integration of frontoparietal circuity and consequently result in improved task performance.}
}
@inproceedings{ISMRM2018_5554,
annote={ISMRM2018_5554},
pages={5554},
file={ISMRM2018_5554.pdf:ISMRM2018_5554.pdf:PDF},
title={{DEFAULT} {MODE} {NETWORK} {MODIFICATIONS} {IN} {FABRY} {DISEASE}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5554.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Sirio Cocozza and Giuseppe Pontillo and Mario Quarantelli and Francesco Saccà and Eleonora Riccio and Teresa Costabile and Gaia Olivo and Vincenzo Brescia Morra and Antonio Pisani and Enrico Tedeschi and Arturo Brunetti},
abstract={We performed a Resting-State fMRI study to evaluate the integrity of the Default Mode Network (DMN) in Fabry Disease (FD), a condition in which neuropsychological symptoms are common and alterations of the functional connectivity (FC) have been recently reported. Compared to healthy controls FD patients showed clusters of increased FC involving different DMN hubs as well as the middle temporal gyri and the right cerebellum, with a significant correlation with the Corsi span test results (P=0.0001). Our results confirm the current view of a cerebral involvement in FD patients related to significant and diffuse functional changes.}
}
@inproceedings{ISMRM2018_5555,
annote={ISMRM2018_5555},
pages={5555},
file={ISMRM2018_5555.pdf:ISMRM2018_5555.pdf:PDF},
title={Resting-State Functional Connectivity of the Language Network in Multiple Sclerosis in Young Adults},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5555.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Andrew LaBella and Lauren Krupp and Leigh Charvet and Lev Bangiyev and Tim Q Duong},
abstract={Multiple Sclerosis is affiliated with many clinical symptoms, including language deficiencies. However, the neural mechanism behind these problems hasn’t yet been explored. In this study, we use resting-state fMRI to probe the known language network in MS patients. We found that functional connectivity of the language network in MS patients is significantly correlated with clinical disability and results of a verbal learning test. Based on our results, we believe resting-state fMRI may be a viable tool to monitor language deficiencies in MS patients along with clinical scores.
}
}
@inproceedings{ISMRM2018_5556,
annote={ISMRM2018_5556},
pages={5556},
file={ISMRM2018_5556.pdf:ISMRM2018_5556.pdf:PDF},
title={Resting-State Fractional {ALFF} and Seed-Based Analysis as a Function of Bladder Discomfort},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5556.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Andrew LaBella and Kenneth Wengler and Justina Tam and Sindhuja T. Govindarajan and Steven Weissbart and Tim Q Duong and Xiang He},
abstract={The neural mechanisms underlying over active bladder are not fully understood. In addition, the neural network involved in bladder control hasn’t been identified. In this study, we looked at resting-state functional MRI of healthy females as a function of bladder filling, utilizing fractional amplitude of low frequency fluctuation (fALFF) and seed-based functional connectivity measures. Our results demonstrate modulated activation amplitude and functional connectivity throughout the brain, primarily characterized by increases in the anterior brain, furthering our understanding of bladder control and setting the foundation for additional higher level analyses.}
}
@inproceedings{ISMRM2018_5557,
annote={ISMRM2018_5557},
pages={5557},
file={ISMRM2018_5557.pdf:ISMRM2018_5557.pdf:PDF},
title={Resting-State Functional Connectivity of Subcortical Grey Matter Correlates with Fatigue in Young Adults with Multiple Sclerosis},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5557.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Andrew LaBella and Lauren Krupp and Leigh Charvet and Lev Bangiyev and Tim Q Duong},
abstract={While striatal and thalamic networks have been linked with fatigue in MS, they haven’t been explored in any young adult MS population. Further probing is needed to fully understand the fatigue correlate in MS and how it compares with differences between healthy controls and MS patients. In this study, we compared resting state functional connectivity measures in healthy controls, fatigued and non-fatigued MS patients. Our results demonstrate that fatigue correlates with deficits in subcortical connectivity with several resting state networks. We found overlap between certain MS-related and fatigue-related changes, providing further insight into MS pathology and its fatigue correlate.}
}
@inproceedings{ISMRM2018_5558,
annote={ISMRM2018_5558},
pages={5558},
file={ISMRM2018_5558.pdf:ISMRM2018_5558.pdf:PDF},
title={Application of f{MRI} with seed-based analysis for assessment of functional connectivity in patients with fragile X syndrome},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5558.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yulia Mikhailovna Rymareva and Evgeny Dmitrievich Petrovskiy and Andrey Alexandrovich Savelov and Evgenia Rovshanovna Isanova and Dmitry Vladimirovich Yudkin and Alexandr Pavlovich Chupakhin and Andrey Alexandrovich Tulupov},
abstract={The purpose of the study was to find neurobiological correlates of cognitive disability in patients with fragile X syndrome using resting state fMRI and seed-based correlation analysis.}
}
@inproceedings{ISMRM2018_5559,
annote={ISMRM2018_5559},
pages={5559},
file={ISMRM2018_5559.pdf:ISMRM2018_5559.pdf:PDF},
title={Disrupted resting-state functional connectivity and low-frequency fluctuation in chronic pain},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5559.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Woojin Choi and June Sic Kim and Chun Kee Chung},
abstract={By applying dynamic functional connectivity and low-frequency fluctuation analysis of resting-state fMRI data, the present study investigated a disrupted intrinsic resting-state network in chronic pain patients.}
}
@inproceedings{ISMRM2018_5560,
annote={ISMRM2018_5560},
pages={5560},
file={ISMRM2018_5560.pdf:ISMRM2018_5560.pdf:PDF},
title={Dynamic development of spontaneous neuronal activity in postpartum women: A longitudinal resting-state functional {MRI} study},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5560.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Kaihua Zhang and Mengxing Wang and Jilei Zhang and Haifeng Lu and Zhong Chen* and Xiaoxia Du*},
abstract={Investigating the neuroanatomical and functional bases in postpartum women have contributed to understanding the processing of cognitive and emotional alterations. The objective of this study was to examine spontaneous neuronal activity and functional connectivity of resting-state networks in postpartum women using a longitudinal resting-state functional magnetic resonance imaging. Twenty-three postpartum women were recruited. Amplitudeof low-frequency fluctuation (ALFF), regional homogeneity (ReHo) and functional connectivity werecalculated to measure spontaneous neuronal activity and brain network. Results revealed that changes in resting state brain network might be dynamic development for adaptive changes including cognitive function and empathic processing in postpartum women.}
}
@inproceedings{ISMRM2018_5561,
annote={ISMRM2018_5561},
pages={5561},
file={ISMRM2018_5561.pdf:ISMRM2018_5561.pdf:PDF},
title={Intra- and inter-scanner reliability of scaled subprofile model of principal component analysis in resting-state f{MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5561.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Li-Xia Yuan and Jian-Bao Wang and Na Zhao and Yuan-Yuan Li and Dong-Qiang Liu and Hong-Jian He and Jian-Hui Zhong and Yi-Long Ma and Yu-Feng Zang},
abstract={Scaled subprofile model of principal component analysis (SSM-PCA) is a multivariate statistical method, widely used in positron emission tomography (PET). Recently, SSM-PCA has been applied to resting-state functional MRI (RS-fMRI). However, the intra- and inter-scanner reliability of SSM-PCA in RS-fMRI is not investigated systematically yet. Results from eyes-open (EO) and eyes-closed (EC) dataset demonstrate that both the intra- and inter-scanner reliability is excellent for EO and EC related covariance pattern (EOEC-pattern) and fair to good for EOEC-pattern’s expression. Moreover, SSM-PCA and conventional T-test are complementary for neuroimaging researches. This study illustrates the great potential of SSM-PCA for further applications in RS-fMRI.}
}
@inproceedings{ISMRM2018_5562,
annote={ISMRM2018_5562},
pages={5562},
file={ISMRM2018_5562.pdf:ISMRM2018_5562.pdf:PDF},
title={Impact of Carotid Endarterectomy on Functional Connectivity},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5562.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Marc Lindley and Adam Bernstein and Chidi Ugonna and Denise Bruck and Kevin Johnson and Maria Altbach and Lee Ryan and Nan-kuei Chen and Ying-hui Chou and Gloria Guzman and Theodore Trouard and Craig Weinkauf},
abstract={Carotid endarterectomy (CEA) as a procedure has been shown effective in reducing the risk of stroke for patients with severe stenosis. The impact of CEA on the functional connectivity of the brain has not been assessed to this point. Nine patients underwent resting state fMRI pre-operatively and 1 month and 6 months post-operatively. Analysis was performed using seed based analysis and matrix based analysis to determine if there were functional connectivity changes as a result of CEA. Seed based and matrix based analysis showed that there were significant functional connectivity changes as result of CEA.}
}
@inproceedings{ISMRM2018_5563,
annote={ISMRM2018_5563},
pages={5563},
file={ISMRM2018_5563.pdf:ISMRM2018_5563.pdf:PDF},
title={Altered functional connectivity between cerebral and cerebellar resting-state networks in autism spectrum disorder},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5563.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yan Wang and Wenjing Zhang and Zheng Wang and Jieke Liu and John A. Sweeney and Stormi P. White and Su Lui and Matthew W. Mosconi},
abstract={By examining the correlation between motor data and brain resting-state functional imaging and identifying the functional connectivity alteration in ASD using a seed-driven approach, individuals with ASD demonstrate altered pattern of motor activation and diffusely decreased FC within frontal-subcortical-cerebellar circuit and within cerebellar network, which may represent the underlying neurobiological mechanisms of motor dysfunction and further delayed acquisition of gestures important for socialization and communication.}
}
@inproceedings{ISMRM2018_5564,
annote={ISMRM2018_5564},
pages={5564},
file={ISMRM2018_5564.pdf:ISMRM2018_5564.pdf:PDF},
title={The Effect of {HIV} and Aging on Functional Connectivity, Connectome Similarity and Structural changes},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5564.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yuchuan Zhuang and Lu Wang and Madalina Tivarus and Xing Qiu and Jianhui Zhong and Giovanni Schifitto},
abstract={We investigated the effect of HIV-infection and aging using resting-state fMRI and T1-weighted structural images. First, we assessed the inter-network functional connectivity and identified 8 resting-state networks associate with normal aging. Second, we constructed a functional connectome similarity as a global measure of neural connectivity pattern to assess the effect of age and HIV infection. Lastly, we measured cortical thickness and brain volumetrics. We found a significant effect of aging but not a definite additive or synergistic effect of HIV infection in all three analyses.}
}
@inproceedings{ISMRM2018_5565,
annote={ISMRM2018_5565},
pages={5565},
file={ISMRM2018_5565.pdf:ISMRM2018_5565.pdf:PDF},
title={Creativity Performance Reflected on the Activation of Divergent Thinking and Connectivity of Inferior Frontal Gyrus},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5565.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Hong-Yu Wu and Bo-Cheng Kuo and Chih-Mao Huang and Jyh-Horng Chen and Changwei W Wu},
abstract={Creativity is taken as a spontaneous mental process and creativity scales associates with resting-state functional connectivity in literature. However, it remains unclear that how brain integrity changes following creative thoughts. Targeting on this causal effect, we explored the functional connectivity before and after the engagement of divergent thinking. We demonstrated the interactions between brain activations in divergent thinking and functional connectivity in certain networks, especially in the locus of left inferior frontal gyrus (IFG). Meanwhile, the reduced IFG-precuneus connections could benefit the creativity performances.}
}
@inproceedings{ISMRM2018_5566,
annote={ISMRM2018_5566},
pages={5566},
file={ISMRM2018_5566.pdf:ISMRM2018_5566.pdf:PDF},
title={f{MRI}-measured brain responses to smoking-related images before and after smoking cessation treatment by varenicline},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5566.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Peng Peng and Li Chunlin and Jing Bin and Chu Shuilian and Jiang Tao},
abstract={This study investigated the activation of brain regions to visual smoking cues in smokers before and after cessation treatment using an event-related design fMRI. The result demonstrated that smokers will have good tolerance to smoking-related stimuli after using varenicline. This may explain why the curative effect of varenicline is better than NRT which has been related to an increased the brain response. The results provide further evidence for medication choice of clinicians for smoking cessation.}
}
@inproceedings{ISMRM2018_5567,
annote={ISMRM2018_5567},
pages={5567},
file={ISMRM2018_5567.pdf:ISMRM2018_5567.pdf:PDF},
title={Effects of smoking cessation treatment on cognition of smokers by using varenicline: a f{MRI} study},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5567.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Peng Peng and Li Chunlin and Jing Bin and Chu Shuilian and Jiang Tao},
abstract={This study investigated the working memory-related brain activity to 3 different difficulty level n-back task before and after cessation treatment. Brain activation increased with increasing task difficulty in both control and smoker groups. The brain activation of smokers was higher than that of the control group, but the activation degree of smoking cessation treatment group was significantly lower than that before treatment, which was close to that of the control group. The result demonstrated varenicline’s cure effect on improving cognitive function, which was important to improve the withdrawal symptoms and increase smoking cessation rate.}
}
@inproceedings{ISMRM2018_5568,
annote={ISMRM2018_5568},
pages={5568},
file={ISMRM2018_5568.pdf:ISMRM2018_5568.pdf:PDF},
title={The application of {ZOOM}it-{BOLD} for motor function localization in glioma},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5568.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Shengyu Fang and Tianyi Qian and Yinyan Wang and Tao Jiang},
abstract={ZOOMit blood oxygen level dependent fMRI (ZOOMit-BOLD) can excite only a small field of view using simultaneous parallel radiofrequency pulse sequences. It provides high spatial resolution while minimizing aliasing artifacts. This prospective study compared the clinical performances of ZOOMit-BOLD and conventional-BOLD in pre-surgical hand motor function localization. Compared with conventional EPI-based BOLD acquisition, ZOOMit-BOLD is a reliable technology with higher accuracy in preoperative motor functional localization in clinical patients with gliomas, particularly when the glioma directly invades the primary motor cortex.}
}
@inproceedings{ISMRM2018_5569,
annote={ISMRM2018_5569},
pages={5569},
file={ISMRM2018_5569.pdf:ISMRM2018_5569.pdf:PDF},
title={Novel {MRI}-compatible foot-sole stimulator for characterizing the cortical regions pertaining to walking-related somatosensory perception},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5569.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Tingwei Zhang and Kai Zhang and Yufeng Chai and Yunfei Long and Xiaoying Wang and Junhong Zhou and Brad Manor and Lewis A. Lipsitz and Jue Zhang and Jing Fang},
abstract={The decline of foot-sole somatosensation is one of the main contributors to diminished balance of walking. The response of brain regions to the inputs from foot-soles is critical to the somatosensory perception, which, however, remains unknown. Here we developed a dual-drive stimulator applying pressure stimuli that mimic those as experienced during walking on the feet. This stimulator is compatible for MRI and the foot-sole pressure stimuli significantly increases the excitability (i.e., BOLD signal intensity) within multiple brain regions. This stimulator may thus be a novel tool to characterize the brain’s responsiveness in the perception of foot-sole somatosensation pertaining to walking.}
}
@inproceedings{ISMRM2018_5570,
annote={ISMRM2018_5570},
pages={5570},
file={ISMRM2018_5570.pdf:ISMRM2018_5570.pdf:PDF},
title={Brain response to stop signal task in lifelong Premature Ejaculation patients compared to healthy subjects},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5570.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Lan Zhang and Xuejuan Yang and Ming Gao and Lin Liu and Peng Liu and Jinbo Sun and Wei Qin and Jie Tian},
abstract={Life-long premature ejaculation (LPE) is a common male sexual dysfunction. Previous studies revealed ejaculation-related control mechanisms in the brain. However, whether this control network changes in patients with LPE is unclear. A stop signal test was used in this study. A study of task-related functional MRI found there was a significant difference in neural network activation between healthy controls and LPE patients during go process. This study indicates a neural network abnormality in LPE patients, which provides novel reference for understanding the neural mechanism of LPE.}
}
@inproceedings{ISMRM2018_5571,
annote={ISMRM2018_5571},
pages={5571},
file={ISMRM2018_5571.pdf:ISMRM2018_5571.pdf:PDF},
title={T1-dispersion curves modelling and analysis of human glioma resections: a novel biomarker of molecular dynamics},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5571.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Manuel Petit and Sandra Pierre and Maxime Leclerq and Pascal H. Fries and François Berger and Lionel M. Broche and Hana Lahrech},
abstract={Here we aim to characterize human glioblastoma with FFC-NMR using cerebral tissue of normal pig as a reference. Power-law models and Fries-Belorisky model (quadrupolar
14N-
1H coupling peaks (QPs)) were used to analyse the T
1-dispersion. Linear Discriminant Analysis and statistical tests of derived fit parameters were used for classification. T
1 values at low field were found significantly different between cerebral tissues and glioblastoma, a result which is well admitted by the NMR community. However our most relevant finding is the role of the molecular dynamics related parameters to discriminate glioblastoma from cerebral tissues. QPs parameters also appear as a possible biomarkers but require higher signal sensitivity.}
}
@inproceedings{ISMRM2018_5572,
annote={ISMRM2018_5572},
pages={5572},
file={ISMRM2018_5572.pdf:ISMRM2018_5572.pdf:PDF},
title={{FFC}-{NMR}: A promise tool to discriminate infiltrative tumour cells from solid tumours: a study of three glioma mouse models},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5572.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Manuel Petit and Sandra Pierre and Maxime Leclerq and Pascal H. Fries and François Berger and Lionel M. Broche and Hana Lahrech},
abstract={Using Fast-Field Cycling NMR (FFC-NMR), three glioma mouse models were studied to compare T
1-dispersion curves of solid tumours (U87) versus infiltrative tumours (Glio6 and Glio96). The U87 T
1-dispersion curves were found distinct from those of Glio6 and Glio96 and fitted well to the power-law model (1/T
1=γ/2π B
0β). Statistical tests were used to find which model parameters discriminate the two tumour types. Results confirm the interest of low magnetic fields to exploit the offset parameter A, which corresponds to relaxation T
1, but specifically highlight the interest of the low-field exponent β
L parameter which give a molecular dynamic information, that is invisible by conventional NMR methods.}
}
@inproceedings{ISMRM2018_5573,
annote={ISMRM2018_5573},
pages={5573},
file={ISMRM2018_5573.pdf:ISMRM2018_5573.pdf:PDF},
title={Alterations of regional homogeneity in poststroke aphasia},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5573.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Hui Zhang and Ying Chen and Ruiping Hu and Liqing Yang and Mengxing Wang and Jilei Zhang and Yi Wu and Xiaoxia Du*},
abstract={The purpose of this study was to investigate intrinsic local synchrony changes in poststroke aphasia patients during resting-state fMRI scans. Fifteen patients (aged, 39-62 years, 4 female) and 30 age- and gender-matched healthy controls participated. Regional homogeneity (ReHo) was calculated to measure spontaneous brain activity. The results showed that poststroke aphasia patients exhibited significantly increased ReHo in the left frontal lobe, left cingulate gyrus, left corpus callosum, left temporo-parietal areas and right middle frontal gurus. Our study showed patterns of intrinsic local synchronization are altered in poststroke aphasia patients at resting state.}
}
@inproceedings{ISMRM2018_5574,
annote={ISMRM2018_5574},
pages={5574},
file={ISMRM2018_5574.pdf:ISMRM2018_5574.pdf:PDF},
title={Semantic verbal memory outcome in {TLE} and {ETLE} patients after surgery using f{MRI}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5574.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Kapil Chaudhary and Senthil Kumaran and P Sarat Chandra and Ashima Nehra and Manjari Tripathi},
abstract={Memory can be broadly classified as sensory (process > 1 second), short term (>1 minute) and long term encoding in which information is encoded, stored and retrieved. The surgical planning in drug refractory epilepsy (DRE) patients is usually associated with memory deficits. We measured BOLD activation during semantic verbal memory task using auditory stimulus and correlation with clinical parameters in patients (pre and 6 month of post-surgery) and controls. Study revealed anterior temporal lobe resection (ATLR) including removal of medial structures surrounding anterior temporal lobe may develop memory deficits in left TLE patients.}
}
@inproceedings{ISMRM2018_5575,
annote={ISMRM2018_5575},
pages={5575},
file={ISMRM2018_5575.pdf:ISMRM2018_5575.pdf:PDF},
title={Coupled temporal variation and global functional connectivity density of spontaneous brain activity in self-hypnosis for respiratory motion control},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5575.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yanjun Liu and Rongmao Li and Yaoqin Xie},
abstract={This study aims to explore the correlative relationship between temporal variation and signal synchronization of spontaneous brain activity in self-hypnosis for respiratory motion control and relaxation. A resting-state fMRI was employed to an intra-subject of 15 hypnotist volunteers in rest state and self-hypnosis state to explore the inter-state difference of correlation within four conventional resting-state networks. The results demonstrated that coupled temporal variation and signal synchronization of brain activity in self-hypnosis. It provides neural implications of self-hypnosis, a psychological technology that can generate positively psychological and physiological effects, in controllable self-regulation, which is beneficial to cancer patients during radiotherapy.}
}
@inproceedings{ISMRM2018_5576,
annote={ISMRM2018_5576},
pages={5576},
file={ISMRM2018_5576.pdf:ISMRM2018_5576.pdf:PDF},
title={Verifying the Reliability of Steady-State Free Precession f{MRI} in Detecting Oxygen Saturation Changes in Rat C6 Glioma},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5576.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Hao Chen and Junwei Zhang and Zhen Jiang and Jin Xu and Qiqi Chen and Siying Wang and Junkang Shen},
abstract={In this study, we aim to verify the reliability of steady-state free precession (SSFP) technique for detecting oxygen saturation level changes in functional MRI (fMRI). We compared SSFP fMRI image signals in rat glioma with pO
2 values measured directly using MRI compatible fiber-optic microprobes and we found that their temporal variations resembled each other. Therefore, SSFP fMRI, as a non-invasive imaging technique, can be used to reveal the location of re-oxygenation hence hypoxia in tumor.}
}
@inproceedings{ISMRM2018_5577,
annote={ISMRM2018_5577},
pages={5577},
file={ISMRM2018_5577.pdf:ISMRM2018_5577.pdf:PDF},
title={Intrinsic Frequency Specific Brain Networks of Parkinson's Disease Patients},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5577.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Xuemei Fu},
abstract={The majority of previous studies concerning the brain network derived from resting state fMRI focused on a low frequency of signal oscillation from 0.01 to 0.1 Hz (Bullmore and Sporns 2009; Van Den Heuvel and Hulshoff Pol 2010). However, the frequency specificities with regard to the topological properties of the PD brain networks have not been fully revealed. To exam the frequency properties of Drug-naive and L-dopa-treated Parkinson's Disease Patients, we subdivided the low frequency range into five bands as previously defined (Biswal et al., 1995; Buzsáki and Draguhn, 2004; Penttonen, 2003). The results suggest that the subdivided frequency bands prominently dissociate topological organisation of brain networks between drug-naive PD patients and L-dopa- treated PD patients.}
}
@inproceedings{ISMRM2018_5578,
annote={ISMRM2018_5578},
pages={5578},
file={ISMRM2018_5578.pdf:ISMRM2018_5578.pdf:PDF},
title={{BOLD} activation pattern of cerebrum for unilateral and bilateral wrist extension task among stroke patients and healthy subjects},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5578.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Neha Singh and Dixit Sharma and Megha Saini and Sneh Anand and Nand Kumar and MV Padma Srivastava and S Senthil Kumaran and Amit Mehndiratta},
abstract={Role of wrist-extension in motor control in upper-limb post-stroke recovery is significant. We compared neural structures controlling unilateral versus bilateral movement of wrist-extension task using fMRI in 6 healthy-volunteers and 6 stroke-patients. Significant BOLD activation was observed in PG during all three tasks in healthy-volunteers. Activation with bilateral-task were considerably higher than unilateral-task. In patients with stroke as a result of re-organization, ipsi-lesion cerebellum-area shows activation for affected-hand movement not present in healthy-volunteers, supporting evidence for advantages of bilateral-training in functional imaging. Knowledge of reorganization-pattern for coordinated-movement involved in bilateral-tasks may be helpful in addressing the rehabilitation of stroke-patients.}
}
@inproceedings{ISMRM2018_5579,
annote={ISMRM2018_5579},
pages={5579},
file={ISMRM2018_5579.pdf:ISMRM2018_5579.pdf:PDF},
title={Awake rat functional magnetic resonance imaging using 3D printed restrainment kit and standard {RF}-coils},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5579.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Petteri Stenroos and Jaakko Paasonen and Raimo Salo and Kimmo Jokivarsi and Olli Gröhn},
abstract={Anesthetics are typically used in preclinical functional magnetic resonance imaging (fMRI) experiments to prevent animal movement and stress, but anesthetics can significantly affect the brain function. Therefore, several awake fMRI protocols have been developed, usually implementing house-made coils and holders. In present study, we developed a 3D printable restrainment kit that is compatible with standard Bruker rat coils and holders. Subsequently, resting state functional connectivity (RSFC) data was obtained under awake, lightly sedated and anesthetized conditions. Our results show that even subanesthetic dose of isoflurane modulates FC significantly.
}
}
@inproceedings{ISMRM2018_5580,
annote={ISMRM2018_5580},
pages={5580},
file={ISMRM2018_5580.pdf:ISMRM2018_5580.pdf:PDF},
title={Accurate High Dynamic Range Displacement Measurement in {MR} Elastography Using a Simultaneous Dual-Sensitivity Acquisition},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5580.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yi Sui and Ziying Yin and Joshua D. Trzasko and Armando Manduca and Kevin J. Glaser and Richard L. Ehman and John Huston III},
abstract={Phase wrapping in MR Elastography (MRE) limits the dynamic range of the displacement information that can be reliably measured. We developed a novel framework that simultaneously acquires data with 2 levels of motion sensitivity and processes this data in a manner which increases the dynamic range of the accurately measured displacements by 8-10 times. Both shear wave and large bulk (rigid-body) motion in braincan be characterized in a single scan.}
}
@inproceedings{ISMRM2018_5581,
annote={ISMRM2018_5581},
pages={5581},
file={ISMRM2018_5581.pdf:ISMRM2018_5581.pdf:PDF},
title={{TURBINE}-{MRE}: A 3D Hybrid Radial-Cartesian {EPI} Acquisition for {MR} Elastography},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5581.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yi Sui and Arvin Arani and Joshua D. Trzasko and Shivaram P. Arunachalam and Kevin J. Glaser and Kiaran P. McGee and Phillip J. Rossman and Armando Manduca and Richard L. Ehman and John Huston III and Philip A. Araoz},
abstract={A 3D gradient-echo EPI MR Elastography pulse sequence has been developed using a hybrid radial-Cartesian readout scheme, named Trajectory Using Radially Batched Internal Navigator Echoes (TURBINE). The feasibility of this TURBINE-MRE sequence was demonstrated in a phantom study.}
}
@inproceedings{ISMRM2018_5582,
annote={ISMRM2018_5582},
pages={5582},
file={ISMRM2018_5582.pdf:ISMRM2018_5582.pdf:PDF},
title={Interventional {MR} Elastography and thermometry using simultaneous image refocusing ({SIR}) for multislice monitoring of thermal therapies},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5582.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Kisoo Kim and Elodie Breton and Afshin Gangi and Jonathan Vappou},
abstract={Interventional MR Elastography (MRE) and thermometry (PRF) using the Simultaneous Image Refocusing (SIR) technique is proposed in order to monitor changes in temperature and biomechanical properties during thermal ablations, in multiple contiguous slices. Compared to the conventional GRE-MRE sequence, two slices are acquired in each TR, with a single motion sensitizing gradient and similar fractional motion encoding. Elasticity maps obtained with SIR-GRE MRE are validated against reference single slice GRE-MRE. Preliminary experiments show the potential of contiguous multislice acquisition to monitor the volumetric extent of the heated area obtained with High Intensity Focused Ultrasound (HIFU) in a phantom.}
}
@inproceedings{ISMRM2018_5583,
annote={ISMRM2018_5583},
pages={5583},
file={ISMRM2018_5583.pdf:ISMRM2018_5583.pdf:PDF},
title={Finite Volume-Based Elasticity Recovery for Magnetic Resonance Elastography: Theory and Initial Results},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5583.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Joaquin Mura and Jürgen Braun and Ingolf Sack and Eric Barnhill},
abstract={We have developed a finite-volume based elasticity recovery method for Magnetic Resonance Elastography. The method accommodates heterogeneity and compressibility, uses only first derivatives, avoids matrix inversion and can be calculated in a highly efficient stencil format. We compared the method to a Helmholtz-type wave inversion. Visually, the method shows sharper rendering of cracks and boundaries. Quantitatively the values of the new method differ from a Helmholtz-type method in proportion to the severity of interfaces, which likely reflects the new method's sharper rendering. The resolution and sensitivity of the method lower the inherent stability, which we address here with a simultaneous multifrequency wave inversion. Future work will introduce sparsity-promoting regularization to deliver both stability and structure.}
}
@inproceedings{ISMRM2018_5584,
annote={ISMRM2018_5584},
pages={5584},
file={ISMRM2018_5584.pdf:ISMRM2018_5584.pdf:PDF},
title={Ristretto {MRE}: A Generalized Multi-Shot {GRE}-{MRE} Sequence},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5584.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Christian Guenthner and Sweta Sethi and Ayse Sila Dokumaci and Ralph Sinkus and Sebastian Kozerke},
abstract={The purpose of this work is to increase GRE-MRE sequence flexibility by generalizing the multi-shot eXpresso approach. We show that Ristretto MRE allows for the fine-tuning of imaging shot durations in both multi-slice and 3D-MRE acquisitions permitting significant scan time reductions without loss of image quality.}
}
@inproceedings{ISMRM2018_5585,
annote={ISMRM2018_5585},
pages={5585},
file={ISMRM2018_5585.pdf:ISMRM2018_5585.pdf:PDF},
title={In Vivo Cardiac {MR} Elastography using a Gravitational Transducer},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5585.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ayse Sila Dokumaci and Torben Schneider and Myrianthi Hadjicharalambous and Stefan-Heinz Hoelzl and Jelizaveta Sudakova and Daniel Hollands and Ralph Sinkus and David Alexander Nordsletten},
abstract={MR Elastography is valuable in evaluating biomechanical stiffness of tissues, which can exhibit marked changes in case of disease. However, the number of cardiac MRE studies remains limited due to challenges in measuring the dynamic muscle tissue using existing MRE sequences and hardware. Here, we aimed to acquire reliable cardiac MRE data by combining a gravitational transducer driven by a novel synchronising strategy with a single-shot SE-EPI-MRE sequence with flow and acceleration compensated motion encoding gradients to image the myocardium in different cardiac phases. Our method reveals higher myocardial stiffness, agreeing with results from biomechanical models/simulations, conflicting with current literature.}
}
@inproceedings{ISMRM2018_5586,
annote={ISMRM2018_5586},
pages={5586},
file={ISMRM2018_5586.pdf:ISMRM2018_5586.pdf:PDF},
title={Accelerating {MR} Elastography acquisition with compressed sensing},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5586.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Hui Wang and Jean Tkach and Andrew Trout and Charles Dumoulin and Jonathan R. Dillman},
abstract={We propose the use of compressed sensing (CS) for Magnetic Resonance Elastography (MRE). Through validation in a gel phantom and subsequent measurement of liver stiffness in vivo, we demonstrate that CS MRE can be used to accelerate image acquisition, thereby shortening breath holds.}
}
@inproceedings{ISMRM2018_5587,
annote={ISMRM2018_5587},
pages={5587},
file={ISMRM2018_5587.pdf:ISMRM2018_5587.pdf:PDF},
title={Inversion-recovery based {MR} poro-elastography for biphasic analysis of tofu phantoms and in vivo human brains},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5587.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ledia Lilaj and Jürgen Braun and Thom Fischer and Ingolf Sack and Sebastian Hirsch},
abstract={A novel magnetic resonance elastography (MRE) sequence, combining inversion recovery (IR) with MRE, is introduced to quantify poroelastic properties of biphasic materials. The method is demonstrated on custom-made tofu phantoms featuring biphasic tissue properties with different porosities and elastic moduli. IR-MRE allows for the first time to study the individual fluid and matrix motion in a biphasic medium and the interactions between the two. The same technique applied to in vivo brain also confirms fundamental predictions of poroelasticity theory and demonstrates the transferability of IR-MRE from simple biphasic model materials to complex living tissues.}
}
@inproceedings{ISMRM2018_5588,
annote={ISMRM2018_5588},
pages={5588},
file={ISMRM2018_5588.pdf:ISMRM2018_5588.pdf:PDF},
title={Mechanical characterization of rat liver tissue in native, lysed and decellularized states by 0.5 T tabletop magnetic resonance elastography ({MRE})},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5588.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Angela Ariza de Schellenberger and Hannah Everwien and Nils Haep and Igor Sauer and Heiko Tzschätzsch and Judith Bergs and Jürgen Braun and Ingolf Sack},
abstract={Establishing the ideal 3D-matrix for organ regeneration is one of the big challenges in regenerative medicine. The mechanical properties of the extracellular matrix (ECM) are incompletely understood, partly due to the limited availability of volume-based mechanical test methods such as MRE. Therefore, we used a 0.5 T compact tabletop MRE system and measured the change of stiffness in rat livers due to decellularization and cell wall disruption by lysis. While the viscoelastic properties of intact liver tissue are determined by cells and can be described by a power law behavior, decellularized tissue has more solid-like properties following a Kelvin-Voigt-model behavior.}
}
@inproceedings{ISMRM2018_5589,
annote={ISMRM2018_5589},
pages={5589},
file={ISMRM2018_5589.pdf:ISMRM2018_5589.pdf:PDF},
title={Experimental validation of appropriate conditions for accurate and precise Magnetic Resonance Elastography: an in vitro phantom study},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5589.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jinlong Yue and Felicia Julea and Tanguy Boucneau and Claire Pellot-Barakat and Xavier Maître},
abstract={Magnetic Resonance Elastography (MRE) allows to non-invasively characterize the mechanical properties in vivo. The reconstruction performance is challenged by multiple experimental parameters, which can be grouped into two more comprehensive parameters: number of voxels per wavelength and acquired displacement field quality. In a previous in silico study, we have demonstrated that appropriate λ/a condition is crucial for accurate and precise MRE and proposed a quality parameter to effectively evaluate the voxel-wise reconstruction quality. This study experimentally validated these simulation findings on commercial model phantoms.}
}
@inproceedings{ISMRM2018_5590,
annote={ISMRM2018_5590},
pages={5590},
file={ISMRM2018_5590.pdf:ISMRM2018_5590.pdf:PDF},
title={Clinical Validation of a Semiautomated Workflow for {MR} Elastography},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5590.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Bogdan Dzyubak and Sudhakar K Venkatesh and Glaser J Kevin and Richard L. Ehman},
abstract={Magnetic Resonance Elastography (MRE) is a validated method for staging hepatic fibrosis utilizing MR images of acoustic wave propagation in the liver to measure hepatic stiffness. A new MRE analysis workflow, called ALEC, in which readers are presented with preliminary, automatically generated, ROIs was validated in a clinical environment using 1347 exams. The workflow failed in <1\% of cases. Manual modification was performed on 18\% of the exams, leading to a stiffness change of only 1\% on average. The ALEC-assisted stiffness measurement workflow offers a faster and more reproducible way to perform MRE.}
}
@inproceedings{ISMRM2018_5591,
annote={ISMRM2018_5591},
pages={5591},
file={ISMRM2018_5591.pdf:ISMRM2018_5591.pdf:PDF},
title={Magnetic resonance elastography accuracy and precision in rat lung and liver at 1.5 T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5591.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Felicia Julea and Hongchen Wang and Jin Long Yue and Tanguy Boucneau and Claire Pellot-Barakat and Xavier Maître},
abstract={Magnetic Resonance Elastography (MRE) is a non-invasive MRI based technique for quantitatively assessing the mechanical properties of tissues. It was formerly demonstrated in a simulation study that 6 to 9 voxels per wavelength is needed to properly quantify the mechanical properties of the tissue. This study investigates the precision and the accuracy of shear wave velocity in two organs at different mechanical excitation frequency and spatial resolution to validate in vivo the optimal conditions of ERM outcomes.}
}
@inproceedings{ISMRM2018_5592,
annote={ISMRM2018_5592},
pages={5592},
file={ISMRM2018_5592.pdf:ISMRM2018_5592.pdf:PDF},
title={Magnetic Resonance Elastography ({MRE}) Reveals Muscle Instability in Middle Aged Healthy Adults},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5592.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Michael Perrins and Michiel Simons and Paul Kennedy and Lisa Salisbury and Colin Brown and Timothy Walsh and Edwin J.R. van Beek and David Griffith and Neil Roberts},
abstract={Age-related weakness and strength has been shown to have an anatomical basis, with stability of the knee being particularly prone to effects of ageing. Magnetic Resonance Elastography (MRE) was used to obtain muscle size and stiffness measurements in a ‘Younger’ and ‘Older’ group of participants. It was found that the Quadriceps muscle group were primarily impacted by age related atrophy, whilst also increasing in stiffness with age. Furthermore, the muscles along the medial side of the leg showed significantly lower muscle stiffness in ‘Older’ participants which we determined to be a biomarker for age-related anatomical instability.}
}
@inproceedings{ISMRM2018_5593,
annote={ISMRM2018_5593},
pages={5593},
file={ISMRM2018_5593.pdf:ISMRM2018_5593.pdf:PDF},
title={Poroelastic and Viscoelastic {MRE} of Experimental Phantoms Actuated at 1Hz},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5593.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Matthew McGarry and Ligin Solamen and Scott Gordon-Wylie and John Weaver and Keith Paulsen},
abstract={Poroelastic and viscoelastic inversions in a 1Hz experimental MR Elastography phantom system were investigated theoretically, numerically and experimentally. At low frequencies, viscoelastic models have a non-uniqueness issue that can be avoided by using a poroelastic model, which has an additional fluid force term to balance elastic forces when inertial forces are negligible. Numerical experiments showed poroelastic models have much higher sensitivity to global property changes compared to viscoelastic models. Inversions of experimental phantom data with a poroelastic model gave cleaner images that are less sensitive to initial property estimates compared to a viscoelastic model.}
}
@inproceedings{ISMRM2018_5594,
annote={ISMRM2018_5594},
pages={5594},
file={ISMRM2018_5594.pdf:ISMRM2018_5594.pdf:PDF},
title={Dynamic Magnetic Resonance Elastography ({DMRE}): A Novel Imaging Technique to Identify Active Muscle Recruitment},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5594.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Michiel Robert Simons and Michael Perrins and Andre Attard and Colin Brown and Neil Roberts and Edwin J.R. van Beek and Leela Biant},
abstract={Dynamic Magnetic Resonance Elastography (DMRE) is a novel imaging technique which allows the quantification of muscle characteristics during a loaded MRE scan. Thigh muscle loading results in increased muscle stiffness. DMRE offers clinicians new insights into muscle engagement which aids in diagnosis and treatment for musculoskeletal pathologies. This work has shown DMRE is a sensitive tool to detect active muscle engagement.}
}
@inproceedings{ISMRM2018_5595,
annote={ISMRM2018_5595},
pages={5595},
file={ISMRM2018_5595.pdf:ISMRM2018_5595.pdf:PDF},
title={Thigh Muscle Recruitment Following Total Knee Replacement Surgery Using Dynamic Magnetic Resonance Elastography ({DMRE})},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5595.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Michiel Robert Simons and Michael Perrins and Gwenllian Tawy and Colin Brown and Neil Roberts and Edwin J.R. van Beek and Leela Biant},
abstract={In this study, Dynamic Magnetic Elastography (DMRE) is applied to a clinical cohort. DMRE scans were carried out in patients with severe OA pre and post-op Total Knee Replacement. Muscle recruitment was identified through increased muscle stiffness. Post operatively, muscle stiffness changes observed during dynamic loading were markedly less compared with their pre-op scan. This study supports the use of personalised targeted physiotherapy in muscle rehabilitation.}
}
@inproceedings{ISMRM2018_5596,
annote={ISMRM2018_5596},
pages={5596},
file={ISMRM2018_5596.pdf:ISMRM2018_5596.pdf:PDF},
title={Physiomechanical noise in brain magnetic resonance elastography},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5596.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Charlotte A Chaze and Curtis L Johnson},
abstract={Magnetic resonance elastography (MRE) is an emerging MRI technology that enables in-vivo quantitative assessment of tissue stiffness, which changes with age and in disease states. The accuracy and precision of brain MRE property maps are generally noise-limited; however, most noise assessments don’t appropriately consider contributions from physiological and mechanical noise sources, such as cardiac pulsation, table shaking and imperfect actuation. In this work, we designed and carried out experiments to isolate these sources of noise. We found increasing noise from physiological vibration sources with varying behavior through space and time.}
}
@inproceedings{ISMRM2018_5597,
annote={ISMRM2018_5597},
pages={5597},
file={ISMRM2018_5597.pdf:ISMRM2018_5597.pdf:PDF},
title={Wave propagation in multi-excitation magnetic resonance elastography of the brain},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5597.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Daniel R Smith and Philip V Bayly and Anthony J Romano and Curtis L Johnson},
abstract={MR elastography (MRE) is capable of measuring the mechanical properties of the human brain; however, MRE generally assumes isotropic properties and misses the anisotropic behavior of brain white matter. Anisotropic MRE methods are under development and the use of multiple wave propagation directions is likely necessary for accurate inversion. In this work, we characterize waves in brain MRE from multiple excitations and evaluate whether sufficient wave propagation is present. We find that multi-excitation MRE motion fields in the brain exhibit wave content in white matter tracts sufficient for anisotropic inversion.}
}
@inproceedings{ISMRM2018_5598,
annote={ISMRM2018_5598},
pages={5598},
file={ISMRM2018_5598.pdf:ISMRM2018_5598.pdf:PDF},
title={3D Magnetic Resonance Elastography of the Lungs in A Breathhold: A Reproducibility Study.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5598.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Faisal Fakhouri and Huiming Dong and Arunark Kolipaka},
abstract={Lung stiffness changes with different diseases; in which some diseases make the lung stiffer while others make it softer. This study was performed on 15 healthy volunteers to validate the reproducibility of proposed technique and to determine a base line shear stiffness of healthy lungs at both residual volume (RV) and total lung capacity (TLC) by using magnetic resonance elasotgraphy (MRE). It was found that the actual shear stiffness of the lung at RV is 0.66±0.11 kPa and at TLC is 1.05±0.31 kPa. Also, the technique was successfully reproducible with high correlation coefficients (R
2=0.879 at RV and R
2=0.961 at TLC).}
}
@inproceedings{ISMRM2018_5599,
annote={ISMRM2018_5599},
pages={5599},
file={ISMRM2018_5599.pdf:ISMRM2018_5599.pdf:PDF},
title={Helmholtz Inversion Using Unconstrained Optimization for {MR} Elastography},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5599.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Huiming Dong and Rizwan Ahmad and Arunark Kolipaka},
abstract={MR elastography (MRE) is a phase-contrast MR technique in which the shear stiffness of soft tissues can be estimated. Helmholtz equation-based inversion is used to obtain stiffness of interest from MRE measurements. It is challenging to accurately estimate stiffness due to the presence of noise. In this work, an inversion method based on unconstrained optimization has been proposed where noise is reduced from the measured data while the sparsity of stiffness map in wavelet domain is being explored. Results demonstrated that optimization yielded more accurate stiffness estimation with lower root-mean-square error and lower maximum error when compared to local-frequency estimation.}
}
@inproceedings{ISMRM2018_5600,
annote={ISMRM2018_5600},
pages={5600},
file={ISMRM2018_5600.pdf:ISMRM2018_5600.pdf:PDF},
title={Power-Law Multi-Frequency {MR} Elastography of the Human Brain with Super-resolution Imaging via Non-Linear Inversion},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5600.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Elijah E.W. Van Houten and Julien Testu and Florian Dittmann and Matthew D.J. McGarry and John B. Weaver and Keith D. Paulsen and Ingolf Sack},
abstract={This abstract presents a non-linear inversion based power-law multi-frequency MR Elastography reconstruction, capable of reconstructing images at resolutions finer than the acquired displacement data. Reconstructed power-law parameters are compared with those obtained by logarithmic regression based on mono-frequency reconstructions of the same data.}
}
@inproceedings{ISMRM2018_5601,
annote={ISMRM2018_5601},
pages={5601},
file={ISMRM2018_5601.pdf:ISMRM2018_5601.pdf:PDF},
title={Comparison of Magnetic Resonance Elastography ({MRE}) Inversion Reproducibility using {MDEV} and {MRE}dge in the Brain for the Same Subjects at 1.5, 3 and 7 Tesla},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5601.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Helen Marshall and Lucy Hiscox and Michael Perrins and Ingolf Sack and Jürgen Braun and Tom Meyer and Tim Herrmann and Johannes Bernarding and Edwin J R van-Beek and Neil Roberts and Eric Barnhill},
abstract={Magnetic Resonance Elastography (MRE) provides quantitative measures of the mechanical properties of biological tissues. As MRE becomes more widely used, it is important to assess different methods of data acquisition and analysis. In this study, a comparison was made between 3 field strengths using Multi-frequency duel Elasto Visco inversion (MDEV) and the new MREdge pipeline. Both inversions demonstrated significant differences in stiffness at each field strength, MDEV also displayed excellent correlation at 1.5, 3 and 7T. MDEV remains the preferred method of inversion with MREdge offering the prospect of an automatic pipeline which provides stiffness estimates for specific brain regions.}
}
@inproceedings{ISMRM2018_5602,
annote={ISMRM2018_5602},
pages={5602},
file={ISMRM2018_5602.pdf:ISMRM2018_5602.pdf:PDF},
title={Real-time {ECG}-gated continuous vibration multi-shot spiral elastography acquisition: application to time-resolved cerebral stiffness measurements during arterial pulsation.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5602.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Carsten Warmuth and Felix Schrank and Thomas Elgeti and Jürgen Braun and Ingolf Sack},
abstract={We implemented a versatile spiral MRE sequence that synchronizes the acquisition in real-time to a continuous harmonic vibration. Using multi-shot gradient echo readout and fractional motion encoding, multiple phases can be acquired in the cardiac cycle with high temporal resolution. Optionally, prospective respiratory gating and slice tracking allow for imaging moving organs like the heart or the liver in free breathing. As a first application, we measured cerebral stiffness maps in multiple phases of the cardiac cycle to detect changes induced by arterial pulsation.}
}
@inproceedings{ISMRM2018_5603,
annote={ISMRM2018_5603},
pages={5603},
file={ISMRM2018_5603.pdf:ISMRM2018_5603.pdf:PDF},
title={Magnetic Resonance Elastography Measures Predict White Matter Microstructure and Aging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5603.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Boris Gutman and Aaron T Anderson and Nicolas Gallo and John G Georgiadis},
abstract={We assessed the relationship between microstructural measures derived from diffusion tensor imaging (DTI) and shear moduli estimated from magnetic resonance elastography (MRE). We also compared the predictive power of fractional anisotropy, storage and loss moduli, estimation using nonlinear inversion (NLI) to model age in humans. Our results suggest some statistical relationship between MRE measures, particularly the loss modulus and microstructure (FA, RD). The decrease in FA with age is accompanied by an increase in viscosity, especially in association fibers (Superior Longitudinal Fasciculus). The regional MRE measure provides more predictive power than the best regional FA.
}
}
@inproceedings{ISMRM2018_5604,
annote={ISMRM2018_5604},
pages={5604},
file={ISMRM2018_5604.pdf:ISMRM2018_5604.pdf:PDF},
title={Improve {PCASL} Brain Imaging at 7T Using Dynamically Applied B1+ Shimming Solutions},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5604.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Xiufeng Li and Dingxin Wang and Xiaoping Wu and Pierre-Francois Van de Moortele and Kamil Ugurbil and Gregory J. Metzger},
abstract={The rapid decline of transmit B
1 ( B
1+) toward the inferior brain regions and large B
1+ inhomogeneity across blood feeding arteries at the labeling plane impose great challenges for high quality pseudo-continuous arterial spin labeling (PCASL) brain imaging at 7T. Recent studies at 7T have suggested that dynamically applied B
1+ shimming solutions separately targeted to imaging and labeling regions can help to overcome these challenges. We implemented and evaluated the dynamic B
1+ shimming approach for PCASL brain imaging at 7T, demonstrating that such an approach can greatly improve B
1+ performance for blood tagging.}
}
@inproceedings{ISMRM2018_5605,
annote={ISMRM2018_5605},
pages={5605},
file={ISMRM2018_5605.pdf:ISMRM2018_5605.pdf:PDF},
title={Characterize the relaxation effect during the adiabatic radiofrequency ({RF}) pulses on relaxation model for continuous wave constant amplitude spin-lock},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5605.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Weitian Chen and Baiyan Jiang},
abstract={Adiabatic RF pulses can be used for simultaneous compensation of B1 RF and B0 field inhomogeneity during continuous wave constant amplitude spin-lock. However, due to a relatively long duration of the adiabatic RF pulses, the relaxation effect during the adiabatic RF pulses can introduce a non-negligible effect on the conventional mono-exponential model used to describe T1rho relaxation during the spin-lock. Consequently, quantification using the conventional model can introduce errors. Based on Bloch equations, we derived that such relaxation effect contributes a DC component to the conventional mono-exponential model. We used simulation and in vivo MRI scan to demonstrate our theory.}
}
@inproceedings{ISMRM2018_5606,
annote={ISMRM2018_5606},
pages={5606},
file={ISMRM2018_5606.pdf:ISMRM2018_5606.pdf:PDF},
title={Validation of Fat Quantitation in Human Liver using {SSGR} technique},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5606.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Meining Chen and Hai Luo and Beck Zhu and Richard Chou and Chao Wang and Xia Liu and Wei Bian and Ziyue Wu},
abstract={MRI has become the mainstay for noninvasive fat quantification in liver in routine clinical practice. To quantify fat fraction, the Dixon method is used most often. However, it is associated with a nontrivial image reconstruction process. In this study, we aim to perform fat quantification using the slice-selective gradient reversal (SSGR) technique, which was proposed previously but has not been validated in human liver. Our evaluation shows that the technique can efficiently separate water and fat, quantifying fat fraction that is highly correlated with that using the Dixon method.}
}
@inproceedings{ISMRM2018_5607,
annote={ISMRM2018_5607},
pages={5607},
file={ISMRM2018_5607.pdf:ISMRM2018_5607.pdf:PDF},
title={Comparison of two alternative sequences for human in-vivo brain {MR} Current Density Imaging ({MRCDI})},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5607.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Cihan Göksu and Lars G. Hanson and Hartwig R. Siebner and Philipp Ehses and Klaus Scheffler and Axel Thielscher},
abstract={MRCDI is a novel technique, utilizing different phase-sensitive MR methods for non-invasive measurements of weak currents in the human body, which is important in several neuroscience applications. Here, we compare the in-vivo performance of two different MR methods, multi-echo spin echo (MESE) and steady-state free precession free induction decay (SSFP-FID), with single- vs. multi-gradient-echo readouts. We demonstrate that multi-gradient-echo readouts improve both methods. We validate the linear dependence of the measured current-induced magnetic field on the injected current strength for both methods and propose the more efficient SSFP-FID method as being well suited for highly sensitive single-slice human in-vivo MRCDI.}
}
@inproceedings{ISMRM2018_5608,
annote={ISMRM2018_5608},
pages={5608},
file={ISMRM2018_5608.pdf:ISMRM2018_5608.pdf:PDF},
title={Magnitude and Complex Single- and Multi-echo Water Fat Separation via End-to-End Deep Learning},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5608.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={James W Goldfarb and Jie Jane Cao},
abstract={The feasibility of water-fat separation using an end-to-end ConvNet approach was demonstrated for complex, magnitude and single echo acquisitions. The ConvNet approach showed images visually comparable to the GraphCut method with slightly higher signal to noise in typical cardiac image planes. Quantitative PDFF, R2* and off-resonance values had excellent correlation with a conventional analytical model based method. ConvNet based water-fat separation is a promising method capable of learning the water-fat separation problem with corrections for bipolar gradients, a multi-peak model, R2* and off-resonance.}
}
@inproceedings{ISMRM2018_5609,
annote={ISMRM2018_5609},
pages={5609},
file={ISMRM2018_5609.pdf:ISMRM2018_5609.pdf:PDF},
title={Multicenter Validation of the Magnetic Resonance T2* Technique for Quantification of Pancreatic Iron},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5609.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Antonella Meloni and Vincenzo Positano and Daniele De Marchi and Laura Pistoia and Stefania Renne and Riccardo Righi and Paolo Preziosi and Nicolò Schicchi and Massimiliano Missere and Antonino Vallone and Giuseppe Peritore and Ada Riva and Emanuele Grassedonio and Alessia Pepe},
abstract={The gradient-echo T2* MRI technique is an accurate and reproducible means for the calculation of pancreatic iron and may be transferred between MRI scanners in different centers from different manufacturers}
}
@inproceedings{ISMRM2018_5610,
annote={ISMRM2018_5610},
pages={5610},
file={ISMRM2018_5610.pdf:ISMRM2018_5610.pdf:PDF},
title={Robust Water-Fat Separation in Multi-Echo {GRE} Sequence using Patch-Based Neural Network},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5610.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={JaeJin Cho and Kinam Kwon and Seohee So and Byungjai Kim and HyunWook Park},
abstract={The water-fat separation techniques using a multi-echo GRE sequence has suffered from an inaccurate and swapped water-fat separation results caused by several issues. In the abstract, we propose a robust water-fat separation method using patch-based neural network to overcome this problem. The neural network is trained using the relationship between the multi-echo images obtained from the multi-echo GRE sequence and the reliable water-fat separated images that are reconstructed by IDEAL from the multiple single-echo GRE acquisitions with different echo times. The in-vivo experiment results show the proposed method can successfully separate accurate water-fat images from the multi-echo GRE images in comparison with IDEAL.}
}
@inproceedings{ISMRM2018_5611,
annote={ISMRM2018_5611},
pages={5611},
file={ISMRM2018_5611.pdf:ISMRM2018_5611.pdf:PDF},
title={A non-local low rank approach for high resolution parameter mapping},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5611.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Sagar Mandava and Zhitao Li and Diego R Martin and Maria I Altbach and Ali Bilgin},
abstract={Inversion recovery (IR) based single-shot approaches have become popular for rapid T1 mapping. Due to the highly accelerated nature of the acquisition, it is challenging to generate high quality contrast images and T1 maps from this dataset. To tackle this problem, we present a non-local low rank regularization model that is inspired by block matching approaches. For a given relaxation signal, we identify the top L similar relaxation signals within a spatial neighborhood and constrain them to have a low rank. We demonstrate this approach in single-shot high-resolution radial steady-state-free-precession (SSFP) brain and abdomen imaging.}
}
@inproceedings{ISMRM2018_5612,
annote={ISMRM2018_5612},
pages={5612},
file={ISMRM2018_5612.pdf:ISMRM2018_5612.pdf:PDF},
title={Technical Challenges in Measuring Adipose Tissue T2∗},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5612.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Maximilian N. Diefenbach and Franziska Treibel and Daniela Franz and Jan Syväri and Stefan Ruschke and Holger Eggers and Dimitrios C. Karampinos},
abstract={This work investigates the accuracy and precision of T
2∗ estimated from standard water–fat imaging techniques with respect to the a priori assumed fat spectrum. A bias in measuring T
2∗ with a low number of echoes and a mismatch of the a priori to the true fat spectrum is detected. Through simulations and in vivo scans it is shown how the bias is reduced by increasing the number of echoes. Results also indicate remaining inaccuracies due to a mismatch in the assumed fat spectrum to the true fat spectrum in a voxel.}
}
@inproceedings{ISMRM2018_5613,
annote={ISMRM2018_5613},
pages={5613},
file={ISMRM2018_5613.pdf:ISMRM2018_5613.pdf:PDF},
title={Brain Tumor and Prostate {EPI} {MR} Elastography Distortion Reduction and Correction Using r{FOV} and {PSF}-{EPI} Techniques},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5613.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yi Sui and Myung-Ho In and Kay M. Pepin and Kevin J. Glaser and Erin M. Gray and Phillip J. Rossman and Matt A. Bernstein and Richard L. Ehman and John Huston III},
abstract={Image distortion is a common problem in EPI-based MR elastography (MRE) acquisitions, especially in regions with high susceptibility, including regions adjacent to air-tissue interfaces, such as the paranasal sinuses and the prostate. In this study, we explored a reduced-field-of-view (rFOV) technique and a point-spread-function (PSF) mapping EPI correction method to reduce or correct the distortions in EPI MRE images of brain tumors and the prostate.}
}
@inproceedings{ISMRM2018_5614,
annote={ISMRM2018_5614},
pages={5614},
file={ISMRM2018_5614.pdf:ISMRM2018_5614.pdf:PDF},
title={Dual Echo Water-Fat Separation Using Deep Learning},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5614.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Tao Zhang and Yuxin Chen and Shreyas Vasanawala and Ersin Bayram},
abstract={Water-fat separation is widely used in many MR applications and is known to be challenging in various situations. Traditionally, region growing, spatial smoothing and global optimization have been applied in dual echo water-fat separation. These methods require complex-valued images acquired at two echo times and occasionally suffer from global or local swaps due to inaccurate field map estimation. In this work, a deep learning approach for dual echo water-fat separation is investigated.}
}
@inproceedings{ISMRM2018_5615,
annote={ISMRM2018_5615},
pages={5615},
file={ISMRM2018_5615.pdf:ISMRM2018_5615.pdf:PDF},
title={Accuracy of Fatty Acid Quantification using Bipolar Multi-Echo {MRI} for Varying Numbers of Echoes},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5615.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Manuel Schneider and Felix Lugauer and Elisabeth Hoppe and Dominik Nickel and Brian M Dale and Berthold Kiefer and Andreas Maier and Mustafa R Bashir},
abstract={Multi-echo MRI data can be used to quantify the fatty acid composition of human adipose tissue. The total echo train readout length and the number of acquired echoes are important parameters affecting the overall accuracy of the fatty acid parameter maps. The purpose of this study was to quantify the expected error in fatty acid estimates depending on the used total echo train readout length, using an oil phantom at 3T. Echo train readout lengths of at least 13-14ms were required to accurately estimate the different fat components. Shorter echo train readouts led to less accurate parameter maps.}
}
@inproceedings{ISMRM2018_5616,
annote={ISMRM2018_5616},
pages={5616},
file={ISMRM2018_5616.pdf:ISMRM2018_5616.pdf:PDF},
title={Quantitative Assessment of Early Lens Disease in Type 2 Diabetic Patient Using T1 and T2-Mapping},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5616.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ma Junchao and Xu Xiaotong and Wang Shaoyu and Yu Nan},
abstract={This study aimed to explore the feasibility of magnetic resonance T1 and T2 mapping techniques in the evaluation of early complications of lens in type two diabetes mellitus. Patients with type two diabetes mellitus with negative eye slit lamp examination and control group underwent eye MRI scanning, T1 and T2 mapping sequences were collected and two samples t test was used to analyze the differences of T1 and T2 values between groups. The values of T1 and T2 in diabetic group were significantly higher than those in control group. Magnetic resonance T1 and T2 mapping techniques can detect abnormal lens in diabetic patients with negative slit lamp examination.}
}
@inproceedings{ISMRM2018_5617,
annote={ISMRM2018_5617},
pages={5617},
file={ISMRM2018_5617.pdf:ISMRM2018_5617.pdf:PDF},
title={Single Breath-hold 3D T2-weighted b{SSFP} Imaging (T2-{TIDE}) for Treatment Planning on a Low-field {MRI}-guided Radiotherapy System},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5617.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yu Gao and Fei Han and Ziwu Zhou and Jiaxin Shao and Percy Lee and Ann Raldow and Daniel A Low and Yingli Yang and Peng Hu},
abstract={A T2-transition into driven equilibrium (T2-TIDE) technique along with compressed sensing reconstruction was proposed to generate 3D T2-weighted images in a single breath-hold for radiotherapy treatment planning on a low-field MRI-guided radiotherapy system. Phantom and volunteer studies were performed to determine the optimal parameters that provided the best contrast. Five patients with abdominal tumors were recruited to compare the proposed T2-TIDE technique with the conventional bSSFP approach. Improved tumor/organ contrast wereobserved for all five patients, indicating the superior quality of T2-TIDE technique for tumor/organ delineation.}
}
@inproceedings{ISMRM2018_5618,
annote={ISMRM2018_5618},
pages={5618},
file={ISMRM2018_5618.pdf:ISMRM2018_5618.pdf:PDF},
title={T1 and T2 relaxation times of uterus and cervical cancer in vivo at 1.5T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5618.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Xue Wu and Stacie L Mackey and Carol H Bertelsman and Yuan (James) Rao and Jacqueline E Zoberi and Jose Garcia-Ramirez and Perry W Grigsby and Stephanie S Markovina and Julie K Schwarz and Sasa Mutic and H Michael Gach},
abstract={T
1 and T
2 maps were acquired at 1.5 T in three cervical cancer patients (52.3±9.0 years) receiving brachytherapy and external beam radiation therapy. Measurements occurred at weeks 1, 3 and 6, where possible. The average T
1 values were 1448.2 ± 209.1ms in the uterus and 1242.9 ± 202.4 ms in the tumor tissue (cervical carcinoma). The average T
2 values were 86.4 ± 15.6 ms in the uterus and 81.1 ± 20.6 ms in the tumor. There was no significant difference in the T
1 and T
2 in the uterus and tumor based on an analysis of variance.}
}
@inproceedings{ISMRM2018_5619,
annote={ISMRM2018_5619},
pages={5619},
file={ISMRM2018_5619.pdf:ISMRM2018_5619.pdf:PDF},
title={Simultaneous T
1/T
2 Mapping of Hyperpolarized
13C Compounds using the b{SSFP} Sequence},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5619.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Eugene Milshteyn and Galen D. Reed and Jeremy W. Gordon and Peng Cao and Cornelius von Morze and Shuyu Tang and Andrew Leynes and Peder E. Z. Larson and Daniel B. Vigneron},
abstract={Hyperpolarized
13C imaging development has enabled monitoring of different physiological processes, such as metabolism and perfusion, in various diseases, such as cancer and diabetes. The relaxation parameters T
1 and T
2 are essential in sequence optimization and modeling and can be used for assessment of healthy versus diseased tissue. The goal of this project was to develop and apply simultaneous in vivo T
1 and T
2 mapping of hyperpolarized
13C probes using bSSFP sequence. Results indicated multiple approaches can be used to obtain high resolution T
1 and T
2 maps.}
}
@inproceedings{ISMRM2018_5620,
annote={ISMRM2018_5620},
pages={5620},
file={ISMRM2018_5620.pdf:ISMRM2018_5620.pdf:PDF},
title={Magnetization Transfer contrast in in-vivo Locus Coeruleus and Substantia Nigra compared to a Neuromelanin phantom},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5620.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Stan C. J. van Boxel and Nikos Priovoulos and Heidi I.L. Jacobs and Benedikt A. Poser and Dimo Ivanov},
abstract={Magnetization Transfer (MT) MRI has proven valuable in imaging the Locus Coeruleus (LC) and Substantia Nigra (SN). The MT contrast in the LC and SN is assumed to be caused due to the accumulation of neuromelanin. An agar-based phantom containing samples of two neuromelanin models was compared to the in vivo human LC and SN. MT spectra and relaxation times of the phantom, LC and SN were measured. While LC and SN show less MT effect, the phantom does not show neuromelanin-specific MT contrast, suggesting that these models are not representative of the in vivo LC and SN.}
}
@inproceedings{ISMRM2018_5621,
annote={ISMRM2018_5621},
pages={5621},
file={ISMRM2018_5621.pdf:ISMRM2018_5621.pdf:PDF},
title={Liquid Crystal Magnetic Resonance Visible Thermometer},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5621.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Kathryn E Keenan and Elizabeth Mirowski and Michael Snow and Karl F Stupic and Stephen E Russek},
abstract={A magnetic resonance thermometer with liquid crystal compartments was designed and prototyped to provide a method of non-invasively measuring temperature when imaging MR phantoms. We successfully demonstrate the liquid crystal MR visible (LC-MRV) thermometer using different, fast, sequences on both pre-clinical and clinical systems. The LC-MRV thermometer is designed to exhibit rapid cholesteric to isotropic transitions in the room temperature range spanning 15.0°C to 25.0°C in 0.1°C to 1.0°C increments. It is demonstrated that the LC-MRV thermometer is resilient to large magnetic fields and therefore variations in the magnetic field, providing an accurate determination of the temperature during quality control scans where bore temperatures can vary day-to-day and scanner-to-scanner. It also provides a rapid assessment of temperature changes over the duration of the scan.}
}
@inproceedings{ISMRM2018_5622,
annote={ISMRM2018_5622},
pages={5622},
file={ISMRM2018_5622.pdf:ISMRM2018_5622.pdf:PDF},
title={Accuracy of 2D {APT} imaging with short acquisition time based on a self B0 correction using the {TSE}-Dixon method},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5622.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Chiaki Tokunaga and Tatsuhiro Wada and Osamu Togao and Yasuo Yamashita and Kouji Kobayashi and Yoshiyuki Umezu},
abstract={The purpose of our study was to investigate the accuracy of amide proton transfer (APT) imaging using the Dixon method. Five samples were prepared from egg white albumin at the different concentration diluted with phosphate buffer solution. We measured APT signal intensities of the phantoms using the conventional method with separate B0 map and the TSE-Dixon method. No statistical significant differences were found among the APT weighted signals measured with the two different acquisition methods at each concentration. The TSE-Dixon method enabled shorter acquisition time and had an equivalent quantitative accuracy compared to the conventional method with separate B0 mapping.}
}
@inproceedings{ISMRM2018_5623,
annote={ISMRM2018_5623},
pages={5623},
file={ISMRM2018_5623.pdf:ISMRM2018_5623.pdf:PDF},
title={Approximation of Contrast Source for Fast Integral-Based {MR}-{EPT} and the Calculation of Incident Electric Field},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5623.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Lei Guo and Jin Jin and Mingyan Li and Yaohui Wang and Chunyi Liu and Haiwei Chen and Feng Liu and Stuart Crozier},
abstract={Integral-based Magnetic Resonance Electrical Properties Tomography (MR-EPT), has seen rapid development in recent years. Compared with differential-based MR-EPT methods, integral-based methods are less sensitive to measurement noise and free from boundary conditions. The integral-based MR-EPT methods rely on the global convolution between the Green function and the contrast source and also require the knowledge of incident fields. This study investigates a novel method to approximate the contrast source and then utilizes this approximation to calculate the incident electric fields.}
}
@inproceedings{ISMRM2018_5624,
annote={ISMRM2018_5624},
pages={5624},
file={ISMRM2018_5624.pdf:ISMRM2018_5624.pdf:PDF},
title={Monte Carlo Bloch Simulation of T1, T2 uncertainties in {NMR} and {MRI} pulse sequences},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5624.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Stephen E Russek and Michael A Boss and Andrew M Dienstfrey and Zydrunas Gimbutas and Kathryn E Keenan and Jolene D Splett and Karl F Stupic},
abstract={A Monte Carlo Bloch solver has been developed and used to establish the bias and uncertainty of T1, T2 values in primary reference solutions for MRI phantoms. Errors and uncertainties are on the order of 1\% when using a NMR system and robust pulse sequences. Errors and uncertainties in MRI systems are much larger, 5\% to 40\% for T1 values. The Monte Carlo Bloch solver can help determine uncertainties and imperfections in a scanner and then determine the bias and uncertainty of measured biomarkers for different pulse sequences. At present, the source of the large errors and scanner-to-scanner variation in T1 and T2 measured using the NIST/ISMRM system phantom are unknown.}
}
@inproceedings{ISMRM2018_5625,
annote={ISMRM2018_5625},
pages={5625},
file={ISMRM2018_5625.pdf:ISMRM2018_5625.pdf:PDF},
title={Measuring the reproducibility of time-encoded pseudo-continuous arterial spin labeling with a perfusion phantom},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5625.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jeffrey Visser and Aaron Oliver-Taylor and Tom Hampshire and Juan Antonio Hernandez-Tamames and Marion Smits and Xavier Golay and Esther Warnert},
abstract={Arterial Spin Labeling (ASL) is a magnetic resonance imaging (MRI) technique for measuring cerebral blood flow (CBF). Here, we present data on the reproducibility of measuring CBF with time-encoded multi post-labeling delay (PLD) pseudo-continuous ASL (pCASL) in a healthy volunteer compared to a flow phantom. This work shows the potential of using a flow phantom to assess the reproducibility of quantified CBF with ASL.}
}
@inproceedings{ISMRM2018_5626,
annote={ISMRM2018_5626},
pages={5626},
file={ISMRM2018_5626.pdf:ISMRM2018_5626.pdf:PDF},
title={T1 mapping based on Look-Locker and variable-flip-angle techniques: comparison in phantom measurements and in a patient collective},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5626.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Claudia Fellner and Stefanie Pölsterl and Niklas Verloh and Dominik Nickel and Stephan Kannengießer and Philipp Wiggermann and Christian Stroszczynski and Michael Haimerl},
abstract={Two methods for T1 mapping – 2D Look-Locker (LL) and 3D variable-flip-angle (VFA) combined with a 2-point-Dixon technique – were compared in phantom and patient measurements. LL yielded reliable results with homogeneous T1 maps of the liver, but was restricted to 3 slices. VFA yielded T1 mapping of the whole liver, but the homogeneity of T1 values across the liver was reduced which led to marked reduction of mean T1 in some patients compared with LL. The VFA variants based on in-phase and water signals showed differences in T1 for increased hepatic fat.}
}
@inproceedings{ISMRM2018_5627,
annote={ISMRM2018_5627},
pages={5627},
file={ISMRM2018_5627.pdf:ISMRM2018_5627.pdf:PDF},
title={3D isotropic multi-parameter mapping and synthetic imaging of the brain with 3D-{QALAS}: comparison with 2D {MAGIC}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5627.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ken-Pin Hwang and Suchandrima Banerjee and Tao Zhang and Marcel Warntjes},
abstract={3D QALAS is a promising new technique that simultaneously maps T1, T2 and PD in a single 3D acquisition. Both 3D QALAS and 2D MAGIC were applied for synthetic imaging and quantification in human brains. While T1 and T2 values were comparable between the two techniques, 3D QALAS was simpler to process and achieved smaller voxel sizes over larger matrices with similar acquisition times, resulting in less partial volume effects. 2D MAGIC maintained the high in-plane resolution and efficiency of an interleaved multi-slice technique. 3D QALAS thus presents an attractive quantification method for therapy planning and tissue volume measurement applications.
}
}
@inproceedings{ISMRM2018_5628,
annote={ISMRM2018_5628},
pages={5628},
file={ISMRM2018_5628.pdf:ISMRM2018_5628.pdf:PDF},
title={3D multi-parameter mapping of the breast with Dixon fat-water separation},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5628.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ken-Pin Hwang and Jong Bum Son and Suchandrima Banerjee and Tao Zhang and Jingfei Ma and Gaiane Margishvili Rauch and Marcel Warntjes},
abstract={3D QALAS is a promising new technique that simultaneously maps T1, T2 and PD in a single 3D acquisition. However, the presence of fat can confound multi-parameter mapping of voxels with mixed species. We modified the sequence to acquire dualecho readouts and apply a joint field map estimation across all echoes to produce water-only images for multi-parameter fitting. The technique was applied in the breast and parameter maps were compared with those generated from a 2D unsuppressed acquisition. By eliminating partial volume effects of fat, the technique potentially extends the use of 3D multi-parameter mapping into body, breast and spine.}
}
@inproceedings{ISMRM2018_5629,
annote={ISMRM2018_5629},
pages={5629},
file={ISMRM2018_5629.pdf:ISMRM2018_5629.pdf:PDF},
title={Comparison of reconstruction algorithms for quantitative susceptibility mapping in the upper abdomen},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5629.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Taisuke Harada and Kohsuke Kudo and Ryota Sato and Masato Yoshikawa and Satoshi Yabusaki and Toru Shirai and Yoshitaka Bito},
abstract={We compared three QSM reconstruction algorithms for use in the upper abdomen: the water-fat separation method (WF), MUDICK and iLSQR. A healthy male was scanned nine times, in different positions and three QSM reconstructions from the same source data were compared. The intra-scan SD, representing image homogeneity among images and the inter-scan SD, representing repeatability among scans, were lower in WF than in MUDICK and iLSQR. Thus, the WF method yielded better homogeneity and repeatability for susceptibility values in the upper abdomen. This forms the basis for further clinical studies and applications of QSM in the abdomen.}
}
@inproceedings{ISMRM2018_5630,
annote={ISMRM2018_5630},
pages={5630},
file={ISMRM2018_5630.pdf:ISMRM2018_5630.pdf:PDF},
title={Fast 3D Multi-Parameter Mapping of Relaxation Times and Susceptibility Using Partially {RF}-Spoiled Gradient Echo at 3T},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5630.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yo Taniguchi and Suguru Yokosawa and Toru Shiraii and Ryota Sato and Tomoki Amemiya and Hisaaki Ochi and Yoshihisa Soutome},
abstract={A method is presented to simultaneously quantify multiple tissue parameters, including susceptibility, by using a partially RF-spoiled gradient echo sequence. The method successfully obtained whole-brain T1, T2*, PD, B1 and susceptibility maps in 1.1-mm isotropic resolution in 12 minutes at 3T. T1, T2*, PD and B1 maps were estimated simultaneously by a least-squares fit using twelve 3D source images. The intensity function for the fit was formulated by Bloch simulations. Scan parameters were optimized for T1 and T2* values of the brain at 3T. The susceptibility map was estimated by using six multi-echo images in the source images.}
}
@inproceedings{ISMRM2018_5631,
annote={ISMRM2018_5631},
pages={5631},
file={ISMRM2018_5631.pdf:ISMRM2018_5631.pdf:PDF},
title={Robust {PD} mapping using multi-contrast variable flip angle ({VFA}) data},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5631.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Sara Lorio and Tim Tierney and Amy McDowell and Owen Arthurs and Antoine Lutti and Nikolaus Weiskopf and David W. Carmichael},
abstract={Proton density (PD) maps measure the amount of free water molecules in the tissue and can be used in a range of neurological disorders. However, current PD estimation methods in the brain rely on anatomical prior information which can be problematic in the case of severe tissue abnormalities. Here we propose a new approach for PD mapping based on a multi-contrast acquisition protocol and a data-driven estimation method for inhomogeneity correction and map scaling. This approach can be applied on ex-vivo samples and in case of pronounced brain pathology because it does not require any anatomical nor tissue information.}
}
@inproceedings{ISMRM2018_5632,
annote={ISMRM2018_5632},
pages={5632},
file={ISMRM2018_5632.pdf:ISMRM2018_5632.pdf:PDF},
title={Validation of a quantitative susceptibility mapping acquisition and reconstruction pipeline using a new iron sucrose based {MR} susceptibility phantom.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5632.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Jeremy Deverdun and Francois Molino and Nicolas Menjot de Champfleur and Emmanuelle Le Bars},
abstract={Quantitative susceptibility mapping (QSM) is a new technique and it has been shown that results can vary according to the MRI device, phase reconstruction and susceptibility estimation algorithms. Porting this mapping on the clinical practice would be of interest in numerous kind of pathology. However, it requires a validation which should be performed using a dedicated MR phantom. We described an easy to build MR susceptibility phantom based on iron sucrose. Using optimal parameters, the quantitative susceptibility mapping provides a very good estimation of the iron concentrations in the phantom.}
}
@inproceedings{ISMRM2018_5633,
annote={ISMRM2018_5633},
pages={5633},
file={ISMRM2018_5633.pdf:ISMRM2018_5633.pdf:PDF},
title={Higher-order subspace denoising for improved multi-contrast imaging and parameter mapping},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5633.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Sagar Mandava and Mahesh B Keerthivasan and Diego R Martin and Maria I Altbach and Ali Bilgin},
abstract={Multi-contrast image acquisitions are valuable for diagnostics but the scan time scales with the number of contrast images. Accelerated acquisitions are necessary for practical scan times and require the use of constrained reconstructions. Subspace-constraints, which constrain the multi-contrast data to lie in a low-dimensional subspace, are popularly used to reconstruct these datasets. Despite yielding good quality images at most imaging contrasts, these constraints create poor image quality at certain contrasts. We demonstrate that this is due to poor recovery of higher order subspace coefficients and present a model to enable high quality recovery of these coefficients and consequently the echo-images.}
}
@inproceedings{ISMRM2018_5634,
annote={ISMRM2018_5634},
pages={5634},
file={ISMRM2018_5634.pdf:ISMRM2018_5634.pdf:PDF},
title={Rapid B1 mapping based on the Bloch-Siegert shift using a single offset frequency and multi-echo readout},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5634.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Nadège Corbin and Julio Acosta-Cabronero and Oliver Josephs and Nikolaus Weiskopf and Martina F Callaghan},
abstract={The advance towards in vivo histology benefits greatly from the quantification of specific physical parameters
1. The longitudinal relaxation rate (R
1) has proven a reliable surrogate for myelination, facilitating investigation of the relationship between brain microstructure and function in vivo
2–5. R
1 maps can be estimated by combining spoiled gradient-echo volumes, acquired with variable flip angles and calibration data correcting for flip angle inhomogeneities. The Bloch-Siegert shift (BSS) approach
6 is a relatively time-efficient method that allows the calibration data to be acquired with an identical gradient-echo readout thereby matching distortions across all data needed to map R
1. However, it requires data to be acquired at two off-resonance frequencies to remove B
0 dependence up to second order and suffers from high specific-absorption-rate (SAR). Here, we investigate a modified BSS-based B
1+ mapping approach that aimed to overcome these shortcomings by using a single offset frequency and a multi-echo readout.}
}
@inproceedings{ISMRM2018_5635,
annote={ISMRM2018_5635},
pages={5635},
file={ISMRM2018_5635.pdf:ISMRM2018_5635.pdf:PDF},
title={{SCOPE}-T1ρ: Signal Compensation for Low-rank Plus Sparse Matrix Decomposition for Fast T1ρ Mapping},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5635.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yuanyuan Liu and Yanjie Zhu and Leslie Ying and Yi-Xiang J Wang and Jing Yuan and Xin Liu and Dong Liang},
abstract={Quantitative T
1ρ mapping typically requires the acquisition of multiple images with different spin-lock times, which greatly prolongs the scanning time, limiting its clinical applications. We developed a novel reconstruction method using a low-rank plus sparse model to obtain the parameter-weighted images from highly undersampled k-space data. This method exploited both the parameter-weighted image properties and priori information from the parameter model. Specifically, a signal compensation strategy was introduced to promote the low rankness along the parametric direction. The proposed method achieved a five-fold acceleration in the acquisition time and obtained more accurate T
1ρ maps than the existing methods.}
}
@inproceedings{ISMRM2018_5636,
annote={ISMRM2018_5636},
pages={5636},
file={ISMRM2018_5636.pdf:ISMRM2018_5636.pdf:PDF},
title={High Resolution T1 quantification from golden-angle radial 3D acquisitions.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5636.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Oliver Maier and Matthias Schloegl and Jasper Schoormans and Bram Coolen and Tobias Block and Thomas Benkert and Gustav Strijkers and Rudolf Stollberger},
abstract={A model-based reconstruction approach is presented that allows time efficient encoding of radial data for high resolution 3D T1 quantification e.g. (256x256x52, 1mm
3, t
scan=96s) by exploiting structural similarities in 3D and between different parameter maps. The proposed method employs a 3D TGV-Frobenius regularization to achieve high quality parameter maps from 3D VFA and 3D IRLL data. A dedicated reconstruction framework, consisting of an iteratively-regularized Gauss-Newton algorithm combined with a Primal-Dual splitting is employed to solve the optimization problem. Reconstructed parameter maps exhibit high SNR and no residual streaking artifacts while reconstructed T1 values agree well with reported values from literature.}
}
@inproceedings{ISMRM2018_5637,
annote={ISMRM2018_5637},
pages={5637},
file={ISMRM2018_5637.pdf:ISMRM2018_5637.pdf:PDF},
title={Quantifying Perfusion Properties with {DCE}-{MRI} Using a Dictionary Matching Approach},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5637.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Satyam Ghodasara and Sam Frankel and Yong Chen and Mark Griswold and Nicole Seiberlich and Vikas Gulani and Katherine Wright},
abstract={ To overcome the shortcomings of curve fitting to quantify perfusion properties, a dictionary matching approach like that used in magnetic resonance fingerprinting is proposed. This dictionary matching approach could be used for any DCE application or model, but is demonstrated and validated here for a dual-input single-compartment model of liver DCE-MRI data. The dictionary matching method provides similar results to the curve fitting method while being simpler to implement and dramatically faster. }
}
@inproceedings{ISMRM2018_5638,
annote={ISMRM2018_5638},
pages={5638},
file={ISMRM2018_5638.pdf:ISMRM2018_5638.pdf:PDF},
title={{ST}imulated Echo based Mapping ({STEM}) of T1, T2 and Apparent Diffusion Coefficient},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5638.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Yuxin Zhang and Xiaoke Wang and Valentina Taviani and Diego Hernando},
abstract={This study proposed an approach for joint estimation of T1 and T2 relaxation as well as quantitative diffusion parameters. The proposed approach has been evaluated in quantitative relaxation-diffusion phantom, in-vivo brain imagingand prostate imaging. The overall T1, T2and ADC measurements have been shown to be accurate compared to reference maps. In this feasibility study, the acquisition was over-sampled in TM-TE-b space, which limited the scan time. Future work will introduce undersampling and protocol optimization. In summary, this method has the potential to enable multi-dimensional tissue characterization in clinically feasible acquisition times.}
}
@inproceedings{ISMRM2018_5639,
annote={ISMRM2018_5639},
pages={5639},
file={ISMRM2018_5639.pdf:ISMRM2018_5639.pdf:PDF},
title={Single-shot multi-slice T1 mapping using inversion recovery radial {FLASH} and model-based reconstruction},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5639.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Xiaoqing Wang and Dirk Voit and Volkert Roeloffs and Martin Uecker and Jens Frahm},
abstract={Fast quantitative T1 mapping can be achieved within a single inversion recovery based on recent advances in real-time MRI and/or model-based reconstructions. However, efforts have been mainly focused on single-slice T1 mapping. To further take advantage of inherent data redundancy, we propose a single-shot high-resolution multi-slice T1 mapping technique which bases on a spoke-interleaved radial FLASH data acquisition scheme and a recent proposed model-based reconstruction technique. Initial results show that we could achieve high resolution seven-slice human brain T1 maps or three-slice abdominal T1 maps within 4 seconds.}
}
@inproceedings{ISMRM2018_5640,
annote={ISMRM2018_5640},
pages={5640},
file={ISMRM2018_5640.pdf:ISMRM2018_5640.pdf:PDF},
title={Online Free-Breathing Liver Perfusion Imaging Using Parallel Computing and the Gadgetron Framework},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5640.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Kun Yang and Yong Chen and Satyam Ghodasara and Wei-Ching Lo and Yun Jiang and Nicole Seiberlich and Katherine Wright and Vikas Gulani},
abstract={Accelerated image acquisition, advanced reconstruction and registration methods and perfusion modeling have recently enabled free-breathing and quantitative 4D DCE MRI in the liver. However, the reconstruction, registration and model fitting steps are performed offline as they are time consuming; each data set takes more than a day to analyze. This makes quantitative 3D liver perfusion unsuitable for clinical deployment. We propose using a GPU-based Gadgetron framework for parallelized and near-immediate provision of all data, including a Spiral GRAPPA reconstruction, non-rigid image registration and pharmacokinetic modeling using a dictionary-based approach. This approach reduces the reconstruction time from hours to minutes.}
}
@inproceedings{ISMRM2018_5641,
annote={ISMRM2018_5641},
pages={5641},
file={ISMRM2018_5641.pdf:ISMRM2018_5641.pdf:PDF},
title={Simultaneous mapping of R2*, T1 and proton density fat fraction for the liver: single breath-hold acquisition with multi-echo spoiled gradient echo and compressed sensing},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5641.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Daiki Tamada and Tetsuya Wakayama and Utaroh Motosugi and Hiroshi Onishi},
abstract={In this study, we developed multi-parameter mapping including T1, R2* and proton density fat fraction with a single breath-hold, to evaluate liver disease and liver function. Six-echo spoiled gradient echo sequence with dual flip angles was used to acquire a 12-set MRI volume dataset. To shorten the scan time, undersampling and multi-contrast compressed sensing reconstruction were used. Quantitative values were validated by performing phantom and volunteer studies.}
}
@inproceedings{ISMRM2018_5642,
annote={ISMRM2018_5642},
pages={5642},
file={ISMRM2018_5642.pdf:ISMRM2018_5642.pdf:PDF},
title={Information Theory Quantification of Acquisition Parameter Impact on Synthetic {MRI} Reconstruction Uncertainty},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5642.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Drew Mitchell and David Fuentes and Tao Zhang and Ken-Pin Hwang},
abstract={We develop a mutual information-based mathematical framework to quantify the information content of a parameter space composed of several pulse sequence acquisition parameters of interest for model-based image reconstruction. We apply this framework to the signal model for a multi-contrast inversion- and T2-prepared gradient echo sequence. Mutual information between parametric map uncertainty and measured data is determined for variable acquisition parameters to characterize the performance of each acquisition. This framework allows for the strategic selection of synthetic MR acquisition parameters for specific applications and also provides a quantitative understanding of parameter space information content in an acquisition for multi-parameter mapping.}
}
@inproceedings{ISMRM2018_5643,
annote={ISMRM2018_5643},
pages={5643},
file={ISMRM2018_5643.pdf:ISMRM2018_5643.pdf:PDF},
title={Simultaneous T1 and T2 parametric mapping and synthetic {MRI} with {IR}-prepared echo-split gradient-echo and spin-echo imaging and parametric {POCSMUSE} reconstruction},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5643.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Mei-Lan Chu and Nan-kuei Chen},
abstract={Our novel simultaneous T1 and T2 mapping framework, integrating IR-prepared echo-split GRASE acquisition and parametric POCSMUSE reconstruction, has the following advantages. First, T1 and T2 maps can be derived from four sets of single-shot IR-prepared echo-split GRASE data, with very high scan efficiency. Second, T1 and T2 relaxation time constants can be accurately measured by the parametric POCSMUSE algorithm, which models multiplexed signals across CPMG echoes and multiple IR-prepared data of multi-echo-pathway. Third, synthetic multi-contrast images can be generated from the measured parametric maps.}
}
@inproceedings{ISMRM2018_5644,
annote={ISMRM2018_5644},
pages={5644},
file={ISMRM2018_5644.pdf:ISMRM2018_5644.pdf:PDF},
title={Improved quantification of cerebral blood flow in gray matter and white matter using non-Fourier based reconstruction},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5644.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Phil Lee and Peter Adany and In-Young Choi},
abstract={Accurate quantification of CBF in GM and WM is challenging due to intrinsically low SNR and low spatial resolution of CBF maps. In this study we propose a new approach in quantifying CBF in GM and WM, based on spectral localization by imaging (SLIM), which provides accurate CBF values in compartments with complex shapes, e.g., GM and WM by incorporating high-resolution anatomical information into CBF reconstruction at reduced scan time.}
}
@inproceedings{ISMRM2018_5645,
annote={ISMRM2018_5645},
pages={5645},
file={ISMRM2018_5645.pdf:ISMRM2018_5645.pdf:PDF},
title={Spectral Model Dependent Quantification of Triglyceride Composition using Chemical Shift Encoded Magnetic Resonance Imaging},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5645.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Gregory Simchick and Amelia Yin and Hang Yin and Qun Zhao},
abstract={Dynamic processes such as brown adipose tissue (BAT) activation and white adipose tissue (WAT) beiging have been shown to change triglyceride composition. Therefore, accurate spatial quantification of triglyceride composition is important for the monitoring of these processes. Presented here is an evaluation of the performance of various fat spectral models on the quantification of triglyceride composition using chemical shift encoded magnetic resonance imaging (CSE-MRI). Variations as large as 45\% and less than 2.82\% are observed in the average estimations of triglyceride composition and proton density fat fraction (PDFF), respectively. Estimations obtained using a material specific model correlate better with spectroscopy estimations than other examined models.}
}
@inproceedings{ISMRM2018_5646,
annote={ISMRM2018_5646},
pages={5646},
file={ISMRM2018_5646.pdf:ISMRM2018_5646.pdf:PDF},
title={An investigation into the effect of body composition on the agreement between whole-body fat mass determined by {MRI} and air-displacement plethysmography.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5646.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Andrew Weedall and Adrian Wilson and Sarah Wayte},
abstract={The agreement between whole-body fat mass determined using MRI and air-displacement plethysmography (ADP) was investigated for a range of non-pathological body mass indexes (BMIs). The whole-body fat mass was determined for ten volunteers by two methods: firstly by ADP using a BODPOD
®; and secondly using two different MRI sequences (LAVA-flex and IDEAL IQ). The whole-body fat mass determined by both MRI protocols showed good agreement with, but were consistently higher than, the ADP determination (mean difference: LAVA-flex=4±3kg; IDEAL IQ=2±3kg). In addition, analysis of Bland-Altman plots showed no change in the differences between the MRI and ADP fat mass with BMI.}
}
@inproceedings{ISMRM2018_5647,
annote={ISMRM2018_5647},
pages={5647},
file={ISMRM2018_5647.pdf:ISMRM2018_5647.pdf:PDF},
title={Linear B1-Dependent Correction of Quantitative in vivo T2 Maps Acquired with Fast Spin Echo Techniques},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5647.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ulrike Nöth and Manoj Shrestha and Jan-Rüdiger Schüre and Ralf Deichmann},
abstract={A method is proposed for correcting the effects of stimulated echoes in T2 mapping based on fast spin echo sequences. In contrast to existing techniques, the proposed method does not require a priori knowledge of the radio frequency pulse profiles. A linear relationship between uncorrected apparent T2 (T2app) and corrected T2 values with B1-dependent regression parameters was found which facilitates the conversion of T2app into T2 maps. In vivo results show that corrected T2 values correspond closely to reference values and have an improved consistency across protocols.}
}
@inproceedings{ISMRM2018_5648,
annote={ISMRM2018_5648},
pages={5648},
file={ISMRM2018_5648.pdf:ISMRM2018_5648.pdf:PDF},
title={{MR} Thermometry in Phantoms Using Bulk Magnetic Susceptibility},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5648.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Scott Swanson and Dariya Malyarenko and Thomas Chenevert},
abstract={We have developed a phantom for absolute temperature measurement based on the bulk magnetic susceptibility (BMS) of solutions of paramagnetic ions. This work shows that a solution of 150 mM dysprosium creates a BMS shift of approximately 0.09 ppm/°C.}
}
@inproceedings{ISMRM2018_5649,
annote={ISMRM2018_5649},
pages={5649},
file={ISMRM2018_5649.pdf:ISMRM2018_5649.pdf:PDF},
title={Improved Accuracy of Accelerated 3D T2* Mapping with Coherent Parallel Maximum Likelihood Estimation},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5649.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Wajiha Bano and Mohammad Golbabee and Arnold Julian Vinoj Benjamin and Ian Marshall and Michael Davies},
abstract={We propose an approach that can reconstruct isotropic T2* Maps from undersampled data with improved accuracy by utilizing the phase information. Our approach extends the acceleration attained in Parallel Imaging(PI) to Maximum Likelihood Estimation (MLE) by imposing the exponential relaxation directly in the complex signal domain. The method was tested on a Multiecho Gradient Echo(MEGE) T2* mapping experiment in a numerical phantom and a human brain with realtime (prospective) undersampling. The approach showed that incorporating the phase information to perform coherent fitting resulted in better denoising and improved accuracy of the parametric maps.}
}
@inproceedings{ISMRM2018_5650,
annote={ISMRM2018_5650},
pages={5650},
file={ISMRM2018_5650.pdf:ISMRM2018_5650.pdf:PDF},
title={Correction for insufficient spoiling of transverse magnetization in T1 mapping based on the variable flip angle technique},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5650.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Simon Baudrexel and Ulrike Noeth and Jan-Ruediger Schuere and Ralf Deichmann},
abstract={A method is proposed for the correction of insufficient spoiling of transverse magnetization components in gradient echo data that are used for T1 quantification via the variable flip angle (VFA) approach. The method is based on the use of modified flip angles in the VFA algorithm that differ from the actual angles. The advantage is the versatility of the proposed method: from a given set of 21 values P(k,l), suitable correction parameters can be derived for any VFA protocol. In vitro and in vivo experiments show that this novel correction technique considerably increases the accuracy of measured T1 values.}
}
@inproceedings{ISMRM2018_5651,
annote={ISMRM2018_5651},
pages={5651},
file={ISMRM2018_5651.pdf:ISMRM2018_5651.pdf:PDF},
title={Controlling magnetisation transfer and exchange effects in mc{DESPOT} relaxometry.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5651.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Daniel J. West and Rui Pedro A. G. Teixeira and Jacques-Donald Tournier and Joseph V. Hajnal and Shaihan J. Malik},
abstract={Magnetisation transfer (MT) has been found to contribute to parameter estimation bias in sequences used in the two-pool relaxometry technique, mcDESPOT. Recent work shows that using controlled saturation magnetisation transfer (CSMT) RF-pulses, a two-pool system (free- and bound-pools) can behave as a single pool with modified equilibrium magnetisation and longitudinal relaxation rate. Here, we investigate the use of CSMT to model MT-effects in a three-pool system (exchange + MT) and show that under these conditions, signal behaves as a two-pool system and matches a mcDESPOT model but characterised by different parameters than those originally assumed.
}
}
@inproceedings{ISMRM2018_5652,
annote={ISMRM2018_5652},
pages={5652},
file={ISMRM2018_5652.pdf:ISMRM2018_5652.pdf:PDF},
title={Geometry in {MR} Reconstruction},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5652.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={David Atkinson and Muhammad Usman and Lebina Kakkar and Simon Arridge},
abstract={Keeping track of positional information, from planning the position of a field of view, through to the final reconstructed image can be challenging. This educational poster highlights some of the issues and pitfalls in the acquisition and reconstruction process. Use of DICOM-style spatial referencing is encouraged and strategies for validation are presented.}
}
@inproceedings{ISMRM2018_5653,
annote={ISMRM2018_5653},
pages={5653},
file={ISMRM2018_5653.pdf:ISMRM2018_5653.pdf:PDF},
title={Implementation of total variation ({TV}) calculation for compressed sensing {MRI} – options, algorithms and reconstruction results},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5653.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Olaf Dietrich and Thomas Gaass and Maximilian F Reiser},
abstract={Compressed-sensing (CS) MRI is frequently based on the minimization of an objective function consisting of the $\ell_1$-norm of a sparse image representation and the total variation (TV) of the image. Various definitions of the TV exist (isotropic/anisotropic; first-order/second-order/combined; and, particularly for complex-valued image data, several ways of dealing with real and imaginary parts of the image). The purpose of this abstract is to explain these variants, to provide implementation details and to compare several variants with respect to CS reconstruction.
}
}
@inproceedings{ISMRM2018_5654,
annote={ISMRM2018_5654},
pages={5654},
file={ISMRM2018_5654.pdf:ISMRM2018_5654.pdf:PDF},
title={Serial Quantitative Brain T1 Hyper-intensity Changes in Pediatric Patients Before and After Switching from Linear to Macrocyclic {MRI} Contrast Agents.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5654.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Amber Pokorney and Ryan Robison and Jeffrey Miller},
abstract={The purpose of this study is to investigate the effect of switching from a linear to a macrocyclic GBCA on T1 signal enhancement in unenhanced T1-weighted brain images of pediatric patients. As in previous studies, significant signal intensity differences were observed in patients in the dentate nucleus and globus pallidus following serial administrations of a linear GBCA. In this study, a significant reduction in these signal intensities was also observed in these patients following several subsequent doses of a macrocyclic GBCA.}
}
@inproceedings{ISMRM2018_5655,
annote={ISMRM2018_5655},
pages={5655},
file={ISMRM2018_5655.pdf:ISMRM2018_5655.pdf:PDF},
title={Calibration strategies for quantitative 2D {EPI} p{CASL} analysis},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5655.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Wibeke Nordhøy and Øystein Bech Gadmar and Atle Bjørnerud},
abstract={This study evaluates different methods of calibrating pseudo-continuous ASL images for quantification of cerebral blood flow in the brain; homogeneity correction strategies and the dual inversion recovery background suppression efficacy of 2D-EPI pCASL were examined.}
}
@inproceedings{ISMRM2018_5656,
annote={ISMRM2018_5656},
pages={5656},
file={ISMRM2018_5656.pdf:ISMRM2018_5656.pdf:PDF},
title={An Update on Synthetic {MRI} in Pediatric Brains; Including a Review of {MR} Quantification Method, Features of the Sy{MRI} Software and Clinical Applications},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5656.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Christina Andica and Akifumi Hagiwara and Moeko Horita and Misaki Nakazawa and Tomoko Maekawa and Saori Koshino and Masaaki Hori and Lydia Chougar and Shigeki Aoki},
abstract={The use of synthetic MRI, a multi-parametric quantitative MRI, in the pediatric population has been increased dramatically in the recent years showing promising results. With this approach, it is possible to synthesize any contrast-weighted images, to obtain automatic brain segmentation and volumetry and to evaluate the myelin in a single scan. The image quality of synthetic images has been shown comparable to that of conventional MR images and the features of synthetic MRI might be used to investigate children brain development and diseases. In this exhibit, we aim to show the recent updates of synthetic MRI in pediatric brain imaging.}
}
@inproceedings{ISMRM2018_5657,
annote={ISMRM2018_5657},
pages={5657},
file={ISMRM2018_5657.pdf:ISMRM2018_5657.pdf:PDF},
title={Applications and Pitfalls of Arterial Spin Labeling Brain Perfusion in Pediatrics},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5657.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Arastoo Vossough},
abstract={Arterial spin labeling (ASL) perfusion has lots of utility in pediatric neuroimaging, but is also prone to interpretive pitfalls that require good understanding of the technical MRI principles of the technique. The clinical utility, advantages, technical limitations and pitfalls of ASL in the pediatric population will be presented in the context of select neurological disorders of children.}
}
@inproceedings{ISMRM2018_5658,
annote={ISMRM2018_5658},
pages={5658},
file={ISMRM2018_5658.pdf:ISMRM2018_5658.pdf:PDF},
title={The combined use of {MRI} and {PET} for the characterisation and treatment planning of masses in neuro-oncology},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5658.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Arian Lasocki and Rod Hicks},
abstract={MRI is the standard of care for most neuroimaging indications and advanced sequences are providing an ever-growing ability for lesion characterisation. PET is widely used in oncology and the limitations of Fluorine-18 fluorodeoxyglucose in neuro-oncology have been overcome by the development of novel PET tracers. The sequential use of these modalities harnesses the strengths of both and has led to the development of combined PET-MR systems. This educational exhibit demonstrates the ways in which MRI and PET can be used in a complementary manner for improved lesion characterisation in neuro-oncology, including diagnosis and treatment planning.}
}
@inproceedings{ISMRM2018_5659,
annote={ISMRM2018_5659},
pages={5659},
file={ISMRM2018_5659.pdf:ISMRM2018_5659.pdf:PDF},
title={Fast Neuro {MRI} with Variable Refocusing Flip-Angle 2D {SSFSE}},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5659.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Karl K Vigen and Daniel V Litwiller and James C Darsie and James H Holmes and Susan Rebsamen and Justin L Brucker and Aaron S Field and Howard A Rowley},
abstract={A variable refocusing flip-angle method is described for 2D Single-Shot Fast Spin Echo (SSFSE) for fast imaging of the brain and spine, which can be beneficial in pediatric populations to avoid sedation and repeated CT exams. The scheme allows for full-Fourier k-space acquisitions with improved sharpness and T2 contrast and faster imaging compared with conventional SSFSE.}
}
@inproceedings{ISMRM2018_5660,
annote={ISMRM2018_5660},
pages={5660},
file={ISMRM2018_5660.pdf:ISMRM2018_5660.pdf:PDF},
title={The role of driver mutations in pediatric diffuse gliomas with histone H3 K27M mutation},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5660.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Mariam Aboian and Soonmee Cha},
abstract={In this educational exhibit we will describe the imaging features of the new diagnostic entity based on 2016 CNS WHO classification – diffuse midline glioma with histone H3 K27M mutation. We will review the genetics of these tumors and will describe the common driver mutations that are detected. We will contrast the molecular signature of these tumors to hemispheric gliomas that have different imaging features and different outcomes.}
}
@inproceedings{ISMRM2018_5661,
annote={ISMRM2018_5661},
pages={5661},
file={ISMRM2018_5661.pdf:ISMRM2018_5661.pdf:PDF},
title={Do you suffer from long-term memory loss? I don't remember...: An {MRI} pictorial review of neurodegenerative diseases},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5661.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Ing Berne Yeh and Sze Yiun Teo and Saurav Gupta and Joo Hong Chuah},
abstract={Neurodegenerative diseases are a large group of conditions with progressive, but variable, neurological deterioration over time. Dementia is a hallmark in many of these diseases. Classification using clinical phenotypes is suboptimal due to broad overlap in clinical manifestations and recent approaches have favoured using neuropathological and biochemical criteria instead. Neuroimaging using magnetic resonance imaging (MRI) has good correlation with the neuropathological classification and can be used to aid the clinician in making an accurate diagnosis. This education exhibit provides an MRI pictorial review of the neurodegenerative diseases which are more common and/or are more clearly defined from a neuropathological standpoint.
}
}
@inproceedings{ISMRM2018_5662,
annote={ISMRM2018_5662},
pages={5662},
file={ISMRM2018_5662.pdf:ISMRM2018_5662.pdf:PDF},
title={Spectrum of Ovarian Diseases with Hypo-signal on Fat Suppressed T2{WI} ({FS} T2): Radiologic-pathologic Correlation},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5662.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={XU HAN and MEI-YU SUN and MENG-YAO WANG and RUI FAN},
abstract={To assess the ovarian tumors with hypo-signal on fat suppressed T2WI and to summarize their MRI features, which can expand the spectrum of disease.
}
}
@inproceedings{ISMRM2018_5663,
annote={ISMRM2018_5663},
pages={5663},
file={ISMRM2018_5663.pdf:ISMRM2018_5663.pdf:PDF},
title={Configuration Model},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5663.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Carl Ganter},
abstract={Extended phase graphs (EPG) accurately describe the appearance of echoes and their respective amplitudes for virtually any MR sequence. Due to the common definition of EPG states, however, there are shortcomings when it comes to quantify susceptibility effects and the relevance of echo pathways. This Educational E-Poster dicusses the origin of these limitations and how they can be resolved within the closely related microscopic configuration model (CM).}
}
@inproceedings{ISMRM2018_5664,
annote={ISMRM2018_5664},
pages={5664},
file={ISMRM2018_5664.pdf:ISMRM2018_5664.pdf:PDF},
title={Accurate and precise {MRI} relaxometry: the often disregarded but critical role of statistical parameter estimation},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5664.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Gabriel Ramos-Llordén and Quinten Beirinckx and Arnold J. den Dekker and Jan Sijbers},
abstract={In this educational poster, we emphasize the critical role that statistical parameter estimation plays in turning MRI relaxometry into an accurate and precise qMRI modality. In this longstanding goal, most of the efforts have been made on deriving more accurate physical models, but, to the authors’ knowledge, the importance of using modern statistical parameter estimation methods has been overlooked. Here, we present "the do's and the don’ts" of statistical parameter estimation for quantitative MRI relaxometry, illustrating all the concepts with real-case scenarios.
}
}
@inproceedings{ISMRM2018_5665,
annote={ISMRM2018_5665},
pages={5665},
file={ISMRM2018_5665.pdf:ISMRM2018_5665.pdf:PDF},
title={Quantitative information derived from {MRS} lineshapes affected by material heterogeneity - principles, applications and future potential in biomedicine},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5665.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Norbert W. Lutz and Monique Bernard},
abstract={
Quantifying tissue heterogeneity is a major challenge in biomedical MRS and MRI. We present here a review of several closely related recent methods for deriving, from MRS lineshapes via histograms, quantitative statistical information on heterogeneity and point out current and future biomedical applications. At present, heterogeneity in parameters such as ion concentrations (H+, Ca2+, Mg2+, Na+) are being targeted, but also thermal heterogeneity (relevant to hyperthermia) has been proven to be accessible to this type of spectral analysis. Future in-vivo studies are expected to benefit from the wider window into the regulation of physicochemical parameters, enabled by the new underlying paradigm. }
}
@inproceedings{ISMRM2018_5666,
annote={ISMRM2018_5666},
pages={5666},
file={ISMRM2018_5666.pdf:ISMRM2018_5666.pdf:PDF},
title={{INSPECTOR} - A Tool for Teaching Magnetic Resonance Spectroscopy},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5666.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Christoph Juchem},
abstract={Magnetic resonance spectroscopy (MRS) is a powerful tool for biomedical research and clinical diagnostics of virtually all disorders that possess distinct metabolic signatures. The importance of literacy in MRS data analysis and interpretation thus cannot be overstated. INSPECTOR is a graphical user interface (GUI)-based software package for MRS data quality assessment, processing and analysis with visualization capabilities that make it ideal for educational settings. Here I discuss the suitability of INSPECTOR for hands-on learning of MRS processing and quantification strategies.}
}
@inproceedings{ISMRM2018_5667,
annote={ISMRM2018_5667},
pages={5667},
file={ISMRM2018_5667.pdf:ISMRM2018_5667.pdf:PDF},
title={Preclinical {MR} spectroscopy for studies of in vivo myocardial energy metabolism in heart failure},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5667.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Desiree Abdurrachim and Adrianus J Bakermans and Klaas Nicolay and Philip Teck Hock Lee and Jeanine J Prompers},
abstract={Changes in myocardial energy metabolism have been thought to contribute to the development of heart failure. Here, we will review methods and applications of cardiac 1H MRS, 31P MRS and hyperpolarized 13C MRS techniques in probing myocardial energy metabolism in vivo in small animal models of heart failure.}
}
@inproceedings{ISMRM2018_5668,
annote={ISMRM2018_5668},
pages={5668},
file={ISMRM2018_5668.pdf:ISMRM2018_5668.pdf:PDF},
title={Hybrid 18F {FDG} {PET}/{MRI} in imaging cardiac sarcoidosis: a case based review.},
url={http://indexsmart.mirasmart.com/ISMRM2018/PDFfiles/5668.html},
booktitle={Proc. Joint Annual Meeting ISMRM-ESMRMB, Paris, France},
year={2018},
author={Nevein Ibrahim and Niti Aggarwal and Steve Y Cho and Christopher J Francois},
abstract={Early recognition of cardiac sarcoidosis (CS) is important to initiate early treatment and prevent heart failure and sudden cardiac death. However, diagnosis of CS can be challenging and requires a high-index of suspicion. Cardiac magnetic resonance imaging (CMR) and 18F-fluorodeoxyglucose PET (18F FDG PET) have opened new avenues in the detection of CS. Experience with hybrid PET/MRI at our institution demonstrates improved workflow, decreased patient radiation exposure (compared to PET/CT) and incremental diagnostic value in imaging of CS. Both modalities are complementary and offer important diagnostic and prognostic clinical data.}
}